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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.

Fighting for Wellness: Strategies of Mid-to-older Women Living with Cancer
Abstract A significant portion of older adult cancer patients are using complementary and alternative medicine (CAM ) during and after treatment. I used four case studies to examine the strategies of older adult CAM-using cancer patients to maintain a sense of well-being as they transitioned to a post-treatment phase of life. Data were collected via qualitative interviews. Findings included strategies for financing CAM treatments, dealing with life disruption, and managing the complete nutritional overhaul recommended by their program. Participants worked to achieve new lifestyles and senses of wellness, finding w...
Source: Journal of Cross-Cultural Gerontology - November 13, 2014 Category: Geriatrics Source Type: research

Online NIR detection method and model for extracting Coptis chinensis
Introduction: More and more PAT (Process Analytical Technology) is being used in the production and quality control of Traditional Chinese medicine. NIR and optical fibres can provide rapid, dynamic and non-destructive detection for related process and operation. The aim of the study was to develop an online near-infrared (NIR) detection method and model for extracting Coptis chinensis. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Wen Liu, Hang Song, Yang Yang, Shun Yao Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Quality control of Bulbus Fritillariae Cirrhosae by HPLC-ELSD fingerprint and identification of selected steroidal alkaloids
Introduction: To evaluate the quality control methods of Bulbus Fritillariae Cirrhosae, a simple and reliable HPLC method with evaporative light scattering detector (ELSD) was developed, both for fingerprint analysis and identification of some active constituents (steroidal alkaloids). (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Ben-Gui Ye, Shu Wang Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Top ten causes that can compromise the safety of herbal medicines
Herbal medicines are widely used worldwide, either as primary health care or complementary medicine. The toxicology of most herbs has however not been thoroughly investigated and their safety is generally assumed from long-standing use. Many factors can nevertheless compromise the safety of herbal treatments, ranging from intrinsic factors of quality to external contaminations or various pharmacological/pharmacokinetic interactions. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Amandine Nachtergael, Valerian Bunel, Elizabeth M. Williamson, Olavi Pelkonen, Pierre Duez Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Development of UPLC–MS fingerprint method for the quality control of three rhubarb species
Introduction: Mass spectrometry (MS) has become an ideal tool for the complex analysis of herbal medicines as it can provide high sensitivity and highly specific chemical information. Compared with HPLC-DAD, UPLC–MS can provide more peak capacity, more effective resolution and shorter run time in the chromatographic separation, and more detection sensitivity matching the complex characteristics of ingredient in herbal medicines. At present, HPLC-DAD based data were mostly used for fingerprint analysis, but the data derived from UPLC–MS were almost not introduced into fingerprint analysis. In our study, a novel, rapid a...
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Li Zhang, Haiyu Liu, Lingling Qin, Zhixin Zhang, Xiaoyan Gao Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

The ability of Lonicera confusa to actively incorporate manganese from soil
Manganese (Mn) is a heavy metal which is transported into the soil environment and accumulates without decomposition and can lead to toxic conditions at natural and agricultural sites. The aim of the present study was to investigate the levels of Mn in Lonicera confusa, a herb that is often used as an anti-inflammatory agent. In addition, the absorption of Mn when the plants were exposed to increasing concentrations of Mn was investigated. Plants were grown in the presence of 3 different concentrations of Mn ions in soil for 15 days. The stems and leaves of Lonicera confusa were collected and the Mn content was measured us...
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Huang Dan-na, Wei Xiao-mei, Wu Qing-hua, Zhou Xiao-lei Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Effect of Tween 80 on examining protein in TCM injections with the pharmacopoeia method
Introduction: To investigate the influence Tween 80 of different concentrations has on the Chinese pharmacopoeia method – sulfosalicylic acid turbidimetry was used for examining protein in traditional Chinese medicine (TCM) injections. This was to explore whether the pharmacopoeia method is suitable for inspecting protein in TCM injections containing Tween 80. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Zu Jinyue, Feng Mengxin, Li Li, Xu Wenying, Ma Changhua Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Spectrum-effect relationship of Chaihu-Shu-Gan-San for antidepressant effect based on partial least squares regression analysis
Introduction: To analyze the spectrum-effect relationships between UPLC-MS fingerprint chromatograms and antidepressant effect of different extracts from the formula of Traditional Chinese medicines (TCMs), Chaihu-Shu-Gan-San (CSGS), and to discover active ingredients of CSGS rapidly. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Xing Chang, Meng Yu, Chao Zhou, Hong-mei Jia, Zhong-mei Zou Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Protective effect of Chaihu-Shu-Gan-San on corticosterone-induced lesion in cultured PC12 cells
Introduction: To investigate the protective effect of Chaihu-Shu-Gan-San (CSGS) and its single herbs on corticosterone-induced PC12 cells was the aim of this study. Methods: The neuroprotective effects of CSGS and its single herbs on the injured PC12 cells induced by corticosterone were investigated by morphological observation, MTT determination and LDH detection. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Ming Wu, Hong-mei Jia, Xing Chang, Meng Yu, Zhuo Ma, Zhong-mei Zou Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Antidepressant effect evaluation of the ethanolic extract from the roots of Cyperus rotundus L. on cell membrane chromatography and different depression models
Introduction: The aim of the study was to explore the antidepressant effects and the possible mechanism of the ethanolic extracts of the roots of Cyperus rotundus L. Methods: The immobility time was observed in the tail suspension test (TST) and the forced swimming test (FST) of mice, two behavioral despair animal models were used to evaluate antidepressant effect of the roots of Cyperus rotundus L. Cell membrane chromatography (CMC) and monoamine oxidase A (MAO-A) inhibition experiments were applied to explorer its antidepressant mechanism. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Hong-mei Jia, Zhong-mei Zou Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Eupolyphaga sinensis Walker screened by cell membrane chromatography and its inhibition on Hek293/EGFR cells by modulating the EGFR signaling pathway
Introduction: Nowadays, anti-EGFR drugs have been widely used in clinical practice. The aim of this study was to rapidly screen EGFR antagonists by Hek293/EGFR cell membrane chromatography from Chinese Traditional Medicine. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Bingling Dai, Junpeng Qi, Yanmin Zhang Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Demethyleneberberine decreases nonalcoholic fatty liver diseases in mice
Introduction: Non-alcoholic fatty liver disease (NAFLD) refers to a spectrum of hepatic disorders not due to excess alcohol consumption, which is regarded to act in a “two-hit” model induced by dysregulated lipid metabolism (1st), oxidative stress and proinflammatory cytokines (2nd). Here we introduce a natural product demethyleneberberine (DMB), which exists in Cortex Phellodendri chinensis and is also a major metabolite of berberine (BBR), a widely reported lipid-lowing compound, in vivo. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Xiaoyan Qiang, Lulu Xu, Pengcheng Zhang, Yubin Zhang Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

NMR based metabolomic study of antifatigue effect of Astragali Radix
Introduction: Astragali Radix (AR, Huangqi), a well-known traditional Chinese medicinal plant, has been used for centuries as a reinforcing vital energy herb in China. Previous studies revealed that AR shows obvious antifatigue effect, but its mechanism is poorly understood. In the present work, a NMR based metabolomic approach was applied to study the antifatigue effect of the AR. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Zhen-Yu Li, Pan He, Hai-Feng Sun, Xue-Mei Qin, Guan-Hua Du Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

An exploration for pharmacokinetic studies of cholic acid and hyodeoxycholic acid
In this study, we selected the cholic acid and hyodeoxycholic acid as study objectives, which are the monarch drugs of Qingkailing injection, and designed an experiment based on their properties to observe their endogenous concentration variation in rat plasma, in order to reduce or eliminate their interference to the determination of exogenous content. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Long Peng, Haiyu Liu, Xiaoyan Gao Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

A study on establishing the body of evidence on postmarketing Chinese medicine safety
At present, medical evidence grading and classification are mainly applied to effectiveness studies of drugs; the systems for evidence grading have a number of limitations when they are applied in the bio-medical field; in addition, there are also many problems arising when they are introduced into the research field of Chinese medicines (CMs). There are very few studies reporting the evidence grading and classification of postmarketing drug safety at home and abroad, so, systematical collection and evaluation of evidence of postmarketing drug safety are of important significance. Drawing on the successful experience in ev...
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Yanming Xie, Xing Liao, Lu Peng-fei Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Quantitative determination of pinocembrin-7-O-β-D-glucoside and its metabolite in rat plasma by liquid chromatography–tandem mass spectrometry and its application in a pharmacokinetic study
Introduction: Pinocembrin-7-O-β-D-glucoside (PCBG) and pinocembrin (PCB) are the main constituents isolated from the extract of the aerial part of Penthorum chinense Pursh and they show protective effect for liver. The aim of this study was to develop and validate a simple, rapid and sensitive UFLC-ESI-MS/MS method for the quantitative determination of PCBG and its metabolite PCB simultaneously in rat plasma, and its application in a pharmacokinetic study. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Weiwei Guo, Xiaoqing Chen, Rong Luo, Haolong Liu, Meng Wang, Xia Wu, Huan He Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Comparative pharmacokinetic study of ligustilide after administration of Angelica Sinensis and xiaoyaosan petroleum ether fraction
Introduction: To compare the pharmacokinetic difference of ligustilide in Angelica Sinensis petroleum ether fraction (AS-P) and xiaoyaosan petroleum ether fraction (XY-P). Methods: A specific ultra-high performance liquid chromatography (UPLC) method was developed and validated for determining the concentration of ligustilide in serum of rats after i.g. administration of AS-P and XY-P. The chromatographic conditions were as follows: The Waters UPLC was equipped with a reversed phase column (BEH C18 2.1mm×100mm, i.d. 1.7μm). The mobile phase was a mixture of acetonitrile and 0.03% trifluoroacetic acid in water with the p...
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Qiao Ya-rong, Liu Jia-li, Yang Lan, Qin Xue-mei, Gao Xiao-xia Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Screening of anticholinesterase activity of the standardized extract of Dillenia indica fruits
Introduction: Dillenia indica (Elephant apple), family Dilleniaceae is abundantly used in various food preparations in India. D. indica fruit is used in various traditional medicinal preparations for its anti-leukemic, anxiolytic, antioxidant and neuro-protective activities. The medicinal activities of D. indica suggest that it might exert beneficial effects on cognitive disorders. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Santanu Bhadra, Manoj K. Dalai, Joydeb Chanda, Amit Kar, Pulok K. Mukherjee Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Open field test: Behaviors response to experimental timing during circadian variation in postpartum depression rats
Introduction: The ethological evaluation of postpartum depression (PPD) rats treated with Shen-Qi-Jie-Yu-Fang has been previously reported, using modeling with hormone simulated pregnancy (HSP) and measured with open-field test (OFT). However, the impact of circadian rhythmicity with PPD rats has received little attention in OFT. In this paper, the effect of light–dark cycle rhythm was observed on the response of PPD rats. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Qisheng Tang, Ruizhen Zhao, Miao Qu, Xinke Yang Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Roles of Shen-Qi-Jie-Yu-Fang in postpartum depression rats: Ethological evaluation of anhedonia and underlying motivation
Introduction: Therapy of postpartum depression (PPD) in Traditional Chinese Medicine (TCM) includes tonifying deficiency, removing blood stasis, nourishing brain and inducing resuscitation. Thereby, Shen-Qi-Jie-Yu-Fang (SJ) was established by our team leader Dr. Tang. Although, the depressive-like symptoms of PPD rats were different in performance during circadian rhythmicity, the behavior response after intervention with SJ Fang was unknown. In this paper, the impact of SJ Fang was observed on underlying motivation in a novel environment at light and dark phases. Additionally, the improvement of SJ Fang was researched on ...
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Ruizhen Zhao, Miao Qu, Qisheng Tang, Xinke Yang Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Effect of compound danshen preparation on the plasma and heart concentrations of cytochrome P-450 metabolites of arachidonic acid in rats with myocardial ischemia and reperfusion
Introduction: Cardiovascular disease (CVD) is a human health crisis that remains the leading cause of death worldwide. The cytochrome P450 (CYP450) enzymes are key metabolizers of both xenobiotics and endobiotics. Recently, accumulating data had exhibited the fact that CYP450 metabolites resulting from epoxidation of arachidonic acid (AA), including 5,6-, 8,9-, 11,12- and 14,15-epoxyeicosatrienoic acid (EETs), reduce ischemic and reperfusion injury (IRI) in the heart and vasculature. On the other hand, the hydroxylated metabolite of AA, such as 20-hydroxyeicosatetraenoic acid (20-HETE), is a potent vasoconstrictor and may ...
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Meijuan Xu, Yidan Wei, Lifeng Jiang, Wenzheng Ju, Hui Ji, Haiping Hao, Guangji Wang, Ping Li Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Antimalarial potential and safety of the polyherbal product Nefang
This study aims at investigating the in vivo antiplasmodial activity and safety of Nefang aqueous extract. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Faith A. Okalebo, Lawrence A. Ayong, Tsabang Nole, Gabriel A. Agbor, Anastasia N. Guantai Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Effects of sulfur-fumigation on the global quality of Radix Paeoniae Alba: A quantitative evaluation by improved high performance liquid chromatography
Introduction: Radix Paeoniae Alba (RPA) has post-harvest been handled by sun-drying the whole fresh root after boiling in water and peeling off the skins. But in the near decade, sulfur-fumigation was reported as being used in post-harvest handling of RPA. Extensive studies showed that sulfur-fumigation could induce paeoniflorin transformed into paeoniflorinsulfonate in RPA. An improved HPLC-DAD method for simultaneously quantifying 12 major components of RPA was developed for quantitative evaluation of RPA samples sulfur-fumigated with different durations and purchased from commercial herbal markets. (Source: European Jou...
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Ming Kong, Huan-Huan Liu, Jun Xu, Chun-Ru Wang, Ming Lu, Xiao-Ning Wang, You-Bin Li, Song-Lin Li Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

RN1 binds to galectin-3 to cause pancreatic cancer proliferation inhibition and cell cycle arrested through EGFR-ERK-cyclin D1 signaling pathway
Pancreatic cancer is the fourth leading cause of cancer death in USA, and among all the cancers, it has the highest metastasis rate, 5-year survival is less than 5%. Here we report a novel polysaccharide RN1 purified from the flower of Panax notoginseng which shows anticancer effects using in vitro and in vivo pancreatic cancer models. RN1 inhibited AsPC-1 and BxPC-3 cancer cell proliferation and had no effect on normal pancreatic and liver cells at the tested concentration. Moreover, RN1 caused pancreatic cancer cell cycle arrested at S phase. Interestingly, RN1 significantly reduced xenografted pancreatic tumor size and ...
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Lei Zhang, Peipei Wang, Ping Li, Kan Ding Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Inhibitory effects of dihydrotanshinone I on CYP4A11 and CYP4F3A mediated ω-hydroxylation of arachidonic acid
20-Hydroxyeicosatetraenoic acid (20-HETE), generated mainly by CYP4A and/or CYP4F enzymes, is a ω-hydroxylated metabolite of arachidonic acid (AA) that exhibits a plethora of biological functions. Inhibition of CYP4 enzymes, and thus the biosynthesis of 20-HETE, has been suggested as a therapeutic strategy for several diseases, such as hypertension, ischemia-reperfusion injury, and some cancers because 20-HETE may contribute to the pathogenesis of these conditions. Danshen, the dried root of Salvia miltiorrhiza, has been used for hundreds of years in the treatment of cardiovascular and cerebrovascular diseases in China. H...
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Meijuan Xu, Lifeng Jiang, Wenzheng Ju, Haiping Hao, Guangji Wang, Ping Li Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Synergistic activity of dihydrotanshinone I and ginsenoside Rd combinations in inhibiting tumour necrosis factor-alpha production in RAW264.7 cells
Introduction: Salvia Miltiorrhiza Radix and Rhizoma - Panax Notoginseng Radix (Danshen-Sanqi) combinations are used in traditional Chinese medicine (TCM) to treat cardiovascular complications. It is believed that combining Danshen and Sanqi can enhance the therapeutic efficacy of the single herbs by facilitating synergism. As the major bioactives, dihydrotanshinone I (DT) from Danshen and ginsenoside Rd (Rd) from Sanqi have shown individual anti-inflammatory activity, especially in suppressing tumour necrosis factor-alpha (TNF-α) release. However, the interaction between these bioactives on anti-inflammatory activity has ...
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Xian Zhou, Valentina Razmovski-Naumovski, Antony Kam, Kelvin Chan Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Expert consensus for postmarketing Chinese medicine intensive hospital safety monitoring
It is of vital significance to conduct active postmarketing surveillance of Chinese medicine, as an active response to laws, rules and guidelines issued by the China Food and Drug Administration. These will provide technological support in evaluating adverse drug reactions (ADRs) or adverse drug events (ADEs). The consensus has been developed by drawing on postmarketing safety monitoring of medicines and the advanced design concepts and methodologies from home and abroad, and complying with national laws, regulations and technical guidance documents, whilst taking into consideration the characteristics of CMs and the actua...
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Yan-ming Xie, Xing Liao, Wen Zhang, Feng Tian, Yu-bin Zhao, Ming-quan Li, Yun-ling Zhang, Rong Ma, Shao-xiang Xian, Jian Liu, Su-yun Li, Ze-huai Wen, Zhong-qi Yang, Jian-dong Zou, Hong-sheng Sun, Yan He, Xue-lin Li, Jun-jie Jiang, Zhi-fei Wang, Yuan-yuan Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Toxic and detoxic principles of compatibility of Euphorbia kansui and Zizyphus jujuba in vitro and in vivo
Introduction: The roots of Euphorbia kansui (EK) and the fruits of Zizyphus jujuba (ZJ) have been clinically used in traditional Chinese medicine (TCM) for a long time. This work is to clarify the toxic and detoxic principles that are responsible for the compatibility of EK and ZJ. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Yu-Mei Liu, Cui-Cui He, Rong-Rong Hui, Yue Huai, Jin-Ao Duan, Yu-Ping Tang, Jian-Xin Li Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

A comparative study on the antioxidant activity of Zingiberis Rhizoma raw herb and granule
Introduction: Zingiberis Rhizoma is traditionally used to treat atherosclerosis, arthritis and rheumatologic complications. Zingiberis Rhizoma contains phenolic bioactives including gingerols and shogaols, which are well-known antioxidants. Recently, there is growing trend towards the clinical use of herbal granules due to their portability, and ease of storage and administration. The aim of this study was to compare the antioxidant activity of Zingiberis Rhizoma granules to its raw herb decoction. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: John Truong, Valentina Razmovski-Naumovski, Xian Zhou, Cheang Khoo, Kelvin Chan Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Anti-cancer activities of BF211, a derivative of bufalin
Introduction: Epidemiological data as well as in vitro and in vivo studies indicated that cardiac glycosides have anti-cancer activities and also emphasize the possibility of developing this class of compound as anti-cancer agents. Promising compounds such as Anvirzel and UNBS1450 are now in clinical trials in USA and Belgium, respectively. In China, Chansu, a traditional medicine containing bufadienolides, has long been used for treatment of cancer. Among the bufadienolides, bufalin appears to be the most active. However, its narrow therapeutic window limits its therapeutic application. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Lixing Feng, Lihong Hu, Xuan Liu, Dean Guo Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Therapeutic effects of Benincasa hispida seed extracts on chronic bacterial prostatitis models in rats
Introduction: The effects of three different extracts of B. hispida seeds including water extract (WE), methanol extract (ME), and petroleum extract (PE) in a rat model of CBP, and the underlying mechanisms were studied in this research. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Jing Liu, Pinglin Li, Jie Yan, Bin Li, Xuli Tang, Guoqiang Li Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Salvianolic acid A, a novel matrix metalloproteinase-9 inhibitor, reduces microvascular damage induced by hypertension
Introduction: Despite plenty of pharmacological agents available for hypertension therapy, hypertension-related damage to the microvascular remodeling is not resolved. The present work aimed to investigate the protection of Salvianolic acid A (SalA), a novel matrix metalloproteinase-9 inhibitor, against microvascular remodeling induced by hypertension. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Fukang Teng, Yanping Deng, Dengfang Li, Li Zhang, Tingting Zhang, Jun Yin, Baohong Jiang, De-an Guo Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Fangchinoline targets proteasome β1 subunit to exert its anti-cancer effects
Introduction: In our study screening natural proteasome inhibitors with compounds isolated from traditional Chinese medicines, fangchinoline, a bisbenzylisoquinoline alkaloid isolated from Radix Stephaniae tetrandrae S. Moore (known as Fangji in China), were identified as potent inhibitors for C-L activity of cellular proteasome in PC-3 prostate cancer cells. Fangji is a traditional Chinese medicine used for long time as an antirheumatic, anti-inflammatory and anticancer agent. In the present study, we characterized the inhibiting effects of fangchinoline on proteasome and the involvement of proteasome inhibition in its an...
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Dong Li, Xiaobo Qu, Xuan Liu, Dean Guo Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Anti-metastasis effects of metronomic zoledronate in combination with Coriolus versicolor in mouse intratibial breast cancer model
In this study, we hypothesized that CV would synergistically enhance the action of metronomic ZOL in breast cancer-induced metastasis. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Chun-Hay Ko, Grace Gar-Lee Yue, Si Gao, Wai-Ting Shum, Wing-Sum Siu, Julia Kin-Ming Lee, Kwok-Pui Fung, Ping-Chung Leung, Gang Li, Andreas Evdokiou, Clara Bik-San Lau Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Ginsenoside Rg1 and ginsenoside Rb1 play different role in myocardial infarction rats while combination with salvianolic acid B
Introduction: The herb pair of Salviae miltiorrhizae and Panax notoginseng has been widely used for improving coronary or cerebral circulation in China. However, the exact contribution of the major active components on cardioprotection from Salviae miltiorrhizae and Panax notoginseng is far from clear. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Yanping Deng, Tingting Zhang, Fukang Teng, Defang Li, Feng Xu, Kenka Cho, Jinghua Xu, Jun Yin, Li Zhang, Qian Liu, Ming Yang, Wanying Wu, Xuan Liu, Baohong Jiang, De-an Guo Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

A preliminary assessment of traditional Chinese herbs cytotoxicity and genotoxicity
Introduction: Traditional Chinese herbs, sometimes known for thousands years, are generally considered as safe and reliable when used as directed. However, safety assessment has been performed on only a few herbs, but this can be compromised by various factors (adulteration, contamination). This work proposes to assess the cytotoxicity and genotoxicity of some well-known traditional Chinese herbal medicines and some of their associations. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Amandine Nachtergael, Mélanie Poivre, Alexandra Belayew, Pierre Duez Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

“Gene-to-Metabolite” network prompted engineering of rosmarinic acid biosynthetic pathway in Salvia miltiorrhiza hairy root cultures
This study provides a practical model approach to synthesize valuable secondary metabolites by rational engineering. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Ying Xiao, Lei Zhang, Wansheng Chen Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Isolation and characterization of glycopeptides with analgesic activities from Marasmius androsaceus
Anluotong, which is a traditional medicine and prepared from the mycelium of M. androsaceus, is used in China as an analgesic. But its chemical composition and active components have not been elucidated, hence there is no method for quality control and poor understanding of its modes of action. Herein, our work has shown that the water extract of the mycelium from M. androsaceus contains approximately 30% glycopeptide, which were the primary analgesic materials. The glycopeptides in M. androsaceus were composed of a series of similar glycopeptides that all had analgesic properties. The D2 fraction, isolated by macroporous ...
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Yang Gao, Dan Liu, Xianling Yang, Ruizhi Jiang, Tie Hong, Qipin Gao Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Chemical constituents of Pileostegia viburnoides var. glabrescens
Introduction: Pileostegia viburnoides Hook. f. et Thoms. var. glabrescens (C. C. Yang) S. M. Hwang (Saxifragaceae) is a plant used to dispel wind to eliminate dampness and to eliminate stasis to stop pain in TCM for the treatment of traumatic injury, fractures, multiple abscess, rheumatism and joint soreness. The aim of this study was to isolate its active compounds with anti-inflammatory properties. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Juan Yu, Sheng-huang Chen, Wei Wang, Ju-ying Zou, Qin-wen Li, Xiang-rui Chen, Bing-bing Shen, Min Wang Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Discovery and analysis of GRAS gene family in Isatis indigotica
Isatis indigotica, usually known as Banlangen (Radix Isatidis), is one of the most commonly used plants in traditional Chinese medicine for its anti-inflammatory and antiviral activities. Its leaves which are called “Daqingye” (Folium Isatidis) are also used as herb medicine that can be used for the treatment of epidemic parotitis and erysipelas. In addition, Daqingye is an important material for extraction of indigotin in the dye industry. Given its significant medicinal and economic values and close relationship to Arabidopsis thaliana, the I. indigotica transcription profiling database was recently built up by ourse...
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Qing Li, Junfeng Chen, Peng Di, Ying Xiao, Lei Zhang, Wansheng Chen Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Isolation and characterization of glycopeptides with analgesic activities
To screen and characterize the analgesic components from Marasmius androsaceus, the water-soluble extracts from the mycelium of M. androsaceus were isolated by ethanol precipitation followed by macroporous resin chromatography and activity-based fractionation. Analgesic activities were found to be associated with glycopeptides. The glycopeptide fractions were further purified by gel-permeation chromatography and two purified glycopeptides, D2H, D2L, were obtained. Next, the physicochemical properties and characteristics of these purified glycopeptides were studied. They were composed of glucose and mannose and 10 different...
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Yang Gao, Xianling Yang, Qipin Gao Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Antitussive and expectorant constituents of Reineckiacarnea (Andr.) Kunth
Introduction: Reineckiacarnea (Andr.) Kunth, a kind of traditional ethnic drug, mainly is distributed in Guizhou and Yunnan provinces of southern China, whose aerial part is used for preventing cough, eliminating phlegm, rheumatism disease treatment and hepatitis. We aim to illustrate the active constituents of the aqueous extract of aerial part of Reineckiacarnea by bioassay guided isolation. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Jun Yin, Yichun Wang, Ting Huang, Zhihui Liu, Na Han Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Integrated Omics-based approach toward understanding and regulation of valuable secondary metabolism in medicinal plant
We present herein a broadly applicable rapid biosynthetic gene discovery method using large datasets derived from genomics, transcriptomics, proteomics, and metabolomics to investigate the functions of key gene and transcript factor involved in metabolic network. A case study of gene discovery involved in phenylpropanoids biosynthesis and pathway regulation to engineer high level of active compounds in Isatis indigotica will be presented. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Lei Zhang, Wansheng Chen Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research

Research progress on chemical composition, biological activity, and quality control of Radix Platycodi
Introduction: To provide a basis for further research and utilization of Radix Platycodi, the chemical constituents, biological activity, and quality control were reviewed. Methods: By literature reviewing and compilation of relevant data, literature on its chemical composition, biological activity and quality control studies were collected and analyzed. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2014 Category: Complementary Medicine Authors: Ye Yunyun, Han Lu, Zhang Yan, Sun Jiayou, Zhou Li, Bai Changcai Tags: Abstracts GPTCM –RA and Speciality Committee of TCM Pharmaceutical analysis of WFCMS Source Type: research