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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.

Nonpharmacological interventions for pain management in paramedicine and the emergency setting: a review of the literature.
Authors: Pak SC, Micalos PS, Maria SJ, Lord B Abstract Paramedicine and the emergency medical services have been moving in the direction of advancing pharmaceutical intervention for the management of pain in both acute and chronic situations. This coincides with other areas of advanced life support and patient management strategies that have been well researched and continue to benefit from the increasing evidence. Even though paramedic practice is firmly focused on pharmacological interventions to alleviate pain, there is emerging evidence proposing a range of nonpharmacological options that can have an important ...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Protective effects of N-acetyl-L-cysteine in human oligodendrocyte progenitor cells and restoration of motor function in neonatal rats with hypoxic-ischemic encephalopathy.
Conclusion. The results indicate that NAC exerts neuroprotective effects in vitro and in vivo by preserving OPCs, via regulation of antiapoptotic signaling, and that F3.Olig2 human OPCs could be a good tool for screening of candidates for demyelinating diseases. PMID: 25918547 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antiproliferative and Apoptosis-Inducing Activities of 4-Isopropyl-2,6-bis(1-phenylethyl)phenol Isolated from Butanol Fraction of Cordyceps bassiana.
In this study, therefore, we examined the anticancer activity of 5 isolated compounds derived from the butanol fraction (Cb-BF) of Cordyceps bassiana. For this purpose, several cancer cell lines such as C6 glioma, MDA-MB-231, and A549 cells were employed and details of anticancer mechanism were further investigated. Of 5 compounds isolated by activity-guided fractionation from BF of Cb-EE, KTH-13, and 4-isopropyl-2,6-bis(1-phenylethyl)phenol, Cb-BF was found to be the most potent antiproliferative inhibitor of C6 glioma and MDA-MB-231 cell growth. KTH-13 treatment increased DNA laddering, upregulated the level of Annexin V...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Ginsenoside Rh1 Improves the Effect of Dexamethasone on Autoantibodies Production and Lymphoproliferation in MRL/lpr Mice.
In conclusion, our data suggest that Rh1 may enhance the effect of Dex in the treatment of MRL/lpr mice through regulating CD4+ T cells activation and Th1/Th2 balance. PMID: 25918545 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antioxidant and hypolipidemic potential of aged garlic extract and its constituent, s-allyl cysteine, in rats.
Authors: Asdaq SM Abstract Aged garlic extract (AGE) is one of the unique preparations standardized with 100% bioavailable active ingredients found in the bloodstream. The current research was aimed at exploring the role of AGE and its chief active constituent, s-allyl cysteine (SAC) as antioxidant and hypolipidemic agent in rats. At the end of treatment of AGE and SAC, separated serum and freshly prepared liver tissue homogenate were analyzed for biochemical enzymes and biomarkers to evaluate and compare potencies of investigational agents. Both AGE and SAC significantly declined elevated levels of triglyceride, t...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

1,2,3,4,6-Penta-O-galloylglucose within Galla Chinensis Inhibits Human LDH-A and Attenuates Cell Proliferation in MDA-MB-231 Breast Cancer Cells.
In this study, through bioactivity guided fractionation of the crude extract, the data demonstrate that penta-1,2,3,4,6-O-galloyl-β-D-glucose (PGG) was a primary constituent responsible for hLDH-A inhibition, present at ~9.95 ± 0.34% dry weight. Theoretical molecular docking studies of hLDH-A indicate that PGG acts through competitive binding at the NADH cofactor site, effects confirmed by functional enzyme studies where the IC50 = 27.32 nM was reversed with increasing concentration of NADH. Moreover, we confirm protein expression of hLDH-A in MDA-231 human breast carcinoma cells and show that PGG was toxic (LC50 = 94....
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Comment on "effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial".
Authors: Verma H PMID: 25918542 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antidiarrhoeal Activity of Musa paradisiaca Sap in Wistar Rats.
Authors: Yakubu MT, Nurudeen QO, Salimon SS, Yakubu MO, Jimoh RO, Nafiu MO, Akanji MA, Oladiji AT, Williams FE Abstract The folkloric claim of Musa paradisiaca sap in the management of diarrhoea is yet to be substantiated or refuted with scientific data. Therefore, the aim of the current study was to screen the sap of M. paradisiaca for both its secondary metabolites and antidiarrhoeal activity at 0.25, 0.50, and 1.00 mL in rats. Secondary metabolites were screened using standard methods while the antidiarrhoeal activity was done by adopting the castor oil-induced diarrhoeal, castor oil-induced enteropooling, and...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Type I saikosaponins a and d inhibit osteoclastogenesis in bone marrow-derived macrophages and osteolytic activity of metastatic breast cancer cells.
Authors: Shin JE, Kim HJ, Kim KR, Lee SK, Park J, Kim H, Park KK, Chung WY Abstract Many osteopenic disorders, including a postmenopausal osteoporosis and lytic bone metastasis in breast and prostate cancers, are linked with a hyperosteoclast activity due to increased receptor activator of nuclear factor kappa-B ligand (RANKL) expression in osteoblastic/stromal cells. Therefore, inhibition of RANKL-induced osteoclastogenesis and osteoclast-induced bone resorption is an important approach in controlling pathophysiology of these skeletal diseases. We found that, of seven type I, II, and III saikosaponins isolated fro...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Pharmacological Basis for Traditional Use of the Lippia thymoides.
Authors: Silva FS, Menezes PM, de Sá PG, Oliveira AL, Souza EA, Bamberg VM, de Oliveira HR, de Oliveira SA, Araújo RE, Uetanabaro AP, Silva TR, Almeida JR, Lucchese AM Abstract The aim of this study was to evaluate crude extracts and fractions from leaves and stems of Lippia thymoides and to validate their use in folk medicine. In vitro antioxidant and antimicrobial activities and in vivo wound healing in rats, baker yeast-induced fever in young rats, and acute oral toxicity in mice assays were realized. The crude extracts and their dichloromethane and ethyl acetate fractions had potent radical-scavenging activit...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Advances in the research and development of natural health products as main stream cancer therapeutics.
Authors: Ovadje P, Roma A, Steckle M, Nicoletti L, Arnason JT, Pandey S Abstract Natural health products (NHPs) are defined as natural extracts containing polychemical mixtures; they play a leading role in the discovery and development of drugs, for disease treatment. More than 50% of current cancer therapeutics are derived from natural sources. However, the efficacy of natural extracts in treating cancer has not been explored extensively. Scientific research into the validity and mechanism of action of these products is needed to develop NHPs as main stream cancer therapy. The preclinical and clinical validation o...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Complementary and alternative medicine for diabetes 2014.
Authors: Yang WC, Chang CL, Li CR, Nammi S, Cho WC PMID: 25883672 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Distribution of Flavonoids and Cyclohexenyl Chalcone Derivatives in Conventional Propagated and In Vitro-Derived Field-Grown Boesenbergia rotunda (L.) Mansf.
Authors: Tan BC, Tan SK, Wong SM, Ata N, Rahman NA, Khalid N Abstract The distribution patterns of flavonoids and cyclohexenyl chalcone derivatives in conventional propagated (CP) and in vitro-derived (CPA) field-grown plants of an important medicinal ginger, Boesenbergia rotunda, are described. A total of eight compounds were extracted from six organs (rootlet, rhizome, shoot base, maroon stem, stalk, and leaf) of the CP and CPA plants. Five major chromatographic peaks, namely, alpinetin, pinocembrin, pinostrobin, 4-hydroxypanduratin A, and panduratin A, were consistently observed by high performance liquid chroma...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Safety of chinese herbal medicine for chronic obstructive pulmonary disease.
Authors: Coyle M, Shergis JL, Liu S, Wu L, Zhang AL, Guo X, Lu C, Xue CC Abstract Chinese herbal medicine (CHM) is increasingly used by patients with chronic obstructive pulmonary disease (COPD); however, there has been no systematic evaluation of its safety. This review examined the adverse events (AEs) reported in clinical studies of CHM for COPD. Five English databases (PubMed, Embase, CINAHL, AMED, and CENTRAL) and four Chinese databases (CBM, CNKI, CQVIP, and Wanfang Data) were searched from inception to May 2013. Adverse event data, including nature, severity, author-assigned causality, management, and outcom...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Antiageing Mechanisms of a Standardized Supercritical CO 2 Preparation of Black Jack (Bidens pilosa L.) in Human Fibroblasts and Skin Fragments.
Authors: Dieamant G, Pereda Mdel C, Nogueira C, Eberlin S, Facchini G, Checon JT, Cesar CK, Mussi L, Polezel MA, Martins-Oliveira D, Di Stasi LC Abstract The use of topical retinoids to treat skin disorders and ageing can induce local reactions, while oral retinoids are potent teratogens and produce several unwanted effects. This way, efforts to explore complementary care resources should be supported. Based on this, we evaluate the antiageing effects of a supercritical CO2 extract from Bidens pilosa L. (BPE-CO2A) containing a standardized multicomponent mixture of phytol, linolenic, palmitic, linoleic, and oleic a...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Does scientific evidence for the use of natural products in the treatment of oral candidiasis exist? A systematic review.
Authors: Ferreira GL, Pérez AL, Rocha ÍM, Pinheiro MA, de Castro RD, Carlo HL, Lima Ede O, Castellano LR Abstract In view of the limitations of antifungal agents used in the treatment of oral candidiasis and the wide variety of natural products that have been studied as treatment of this disease, this systematic literature review proposed to evaluate whether scientific evidence attesting to the efficacy of natural products in the treatment of this disease exists. A systematic search in PubMed, MEDLINE, SciELO, Lilacs, and Cochrane Library databases was accomplished using the associations among the keywords Candid...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Ethnopharmacological survey of medicinal plants used by traditional healers and indigenous people in chittagong hill tracts, bangladesh, for the treatment of snakebite.
Authors: Kadir MF, Karmoker JR, Alam MR, Jahan SR, Mahbub S, Mia MM Abstract Snakebites are common in tropical countries like Bangladesh where most snakebite victims dwell in rural areas. Among the management options after snakebite in Bangladesh, snake charmers (Ozha in Bengali language) are the first contact following a snakebite for more than 80% of the victims and they are treated mostly with the help of some medicinal plants. Our aim of the study is to compile plants used for the treatment of snakebite occurrence in Bangladesh. The field survey was carried out in a period of almost 3 years. Fieldwork was under...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Rapid Antidepressant Activity of Ethanol Extract of Gardenia jasminoides Ellis Is Associated with Upregulation of BDNF Expression in the Hippocampus.
Authors: Zhang H, Xue W, Wu R, Gong T, Tao W, Zhou X, Jiang J, Zhang Y, Zhang N, Cui Y, Chen C, Chen G Abstract Ethanol extract of Yueju pill, a Traditional Chinese Medicine herbal formula widely used to treat mood disorders, demonstrates rapid antidepressant effects similar to ketamine, likely via instant enhancement of brain-derived neurotrophic factor (BDNF) expression in the hippocampus. Here we investigated ethanol extracts of the constituent herbs of Yueju responsible for rapid antidepressant effects. Screening with tail suspension test in Kunming mice at 24 hours after a single administration of five individ...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

AP-1-Targeting Anti-Inflammatory Activity of the Methanolic Extract of Persicaria chinensis.
Authors: Hossen MJ, Kim SC, Son YJ, Baek KS, Kim E, Yang WS, Jeong D, Park JG, Kim HG, Chung WJ, Yoon K, Ryou C, Lee SY, Kim JH, Cho JY Abstract In traditional Chinese medicine, Persicaria chinensis L. has been prescribed to cure numerous inflammatory disorders. We previously analyzed the bioactivity of the methanol extract of this plant (Pc-ME) against LPS-induced NO and PGE2 in RAW264.7 macrophages and found that it prevented HCl/EtOH-induced gastric ulcers in mice. The purpose of the current study was to explore the molecular mechanism by which Pc-ME inhibits activator protein- (AP-) 1 activation pathway and med...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Evaluation of the Effects of Some Brazilian Medicinal Plants on the Production of TNF- α and CCL2 by THP-1 Cells.
Authors: Gusman GS, Campana PR, Castro LC, Castilho RO, Teixeira MM, Braga FC Abstract Several plant species are traditionally used in Brazil to treat various inflammatory diseases. Tumor necrosis factor- (TNF-) α and chemokine (C-C motif) ligand 2 (CCL2) are key inflammatory mediators in diseases like rheumatoid arthritis and atherosclerosis, respectively; nevertheless, only a few extracts have been assayed against these targets. We herein report the effect of 19 plant extracts on TNF-α and CCL2 release by lipopolysaccharide- (LPS-) stimulated THP-1 cells, a human monocytic leukemia cell line, along with their r...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Optimization, Composition, and Antioxidant Activities of Exo- and Intracellular Polysaccharides in Submerged Culture of Cordyceps gracilis (Grev.) Durieu & Mont.
Optimization, Composition, and Antioxidant Activities of Exo- and Intracellular Polysaccharides in Submerged Culture of Cordyceps gracilis (Grev.) Durieu & Mont. Evid Based Complement Alternat Med. 2015;2015:462864 Authors: Sharma SK, Gautam N, Atri NS Abstract Under present experiments, EPS and IPS production, monosaccharide composition, and antioxidant activities of C. gracilis were studied for the first time under submerged culture conditions. Effect of different factors on polysaccharides production was studied by orthogonal experiments using one-factor-at-a-time method. Incubation of culture i...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A Standardized Traditional Chinese Medicine Preparation Named Yejuhua Capsule Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Downregulating Toll-Like Receptor 4/Nuclear Factor-κB.
This study demonstrated that YJH exerted potential protective effects against LPS-induced ALI in mice and supported that YJH was a potential therapeutic drug for ALI in clinic. And its mechanisms were at least partially associated with downregulations of TLR4/NF-κB pathways. PMID: 25878714 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Amelioration of Auditory Response by DA9801 in Diabetic Mouse.
Authors: Lee YR, Hong BN, Her YR, Castañeda R, Moon HW, Kang TH Abstract Diabetes mellitus (DM) is a metabolic disease that involves disorders such as diabetic retinopathy, diabetic neuropathy, and diabetic hearing loss. Recently, neurotrophin has become a treatment target that has shown to be an attractive alternative in recovering auditory function altered by DM. The aim of this study was to evaluate the effect of DA9801, a mixture of Dioscorea nipponica and Dioscorea japonica extracts, in the auditory function damage produced in a STZ-induced diabetic model and to provide evidence of the mechanisms involved in ...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Optimization on Preparation Conditions of Salidroside Liposome and Its Immunological Activity on PCV-2 in Mice.
Authors: Feng Y, Zhao X, Lv F, Zhang J, Deng B, Zhao Y, Hu Y, Wang D, Liu J, Lu Y, Bo R, Liu Z Abstract The aim of this study was to optimize the preparation conditions of salidroside liposome with high encapsulation efficiency (EE) and to study the immunological enhancement activity of salidroside liposome as porcine circovirus type 2 virus (PCV-2) vaccine adjuvant. Response surface methodology (RSM) was selected to optimize the conditions for the preparation of salidroside liposome using Design-Expert V8.0.6 software. Three kinds of salidroside liposome adjuvants were prepared to study their adjuvant activity. BA...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Different Proportions of Huangqi (Radix Astragali Mongolici) and Honghua (Flos Carthami) Injection on α-Glucosidase and α-Amylase Activities.
Conclusion. Honghua significantly inhibited α-glucosidase activity compared with Huangqi (P < 0.01). For simultaneous inhibition of α-glucosidase and α-amylase activities, the mixtures at 2 : 1 and 5 : 1 exhibited significant effects compared with those at 20 : 1 (P < 0.01). PMID: 25873983 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research