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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Mechanism of Glycan Receptor Recognition and Specificity Switch for Avian, Swine, and Human Adapted Influenza Virus Hemagglutinins: A Molecular Dynamics PerspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of the American Chemical Society, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of the American Chemical Society)
Source: Journal of the American Chemical Society - November 5, 2009 Category: Chemistry Tags: article Source Type: journals

SIP30 Is Regulated by ERK in Peripheral Nerve Injury-induced Neuropathic Pain [Mechanisms Of Signal Transduction]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ERK plays an important role in chronic neuropathic pain. However, the underlying mechanism is largely unknown. Here we show that in chronic constriction injury-treated rat spinal cords, up-regulation of SIP30 (SNAP25-interacting protein 30), which is involved in the development and maintenance of chronic constriction injury-induced neuropathic pain, correlates with ERK activation and that the up-regulation of SIP30 is suppressed by intrathecal delivery of the MEK inhibitor U0126. In PC12 cells, up-regulation of SIP30 by nerve growth factor is also dependent on ERK activation. We found that there is an ERK-responsive region...
Source: Journal of Biological Chemistry - October 23, 2009 Category: Chemistry Authors: Peng, G., Han, M., Du, Y., Lin, A., Yu, L., Zhang, Y., Jing, N. Tags: Mechanisms Of Signal Transduction Source Type: journals

On the valences of bonds in the oxycomplexes of Sn2+Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The differences between Wang and Liebau's [Wang & Liebau (2007). Acta Cryst. B63, 216–228] stoichiometric valence (atomic valence) and structural valence (bond-valence sum) observed in Sn2+ and other lone-pair cation oxycomplexes arises from their use of the Brese & O'Keeffe bond-valence parameters which are based on the assumption that the bond-valence parameter b = 0.37 Å applies to all bond types. According to the theory of the bond-valence model, the bond-valence sum is necessarily equal to the ionic charge, implying that in the Wang and Liebau model the ionic charges are equal to the structural valence. If charge...
Source: Acta Crystallographica Section B - October 27, 2009 Category: Chemistry Authors: Brown, I.D. Tags: oxycomplexes atomic valence bond-valence sum research papers Source Type: journals

Single-molecule Analysis of Protein{middle dot}DNA Complexes Formed during Partition of Newly Replicated Plasmid Molecules in Streptococcus pyogenes [Dna: Replication, Repair, Recombination, and Chromosome Dynamics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Streptococcus pyogenes pSM19035 partition locus is ubiquitous among plasmids from vancomycin- or methicillin-resistant bacteria. An increasing understanding of this segregation system may highlight novel protein targets that could be blocked to curb bacterial proliferation. pSM19035 segregation depends on two homodimeric (2 (ParA) and 2 (ParB)) proteins and six cis-acting centromeric noncurved parS sites. In the presence of ATP·Mg2+, 2 (·ATP·Mg2+)2 binds DNA in a sequence-independent manner. Protein 2 binds with high affinity and cooperatively to B-form parS DNA. Atomic force microscopy experiments...
Source: Journal of Biological Chemistry - October 23, 2009 Category: Chemistry Authors: Pratto, F., Suzuki, Y., Takeyasu, K., Alonso, J. C. Tags: Dna: Replication, Repair, Recombination, and Chromosome Dynamics Source Type: journals

Differential pulse voltammetric simultaneous determination of noradrenalin and acetaminophen using a hematoxylin biosensor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A highly efficient noradrenalin (NA) biosensor was fabricated on the basis of hematoxylin electrodeposited on a glassy carbon electrode, GCE. The cyclic voltammetric responses of the hematoxylin biosensor at various scan rates, which were obtained in a 0.25mmolL(-1) NA solution, showed the characteristic shape typical of an EC(cat) process. The kinetic parameters such as electron transfer coefficient, alpha, the catalytic electron transfer rate constant, k', and the standard catalytic electron transfer rate constant, k(0), for oxidation of NA at the hematoxylin biosensor surface were estimated using cyclic and RDE volt...
Source: Talanta - October 21, 2009 Category: Chemistry Authors: Nasirizadeh N, Zare HR Tags: Talanta Source Type: journals

Three isomorphous 2,6-dibromopyridinium tetrabromidometallates: (C5H4Br2N)2[MBr4]·2H2O (M = Cu, Cd and Hg)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The structures of three isomorphous compounds, namely bis(2,6-dibromopyridinium) tetrabromidocuprate(II) dihydrate, (C5H4Br2N)2[CuBr4]·2H2O, bis(2,6-dibromopyridinium) tetrabromidocadmate(II) dihydrate, (C5H4Br2N)2[CdBr4]·2H2O, and bis(2,6-dibromopyridinium) tetrabromidomercurate(II) dihydrate, (C5H4Br2N)2[HgBr4]·2H2O, show a crystal supramolecularity represented by M—Br...H—O—H...Br—M intermolecular interactions along with (π)N—H...OH2 hydrogen-bonding interactions forming layers connected via aryl–aryl face-to-face stacking of cations, leading to a three-dimensional network. The anions have significantly ...
Source: Acta Crystallographica Section C - October 28, 2009 Category: Chemistry Authors: Al-Far, R.H.Haddad, S.F.Ali, B.F. Tags: metal-organic compounds Source Type: journals

A novel nonenzymatic hydrogen peroxide sensor based on multi-wall carbon nanotube/silver nanoparticle nanohybrids modified gold electrode.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel strategy to fabricate hydrogen peroxide (H(2)O(2)) sensor was developed based on multi-wall carbon nanotube/silver nanoparticle nanohybrids (MWCNT/Ag nanohybrids) modified gold electrode. The process to synthesize MWCNT/Ag nanohybrids was facile and efficient. In the presence of carboxyl groups functionalized multi-wall carbon nanotubes (MWCNTs), silver nanoparticles (Ag NPs) were in situ generated from AgNO(3) aqueous solution and readily attached to the MWCNTs convex surfaces at room temperature, without any additional reducing reagent or irradiation treatment. The formation of MWCNT/Ag nanohybrids product wa...
Source: Talanta - October 21, 2009 Category: Chemistry Authors: Zhao W, Wang H, Qin X, Wang X, Zhao Z, Miao Z, Chen L, Shan M, Fang Y, Chen Q Tags: Talanta Source Type: journals

Gold nanoparticles give super sensitive cancer testEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Technique uses gold nanoparticles and DNA in new test for prostate cancer 300 times more sensitive than commercial assays (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - October 21, 2009 Category: Chemistry Source Type: journals

VadimezanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tumor cells rely on the existence of a specialized vasculature for the oxygen and nutrients that they require in order to grow and survive. Targeting the tumor vasculature as a technique for inhibiting tumor growth was first attempted with angiogenesis inhibitors, a class of drugs that compromise the formation of new blood vessels. More recently a new class of drugs called vascular disrupting agents (VDAs) has been reported. Rather than preventing the formation of new blood vessels, VDAs target endothelial cells and pericytes in the already-established vascular network supporting the tumor. VDAs are designed to induce mass...
Source: Prous Science - Molecule of the Month - October 30, 2009 Category: Chemistry Source Type: info

Weak intra- and intermolecular interactions in a binaphthol imine: an experimental charge-density study on (±)-8′-benzhydrylideneamino-1,1′-binaphthyl-2-olEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The charge density in (±)-8′-benzhydrylideneamino-1,1′-binaphthyl-2-ol (1) has been studied experimentally using Mo Kα X-ray diffraction at 100 K, and by theory using density-functional thoery (DFT) calculations at the B3LYP/6-311++G** level. The nature of the weak intramolecular peri-C...N, CH...π, H...H and C(π)...C(π) interactions has been examined by topological analysis using the Quantum Theory of Atoms in Molecules (QTAIM) approach. An analysis of the density ρ(r), the Laplacian of the density ∇2ρ(rb) and other topological properties at the bond-critical points were used to classify these interaction...
Source: Acta Crystallographica Section B - October 27, 2009 Category: Chemistry Authors: Farrugia, L.J.Kočovský, P.Senn, H.M.Vyskočil, Š. Tags: charge-density study density-functional theory topological properties bond-critical points inter- and intramolecular interactions research papers Source Type: journals

Anthrax Probe Under ScrutinyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Microscope could make spectral imaging more accessible. (Source: Analytical Chemistry News and Features)
Source: Analytical Chemistry News and Features - August 20, 2009 Category: Chemistry Source Type: news

New clues in contact lens solution fungal outbreakEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A conversation with John Bullock at Wright State University. Bullock describes work that suggests improper storage of Bausch & Lomb’s ReNu with MoistureLoc may have caused a global fungal infection outbreak. (Source: Analytical Chemistry News and Features)
Source: Analytical Chemistry News and Features - February 26, 2009 Category: Chemistry Source Type: news

[Enzyme Catalysis and Regulation] Protein-Protein Docking and Analysis Reveal That Two Homologous Bacterial Adenylyl Cyclase Toxins Interact with Calmodulin DifferentlyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Calmodulin (CaM), a eukaryotic calcium sensor that regulates diverse biological activities, consists of N- and C-terminal globular domains (N-CaM and C-CaM, respectively). CaM serves as the activator of CyaA, a 188-kDa adenylyl cyclase toxin secreted by Bordetella pertussis, which is the etiologic agent for whooping cough. Upon insertion of the N-terminal adenylyl cyclase domain (ACD) of CyaA to its targeted eukaryotic cells, CaM binds to this domain tightly (~200 pm affinity). This interaction activates the adenylyl cyclase activity of CyaA, leading to a rise in intracellular cAMP levels to disrupt normal cellular signali...
Source: Journal of Biological Chemistry - August 22, 2008 Category: Chemistry Authors: Guo, Q., Jureller, J. E., Warren, J. T., Solomaha, E., Florian, J., Tang, W.-J. Tags: Enzyme Catalysis and Regulation Source Type: journals

DFT Study of Hydrogen Storage by Spillover on Graphite with Oxygen Surface GroupsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of the American Chemical Society, Volume 131, Issue 42, Page 15133-15135, October 28, 2009. (Source: Journal of the American Chemical Society)
Source: Journal of the American Chemical Society - October 21, 2009 Category: Chemistry Tags: article Source Type: journals

Entropic trends in aqueous solutions of the common functional groupsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sheeba Jem Irudayam, Richard D. Plumb, Richard H. Henchman (Paper from Faraday Discuss.) Sheeba Jem Irudayam, Faraday Discuss., 2010, DOI: 10.1039/b907383c To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Faraday Discuss. latest articles)
Source: RSC - Faraday Discuss. latest articles - October 23, 2009 Category: Chemistry Authors: Sheeba Jem IrudayamRichard D. Plumb Richard H. Henchman Source Type: journals

12-O-Tetradecanoylphorbol-13-acetate Inhibits Melanoma Growth by Inactivation of STAT3 through Protein Kinase C-activated Tyrosine Phosphatase(s) [Molecular Basis Of Cell and Developmental Biology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the involvement of the signal transducer and activator of transcription 3 (STAT3) in the TPA-induced growth inhibition of melanoma cells was examined. The in vitro growth and DNA synthesis of five melanoma cell lines, whose STAT3 was activated (phosphorylated), was inhibited by TPA, whereas that of WM35 and WM39 cells, whose STAT3 activity was at negligible levels, was considerably slow and not affected by TPA. Blockade of STAT3 activity by small interfering RNAs suppressed the growth of WM1205Lu cells containing constitutively activated STAT3. Treatment of WM1205Lu cells with TPA decreased both the phosphor...
Source: Journal of Biological Chemistry - October 23, 2009 Category: Chemistry Authors: Oka, M., Sumita, N., Sakaguchi, M., Iwasaki, T., Bito, T., Kageshita, T., Sato, K.-i., Fukami, Y., Nishigori, C. Tags: Molecular Basis Of Cell and Developmental Biology Source Type: journals

Octahedral tilt twinning and compositional modulation in NaLaMgWO6Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A combination of selected-area electron diffraction (SAED), neutron powder diffraction (NPD) and high-resolution transmission electron microscopy (HRTEM) reveals a complex superstructure in the ordered perovskite NaLaMgWO6. Through indexing of SAED patterns the unit-cell dimensions are found to be 46.8 × 7.8 × 7.9 Å, which corresponds to a 12ap × 2ap × 2ap superstructure of the simple Pm\overline 3 m perovskite unit cell. HRTEM images reveal the formation of an unmistakable stripe contrast that repeats with the same periodicity. Doubling of the b and c axes is brought about by a combination of layered ordering of Na...
Source: Acta Crystallographica Section B - October 27, 2009 Category: Chemistry Authors: King, G.Garcia-Martin, S.Woodward, P.M. Tags: twinning modulation neutron powder diffraction electron diffraction electron microscopy research papers Source Type: journals

Speckled-like Pattern in the Germinal Center (SLIP-GC), a Nuclear GTPase Expressed in Activation-induced Deaminase-expressing Lymphomas and Germinal Center B Cells [Dna: Replication, Repair, Recombination, and Chromosome Dynamics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We identified a novel GTPase, SLIP-GC, with expression limited to a few tissues, in particular germinal center B cells. It lacks homology to any known proteins, indicating that it may belong to a novel family of GTPases. SLIP-GC is expressed in germinal center B cells and in lymphomas derived from germinal center B cells such as large diffuse B cell lymphomas. In cell lines, SLIP-GC is expressed in lymphomas that express activation-induced deaminase (AID) and that likely undergo somatic hypermutation. SLIP-GC is a nuclear protein, and it localizes to replication factories. Reduction of SLIP-GC levels in the Burkitt lymphom...
Source: Journal of Biological Chemistry - October 23, 2009 Category: Chemistry Authors: Richter, K., Brar, S., Ray, M., Pisitkun, P., Bolland, S., Verkoczy, L., Diaz, M. Tags: Dna: Replication, Repair, Recombination, and Chromosome Dynamics Source Type: journals

Phosphorothioate-stimulated uptake of siRNA by mammalian cells: a novel route for delivery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The efficient delivery of biologically functional short interfering RNA (siRNA) in vivo remains a widely unresolved technical problem in therapeutic drug development. The repertoire of concepts for the cellular uptake of oligonucleotide-based tools and drugs has been extended by the mechanistically novel finding that phosphorothioate (PS)-modified single-stranded oligodeoxyribonucleotides (ON) promote the intracellular accumulation of naked extra-cellular siRNA in a variety of cell types. This mode of delivery gives rise to substantial intracellular amounts of siRNA, up to 10(4) siRNA molecules per cell. Conversely, th...
Source: Current Topics in Medicinal Chemistry - October 30, 2009 Category: Chemistry Authors: Detzer A, Sczakiel G Tags: Curr Top Med Chem Source Type: journals

Di-μ-oxido-bis{bis[N,N′-bis(2-pyridylmethyl)ethane-1,2-diamine]manganese(III,IV)} tris(perchlorate) hexahydrate: clarification of an order–disorder phase transitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The title compound, [Mn2O2(C14H18N4)2](ClO4)3·6H2O, contains a mixed-valent MnIII/MnIV complex. In accordance with a previous report [Collins, Hodgson, Michelsen & Towle (1987). J. Chem. Soc. Chem. Commun. pp. 1659–1660], the structure at 295 K is best described in the space group C2/c, with the complex exhibiting twofold rotational symmetry, and with half site occupancy for one perchlorate anion and several solvent water molecules. At 180 K, the structure is ordered in the subgroup P21/n and is clearly shown to be a hexahydrate, rather than the previously reported trihydrate. The origin of the order–disorder phas...
Source: Acta Crystallographica Section C - October 23, 2009 Category: Chemistry Authors: Nielsen, A.McKenzie, C.J.Bond, A.D. Tags: metal-organic compounds Source Type: journals