A novel one-dimensional zinc coordination polymer containing 4-methylbenzoate and 4,4-bipyridine
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The title compound, catena-poly[[tris(μ-4-methylbenzoato)-κ2O:O;κ4O:O′-(4-methylbenzoato-κ2O,O′)dizinc(II)]-μ-4,4′-bipyridine-κ2N:N′], [Zn2(C8H7O2)4(C10H8N2)]n, is a novel coordination polymer. The asymmetric unit contains two unique ZnII ions, four 4-methylbenzoate ligands and one 4,4′-bipyridine (4,4′-bpy) ligand, all in general positions. The four 4-methylbenzoate ligands link the two ZnII centres to form a dinuclear unit, with a Zn...Zn separation of 3.188 (2) Å, which can be regarded as a supramolecular secondary building unit (SBU). These SBUs are further bridged by 4,4′-bpy ligands, forming ...
Source: Acta Crystallographica Section C - July 4, 2008 Category: Chemistry Authors: Ma, D.-Y.Deng, G.-H. Tags: metal-organic compounds Source Type: journals
Superlattice nanowire pattern transfer (snap)
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James R. HeathWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/ar800015y (Source: Accounts of Chemical Research)
Source: Accounts of Chemical Research - July 4, 2008 Category: Chemistry Source Type: journals
Resolution of cross-type optical particle separation
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Sang Bok Kim, Sang Youl Yoon, Hyung Jin Sung, and Sang Soo KimWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/ac800740b (Source: Analytical Chemistry)
Source: Analytical Chemistry - July 4, 2008 Category: Chemistry Source Type: journals
Totally selective synthesis of enantiopure (3s,5s)- and (3r,5r)-4-amino-3,5-dihydroxypiperidines from aminodiepoxides derived from serine
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José M. Concellón, Ignacio A. Rivero, Humberto Rodríguez-Solla, Carmen Concellón, Estibaly España, Santiago García-Granda, and M. R. DíazWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Note) DOI: 10.1021/jo801058c (Source: The Journal of Organic Chemistry)
Source: The Journal of Organic Chemistry - July 4, 2008 Category: Chemistry Source Type: journals
Accelerating density functional calculations with graphics processing unit
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Koji YasudaWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/ct8001046 (Source: Journal of Chemical Theory and Computation)
Source: Journal of Chemical Theory and Computation - July 4, 2008 Category: Chemistry Source Type: journals
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery
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Tracey Pirali, Francesca Pagliai, Ciro Mercurio, Roberto Boggio, Pier Luigi Canonico, Giovanni Sorba, Gian Cesare Tron, and Armando A. GenazzaniWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Report) DOI: 10.1021/cc800061c (Source: Journal of Combinatorial Chemistry)
Source: Journal of Combinatorial Chemistry - July 4, 2008 Category: Chemistry Source Type: journals
Molecular docking of cathepsin l inhibitors in the binding site of papain
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Mary Pat Beavers, Michael C. Myers, Parag P. Shah, Jeremy E. Purvis, Scott L. Diamond, Barry S. Cooperman, Donna M. Huryn, and Amos B. Smith IIIWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/ci800085c (Source: Journal of Chemical Information and Modeling)
Source: Journal of Chemical Information and Modeling - July 4, 2008 Category: Chemistry Source Type: journals
Molecular data protection
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Scientists in India have found the key to protecting information at a molecular level (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - July 4, 2008 Category: Chemistry Source Type: journals
Interview: navy's sensing mission
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Frances Ligler tells Kathleen Too about portable, automated biosensors for fast, on-site detection of pathogens, toxins, pollutants, drugs and explosives (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - July 4, 2008 Category: Chemistry Source Type: journals
Tubular cells
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A new method for growing cylinders of living cells could be used for tissue engineering (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - July 4, 2008 Category: Chemistry Source Type: journals
Interview: model membranes
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Patricia Bassereau tells Michael Brown about the importance of the membrane in cellular functions (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - July 4, 2008 Category: Chemistry Source Type: journals
Borane leads the way to alternative fuels
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New routes to hydrogen storage materials have been developed by scientists in the US and Singapore (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - July 4, 2008 Category: Chemistry Source Type: journals
Futuregen re-launched amidst congressional enquiry
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US lawmakers probe DOE decisions on flagship clean coal programme (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - July 4, 2008 Category: Chemistry Source Type: journals
Atomic scale microscopy goes commercial
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Instrument manufacturers bring state-of-the-art transmission electron microscopes to the market (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - July 4, 2008 Category: Chemistry Source Type: journals
Colorimetric discrimination between important alkaloid nuclei mediated by a bis-salphen chromophore
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Sander J. Wezenberg, Eduardo C. Escudero-Adán, Jordi Benet-Buchholz, and Arjan W. KleijWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801167r (Source: Organic Letters)
Source: Organic Letters - July 4, 2008 Category: Chemistry Source Type: journals
2-nitroglycals as powerful glycosyl donors: application in the synthesis of biologically important molecules
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Richard R. Schmidt and Yashwant D. VankarWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/ar7002495 (Source: Accounts of Chemical Research)
Source: Accounts of Chemical Research - July 4, 2008 Category: Chemistry Source Type: journals
An alternative method for the evaluation of docking performance: rsr vs rmsd
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Dilmurat Yusuf, Andrew M. Davis, Gerard J. Kleywegt, and Stefan SchmittWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/ci800084x (Source: Journal of Chemical Information and Modeling)
Source: Journal of Chemical Information and Modeling - July 4, 2008 Category: Chemistry Source Type: journals
Reactive extraction of enantiomers of 1,2-amino alcohols via stereoselective thermodynamic and kinetic processes
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Lijun Tang, Sujung Choi, Raju Nandhakumar, Hyunjung Park, Hyein Chung, Jik Chin, and Kwan Mook KimWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Note) DOI: 10.1021/jo800670t (Source: The Journal of Organic Chemistry)
Source: The Journal of Organic Chemistry - July 4, 2008 Category: Chemistry Source Type: journals
Synthetic studies on ezomycins: stereoselective route to a thymine octosyl nucleoside derivative
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Juhienah K. Khalaf, David G. VanderVelde, and Apurba DattaWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jo801050r (Source: The Journal of Organic Chemistry)
Source: The Journal of Organic Chemistry - July 4, 2008 Category: Chemistry Source Type: journals
A highly efficient solvent-free asymmetric direct aldol reaction organocatalyzed by recoverable (s)-binam-l-prolinamides. esi-ms evidence of the enamine−iminium formation
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Gabriela Guillena, Maria del Carmen Hita, Carmen Nájera, and Santiago F. ViózquezWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jo800773q (Source: The Journal of Organic Chemistry)
Source: The Journal of Organic Chemistry - July 4, 2008 Category: Chemistry Source Type: journals
Rapid and efficient pd-catalyzed sonogashira coupling of aryl chlorides
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He Huang, Hong Liu, Hualiang Jiang, and Kaixian ChenWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Note) DOI: 10.1021/jo800994f (Source: The Journal of Organic Chemistry)
Source: The Journal of Organic Chemistry - July 4, 2008 Category: Chemistry Source Type: journals
Combinatorial and automated synthesis of phosphodiester galactosyl cluster on solid support by click chemistry assisted by microwaves
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Gwladys Pourceau, Albert Meyer, Jean-Jacques Vasseur, and François MorvanWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Note) DOI: 10.1021/jo8009837 (Source: The Journal of Organic Chemistry)
Source: The Journal of Organic Chemistry - July 4, 2008 Category: Chemistry Source Type: journals
Preparation, characterization, and electrochemical properties of a new series of hybrid dendrimers containing a viologen core and fréchet and newkome dendrons
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Papri Bhattacharya and Angel E. KaiferWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Featured Article) DOI: 10.1021/jo800953v (Source: The Journal of Organic Chemistry)
Source: The Journal of Organic Chemistry - July 4, 2008 Category: Chemistry Source Type: journals
Synthesis of 3-selena-1-dethiacephems and selenazepines via iodocyclization
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Dinesh R. Garud and Mamoru KoketsuWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801010y (Source: Organic Letters)
Source: Organic Letters - July 4, 2008 Category: Chemistry Source Type: journals
A regio- and stereocontrolled approach to pyranosyl c-nucleoside synthesis
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Philip Redpath, Simon Macdonald, and Marie E. MigaudWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801183e (Source: Organic Letters)
Source: Organic Letters - July 4, 2008 Category: Chemistry Source Type: journals
Arylation of phe and tyr side chains of unprotected peptides by a suzuki−miyaura reaction in water
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Maria Vilaró, Gemma Arsequell, Gregorio Valencia, Alfredo Ballesteros, and José BarluengaWeb Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801009z (Source: Organic Letters)
Source: Organic Letters - July 4, 2008 Category: Chemistry Source Type: journals
Optically active chiral ligands,
ferrocenyloxazolinylphosphines (foxaps): development and application
to catalytic asymmetric reactions
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SynlettDOI: 10.1055/s-2008-1077903AbstractThe development of optically active chiral ligands, ferrocenyloxazolinylphosphines
(FOXAPs), and their application to catalytic asymmetric reactions
are reviewed. FOXAPs have been prepared in high yields from the
corresponding chiral oxazolinylferrocenes via diastereoselective
lithiation followed by quenching with chlorodiphenylphosphine. They
work quite effectively as chiral ligands for a variety of transition-metal-catalyzed
asymmetric reactions such as hydrosilylation and transfer hydrogenation
of ketones and imines, kinetic resolution of alcohols, carbon-carbon
bond-forming rea...
Source: Synlett - July 3, 2008 Category: Chemistry Tags: account Source Type: journals
Compact bulbs made safer
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Selenium sorbent lowers risk of mercury exposure from light bulbs (Source: Chemical)
Source: Chemical - July 3, 2008 Category: Chemistry Source Type: journals
Sodium iodine(v) oxyfluoride, naio2f2
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As an extension of a general structural study concerning fluorides and oxyfluorides of cations presenting a stereochemically active electronic lone pair, until now limited to tellurium(IV) phases, the previously unknown structure of NaIO2F2 corresponds to a new structure type based on isolated IO2F2− polyhedra forming sheets separated by Na+ layers. The sodium ion is octahedrally coordinated with 2/m site symmetry, while the IV atom has m2m symmetry with a stereochemically active lone electron pair. The O and F atoms (both with m symmetry) are bonded to the IV atoms in a fully ordered manner. A comparison with the struct...
Source: Acta Crystallographica Section C - July 3, 2008 Category: Chemistry Authors: Laval, J.-P.Jennene Boukharrata, N. Tags: inorganic compounds Source Type: journals
Gamma-secretase: structure, function, and modulation for alzheimer's disease.
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Gamma-secretase: structure, function, and modulation for Alzheimer's disease.
Curr Top Med Chem. 2008;8(1):2-8
Authors: Wolfe MS
Gamma-secretase proteolyzes a variety of membrane-associated fragments derived from type I integral membrane proteins, including the amyloid beta-protein precursor, involved in Alzheimer's disease, and the Notch receptor, critical for cellular differentiation. This protease is composed of four integral membrane proteins: presenilin, nicastrin, Aph-1 and Pen-2. Assembly of these four components leads to presenilin autoproteolysis into two subunits, each of which contributes one asparta...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Wolfe MS Tags: Curr Top Med Chem Source Type: journals
Activity of gamma-secretase on substrates other than app.
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Activity of gamma-secretase on substrates other than APP.
Curr Top Med Chem. 2008;8(1):9-16
Authors: Lleó A
Gamma-secretase is an intramembranous protein complex that cleaves many type-I membrane proteins, including the Notch receptor and the beta-amyloid precursor protein (APP). Interest in gamma-secretase comes, in part, from the fact that this multiprotein complex is responsible for the cleavage of APP that generates the amyloid-beta peptide (Abeta), one of the primary components of amyloid plaques in Alzheimer's disease (AD). Over the last years, molecular identification of the complex has shown that g...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Lleó A Tags: Curr Top Med Chem Source Type: journals
Recent progress in the medicinal chemistry of gamma-secretase inhibitors.
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Abeta is implicated in the initiation and progression of Alzheimer's disease (AD) by the phenotypic analysis of mutations in three human genes that lead to inherited, early forms of AD and data from preclinical studies. Based on this evidence, gamma-secretase inhibitors are being actively pursued as potential AD therapeutics to reduce Abeta formation. This manuscript reviews recent progress in the medicinal chemistry of three major classes of gamma-secretase inhibitors: peptide isosteres, azepines, and sulfonamides. Peptide isosteres have been useful for demonstrating that presenilin is the catalytic subunit of gamma-s...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Olson RE, Albright CF Tags: Curr Top Med Chem Source Type: journals
Gamma-secretase modulation and its promise for alzheimer's disease: a rationale for drug discovery.
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Gamma-secretase modulation and its promise for Alzheimer's disease: a rationale for drug discovery.
Curr Top Med Chem. 2008;8(1):34-7
Authors: Beher D
The genetics of Alzheimer's disease (AD) implies that restoring non-pathological levels or ratios of different amyloid-beta (Abeta) peptide species in the brain could prevent the onset or delay the progression of this neurodegenerative disease. In particular, a selective reduction of the longer Abeta(1-42) peptide which is widely believed to be causative of AD is currently seen as an attractive approach for a disease-modifying therapy. Based on the knowledge that...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Beher D Tags: Curr Top Med Chem Source Type: journals
Gamma-secretase modulation and its promise for alzheimer's disease: a medicinal chemistry perspective.
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Gamma-secretase modulation and its promise for Alzheimer's disease: a medicinal chemistry perspective.
Curr Top Med Chem. 2008;8(1):38-46
Authors: Peretto I, La Porta E
Gamma-secretase modulation holds the promise for the development of a disease-modifying therapy for Alzheimer's disease (AD). This novel concept of manipulating the cleavage specificity of the gamma secretase enzyme by pharmacological means implies that steady state levels of the potentially disease-causing amyloid-beta(1-42) peptide can be lowered without the undesired side effects associated with full inhibition of this aspartyl-type protease....
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Peretto I, La Porta E Tags: Curr Top Med Chem Source Type: journals
Possible mechanisms of action of nsaids and related compounds that modulate gamma-secretase cleavage.
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Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage.
Curr Top Med Chem. 2008;8(1):47-53
Authors: Kukar T, Golde TE
Genetic and biochemical evidence continues to implicate the production and accumulation of the Abeta42 peptide as the causative factor in Alzheimer's disease (AD). Thus, a variety of strategies have been developed to decrease the production and/or aggregation of this peptide, which may be clinically useful for the treatment of this devastating disorder. Recently, the discovery that some non-steroidal anti-inflammatory drugs (NSAIDs) appear to selecti...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Kukar T, Golde TE Tags: Curr Top Med Chem Source Type: journals
Therapeutic potential of gamma-secretase inhibitors and modulators.
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According to the beta-amyloid (Abeta) hypothesis, compounds that inhibit gamma-secretase, the pivotal enzyme that generates Abeta, are potential therapeutics for Alzheimer's disease (AD). Studies in both transgenic and non-transgenic animal models of AD have indicated that gamma-secretase inhibitors, administered by the oral route, are able to lower brain Abeta concentrations. However, scanty data are available on the effects of these compounds on brain Abeta deposition after prolonged administration. Behavioral studies are also scarce with only one study indicating positive cognitive effects of a peptidomimetic compou...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Imbimbo BP Tags: Curr Top Med Chem Source Type: journals
Molecule of the month. overcoming resistance.
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Molecule of the month. Overcoming resistance.
Curr Top Med Chem. 2008;8(1):62
Authors: Thomas AL, Lindsley CW
PMID: 18229423 [PubMed - indexed for MEDLINE] (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Thomas AL, Lindsley CW Tags: Curr Top Med Chem Source Type: journals
New directions in the chemistry and biology of carbohydrates.
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PMID: 18289077 [PubMed - indexed for MEDLINE] (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Giuliano RM Tags: Curr Top Med Chem Source Type: journals
Synthetic tlr4-active glycolipids as vaccine adjuvants and stand-alone immunotherapeutics.
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Synthetic TLR4-active glycolipids as vaccine adjuvants and stand-alone immunotherapeutics.
Curr Top Med Chem. 2008;8(2):64-79
Authors: Johnson DA
The design of vaccine adjuvants and stand-alone immunotherapeutics has historically been a mix of alchemy and accident partly because of the complex nature of the molecular mechanisms involved in immune system function. The recent discovery of pattern recognition receptors and toll-like receptors (TLRs) in particular on cells of the immune system has shown the important role that stimulation of these cell receptors by microbial products plays in both innate and adapti...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Johnson DA Tags: Curr Top Med Chem Source Type: journals
Immobilization of heparin: approaches and applications.
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Heparin, an anticoagulant, has been used in many forms to treat various diseases. These forms include soluble heparin and heparin immobilized to supporting matrices by physical adsorption, by covalent chemical methods and by photochemical attachment. These immobilization methods often require the use of spacers or linkers. This review examines and compares various techniques that have been used for the immobilization of heparin as well as applications of these immobilized heparins. In the applications reviewed, immobilized heparin is compared with soluble heparin for efficient and versatile use in each of the various a...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Murugesan S, Xie J, Linhardt RJ Tags: Curr Top Med Chem Source Type: journals
Pyranose n-glycosyl amines: emerging targets with diverse biological potential.
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Pyranose N-glycosyl amines: emerging targets with diverse biological potential.
Curr Top Med Chem. 2008;8(2):101-13
Authors: Norris P
Interest in the chemistry and biological properties of non-nucleoside N-glycosidic compounds has gathered pace over the past several years; the occurrence of the N-glycoside moiety in glycoproteins and a range of active natural products has prompted the synthesis of a diverse spectrum of related materials with promising potential in medicinal chemistry. Particularly prominent has been the synthesis of novel N-glycosyl amides, 1,2,3-triazoles, and progress in the construction and ...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Norris P Tags: Curr Top Med Chem Source Type: journals
The de novo synthesis of oligosaccharides: application to the medicinal chemistry sar-study of digitoxin.
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The de novo synthesis of oligosaccharides: application to the medicinal chemistry SAR-study of digitoxin.
Curr Top Med Chem. 2008;8(2):114-25
Authors: Zhou M, O'Doherty G
To address the medicinal chemist's need for new synthetic methods for the preparation of unnatural carbohydrates, a new de novo method for carbohydrate synthesis has been developed. These routes use a palladium catalyzed glycosylation reaction to stereoselectively control the anomeric center and subsequent diastereoselective post glycosylation to install the remaining sugar stereocenters. The utility of this method was demonstrated by the synt...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Zhou M, O'Doherty G Tags: Curr Top Med Chem Source Type: journals
Recent developments in synthetic oligosaccharide-based bacterial vaccines.
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Synthetic advances made possible chemical assembly of complex oligosaccharide fragments of polysaccharide domains on the surface of human pathogenic bacteria. These oligosaccharides may be recognized by antibodies raised against high molecular weight, native, polysaccharides. In addition to their antigenicity, synthetic oligosaccharides can also function as haptens in their protein conjugates that can elicit not only oligo- but also polysaccharide-specific IgG antibodies in animal models and in humans. A major milestone in the development of new generation vaccines was the demonstration that protein conjugates of synth...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Pozsgay V Tags: Curr Top Med Chem Source Type: journals
Current understanding on biosynthesis of microbial polysaccharides.
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The surfaces of almost all microbes are decorated with remarkable variations of polysaccharides such as O-antigen, capsular polysaccharides (CPS), and exopolysaccharides (EPS) in bacteria, lipoarabinomannans (LAM) in mycobacteria and lipophosphoglycan (LPG) in Leishmania. These polysaccharides play important roles in many biological processes, and they can function as the virulence determinants in the pathogens. The basic structures of these polysaccharides are known, but they show species-specificity or stage-specificity. For example, there are 186 O-serotypes and 80 capsular serotypes in E. coli. Despite the variatio...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Guo H, Yi W, Song JK, Wang PG Tags: Curr Top Med Chem Source Type: journals
High-energy glycoconjugates: synthetic transformations of carbohydrates using microwave and ultrasonic energy.
discuss this article
Methods to transform carbohydrates are often complex and tedious, both due to the vast array of naturally occurring and synthetically designed scaffolds which may manifest meager to drastic reactivity, dependent upon the transformation sought and the stereogenic site chosen. In order to facilitate and expedite desired synthetic transformation, many researchers are utililizing microwave and ultrasonic irradiation to achieve their goals, in generally high yields within a shorter period of time, and often without undesirous byproducts. The basic physical principles underlying the energy regimes are qualitatively discussed...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Cioffi EA Tags: Curr Top Med Chem Source Type: journals
Carbohydrate-based drugs in the treatment of epilepsy, depression and other affective disorders.
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Mental illness affects a quarter of the US population. Recently, it has been shown that new, carbohydrate-based drugs hold promise in the treatment of central nervous system (CNS) disorders. A variety of ways in which drugs of this sort may reduce the symptoms of epilepsy, depression and other affective disorders have been proposed, including: targeting the immune system, disrupting glycolysis, acting at different sites in the hypothalamic-pituitary-adrenal (HPA) axis, and targeting specific biochemical pathways such as the inositol pathway. In the present review, the structure-activity relationships (SARs) of a wide v...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Talisman IJ, Marzabadi CH Tags: Curr Top Med Chem Source Type: journals
Cb receptor ligands from plants.
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CB receptor ligands from plants.
Curr Top Med Chem. 2008;8(3):173-86
Authors: Woelkart K, Salo-Ahen OM, Bauer R
Advances in understanding the physiology and pharmacology of the endogenous cannabinoid system have potentiated the interest of cannabinoid receptors as potential therapeutic targets. Cannabinoids have been shown to modulate a variety of immune cell functions and have therapeutic implications on central nervous system (CNS) inflammation, chronic inflammatory conditions such as arthritis, and may be therapeutically useful in treating autoimmune conditions such as multiple sclerosis. Many of these drug ...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Woelkart K, Salo-Ahen OM, Bauer R Tags: Curr Top Med Chem Source Type: journals
Recent advances in the development of selective ligands for the cannabinoid cb(2) receptor.
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Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor.
Curr Top Med Chem. 2008;8(3):187-204
Authors: Marriott KS, Huffman JW
Two subtypes of the mammalian cannabinoid receptor have been identified and successfully cloned since 1990. The CB(1) receptor is primarily located in the central nervous system and the CB(2) receptor is almost exclusively expressed in cells of the immune system. The CB(1) and CB(2) receptors are both G-protein coupled receptors and are involved in the inhibition of adenylate cyclase. The CB(2) receptor is of particular importance due to its involvemen...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Marriott KS, Huffman JW Tags: Curr Top Med Chem Source Type: journals
Cb1 cannabinoid antagonists: structure-activity relationships and potential therapeutic applications.
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CB1 cannabinoid antagonists: structure-activity relationships and potential therapeutic applications.
Curr Top Med Chem. 2008;8(3):205-30
Authors: Jagerovic N, Fernandez-Fernandez C, Goya P
During the last decade there has been a growing interest towards the modulation of the cannabinoid CB1 receptor. The identification of CB1 cannabinoid receptor antagonists has been one of the major advances in cannabinoid research. Thus, the development of these ligands has opened new therapeutic applications. Since the discovery of the first cannabinoid receptor antagonist, rimonabant, by Sanofi in 1994, a large number of s...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Jagerovic N, Fernandez-Fernandez C, Goya P Tags: Curr Top Med Chem Source Type: journals
The medicinal chemistry of agents targeting monoacylglycerol lipase.
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Monoacylglycerol lipase (MAGL) has been recently proposed as the main enzymatic activity responsible for the in vivo hydrolysis of the most abundant endocannabinoid in the brain, the 2-arachidonoylglycerol (2-AG). The endocannabinoids, mainly anandamide (AEA) and 2-AG, are a class of lipid messengers that modulate a broad number of physiological processes both in the central nervous system and in the periphery. To date, AEA has been by far the most studied endocannabinoid, although increasing evidence is pointing out the prominent, and sometimes underestimated, role of 2-AG in the regulation of different functions. The...
Source: Current Topics in Medicinal Chemistry - July 3, 2008 Category: Chemistry Authors: Viso A, Cisneros JA, Ortega-Gutiérrez S Tags: Curr Top Med Chem Source Type: journals
