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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Dormancy of metastatic melanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Metastatic dormancy of melanoma has not received sufficient attention, most likely because once detectable, metastasis is almost invariably fatal and, understandably, the focus has been on finding ways to prolong life of patients with overt recurrences. Nevertheless, analysis of the published clinical and experimental data on melanoma indicates that some aspect of melanoma biology imitate traits recently associated with dormancy in other solid cancers. Among them the ability of some melanomas to disseminate early during primary tumor progression and once disseminated, to remain undetected (dormant) for years. Comparison of...
Source: Pigment Cell Research - November 11, 2009 Category: Cytology Authors: Liliana Ossowski, Julio A. Aguirre-Ghiso Source Type: journals

So long, and thanks for all the...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19845872 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - October 23, 2009 Category: Cytology Authors: Goding C Tags: Pigment Cell Melanoma Res Source Type: journals

Local lymphogenic migration pathway in normal mouse spleenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Although the immunological and hemodynamical significance of the spleen is of great importance, few reports detail the lymphatic vessels in this organ. We have used an immunohistochemical three-dimensional imaging technique to characterize lymphatic vessels in the normal mouse spleen and have successfully demonstrated their spatial relationship to the blood vascular system for the first time. Lymphatic markers, such as LYVE-1, VEGFR-3, and podoplanin, show different staining patterns depending on their location in the spleen. LYVE-1-positive lymphatic vessels run reverse to the arterial blood flow a...
Source: Cell and Tissue Research - November 6, 2009 Category: Cytology Tags: Cell and Tissue Research Source Type: journals

Phase I Study of Ipilimumab, an Anti-CTLA-4 Monoclonal Antibody, in Patients with Relapsed and Refractory B-Cell Non-Hodgkin Lymphoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Blockade of CTLA-4 signaling with the use of ipilimumab is well tolerated at the doses used and has antitumor activity in patients with B-cell lymphoma. Further evaluation of ipilimumab alone or in combination with other agents in B-cell lymphoma patients is therefore warranted. (Clin Cancer Res 2009;15(20):OF1-8). PMID: 19808874 [PubMed - as supplied by publisher] (Source: Cell Research)
Source: Cell Research - October 5, 2009 Category: Cytology Authors: Ansell SM, Hurvitz SA, Koenig PA, Laplant BR, Kabat BF, Fernando D, Habermann TM, Inwards DJ, Verma M, Yamada R, Erlichman C, Lowy I, Timmerman JM Tags: Clin Cancer Res Source Type: journals

Shocking ... and ... stunning.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19845873 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - October 23, 2009 Category: Cytology Authors: Hammelsoe P Tags: Pigment Cell Melanoma Res Source Type: journals

Effect of Granulocyte/Macrophage Colony-Stimulating Factor on Circulating CD8+ and CD4+ T-Cell Responses to a Multipeptide Melanoma Vaccine: Outcome of a Multicenter Randomized Trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: High immune response rates for this multipeptide vaccine were achieved, but CD8(+) and CD4(+) T-cell responses were lower when administered with GM-CSF. These data challenge the value of local GM-CSF as a vaccine adjuvant in humans. (Clin Cancer Res 2009;15(22):7036-44). PMID: 19903780 [PubMed - as supplied by publisher] (Source: Cell Research)
Source: Cell Research - November 10, 2009 Category: Cytology Authors: Slingluff CL, Petroni GR, Olson WC, Smolkin ME, Ross MI, Haas NB, Grosh WW, Boisvert ME, Kirkwood JM, Chianese-Bullock KA Tags: Clin Cancer Res Source Type: journals

Enhancement of DNA repair using topical T4 endonuclease V does not inhibit melanoma formation in Cdk4R24C/R24C/Tyr-NrasQ61K mice following neonatal UVREmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To further investigate the use of DNA repair-enhancing agents for skin cancer prevention, we treated Cdk4R24C/R24C/NrasQ61K mice topically with the T4 endonuclease V DNA repair enzyme (known as Dimericine) immediately prior to neonatal ultraviolet radiation (UVR) exposure, which has a powerful effect in exacerbating melanoma development in the mouse model. Dimericine has been shown to reduce the incidence of basal-cell and squamous cell carcinoma. Unexpectedly, we saw no difference in penetrance or age of onset of melanoma after neonatal UVR between Dimericine-treated and control animals, although the drug reduced DNA dama...
Source: Pigment Cell Research - October 27, 2009 Category: Cytology Authors: Elke Hacker, H. Konrad Muller, Nicholas Hayward, Paul Fahey, Graeme Walker Source Type: journals

Chapter 6 molecular and cell biology of testicular germ cell tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although testicular germ cell tumors (TGCTs) are relatively uncommon, they are particularly important as they tend to affect children and young men, representing the most common tumor in male aged from 20 to 40years. TGCTs are a heterogeneous group of tumors, with specific peculiarities reflecting on epidemiologic distribution and clinic-pathological features. TGCTs show a high-cure rates in both seminomas and nonseminomas and represent the model of a curable neoplasia: sensitive serum tumor markers, accurate prognostic classification, contribute to a high effectiveness of cancer therapy. However, up to 30% of patients...
Source: International Review of Cell and Molecular Biology - October 10, 2009 Category: Cytology Authors: Chieffi P, Franco R, Portella G Tags: Int Rev Cell Mol Biol Source Type: journals

An Embryonic Stem Cell-Like Signature Identifies Poorly Differentiated Lung Adenocarcinoma but not Squamous Cell Carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This work suggests that not all poorly differentiated non-small cell lung cancers exhibit a gene expression profile similar to that of ESC, and that other characteristics may play a more important role in the determination of differentiation and survival in SCC of the lung. (Clin Cancer Res 2009;15(20):OF1-5). PMID: 19808871 [PubMed - as supplied by publisher] (Source: Cell Research)
Source: Cell Research - October 5, 2009 Category: Cytology Authors: Hassan KA, Chen G, Kalemkerian GP, Wicha MS, Beer DG Tags: Clin Cancer Res Source Type: journals

A Modified Sleeping Beauty Transposon System That Can Be Used to Model a Wide Variety of Human Cancers in Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent advances in cancer therapeutics stress the need for a better understanding of the molecular mechanisms driving tumor formation. This can be accomplished by obtaining a more complete description of the genes that contribute to cancer. We previously described an approach using the Sleeping Beauty (SB) transposon system to model hematopoietic malignancies in mice. Here, we describe modifications of the SB system that provide additional flexibility in generating mouse models of cancer. First, we describe a Cre-inducible SBase allele, RosaSBase(LsL), that allows the restriction of transposon mutagenesis to a specific...
Source: Cell Research - October 5, 2009 Category: Cytology Authors: Dupuy AJ, Rogers LM, Kim J, Nannapaneni K, Starr TK, Liu P, Largaespada DA, Scheetz TE, Jenkins NA, Copeland NG Tags: Cancer Res Source Type: journals

Persistence of Betapapillomavirus Infections as a Risk Factor for Actinic Keratoses, Precursor to Cutaneous Squamous Cell Carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, persistent betaPV infections in this population were associated with an increased occurrence of actinic keratosis. Additional studies are needed to determine the possible association of betaPV persistence with SCC. [Cancer Res 2009;69(23):OF1-6]. PMID: 19903846 [PubMed - as supplied by publisher] (Source: Cell Research)
Source: Cell Research - November 10, 2009 Category: Cytology Authors: Plasmeijer EI, Neale RE, de Koning MN, Quint WG, McBride P, Feltkamp MC, Green AC Tags: Cancer Res Source Type: journals

Partial CD4 Depletion Reduces Regulatory T Cells Induced by Multiple Vaccinations and Restores Therapeutic Efficacy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These results suggest that CD4+ T(reg) cells limit the efficacy of multiple vaccinations and that timed partial depletion of CD4+ T cells may reduce suppression and "tip-the-balance" in favor of therapeutic antitumor immunity. The recent failure of large phase III cancer vaccine clinical trials, wherein patients received multiple vaccines, underscores the potential clinical relevance of these findings. (Clin Cancer Res 2009;15(22):6881-90). PMID: 19903784 [PubMed - as supplied by publisher] (Source: Cell Research)
Source: Cell Research - November 10, 2009 Category: Cytology Authors: Lacelle MG, Jensen SM, Fox BA Tags: Clin Cancer Res Source Type: journals

SKI knockdown inhibits human melanoma tumor growth in vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The SKI protein represses the TGF-beta tumor suppressor pathway by associating with the Smad transcription factors. SKI is upregulated in human malignant melanoma tumors in a disease-progression manner and its overexpression promotes proliferation and migration of melanoma cells in vitro. The mechanisms by which SKI antagonizes TGF-beta signaling in vivo have not been fully elucidated. Here we show that human melanoma cells in which endogenous SKI expression was knocked down by RNAi produced minimal orthotopic tumor xenograft nodules that displayed low mitotic rate and prominent apoptosis. These minute tumors exhibited...
Source: Pigment Cell and Melanoma Research - October 23, 2009 Category: Cytology Authors: Chen D, Lin Q, Box N, Roop D, Ishii S, Matsuzaki K, Fan T, Hornyak TJ, Reed JA, Stavnezer E, Timchenko NA, Medrano EE Tags: Pigment Cell Melanoma Res Source Type: journals

Upregulation of MMP-2 by HMGA1 Promotes Transformation in Undifferentiated, Large-Cell Lung Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although lung cancer is the leading cause of cancer death worldwide, the precise molecular mechanisms that give rise to lung cancer are incompletely understood. Here, we show that HMGA1 is an important oncogene that drives transformation in undifferentiated, large-cell carcinoma. First, we show that the HMGA1 gene is overexpressed in lung cancer cell lines and primary human lung tumors. Forced overexpression of HMGA1 induces a transformed phenotype with anchorage-independent cell growth in cultured lung cells derived from normal tissue. Conversely, inhibiting HMGA1 expression blocks anchorage-independent cell growth in...
Source: Cell Research - November 10, 2009 Category: Cytology Authors: Hillion J, Wood LJ, Mukherjee M, Bhattacharya R, Di Cello F, Kowalski J, Elbahloul O, Segal J, Poirier J, Rudin CM, Dhara S, Belton A, Joseph B, Zucker S, Resar LM Tags: Mol Cancer Res Source Type: journals

AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We reported earlier on the oncogenic properties of Grm1 by demonstrating that stable Grm1-mouse-melanocytic clones proliferate in the absence of growth supplement and anchorage in vitro. In addition, these clones also exhibit aggressive tumorigenic phenotypes in vivo with short latency in tumor formation in both immunodeficient and syngeneic mice. We also detected strong activation of AKT in allograft tumors specifically AKT2 as the predominant isoform involved. In parallel, we assessed several human melanoma biopsy samples and found again that AKT2 was the predominantly activated AKT in these human melanoma biopsies. In c...
Source: Pigment Cell Research - November 9, 2009 Category: Cytology Authors: Seung-Shick Shin, Brian A. Wall, James S. Goydos, Suzie Chen Source Type: journals

FEZ1/LZTS1 protein expression in ovarian cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the reduction or loss of FEZ1 protein could be an aid to the clinical management of patients affected by ovarian carcinoma. J. Cell. Physiol. © 2009 Wiley-Liss, Inc. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - November 2, 2009 Category: Cytology Authors: Daniela Califano, Sandro Pignata, Carmela Pisano, Stefano Greggi, Giuseppe Laurelli, Nunzia Simona Losito, Alessandro Ottaiano, Adolfo Gallipoli, Rosa Pasquinelli, Veronica De Simone, Roberto Cirombella, Alfredo Fusco, Gennaro Chiappetta Source Type: journals

POU6F1 is the transcription factor that might be involved in cell proliferation of clear cell adenocarcinoma of the ovaryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clear cell adenocarcinoma of the ovary often shows resistance to anticancer agents. We investigated new molecules to use when developing molecular-targeting therapy for clear cell adenocarcinoma of the ovary. RMG-I cells without invasive potential and RMG-V cells with invasive potential (derived from clear cell adenocarcinoma of the ovary) were subjected to complementary deoxyribonucleic acid microarray analysis. Caveolin-1, a molecule involved in cellular motility and invasion, showed differing expression between the two cell lines. An RNA interference experiment using the published siRNA for caveolin-1 was carried out. T...
Source: Human Cell - October 26, 2009 Category: Cytology Authors: Norihito YOSHIOKA, Nao SUZUKI, Atsushi UEKAWA, Kazushige KIGUCHI, Bunpei ISHIZUKA Tags: Research Articles Source Type: journals

Epidermal growth factor increases lysophosphatidic acid production in human ovarian cancer cells: roles for phospholipase d2 and receptor transactivation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study explores the role of phospholipase D2 (PLD2) activation in LPA production, as well as cross-talk between EGF and LPA receptors. We demonstrate that EGF and LPA both stimulate production of LPA by OVCAR3 and SKOV3 human ovarian cancer cell lines. PD158780, an EGFR-selective tyrosine kinase inhibitor, blocks LPA production in response to both EGF and LPA in OVCAR3 and SKOV3 cells. Pertussis toxin, an inhibitor of LPA receptor signaling, inhibits LPA production in response to both EGF and LPA. Similar results were observed for the LPA receptor antagonist, Ki16425. Over-expression of PLD2 increases LPA production, w...
Source: American Journal of Physiology. Cell Physiology - October 28, 2009 Category: Cytology Authors: Snider AJ, Zhang Z, Xie Y, Meier KE Tags: Am J Physiol Cell Physiol Source Type: journals

TYRO3-mediated regulation of MITF: a novel target in melanoma?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Pigment Cell Research)
Source: Pigment Cell Research - October 30, 2009 Category: Cytology Authors: Udo Rudloff, Yardena Samuels Source Type: journals

MiR-15a and MiR-16 Control Bmi-1 Expression in Ovarian Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we identify two miRNAs, miR-15a and miR-16, that are underexpressed in ovarian cell lines and in primary ovarian tissues. We show that these miRNAs directly target the Bmi-1 3' untranslated region and significantly correlate with Bmi-1 protein levels in ovarian cancer patients and cell lines. Furthermore, Bmi-1 protein levels are downregulated in response to miR-15a or miR-16 expression and lead to significant reduction in ovarian cancer cell proliferation and clonal growth. These findings suggest the development of therapeutic strategies by restoring miR-15a and miR-16 expression in ovarian cancer and in o...
Source: Cell Research - November 10, 2009 Category: Cytology Authors: Bhattacharya R, Nicoloso M, Arvizo R, Wang E, Cortez A, Rossi S, Calin GA, Mukherjee P Tags: Cancer Res Source Type: journals