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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 31.

Prior abdominal open surgery does not impair outcomes of laparoscopic colorectal surgery: a case–control study in 367 patients
Conclusion This large case–control study suggests that PAOS does not affect postoperative outcomes. For this reason, a systematic laparoscopic approach in patients with PAOS, even with midline incision, should be considered in colorectal surgery.
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: L. Maggiori, M. C. Cook, F. Bretagnol, M. Ferron, A. Alves, Y. Panis Tags: Original article Source Type: research

Does the incidence of unexpected malignancy in ‘benign’ rectal neoplasms undergoing trans‐anal endoscopic microsurgery vary according to lesion morphology?
Conclusion In this study exophytic polyps were less likely to be accurately classified as benign using preoperative ultrasonography/endoscopy when compared with flat‐sessile or mixed morphology polyps.
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: I. Dash, C. J. Walter, J. M. D. Wheeler, N. R. Borley Tags: Original article Source Type: research

Management and short‐term outcome of malignant colorectal polyps in the north of England1
Conclusion Endoscopic management of a subgroup of MCPs appears safe. A clear resection margin (> 0 mm) appears sufficient to avoid surgery, except in locally advanced lesions (Kikuchi 3/Haggitt 4) which have a greater risk of residual cancer at surgery and lymph node metastasis.
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: M. D. Gill, M. D. Rutter, S. J. Holtham Tags: Original article Source Type: research

Comparison of long‐term survival outcome of operative vs nonoperative management of recurrent rectal cancer
Conclusion Most recurrences occur within 5 years of primary surgery, although some occur up to 10 years later. R0 resection is the treatment of choice. There was no survival benefit of R2 resection over nonresected recurrences.
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: A. Bhangu, S. M. Ali, D. Cunningham, G. Brown, P. Tekkis Tags: Original article Source Type: research

Surgery for recurrent rectal cancer: higher and wider?
Conclusion Awareness of the surgical options and a willingness to consider more aggressive options may result in more patients being considered for potentially curative resection.
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: D. P. Harji, B. Griffiths, D. R. McArthur, P. M. Sagar Tags: Systematic review Source Type: research

Incidence of prostate, breast, lung and colorectal cancer following new consultation for musculoskeletal pain: A cohort study among UK primary care patients
The objective was to investigate associations between pain sites and specific cancers, and investigate the hypothesis that musculoskeletal pain is an early marker, rather than cause, of cancer. This was a cohort study in the General Practice Research Database. From a cohort of 46,656 people aged ≥50 years with a recorded musculoskeletal problem in 1996 but not during the previous 2 years, patients with a new consultation for back, neck, shoulder or hip pain in 1996 were selected and compared with 39,253 persons who had had no musculoskeletal consultation between 1994‐1996. Outcome was incidence of prostate, breast, lun...
Source: International Journal of Cancer - January 25, 2013 Category: Cancer & Oncology Authors: Kelvin P Jordan, Richard A Hayward, Milisa Blagojevic‐Bucknall, Peter Croft Tags: Epidemiology Source Type: research

Fatherhood status and risk of prostate cancer. Nationwide, population‐based case‐control study
Abstract Previous studies have shown a decreased risk of prostate cancer for childless men but the cause of the association remains to be elucidated. The aim of this study was to assess risk of prostate cancer by fatherhood status, also considering potential confounding factors. In a case‐control study in Prostate Cancer data Base Sweden (PCBaSe) 2.0, a nationwide, population‐based cohort, data on number of children, marital status, education, comorbidity, and tumor characteristics obtained through nationwide health care registers and demographic databases for 117 328 prostate cancer cases and 562 644 controls, matched...
Source: International Journal of Cancer - January 25, 2013 Category: Cancer & Oncology Authors: Sara M Wirén, Linda I Drevin, Sigrid V Carlsson, Olof Akre, Erik C Holmberg, David E Robinson, Hans G Garmo, Pär E Stattin Tags: Epidemiology Source Type: research

Presence or absence of a positive pathological margin outperforms any other margin‐associated variable in predicting clinically relevant biochemical recurrence in Gleason 7 prostate cancer
Conclusions In Gleason 7 prostate cancer, positive pathological margin status was the only consistent margin‐derived variable determining biochemical failure. The presence of high‐grade disease at the margin may also have an impact on the development of clinically significant biochemical recurrence.
Source: BJU International - January 25, 2013 Category: Urology & Nephrology Authors: James G. Huang, John Pedersen, Matthew K.H. Hong, Laurence M. Harewood, Justin Peters, Anthony J. Costello, Chris M. Hovens, Niall M. Corcoran Tags: Urological Oncology Source Type: research

Androgen deprivation therapy: evidence‐based management of side effects
Conclusion Despite significant improvement in management strategies for the side effects of ADT, the best way of preventing side effects is to use ADT only when it is absolutely indicated.
Source: BJU International - January 25, 2013 Category: Urology & Nephrology Authors: Hamed Ahmadi, Siamak Daneshmand Tags: Urological Oncology Source Type: research

Adverse postoperative outcomes in surgical patients with immune thrombocytopenia
Conclusion:Patients with ITP undergoing surgery are at increased risk of adverse perioperative events, particularly if blood or blood product transfusion are required preoperatively, or the procedure is done as an emergency. Copyright © 2013 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Source: British Journal of Surgery - January 25, 2013 Category: Surgery Authors: C. C. Chang, H. C. Chang, C. H. Wu, C. Y. Chang, C. C. Liao, T. L. Chen Tags: Original Article Source Type: research

Systematic review and meta‐analysis of laparoscopic versus open colectomy with end ileostomy for non‐toxic colitis
Conclusion:Where the procedure can be completed laparoscopically, there may be short‐term benefits over open colectomy for colitis. These results cannot be generalized to critically ill patients in need of an emergency subtotal colectomy. Copyright © 2013 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Source: British Journal of Surgery - January 25, 2013 Category: Surgery Authors: S. A. L. Bartels, T. J. Gardenbroek, D. T. Ubbink, C. J. Buskens, P. J. Tanis, W. A. Bemelman Tags: Systematic review Source Type: research

Social Media and Medical Education: A Brave New World (Mark Ryan MD)
General discussion of social media tools, and examples of how social media can be used to directly enhance medical student teaching. The presentation also describes ways in which social media can be used to teach core competencies, and how social media can be used to enhance professional development. The presentation also discusses some cautions for safe use of social media.
Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded - January 25, 2013 Category: Primary Care Source Type: news

Systematic review of the incidence and prevalence of genital warts
Conclusions: The literature suggests that AGWs are widespread and the prevalence depends on study methodology as suggested by higher rates reported from routine genital examinations versus those from treatment records. However, there remains a need for more population-based studies from certain regions including Africa, Latin America and Southern Asia to further elucidate the global epidemiology of this disease.
Source: BMC Infectious Diseases - January 25, 2013 Category: Infectious Diseases Authors: Harshila PatelMonika WagnerPuneet SinghalSmita Kothari Source Type: research

Specialist clinics for reducing emergency admissions in patients with heart failure: a systematic review and meta-analysis of randomised controlled trials
Conclusions Specialist clinics for patients with heart failure can reduce the risk of unplanned admissions; these were most effective when there was a high intensity of clinic appointments close to the time of discharge which then reduced over the follow-up period.
Source: Heart - January 25, 2013 Category: Cardiology Authors: Thomas, R., Huntley, A., Mann, M., Huws, D., Paranjothy, S., Elwyn, G., Purdy, S. Tags: Reviews Source Type: research

Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a meta-analysis of randomised controlled clinical trials
Conclusion Intracoronary BMC treatment leads to a moderate improvement of LVEF and reduction of LVESV at 6 months that sustained at 12 months follow-up, without a clear significant effect on LVEDV, or infarct size. Furthermore, we found that intracoronary cell therapy is significantly associated with a reduction in recurrent AMI and readmission for heart failure, unstable angina or chest pain.
Source: Heart - January 25, 2013 Category: Cardiology Authors: Delewi, R., Andriessen, A., Tijssen, J. G. P., Zijlstra, F., Piek, J. J., Hirsch, A. Tags: Reviews Source Type: research

Combined use of liquid chromatography triple quadrupole mass spectrometry and liquid chromatography quadrupole time-of-flight mass spectrometry in systematic screening of pesticides and other contaminants in water samples.
Abstract As a suitable way for routine screening of pesticides and control of other organic contaminants in water, the combination of liquid chromatography triple quadrupole tandem mass spectrometry (LC-QqQ-MS/MS) and liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) has been applied to the analysis of 63 surface and waste water samples after conventional solid-phase extraction (SPE). The extracts were screened for 43 pesticides or degradation products by LC-QqQ-MS/MS achieving limits of detection (LOD) ranged from 0.04 to 2ngL(-1). Of the 43 selected pesticides, 33 were detected...
Source: Analytica Chimica Acta - January 24, 2013 Category: Chemistry Authors: Masiá A, Ibáñez M, Blasco C, Sancho JV, Picó Y, Hernández F Tags: Anal Chim Acta Source Type: research

New way to quantify multiple steroidal compounds in wastewater by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry.
Abstract The applicability of comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry to the screening of steroidal compounds in wastewater is demonstrated. Advanced software was utilized to identify unknown compounds in complex two-dimensional chromatograms exploiting retention indices and two different mass spectral databases. Response factors calculated as a function of the individual mass spectra of six commercial standards at different concentrations were used to develop a model allowing the quantitation of all steroidal compounds identified in the sample. The model, base...
Source: Analytica Chimica Acta - January 24, 2013 Category: Chemistry Authors: Kopperi M, Ruiz-Jiménez J, Hukkinen JI, Riekkola ML Tags: Anal Chim Acta Source Type: research

Application of Multivariate Curve Resolution Alternating Least Squares (MCR-ALS) to remote sensing hyperspectral imaging.
Abstract The application of the MCR-ALS method is demonstrated on two simulated remote sensing spectroscopic images and on one experimental reference remote sensing spectroscopic image obtained by the Airborn Visible/Infrared Imaging Spectrometer (AVIRIS). By application of MCR-ALS, the spectra signatures of the pure constituents present in the image and their concentration distribution at a pixel level are estimated. Results obtained by MCR-ALS are compared to those obtained by other methods frequently used in the remote sensing spectroscopic imaging field like VCA and MVSA. In the case of the analysis of the expe...
Source: Analytica Chimica Acta - January 24, 2013 Category: Chemistry Authors: Zhang X, Tauler R Tags: Anal Chim Acta Source Type: research

A Radiologically-Guided Approach to Musculoskeletal Anatomy(Tagliafico et al.)
Source: Springer Medicine titles - January 24, 2013 Category: Databases & Libraries Tags: Diagnostic Radiology Source Type: news

Practical Patch Testing and Chemical Allergens in Contact Dermatitis(Jacob et al.)
Source: Springer Medicine titles - January 24, 2013 Category: Databases & Libraries Tags: Dermatology Source Type: news

Principles and Practice of Interventional Pulmonology
Source: Springer Medicine titles - January 24, 2013 Category: Databases & Libraries Tags: Thoracic Surgery Source Type: news

E-science forum — The Research Lifecycle: Partnering for Success
Librarians and Researchers in an e-science collaboration result in successful research. What do librarians need to know about big data and tools? What can researchers gain from working with librarians? The Research Lifecycle: Partnering for Success (http://nnlm.gov/2013escience/) will explore these questions. You’ll hear the latest on what’s happening with big data from keynote speaker, Victoria Stodden, who has focused on developing standards of openness for data and code sharing, and solving legal and policy barriers. Hear from panelists about tools–eagle-i , VIVO, Data Management Planning Tool, REDCap–...
Source: Midcontinental Region News - January 24, 2013 Category: Databases & Libraries Authors: liaison Tags: All Members Source Type: news

Healthy Campus Initiative takes shape, thanks to innovative UCLA-wide effort
UCLA has launched an integrated, campus-wide effort to promote healthy lifestyle choices and develop best practices that may help other communities seeking to do the same. The UCLA Healthy Campus Initiative, envisioned and supported by philanthropists Jane and Terry Semel, prioritizes the health and wellness of students, staff and faculty. The multi-pronged program is rooted in UCLA's long-term commitment to fostering a culture of mental and physical health and wellness. The Healthy Campus Initiative will support the enhancement and expansion of current health and wellness efforts; offer new and interesting a...
Source: UCLA Newsroom: Health Sciences - January 24, 2013 Category: Universities & Medical Training Source Type: news

New Book by Mayo Clinic and Tufts Medical Center Doctors Help Brain Tumor Patients Steer Their Course
Empowering patients during the course of their treatment is the goal of a new book, Navigating Life with a Brain Tumor, written by neuro-oncologists from Mayo Clinic in Arizona and Tufts Medical Center in Boston.
Source: News from Mayo Clinic - January 24, 2013 Category: Databases & Libraries Authors: Mayo Clinic Source Type: news

Mayo Clinic Named Regional TB Training and Medical Consultation Center
Mayo Clinic has been designated a Regional Tuberculosis Training and Medical Consultation Center by the Centers for Disease Control and Prevention (CDC).
Source: News from Mayo Clinic - January 24, 2013 Category: Databases & Libraries Authors: Mayo Clinic Source Type: news

MEDLINE, PubMed, and PMC (PubMed Central): How are they different?
MEDLINE is the National Library of Medicine journal citation database. Started in the 1960s, it now provides over 20 million references to biomedical and life sciences journal articles back to 1946. MEDLINE includes citations from approximately 5,600 scholarly journals published around the world. PubMed has been available since 1996. Its over 22 million references include the MEDLINE database plus some additional citations. PMC (PubMed Central) launched in 2000 as a free archive for full-text biomedical and life sciences journal articles. PMC serves as a digital counterpart to the NLM extensive print journal collection; it...
Source: NLM General Announcements - January 24, 2013 Category: Databases & Libraries Source Type: news

"Biochim Biophys Acta"; +287 new citations
287 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Biochim Biophys Acta" These pubmed results were generated on 2013/01/24PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.
Source: Biochimica et Biophysica Acta - January 24, 2013 Category: Biochemistry Tags: Report Source Type: research

Activity monitoring in patients with depression: A systematic review
Conclusions: Actigraphy is a potentially valuable source of additional information about patients with depression. However, there are no clear guidelines for use of actigraphy in studies of patients with depression. Further studies should investigate patients treated in the community. Additional work to develop algorithms for differentiating behaviour patterns is also needed.
Source: Journal of Affective Disorders - January 24, 2013 Category: Neurology Authors: Christopher Burton, Brian McKinstry, Aurora Szentagotai Tătar, Antoni Serrano-Blanco, Claudia Pagliari, Maria Wolters Tags: Reviews Source Type: research

Interventions for treating depression in Muslim Patients: A systematic review
Conclusion: Much of the evidence identified by this review is methodologically weak or includes assertions made without qualification. This evidence provides important perspectives, but should be interpreted with caution. High-quality research is needed to improve our understanding of the treatment of depression in Muslim clients, to determine how existing therapies can be modified to meet the needs of Muslim clients, and to evaluate the effectiveness of such modified therapies.
Source: Journal of Affective Disorders - January 24, 2013 Category: Neurology Authors: Sarah Catherine Walpole, Dean McMillan, Allan House, David Cottrell, Ghazala Mir Tags: Reviews Source Type: research

Cardiac Tumor Pathology
series:Current Clinical PathologyCardiac tumors were once a nosographic entity of scarce clinical interest because of the rarity and of the intrinsic diagnostic and therapeutic impossibilities, and were considered a fatal morbid entity. It has now become a topical subject due to advances in clinical imaging (echo, magnetic resonance, computed tomography) as well as innovation in technologies of in-vivo diagnosis. Cardiac ...
Source: Springer Medicine titles - January 24, 2013 Category: Databases & Libraries Tags: Pathology Source Type: news

Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors.
Abstract Phenolnaphthalein derivatives show potential for pharmacological activity as inhibitors of thymidylate synthase (TS) but difficulties in their synthesis and derivatization hinder their development. A deconstruction approach aimed at identifying a suitable new scaffold was proposed. A new scaffold was identified and two compound libraries based on this scaffold were designed. The carboxamide library (Library B) showed specific inhibition activity against Escherichia coli TS, whereas the sulfonamide library (Library C) showed a non-specific inhibition profile against hTS. N-(1,3-Dioxo-1H,3H-benzo[de]isochrom...
Source: Bioorganic and Medicinal Chemistry Letters - January 24, 2013 Category: Chemistry Authors: Ferrari S, Ingrami M, Soragni F, Wade RC, Costi MP Tags: Bioorg Med Chem Lett Source Type: research

The impact of child sexual abuse on the course of bipolar disorder: a systematic review
Conclusions: Child sexual abuse is associated (either directly or indirectly) with some clinical phenomena that represent a more severe form of bipolar disorder. Although such a traumatic experience may directly affect the development of posttraumatic stress disorder, the effects of early sexual abuse on later suicidal behavior, substance abuse, and psychotic symptoms may operate through the mediating influences of certain psychopathological or neurobiological variables.
Source: Bipolar Disorders - January 24, 2013 Category: Psychiatry Authors: Roberto Maniglio Tags: Review Article Source Type: research

Cochrane20 Video Series: new video released
As part of a series of events to mark The Cochrane Collaboration's 20th Anniversary, a series of videos has been commissioned focusing on the ideas, achievements and people that have contributed to the Collaboration's growth since 1993. External link for more information: http://anniversary.cochrane.org/home Contributor's Information Contributor's name: Cochrane Web Team Email address: web@cochrane.org read more
Source: The Cochrane Collaboration - Current news at The Cochrane Collaboration - January 24, 2013 Category: Databases & Libraries Authors: nowens Tags: Authors Centres Current news Cochrane contributors Consumer Network Fields Methods groups Review groups & Events Source Type: news

Flawed forecasting – when science fiction gets it wrong | Jenny Rohn
Forget jetpacks – predicting social change can be a fictional challengeDespite my strong public advocacy of Lab Lit fiction, I have always been a huge science fiction fan too. As a family, we spent the 1970s clustered around the TV watching (the original versions of) Star Trek, Battlestar Galactica, Space: 1999 and many others in the genre. Being taken to see the first Star Wars movie at the age of nine was akin to a religious experience for me.I devoured the genre in print, too. My father subscribed to Fantasy & Science Fiction magazine, which I read cover to cover religiously from about the age of seven until I left ho...
Source: Guardian Unlimited Science - January 24, 2013 Category: Science Authors: Jenny Rohn Tags: Science fiction Blogposts Science fiction and fantasy guardian.co.uk Source Type: news

Synthesis and evaluation of thiazolidinedione and dioxazaborocane analogues as inhibitors of AI-2 quorum sensing in Vibrio harveyi.
Abstract Two focused libraries based on two types of compounds, that is, thiazolidinediones and dioxazaborocanes were designed. Structural resemblances can be found between thiazolidinediones and well-known furanone type quorum sensing (QS) inhibitors such as N-acylaminofuranones, and/or acyl-homoserine lactone signaling molecules, while dioxazaborocanes structurally resemble previously reported oxazaborolidine derivatives which antagonized autoinducer 2 (AI-2) binding to its receptor. Because of this, we hypothesized that these compounds could affect AI-2 QS in Vibrio harveyi. Although all compounds blocked QS, th...
Source: Bioorganic and Medicinal Chemistry - January 24, 2013 Category: Chemistry Authors: Brackman G, Al Quntar AA, Enk CD, Karalic I, Nelis HJ, Van Calenbergh S, Srebnik M, Coenye T Tags: Bioorg Med Chem Source Type: research

Pediatric Hospital Readmission Rates Vary SubstantiallyPediatric Hospital Readmission Rates Vary Substantially
Pediatric readmission rates vary significantly across conditions and hospitals, with an overall rate of unplanned readmissions to acute care hospitals of 6.5%, according to a database study. Medscape Medical News
Source: Medscape Today Headlines - January 24, 2013 Category: Consumer Health News Tags: Pediatrics News Source Type: news

Neoadjuvant therapy for rectal cancer decreases the number of lymph nodes harvested in operative specimens
Conclusions: A decreased lymph node yield in proctectomy specimens from patients treated with NAT is consistent with prior studies. Younger patients had a greater reduction in lymph node harvest after NAT compared with senior patients.
Source: American Journal of Surgery - January 24, 2013 Category: Surgery Authors: Robert Amajoyi, Yoori Lee, Patrick J. Recio, Philip D. Kondylis Tags: Presidential Address Source Type: research

Early-phase technetium-99m sestamibi scintigraphy can improve preoperative localization in primary hyperparathyroidism
Conclusions: A review of early scans in patients with negative imaging increases accurate adenoma localization and allows for minimally invasive operations in more patients.
Source: American Journal of Surgery - January 24, 2013 Category: Surgery Authors: Jocelyn F. Burke, Kalpana Naraharisetty, David F. Schneider, Rebecca S. Sippel, Herbert Chen Tags: Presidential Address Source Type: research

Discharge within 24 to 72 Hours of Colorectal Surgery Is Associated with Low Readmission Rates when Using Enhanced Recovery Pathways
Conclusions: Combining laparoscopy with an ERP optimizes patient care in colorectal surgery. The combination permits early discharge; 38% were discharged within 2 days and 62% within 3 days of surgery, with low readmission rates. These results support that early DoD is possible without compromising patient safety or increasing readmission rates. This might be a marker for low readmission rate, and suggests that readmission rate alone might not be an adequate marker of quality.
Source: Journal of the American College of Surgeons - January 24, 2013 Category: Surgery Authors: Justin K. Lawrence, Deborah S. Keller, Hoda Samia, Bridget Ermlich, Karen M. Brady, Tamar Nobel, Sharon L. Stein, Conor P. Delaney Tags: Original Scientific Articles Source Type: research

Recent trends in resistance to cell envelope–active antibacterial agents among key bacterial pathogens
Cell envelope–active agents, particularly β‐lactams, play a pivotal role in the treatment of bacterial infections and the extent to which their activity is affected by the emergence of multidrug‐resistant organisms is of concern. We analyzed the Surveillance Network (TSN) database to evaluate resistant trends for key cell envelope–active drugs among ESKAPE pathogens. Analysis demonstrated that the activity of these drugs has been notably influenced by the emergence of multidrug resistance; this was especially evident for the β‐lactam drugs. For example, Acinetobacter baumannii resistance to imipenem increased f...
Source: Annals of the New York Academy of Sciences - January 24, 2013 Category: Science Authors: Ronald N. Master, Jennifer Deane, Carol Opiela, Daniel F. Sahm Source Type: research

Correlation between Ki67 and Breast Cancer Prognosis.
Conclusions: The debate on the prognostic role of Ki67 in breast cancer is still open, although most of the studies have established a relation between Ki67 and overall and disease-free survival. Further research should be made in order to establish Ki67 as a standard prognostic marker in breast cancer. PMID: 23364275 [PubMed - as supplied by publisher]
Source: Oncology - January 24, 2013 Category: Cancer & Oncology Authors: Kontzoglou K, Palla V, Karaolanis G, Karaiskos I, Alexiou I, Pateras I, Konstantoudakis K, Stamatakos M Tags: Oncology Source Type: research

HTS by NMR of Combinatorial Libraries: A Fragment-Based Approach to Ligand Discovery.
Abstract Fragment-based ligand design (FBLD) approaches have become more widely used in drug discovery projects from both academia and industry, and are even often preferred to traditional high-throughput screening (HTS) of large collection of compounds (>10(5)). A key advantage of FBLD approaches is that these often rely on robust biophysical methods such as NMR spectroscopy for detection of ligand binding, hence are less prone to artifacts that too often plague the results from HTS campaigns. In this article, we introduce a screening strategy that takes advantage of both the robustness of protein NMR spectrosc...
Source: Chemistry and Biology - January 24, 2013 Category: Chemistry Authors: Wu B, Zhang Z, Noberini R, Barile E, Giulianotti M, Pinilla C, Houghten RA, Pasquale EB, Pellecchia M Tags: Chem Biol Source Type: research

A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells.
We present ML216, a potent inhibitor of the DNA unwinding activity of BLM. ML216 shows cell-based activity and can induce sister chromatid exchanges, enhance the toxicity of aphidicolin, and exert antiproliferative activity in cells expressing BLM, but not those lacking BLM. These data indicate that ML216 shows strong selectivity for BLM in cultured cells. We discuss the potential utility of such a BLM-targeting compound as an anticancer agent. PMID: 23352139 [PubMed - in process]
Source: Chemistry and Biology - January 24, 2013 Category: Chemistry Authors: Nguyen GH, Dexheimer TS, Rosenthal AS, Chu WK, Singh DK, Mosedale G, Bachrati CZ, Schultz L, Sakurai M, Savitsky P, Abu M, McHugh PJ, Bohr VA, Harris CC, Jadhav A, Gileadi O, Maloney DJ, Simeonov A, Hickson ID Tags: Chem Biol Source Type: research

Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Antiretroviral Activity.
Abstract HIV-1 Nef, a critical AIDS progression factor, represents an important target protein for antiretroviral drug discovery. Because Nef lacks intrinsic enzymatic activity, we developed an assay that couples Nef to the activation of Hck, a Src family member and Nef effector protein. Using this assay, we screened a large, diverse chemical library and identified small molecules that block Nef-dependent Hck activity with low micromolar potency. Of these, a diphenylpyrazolo compound demonstrated submicromolar potency in HIV-1 replication assays against a broad range of primary Nef variants. This compound binds di...
Source: Chemistry and Biology - January 24, 2013 Category: Chemistry Authors: Emert-Sedlak LA, Narute P, Shu ST, Poe JA, Shi H, Yanamala N, Alvarado JJ, Lazo JS, Yeh JI, Johnston PA, Smithgall TE Tags: Chem Biol Source Type: research

Heterologous Expression and Engineering Studies of Labyrinthopeptins, Class III Lantibiotics from Actinomadura namibiensis.
This study is detailed investigation on the potential to generate analogs of class III lantibiotics by genetic engineering. PMID: 23352145 [PubMed - in process]
Source: Chemistry and Biology - January 24, 2013 Category: Chemistry Authors: Krawczyk JM, Völler GH, Krawczyk B, Kretz J, Brönstrup M, Süssmuth RD Tags: Chem Biol Source Type: research

Characterization of a Heavy Metal Translocating P-Type ATPase Gene from an Environmental Heavy Metal Resistance Enterobacter sp. Isolate.
Abstract Heavy metals are common contaminants found in polluted areas. We have identified a heavy metal translocating P-type ATPase gene (hmtp) via fosmid library and in vitro transposon mutagenesis from an Enterobacter sp. isolate. This gene is believed to participate in the bacterium's heavy metal resistance traits. The complete gene was identified, cloned, and expressed in a suitable Escherichia coli host cell. E. coli W3110, RW3110 (zntA::Km), GG48 (ΔzitB::Cm zntA::Km), and GG51 (ΔzitB::Cm) were used to study the possible effects of this gene for heavy metal (cadmium and zinc in particular) resistance. Among ...
Source: Applied Biochemistry and Biotechnology - January 24, 2013 Category: Biochemistry Authors: Chien CC, Huang CH, Lin YW Tags: Appl Biochem Biotechnol Source Type: research

VEGF -634G>C polymorphism and diabetic retinopathy risk: A meta-analysis.
CONCLUSION: Our research confirmed the association between the VEGF -634G>C polymorphism and DR in subjects with type 2 diabetes. Well-designed studies with larger sample size and more ethnic groups are required to further validate the results. PMID: 23353010 [PubMed - as supplied by publisher]
Source: Gene - January 24, 2013 Category: Genetics & Stem Cells Authors: Qiu M, Xiong W, Liao H, Li F Tags: Gene Source Type: research

The semantic priming project.
Abstract Speeded naming and lexical decision data for 1,661 target words following related and unrelated primes were collected from 768 subjects across four different universities. These behavioral measures have been integrated with demographic information for each subject and descriptive characteristics for every item. Subjects also completed portions of the Woodcock-Johnson reading battery, three attentional control tasks, and a circadian rhythm measure. These data are available at a user-friendly Internet-based repository ( http://spp.montana.edu ). This Web site includes a search engine d...
Source: Behavior Research Methods - January 24, 2013 Category: Psychiatry & Psychology Authors: Hutchison KA, Balota DA, Neely JH, Cortese MJ, Cohen-Shikora ER, Tse CS, Yap MJ, Bengson JJ, Niemeyer D, Buchanan E Tags: Behav Res Methods Source Type: research

Multicenter Spanish study of spectral‐domain optical coherence tomography in normal children
Conclusions: Normative paediatric SD‐OCT data might facilitate use of SD‐OCT for assessing childhood ophthalmic diseases. This study provides a multicenter paediatric normative database of SD‐OCT peripapillary RNFL and macular data.
Source: Acta Ophthalmologica - January 24, 2013 Category: Opthalmology Authors: Jesús Barrio‐Barrio, Susana Noval, Marta Galdós, Miguel Ruiz‐Canela, Elvira Bonet, María Capote, Maialen Lopez Source Type: research

Federated queries of clinical data repositories: the sum of the parts does not equal the whole.
CONCLUSIONS: Uncertainty in the overlap of patient populations across hospitals limits the effectiveness of SHRINE and other federated query tools. Our technique reduces this uncertainty while retaining an aggregate federated architecture. PMID: 23349080 [PubMed - as supplied by publisher]
Source: Journal of the American Medical Informatics Association - January 24, 2013 Category: Information Technology Authors: Weber GM Tags: J Am Med Inform Assoc Source Type: research