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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.

Successful treatment of metoprolol-induced cardiac arrest with high-dose insulin, lipid emulsion and extracorporeal membrane oxygenation
Beta-adrenergic antagonist toxicity causes cardiovascular collapse often refractory to standard therapy. Alternative therapies include high-dose insulin, lipid emulsion and venoarterial extracorporeal membrane oxygenation (VA-ECMO).CaseA 47-year-old male ingested ten grams of metoprolol tartrate in a suicide attempt. Upon emergency department (ED) presentation, he was comatose, bradycardic and hypotensive. Glucagon (14mg IV) and vasopressor/inotropic support (epinephrine 0.1 mcg/kg/min, dobutamine 10 mcg/kg/min) were administered. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - January 16, 2015 Category: Emergency Medicine Authors: Jeremiah T. Escajeda, Ken D. Katz, Jon C. Rittenberger Tags: Case Report Source Type: research

Patients¿ experiences and expectations of chiropractic care: a national cross-sectional survey
Conclusions: Overall, patients reported a high level of satisfaction with the benefits of their chiropractic care, although there is a likelihood of bias towards patients with a positive experience of chiropractic. There were no serious adverse reactions; however, patients reported concern about pain, tingling and numbness in the limbs after chiropractic. In general, patients? expectations were being well met. (Source: Chiropractic and Osteopathy)
Source: Chiropractic and Osteopathy - January 16, 2015 Category: Complementary Medicine Authors: Hugh MacPhersonElizabeth NewbronnerRuth ChamberlainAnn Hopton Source Type: research

Randomised controlled trial on the use of acupuncture in adults with chronic, non-responding anxiety symptoms.
CONCLUSIONS: Acupuncture is a promising intervention for patients with chronic anxiety symptoms that have proven resistant to other forms of treatment. PMID: 25595195 [PubMed - as supplied by publisher] (Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society)
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - January 16, 2015 Category: Complementary Medicine Authors: Errington-Evans N Tags: Acupunct Med Source Type: research

Acupuncture for chronic knee pain: a randomized clinical trial. Authors' reply.
s A, Williamson E, Bennell KL PMID: 25595194 [PubMed - as supplied by publisher] (Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society)
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - January 16, 2015 Category: Complementary Medicine Authors: Authors' reply. Tags: Acupunct Med Source Type: research

Intestinal interleukin-10 mobilization as a contributor to the anti-arthritis effect of orally administered madecassoside: A unique action mode of saponin compounds with poor bioavailability.
In conclusion, madecassoside displays anti-arthritis property not by absorption into blood or by its metabolite, but through an intestine-dependent manner. The action can be mediated by, at least partially, the mobilization of IL-10 that originates from small intestines. PMID: 25600909 [PubMed - as supplied by publisher] (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - January 16, 2015 Category: Drugs & Pharmacology Authors: Wang T, Wei Z, Dou Y, Yang Y, Leng D, Kong L, Dai Y, Xia Y Tags: Biochem Pharmacol Source Type: research

Patients’ experiences and expectations of chiropractic care: a national cross-sectional survey
Conclusions Overall, patients reported a high level of satisfaction with the benefits of their chiropractic care, although there is a likelihood of bias towards patients with a positive experience of chiropractic. There were no serious adverse reactions; however, patients reported concern about pain, tingling and numbness in the limbs after chiropractic. In general, patients’ expectations were being well met. (Source: Chiropractic and Manual Therapies)
Source: Chiropractic and Manual Therapies - January 16, 2015 Category: Complementary Medicine Source Type: research

Drs. Jerome Groopman and Pamela Hartzband to speak at NIH on medical decision-making. NCCIH presents "When Experts Disagree: The Art of Medical Decision Making"
Picture:  Media Advisory NCCAM welcomes acclaimed authors Jerome Groopman, M.D. and Pamela Hartzband, M.D., as featured speakers for the sixth annual Stephen E. Straus Distinguished Lecture in the Science of Complementary Health Therapies. The husband-and-wife team will present “When Experts Disagree: The Art of Medical Decision Making.” (Source: NCCAM Featured Content)
Source: NCCAM Featured Content - January 15, 2015 Category: Complementary Medicine Authors: NCCAM Source Type: news

[Business Office Feature] The Art and Science of Traditional Medicine Part 2: Multidisciplinary Approaches for Studying Traditional Medicine
In this second of three special supplements, herbal genomics as a novel approach for revolutionizing research on, and ultimately use of, traditional herbal medicines and other materia medica, as well as advances in their quality control and standardization, is highlighted. A prominent focus is the U.S. Food and Drug Administration’s practical framework for developing botanicals (including traditional medicines) into new drugs based on the same standards as small molecule drugs. The application of mechanistic studies to drug discovery and development from traditional therapies is discussed, with an emphasis on preclinical...
Source: Science: Current Issue - January 15, 2015 Category: Science Authors: Science Magazine (mailto:soleditor at aaas.org) Tags: CUSTOM PUBLISHING OFFICE SPONSORED SUPPLEMENT Source Type: research

Doctor of Alternative Medicine Seema Anand Explains DIY Approach to...
New book reveals easy ways to identify and treat own ailments.(PRWeb January 14, 2015)Read the full story at http://www.prweb.com/releases/2015/01/prweb12441545.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - January 15, 2015 Category: Pharmaceuticals Source Type: news

PC wallpaper user segmentation based on Sasang Typology
Conclusion By proposing the Sasang Typology as a factor in influencing an HCI usage pattern in this study, it can be used to predict the user's HCI experience, or suggest native design methodology that can actively cope with the user's psychological environment. (Source: Integrative Medicine Research)
Source: Integrative Medicine Research - January 15, 2015 Category: Complementary Medicine Source Type: research

Ginseng total saponin attenuates myocardial injury by antioxidative and anti-inflammatory properties
Conclusion These data indicate that GTS mitigates myocardial damage by modulating the biochemical and oxidative stress related to cardiac I/R injury. (Source: Journal of Ginseng Research)
Source: Journal of Ginseng Research - January 15, 2015 Category: Complementary Medicine Source Type: research

Adverse Reactions to Herbal Products: An Analysis of Spontaneous Reports in the Database of the Pharmacovigilance Programme of India
Publication date: Available online 13 January 2015 Source:Journal of Herbal Medicine Author(s): Vivekanandan Kalaiselvan , Archana Saurabh , Ranvir Kumar , G.N. Singh Herbal products (HPs) are widely used as pharmaceutical and neutraceutical agents in India. The existing Pharmacovigilance Programme of India (PvPI) encourages reporting of adverse events related to HPs to monitor their safety. To analyse the reported adverse reactions suspected with the use of HPs all reports submitted to the National Coordination Centre (NCC) for PvPI during the period July2011 - December 2013 were assessed on the probability of a causal ...
Source: Journal of Herbal Medicine - January 15, 2015 Category: Complementary Medicine Source Type: research

Evaluation of Antifungal activity of hydroalcoholic extracts of Citrullus colocynthis fruit
Publication date: Available online 13 January 2015 Source:Journal of Herbal Medicine Author(s): Samaneh Eidi , Hamideh Ghodrati Azadi , Nasrollah Rahbar , Hamid Reza Mehmannavaz Due to the development of resistance to antimicrobial drugs of several multi-drug resistance pathogens, the discovery of new active agents has become a major public health concern. The purpose of this study was to evaluate the antifungal activity of hydroalcoholic extract of Citrullus colocynthis fruits against different Candida and Aspergillus strains. Anti-Candida and anti-Aspergillus effects of the extract were determined by disc diffusion and...
Source: Journal of Herbal Medicine - January 15, 2015 Category: Complementary Medicine Source Type: research

Neuroprotective therapeutics from botanicals and phytochemicals against Huntington's disease and related neurodegenerative disorders
Publication date: Available online 13 January 2015 Source:Journal of Herbal Medicine Author(s): Abhijit Dey , JitendraNath De Medical herbalism has been popularized due to its reported efficacy, lesser side effects and synergistic interactions against complex syndromes. Herbal medicines are used in neurological disorders in ancient traditional systems in India, China, Japan and Korea. We retrieved and analyzed the research into anti-Huntington's neuroprotective therapeutics from plant sources investigated in neurotoxic models and transgenics in vitro and in vivo studies to provide future references for basic, pre-clinica...
Source: Journal of Herbal Medicine - January 15, 2015 Category: Complementary Medicine Source Type: research

The combination of “Pimpinella Anisum, Apium Graveolens and Crocus Sativus (PAC)” is more effective than “Mefenamic acid” on postpartum after-pain
This study aims to compare the analgesic effects of “a combination of Pimpinella Anisum, Apium Graveolens, and Crocus Sativus (PAC)” with “Mefenamic acid (MA)” on postpartum after-pain. This was a randomized clinical trial on 108 puerperal women aged 25.8±5.5 years old. The participants were randomly divided into two groups of 54 users of PAC or MA (250mg) PAC capsules 500) mg(contained dried powdered extracts of Pimpinella Anisum (60.1mg), Apium Graveolens (16.1mg) and Crocus Sativus (4.1mg) (anise, celery and saffron, respectively) and additional lactose (419.7mg). The capsules were administered every 6hours, up...
Source: Journal of Herbal Medicine - January 15, 2015 Category: Complementary Medicine Source Type: research

In vitro and in silico study of Piper nigrum on cyclooxygenase-2, inducible nitric oxide synthase and antioxidant enzymes
Publication date: Available online 13 January 2015 Source:Journal of Herbal Medicine Author(s): Sarmistha Saha , Ramtej J. Verma The antioxidant potential of the polyphenolic fruit extract of Piper nigrum (Piperaceae), a well known medicinal plant was evaluated. This evaluation was carried out via a reducing power assay; 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide and superoxide radical assays; and a hydrogen peroxide scavenging assay under in vitro conditions and compared with that of the standard reference compound, ascorbic acid. Moreover the phytochemical characterization of the extract was also measured by de...
Source: Journal of Herbal Medicine - January 15, 2015 Category: Complementary Medicine Source Type: research

Characterizing the human equivalent dose of herbal medicines in animal toxicity studies
Conclusions Our results provide important information regarding the safe dose of herbal medicines; thus, these data offer researchers and practitioners information critical for drug development or clinical application. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - January 15, 2015 Category: Drugs & Pharmacology Source Type: research

Are meta-analyses of Chinese herbal medicine trials trustworthy and clinically applicable? A cross-sectional study
Conclusions There are rooms for improvement in methodological rigor, and in choosing clinically homogenous interventions and control for statistical pooling. These shortcomings limit the trustworthiness and clinical applicability of existing MA on CHM trials. To overcome the limitations of pair-wise meta-analysis in synthesizing trials comparing different CHM and control interventions, the potential of network meta-analysis should be explored. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - January 15, 2015 Category: Drugs & Pharmacology Source Type: research

Herbal medicine in the Marquesas Islands
Conclusions An overview of the Marquesan pharmacopoeia, linked with ethnomedicinal practices, is presented in this paper. Marquesan traditional medicine survived until now despite the culture shock faced by the Marquesan population switching to numerous introduced plants commonly found in their close environment and easily gathered. Marquesan herbal medicine appears to draw its inspiration from a common Polynesian root. However further investigations on Marquesan nosologies are necessary to appreciate the originality of the Marquesan pharmacopoeia. Finally, the crossing of ICF and RF indices shows that 36 species have at l...
Source: Journal of Ethnopharmacology - January 15, 2015 Category: Drugs & Pharmacology Source Type: research

Polysaccharides of Dendrobium officinale Induce Aquaporin 5 Translocation by Activating M3 Muscarinic Receptors
Planta MedDOI: 10.1055/s-0034-1383411 Dendrobium officinale is an herbal medicine that has been clinically used to promote body fluid production. Previous works demonstrated that D. officinale polysaccharides could ameliorate symptoms of salivary secretion of patients with Sjögrenʼs syndrome and in a respective mice model. In the present study, we investigated the underlying mechanism by which D. officinale polysaccharides activate M3 muscarinic receptors and induce extracellular calcium influx, leading to the translocation of aquaporin 5, a water channel protein, to the apical membrane of human submandibular gland...
Source: Planta Medica - January 15, 2015 Category: Drugs & Pharmacology Authors: Lin, XiangLiu, JingyiChung, WingyanSze, Stephen Cho-WingLi, HaiyanLao, LixingZhang, Yanbo Tags: Original Papers Source Type: research

The herbal-derived honokiol and magnolol enhances immune response to infection with methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA).
In conclusion, honokiol and magnolol may be considered as attractive immune-modulating treatment for S. aureus infection. PMID: 25586586 [PubMed - as supplied by publisher] (Source: Applied Microbiology and Biotechnology)
Source: Applied Microbiology and Biotechnology - January 15, 2015 Category: Microbiology Authors: Choi EJ, Kim HI, Kim JA, Jun SY, Kang SH, Park DJ, Son SJ, Kim Y, Shin OS Tags: Appl Microbiol Biotechnol Source Type: research

Antioxidative Capacity of a Dietary Supplement on Retinal Hemodynamic Function in a Human Lipopolysaccharide (LPS) Model [Physiology and Pharmacology]
Conclusions. The present data indicate restoring of the RBC flow response to 100% O2 after LPS administration. This is likely due to an amelioration of endothelial dysfunction resulting from oxidative stress, a factor involved in AMD pathophysiology. (ClinicalTrials.gov number, NCT00914576.) (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - January 15, 2015 Category: Opthalmology Authors: Told, R., Schmidl, D., Palkovits, S., Boltz, A., Gouya, G., Wolzt, M., Witkowska, K. J., Popa-Cherecheanu, A., Werkmeister, R. M., Garhofer, G., Schmetterer, L. Tags: Physiology and Pharmacology Source Type: research

5 Steps in Talking With Patients About Alternative Medicine
(MedPage Today) -- Ask, explain, respect, collaborate, compromise. (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - January 14, 2015 Category: American Health Source Type: news

HOMEOPATHIC ALLERGY FORMULA (Allium Cepa, Apis Mellifica, Arsenicum Album, Euphrasia Officinalis, Nux Vomica) Tablet [Indiana Botanic Gardens]
Updated Date: Jan 14, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - January 14, 2015 Category: Drugs & Pharmacology Source Type: news

2015: The Year of the Ministry of Wellness?
Co-authored by Renee Moorefield, CEO, Wisdom Works Feel ill? Head to the doctor. Get diagnosed. Treat the issue. (Also known as: Douse with meds. Take a few days off work. Stumble back to the office. Repeat.) Sound familiar? For too long, discussions about wellness have centered on traditional medical treatments, and Western healthcare systems have maintained a focus on illness and disease, making our hospitals and clinics more like "fix-it shops" than agents of prevention. It's time for a change. And it's time governments around the world not only recognize that prevention is the key to wellness but also begin to do so...
Source: Healthy Living - The Huffington Post - January 14, 2015 Category: Consumer Health Advice Source Type: news

Seasonal and geographical variations in the biochemical composition of the blue mussel (Mytilus edulis L.) from Ireland
Publication date: 15 June 2015 Source:Food Chemistry, Volume 177 Author(s): Ayoa Fernández , Ulrike Grienke , Anna Soler-Vila , Freddy Guihéneuf , Dagmar B. Stengel , Deniz Tasdemir Blue mussel (Mytilus edulis L.) farming constitutes the largest volume of the shellfish sector in Ireland. Recently, interest in mussel dietary supplements and functional foods has increased significantly. To identify the optimal harvesting time and location in Ireland, blue mussels were investigated for their biochemical composition over a period of one year. The study included samples from aquaculture facilities, wild grown mussels and wa...
Source: Food Chemistry - January 14, 2015 Category: Food Science Source Type: research

Epinephrine Use in Positive Oral Food Challenges Performed as Screening Test for Food Allergy Therapy Trials
Conclusions Screening OFCs to confirm food allergies can be performed safely, but there was a higher rate of epinephrine use compared with OFCs used for assessing food allergy outgrowth. Therefore, personnel skilled and experienced in the recognition of early signs and symptoms of anaphylaxis who can promptly initiate treatment are required. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 14, 2015 Category: Allergy & Immunology Source Type: research

Risk of Stroke After Chiropractic Spinal Manipulation in Medicare B Beneficiaries Aged 66 to 99 Years With Neck Pain
The purpose of this study was to quantify risk of stroke after chiropractic spinal manipulation, as compared to evaluation by a primary care physician, for Medicare beneficiaries aged 66 to 99 years with neck pain. (Source: Journal of Manipulative and Physiological Therapeutics)
Source: Journal of Manipulative and Physiological Therapeutics - January 14, 2015 Category: Complementary Medicine Authors: James M. Whedon, Yunjie Song, Todd A. Mackenzie, Reed B. Phillips, Timothy G. Lukovits, Jon D. Lurie Source Type: research

The ginsenosides of promote hair growth via similar mechanism of minoxidil
Panax ginseng (PG) is one of the most famous traditional herbal medicines, and its major active components are known as ginsenosides which have various pharmacological functions [1,2]. It has been reported that PG promote hair growth in several mouse models by preventing apoptosis of hair follicle cells and inhibiting 5α-reductase [3–5]. A recent clinical study showed that topical application of Korean red ginseng extract with 3% minoxidil improved female pattern alopecia [6]. However, these previous studies were not sufficient to investigate the mechanism and efficacy of PG on human hair growth. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - January 14, 2015 Category: Dermatology Authors: Su Na Kim, Sehyun Kim, Yong Deog Hong, Hyeokgon Park, Seung Hyun Shin, Ah Reum Kim, Byung Cheol Park M.D., Song Seok Shin, Jun-Seong Park, Miyoung Park, Young Ho Park, Hae Kwang Lee, John Hwan Lee, Won Seok Park Tags: Letter to the Editor Source Type: research

Effect of the novel functional fiber, polyglycoplex (PGX), on body weight and metabolic parameters: a systematic review of randomized clinical trials
The objective of this review was to critically appraise and evaluate the evidence from published randomized clinical trials (RCTs) examining the effectiveness of polyglycoplex (PGX), a novel functional fibre, on body weight and metabolic parameters. (Source: Clinical Nutrition)
Source: Clinical Nutrition - January 14, 2015 Category: Nutrition Authors: Igho J. Onakpoya, Carl J. Heneghan Tags: Meta-analyses Source Type: research

YouTube as a Source of Information on Dialysis: A Content Analysis
ConclusionsViewers favoured misleading videos and patient narratives over scientifically accurate information. Authoritative sources should use popular social media websites to provide relevant and easy‐to‐understand information on dialysis; including patient stories can make this material more engaging. (Source: Nephrology)
Source: Nephrology - January 14, 2015 Category: Urology & Nephrology Authors: Neetika Garg, Anand Venkatraman, Ambarish Pandey, Nilay Kumar Tags: Original Article Source Type: research

Yu Ping Feng San, an Ancient Chinese Herbal Decoction, Induces Gene Expression of Anti‐viral Proteins and Inhibits Neuraminidase Activity
Yu Ping Feng San (YPFS), a Chinese herbal decoction comprised of Astragali Radix (Huangqi), Atractylodis Macrocephalae Rhizoma (Baizhu) and Saposhnikoviae Radix (Fangfeng), has been used clinically for colds and flus; however, the action mechanism of which is not known. Previously, we had demonstrated that YPFS could modulate inflammatory response and phagocytosis in exerting anti‐viral and anti‐bacterial effects. Here, we further evaluated the bioactivities of YPFS in gene expression regulated by interferon (IFN) signaling and neuraminidase activity of influenza virus A. Application of YPFS onto cultured murine macrop...
Source: Phytotherapy Research - January 14, 2015 Category: Biochemistry Authors: Crystal Y.Q. Du, Ken Y.Z. Zheng, Cathy WC Bi, Tina T.X. Dong, Huangquan Lin, Karl W.K. Tsim Tags: Research Article Source Type: research

Effects of Total Flavones from Acanthopanax senticosus on L‐type Calcium Channels, Calcium Transient and Contractility in Rat Ventricular Myocytes
Acanthopanax senticosus (Rupr. et Maxim.) Harms (AS), a traditional herbal medicine, has been widely used to treat ischemic heart disease. However, the underlying cellular mechanisms of its benefits to cardiac function remain unclear. The present study examined the effects of total flavones from AS (TFAS) on L‐type Ca2+ channel currents (ICa‐L) using the whole cell patch‐clamp technique and on intracellular calcium ([Ca2+]i) handling and cell contractility in rat ventricular myocytes with the aid of a video‐based edge‐detection system. Exposure to TFAS resulted in a concentration‐ and voltage‐dependent blocka...
Source: Phytotherapy Research - January 14, 2015 Category: Biochemistry Authors: Shengjiang Guan, Juanjuan Ma, Xi Chu, Yonggang Gao, Ying Zhang, Xuan Zhang, Fenghua Zhang, Zhenyi Liu, Jianping Zhang, Li Chu Tags: Research Article Source Type: research

Surfactant‐coated graphitized multi‐walled carbon nanotubes as the pseudostationary phase in electrokinetic chromatography for the analysis of phytochemical compounds in biological fluids
This article is protected by copyright. All rights reserved (Source: Electrophoresis)
Source: Electrophoresis - January 14, 2015 Category: Biochemistry Authors: Wan Cao, Shuai‐Shuai Hu, Xue‐zhen Ying, Li‐Hong Ye, Jun Cao Tags: Research Paper Source Type: research

Effect of the novel functional fibre, polyglycoplex (PGX), on body weight and metabolic parameters: A systematic review of randomized clinical trials
The objective of this review was to critically appraise and evaluate the evidence from published randomized clinical trials (RCTs) examining the effectiveness of polyglycoplex (PGX), a novel functional fibre, on body weight and metabolic parameters. (Source: Clinical Nutrition)
Source: Clinical Nutrition - January 14, 2015 Category: Nutrition Authors: Igho J. Onakpoya, Carl J. Heneghan Tags: Meta-analyses Source Type: research

DNA barcoding for species identification from dried and powdered plant parts: A case study with authentication of the raw drug market samples of Sida cordifolia.
Abstract The majority of the plant materials used in herbal medicine is procured from the markets in the form of dried or powdered plant parts. It is essential to use authentic plant materials to derive the benefits of herbal medicine. However, establishing the identity of these plant materials by conventional taxonomy is extremely difficult. Here we report a case study in which the species identification of the market samples of Sida cordifolia was done by DNA barcoding. As a prelude to species identification by DNA barcoding, 13 species of Sida were collected, and a reference DNA barcode library was developed usi...
Source: Gene - January 14, 2015 Category: Genetics & Stem Cells Authors: Vassou SL, Kusuma G, Madasamy P Tags: Gene Source Type: research

Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives.
Abstract Chrysin, a naturally occurring flavone, abundantly found in numerous plant extracts including propolis and in honey is one of the most widely used herbal medicine in Asian countries. Nowadays, chrysin has become the foremost candidate exhibiting health benefits, owing to its multiple bioactivities such as antioxidant, anti-inflammatory, anti-allergic, anti-diabetic, anti-estrogenic, antibacterial and antitumor activities. Anticancer activity is most promising among the multiple pharmacological effects displayed by chrysin. In vitro and in vivo models have shown that chrysin inhibits cancer growth through i...
Source: Toxicology Letters - January 14, 2015 Category: Toxicology Authors: Kasala ER, Bodduluru LN, Madana RM, Athira KV, Gogoi R, Barua CC Tags: Toxicol Lett Source Type: research

Development and validation of a generic method for quantification of collagen in food supplement tablets using liquid chromatography coupled with time-of-flight mass spectrometry.
Abstract A generic method for the quantification of type II collagen in protein-based dietary supplements is described. This quantitative analysis was conducted using liquid chromatography-electrospray ionization-time-of-flight mass spectrometry (LC-ESI-TOF MS). Compared to classical methods with the use of isotope-labeled standards, our method includes, for the first time, the quantification of hydroxyproline using histidine as an internal standard. Separation of the analytes was performed on a Phenomenex Synergi 4 μm Fusion-RP 80 Ǻ column (150 × 2.0 mm, 4.0 μm) with a mobile phase made of 10 mM ammo...
Source: Analytical and Bioanalytical Chemistry - January 14, 2015 Category: Chemistry Authors: Vatansever B, Senal MO, Akgoz M, Goren AC Tags: Anal Bioanal Chem Source Type: research

The effect of 4,5-epoxy-10,14-dihydro-inuviscolide, a novel immunosuppressant isolated from Carpesium abrotanoides, on the cytokine profile in vitro and in vivo.
Abstract The plant Carpesium abrotanoides (CA) is used in Asian herbal medicines as an insecticide and to treat bruises. However, the effect of single compounds from CA blooms and the mechanism of its immunosuppressive effect remain poorly understood. The aim of this study was to investigate the mechanism of the immunosuppressive effect in the three kinds of immune cells, and the immunosuppressive effect of CA bloom extract (CAE) in acute inflammation models (LPS and ConA-induced inflammation). Interleukin-6, IL-4, IL-13, IFNγ, and IL-10-but not TNFα-were significantly reduced in a dose-dependent manner by 4α,5...
Source: International Immunopharmacology - January 14, 2015 Category: Allergy & Immunology Authors: Ko YE, Oh SR, Song HH, Ryu HW, Ly SY, Kim JW Tags: Int Immunopharmacol Source Type: research

Developing Therapies for Peanut Allergy
Peanut allergy is an IgE-mediated, persisting immune disorder that is of major concern worldwide. Currently, no routine immunotherapy is available to treat this often severe and sometimes fatal food allergy. Traditional subcutaneous allergen immunotherapy with crude peanut extracts has proven not feasible due to the high risk of severe systemic side effects. The allergen-specific approaches under preclinical and clinical investigation comprise subcutaneous, oral, sublingual and epicutaneous immunotherapy with whole-peanut extracts as well as applications of hypoallergenic peanut allergens or T cell epitope peptides. Allerg...
Source: International Archives of Allergy and Immunology - January 13, 2015 Category: Allergy & Immunology Source Type: research

DART–TOF–MS based metabolomics study for the discrimination analysis of geographical origin of Angelica gigas roots collected from Korea and China
Abstract Rapid and efficient identification of the geographical origin of Angelica gigas roots (dang-gui) was performed using DART–TOF–MS (direct analysis in real time–time of flight–mass spectrometry) based metabolomics. As an ambient desorption/ionization technique, DART–TOF–MS can provide soft ionization and rapid analysis of samples with little sample preparation so it has been advantageously applied to high-throughput metabolomics analysis. In order to develop an efficient tool for discriminating, particularly geographical origin of raw herbal medicine, we employed DART–TOF–MS fingerprinting ...
Source: Metabolomics - January 13, 2015 Category: Biology Source Type: research

A quality dietary supplement: before you start and after it’s marketed—a conference report
Abstract Consumers worldwide are turning to dietary supplements as one part of their personal goal to lead healthier and more active lives. In truth, the quality of life now supersedes the length of life as no one would trade living to one hundred (the last forty with compromised physical abilities and decreased mental acuity) for 80 years of travel, time with family, and intellectual pursuits. If there is the possibility of preventing a disease or debilitating condition through efficient lifestyle changes (additions, subtractions, modifications) and to also avoid the costly and escalating medical and pharmaceuti...
Source: European Journal of Nutrition - January 13, 2015 Category: Nutrition Source Type: research

Gastrodin Alleviates Cerebral Ischemic Damage in Mice by Improving Anti-oxidant and Anti-inflammation Activities and Inhibiting Apoptosis Pathway.
Abstract Gastrodin (GAS), an active constituent of the Chinese herbal medicine Tianma, has anti-oxidant and anti-inflammation activities but its protective effect to the prevention of neurotoxicity induced by ischemic stroke is unclear. In the present study, middle cerebral artery occlusion (MCAO) was used to establish a mice ischemic stroke model. Infarct volume ratio and neurobehavioral score were evaluated, Nissl staining was performed and the expression of cleaved Caspase 3, Bax and B cell lymphoma 2 (Bcl-2) were assessed at 24 h or 7 days after reperfusion. In addition, the total superoxide dismutase (SOD) a...
Source: Neurochemical Research - January 13, 2015 Category: Neuroscience Authors: Peng Z, Wang S, Chen G, Cai M, Liu R, Deng J, Liu J, Zhang T, Tan Q, Hai C Tags: Neurochem Res Source Type: research

Ophiopogonin D: A new herbal agent against osteoporosis
Excessive reactive oxygen species (ROS) play an important role in the development of osteoporosis. Ophiopogonin D (OP-D), isolated from the traditional Chinese herbal agent Radix Ophiopogon japonicus, is a potent anti-oxidative agent. We hypothesized that OP-D demonstrates anti-osteoporosis effects via decreasing ROS generation in mouse pre-osteoblast cell line MC3T3-E1 subclone 4 cells and a macrophage cell line RAW264.7 cells. We investigated OP-D on osteogenic and osteoclastic differentiation under oxidative status. (Source: Bone)
Source: Bone - January 13, 2015 Category: Orthopaedics Authors: Qiang Huang, Bo Gao, Long Wang, Hong-Yang Zhang, Xiao-Jie Li, Jun Shi, Zheng Wang, Jin-Kang Zhang, Liu Yang, Zhuo-Jing Luo, Jian Liu Tags: Original Full Length Article Source Type: research

Medical Reconciliation of Dietary Supplements; Don’t Ask, Don’t Tell
According to the 1994 Dietary Supplement Health and Education Act (DSHEA), a dietary supplement (DS) is intended to supplement the diet; and contains one or more dietary ingredients including vitamins, minerals, herbs or other botanicals, amino acids, and other substances or their constituents. Dietary supplement (DS) use remains prevalent in patient populations who are frequently hospitalized or at risk of hospitalization such as prescription medication users, those with chronic conditions, and the elderly. (Source: Patient Education and Counseling)
Source: Patient Education and Counseling - January 13, 2015 Category: Global & Universal Authors: Paula Gardiner, Ekaterina Sadikova, Amanda C. Filippelli, Laura F. White, Brian W. Jack Tags: Health Care Source Type: research