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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 8.

Fixing the skin barrier: past, present and future - man and dog compared.
Abstract Skin barrier dysfunction exists in both human and canine atopic dermatitis, leading to increased water loss and potentially facilitating allergen penetration and sensitization. Both lipid (e.g. ceramides) and protein (e.g. filaggrin) abnormalities have been described. Some are genetically inherited (e.g. filaggrin mutations are one of the major risk factors in humans) and some are secondary and linked to inflammation. In humans, numerous studies have shown efficacy of emollients and moisturizers in barrier restoration, and this approach has been for years the mainstay of therapy. Recently, this strategy ha...
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Marsella R Tags: Vet Dermatol Source Type: research

Epidermal structure created by canine hair follicle keratinocytes enriched with bulge cells in a three-dimensional skin equivalent model in vitro: implications for regenerative therapy of canine epidermis.
Conclusions and clinical importance - A bulge stem cell-enriched population from canine hair follicles formed interfollicular epidermis within 2 weeks in vitro, and thus represents a promising model for regenerative therapy of canine skin. PMID: 23331683 [PubMed - in process]
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Kobayashi T, Enomoto K, Wang YH, Yoon JS, Okamura R, Ide K, Ohyama M, Nishiyama T, Iwasaki T, Nishifuji K Tags: Vet Dermatol Source Type: research

Skin lipid profiling in normal and seborrhoeic shih tzu dogs.
Conclusions and clinical importance - These results provide evidence that the skin surface lipid profiles are altered in shih tzu dogs with seborrhoea. PMID: 23331684 [PubMed - in process]
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Yoon JS, Nishifuji K, Ishioroshi S, Ide K, Iwasaki T Tags: Vet Dermatol Source Type: research

Stem cell therapy in veterinary dermatology.
Abstract Background - Adult stem cells come from many sources and have the capacity to differentiate into many cell types, including those of the skin. The most commonly studied stem cells are those termed mesenchymal stem cells (MSCs), which are easily isolated from bone marrow and adipose tissue. Mesenchymal stem cells are known to produce a wide array of cytokines that modulate the regeneration process. The ease of collection, propagation and use of these MSCs in therapy of traumatic, ischaemic and immune-mediated skin conditions is emerging. Approach and evidence - In traumatic and ischaemic skin damage, ...
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Harman RJ Tags: Vet Dermatol Source Type: research

A systematic review of randomized controlled trials for prevention or treatment of atopic dermatitis in dogs: 2008-2011 update.
Conclusions and clinical importance - Topical or oral glucocorticoids and oral ciclosporin remain the interventions with highest evidence for efficacy and relative safety for treatment of canine AD. PMID: 23331686 [PubMed - in process]
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Olivry T, Bizikova P Tags: Vet Dermatol Source Type: research

The effect of ketoconazole on whole blood and skin ciclosporin concentrations in dogs.
Conclusions and clinical importance - Administration of CSA and KTZ concurrently at 2.5 mg/kg each may be as effective as CSA alone at 5.0 mg/kg for treatment of canine atopic dermatitis. PMID: 23331687 [PubMed - in process]
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Gray LL, Hillier A, Cole LK, Rajala-Schultz PJ Tags: Vet Dermatol Source Type: research

In vitro antiseptic susceptibilities for Staphylococcus pseudintermedius isolated from canine superficial pyoderma in Japan.
Conclusions and clinical importance - The MICs for chlorhexidine and other antiseptics remain low, and multidrug efflux pump genes were not found in the tested isolates. PMID: 23331688 [PubMed - in process]
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Murayama N, Nagata M, Terada Y, Okuaki M, Takemura N, Nakaminami H, Noguchi N Tags: Vet Dermatol Source Type: research

Photodynamic therapy for pythiosis.
Conclusions and clinical importance - In vitro and in vivo studies showed that PDT was effective in the inactivation of P. insidiosum and may represent a new approach to treating pythiosis. PMID: 23331689 [PubMed - in process]
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Pires L, Bosco Sde M, da Silva Junior NF, Kurachi C Tags: Vet Dermatol Source Type: research

The canine and feline skin microbiome in health and disease.
Abstract The skin harbours a diverse and abundant, yet inadequately investigated, microbial population. The population is believed to play an important role in both the pathophysiology and the prevention of disease, through a variety of poorly explored mechanisms. Early studies of the skin microbiota in dogs and cats reported a minimally diverse microbial composition of low overall abundance, most probably as a reflection of the limitations of testing methodology. Despite these limitations, it was clear that the bacterial population of the skin plays an important role in disease and in changes in response to both i...
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Weese JS Tags: Vet Dermatol Source Type: research

Ulcerated and nonulcerated nontuberculous cutaneous mycobacterial granulomas in cats and dogs.
Abstract Background - Mycobacterial granulomas of the skin and subcutis can be caused by one of a number of pathogens. This review concentrates on noncultivable species that cause diseases characterized by focal granuloma(s), namely leproid granuloma (in dogs) and feline leprosy (in cats). Clinically indistinguishable lesions can be caused by tuberculous organisms (Mycobacterium bovis and Mycobacterium microti) and members of the Mycobacterium avium complex. Rapidly growing mycobacterial species that cause infection of the subcutaneous panniculus associated with draining tracts are not discussed. Disease caused ...
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Malik R, Smits B, Reppas G, Laprie C, O'Brien C, Fyfe J Tags: Vet Dermatol Source Type: research

Prevalence of and risk factors for isolation of meticillin-resistant Staphylococcus spp. from dogs with pyoderma in northern California, USA.
Conclusions and clinical importance - The prevalence of meticillin resistance was not different between VMTH and PCC isolates (P = 0.29). Previous antimicrobial therapy was an important risk factor for the isolation of MRS at both sites. PMID: 23331692 [PubMed - in process]
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Eckholm NG, Outerbridge CA, White SD, Sykes JE Tags: Vet Dermatol Source Type: research

Usefulness of cefovecin disk-diffusion test for predicting mecA gene-containing strains of Staphylococcus pseudintermedius and clinical efficacy of cefovecin in dogs with superficial pyoderma.
Conclusions and clinical importance - The cefovecin disk-diffusion test with a cut-off value estimated in this study was valuable for predicting mecA gene carriage in S. pseudintermedius, as well as the in vivo efficacy of cefovecin therapy in dogs with superficial pyoderma caused by S. pseudintermedius. PMID: 23331693 [PubMed - in process]
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Iyori K, Toyoda Y, Ide K, Iwasaki T, Nishifuji K Tags: Vet Dermatol Source Type: research

Small Demodex populations colonize most parts of the skin of healthy dogs.
Conclusions and clinical importance - Using a real-time PCR technique, Demodex mites, albeit in very low numbers, were found to be normal inhabitants of haired areas of the skin of healthy dogs. PMID: 23331694 [PubMed - in process]
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Ravera I, Altet L, Francino O, Sánchez A, Roldán W, Villanueva S, Bardagí M, Ferrer L Tags: Vet Dermatol Source Type: research

Advances in the management of skin cancer.
Abstract Skin cancer is one of the most commonly diagnosed cancers in the world today in both humans and our pet population. Advances in molecular techniques are now affording us an opportunity to develop therapeutics targeted at specific cancer-related cellular pathways. However, despite progress in conventional treatments, such as chemotherapy and radiation, and the new targeted therapies, some cancers, such as melanoma and cutaneous lymphoma, continue to cause significant mortality and morbidity. This short synopsis is not complete but is aimed at providing an insight into current advanced treatments and horizon...
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Martin PD, Argyle DJ Tags: Vet Dermatol Source Type: research

Kinase dysfunction and kinase inhibitors.
This article reviews the biology of protein kinase dysfunction in human and animal cancers, and the application of specific kinase inhibitors to veterinary cancer patients. PMID: 23331696 [PubMed - in process]
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: London CA Tags: Vet Dermatol Source Type: research

The contribution of stem cells to epidermal and hair follicle tumours in the dog.
Conclusions and clinical importance - Our results show that K15 can be a reliable marker for investigating the role of stem cells in hair follicle tumours of the dog, while nestin was judged to be a nonoptimal marker. Furthermore, our study suggests that hair follicle stem cells are present in the bulge region of hair follicles and could possibly play a role in tumourigenesis of canine tumours originating from this portion of the follicle, namely trichoblastomas, tricholemmomas and trichoepitheliomas. The loss of K15 expression in squamous cell carcinomas compared with normal skin suggests that this event could be impor...
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Brachelente C, Porcellato I, Sforna M, Lepri E, Mechelli L, Bongiovanni L Tags: Vet Dermatol Source Type: research

Epithelial-to-mesenchymal transition: immunohistochemical investigation of related molecules in canine cutaneous epithelial tumours.
Conclusions and clinical importance - A possible simultaneous involvement of survivin and Hsp72 in tumour invasion and the multistep process of EMT of cutaneous epithelial tumours of dogs is suggested. PMID: 23331698 [PubMed - in process]
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Bongiovanni L, D'Andrea A, Romanucci M, Malatesta D, Candolini M, Salda LD, Mechelli L, Sforna M, Brachelente C Tags: Vet Dermatol Source Type: research

Canine inflamed nonepitheliotropic cutaneous T-cell lymphoma: a diagnostic conundrum.
Conclusion - The recognition of inflamed NE-CTCL and its differentiation from cutaneous reactive histiocytosis depends on careful assessment of lymphocyte morphology and immunostaining patterns. Confirmation of the diagnosis is best accomplished by T-cell antigen receptor gene rearrangement analysis. PMID: 23331699 [PubMed - in process]
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Moore PF, Affolter VK, Keller SM Tags: Vet Dermatol Source Type: research

Comparison of hair follicle histology between horses with pituitary pars intermedia dysfunction and excessive hair growth and normal aged horses.
Conclusions - These findings document that excessive hair growth (hypertrichosis) in PPID-affected horses is due to persistence of hair follicles in A. Furthermore, treatment with pergolide improved shedding and reduced the percentage of A follicles in PPID-affected horses. PMID: 23331700 [PubMed - in process]
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Innerå M, Petersen AD, Desjardins DR, Steficek BA, Rosser EJ, Schott HC Tags: Vet Dermatol Source Type: research

Equine sarcoidosis: clinical signs, diagnosis, treatment and outcome of 22 cases.
Conclusions and clinical importance - Recognition of the different forms of sarcoidosis based on history, clinical appearance and histopathology assisted in making an informed choice between treatment and euthanasia and prevented unnecessary local treatment. Equine sarcoidosis should be included in the differential diagnosis of a localized exfoliative dermatitis of unknown origin. PMID: 23331701 [PubMed - in process]
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Sloet van Oldruitenborgh-Oosterbaan MM, Grinwis GC Tags: Vet Dermatol Source Type: research

Turn the Other Cheek
A 56-year-old man underwent two skin biopsies to evaluate facial lesions. The first biopsy was diagnostic for squamous cell carcinoma (SCC); the site was documented as “left cheek” in the health record. The second biopsy was an atrophic solar keratosis (a benign finding); the site was documented as “left inferior orbit.” The primary care physician referred the patient to a dermatologic surgeon. The referral included a diagram of a face with the SCC biopsy site marked by an “X” on the left cheek. The pathology report included a description of the anatomic location that said “left cheek.”
Source: AORN Journal - January 28, 2013 Category: Nursing Tags: Perioperative Grand Rounds Source Type: research

The Pathogenesis and Genetics of Psoriasis.
Abstract Psoriasis vulgaris and psoriatic arthritis are interrelated disorders with an important genetic component. While linkage studies have identified several candidate loci and genes, only recent technological advances and extensive genome-wide association studies have provided robust evidence of associations between psoriasis and several genes inside and outside the major histocompatibility complex. Most of these genes can be incorporated into an integrated pathogenic model of psoriatic disease comprising distinct signaling networks affecting skin barrier function (LCE3, DEFB4, GJB2), innate immune responses i...
Source: Actas Dermo-Sifiliograficas - January 28, 2013 Category: Dermatology Authors: Puig L, Julià A, Marsal S Tags: Actas Dermosifiliogr Source Type: research

Pro-inflammatory cytokines among individuals with skin findings long-term after sulfur mustard exposure: Sardasht-Iran Cohort Study.
This study is part of Sardasht-Iran Cohort Study (SICS) which was performed to compare the serum levels of inflammatory cytokines in SM-exposed individuals (n=372) with long-term relevant skin findings versus unexposed controls (n=128). Serum levels of pro-inflammatory cytokines including IL-1α, IL-1β, IL-1Ra, IL-6, and TNF (tumor necrosis factor) were titrated using ELISA method, 79.9% (n=290) of the exposed group and 60.5% (n=98) of the control group showed skin findings. In the exposed group, 52.1% (n=189) had only skin findings (OSFE) and in the control group, 32% (n=41) had no problem (NC, normal). Median serum leve...
Source: International Immunopharmacology - January 28, 2013 Category: Allergy & Immunology Authors: Moin A, Khamesipour A, Hassan ZM, Ebtekar M, Davoudi SM, Vaez-Mahdavi MR, Soroush MR, Faghihzadeh S, Naghizadeh MM, Ghazanfari T Tags: Int Immunopharmacol Source Type: research

Photosensitivity and photodynamic events in black, red and blue tattoos are common: A ‘Beach Study’
ConclusionComplaints such as swelling, itching, stinging, pain and redness are common, predominantly in black and red tattoos, but also frequent in blue tattoos, thus, not confined to one specific colour or chemical entity or class of pigment. Symptoms may switch on and off in seconds, typically not of the weal‐and‐flare type. Photochemical reactions to pigment or pigment‐breakdown products in situ in the skin with induction of reactive oxygen species (ROS) is presumed to be one causative mechanism. Another possible mechanism especially relevant in black may be induction of ROS due to effects of aggregation of carbon...
Source: Journal of the European Academy of Dermatology and Venereology - January 28, 2013 Category: Dermatology Authors: K. Hutton Carlsen, J. Serup Tags: Original Article Source Type: research

NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials.
CONCLUSIONS: A single 30-minute application of NGX-4010 provides significant pain relief for at least 12 weeks in patients with HIV-DSP and is well tolerated.Trial registration: C107 = NCT00064623; C119 = NCT00321672. PMID: 23351618 [PubMed - as supplied by publisher]
Source: AIDS Research and Therapy - January 28, 2013 Category: Infectious Diseases Authors: Brown S, Simpson DM, Moyle G, Brew BJ, Schifitto G, Larbalestier N, Orkin C, Fisher M, Vanhove GF, Tobias JK Tags: AIDS Res Ther Source Type: research

Keratinocyte Overexpression of IL-17C Promotes Psoriasiform Skin Inflammation.
Abstract IL-17C is a functionally distinct member of the IL-17 family that binds IL-17 receptor E/A to promote innate defense in epithelial cells and regulate Th17 cell differentiation. We demonstrate that IL-17C (not IL-17A) is the most abundant IL-17 isoform in lesional psoriasis skin (1058 versus 8 pg/ml; p < 0.006) and localizes to keratinocytes (KCs), endothelial cells (ECs), and leukocytes. ECs stimulated with IL-17C produce increased TNF-α and KCs stimulated with IL-17C/TNF-α produce similar inflammatory gene response patterns as those elicited by IL-17A/TNF-α, including increases in IL-17C, TNF-α, IL...
Source: Journal of Immunology - January 28, 2013 Category: Allergy & Immunology Authors: Johnston A, Fritz Y, Dawes SM, Diaconu D, Al-Attar PM, Guzman AM, Chen CS, Fu W, Gudjonsson JE, McCormick TS, Ward NL Tags: J Immunol Source Type: research

Alpha2‐antiplasmin regulates the development of dermal fibrosis in mice by prostaglandin F2α synthesis through adipose triglyceride lipase/calcium‐independent phospholipase A2
ConclusionThese findings suggest that α2AP regulates the development of fibrosis by PGF2α synthesis through ATGL/iPLA2. The inhibition of α2AP‐initiated pathways might provide a novel therapeutic approach to fibrotic diseases.
Source: Arthritis and Rheumatism - January 28, 2013 Category: Rheumatology Authors: Yosuke Kanno, Eri Kawashita, Akiko Kokado, Kiyotaka Okada, Shigeru Ueshima, Osamu Matsuo, Hiroyuki Matsuno Tags: Systemic Sclerosis Source Type: research

Tumor necrosis factor–costimulated T lymphocytes from patients with systemic sclerosis trigger collagen production in fibroblasts
ConclusionTNF‐costimulated T lymphocytes from SSc patients have a propensity to secrete profibrotic cytokines, while the ability to produce IL‐10 is weakened. These results suggest that T lymphocytes in SSc support fibrosis, but might lack the capacity to resolve inflammation.
Source: Arthritis and Rheumatism - January 28, 2013 Category: Rheumatology Authors: Thomas Hügle, Steven O'Reilly, Rachel Simpson, Marina D. Kraaij, Venetia Bigley, Matthew Collin, Anja Krippner‐Heidenreich, Jacob M. van Laar Tags: Systemic Sclerosis Source Type: research

Will PAXgene substitute formalin? A morphological and molecular comparative study using a new fixative system
Conclusions The switch from formalin to PAXgene fixation would require a re-evaluation of immunohistochemical markers and staining procedures originally developed for FFPE tissues. Our data demonstrate that PAXPE fixation offers some advantages concerning molecular analysis. However, these advantages would not justify substituting formalin fixation in any routine pathology laboratory.
Source: Journal of Clinical Pathology - January 28, 2013 Category: Pathology Authors: Belloni, B., Lambertini, C., Nuciforo, P., Phillips, J., Bruening, E., Wong, S., Dummer, R. Tags: Skin cancer, Dermatology, Clinical diagnostic tests Original articles Source Type: research

Paraneoplastic pemphigus mimicking toxic epidermal necrolysis associated with B‐cell lymphoma
Source: The Journal of Dermatology - January 28, 2013 Category: Dermatology Authors: Tomoko Yamada, Satoshi Nakamura, Toshio Demitsu, Toshinobu Nakamura, Eri Iida, Kozo Yoneda, Shunpei Fukuda, Takashi Hashimoto Tags: Letter to the Editor Source Type: research

Interferon‐γ promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)‐1 and transforming growth factor (TGF) β2
This study demonstrates distinct effects of IFN‐α and IFN‐γ on the biology of vascular endothelial cells. IFN‐γ may contribute to abnormal vascular remodeling and fibrogenesis in SSc, partially via induction of EndoMT. J. Cell. Physiol. © 2013 Wiley Periodicals, Inc.
Source: Journal of Cellular Physiology - January 28, 2013 Category: Cytology Authors: Izabela Chrobak, Stefania Lenna, Lukasz Stawski, Maria Trojanowska Tags: Original Research Article Source Type: research

NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials
Conclusions: A single 30-minute application of NGX-4010 provides significant pain relief for at least 12 weeks in patients with HIV-DSP and is well tolerated.Trial registration: C107 = NCT00064623; C119 = NCT00321672
Source: AIDS Research and Therapy - January 28, 2013 Category: Infectious Diseases Authors: Stephen BrownDavid SimpsonGraeme MoyleBruce BrewGiovanni SchifittoNicholas LarbalestierChloe OrkinMartin FisherGeertrui VanhoveJeffrey Tobias Source Type: research

Zoledronic acid: Dermatomyositis: case report
Source: Reactions - January 27, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Bendamustine: Flagellate dermatitis with hyperpigmentation: case report
Source: Reactions - January 27, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Electrical impedance spectroscopy as a potential adjunct diagnostic tool for cutaneous melanoma
ConclusionEIS has the potential to be an adjunct diagnostic tool to help clinicians differentiate between benign and malignant (melanocytic and non‐melanocytic) skin lesions. Further studies are needed to confirm the validity of the automatic assessment algorithm.
Source: Skin Research and Technology - January 27, 2013 Category: Dermatology Authors: Peter Mohr, Ulrik Birgersson, Carola Berking, Catriona Henderson, Uwe Trefzer, Lajos Kemeny, Cord Sunderkötter, Thomas Dirschka, Richard Motley, Margareta Frohm‐Nilsson, Uwe Reinhold, Carmen Loquai, Ralph Braun, Filippa Nyberg, John Paoli Tags: Original Article Source Type: research

A comparative study of colour and perfusion between two different post surgical scars. Do the laser Doppler imager and the colorimeter measure the same features of a scar?
ConclusionScars closed with higher mechanical force show higher perfusion and prolonged activity; and more redness is associated with more perfusion for both post surgical scars. Nevertheless, there was no consistent correlation found between these parameters making the laser Doppler imager and the Colorimeter still non‐replaceable instruments.
Source: Skin Research and Technology - January 27, 2013 Category: Dermatology Authors: J. F. Mermans, W. J. Peeters, R. Dikmans, J. Serroyen, R. R. J. W. van der Hulst, E. Van den Kerckhove Tags: Original Article Source Type: research

Old King Coal — molecular mechanisms underlying an ancient treatment for atopic eczema
Traditional remedies for common disorders have been known for centuries, but insight into their mechanism of action is often limited. In this issue of the JCI, Joost Schalkwijk’s research group at the Radboud University Nijmegen Medical Centre in The Netherlands advances our understanding of why topical coal tar is an effective treatment for atopic dermatitis (AD), both rationalizing the use of this traditional medicine, and providing the scientific basis for new therapeutic approaches.
Source: Journal of Clinical Investigation - January 26, 2013 Category: Biomedical Science Authors: W.H. Irwin McLean, Alan D. Irvine Source Type: research

Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis
Topical application of coal tar is one of the oldest therapies for atopic dermatitis (AD), a T helper 2 (Th2) lymphocyte–mediated skin disease associated with loss-of-function mutations in the skin barrier gene, filaggrin (FLG). Despite its longstanding clinical use and efficacy, the molecular mechanism of coal tar therapy is unknown. Using organotypic skin models with primary keratinocytes from AD patients and controls, we found that coal tar activated the aryl hydrocarbon receptor (AHR), resulting in induction of epidermal differentiation. AHR knockdown by siRNA completely abrogated this effect. Coal tar restored ...
Source: Journal of Clinical Investigation - January 26, 2013 Category: Biomedical Science Authors: Ellen H. van den Bogaard, Judith G.M. Bergboer, Mieke Vonk-Bergers, Ivonne M.J.J. van Vlijmen-Willems, Stanleyson V. Hato, Pieter G.M. van der Valk, Jens Michael Schröder, Irma Joosten, Patrick L.J.M. Zeeuwen, Joost Schalkwijk Source Type: research

Nephronectin binds to heparan sulfate proteoglycans via its MAM domain.
Abstract Nephronectin is a basement membrane protein comprising five N-terminal epidermal growth factor (EGF)-like repeats, a central linker segment containing an Arg-Gly-Asp (RGD) motif and a C-terminal meprin-A5 protein-receptor protein tyrosine phosphatase μ (MAM) domain. Nephronectin has been shown to interact with α8β1 integrin through the central linker segment, but its interactions with other molecules remain to be elucidated. Here, we examined the binding of nephronectin to a panel of glycosaminoglycan (GAG) chains. Nephronectin bound strongly to heparin and chondroitin sulfate (CS)-E and moderately to h...
Source: Matrix Biology - January 26, 2013 Category: Molecular Biology Authors: Sato Y, Shimono C, Li S, Nakano I, Norioka N, Sugiura N, Kimata K, Yamada M, Sekiguchi K Tags: Matrix Biol Source Type: research

Dermatan 4-O-sulfotransferase1 ablation accelerates peripheral nerve regeneration.
Abstract Chondroitin sulfate (CS) and dermatan sulfate (DS) proteoglycans are major components of the extracellular matrix implicated in neural development, plasticity and regeneration. While it is accepted that CS are major inhibitors of neural regeneration, the contributions of DS to regeneration have not been assessed. To enable a novel approach in studies on DS versus CS roles during development and regeneration, we generated a mouse deficient in the dermatan 4-O-sulfotransferase1 (Chst14(-/-)), a key enzyme in the synthesis of iduronic acid-containing modules found in DS but not CS. In wild-type mice, Chst14 i...
Source: Experimental Neurology - January 26, 2013 Category: Neurology Authors: Akyüz N, Rost S, Mehanna A, Bian S, Loers G, Oezen I, Mishra B, Hoffmann K, Guseva D, Laczynska E, Irintchev A, Jakovcevski I, Schachner M Tags: Exp Neurol Source Type: research

Immunohistochemical localization of two types of choline acetyltransferase in neurons and sensory cells of the octopus arm.
Abstract Cholinergic structures in the arm of the cephalopod Octopus vulgaris were studied by immunohistochemistry using specific antisera for two types (common and peripheral) of acetylcholine synthetic enzyme choline acetyltransferase (ChAT): antiserum raised against the rat common type ChAT (cChAT), which is cross-reactive with molluscan cChAT, and antiserum raised against the rat peripheral type ChAT (pChAT), which has been used to delineate peripheral cholinergic structures in vertebrates, but not previously in invertebrates. Western blot analysis of octopus extracts revealed a single pChAT-positive band, sugg...
Source: Brain Structure and Function - January 26, 2013 Category: Neuroscience Authors: Sakaue Y, Bellier JP, Kimura S, D'Este L, Takeuchi Y, Kimura H Tags: Brain Struct Funct Source Type: research

[Seminar] Pemphigoid diseases
Pemphigoid diseases are a group of well defined autoimmune disorders that are characterised by autoantibodies against structural proteins of the dermal–epidermal junction and, clinically, by tense blisters and erosions on skin or mucous membranes close to the skin surface. The most common of these diseases is bullous pemphigoid, which mainly affects older people and the reported incidence of which in Europe has more than doubled in the past decade. Prognosis and treatments vary substantially between the different disorders and, since clinical criteria are usually not sufficient, direct immunofluorescence microscopy of a ...
Source: LANCET - January 25, 2013 Category: Journals (General) Authors: Enno Schmidt, Detlef Zillikens Tags: Seminar Source Type: research

Roswell's Niagara clinic comes on line
Roswell Park Cancer Institute has opened its Niagara County satellite location. The Wheatfield site, Roswell Park Niagara, is located on the ground floor of the Summit Healthplex on Williams Road across from the former Summit Park Mall. As previously reported last June in Business First, the site will provide surgical oncologists to see new patients, provide consultations and follow-up care for thoracic, colorectal, urology, neurosurgery. Additionally, a dermatologist will provide services, including…
Source: bizjournals.com Health Care:Physician Practices headlines - January 25, 2013 Category: American Health Authors: Tracey Drury Source Type: research

Cutaneous noradrenaline measured by microdialysis in complex regional pain syndrome during whole-body cooling and heating.
Abstract Complex regional pain syndrome (CRPS) is characterised by autonomic, sensory, and motor disturbances. The underlying mechanisms of the autonomic changes in CPRS are unknown. However, it has been postulated that sympathetic inhibition in the acute phase with locally reduced levels of noradrenaline is followed by an up-regulation of alpha-adrenoceptors in chronic CRPS leading to denervation supersensitivity to catecholamines. This exploratory study examined the effect of cutaneous sympathetic activation and inhibition on cutaneous noradrenaline release, vascular reactivity, and pain in CRPS patients and in h...
Source: Experimental Neurology - January 25, 2013 Category: Neurology Authors: Terkelsen AJ, Gierthmühlen J, Petersen LJ, Knudsen L, Christensen NJ, Kehr J, Yoshitake T, Madsen CS, Wasner G, Baron R, Jensen TS Tags: Exp Neurol Source Type: research

Pemphigus vulgaris in a Welsh pony stallion: case report and demonstration of antidesmoglein autoantibodies.
CONCLUSIONS AND CLINICAL IMPORTANCE: Pemphigus vulgaris is rarely diagnosed in equids. We describe a case that was substantiated by the demonstration of anti-Dsg3 IgG. Response to treatment was poor, with the best response to high doses of prednisolone. Equine pemphigus vulgaris is likely to carry a poor prognosis and if there is no response to treatment, humane euthanasia is warranted. PMID: 23347322 [PubMed - as supplied by publisher]
Source: Veterinary Dermatology - January 25, 2013 Category: Veterinary Research Authors: Winfield LD, White SD, Affolter VK, Renier AC, Dawson D, Olivry T, Outerbridge CA, Wang YH, Iyori K, Nishifuji K Tags: Vet Dermatol Source Type: research

Invited Commentary: Use of Arsenical Skin Lesions to Predict Risk of Internal Cancer--Implications for Prevention and Future Research
Arsenic exposure affects millions of people worldwide, causing substantial mortality and morbidity from cancers and cardiovascular and respiratory diseases. An article in the current issue (Am J Epidemiol. 2013;177(3):202–212) reports that classic dermatological manifestations, typically associated with chronic arsenic exposure, are predictive of internal cancers among Taiwanese decades after the cessation of exposure. Specifically, the risk of lung and urothelial cancers was elevated, which was evident regardless of arsenic dose, smoking, and age. There was also an unexpected elevated risk of prostate cancer. Despit...
Source: American Journal of Epidemiology - January 25, 2013 Category: Epidemiology Authors: Ahsan, H., Steinmaus, C. Tags: RESEARCH-ARTICLE Source Type: research

Infliximab‐associated Blastomycosis dermatitidis in treatment of ulcerative colitis
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: D. A. McCann, H. L. Smith Tags: Case report Source Type: research

Adding Pancreatic Panniculitis to the Panel of Skin Lesions Associated with Triple Therapy of Chronic Hepatitis C
Dermatological side‐effects are a major concern in peginterferon (PegIFN)‐based treatments of hepatitis C virus (HCV) infection, with eczematous dermatitis, xerosis, generalized pruritus, and exacerbation of underlying skin disorders as prominent examples. The recent registration of the protease inhibitor telaprevir in combination with PegIFN and ribavirin (RBV) is expected to significantly increase the rate and severity of dermatological side‐effects by causing a rash in more than 50% of patients. Thus, early recognition of skin abnormalities will be crucial to assure their effective treatment, avoid premature cessa...
Source: Liver International - January 25, 2013 Category: Gastroenterology Authors: Nubio Pfaundler, Kerstin Kessebohm, Roland Blum, Marco Stieger, Felix Stickel Tags: Letter to the Editor Source Type: research

Impaired Notch‐MKP‐1 signalling in hidradenitis suppurativa:An approach to pathogenesis by evidence from translational biology
Abstract Recent findings in familial hidradenitis suppurativa (HS) demonstrated loss‐of‐function mutations of components of the γ‐secretase (GS) complex leading to decreased protease cleaving activity, which may compromise canonical Notch signalling. Appropriate Notch signalling is of pivotal importance for maintaining the inner and outer root sheath of the hair follicle and skin appendages. This viewpoint on the pathogenesis of HS is primarily supported by circumstantial evidence derived from translational biology. Impaired Notch signalling is proposed to be the major pathogenic mechanism of HS. Deficient Notch sig...
Source: Experimental Dermatology - January 25, 2013 Category: Dermatology Authors: Bodo C. Melnik, Gerd Plewig Tags: Viewpoint Source Type: research

“9‐cis Retinoic Acid is the ALDH1A1 Product that Stimulates Melanogenesis”
In this study, a combination of RNAi and pharmacologic approaches were used to determine which ALDH1A1 substrates and products regulate melanogenesis. Initial studies revealed that neither the UV‐induced lipid aldehyde 4‐hydroxy‐2‐nonenal nor the ALDH1A1 product all‐trans retinoic acid appreciably induced melanogenesis. In contrast, both the ALDH1A1 substrate 9‐cis retinal and its corresponding product 9‐cis retinoic acid potently induced the accumulation of MITF mRNA, Tyrosinase mRNA, and melanin. ALDH1A1 depletion inhibited the ability of 9‐cis retinal but not 9‐cis retinoic acid to stimulate melanogene...
Source: Experimental Dermatology - January 25, 2013 Category: Dermatology Authors: Elyse K. Paterson, Hsiang Ho, Rubina Kapadia, Anand K. Ganesan Tags: Regular Article Source Type: research