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Physicians Are Talking About: The Culture of Defensive MedicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Just how widespread is defensive medicine? Medscape Family Medicine (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - March 19, 2010 Category: Dermatology Tags: Family Medicine/Primary Care Source Type: info

Stem Cells Used To Model Infant Birth DefectEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hemangiomas -- strawberry-like birthmarks that commonly develop in early infancy -- are generally harmless, but up to 10 percent cause tissue distortion or destruction and sometimes obstruction of vision or breathing. Since the 1960s, problematic hemangiomas have been treated with corticosteroids such as dexamethasone or prednisone... (Source: Dermatology News From Medical News Today)
Source: Dermatology News From Medical News Today - March 19, 2010 Category: Dermatology Tags: Pediatrics / Children's Health Source Type: news

Nonmelanoma Skin Cancer Now Epidemic (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The rate of nonmelanoma skin cancer in the U.S. is reaching epidemic proportions, with more than two million people affected in 2006, researchers said. (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - March 18, 2010 Category: Dermatology Source Type: news

What Is Discoid Eczema (Nummular Dermatitis)? What Causes Discoid Eczema?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discoid eczema, also known as discoid dermatitis, gravitational eczema, nummular dermatitis, and nummular eczema is a form of dermatitis. It is a chronic (long-term) or recurrent condition. A rash appears on the skin in the form of red coin shaped discs - plaques of eczema - which can affect different parts of the body, but primarily the lower legs, hands and forearms, and sometimes the trunk... (Source: Dermatology News From Medical News Today)
Source: Dermatology News From Medical News Today - March 18, 2010 Category: Dermatology Tags: Eczema / Psoriasis Source Type: news

What Is Varicose Eczema (Stasis Dermatitis)? What Causes Varicose Eczema?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Varicose eczema also known as stasis dermatitis, congestion eczema, gravitational dermatitis, gravitational eczema, stasis eczema, is a type of eczema (a chronic skin condition) that affects the legs. It refers to the skin changes that occur in the leg as a result of "stasis" or blood pooling from insufficient venous return... (Source: Dermatology News From Medical News Today)
Source: Dermatology News From Medical News Today - March 18, 2010 Category: Dermatology Tags: Dermatology Source Type: news

Hand Bacteria May One Day Aid Forensic Identification, StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Next time you leave your computer station or close the lid of your laptop think about this: your mouse and keyboard are covered in hand bacteria that could be traced back to you, according to a new US study that suggests the unique bacterial communities we leave behind on objects we have handled may one day sit alongside DNA and fingerprints as part of the forensic tool... (Source: Dermatology News From Medical News Today)
Source: Dermatology News From Medical News Today - March 17, 2010 Category: Dermatology Tags: Biology / Biochemistry Source Type: news

Cancer Articles Tend to Focus on Positive OutcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Cancer Articles Tend to Focus on Positive OutcomesCategory: Health NewsCreated: 3/16/2010 4:10:00 PMLast Editorial Review: 3/17/2010 (Source: MedicineNet Skin General)
Source: MedicineNet Skin General - March 17, 2010 Category: Dermatology Source Type: consumer

Health Tip: Prevent a Fungal Nail InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Health Tip: Prevent a Fungal Nail InfectionCategory: Health NewsCreated: 3/16/2010 10:10:00 AMLast Editorial Review: 3/17/2010 (Source: MedicineNet Skin General)
Source: MedicineNet Skin General - March 17, 2010 Category: Dermatology Source Type: consumer

What Is Hirsutism (Excessive Hairness)? What Causes Hirsitusm?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hirsutism (from the Latin "hirsutus" meaning shaggy, hairy) is a condition of unwanted, male-pattern hair growth in women. It is excessive hairiness on female humans. It may arise from excess male hormones called androgens, the major hormone being testosterone, or it may be due to an ethnic or family trait. The amount of body hair is largely determined by genetic makeup... (Source: Dermatology News From Medical News Today)
Source: Dermatology News From Medical News Today - March 17, 2010 Category: Dermatology Tags: Dermatology Source Type: news

Subungual fixed drug eruptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - March 17, 2010 Category: Dermatology Authors: E. C. Benton, D. McGibbon Source Type: journals

AnnouncementsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 16, 2010 Category: Dermatology Source Type: journals

Six novel ATP2C1 mutations identified in Chinese patients with Hailey–Hailey diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hailey–Hailey disease (HHD) (OMIM 169600), also known as familial benign chronic pemphigus, is a rare autosomal dominantly inherited dermatosis. It is characterized by suprabasal separation (acantholysis) of the epidermis resulting in recurrent blisters, crusted erosions, and warty papules that occur mainly on the body folds, particularly the groin, axillary region, the neck, perianal, and submammary region. Painful erosions in the intertriginous areas may become hypertrophic and malodorous, and even mild disease can affect the quality of life . In occasional cases, the lesions may develop into squamous cell carcinomas ....
Source: Journal of Dermatological Science - March 16, 2010 Category: Dermatology Authors: Hongqing Tian, Xiaoxiao Yan, Hong Liu, Yongxiang Yu, Furen Zhang Tags: Letters to the Editor Source Type: journals

Polymorphisms of FAS and FAS ligand genes and risk of skin cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Skin cancer is the most common form of cancer in the United States among Caucasians. DNA damage induced by ultraviolet (UV) exposure has been shown to be involved in the etiology of melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) . Under normal conditions, UV-induced DNA damage is repaired by DNA repair mechanisms, or cells with damaged DNA undergo apoptosis . Apoptosis can be triggered by one of the two pathways: an intrinsic pathway or an extrinsic pathway. In the extrinsic pathway, a death-ligand binds a death-receptor that is displayed on the cell surface of the damaged cell. FAS ligand (FASL [a...
Source: Journal of Dermatological Science - March 16, 2010 Category: Dermatology Authors: Abrar Qureshi, Hongmei Nan, Michael Dyer, Jiali Han Tags: Letters to the Editor Source Type: journals

Decreased fibroblast contractile activity and reduced fibronectin expression are involved in skin photoagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Skin aging is the result of both intrinsic and extrinsic factors. Extrinsic aging is mainly due to photo-damage caused by ultraviolet (UV) irradiation. A characteristic feature of photo-damaged skin is the deterioration of the dermal connective tissue. On the histological level fragmentation of interstitial collagens is observed which substantially contributes to the reduction of skin's tensile strength . While young dermal fibroblasts exhibit a sufficient capacity to adequately maintain the homeostasis of the extra cellular matrix (ECM), (photo)-aged fibroblasts not only display a decrease of their synthetic activity but ...
Source: Journal of Dermatological Science - March 16, 2010 Category: Dermatology Authors: Anja Knott, Astrid Denckhan, Katja Reuschlein, Ralph Lucius, Olaf Döring, Michael Böttger, Franz Stäb, Horst Wenck, Stefan Gallinat Tags: Letters to the Editor Source Type: journals

Evidence for genetic modifiers other than filaggrin mutations in X-linked ichthyosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
X-linked ichthyosis (XLI) and ichthyosis vulgaris (IV) are the most prevalent skin disorders of cornification in humans and share a similar phenotype of generalized fine scaling of the skin . XLI is due to deletions/mutations in the steroid sulfatase (STS) gene on Xp22.32 . A lack of STS, secreted from lamellar bodies into the interstices of the horny layer, correlates with the preservation of corneodesmosomes and impaired permeability barrier homeostasis . IV is caused by mutations in the filaggrin (FLG) gene on 1q21–23 . The resulting absence/decrease of the precursor protein profilaggrin, the main constituent of the k...
Source: Journal of Dermatological Science - March 16, 2010 Category: Dermatology Authors: Robert Gruber, Andreas R. Janecke, Daniela Grabher, Aileen Sandilands, Christine Fauth, Matthias Schmuth Tags: Letters to the Editor Source Type: journals

Keratinocyte-derived anosmin-1, an extracellular glycoprotein encoded by the X-linked Kallmann syndrome gene, is involved in modulation of epidermal nerve density in atopic dermatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Anosmin-1 produced by epidermal keratinocytes in response to calcium concentrations or cytokines may modulate epidermal nerve density in AD. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 16, 2010 Category: Dermatology Authors: Suhandy Tengara, Mitsutoshi Tominaga, Atsuko Kamo, Kenichi Taneda, Osamu Negi, Hideoki Ogawa, Kenji Takamori Tags: Regular articles Source Type: journals

Spatial and temporal control of laminin-511 and -332 expressions during catagenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results indicated that downregulation of laminin-511 is important for hair regression. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 16, 2010 Category: Dermatology Authors: Chiharu Tateishi, Daisuke Tsuruta, Koji Sugawara, Katsutoshi Yoshizato, Hisayoshi Imanishi, Kazuyo Nishida, Masamitsu Ishii, Hiromi Kobayashi Tags: Regular articles Source Type: journals

Laminin-511, inducer of hair growth, is down-regulated and its suppressor in hair growth, laminin-332 up-regulated in chemotherapy-induced alopeciaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We propose that abrupt hair loss in CIA is, at least in part, caused by down-regulation of laminin-511 and up-regulation of laminin-332 at the transcriptional and translational levels. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 16, 2010 Category: Dermatology Authors: Hisayoshi Imanishi, Daisuke Tsuruta, Chiharu Tateishi, Koji Sugawara, Ralf Paus, Tsutomu Tsuji, Masamitsu Ishii, Kazuo Ikeda, Hiroyuki Kunimoto, Koichi Nakajima, Jonathan C.R. Jones, Hiromi Kobayashi Tags: Regular articles Source Type: journals

Age-related changes of p75 Neurotrophin receptor-positive adipose-derived stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The number of ASCs per unit of tissue weight decreased in aged mice. However, the cells possessed proliferation and differentiation potentials almost equal to those of young mice even though the differentiation potentials showed a tendency of decrease. These results raise the possibility that stem cell functions, self-renewal and multipotency, are maintained regardless of aging. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 16, 2010 Category: Dermatology Authors: Takaaki Yamada, Hirohiko Akamatsu, Seiji Hasegawa, Naoki Yamamoto, Tomohisa Yoshimura, Yuichi Hasebe, Yu Inoue, Hiroshi Mizutani, Tohru Uzawa, Kayoko Matsunaga, Satoru Nakata Tags: Regular articles Source Type: journals

Neutrophil-dominant psoriasis-like skin inflammation induced by epidermal-specific expression of Raf in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Activation of the Raf signaling pathway is involved in the epidermal hyperplasia and the neutrophil-dominant cutaneous inflammatory reactions which are characteristics of psoriasis. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 16, 2010 Category: Dermatology Authors: Masahito Tarutani, Yasutomo Imai, Koubun Yasuda, Hiroko Tsutsui, Kenji Nakanishi, Kiyofumi Yamanishi Tags: Regular articles Source Type: journals

Genistein protects against UVB-induced senescence-like characteristics in human dermal fibroblast by p66Shc down-regulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results indicate that genistein protects UVB-induced senescence-like characteristics in HDFs via maintenance of antioxidant enzyme activities and modulation of mitochondrial oxidative stress through down-regulation of a p66Shc-dependent signaling pathway, which may provide potential prevention against skin aging and even photoaging. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 16, 2010 Category: Dermatology Authors: Yi Na Wang, Wei Wu, Hong Chao Chen, Hong Fang Tags: Regular articles Source Type: journals

Systematic evaluations of skin damage irradiated by an erbium:YAG laser: Histopathologic analysis, proteomic profiles, and cellular responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Both proliferation and apoptosis occurred when the laser-irradiated the skin. (Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 16, 2010 Category: Dermatology Authors: Tai-Long Pan, Pei-Wen Wang, Wan-Ruoh Lee, Chia-Lang Fang, Chih-Chieh Chen, Chun-Ming Huang, Jia-You Fang Tags: Regular articles Source Type: journals

Extrinsic and intrinsic types of atopic dermatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Atopic dermatitis (AD) can be categorized into the extrinsic and intrinsic types. Extrinsic or allergic AD shows high total serum IgE levels and the presence of specific IgE for environmental and food allergens, whereas intrinsic or non-allergic AD exhibits normal total IgE values and the absence of specific IgE. While extrinsic AD is the classical type with high prevalence, the incidence of intrinsic AD is approximately 20% with female predominance. The clinical features of intrinsic AD include relative late onset, milder severity, and Dennie-Morgan folds, but no ichthyosis vulgris or palmar hyperlinearity. The ...
Source: Journal of Dermatological Science - March 16, 2010 Category: Dermatology Authors: Yoshiki Tokura Tags: Invited review article Source Type: journals

Editorial boardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Dermatological Science)
Source: Journal of Dermatological Science - March 16, 2010 Category: Dermatology Source Type: journals

Dermatology CalendarEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Tags: JAAD Online Source Type: journals

Instructions for Category 1 CME CreditEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Tags: Frontmatter Source Type: journals

Information for ReadersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Tags: Frontmatter Source Type: journals

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Tags: Frontmatter Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Tags: Frontmatter Source Type: journals

March iotaderma (#194)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Robert I. Rudolph Tags: JAAD Online Source Type: journals

Iotaderma #195Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Robert I. Rudolph Tags: JAAD Online Source Type: journals

Pantheon der Dermatologie. Herausragende historische PersonlichkeitenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Pantheon in Rome survives today as one of the triumphs of Western architecture. It was erected between 120 and 124 AD by the Emperor Hadrian as a temple dedicated to the multiple gods of Rome. An eighteenth century depiction of it, in masterful perspective, by Giovanni Paolo Panini, now in the National Gallery of Art in Washington, DC graces the cover of this unique tribute to the “deities” of dermatology. It is fittingly entitled Pantheon der Dermatologie. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Robert Goltz Tags: Book Review Source Type: journals

CD34+ connective tissue nevi: Are they unusual?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: A 1-year-old white male with a 6-month history of “raised bumps” overlying the dorsal surface of his neck was brought to our dermatology clinic for evaluation. An agminated patch of white papules was identified on the suboccipital neck (). Nuchal ultrasound was unremarkable. A 3-mm punch biopsy demonstrated spindle cell proliferation within the papillary dermis, without significant atypia (, A). Vascularity was slightly increased. The overlying epidermis was unremarkable. Laboratory tests for Ulex europaeus, S-100, CD68, muscle-specific actin, and smooth muscle actin were negative. The spindle cells and ...
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Kejal R. Shah, Michael J. Wells, Cloyce L. Stetson Tags: Case Letters Source Type: journals

Phenytoin-induced acute generalized exanthemous pustulosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: A 57-year-old African American male with a history of a seizure disorder caused by a traumatic head injury presented to the emergency department with a recent onset of multiple pustular lesions that started on his face and spread to his trunk and upper extremities. He had presented to the same emergency department 5 days earlier in status epilepticus. He was treated with 1 g phenytoin for the first time in addition to increased doses of his other medicines (lorazepam and levetiracetam). His seizure resolved and he was discharged 2 days later on increased doses of levetiracetam and valproic acid. (Source: Jou...
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Nasir Aziz, Samantha Toerge, Thomas Nigra Tags: Case Letters Source Type: journals

Acquired combined nutritional deficiency presenting as psoriasiform dermatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: Nutritional deficiency, a prevalent problem worldwide, remains rare in developed countries. In the United States, acquired nutritional deficiencies have been reported in patients with anorexia nervosa, malabsorption syndromes, those on long-term parenteral nutrition, and patients with food allergies. Given the significant morbidity and sometimes mortality associated with certain nutritional deficiencies, their prompt recognition, diagnosis, and treatment by clinicians is of great importance. Many nutritional deficiencies have classic cutaneous presentations that are valuable clinical diagnostic tools. Howeve...
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Diana Bolotin, Mark I. Racz, Vesna Petronic-Rosic, Aisha Sethi Tags: Case Letters Source Type: journals

Refractory oral ulcers with multiple immunoglobulin G/immunoglobulin A autoantibodies without skin lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: Current molecular diagnostics have characterized many new autoimmune bullous diseases that traditional descriptive dermatology would not have been able to define. Herein we report a case of refractory oral ulcers with immunoblots that were confusing, causing difficulty in making a definitive diagnosis. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Teruki Dainichi, Bungo Ohyama, Norito Ishii, Zenichi Yamaguchi, Shinichiro Yasumoto, Takashi Hashimoto Tags: Case Letters Source Type: journals

Myxoinflammatory fibroblastic sarcoma on the thighEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: Myxoinflammatory fibroblastic sarcoma (MIFS) is a slow growing, low grade tumor reported as a soft tissue tumor affecting the distal extremities. It was first described in 1998 by Meis-Kindblom and Kindblom and Montgomery et al. Although it was described by different names—acral MIFS and inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg–like cells—it described the same entity of histologic features. The reported histologic similarities included numerous inflammatory cells (plasma cells, granulocytes, eosinophils, and lymphocytes), fibrosis, and scattered, large, biza...
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Kim Bui, Sarah Glorioso, Thomas Nicotri, Jeffrey Frederic Tags: Case Letters Source Type: journals

Narrowband ultraviolet B phototherapy influences serum folate levels in patients with vitiligoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: We read with interest the article by Rose et al in the August 2009 issue of the Journal. Ultraviolet B light phototherapy (UVB) is generally considered the safest form of systemic psoriasis therapy in pregnancy. We commend the authors for creating a study to examine the photodegradation of serum folate after exposure to narrowband UVB (nbUVB), given that folate deficiency in the first trimester of pregnancy could predispose to the development of neural tube defects. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Jenny E. Murase, John Y.M. Koo, Timothy G. Berger Tags: Notes & Comments Source Type: journals

Sentinel node biopsy: Not the standard of care for melanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: The International Sentinel Node Society (ISNS) opinion, that sentinel node biopsy (SNB) “is standard of care,” is not supported by clinical evidence and warrants scrutiny. Their commentary contradicts recent multidisciplinary Australian guidelines that state that “Patients with a melanoma greater than 1.0 mm in thickness be given the opportunity to discuss SNB to provide staging and prognostic information” but deliberately do not state that SNB should be considered standard of care. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Michael J. Sladden, Peter Foley, Duncan G. Stanford, Samuel Zagarella, Catherine Reid Tags: Notes & Comments Source Type: journals

The 3S technique: Another minimally invasive technique in the treatment of saphenous varicose veinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: I read with interest the article by Nijsten et al in the January 2009 issue of the Journal that describes three minimally invasive techniques in the treatment of saphenous varicose veins: foam sclerotherapy, endovenous laser therapy, and radiofrequency ablation. Another procedure—the 3S saphenectomy (the 3S technique)—should be added to theses techniques. The 3S technique associates the surgical sectioning and sclerotherapy of saphenous veins under local anesthesia. It has been developed in France mainly by Vin et al. Many angiophlebologists learned this technique during the educational program of the ...
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Sami Abdennader Tags: Notes & Comments Source Type: journals

Hidradenitis suppurativa markedly decreases quality of life and professional activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: We read with great interest the comprehensive review by Alikhan et al in the April 2009 issue of the Journal and would like to comment on our own recent findings regarding hidradenitis suppurativa (HS) and the Dermatology Life Quality Index (DLQI). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Łukasz Matusiak, Andrzej Bieniek, Jacek C. Szepietowski Tags: Notes & Comments Source Type: journals

Concern regarding the safety of tumor necrosis factor-alfa antagonists in pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: Choosing appropriate, safe treatment for pregnant patients with psoriasis can be challenging. Although tumor necrosis factor–alfa (TNFα) antagonists are considered category B drugs according to the US Food and Drug Administration (FDA), Carter et al reported a disturbing association of infliximab and etanercept with congenital anomalies associated with the vertebral, anal, cardiovascular, tracheoesophageal, renal, limb (VACTERL) syndrome. In their review of more than 120000 adverse events of patients on TNFα antagonist therapy, they found 61 congenital anomalies occurring at higher than expected frequenc...
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Andrew Miner Tags: Notes & Comments Source Type: journals

A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein–Barr virus infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report herein a case of EBV-positive LELCS. An 82-year-old female presented with a red nodule on the right cheek. Histologically, the entire dermis was occupied by atypical tumor cell nests with dense lymphocytic infiltration. Neoplastic cells were strongly positive for cytokeratin 14 but were negative for cytokeratins 19 and 20. EBV genomes in neoplastic cells were detected by polymerase chain reaction analysis and in situ hybridization for EBV-encoded RNA, suggesting an association with EBV. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Rui Aoki, Hiroshi Mitsui, Kazutoshi Harada, Tatsuyoshi Kawamura, Naotaka Shibagaki, Katsuhiko Tsukamoto, Shin-ichi Murata, Shinji Shimada Tags: Case Reports Source Type: journals

Coexistent Kaposi sarcoma, cryptococcosis, and Mycobacterium avium intracellulare in a solitary cutaneous nodule in a patient with AIDS: Report of a case and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a report of a 63-year-old man with AIDS who was diagnosed with coexistent Kaposi sarcoma (KS), Cryptococcus neoformans, and Mycobacterium avium intracellulare in a single, solitary lesion. A literature review identified 11 cases of patients with AIDS and cutaneous lesions with co-existent KS and other infectious organisms. To our knowledge, this is the first report of coexistent KS, C neoformans, and M avium intracellulare in the same cutaneous lesion in a patient with AIDS. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Thomas A. Pietras, Christian L. Baum, Brian L. Swick Tags: Case Reports Source Type: journals

Change of AddressEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Tags: Corrections Source Type: journals

ErratumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hossler EW. Caterpillars and moths. Part I. Dermatologic manifestations of encounters with Lepidoptera. J Am Acad Dermatol 2010;62:1-10. Hossler EW. Caterpillars and moths. Part II. Dermatologic manifestations of encounters with Lepidoptera. J Am Acad Dermatol 2010;62:13-28. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Tags: Corrections Source Type: journals

Antioxidants and their chemopreventive properties in dermatologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely topics. Commentaries from Dialogues Editor-in-Chief Jacqueline M. Junkins-Hopkins, MD, are provided after each discussion as a topic summary and are provided here as a special service to readers of the Journal of the American Academy of Dermatology. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Jacqueline M. Junkins-Hopkins Tags: Dialogues in Dermatology Source Type: journals

Pyoderma gangrenosum: A review and update on new therapiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pyoderma gangrenosum is a rare and often painful skin disease that can be unpredictable in its response to treatment. There is currently no gold standard of treatment or published algorithm for choice of therapy. The majority of data comes from case studies that lack a standard protocol not only for treatment administration but also for the objective assessment of lesion response to a specific therapy. This review provides an update to the treatment of pyoderma gangrenosum with a particular focus on new systemic therapies. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Jeremiah Miller, Brad A. Yentzer, Adele Clark, Joseph L. Jorizzo, Steven R. Feldman Tags: Reviews Source Type: journals

Prospective controlled clinical and histopathologic study of hidradenitis suppurativa treated with the long-pulsed neodymium:yttrium-aluminium-garnet laserEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Long-pulsed neodymium:yttrium-aluminium-garnet laser, together with topical benzoyl peroxide and clindamycin, is significantly more effective than topical benzoyl peroxide and clindamycin alone for the treatment of HS. Preliminary review of histopathology suggests the mechanism of action is destruction of the hair follicle. The overall success of the treatment in both clearing pre-existing lesions and preventing new eruptions, coupled with high patient satisfaction, makes the neodymium:yttrium-aluminium-garnet laser a promising treatment advance for this highly disabling condition. (Source: Journal of the Amer...
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Bassel H. Mahmoud, Emily Tierney, Camile L. Hexsel, John Pui, David M. Ozog, Iltefat H. Hamzavi Tags: Dermatologic Surgery Source Type: journals

Midline/paramedian longitudinal matrix excision with flap reconstruction: Alternative surgical techniques for evaluation of longitudinal melanonychiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The different flaps provide elegant local alternatives to second-intention healing and maximize cosmetic and functional results after matrix excision with narrow margins for longitudinal melanonychia. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2010 Category: Dermatology Authors: Siobhan C. Collins, Katharine B. Cordova, Nathaniel J. Jellinek Tags: Dermatologic Surgery Source Type: journals