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Prevalence of low back pain in children and adolescents: a meta-analysis
Background: Low back pain (LBP) is common in children and adolescents, and it is becoming a public health concern. In recent years there has been a considerable increase in research studies that examine the prevalence of LBP in this population, but studies exhibit great variability in the prevalence rates reported. The purpose of this research was to examine, by means of a meta-analytic investigation, the prevalence rates of LBP in children and adolescents. Methods: Studies were located from computerized databases (ISI Web of Knowledge, MedLine, PEDro, IME, LILACS, and CINAHL) and other sources. The search period extended ...
Source: BMC Pediatrics - Latest articles - January 26, 2013 Category: Pediatrics Authors: Inmaculada Calvo-MuñozAntonia Gómez-ConesaJulio Sánchez-Meca Source Type: research

Colonic inflammatory myofibroblastic tumours: an institutional review
ConclusionSurgical resection is effective for this rare tumour which mostly behaves in a benign manner. Our review supports the need for patients to be followed up for long periods because of the possibility of metastasis or late recurrence.© 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland
Source: Colorectal Disease - January 26, 2013 Category: Gastroenterology Authors: Gupta Rakesh Kumar, Samalavicius Narimantas Evaldas, Sapkota Sudeep, Sah Panna Lal, Kafle Santosh Upadhyaya Tags: Original Article Source Type: research

The survival of patients with Stage III Colon Cancer is improved in HNPCC compared with sporadic cases. A Danish registry based study
ConclusionHNPCC patients with stage III CC have a better OS compared with sporadic CC. Within HNPCC subgroups, no significant difference in OS was found.© 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland
Source: Colorectal Disease - January 26, 2013 Category: Gastroenterology Authors: Line Merrild Brixen, Inge Thomsen Bernstein, Steffen Bülow, Eva Ehrnrooth Tags: Original Article Source Type: research

Tibia shaft fractures: costly burden of nonunions
Conclusions: Nonunions in TSF's are associated with substantial healthcare resource use, common use of strong opioids, and high per-patient costs. Open fractures are associated with higher likelihood of nonunion. Effective screening of nonunion risk may decrease this morbidity and subsequent healthcare resource use and costs.
Source: BMC Musculoskeletal Disorders - January 26, 2013 Category: Orthopaedics Authors: Evgeniya AntonovaT LeRussel BurgeJohn Mershon Source Type: research

Sulfated small molecules targeting EBV in Burkitt lymphoma: from in silico screening to the evidence of in vitro effect on viral episomal DNA
Abstract EBV infects more than 90% of the world population. Following primary infection, EBV persists in an asymptomatic latent state. Occasionally, it may switch to lytic infection. Latent EBV infection has been associated with several diseases, such as Burkitt lymphoma (BL). To date, there are no available drugs to target latent EBV and the existing broad spectrum antiviral drugs are mainly active against lytic viral infection. Thus, using computational molecular docking, a virtual screen of a library of small molecules, including xanthones and flavonoids (described with potential for antiviral activity against EBV), was...
Source: Chemical Biology and Drug Design - January 26, 2013 Category: Biology Authors: Raquel T. Lima, Hugo Seca, Andreia Palmeira, Miguel X. Fernandes, Felipe Castro, Marta Correia‐da‐Silva, Maria São José Nascimento, Emília Sousa, Madalena Pinto, M. HelenaVasconcelos Tags: Research Article Source Type: research

Agile Health adds Facebook integration to text message-based smoking cessation
Atlanta-based Agile Health, a B2B developer of mobile health interventions, announced a major upgrade to its Kick Buts smoking cessation program. Kick Buts is a text-messaging intervention based on software company HSA Global’s STOMP platform, which was shown in a 2011 randomized trial in the UK to double successful quit rates over a control group. [...]
Source: mobihealthnews - January 25, 2013 Category: Information Technology Authors: Jonah Comstock Tags: Uncategorized Agile Health Cochrane Library GlaxoSmithKline HSA Global Kick Buts Magnus mobile health efficacy smoking cessation text messaging smoking cessation Text2Quit Source Type: news

Announcing MAR Funding Opportunities
We are pleased to announce that MAR funding has been posted for the 2013-2014 contract year.  The application deadline is March 15, 2013 for projects that run May 1, 2013 – April 30, 2014. Funding is a great way to provide health information outreach to a professional or consumer audience, or to pilot a new [...]
Source: NN/LM Middle Atlantic Region Blog - January 25, 2013 Category: Databases & Libraries Authors: mjharvey Tags: @ the RML Consumer Health Disaster / Emergency Preparedness Education Exhibits Funding In the Region Outreach Public Health Technology and Libraries Source Type: news

Emergency Response Guidebook App
The U.S. Department of Transportation Pipeline and Hazardous Materials Safety Administration (PHMSA) 2012 Emergency Response Guidebook provides first responders with a go-to manual to help deal with hazmat accidents during the critical first 30 minutes. It is integrated into the Wireless Information System for Emergency Responders (WISER) to provide on-scene support. PHMSA and the National [...]
Source: NN/LM Middle Atlantic Region Blog - January 25, 2013 Category: Databases & Libraries Authors: mjharvey Tags: Disaster / Emergency Preparedness Public Health Source Type: news

Job Ad: Head, ILL Unit, National Library of Medicine
NLM is recruiting public service leaders with a background in collection access or resource sharing to head our busy ILL Unit (approximately 250,000 transactions annually).  NLM is a lend-only ILL participant.  The majority of our ILL traffic arrives through DOCLINE and we serve as the library of last resort for interlibrary loan in the National [...]
Source: NN/LM Middle Atlantic Region Blog - January 25, 2013 Category: Databases & Libraries Authors: mjharvey Tags: Employment Source Type: news

FDA Info on Metal-on-Metal Hip Implants
On January 18 the U.S. Food and Drug Administration (FDA) issued a Safety Communication on metal-on-metal hip implants. The FDA is providing updated safety information and recommendations to health care providers.  This new information is based on the FDA’s current assessment of metal-on-metal hip implants, including the benefit-risk ratio derived from available data, evaluation of [...]
Source: NN/LM Middle Atlantic Region Blog - January 25, 2013 Category: Databases & Libraries Authors: mjharvey Tags: Public Health Source Type: news

Available Classes Offered from the Midcontinental Region
The NN/LM MCR is happy to announce that registration is now open for two classes from Pat Wagner.  Each will consist of two one-hour online webinars, with "homework" assigned after the first webinar, and results to be reviewed in the second webinar.  MLA CE credit is pending. Both classes are at no-charge and preference for [...]
Source: NN/LM Middle Atlantic Region Blog - January 25, 2013 Category: Databases & Libraries Authors: mjharvey Tags: Education Source Type: news

Data Management in Biomedical Research Presentation
Data Management in Biomedical Research:  Information Challenges and Practical Strategies / co-sponsored by the Harrell Health Sciences Library and the CTSI Who:  Mike Conlon, PhD, Associate Director and COO, CTSI, University of Florida and a panel of experts speaking on national data management trends and challenges When:  March 26, 2013 / Noon – 4 pm [...]
Source: NN/LM Middle Atlantic Region Blog - January 25, 2013 Category: Databases & Libraries Authors: mjharvey Tags: Education In the Region Technology and Libraries Source Type: news

Launch of Open Access Journal on Electronic Clinical Data
The Agency for Healthcare Research and Quality and the Electronic Data Methods Forum are pleased to announce the official launch of eGEMs (Generating Evidence and Methods to improve patient outcomes). eGEMs is an open access journal focused on using electronic clinical data to advance research and quality improvement, with the overall goal of improving patient [...]
Source: NN/LM Middle Atlantic Region Blog - January 25, 2013 Category: Databases & Libraries Authors: mjharvey Tags: Open Access Public Health Source Type: news

Room Still Available for ABCs of DNA Offered at METRO
METRO and the NY-NJ Chapter of the Medical Library Association are co-hosting a 4-hour CE class entitled ABCs of DNA: Unraveling the Mystery of Genetics Information for Consumers.  The class is sponsored by the National Network of Libraries of Medicine, Middle Atlantic Region (NN/LM MAR). Description:  Consumers need access to information and resources about genetic [...]
Source: NN/LM Middle Atlantic Region Blog - January 25, 2013 Category: Databases & Libraries Authors: mjharvey Tags: Education Source Type: news

Nuclear Oncology
Pathophysiology and Clinical ApplicationsNuclear Oncology: Pathophysiology and Clinical Applications is a comprehensive textbook covering the increasing role of radionuclide-based technologies in the management of oncologic patients, with disease-oriented chapters giving a detailed overview of current indications and developments. Topics covered include instrumentation, physics, radiobiology, radioguided surgery, and radionuclide ...
Source: Springer Medicine titles - January 25, 2013 Category: Databases & Libraries Tags: Nuclear Medicine Source Type: news

Systematic review of five feeding routes after pancreatoduodenectomy
Conclusion:There is no evidence to support routine enteral or parenteral feeding after PD. An oral diet may be considered as the preferred routine feeding strategy after PD. Copyright © 2013 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Source: British Journal of Surgery - January 25, 2013 Category: Surgery Authors: A. Gerritsen, M. G. H. Besselink, D. J. Gouma, E. Steenhagen, I. H. M. Borel Rinkes, I. Q. Molenaar Tags: Systematic review Source Type: research

A Literature Review of Findings in Physical Elder Abuse
Conclusion: Two-thirds of injuries that occur in elder abuse are to the upper extremity and maxillofacial region. The social context in which the injuries takes place remains crucial to accurate identification of abuse. This includes a culture of violence in the family; a demented, debilitated, or depressed and socially isolated victim; and a perpetrator profile of mental illness, alcohol or drug abuse, or emotional and/or financial dependence on the victim.Résumé: Objectif: Analyser la littérature médicale à la recherche de descriptions du type de blessures physiques subies dans les cas de violence envers les personn...
Source: Canadian Association of Radiologists Journal - January 25, 2013 Category: Radiology Authors: Kieran Murphy, Sheila Waa, Hussein Jaffer, Agnes Sauter, Amanda Chan Tags: Health Policy and Practice / Santé : politique et pratique médicale Source Type: research

Complications and re-operations after Bristow-Latarjet shoulder stabilization: a systematic review
Conclusion: Osseous stabilization shoulder surgery using original or modified Bristow and Latarjet procedures has a 30% complication rate. Rates of recurrent dislocation and reoperation were 2.9% and 7%, respectively. Mild loss of external rotation is common. Reoperation rates were lower following all-arthroscopic techniques. There was a greater loss of postoperative external rotation with all-arthroscopic surgery.
Source: Journal of Shoulder and Elbow Surgery - January 25, 2013 Category: Orthopaedics Authors: Michael J. Griesser, Joshua D. Harris, Brett W. McCoy, Waqas M. Hussain, Morgan H. Jones, Julie Y. Bishop, Anthony Miniaci Tags: Review Article Source Type: research

Predictors of employment in bipolar disorder: A systematic review
Conclusions are based on a relatively small number of studies and are therefore subject to change with the addition of further studies. A formal meta-regression was not possible due to differences between measures of employment and work functioning.Conclusions: Better assessment and management of depression and cognitive difficulties could improve the occupational functioning of BD patients. There is a need for high quality longitudinal studies specifically designed to investigate predictors of employment in large bipolar disorder samples.
Source: Journal of Affective Disorders - January 25, 2013 Category: Neurology Authors: Eleanor Gilbert, Steven Marwaha Tags: Reviews Source Type: research

Salus in Puerto Rico Joins Mayo Clinic Care Network
Mayo Clinic and Salus officials announced today that Salus, a premier ambulatory health care medical and dental provider in the metropolitan San Juan area, is the first member of the Mayo Clinic Care Network in Puerto Rico and the Caribbean.
Source: News from Mayo Clinic - January 25, 2013 Category: Databases & Libraries Authors: Mayo Clinic Source Type: news

New E-Books Added to AccessMedicine
The Patient History: An Evidence-Based Approach to Differential Diagnosis. 2nd ed. For medical students and others, an accurate differential diagnosis starts with The Patient History. The ideal companion to major textbooks on the physical examination, this trusted guide is widely acclaimed for its skill-building, and evidence based approach to the medical history. Harrison’s Principles of Internal Medicine: Self-Assessment and Board Review. 18th ed. 1,100 review questions! Based on the content of Harrison’s Principles of Internal Medicine, 18th ed, this powerful study tool is essential for Internal Medicine Boa...
Source: What's New on JEFFLINE - January 25, 2013 Category: Databases & Libraries Authors: lgm002 Tags: All News Clinicians Researchers Students Teaching Faculty Source Type: news

Thomson Reuters Hosts Challenge to Generate Ideas for Expanding the Scientific Discovery Experience on the Web of Knowledge
Source: Thomson Scientific - Press Releases - January 25, 2013 Category: Databases & Libraries Source Type: news

The Royal Institution building should be saved for everyone | Tania Browne
Arguments abound at present over whether the financially troubled Royal Institution's historic premises should be saved. But arguments of elitism overlook the fact that it's open to everyone, says Tania BrowneImagine the uproar if the Church of England announced that they were in debt and putting Canterbury Cathedral up for sale. "It's OK," the Archbishop would say, "we'll still take the Church to the people who need it, it's only a building. We can just move. Maybe somewhere a bit more modern, where the upkeep isn't so pricey. Or maybe just hold services in the pub every couple of weeks? People like pubs … " The kerfuff...
Source: Guardian Unlimited Science - January 25, 2013 Category: Science Authors: Tania Browne Tags: Blogposts Charities guardian.co.uk Science and scepticism Royal Institution Source Type: news

Citation bias favoring statistically significant studies was present in medical research
Conclusion: A citation bias favoring significant results occurs in medical research. As a consequence, treatments may seem more effective to the readers of medical literature than they really are.
Source: Journal of Clinical Epidemiology - January 25, 2013 Category: Epidemiology Authors: Anne-Sophie Jannot, Thomas Agoritsas, Angèle Gayet-Ageron, Thomas V. Perneger Tags: Original Articles Source Type: research

Some improvements are apparent in identifying adverse effects in systematic reviews from 1994 to 2011
Abstract: Objective: An increasing amount of research and guidelines has been published on search methodology and the reporting of search strategies in systematic reviews. This research assessed whether this has lead to any improvements in the reporting and quality of searching in systematic reviews of adverse effects.Study Design and Setting: All records within Cochrane Database of Systematic Reviews and Database of Abstracts of Reviews of Effects were scanned for systematic reviews of adverse effects. Data were then extracted on the methods used for information retrieval in these reviews and a descriptive analysis conduc...
Source: Journal of Clinical Epidemiology - January 25, 2013 Category: Epidemiology Authors: Su Golder, Yoon K. Loke, Liliane Zorzela Tags: Review Articles Source Type: research

Using Preoperative Albumin Levels As a Surrogate Marker for Outcomes After Radical Cystectomy for Bladder Cancer
Objective: To evaluate preoperative albumin levels as a marker for comparing survival outcomes after cystectomy in patients with bladder cancer.Materials and Methods: We performed a retrospective record review using our bladder cancer database of 238 patients from 2004 to 2011. Of these, we included 187 patients with sufficient data for analysis, aged 35 years or older, who survived to undergo cystectomy. Serum albumin levels were routinely checked the day before cystectomy. Overall survival and cancer-specific survival by albumin levels were compared using Kaplan-Meier and Cox proportional hazards regression models. Compl...
Source: Urology - January 25, 2013 Category: Urology & Nephrology Authors: Jack W. Lambert, Matthew Ingham, Bethany Barone Gibbs, Robert W. Given, Raymond S. Lance, Stephen B. Riggs Tags: Oncology Source Type: research

Voice disorders in teachers and their associations with work-related factors: A systematic review.
CONCLUSION: This review shows that teachers report voice disorders more often than non-teachers. Various work-related and individual factors are associated with reported voice disorders. Longitudinal studies are urgently required to get more insight into the development of voice disorders, their work-related determinants, and the consequences of these voice disorders for functioning and work performance among teachers. Learning outcomes: PMID: 23415241 [PubMed - as supplied by publisher]
Source: Journal of Communication Disorders - January 25, 2013 Category: Speech Therapy Authors: Cantor Cutiva LC, Vogel I, Burdorf A Tags: J Commun Disord Source Type: research

Stereotactic Body Radiation Therapy for Curative Treatment of Adrenal Metastases.
This study supports the growing body of literature treating patients with adrenal metastases with SBRT. PMID: 23369155 [PubMed - as supplied by publisher]
Source: Technology in Cancer Research and Treatment - January 25, 2013 Category: Cancer & Oncology Authors: Rudra S, Malik R, Ranck MC, Farrey K, Golden DW, Hasselle MD, Weichselbaum RR, Salama JK Tags: Technol Cancer Res Treat Source Type: research

A novel aminoacid determinant of HIV-1 restriction in the TRIM5α variable 1 region isolated in a random mutagenic screen.
Abstract Human-derived antiretroviral transgenes are of great biomedical interest and are actively pursued. HIV-1 is efficiently inhibited at post-entry, pre-integration replication stages by point mutations in the variable region 1 (v1) of the human restriction factor TRIM5α. Here we use a mutated megaprimer approach to create a mutant library of TRIM5α(Hu) v1 and to isolate a mutation at Gly330 (G330E) that inhibits transduction of an HIV-1 vector as efficiently as the previously described mutants at positions Arg332 and Arg335. As was the case for these other mutations, modification of the local v1 charge towa...
Source: Virus Research - January 25, 2013 Category: Virology Authors: Pham QT, Veillette M, Brandariz-Nuñez A, Pawlica P, Thibert-Lefebvre C, Chandonnet N, Diaz-Griffero F, Berthoux L Tags: Virus Res Source Type: research

Polycyclic Peptide Therapeutics.
Abstract Owing to their excellent binding properties, high stability, and low off-target toxicity, polycyclic peptides are an attractive molecule format for the development of therapeutics. Currently, only a handful of polycyclic peptides are used in the clinic; examples include the antibiotic vancomycin, the anticancer drugs actinomycin D and romidepsin, and the analgesic agent ziconotide. All clinically used polycyclic peptide drugs are derived from natural sources, such as soil bacteria in the case of vancomycin, actinomycin D and romidepsin, or the venom of a fish-hunting coil snail in the case of ziconotid...
Source: ChemMedChem - January 25, 2013 Category: Chemistry Authors: Baeriswyl V, Heinis C Tags: ChemMedChem Source Type: research

Chromosomal Microarray Impacts Clinical Management.
Abstract Chromosomal microarray analysis (CMA) is standard of care, first-tier clinical testing for detection of genomic copy number variation (CNV) among patients with developmental disabilities. Although diagnostic yield is higher than traditional cytogenetic testing, management impact has not been well studied. We surveyed genetic services providers regarding CMA ordering practices and perceptions about reimbursement. Lack of insurance coverage due to perceived lack of clinical utility was cited amongst the most frequent reasons why CMA was not ordered when warranted. We compiled a list of genomic regions where ...
Source: Clinical Genetics - January 25, 2013 Category: Genetics & Stem Cells Authors: Riggs ER, Wain KE, Riethmaier D, Packard BS, Andrew Faucett W, Hoppman N, Thorland EC, Patel VC, Miller DT Tags: Clin Genet Source Type: research

Early development and regression in Rett syndrome.
This study utilised developmental profiling to examine symptom presentation in 14 girls with genetically confirmed Rett Syndrome and whose family was participating in the Australian Rett Syndrome or InterRett database. Regression was mostly characterised by loss of hand and/or communication skills (13/14) except one girl demonstrated slowing of skill development. Social withdrawal and inconsolable crying often developed simultaneously (9/14) with social withdrawal of shorter duration than inconsolable crying. Previously acquired gross motor skills declined in just over half of the sample (8/14), mostly observed as a loss o...
Source: Clinical Genetics - January 25, 2013 Category: Genetics & Stem Cells Authors: Lee JY, Leonard H, Piek JP, Downs J Tags: Clin Genet Source Type: research

The effect of road and environmental characteristics on pedestrian hit-and-run accidents in Ghana.
Abstract The number of pedestrians who have died as a result of being hit by vehicles has increased in recent years, in addition to vehicle passenger deaths. Many pedestrians who were involved in road traffic accident died as a result of the driver leaving the pedestrian who was struck unattended at the scene of the accident. This paper seeks to determine the effect of road and environmental characteristics on pedestrian hit-and-run accidents in Ghana. Using pedestrian accident data extracted from the National Road Traffic Accident Database at the Building and Road Research Institute (BRRI) of the Council for Scien...
Source: Accident; Analysis and Prevention. - January 25, 2013 Category: Occupational Health Authors: Aidoo EN, Amoh-Gyimah R, Ackaah W Tags: Accid Anal Prev Source Type: research

The High Rate of de novo Graft Carcinomas in Renal Transplant Recipients.
Conclusion: Thus confirming an increased risk of de novo graft cancer, close monitoring of renal transplant recipients should be discussed with at least an abdominopelvic ultrasonography and PSA measurement once a year. Renal cell graft carcinomas seemed to be mostly small and of papillary type and low grade. PMID: 23363786 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - January 25, 2013 Category: Urology & Nephrology Authors: Viart L, Surga N, Collon S, Jaureguy M, Elalouf V, Tillou X Tags: Am J Nephrol Source Type: research

Variation Exists in Rates of Admission to Intensive Care Units for Heart Failure Patients across Hospitals in the United States.
CONCLUSIONS: ICU admission rates for HF varied markedly across hospitals and lacked association with in-hospital risk-standardized mortality. Greater ICU use correlated with fewer patients receiving ICU interventions. Judicious ICU use could reduce resource consumption without diminishing patient outcomes. PMID: 23355624 [PubMed - as supplied by publisher]
Source: Circulation - January 25, 2013 Category: Cardiology Authors: Safavi KC, Dharmarajan K, Kim N, Strait KM, Li SX, Chen SI, Lagu T, Krumholz HM Tags: Circulation Source Type: research

Association of infant pneumococcal vaccination with pneumococcal pneumonia among mothers: A nested case-control study using the GPRD.
Abstract Since implementation of infant immunization with 7-valent pneumococcal conjugate vaccine (PCV7), increased rates of pneumococcal pneumonia have been reported among adults. Using a cohort of mother-infant pairs identified from the General Practice Research Database in the UK we found that from 2006 to 2010 the annual incidence rate of pneumococcal pneumonia among mothers increased from 61/100,000 to 81/100,000. We identified 43 cases of pneumococcal pneumonia in mothers and 430 control mother-infant pairs. The conditional odds ratio of pneumococcal pneumonia in mothers whose infants received a three-dose se...
Source: Vaccine - January 25, 2013 Category: Allergy & Immunology Authors: Hak E, Shea KM, Jick SS Tags: Vaccine Source Type: research

[Off-label use of drugs in pediatric emergencies : Limitations and grey areas of drug approval.]
[Off-label use of drugs in pediatric emergencies : Limitations and grey areas of drug approval.] Anaesthesist. 2013 Jan 25; Authors: Erker CG, Möllmann M Abstract In the medical treatment of children drugs are frequently used outside the boundaries of the approved licensing and use under the terms of off-label use is possible. However, this requires critical reasoning and experience with the drug involved. With help of a traffic light colored spreadsheet this article illustrates the limitations, problems and possibilities of pharmacotherapy in pediatric emergencies or pediatric anesthesia. Of the 45 emerge...
Source: Der Anaesthesist - January 25, 2013 Category: Anesthesiology Authors: Erker CG, Möllmann M Tags: Anaesthesist Source Type: research

Automatic Identification of Wet and Dry Cough in Pediatric Patients with Respiratory Diseases.
Abstract Cough is the most common symptom of several respiratory diseases. It is a defense mechanism of the body to clear the respiratory tract from foreign materials inhaled accidentally or produced internally by infections. The identification of wet and dry cough is an important clinical finding, aiding in the differential diagnosis especially in children. Wet coughs are more likely to be associated with lower respiratory track bacterial infections. At present during a typical consultation session, the wet/dry decision is based on the subjective judgment of a physician. It is not available for the non-trained per...
Source: Annals of Biomedical Engineering - January 25, 2013 Category: Biomedical Engineering Authors: Swarnkar V, Abeyratne UR, Chang AB, Amrulloh YA, Setyati A, Triasih R Tags: Ann Biomed Eng Source Type: research

Allergic rhinitis and risk of erectile dysfunction – a nationwide population‐based study
ConclusionsPatients with AR appeared to be at higher risk of future ED, possibly in a severity‐dependent manner.
Source: Allergy - January 25, 2013 Category: Allergy & Immunology Authors: V. Y.‐F. Su, C.‐J. Liu, M.‐Y. Lan, Y.‐M. Chen, K.‐C. Su, Y.‐C. Lee, T.‐J. Chen, K.‐T. Chou Tags: Original Article Source Type: research

From Technician to Thinker: Physical Exam Meets Cognitive Reasoning (Deborah R Erlich MD, MMedEd)
Description of pre-clerkship physical diagnosis workshop emphasizing cognitive reasoning as the key to choosing appropriate parts of the physical exam for a specific clinical scenario.
Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded - January 25, 2013 Category: Primary Care Source Type: news

Optimizing Integration of Public Health and Medical Education: The Role of Family Medicine Educators (Jacob Prunuske MD, MSPH)
PowerPoint Presentation from STFM MSE Conference. Includes links to useful resources for Public Health Education, medical student competencies and others.
Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded - January 25, 2013 Category: Primary Care Source Type: news

Affinities of recombinant norovirus P dimers for human blood group antigens
Noroviruses (NoVs), the major cause of viral acute gastroenteritis, recognize histo-blood group antigens (HBGAs) as receptors or attachment factors. To gain a deeper understanding of the interplay between NoVs and their hosts, the affinities of recombinant P dimers (P2's) of a GII.4 NoV (VA387) to a library of 41 soluble analogs of HBGAs were measured using the direct electrospray ionization mass spectrometry assay. The HBGAs contained the A, B, H and Lewis epitopes, with variable sizes (2–6 residues) and different types (1–6). The results reveal that the P2's exhibit a broad specificity for the HBGAs and bind ...
Source: Glycobiology - January 25, 2013 Category: Biology Authors: Han, L., Kitov, P. I., Kitova, E. N., Tan, M., Wang, L., Xia, M., Jiang, X., Klassen, J. S. Tags: ORIGINAL ARTICLES Source Type: research

Evolution of Multisubstrate {beta}-Lactamase Activity [Enzymology]
The extensive use and misuse of antibiotics during the last seven decades has led to the evolution and global spread of a variety of resistance mechanisms in bacteria. Of high medical importance are β-lactamases, a group of enzymes inactivating β-lactam antibiotics. Metallo-β-lactamases (MBLs) are particularly problematic because of their ability to act on virtually all classes of β-lactam antibiotics. An engineered MBL (evMBL9) characterized by low level activity with several β-lactam antibiotics was constructed and employed as a parental MBL in an experiment to examine how an enzyme can evolve toward increased activ...
Source: Journal of Biological Chemistry - January 25, 2013 Category: Chemistry Authors: Sun, S., Zhang, W., Mannervik, B., Andersson, D. I. Tags: Microbiology Source Type: research

Does senescence affect lymph node number and morphology? A systematic review
ConclusionIn this first systematic review to examine changes in lymph nodes with senescence, evidence was accrued to suggest a decline in lymph node number and morphological degeneration in older age groups. These changes might adversely affect immune function and the prognosis of infections and selected cancers in the elderly. Further research is required to confirm these morphological changes and to explore their potential immunological and functional effects.
Source: ANZ Journal of Surgery - January 25, 2013 Category: Surgery Authors: Omid Ahmadi, John L. McCall, Mark D. Stringer Tags: Review Article Source Type: research

Organizing Curiosity Into Realistic Research (William R Phillips MD, MPH)
WORKSHOP ABSTRACT Objectives: New researchers often have difficulty moving from their clinical questions and topical passions to developing studies that are focused, valid and doable. We will explore strategies mentors can use to help them overcome common barriers. Content: This lecture-discussion-workshop aims to help mentors be more effective at helping clinicians and others new to research develop their own ideas into successful studies. We will discuss the common problems encountered by students, residents, fellows and new faculty members in planning and completing original research. We will identify and address the m...
Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded - January 25, 2013 Category: Primary Care Source Type: news

Compliance with clinical practice guidelines for breast cancer treatment: a population-based study of quality-of-care indicators in Italy
Background: It has been documented that variations exist in breast cancer treatment despite wide dissemination of clinical practice guidelines. The aim of this population-based study was to evaluate the impact of regional guidelines (Piedmont guidelines, PGL) for breast cancer diagnosis and treatment on quality-of-care indicators in the Northwestern Italian region of Piedmont. Methods: We included two samples of women aged 50--69 years with incident breast cancer treated in Piedmont before and after the introduction of PGL: 600 in 2002 (pre-PGL) and 621 in 2004 (post-PGL). Patients were randomly selected among all incident...
Source: BMC Health Services Research - January 25, 2013 Category: Journals (General) Authors: Carlotta SacerdoteRita BordonSabina PitarellaMaria ManoIleana BaldiDenise CasellaDaniela CuonzoAlfonso FrigerioLuisella MilanesioFranco MerlettiEva PaganoFulvio RicceriStefano RossoNereo SegnanMariano TomatisGiovannino CicconePaolo VineisAntonio Ponti Source Type: research

Identification of mimotopes of Mycobacterium leprae as potential diagnostic reagents
Conclusions: The preliminary data suggest that may be possible to develop reagents with diagnostic potential based on peptide mimotopes selected by phage display using polyclonal human antibodies.
Source: BMC Infectious Diseases - January 25, 2013 Category: Infectious Diseases Authors: Silvana AlbanJuliana de MouraJoão MinozzoMarcelo MiraVanete Soccol Source Type: research

Prior abdominal open surgery does not impair outcomes of laparoscopic colorectal surgery: a case–control study in 367 patients
Conclusion  This large case–control study suggests that PAOS does not affect postoperative outcomes. For this reason, a systematic laparoscopic approach in patients with PAOS, even with midline incision, should be considered in colorectal surgery.
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: L. Maggiori, M. C. Cook, F. Bretagnol, M. Ferron, A. Alves, Y. Panis Tags: Original article Source Type: research

Does the incidence of unexpected malignancy in ‘benign’ rectal neoplasms undergoing trans‐anal endoscopic microsurgery vary according to lesion morphology?
Conclusion  In this study exophytic polyps were less likely to be accurately classified as benign using preoperative ultrasonography/endoscopy when compared with flat‐sessile or mixed morphology polyps.
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: I. Dash, C. J. Walter, J. M. D. Wheeler, N. R. Borley Tags: Original article Source Type: research

Management and short‐term outcome of malignant colorectal polyps in the north of England1
Conclusion  Endoscopic management of a subgroup of MCPs appears safe. A clear resection margin (> 0 mm) appears sufficient to avoid surgery, except in locally advanced lesions (Kikuchi 3/Haggitt 4) which have a greater risk of residual cancer at surgery and lymph node metastasis.
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: M. D. Gill, M. D. Rutter, S. J. Holtham Tags: Original article Source Type: research