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Metals in female scalp hair globally and its impact on perceived hair health
Globally, billions of individuals wash their hair in water, which acts as an exogenous metal source. Many studies which measure the metal levels found on human hair specifically aim to remove exogenous materials prior to analysis. While this is needed when using hair analysis to probe the impact of the local environment on endogenous metal levels, it's not relevant for understanding exactly what is on hair as a result of contact with its daily environment. Understanding these levels are important, as the presence of redox active metals, such as copper and iron, can impact fibre health, either due to UV irradiation, or duri...
Source: International Journal of Cosmetic Science - January 11, 2013 Category: Dermatology Authors: Simon Godfrey, William Staite, Phillip Bowtell, Jennifer Marsh Tags: Original Article Source Type: research

CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase
Conclusions: These results suggest that the increased production of CXCL10 from hair follicles induces preferential infiltrates of highly chemoattracted Th1 and Tc1 cells in the acute phase of AA, and Tc1 infiltration remains prolonged in the chronic phase.
Source: Journal of Dermatological Science - January 11, 2013 Category: Dermatology Authors: Taisuke Ito, Hideo Hashizume, Takatoshi Shimauchi, Atsuko Funakoshi, Natsuho Ito, Hidekazu Fukamizu, Masahiro Takigawa, Yoshiki Tokura Tags: Regular articles Source Type: research

Thy-1 knockdown retards wound repair in mouse skin
Conclusion: These data suggest that blocking Thy-1 at wound areas using siRNA reduces repair and affects the re-epithelialization and over-expression of TGF-β1 of the wound during the skin healing process.
Source: Journal of Dermatological Science - January 11, 2013 Category: Dermatology Authors: Min-Jung Lee, Jeong-Oh Shin, Han-Sung Jung Tags: Regular articles Source Type: research

Two Cases of Hand, Foot, and Mouth Disease Involving the Scalp.
Abstract Abstract is missing (Letter). PMID: 23306616 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - January 11, 2013 Category: Dermatology Authors: Lønnberg AS, Elberling J, Fischer TK, Skov L Tags: Acta Derm Venereol Source Type: research

Interobserver Variability of Histopathological Prognostic Parameters in Cutaneous Malignant Melanoma: Impact on Patient Management.
In conclusion, review by a pathologist experienced in melanoma resulted in a change in recommendations about surgical excision margins and/or sentinel node biopsy in subgroups of T1 melanomas. PMID: 23306667 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - January 11, 2013 Category: Dermatology Authors: Eriksson H, Frohm-Nilsson M, Hedblad MA, Hellborg H, Kanter-Lewensohn L, Krawiec K, Lundh Rozell B, Månsson-Brahme E, Hansson J Tags: Acta Derm Venereol Source Type: research

Remitting Seronegative Symmetrical Synovitis with Pitting Oedema (RS3PE) of Hands and Feet in an 83-year-old Man.
Abstract Abstract is missing (Letter). PMID: 23306831 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - January 11, 2013 Category: Dermatology Authors: Nygaard U, Vestergaard C, Koppelhus U Tags: Acta Derm Venereol Source Type: research

Serum-soluble Herpes Virus Entry Mediator Levels Reflect Disease Severity and Th2 Environment in Cutaneous T Cell Lymphoma.
Abstract Abstract is missing (Letter). PMID: 23306973 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - January 11, 2013 Category: Dermatology Authors: Miyagaki T, Sugaya M, Suga H, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S Tags: Acta Derm Venereol Source Type: research

Comparison of three screening tools to detect psoriatic arthritis in patients with psoriasis (CONTEST study).
CONCLUSION: Although the PEST and ToPAS questionnaires performed slightly better than the PASE questionnaire at identifying PsA, there is little difference between these instruments. These screening tools do identify many cases of musculoskeletal disease other than PsA. PMID: 23311587 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 11, 2013 Category: Dermatology Authors: Coates LC, Aslam T, Al Balushi F, Burden AD, Burden-Teh E, Caperon AR, Cerio R, Chattopadhyay C, Chinoy H, Goodfield MJ, Kay L, Kelly S, Kirkham BW, Lovell CR, Marzo-Ortega H, McHugh N, Murphy R, Reynolds NJ, Smith CH, Stewart EJ, Warren RB, Waxman R, Wil Tags: Br J Dermatol Source Type: research

[Influence of ecological groups on the in vitro antifungal susceptibility of dermatophytic fungi.]
CONCLUSIONS: : Azole derivatives showed a similar antifungal profile, being more active against anthropophilic > zoophilic > geophilic. Activity of TRB and AMR was different from azole derivatives (zoophilic > anthropophilic > geophilic). A higher in vitro antifungal activity against the three ecological groups was observed with TRB and AMR, whilst BFZ was the less active drug. PMID: 23318162 [PubMed - as supplied by publisher]
Source: Revista Iberoamericana de Micologia - January 11, 2013 Category: Biology Authors: Carrillo-Muñoz AJ, Tur-Tur C, Cárdenes D, Rojas F, Giusiano G Tags: Rev Iberoam Micol Source Type: research

Distribution of polyethylene glycol coated quantum dots in mice skin
Abstract The distribution of nanoparticles (NP) in an organism is an important issue for developing NP–based drug delivery systems and for general nanotoxicology. The knowledge of NP localisation in the skin is crucial for the optimisation of NP behaviour in vivo. Therefore, we have used semiconductor quantum dots (QD) to investigate their biodistribution in the skin by means of confocal fluorescence microscopy after subcutaneous injection. The results obtained showed that the diffusion of QD in the dermis is limited by basement membrane and dense connective tissue fibres which resulted in negligible QD penetration into ...
Source: Experimental Dermatology - January 11, 2013 Category: Dermatology Authors: Vytautas Kulvietis, Edvardas Zurauskas, Ricardas Rotomskis Tags: Letter to the Editors Source Type: research

Photodynamic inhibition of Trichophyton rubrum: in vitro activity and the role of oxidative and nitrosative bursts in fungal death
Conclusions Photodynamic inhibition was more efficient in promoting cell death than the antifungal cyclopiroxolamine against T. rubrum. ROS, ONOO· and NO· were important in the fungicidal activity of aPI. A suggested mechanism for this activity is that TBO is excited by LED light (630 nm), reacts with biomolecules and increases the availability of transition electrons and substrates for nitric oxide synthase, thereby increasing the oxidative and nitrosative bursts in the fungal cell.
Source: Journal of Antimicrobial Chemotherapy - January 11, 2013 Category: Microbiology Authors: Baltazar, L. d. M., Soares, B. M., Carneiro, H. C. S., Avila, T. V., Gouveia, L. F., Souza, D. G., Ferreira, M. V. L., Pinotti, M., Santos, D. d. A., Cisalpino, P. S. Tags: Original research Source Type: research

Temperament and character properties of primary focal hyperhidrosis patients
Conclusion: Temperament and character features of PFH patients were different from healthy group and it was considered that these features were affected by many factors including genetic, biological, environmental, and socio-cultural elements. During the follow-up of PFH cases, psychiatric evaluation is important and psychotherapeutic interventions can increase the chances of success of the dermatological treatments and can have a positive impact on the quality of life and social cohesion of chronic cases.
Source: Health and Quality of Life Outcomes - January 11, 2013 Category: Global & Universal Authors: Mehmet AkDidem DincerBikem HaciomerogluSuleyman AkarsuAlper CinarNergis Lapsekili Source Type: research

Fans of Reality Beauty Shows Twice as Likely to Tan: Study
Practice could make them more susceptible to skin cancer, researchers say
Source: The Doctors Lounge - Oncology - January 11, 2013 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Dermatology, Oncology, News, Source Type: news

Complex Composite Oncologic Chest Wall Defects Reconstructed With Synthetic or Bioprosthetic Mesh Experience Similar Surgical Outcomes When Combined With Soft Tissue Flap Coverage
The traditional approach for reconstruction of thoracic defects following tumor extirpation has been to employ a synthetic prosthesis (i.e. polypropylene and/or methylmethacrylate). Bioprosthetic mesh (i.e. porcine, bovine, or human acellular dermal matrix) has demonstrated advantages over synthetic mesh in abdominal wall reconstruction. The indications, advantages and disadvantages of bioprosthetic vs. synthetic mesh for thoracic reconstruction are not well understood. We hypothesize that patients' outcomes will be superior with bioprosthetic chest wall reconstruction in comparison to synthetic mesh chest wall reconstruction.
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: P.B. Garvey, M.W. Clemens, J.P. Doolittle, D.P. Baumann, S.G. Swisher, C.E. Butler Tags: Oral Session: Thursday 2/7 7:30 AM to 9:30 AM Source Type: research

Transduction Efficiency of Pseudotyped Adeno-Associated Viral Vectors for Gene Transfer in Dermal Fibroblasts to Modulate Wound Healing
Sustained transgene expression and cell specific gene transfer are goals of cutaneous gene therapy. We and others have demonstrated that using a pseudotyping strategy with AAV vectors has the potential to confer a unique cellular tropism and transduction efficiency profile. We hypothesize that pseudotyped AAV vectors may have differential tropism and transduction efficiency under normal and wound conditions.
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: S. Balaji, Y. Dhamija, A. Leung, L. Le, E. Marsh, T.M. Crombleholme, S.G. Keswani Tags: Oral Session: Wednesday 2/6 7:30 AM to 9:30 AM Source Type: research

The Role of Prolyl Hydroxylase Domain-2 and Hif-1alpha in Wound Healing
Hypoxia inducible factor (HIF) -1alpha, part of the heterodimeric transcription factor that mediates cellular response to hypoxia, is critical for the expression of multiple angiogenic growth factors, cell motility, and the recruitment of endothelial progenitor cells. Inhibition of the oxygen-dependent negative regulator of HIF-1alpha, prolyl hydroxylase domain-2 (PHD-2), leads to HIF-1alpha stabilization and mimics various cellular and physiological responses to hypoxia. The roles of PHD-2 in the epidermal and dermal compartments have not been clearly defined in relation to wound healing.
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: A.S. Zimmermann, S.D. Morrison, M. Sorkin, G.C. Gurtner, M.T. Longaker Tags: Oral Session: Wednesday 2/6 7:30 AM to 9:30 AM Source Type: research

Corrigendum to “Histone deacetylases inhibitor Trichostatin A ameliorates DNFB-induced allergic contact dermatitis and reduces epidermal Langerhans cells in mice” [J. Dermatol. Sci. 68 (2) (2012) 99–107]
The authors wish to inform the readers of a needed clarification in this published article regarding the name of the third author which they incorrectly provided; ‘Jun-Yang Park’ was incorrect and should instead read as ‘Jang-June Park’.
Source: Journal of Dermatological Science - January 10, 2013 Category: Dermatology Authors: Yu-Ling Shi, Jun Gu, Jang-June Park, Ying-Ping Xu, Fu-Shin Yu, Li Zhou, Qing-Sheng Mi Tags: Corrigendum Source Type: research

Long‐term safety of ustekinumab in patients with moderate‐to‐severe psoriasis: final results from 5 years of follow‐up
ConclusionsNo dose‐related or cumulative toxicity was observed with increasing duration of ustekinumab exposure for up to 5 years. Rates of AEs reported in ustekinumab psoriasis trials are generally comparable to those reported for other biologics approved for the treatment of moderate‐to‐severe psoriasis.
Source: British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: K.A. Papp, C.E.M. Griffiths, K. Gordon, M. Lebwohl, P.O. Szapary, Y. Wasfi, D. Chan, M.‐C. Hsu, V. Ho, P.D. Ghislain, B. Strober, K. Reich, Tags: Original Article Source Type: research

Atopic Dermatitis: Update and Proposed Management Algorithm.
Abstract Atopic dermatitis is a chronic inflammatory disease that affects 20% of children and almost 3% of adults and is associated with considerable impairment of quality of life for both patients and their families. While the condition resolves spontaneously after puberty in over 75% of cases, it can persist into adulthood. Furthermore, in young children severe forms can have serious health consequences and affect social development. There are no appropriate guidelines on how to handle cases that do not respond to routine treatment. In this article, we review the current treatments for moderate to severe atopic d...
Source: Actas Dermo-Sifiliograficas - January 10, 2013 Category: Dermatology Authors: Garnacho-Saucedo G, Salido-Vallejo R, Moreno-Giménez JC Tags: Actas Dermosifiliogr Source Type: research

An Unusual Form of Lupus Erythematosus Profundus Associated with Antiphospholipid Syndrome: Report of Two Cases.
Abstract Abstract is missing (Letter). PMID: 23303396 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - January 10, 2013 Category: Dermatology Authors: Arai S, Katsuoka K, Eto H Tags: Acta Derm Venereol Source Type: research

Nasal Tip Cutaneous Metastases Secondary to Lung Carcinoma: Three Case Reports and a Review of the Literature.
We report here 3 cases of cutaneous metastatic carcinoma of the nose that originated from lung cancer. Two men, age 61 and 76 years, with lung cancers were referred for evaluation of a tumour on the tip of the nose. The third patient, a 57-year-old man, had developed a rosacea-like tumour on the tip of the nose; although he had no history of internal cancer, whole-body positron-emission tomography-computed tomography revealed a primary lung cancer. Skin biopsies of all 3 cases showed metastatic squamous cell carcinoma, and all primary lung cancers were squamous cell carcinomas. Only 3 patients are described here, and furth...
Source: Acta Dermato-Venereologica - January 10, 2013 Category: Dermatology Authors: Chun SM, Kim YC, Lee JB, Kim SJ, Lee SC, Won YH, Yun SJ Tags: Acta Derm Venereol Source Type: research

Self-Inflicted Lesions in Dermatology: Terminology and Classification - A Position Paper from the European Society for Dermatology and Psychiatry (ESDaP).
Abstract The terminology, classification, diagnosis and treatment of self-inflicted dermatological lesions are subjects of open debate. The present study is the result of various meetings of a task force of dermatologists, psychiatrists and psychologists, all active in the field of psychodermatology, aimed at clarifying the terminology related to these disorders. A flow chart and glossary of terms and definitions are presented to facilitate the classification and management of self-inflicted skin lesions. Several terms are critically discussed, including: malingering; factitious disorders; Münchausen's syndrome; s...
Source: Acta Dermato-Venereologica - January 10, 2013 Category: Dermatology Authors: Gieler U, Consoli SG, Tomás-Aragones L, Linder DM, Jemec GB, Poot F, Szepietowski JC, de Korte J, Taube KM, Lvov A, Consoli SM Tags: Acta Derm Venereol Source Type: research

Recognized Occupational Skin Cancer in Denmark - Data From the Last Ten Years.
Abstract Abstract is missing (Letter). PMID: 23303569 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - January 10, 2013 Category: Dermatology Authors: Carøe TK, Ebbehøj NE, Wulf HC, Agner T Tags: Acta Derm Venereol Source Type: research

New Insights into Associated Co-morbidities in Patients with Cutaneous T-cell Lymphoma (Mycosis Fungoides).
This study investigated the association between MF and malignancies, anxiety and depression in the Israeli population. Data on Israeli patients with MF and age- and gender-matched controls were collected from a database of population- based cohort (683 patients; 1,700 controls) and an institution- based cohort (343 patients; 846 controls) and analysed by univariate and multivariate methods. MF was significantly associated with Hodgkin's lymphoma in both cohorts (multivariate odds ratio (OR) 7.83, univariate OR ∞, respectively); acute leukaemia (multivariate OR 10.1, first cohort) and lung cancer (multivariate OR 10.15, s...
Source: Acta Dermato-Venereologica - January 10, 2013 Category: Dermatology Authors: Hodak E, Lessin S, Friedland R, Freud T, David M, Pavlovsky L, Shapiro J, Cohen AD Tags: Acta Derm Venereol Source Type: research

Gene Expression Analysis of the Corticotrophin-releasing Hormone-proopiomelanocortin System in Psoriasis Skin Biopsies.
Abstract The corticotrophin-releasing hormone-proopiomelano-cortin (CRH-POMC) system in the skin coordinates pigmentation and the immune response. The aim of this study was to evaluate the regulatory role of the neuroendocrine system in the pathogenesis of psoriasis. Using quantitative real-time-PCR, mRNA expression levels of 15 genes related to the CRH-POMC system were measured in punch biopsies from lesional and non-lesional skin of patients with psoriasis and from skin of healthy control subjects. Statistically significant up-regulation of POMC, CRH receptor type 1, melanin-concentrating hormone receptor (MCHR1)...
Source: Acta Dermato-Venereologica - January 10, 2013 Category: Dermatology Authors: Loite U, Kingo K, Reimann E, Reemann P, Vasar E, Silm H, Kõks S Tags: Acta Derm Venereol Source Type: research

Risk Factors for Non-melanoma Skin Cancer in Kidney Transplant Patients in a Spanish Population in the Mediterranean Region.
Abstract Non-melanoma skin cancer (NMSC) is the most frequent malignancy in organ transplant recipients. The aetiology of NMSC after transplant is multifactorial. The aim of this study was to determine the clinical and environmen-tal factors involved in the development of NMSC in a Spanish kidney transplant population from the Mediterranean region. A total of 289 patients who had received a kidney transplant during the period January 1996 to December 2010 were included in the study. Both prospective and retrospective data were used. All patients underwent a structured interview and a complete examination of the ski...
Source: Acta Dermato-Venereologica - January 10, 2013 Category: Dermatology Authors: García JB, Suárez-Varela MM, Vilata JJ, Marquina A, Pallardó L, Crespo J Tags: Acta Derm Venereol Source Type: research

Determinants of personal UVR exposure-doses on a sun-holiday.
CONCLUSION: The behaviour of the volunteers had a major impact on their personal UVR-doses. Our results emphasize the importance of changing the behaviour among sun seekers with pro-tanning attitudes to reduce their personal annual UVR-exposure-doses and possibly their risk of skin cancer. PMID: 23301517 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Petersen B, Thieden E, Philipsen PA, Heydenreich J, Young AR, Wulf HC Tags: Br J Dermatol Source Type: research

Small diameter melanocytic lesions: morphological analysis by means of in vivo confocal microscopy.
CONCLUSIONS: small melanomas frequently reveal specific dermoscopic and confocal features. Moreover the combination of dermoscopy and RCM can lead to a correct diagnosis of a quote of naevi that share some morphologic aspects with melanomas. PMID: 23301553 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Pupelli G, Longo C, Veneziano L, Cesinaro AM, Ferrara G, Piana S, Moscarella E, Ricci C, Zalaudek I, Seidenari S, Argenziano G, Pellacani G Tags: Br J Dermatol Source Type: research

'Addressing' an under-recognised cause of discomfort for patients undergoing Mohs micrographic surgery.
Abstract Mohs micrographic surgery (MMS) is acknowledged as the gold-standard treatment for high risk non-melanoma skin cancer of the head and neck. By virtue of its tissue-sparing nature, patients who undergo MMS may require several stages or 'layers' to successfully extirpate a tumour. Under such circumstances it is commonplace for adhesive dressings to be applied between each stage to cover an exposed wound bed and act as a temporary pressure dressing to reduce the risk of bleeding. PMID: 23301598 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Parker J, Norman D, Savage L, Hussain W Tags: Br J Dermatol Source Type: research

Long-term safety of ustekinumab in patients with moderate-to-severe psoriasis: final results from five years of follow-up.
CONCLUSIONS: No dose-related or cumulative toxicity was observed with increasing duration of ustekinumab exposure for up to five years. Rates of AEs reported in ustekinumab psoriasis trials are generally comparable to those reported for other biologics approved for the treatment of moderate-to-severe psoriasis. PMID: 23301632 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Papp KA, Griffiths CE, Gordon K, Lebwohl M, Szapary PO, Wasfi Y, Chan D, Hsu MC, Ho V, Ghislain PD, Strober B, Reich K, The PHOENIX 1, PHOENIX 2, ACCEPT Investigators Tags: Br J Dermatol Source Type: research

The natural history of eczema from birth to adult life: a cohort study.
CONCLUSIONS: Predisposed infants and children with eczema usually grow out of the disease, but in adolescence it is more likely to persist. Adult eczema is related to atopy from the age of three months. PMID: 23301666 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Burr ML, Dunstan FD, Hand S, Ingram JR, Jones KP Tags: Br J Dermatol Source Type: research

Double blind randomized pilot trial evaluating the efficacy of oral propranolol on infantile hemangiomas in infants less than 4 months of age.
Abstract Since our report of the ability of propranolol to shrink alarming infantile hemangiomas (IHs) (1,2), propranolol has become the first line therapy for life threatening IHs (3-5). Recently, a randomized clinical trial versus placebo has confirmed the safety and efficacy of 2mg/kg daily oral propranolol in children aged between 9 weeks and 5 years in focal and segmental IH (6). However, the latter study have focused on severe forms of IH, with sometimes a late onset of treatment in a heterogeneous population In the present monocentric pilot randomized, double-blind, placebo controlled clinical trial, we test...
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Léauté-Labrèze C, de la Roque ED, Nacka F, Abouelfath A, Grenier N, Rebola M, Ezzedine K, Moore N Tags: Br J Dermatol Source Type: research

Ichthyosis vulgaris - the filaggrin mutation disease.
Abstract Ichthyosis vulgaris is caused by loss-of-function mutations in the filaggrin gene (FLG) and characterized clinically by xerosis, scaling, keratosis pilaris, palmar and plantar hyperlinearity, and a strong association with atopic disorders. According to published studies presented in this review article, FLG mutations are observed in approximately 7.7% of Europeans and 3.0% of Asians, but appear to be infrequent in darker-skinned populations. This clinical review article provides an overview of ichthyosis vulgaris, epidemiology, related disorders and pathomechanisms. Not only does ichthyosis vulgaris posses...
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Thyssen JP, Godoy-Gijon E, Elias PM Tags: Br J Dermatol Source Type: research

Humoral and cell-mediated autoimmunity in lichen sclerosus.
Abstract We read with great interest the paper of Edmonds et al. (1) who observed that men with penile lichen sclerosus (PLS) have significantly increased extracellular matrix protein 1 (ECM1) serum levels when compared to healthy controls (HC). Similar results were previously found in women with vulvar LS (VLS).(2) Edmonds et al. 1 postulated that anti-ECM1 antibodies are not the causative mechanism but present an epiphenomenon in LS. Nevertheless, there is evidence for humoral as well as cell-mediated autoimmunopathogenic mechanisms driving LS.(1-5). PMID: 23301780 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Gambichler T, Belz D, Terras S, Kreuter A Tags: Br J Dermatol Source Type: research

Development of a Novel PCR-ELISA Assay for the Diagnosis of Trichophyton rubrum Onychomycosis.
In conclusion, we have optimized a target gene and DNA extraction method for rapid detection of T. rubrum onychomycosis. PMID: 23301809 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Pankewitz F, Nenoff P, Uhrlaß S, Bezold G, Winter I, Gräser Y Tags: Br J Dermatol Source Type: research

Clinical and epidemiological comparison of patients affected by palmoplantar plaque psoriasis and palmoplantar pustulosis: a case-series study.
CONCLUSIONS: Our data suggest a close relationship between PPP and psoriasis. The existing data concerning epidemiology, clinical presentation, genetics, histopathology and pathogenesis do not permit a clear distinction between these two entities, which seem to coincide in many aspects. PPP appears to have a marked predilection among female smokers. PMID: 23301847 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Brunasso AM, Puntoni M, Aberer W, Delfino C, Fancelli L, Massone C Tags: Br J Dermatol Source Type: research

Digital compression of facial arteries facilitates cutaneous nasal surgery.
Abstract Non-melanoma skin cancers on the nose frequently present to dermatology for surgical excision. This anatomical area has an excellent vascular supply and, consequently, increased intra-operative bleeding (Fig. 1 (a)). Pinching the nasal tip to control bleeding is commonly used, however this can be uncomfortable for the patient because the nasal septum may not be anaesthetised (Fig. 1 (b)). PMID: 23301876 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Moran B, Foley C, Ormond P Tags: Br J Dermatol Source Type: research

Cholinergic Urticaria Responding to Botulinum Toxin injection for Axillary Hyperhidrosis.
Abstract A 43 year old caucasion gentleman had been receiving Botulinum toxin type A injections (BOTOX(®) , Allergan) for his axillary hyperhidrosis since 2004 with good effect. In June 2009 he gave an 18 month history of developing small prutitic wheals on his chest, arms and to a lesser extent his legs and back.. The lesions lasted between 5 and 120mins. There was no dermographism. Triggers included anxiety, physical exercise and hot showers. PMID: 23301956 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Sheraz A, Halpern S Tags: Br J Dermatol Source Type: research

Dermoscopy of subungual haemorrhage: Its usefulness in the differential diagnosis from nail unit melanoma.
CONCLUSIONS: Dermoscopy provides valuable information for the diagnosis of subungual haemorrhage and aids in the differential diagnosis from nail unit melanoma. PMID: 23302009 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Mun JH, Kim GW, Jwa SW, Song M, Kim HS, Ko HC, Kim BS, Kim MB Tags: Br J Dermatol Source Type: research

Second primary melanomas under BRAF blockers: study by Reflectance Confocal Microscopy.
CONCLUSIONS: Although the clinical relevance of such findings remains questionable, RCM allowed to observe, at cellular level, the earliest events occurring within Vemurafenib-induced changing moles. Moreover repeated RCM examinations permitted to confirm that microscopic marked atypias that led to the histopathological diagnosis of melanoma appeared under treatment and were not preexisting. PMID: 23302038 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: Debarbieux S, Dalle S, Depaepe L, Poulalhon N, Balme B, Thomas L Tags: Br J Dermatol Source Type: research

Dermoscopy of subungual haemorrhage: Its usefulness in the differential diagnosis from nail unit melanoma
ConclusionsDermoscopy provides valuable information for the diagnosis of subungual haemorrhage and aids in the differential diagnosis from nail unit melanoma.
Source: British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: J.‐H. Mun, G..‐W. Kim, S.‐W. Jwa, M. Song, H.‐S. Kim, H.‐C. Ko, B.‐S. Kim, M.‐B. Kim Tags: Original Article Source Type: research

Second primary melanomas under BRAF blockers: study by Reflectance Confocal Microscopy
ConclusionsAlthough the clinical relevance of such findings remains questionable, RCM allowed to observe, at cellular level, the earliest events occurring within Vemurafenib‐induced changing moles. Moreover repeated RCM examinations permitted to confirm that microscopic marked atypias that led to the histopathological diagnosis of melanoma appeared under treatment and were not preexisting.
Source: British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: S. Debarbieux, S. Dalle, L. Depaepe, N. Poulalhon, B. Balme, L. Thomas Tags: Original Article Source Type: research

Determinants of personal UVR exposure‐doses on a sun‐holiday
ConclusionThe behaviour of the volunteers had a major impact on their personal UVR‐doses. Our results emphasize the importance of changing the behaviour among sun seekers with pro‐tanning attitudes to reduce their personal annual UVR‐exposure‐doses and possibly their risk of skin cancer.
Source: British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: B. Petersen, E. Thieden, P.A. Philipsen, J. Heydenreich, A.R. Young, H.C. Wulf Tags: Original Article Source Type: research

‘Addressing’ an under‐recognised cause of discomfort for patients undergoing Mohs micrographic surgery
Mohs micrographic surgery (MMS) is acknowledged as the gold‐standard treatment for high risk non‐melanoma skin cancer of the head and neck. By virtue of its tissue‐sparing nature, patients who undergo MMS may require several stages or ‘layers’ to successfully extirpate a tumour. Under such circumstances it is commonplace for adhesive dressings to be applied between each stage to cover an exposed wound bed and act as a temporary pressure dressing to reduce the risk of bleeding.
Source: British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: J. Parker, D. Norman, L. Savage, W. Hussain Tags: Correspondence Source Type: research

Small diameter melanocytic lesions: morphological analysis by means of in vivo confocal microscopy
Conclusionssmall melanomas frequently reveal specific dermoscopic and confocal features. Moreover the combination of dermoscopy and RCM can lead to a correct diagnosis of a quote of naevi that share some morphologic aspects with melanomas.
Source: British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: G. Pupelli, C. Longo, L. Veneziano, A.M. Cesinaro, G. Ferrara, S. Piana, E. Moscarella, C. Ricci, I. Zalaudek, S. Seidenari, G. Argenziano, G. Pellacani Tags: Original Article Source Type: research

The natural history of eczema from birth to adult life: a cohort study
ConclusionsPredisposed infants and children with eczema usually grow out of the disease, but in adolescence it is more likely to persist. Adult eczema is related to atopy from the age of three months.
Source: British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: M.L. Burr, F.D.J. Dunstan, S. Hand, J.R. Ingram, K.P. Jones Tags: Concise Communication Source Type: research

Double blind randomized pilot trial evaluating the efficacy of oral propranolol on infantile hemangiomas in infants less than 4 months of age
Since our report of the ability of propranolol to shrink alarming infantile hemangiomas (IHs) (1,2), propranolol has become the first line therapy for life threatening IHs (3‐5). Recently, a randomized clinical trial versus placebo has confirmed the safety and efficacy of 2mg/kg daily oral propranolol in children aged between 9 weeks and 5 years in focal and segmental IH (6). However, the latter study have focused on severe forms of IH, with sometimes a late onset of treatment in a heterogeneous population In the present monocentric pilot randomized, double‐blind, placebo controlled clinical trial, we tested the abilit...
Source: British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: C. Léauté‐Labrèze, E. Dumas la Roque, F. Nacka, A. Abouelfath, N. Grenier, M. Rebola, K. Ezzedine, N. Moore Tags: Correspondence Source Type: research

Humoral and cell‐mediated autoimmunity in lichen sclerosus
We read with great interest the paper of Edmonds et al. 1 who observed that men with penile lichen sclerosus (PLS) have significantly increased extracellular matrix protein 1 (ECM1) serum levels when compared to healthy controls (HC). Similar results were previously found in women with vulvar LS (VLS).2 Edmonds et al. 1 postulated that anti‐ECM1 antibodies are not the causative mechanism but present an epiphenomenon in LS. Nevertheless, there is evidence for humoral as well as cell‐mediated autoimmunopathogenic mechanisms driving LS.1‐5
Source: British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: T. Gambichler, D. Belz, S. Terras, A. Kreuter Tags: Correspondence Source Type: research

Ichthyosis vulgaris ‐ the filaggrin mutation disease
Abstract Ichthyosis vulgaris is caused by loss‐of‐function mutations in the filaggrin gene (FLG) and characterized clinically by xerosis, scaling, keratosis pilaris, palmar and plantar hyperlinearity, and a strong association with atopic disorders. According to published studies presented in this review article, FLG mutations are observed in approximately 7.7% of Europeans and 3.0% of Asians, but appear to be infrequent in darker‐skinned populations. This clinical review article provides an overview of ichthyosis vulgaris, epidemiology, related disorders and pathomechanisms. Not only does ichthyosis vulgaris possess ...
Source: British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: J.P. Thyssen, E. Godoy‐Gijon, P.M. Elias Tags: Review Article Source Type: research

Development of a Novel PCR‐ELISA Assay for the Diagnosis of Trichophyton rubrum Onychomycosis
In conclusion, we have optimized a target gene and DNA extraction method for rapid detection of T. rubrum onychomycosis.
Source: British Journal of Dermatology - January 10, 2013 Category: Dermatology Authors: F. Pankewitz, P. Nenoff, S. Uhrlaß, G. Bezold, I. Winter, Y. Gräser Tags: Original Article Source Type: research