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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 18.

Response of human chondrocytes and mesenchymal stromal cells to a decellularized human dermis
Conclusions: The results obtained showed that in in vitro conditions HDM_derm behaves as a suitable scaffold for the growth of both well-differentiated chondrocytes and undifferentiated mesenchymal cells, thus ensuring a biocompatible and bioactive substrate. Further studies are mandatory to test the use of HDM_derm with tissue engineering to assess its therapeutic and functional effectiveness in cartilage regeneration.
Source: BMC Musculoskeletal Disorders - January 7, 2013 Category: Orthopaedics Authors: Gianluca GiavaresiElena BondioliDavide MelandriRoberto GiardinoMatilde TschonPaola TorricelliGiovanna CenacchiRoberto RotiniAlessandro CastagnaFrancesca VeronesiStefania PaganiMilena Fini Source Type: research

Cheilitis glandularis: immunohistochemical expression of protein water channels (aquaporins) in minor labial salivary glands
Conclusion Our findings suggest that the expression and arguably, function of some of the AQPs may be altered in CG; consequently, water flow mechanism abnormalities with possible alteration in salivary composition seem to occur. External factors (mainly UV rays) seem to play an important role in CG; nonetheless, our findings suggest that there might be some degree of alteration on water transportation.
Source: Journal of the European Academy of Dermatology and Venereology - January 7, 2013 Category: Dermatology Authors: M.M.S. Nico, J.N. Melo, S.V. Lourenço Tags: SHORT REPORT Source Type: research

Complete filaggrin deficiency in ichthyosis vulgaris is associated with only moderate changes in epidermal permeability barrier function profile
ConclusionsA complete, but not a partial deficiency is associated with moderate changes in TEWL and skin hydration, revealing surprisingly only a mild disturbance of the epidermal permeability barrier function.
Source: Journal of the European Academy of Dermatology and Venereology - January 7, 2013 Category: Dermatology Authors: A.M. Perusquía‐Ortiz, V. Oji, M.C. Sauerland, T. Tarinski, I. Zaraeva, N. Seller, D. Metze, K. Aufenvenne, I. Hausser, H. Traupe Tags: Original Article Source Type: research

Tofacitinib (CP‐690,550), an oral Janus kinase inhibitor, improves patient‐reported outcomes in a phase 2b, randomized, double‐blind, placebo‐controlled study in patients with moderate‐to‐severe psoriasis
ConclusionIn patients with moderate–to–severe chronic plaque psoriasis, short‐term (12–week) treatment with oral twice‐daily tofacitinib improves HRQoL outcomes and patient assessment of disease severity and symptoms, with an early onset noted.
Source: Journal of the European Academy of Dermatology and Venereology - January 7, 2013 Category: Dermatology Authors: C. Mamolo, J. Harness, H. Tan, A. Menter Tags: Original Article Source Type: research

Incidence and risk factors for treatment failure with infliximab in psoriasis
Source: Journal of the European Academy of Dermatology and Venereology - January 7, 2013 Category: Dermatology Authors: H. Escande, C. Bulai Livideanu, A. Steiner, M. Lahfa, M.C. Marguery, J.H. Mazereeuw, N. Meyer, F.G. Labadie, C. Aquilina, R. Viraben, P.A. Gourraud, C. Paul Tags: Letter to the Editor Source Type: research

One Goal, Different Strategies ‐ Molecular and Cellular Approaches for the Treatment of Inherited Skin Fragility Disorders
Abstract Epidermolysis bullosa (EB) is a heterogeneous group of inherited diseases characterized by the formation of blisters in the skin and mucosa. There is no cure or effective treatment for this potentially severe and fatal disease. Over the past few years, several reports have proposed different molecular strategies as new therapeutic options for the management of EB. From classical vector‐based gene therapy to cell‐based strategies such as systemic application of bone marrow stem cells or local application of fibroblasts, a broad range of molecular approaches have been explored. This array also includes novel met...
Source: Experimental Dermatology - January 7, 2013 Category: Dermatology Authors: Christian Hünefeld, Markus Mezger, Johannes S. Kern, Alexander Nyström, Leena Bruckner‐Tuderman, Ingo Müller, Rupert Handgretinger, Martin Röcken Tags: Review Article Source Type: research

Photo protective effect of libanoridin isolated from Corydalis heterocarpa on UVB stressed human keratinocyte (HaCaT) cells
In this study we have investigated the effect of libanoridin isolated from Corydalis heterocarpa against UVB induced damage in human keratinocyte (HaCaT) cells and the molecular mechanism underlying those effects. Treatment with libanoridin inhibited the cell cytotoxicity and LDH induced by UVB exposure at 40 mJ/cm2. Additionally, expression levels of type IV collaganases (MMP‐2, MMP‐9) were decreased by libanoridin. Furthermore, MMP tissue inhibitors were enhanced followed by treatment with libanoridin. Moreover, UVB‐induced activation of phosphorylation of three MAPKs such as JNK, ERK, p38 and AP‐1 transcription ...
Source: Experimental Dermatology - January 7, 2013 Category: Dermatology Authors: Byul‐Nim Ahn, Jung‐Ae Kim, Chang‐Suk Kong, Youngwan Seo, Se‐Kwon Kim Tags: Original Article Source Type: research

Modified Three‐Point Rotation‐Advancement Flap for the Repair of the Melolabial Groove and a Peri‐Alar C‐Shaped Defect
Source: Dermatologic Surgery - January 7, 2013 Category: Dermatology Authors: Byung Cheol Park, Ji Won Gye, Seung Pil Hong, Myung Hwa Kim Tags: Reconstructive Conundrum Source Type: research

Repigmentation of Poliosis After Epithelial Grafting for Vitiligo
ConclusionRe‐coloring of poliosis with vitiligo is possible but was unexpected because of the difference in mechanism and signaling required between hair bulb melanization and the surface skin. One likely mechanism to explain this change is that melanocyte stem cells are stimulated and migrate to supply hair bulbs with new mature melanocytes. Epithelial grafting of vitiligo with poliosis in hairy areas should be a treatment of choice when white hair tufts cause cosmetic disfigurement.
Source: Dermatologic Surgery - January 7, 2013 Category: Dermatology Authors: Sherif S. Awad Tags: Original Article Source Type: research

Optical Coherence Tomography–Based Optimization of Mohs Micrographic Surgery of Basal Cell Carcinoma: A Pilot Study
ConclusionsThe present study shows the prospective utility of using OCT to refine clinically estimated borders for MMS. OCT assessment has the potential to reduce the excised area without compromising the integrity of tumor‐free borders.
Source: Dermatologic Surgery - January 7, 2013 Category: Dermatology Authors: Katie Xiaoyi Wang, Adam Meekings, Joachim W. Fluhr, Gordon McKenzie, David A. Lee, Juliya Fisher, Orit Markowitz, Daniel M. Siegel Tags: Original Article Source Type: research

Safety and Efficacy of Intradermal Injection of Botulinum Toxin for the Treatment of Oily Skin
ConclusionIntradermal injection of botulinum toxin significantly reduced sebum production in the forehead region, with a high degree of patient satisfaction. Intradermal botulinum toxin may be an effective treatment to reduce sebum production in patients with oily skin. Larger, randomized, blinded, placebo‐controlled studies are warranted.
Source: Dermatologic Surgery - January 7, 2013 Category: Dermatology Authors: Amy E. Rose, David J. Goldberg Tags: Original Article Source Type: research

Atypical Cutaneous Leiomyosarcoma with Skip‐Lesion Behavior
Source: Dermatologic Surgery - January 7, 2013 Category: Dermatology Authors: Larry Feigenbaum, Daniel Skinner, Nicholas Golda Tags: Communications and Brief Reports Source Type: research

Quality of Life in Basal Cell Carcinoma Patients in Brazil: A Pilot Cross Sectional Study
ConclusionAge, sex, outdoor activities, habitual sun exposure, or quantity of tumors did not influence quality of life. Patients who had used sunscreen for more than 5 years, had ulcerated tumors, had tumors larger than 2 cm and had tumors located outside of the head had higher DLQI scores.
Source: Dermatologic Surgery - January 7, 2013 Category: Dermatology Authors: Daniel H. Nunes, Tânia S. FrÖde Tags: Original Article Source Type: research

Estimating the Number of Lifetime Follicular Units: A Survey and Comments of Experienced Hair Transplant Surgeons
ConclusionThere are a finite number of FUs containing permanent hairs in any patient. The results of this survey provide a guideline that should be helpful in avoiding inappropriately aggressive goals such as creating overly dense or overly anterior frontal and temporal hairlines without regard for a cautious evaluation of the limitations of likely long‐term donor/recipient area ratios. We present useful guideline numbers that can help physicians choose appropriate surgical goals.
Source: Dermatologic Surgery - January 7, 2013 Category: Dermatology Authors: Walter P. Unger, Robin H. Unger, Carlos K. Wesley Tags: Original Article Source Type: research

Ablative Fractional Resurfacing in Topical Drug Delivery: An Update and Outlook
ConclusionAFR‐assisted drug delivery is a promising tool for the future of dermatology. We expect to see a number of agents to be paired with AFR for enhanced drug delivery. Further investigation is necessary to evaluate appropriate drug specific channel density and depth parameters. Factors that must be considered include the physicochemical properties of the drug, the target tissue, skin wounding, and cost when evaluating the drugs and conditions that will most benefit from this promising new drug delivery system.
Source: Dermatologic Surgery - January 7, 2013 Category: Dermatology Authors: Bradley S. Bloom, Jeremy A. Brauer, Roy G. Geronemus Tags: Review Article Source Type: research

Treatment of Cosmetic Tattoos Using Carbon Dioxide Ablative Fractional Resurfacing in an Animal Model: A Novel Method Confirmed Histopathologically
ConclusionCO2 AFR successfully removes cosmetic tattoos.
Source: Dermatologic Surgery - January 7, 2013 Category: Dermatology Authors: Chia‐Chen Wang, Chuen‐Lin Huang, Yuh‐Mou Sue, Shao‐Chen Lee, Fur‐Jiang Leu Tags: Original Article Source Type: research

Combination of glucosamine improved therapeutic effect of low‐dose cyclosporin A in patients with atopic dermatitis: A pilot study
This study suggests that the C would produce better clinical outcomes than the S regimen in patients with atopic dermatitis, although confirmatory clinical trials are warranted to determine the effect of combination.
Source: The Journal of Dermatology - January 7, 2013 Category: Dermatology Authors: Hyok‐Bu KWON, Byung‐Jin AHN, Yunseok CHOI, Sang Y. JIN, Kyung A. CHEONG, Joongyub LEE, Ai‐Young LEE Tags: Original Article Source Type: research

Atrophic fibrous hamartoma of infancy with epidermal and adnexal changes
Source: The Journal of Dermatology - January 7, 2013 Category: Dermatology Authors: Eishi TAKAHASHI, Hiroo YOKOZEKI, Takahiro SATOH Tags: Letter to the Editor Source Type: research

Rifampicin‐induced lupus erythematosus
Source: The Journal of Dermatology - January 7, 2013 Category: Dermatology Authors: Ting‐Hui LI, Xiao‐Bin HOU, Jian‐Min CHANG Tags: Letter to the Editor Source Type: research

Occupational hand eczema among nursing staffs in Korea: Self‐reported hand eczema and contact sensitization of hospital nursing staffs
Abstract Occupational hand eczema is frequent in hospital workers, especially in nurses. A comprehensive understanding regarding hand eczema is essential for establishing proper prevention and treatment strategies. The purpose of this study was to identify the risk factors for hand eczema in hospital nursing staffs. A self‐administered questionnaire study was performed on hospital nursing staffs at a single general hospital in Korea. In addition, 70 patients with hand eczema underwent patch testing. Five hundred and twenty‐five of 700 invited nurses completed the study (response rate, 75.0%). The overall frequency of s...
Source: The Journal of Dermatology - January 7, 2013 Category: Dermatology Authors: Sang W. LEE, Seung H. CHEONG, Ji Y. BYUN, You W. CHOI, Hae Y. CHOI Tags: Original Article Source Type: research

Protective effect of hochuekkito, a Kampo prescription, against ultraviolet B irradiation‐induced skin damage in hairless mice
Abstract A Kampo prescriptions, hochuekkito (HET) has been utilized for treating functional conditions such as general fatigue, compromised state and gastrointestinal motility disorder. Recently, HET has attracted the attention of dermatologists because of its clinically positive effects in atopic dermatitis (AD) treatment. To explain this positive effect of HET, we examined its protective ability against oxidative skin stress using a murine model. The dorsal region of 8‐week‐old male HR‐1 hairless mice, which were raised on a HET (0%, 2% and 10%) mixed diet, was irradiated once with 70 mJ/cm2 of ultraviolet (UV)‐...
Source: The Journal of Dermatology - January 7, 2013 Category: Dermatology Authors: Shigeto YANAGIHARA, Hiromi KOBAYASHI, Hisashi TAMIYA, Daisuke TSURUTA, Yuri OKANO, Kuniaki TAKAHASHI, Hitoshi MASAKI, Takaaki YAMADA, Seiji HASEGAWA, Hirohiko AKAMATSU, Masamitsu ISHII Tags: Original Article Source Type: research

Epithelioid angiosarcoma of the skin with spontaneous regression
Source: The Journal of Dermatology - January 7, 2013 Category: Dermatology Authors: Aya TANAKA, Atsushi TANEMURA, Chie TSUJI, Ichiro KATAYAMA, Mikio MASUZAWA, Yasuaki NAKASHIMA Tags: Letter to the Editor Source Type: research

Plasmoacanthomas at both angles of mouth treated with carbon dioxide laser ablation
Source: The Journal of Dermatology - January 7, 2013 Category: Dermatology Authors: Hyun Soo ROH, Myeong Gil JEONG, Won Jun CHOI, Mihn Sook JUE, Joo Yeon KO, Young Suck RO Tags: Letter to the Editor Source Type: research

Patient with the vascular type of Ehlers–Danlos syndrome, with a novel point‐mutation in the COL3A1 gene
Source: The Journal of Dermatology - January 7, 2013 Category: Dermatology Authors: Yayoi SHIMAOKA, Shujiro HAYASHI, Yoichiro HAMASAKI, Keita TERUI, Atsushi HATAMOCHI Tags: Letter to the Editor Source Type: research

Clinical predictors in adult‐onset Still disease: There is no getting away from ferritin and arthritis
Source: The Journal of Dermatology - January 7, 2013 Category: Dermatology Authors: Matteo Colina, Francesco Trotta Tags: Letter to the Editor Source Type: research

Daily intake of Jeju groundwater improves the skin condition of the model mouse for human atopic dermatitis
In this study, effects of the natural groundwater from Jeju Island on clinical symptoms and skin barrier function in atopic dermatitis (AD) were evaluated. NC/Tnd mice, a model for human AD, with moderate to severe dermatitis were used. Mice were given different natural groundwater or tap water for 8 weeks from 4 weeks of age. Clinical skin severity scores were recorded every week. Scratching analysis and measurement of transepidermal water loss were performed every other week. The pathological condition of the dorsal skin was evaluated histologically. Real‐time polymerase chain reaction analysis was performed for cyto...
Source: The Journal of Dermatology - January 7, 2013 Category: Dermatology Authors: Akane Tanaka, Kyungsook Jung, Akira Matsuda, Hyosun Jang, Naoki Kajiwara, Yosuke Amagai, Kumiko Oida, Ginnae Ahn, Keitaro Ohmori, Kyung‐goo Kang, Hiroshi Matsuda Tags: Original Article Source Type: research

Identification of a new mutation in TRPS1 gene leading to tricho‐rhino‐phalangeal syndrome I in a Chinese patient
Source: The Journal of Dermatology - January 7, 2013 Category: Dermatology Authors: Shuhua Zhou, Dehui Jin, Yali Song Tags: Letter to the Editor Source Type: research

Identification of a novel heterozygous mutation in the first Japanese case of Marie Unna hereditary hypotrichosis
Source: The Journal of Dermatology - January 7, 2013 Category: Dermatology Authors: Taisuke Ito, Yutaka Shimomura, Masaaki Ogai, Jun‐Ichi Sakabe, Yoshiki Tokura Tags: Letter to the Editor Source Type: research

Case of hypohidrotic ectodermal dysplasia caused by a large deletion mutation in the EDA gene
Source: The Journal of Dermatology - January 7, 2013 Category: Dermatology Authors: Ryota Hayashi, Muhammad Farooq, Hiroki Fujikawa, Atsushi Fujimoto, Tsuyoshi Hashimoto, Masaaki Ito, Yutaka Shimomura Tags: Letter to the Editor Source Type: research

Successful treatment of unresectable dermatofibrosarcoma protuberans on finger with imatinib mesylate and Mohs microsurgery
Source: The Journal of Dermatology - January 7, 2013 Category: Dermatology Authors: In Kyung Jeon, Jong Hoon Kim, Song‐ee Kim, Soo‐Chan Kim, Mi Ryung Roh Tags: Letter to the Editor Source Type: research

Azathioprine‐induced Sweet's syndrome and published work review
This study aims to characterize the clinical findings of azathioprine‐induced SS. A retrospective analysis of the records of three patients diagnosed with azathioprine‐induced SS and a review of the relevant English‐language published work was performed. Twelve (71%) of the 17 patients were male, ranging 9–89 years in age (mean, 47.2). The time of onset after starting azathioprine was 5–28 days (mean, 13.3). The most common associated disease was inflammatory bowel disease including ulcerative colitis and Crohn's disease (76%). The clinical features typically consisted of fever and classic rash of SS with pustu...
Source: The Journal of Dermatology - January 7, 2013 Category: Dermatology Authors: Charoen Choonhakarn, Suteeraporn Chaowattanapanit Tags: Original Article Source Type: research

Unilateral finger tip ulcerations
Source: JDDG - January 7, 2013 Category: Dermatology Authors: Francesco Savoia, Vera Tengattini, Lorenzo Valenti, Giuseppe Gaddoni, Annalisa Patrizi Tags: Case for Diagnosis Source Type: research

PLEVA pemphigoides – synchronous features of PLEVA and bullous pemphigoid
Source: JDDG - January 7, 2013 Category: Dermatology Authors: Stephan Nobbe, Lisa Weibel, Andreas Kuehne, Sharon Gobbi, Katrin Kerl, Antonio Cozzio Tags: Clinical Letters Source Type: research

Association between bullous pemphigoid and internal diseases
Source: JDDG - January 7, 2013 Category: Dermatology Authors: Jun Li, Ya‐Gang Zuo, He‐Yi Zheng, Sun Qiu‐Ning Tags: Scientific Letter Source Type: research

Complementary methods for contact hypersensitivity (CHS) evaluation in mice.
Abstract Contact hypersensitivity (CHS) is an experimental model of allergic contact dermatitis (ACD) that can be studied in mice. For CHS responses, mice are immunized by painting with a reactive hapten, such as 1-fluoro-4,6-dinitrobenzene (DNFB), on the shaved abdominal and chest skin. Subsequently, the ears are challenged with diluted hapten, eliciting 'hypersensitive' ear-swelling reactions, which can be measured with a micrometer. In this manuscript we present complementary methods that can be used to evaluate CHS in mice that include: ear weight, vascular permeability, myeloperoxidase (MPO) activity, IFN-γ c...
Source: Journal of Immunological Methods - January 6, 2013 Category: Allergy & Immunology Authors: Zemelka-Wiącek M, Majewska-Szczepanik M, Pyrczak W, Szczepanik M Tags: J Immunol Methods Source Type: research

A (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano[3,2-g]-chromen-3-yl-ester, attenuates the development of atopic dermatitis-like lesions in NC/Nga mice.
Abstract (S)-(+)-decursin is a biological coumarin compound isolated from Angelica gigas Nakai. (S)-(+)-decursin and its analogue have a variety of pharmacological activities. In the present study, the anti-inflammatory effect of a (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano [3,2-g]-chromen-3-yl-ester (Compound 6, C6), on in vitro and in vivo atopic dermatitis was investigated. C6 suppressed the secretion of IL-6, IL-8, and monocyte chemotactic protein-1 increase by the house dust mite extract in the eosinophilic leukemia cell line and THP-1...
Source: Molecular Biology Reports - January 5, 2013 Category: Molecular Biology Authors: Kim IS, Kim DH, Yun CY, Lee JS Tags: Mol Biol Rep Source Type: research

Epidermolysis bullosa simplex with PLEC mutations: new phenotypes and new mutations.
CONCLUSIONS: Our results confirm that EBS-PA is linked to mutations in the distal exons 1-30 and 32 of PLEC. Long term survival is possible with skin improvement but delayed muscular dystrophy onset is probable. While EBS-MD is linked to PLEC mutations in all exons, in most cases usually one of the mutations affects exon 31. The precocity of muscular dystrophy seems to be linked to type/localization of the PLEC mutation(s) but no correlation with mucosal involvement has been found. PMID: 23289980 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 5, 2013 Category: Dermatology Authors: Charlesworth A, Chiaverini C, Chevrant-Breton J, Delrio M, Diociaiuti A, Dupuis RP, El-Achem M, Le Fiblec B, Sankari-Ho AM, Valhquist A, Wierzbicka E, Lacour JP, Meneguzzi G Tags: Br J Dermatol Source Type: research

Haplotype analysis in Western European patients with Mal de Meleda: founder effect for the W15R mutation in the SLURP1 gene.
Abstract Mal de Meleda, (MDM, OMIM #248300) is an autosomal recessive monogenic disorder defined by progressive transgredient hyperkeratosis of the palms and soles, hyperhidrosis, malodourous scent due to bacterial superinfection, and minor symptoms such as perioral erythema, mild ichthyosis, pseudo-ainhum and nail abnormalities. Mutations in the SLURP1 gene, encoding the Secreted Ly-6/uPar related protein-1, cause Mal de Meleda(1) . SLURP1 enhances the function of the nicotinic acetylcholine receptor α7 (nAChRα7) in epidermal keratinocytes, thereby promoting differentiation of keratinocytes in the stratum granul...
Source: The British Journal of Dermatology - January 5, 2013 Category: Dermatology Authors: Nellen RG, Steijlen PM, Hennies HC, Fischer J, Munro CS, Jonkman MF, van Steensel MA, van Geel M Tags: Br J Dermatol Source Type: research

Pulsed Dye Laser-resistant Port Wine Stains: Mechanisms of Resistance and Implications for Treatment.
Abstract Port wine stains (PWS) are among the most common congenital vascular malformations. Unlike capillary hemangiomas, these lesions do not involute spontaneously but rather become progressively more disfiguring as the patient ages. While benign in nature, the cosmetic deformity and attendant psychological and emotional distress prompt the majority of those afflicted to seek treatment. The pulsed dye laser (PDL) has long been considered the treatment of choice for these vascular lesions; however, very few patients achieve total clearance with PDL therapy and a significant number of lesions fail to respond at al...
Source: The British Journal of Dermatology - January 5, 2013 Category: Dermatology Authors: Savas JA, Ledon JA, Franca K, Chacon A, Nouri K Tags: Br J Dermatol Source Type: research

Analyses of FLG mutation frequency and filaggrin expression in isolated ichthyosis vulgaris and atopic dermatitis associated ichthyosis vulgaris.
CONCLUSIONS: These results indicated that factors other than FLG gene mutations can down-regulate profilaggrin ⁄filaggrin expression, leading to the ichthyosiform phenotype in the context of AD. PMID: 23290076 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 5, 2013 Category: Dermatology Authors: Li M, Cheng R, Shi M, Liu J, Zhang G, Liu Q, Yu H, Yao Z Tags: Br J Dermatol Source Type: research

Epidermolysis bullosa simplex with PLEC mutations: new phenotypes and new mutations
ConclusionsOur results confirm that EBS‐PA is linked to mutations in the distal exons 1‐30 and 32 of PLEC. Long term survival is possible with skin improvement but delayed muscular dystrophy onset is probable. While EBS‐MD is linked to PLEC mutations in all exons, in most cases usually one of the mutations affects exon 31. The precocity of muscular dystrophy seems to be linked to type/localization of the PLEC mutation(s) but no correlation with mucosal involvement has been found.
Source: British Journal of Dermatology - January 5, 2013 Category: Dermatology Authors: A. Charlesworth, C. Chiaverini, J. Chevrant‐Breton, M. DelRio, A. Diociaiuti, R.P. Dupuis, M. El‐Achem, B. Fiblec, A.M. Sankari‐Ho, A. Valhquist, E. Wierzbicka, J.P. Lacour, G. Meneguzzi Tags: Original Article Source Type: research

Haplotype analysis in Western European patients with Mal de Meleda: founder effect for the W15R mutation in the SLURP1 gene
Mal de Meleda, (MDM, OMIM #248300) is an autosomal recessive monogenic disorder defined by progressive transgredient hyperkeratosis of the palms and soles, hyperhidrosis, malodourous scent due to bacterial superinfection, and minor symptoms such as perioral erythema, mild ichthyosis, pseudo‐ainhum and nail abnormalities. Mutations in the SLURP1 gene, encoding the Secreted Ly‐6/uPar related protein‐1, cause Mal de Meleda1. SLURP1 enhances the function of the nicotinic acetylcholine receptor α7 (nAChRα7) in epidermal keratinocytes, thereby promoting differentiation of keratinocytes in the stratum granulosum to the ce...
Source: British Journal of Dermatology - January 5, 2013 Category: Dermatology Authors: R.G.L. Nellen, P.M. Steijlen, H.C. Hennies, J. Fischer, C.S. Munro, M.F. Jonkman, M.A.M. Steensel, M. Geel Tags: Concise Communication Source Type: research

Analyses of FLG mutation frequency and filaggrin expression in isolated ichthyosis vulgaris and atopic dermatitis associated ichthyosis vulgaris
ConclusionsThese results indicated that factors other than FLG gene mutations can down‐regulate profilaggrin ⁄filaggrin expression, leading to the ichthyosiform phenotype in the context of AD.
Source: British Journal of Dermatology - January 5, 2013 Category: Dermatology Authors: M. Li, R. Cheng, M. Shi, J. Liu, G. Zhang, Q. Liu, H. Yu, Z. Yao Tags: Concise Communication Source Type: research

Vesicular form of eosinophilic, polymorphic, and pruritic eruption associated with radiotherapy confined to the irradiated area
Source: The Journal of Dermatology - January 5, 2013 Category: Dermatology Authors: Noriko Shimamoto, Tomoyuki Shirase, Yoshiaki Yoshikawa Tags: Letter to the Editor Source Type: research

Pyodermatitis vegetans associated with multiple myeloma
Source: The Journal of Dermatology - January 5, 2013 Category: Dermatology Authors: Ikko Kajihara, Asako Ichihara, Junko Higo, Masato Kidou, Hironobu Ihn Tags: Letter to the Editor Source Type: research

Late‐onset Darier's disease due to a novel missense mutation in the ATP2A2 gene: A different missense mutation affecting the same codon has been previously reported in acrokeratosis verruciformis
Source: The Journal of Dermatology - January 5, 2013 Category: Dermatology Authors: Daisuke Ueo, Takahiro Hamada, Takashi Hashimoto, Yutaka Hatano, Osamu Okamoto, Sakuhei Fujiwara Tags: Letter to the Editor Source Type: research

Podoplanin expression is inversely correlated with granular layer/filaggrin formation in psoriatic epidermis
Source: The Journal of Dermatology - January 5, 2013 Category: Dermatology Authors: Masaru Honma, Mizue Fujii, Shin Iinuma, Masako Minami‐Hori, Hidetoshi Takahashi, Akemi Ishida‐Yamamoto, Hajime Iizuka Tags: Letter to the Editor Source Type: research

Optic neuritis in a psoriatic arthritis patient treated by infliximab
Source: The Journal of Dermatology - January 5, 2013 Category: Dermatology Authors: Masako Minami‐Hori, Hitomi Tsuji, Hidetoshi Takahashi, Kazuomi Hanada, Hajime Iizuka Tags: Letter to the Editor Source Type: research

Case of Mycoplasma pneumoniae infection with maculopapular‐type eruptions due to acetaminophen
Source: The Journal of Dermatology - January 5, 2013 Category: Dermatology Authors: Naoko Takeo, Yutaka Hatano, Kyoko Yamamoto, Seiji Shiota, Sakuhei Fujiwara Tags: Letter to the Editor Source Type: research

Combined ivermectin and topical therapy significantly reduces treatment time in aged scabietic patients
Source: The Journal of Dermatology - January 5, 2013 Category: Dermatology Authors: Miki Ichikawa, Maya Tanaka, Yuji Naritomi, Masutaka Furue Tags: Letter to the Editor Source Type: research