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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Intermolecular C-O Addition of Carboxylic Acids to Arynes: Synthesis of o-Hydroxyaryl Ketones, Xanthones, 4-Chromanones, and Flavones.
Abstract An efficient and simple route to biologically and pharmaceutically important o-hydroxyaryl ketones, xanthones, 4-chromanones, and flavones has been developed utilizing readily available carboxylic acids and commercially available o-(trimethylsilyl)aryl triflates. PMID: 23520410 [PubMed - as supplied by publisher] (Source: Tetrahedron)
Source: Tetrahedron - April 1, 2013 Category: Chemistry Authors: Dubrovskiy AV, Larock RC Tags: Tetrahedron Source Type: research

Fpr2 and CCR2 Control DC Trafficking in Asthmatic Lung [Molecular Bases of Disease]
We report that in allergic airway inflammation, CCR2 mediated the recruitment of monocyte-derived DCs to the perivascular region, and Fpr2 was required for further migration of the cells into the bronchiolar area. We additionally found that the bronchoalveolar lavage liquid from mice with airway inflammation contained both the CCR2 ligand CCL2 and an Fpr2 agonist CRAMP. Furthermore, similar to Fpr2−/− mice, in the inflamed airway of CRAMP−/− mice, DC trafficking into the peribronchiolar areas was diminished. Our study demonstrates that the interaction of CCR2 and Fpr2 with their endogenous ligands sequentially medi...
Source: Journal of Biological Chemistry - June 7, 2013 Category: Chemistry Authors: Chen, K., Liu, M., Liu, Y., Wang, C., Yoshimura, T., Gong, W., Le, Y., Tessarollo, L., Wang, J. M. Tags: Immunology Source Type: research

Total synthesis of (-)-dihydroprotolichesterenic acid via diastereoselective conjugate addition to chiral fumarates.
Abstract A diastereoselective conjugate addition of a variety of monoorganocuprates, Li[RCuI], to chiral fumarates to provide funtionalized succinates has been developed. The utility of this reaction is demonstrated in a concise total synthesis of (-)-dihydroprotolichesterenic acid that required only four steps and proceeded in an overall 31% yield. PMID: 23539490 [PubMed - as supplied by publisher] (Source: Tetrahedron Letters)
Source: Tetrahedron Letters - April 17, 2013 Category: Chemistry Authors: Hethcox JC, Shanahan CS, Martin SF Tags: Tetrahedron Lett Source Type: research

Disposable amperometric magnetoimmunosensor for the sensitive detection of the cardiac biomarker amino-terminal pro-B-type natriuretic peptide in human serum.
Abstract A novel amperometric magnetoimmunosensor using an indirect competitive format is developed for the sensitive detection of the amino-terminal pro-B-type natriuretic peptide (NT-proBNP). The immunosensor design involves the covalent immobilization of the antigen onto carboxylic-modified magnetic beads (HOOC-MBs) activated with N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide (EDC) and N-hydroxysulfosuccinimide (sulfo-NHS), and further incubation in a mixture solution containing variable concentrations of the antigen and a fixed concentration of an HRP-labeled detection antibody. Accordingly, the target NT-proB...
Source: Analytica Chimica Acta - June 15, 2013 Category: Chemistry Authors: Esteban-Fernández de Ávila B, Escamilla-Gómez V, Campuzano S, Pedrero M, Pingarrón JM Tags: Anal Chim Acta Source Type: research

Mitochondrial Damage in Pemphigus [Immunology]
In this study, we sought to identify changes in the vital mitochondrial functions in KCs treated with the sera from PV patients and healthy donors. PV sera significantly increased proton leakage from KCs, suggesting that PV IgGs increase production of reactive oxygen species. Indeed, measurement of intracellular reactive oxygen species production showed a drastic increase of cell staining in response to treatment by PV sera, which was confirmed by FACS analysis. Exposure of KCs to PV sera also caused dramatic changes in the mitochondrial membrane potential detected with the JC-1 dye. These changes can trigger the mitochond...
Source: Journal of Biological Chemistry - June 7, 2013 Category: Chemistry Authors: Kalantari-Dehaghi, M., Chen, Y., Deng, W., Chernyavsky, A., Marchenko, S., Wang, P. H., Grando, S. A. Tags: Molecular Bases of Disease Source Type: research

Monomeric Fc Modality Engineered by N-Glycosylation [Immunology]
Human IgG is a bivalent molecule that has two identical Fab domains connected by a dimeric Fc domain. For therapeutic purposes, however, the bivalency of IgG and Fc fusion proteins could cause undesired properties. We therefore engineered the conversion of the natural dimeric Fc domain to a highly soluble monomer by introducing two Asn-linked glycans onto the hydrophobic CH3-CH3 dimer interface. The monomeric Fc (monoFc) maintained the binding affinity for neonatal Fc receptor (FcRn) in a pH-dependent manner. We solved the crystal structure of monoFc, which explains how the carbohydrates can stabilize the protein surface a...
Source: Journal of Biological Chemistry - June 7, 2013 Category: Chemistry Authors: Ishino, T., Wang, M., Mosyak, L., Tam, A., Duan, W., Svenson, K., Joyce, A., O'Hara, D. M., Lin, L., Somers, W. S., Kriz, R. Tags: Protein Structure and Folding Source Type: research

Spiroaminal Model Systems of the Marineosins with Final Step Pyrrole Incorporation.
Abstract In this Letter, we describe a short, 6-step enantioselective route to spiroaminal lactam model systems reminiscent of marineosins A and B has been developed starting from either (R)- or (S)-hydroxysuccinic acid, respectively, in ~9% overall yield. This route enables late stage incorporation of the pyrrole ring at C5 via nucleophilic displacement of an iminium triflate salt. PMID: 23606772 [PubMed - as supplied by publisher] (Source: Tetrahedron Letters)
Source: Tetrahedron Letters - May 1, 2013 Category: Chemistry Authors: Panarese JD, Konkol LC, Berry CB, Bates BS, Aldrich LN, Lindsley CW Tags: Tetrahedron Lett Source Type: research

Method performance study of on-line internal standard addition in inductively coupled plasma mass spectrometry
Andras Torvenyi, Kunchit Judprasong, Ales Fajgelj (Paper from Journal of Analytical Atomic Spectrometry, 2007, 22) DOI: 10.1039/b704867j (Source: RSC - J. Anal. At. Spectrom. latest articles)
Source: RSC - J. Anal. At. Spectrom. latest articles - September 12, 2007 Category: Chemistry Authors: Andras Torvenyi Kunchit Judprasong Ales Fajgelj Source Type: research

Regulation of Glucan Metabolism [Microbiology]
GlgE is a maltosyltransferase involved in the biosynthesis of α-glucans that has been genetically validated as a potential therapeutic target against Mycobacterium tuberculosis. Despite also making α-glucan, the GlgC/GlgA glycogen pathway is distinct and allosterically regulated. We have used a combination of genetics and biochemistry to establish how the GlgE pathway is regulated. M. tuberculosis GlgE was phosphorylated specifically by the Ser/Thr protein kinase PknB in vitro on one serine and six threonine residues. Furthermore, GlgE was phosphorylated in vivo when expressed in Mycobacterium bovis bacillus Calmette–G...
Source: Journal of Biological Chemistry - June 7, 2013 Category: Chemistry Authors: Leiba, J., Syson, K., Baronian, G., Zanella–Cleon, I., Kalscheuer, R., Kremer, L., Bornemann, S., Molle, V. Tags: Microbiology Source Type: research

Effect of CeO2 Addition to Al2 O3 Supports for Pt Catalysts on the Aqueous-Phase Reforming of Glycerol.
Abstract A series of Pt catalysts supported on Al2 O3 that was doped with different amounts of CeO2 was developed, characterized, and tested in the aqueous-phase reforming (APR) of glycerol to H2 . Catalyst 3Pt/3CeAl, which bore 3 wt % Pt on a support that contained 3 wt % CeO2 , showed the highest carbon conversion to gas (85 %) and the highest H2 yield (80 %) for a feedstock of 1 wt % glycerol in water at 240 °C and 40 bar. A CeO2 /Al2 O3 support with only 1 wt % Pt also showed high H2 selectivity and carbon conversion to gas, as well as a much lower CH4 yield than the benchmark 3Pt/Al ca...
Source: ChemSusChem - April 24, 2013 Category: Chemistry Authors: Rahman MM, Church TL, Minett AI, Harris AT Tags: ChemSusChem Source Type: research

Adduct supported analysis of γ-hydroxybutyrate in human serum with LC-MS/MS.
Abstract To avoid the detection of small fragmentation products of γ-hydroxybutyrate (GHB), a liquid chromatography-tandem mass spectrometry GHB quantification method in human serum supported by adduct formation was developed and validated. The continuous infusion of GHB/GHB-D6 made the identification of two adducts possible and GHB/GHB-D6 sodium acetate adduct fragmentation was used as target mass transition. A Luna 5 μm C18 (2) 100 A, 150 mm × 2 mm analytical column and elution with a programmed flow of the mobile phase consisting of 10 % A (H2O/methanol = 95/5, v/v) and 90 % B (H2O/methanol = 3/97, ...
Source: Analytical and Bioanalytical Chemistry - May 29, 2013 Category: Chemistry Authors: Dziadosz M, Weller JP, Klintschar M, Teske J Tags: Anal Bioanal Chem Source Type: research

Exploiting Historical Databases to Design the Target Quality Profile for a New Product
Industrial & Engineering Chemistry ResearchDOI: 10.1021/ie3032839 (Source: Industrial and Engineering Chemical Research)
Source: Industrial and Engineering Chemical Research - June 10, 2013 Category: Chemistry Authors: Emanuele Tomba, Pierantonio Facco, Fabrizio Bezzo and Salvador García-Muñoz Source Type: research

Detection of mRNA of the Cyclin D1 Breast Cancer Marker by a Novel Duplex-DNA Probe
Journal of Medicinal ChemistryDOI: 10.1021/jm301838y (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 6, 2013 Category: Chemistry Authors: Meirav Segal, Eylon Yavin, Pinhas Kafri, Yaron Shav-Tal and Bilha Fischer Source Type: research

New Material For Energy-Efficient Refrigeration
Materials Science: A class of inexpensive transition-metal boride compounds could cool refrigerators via applied magnetic fields (Source: Chemical and Engineering News)
Source: Chemical and Engineering News - June 12, 2013 Category: Chemistry Authors: Katherine Bourzac Source Type: research

Systematic Structure Modifications of Multitarget Prostate Cancer Drug Candidate Galeterone To Produce Novel Androgen Receptor Down-Regulating Agents as an Approach to Treatment of Advanced Prostate Cancer
Journal of Medicinal ChemistryDOI: 10.1021/jm400048v (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - June 7, 2013 Category: Chemistry Authors: Puranik Purushottamachar, Abhijit M. Godbole, Lalji K. Gediya, Marlena S. Martin, Tadas S. Vasaitis, Andrew K. Kwegyir-Afful, Senthilmurugan Ramalingam, Zeynep Ates-Alagoz and Vincent C. O. Njar Source Type: research

Effect of ultrasound on different quality parameters of apple juice.
Abstract Fresh apple juice treated with ultrasound (for 0, 30, 60 and 90min, at 20°C, 25kHz frequency) was evaluated for different physico-chemical, Hunter color values, cloud value, antioxidant capacity, scavenging activity on 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, ascorbic acid, total phenolics, flavonoids, flavonols and microbial characteristics. No significant effect of sonication was observed on pH, total soluble solids (°Brix) and titratable acidity of apple juice. Sonication significantly improved ascorbic acid, cloud value, phenolic compounds, antioxidant capacity, DPPH free radical scavenging...
Source: Ultrasonics Sonochemistry - May 22, 2013 Category: Chemistry Authors: Abid M, Jabbar S, Wu T, Hashim MM, Hu B, Lei S, Zhang X, Zeng X Tags: Ultrason Sonochem Source Type: research

Attacking Drug-resistant Strains of Candida albicans♦ [Papers of the Week]
♦ See referenced article, J. Biol. Chem. 2013, 288, 16775–16787 Drug-resistant strains of the fungus Candida albicans have been on the rise for several decades, striking immunocompromised patients who have undergone organ transplants, chemotherapy, or HIV treatments. The drug-resistant fungus exploits a number of membrane-embedded transporters to eject drugs from its cells. The efflux pump Cdr1p is a member of the ATP-binding cassette (ABC) superfamily of transporters and is one of the main ways C. albicans rejects azole antifungal agents. In this Paper of the Week, a team led by Rajendra Prasad at the Jawaharlal Nehru...
Source: Journal of Biological Chemistry - June 7, 2013 Category: Chemistry Tags: Membrane Biology Source Type: research

IRG1 Feedback Promotes Endotoxin Tolerance [Immunology]
Sepsis-associated immunosuppression (SAIS) is regarded as one of main causes for the death of septic patients at the late stage because of the decreased innate immunity with a more opportunistic infection. LPS-tolerized macrophages, which are re-challenged by LPS after prior exposure to LPS, are regarded as the common model of hypo-responsiveness for SAIS. However, the molecular mechanisms of endotoxin tolerance and SAIS remain to be fully elucidated. In addition, negative regulation of the Toll-like receptor (TLR)-triggered innate inflammatory response needs further investigation. Here we show that expression of immune re...
Source: Journal of Biological Chemistry - June 7, 2013 Category: Chemistry Authors: Li, Y., Zhang, P., Wang, C., Han, C., Meng, J., Liu, X., Xu, S., Li, N., Wang, Q., Shi, X., Cao, X. Tags: Immunology Source Type: research

A New Quantitative Method for Gunshot Residue Analysis by Ion Beam Analysis
Analyst, 2013, Accepted ManuscriptDOI: 10.1039/C3AN00597F, PaperMatthew Christopher, John Warmenhoven, Francesco S Romolo, Matteo Donghi, Roger Webb, Chris Jeynes, N I Ward, Karen Kirkby, Melanie BaileyImaging and analyzing gunshot residue (GSR) particles using the scanning electron microscope equipped with an energy dispersive X-ray spectrometer (SEM-EDS) is a standard technique that can provide important forensic evidence,...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - June 8, 2013 Category: Chemistry Authors: Matthew Christopher Source Type: research

A General, Enantioselective Synthesis of 1-Azabicyclo[m.n.0]alkane Ring Systems.
Abstract In this Letter, we describe a novel approach for the general and enantioselective synthesis of a diverse array of small to large 1-azabicyclo[m.n.0]alkyl ring systems with an embedded olefin handle for further functionalization. The stereochemistry is established via a highly diastereoselective indium-mediated allylation of an Ellman sulfinimine in greater than 9:1 dr., which is readily separable by column chromatography to afford a single diastereomer. This methodology allows for the rapid preparation of 1-azabicyclo[m.n.0]alkane ring systems that are not readily accessible through any other chemistry in ...
Source: Tetrahedron Letters - March 27, 2013 Category: Chemistry Authors: Senter TJ, Schulte ML, Konkol LC, Wadzinski TE, Lindsley CW Tags: Tetrahedron Lett Source Type: research