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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 10.

A novel splicing mutation and haplotype analysis of the FECH gene in a Chinese family with erythropoietic protoporphyriaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion We described a novel splicing FECH mutation in a Chinese EPP family and analysed the hypomorphic IVS3-48C allele, which were believed to be responsible for generating the phenotypic symptoms in this family.
Source: Journal of the European Academy of Dermatology and Venereology - November 2, 2009 Category: Dermatology Authors: J Ma, S Xiao, J An, X Wang, Q Xu, Y Dong, Y Feng, J Wang Source Type: journals

Increased mast cell expression of PAR-2 in skin inflammatory diseases and release of IL-8 upon PAR-2 activationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In this study, skin biopsies from both healthy-looking and lesional skin of patients with psoriasis and superficial spreading BCC were collected and the expression of PAR-2 immunoreactivity in tryptase-positive mast cells was analysed. PAR-2 expression was confirmed in vitro in different mast cell populations. Cord-blood derived mast cells (CBMC) were stimulated with a PAR-2 activating peptide, 2-furoyl-LIGRLO-NH2. Consequently, IL-8 and histamine production was analysed in the supernatants. We observed a significant increase in the percentage of mast cells expressing PAR-2 in the lesional skin of psoriasis and BCC patient...
Source: Experimental Dermatology - November 2, 2009 Category: Dermatology Authors: Ricardo Filipe da Silva Carvalho, Gunnar Nilsson, Ilkka Tapani Harvima Source Type: journals

Increased alpha-melanocyte-stimulating hormone (α-MSH) levels and melanocortin receptors expression associated with pigmentation in an NC/Nga mouse model of atopic dermatitisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Please cite this paper as: Increased alpha-melanocyte-stimulating hormone ([alpha]-MSH) levels and melanocortin receptors expression associated with pigmentation in an NC/Nga mouse model of atopic dermatitis. Experimental Dermatology 2009.Abstract: Patients with a specific subtype of atopic dermatitis (AD) display particular patterns of pigmentation, such as ripple pattern pigmentation on the neck, pigmented macules on the lip and diffuse pigmentation. However, the mechanism underlying these patterns has not been determined. The purpose of our research is to investigate the factors influencing this type of pigmentation in ...
Source: Experimental Dermatology - November 2, 2009 Category: Dermatology Authors: Keiichi Hiramoto, Hiromi Kobayashi, Masamitsu Ishii, Eisuke Sato, Masayasu Inoue Source Type: journals

Reflectance confocal microscopy for pigmentary disordersemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This article reviewed the RCM applications in the characterization and management of pigmentary disorders. The application of RCM in pigmentary disorders has been expanded to describe hyper- and hypopigmentary disorders as well as pigmented skin tumors. The great advantages of non-invasive and repetitive examination of RCM may provide its usefulness not only in the diagnosis and management of pigmentary disorders, but also in researching pathogenesis of pigmentary disorders.
Source: Experimental Dermatology - November 2, 2009 Category: Dermatology Authors: Hee Young Kang, Philippe Bahadoran, Jean-Paul Ortonne Source Type: journals

CD40 signalling induces IL-10-producing, tolerogenic dendritic cellsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study was designed to characterize the role of the CD40-CD40L pathway for differentiation and function of human DC. Therefore, iDC were stimulated through CD40-CD40L interaction by transduction of DC with adenoviral vectors encoding for CD40L (Ad-CD40L). Resulting DC (CD40L-DC) were analysed concerning their phenotype, cytokine profile and T cell stimulatory capacity. Transduction induced a DC phenotype comparable to stimulation with proinflammatory cytokines as revealed by upregulation of CD83 and the costimulatory molecules CD80 and CD86. Additionally, Ad-CD40L-induced strong production of IL-12p70 not observed in c...
Source: Experimental Dermatology - November 2, 2009 Category: Dermatology Authors: Andrea Tuettenberg, Sabine Fondel, Kerstin Steinbrink, Alexander H. Enk, Helmut Jonuleit Source Type: journals

Annual evidence update on psoriasisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: NHS Evidence Area: News NHS Evidence - skin disorders has produced its third annual evidence update on psoriasis, timed to correspond with Psoriasis Awareness Week.  The Update includes links to new systematic reviews and guidelines published over the previous year, and a "what's new" analysis discusses the new evidence and its implications for clinical practice.  Please see the link below for details. 
Source: NeLM - Dermatology - November 2, 2009 Category: Dermatology Source Type: organizations

Editorial Boardemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Source Type: journals

Contentsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Source Type: journals

Melanoma: part IIemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Those of us who read journals like the Wall Street Journal are aware that the public craves medical information. Despite this fact and the fact that athletes (Troy Aikman, Dallas Cowboy quarterback), musicians (Danny Federici, drummer for Bruce Springsteen's band, and Bob Marley, both of whom died of melanoma), news reporters (Sam Donaldson), actors (Ewan MacGregor), and politicians and their families (Maureen Reagan and John McCain) have gone public about their melanomas, much of the population are still visiting tanning parlors, sunbathing and burning on the beaches, and not getting regular cutaneous examinations.
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Jane M. Grant-Kels Source Type: journals

Childhood melanomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: Pediatric melanoma is rare but increasing in incidence. Because early diagnosis and treatment improves prognosis, clinicians need to include it as a possible diagnosis when evaluating a pigmented lesion in a pediatric patient. Some risk factors for melanoma include xeroderma pigmentosum, giant congenital melanocytic nevi, dysplastic nevus syndrome, atypical nevi, many acquired melanocytic nevi, family history of melanoma, and immunosuppression. Definitive treatment is with surgical excision. Adjuvant therapies such as chemotherapy, immunotherapy, and radiation therapy can be used in advanced cases.
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Melinda Jen, Michael Murphy, Jane M. Grant-Kels Source Type: journals

Melanoma in the elderly patient: relevance of the aging immune systememail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: The rapidly expanding segment of the aging population with its rising incidence of cutaneous melanoma will present major challenges in therapeutic management. Immune strategies will be important in designing effective treatment of melanoma because it is a highly immunogenic tumor. Aging, however, is associated with dysregulation of the immune system and is likely to affect the success of melanoma treatment in the elderly population. This population represents an ideal in vivo model to study the effects of the aging immune system on the natural history of melanoma in the elderly. We review the epidemiology, histop...
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Upendra P. Hegde, Nitya Chakraborty, Philip Kerr, Jane M. Grant-Kels Source Type: journals

Spitzoid melanomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: Because spitzoid melanoma shares many histopathologic features with Spitz nevus, it is one of the most difficult lesions to diagnose in dermatopathology. Uncertainty exists in the medical literature about how to diagnose melanocytic proliferations including Spitz nevus and spitzoid melanoma. A misdiagnosis of a melanoma as Spitz nevus is one of the most frequent causes of malpractice lawsuits in surgical pathology and dermatopathology. This contribution provides a review of the clinical presentation, histopathology, ancillary studies, treatment, and the differential diagnosis of spitzoid melanoma.
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Hideko Kamino Source Type: journals

Melanoma of the feet: misdiagnosed and misunderstoodemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: Acral lentiginous melanoma of the foot is a relatively rare but often very aggressive variant of melanoma. More commonly identified in patients with darker skin, diagnosis of the lesions is often delayed because the area is not routinely examined by patients or primary care physicians. In addition, these lesions often mimic other entities, including vascular lesions and infections. Greater awareness of this entity and performing appropriate biopsies will result in more timely diagnoses and improved survival.
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Douglas Albreski, Steven Brett Sloan Source Type: journals

Unusual variants of malignant melanomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: Melanoma is as diverse in its presentation as it can be in its behavior. This contribution will review the clinical and histologic features of some of the more unusual variants of malignant melanoma that clinicians and pathologists are likely to encounter. There will be a disproportionate focus on the histopathology and prognosis because the clinical presentation of these lesions is in most cases, elusive, and in some cases, frankly deceptive. The discussion will include desmoplastic melanoma, nevoid melanoma, spitzoid melanoma, angiotropic melanoma, and malignant blue nevus.
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Raymond L. Barnhill, Kapil Gupta Source Type: journals

What sentinel node biopsy in patients with melanoma (or patients whose doctors worry that they could have melanoma) might and might not doemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: The sentinel lymph node biopsy has taught us important lessons about the behavior of melanoma and, perhaps, of melanocytic nevi. It is of proven prognostic importance in patients whose diagnosis of melanoma is clear-cut. Sentinel lymph node biopsy is an imperfect prognostic tool, however, and although the morbidity of the procedure is low, completion lymphadenectomy has a high morbidity rate and unproven benefit. In the setting of a borderline lesion, small nodal deposits must be interpreted with caution.
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Philip E. LeBoit Source Type: journals

Sentinel lymph node biopsy from the vantage point of an oncologic surgeonemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: Sentinel lymph node biopsy has greatly influenced the surgical management of clinically localized primary melanoma. Lymphatic mapping and sentinel lymph node biopsy have been used for the selective management of the draining regional lymph node basin of primary cutaneous melanoma. Oncologic surgeons have adopted this procedure to selectively identify occult nodal status in melanoma patients who are at a higher risk of regional metastasis. The current standard of treatment of tumor-positive sentinel lymph node metastasis is immediate completion lymphadenectomy, but considerable debate surrounds the utility of this...
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Lori L. Wilson Source Type: journals

Mohs micrographic surgery for the treatment of malignant melanomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: Mohs micrographic surgery (MMS) is very successful in the treatment of nonmelanoma skin cancer. Examining 100% of the margin using MMS improves cure rates. This method has obvious appeal in treating melanoma. Evaluating the lateral margins of melanomas using frozen tissue sections is complicated. Some studies have shown that basic frozen sections can be accurate in margin evaluation, but others have shown that they are unreliable. The use of immunostains on frozen sections is one method that may make the analysis of frozen sections more accurate. Other modifications, including the use of rush paraffin sections in...
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: James Whalen, Douglas Leone Source Type: journals

Obstacles to and opportunities for more effective peptide-based therapeutic immunization in human melanomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: Melanoma cells can play a number of tricks to evade the host immune response. They can make themselves invisible to cells of the immune system poised to attack them, elaborate molecules that are frankly immunosuppressive, and can create a microenvironment that is hostile to cells of the immune system. Efforts are underway to institute measures that would make tumor cells more susceptible to immune attack, but these efforts have not been all that successful so far. This contribution reviews the history and the rationale of cancer vaccines, the major obstacles to peptide-based immunization, and a discussion on how ...
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Swagatam Ray, Arvind Chhabra, Shikhar Mehrotra, Nitya G. Chakraborty, Antoni Ribas, James Economou, Bijay Mukherji Source Type: journals

Chemotherapy and biologic therapies for melanoma: do they work?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: The incidence of melanoma is increasing, and the therapeutic options for unresectable disease are limited, resulting in an increase in the death rate. Melanoma is usually resistant to standard chemotherapy, and the response rate for any single agent or combination of agents is 15% to 25%. High-dose interleukin-2 results in prolonged responses in a minority of patients, and biochemotherapy (combinations of chemotherapy, interferon, and interleukin-2) is associated with an improved response rate, but no clear effect on overall survival. A number of promising new agents have entered clinical trials in recent years, ...
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Lucia B. Jilaveanu, Saadia A. Aziz, Harriet M. Kluger Source Type: journals

email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Physicians, and more particularly dermatologists, have always had a bent for discovering the strange and uncommon. Witness the century-old book by Gould and Pyle, Anomalies and Curiosities of Medicine, where the unusual to the macabre are presented, ranging from Duhring's bearded woman to various Siamese twins. More recently, Bondeson gathered additional curiosities in his volume, A Cabinet of Medical Curiosities, such as the two-headed boy of Bengal and the infamous Mary Toft who claimed to have given birth to rabbits.
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Lawrence Charles Parish Tags: Contemporary Dermatology Source Type: journals

The sudden arrival of Marfan syndrome: the Rust family's experienceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
After the wedding we made our first home in a little flat located in a new area, finding a new church and new friends, just like many other young couples that we knew. We were so excited at the birth of our first son in 1968, although noticing that he seemed to be very long – totally filling the crib – and that he had very long slim arms, legs, fingers and toes – and absolutely huge feet! As I breastfed him I remember not quite knowing how to hold him as he seemed to be so big and I, at that time, was very petite! His eyes were beautiful, very bright, and we were absolutely thrilled with the new addition to our fami...
Source: Clinics in Dermatology - November 1, 2009 Category: Dermatology Authors: Diane Rust Tags: Contemporary Dermatology Source Type: journals

Cutaneous lesions as initial signs of interferon α-induced sarcoidosis: report of three new cases and review of the literatureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report three new cases of mono-localized, purely cutaneous IFN[alpha]-induced sarcoidosis. In addition, an extensive review of the literature, with special attention to skin involvement, was performed through a PubMed search. The analysis of the retrieved articles showed that cutaneous lesions are frequent signs of IFN-induced sarcoidosis. Skin involvement is documented in 56% of the reports and it appears among the presenting and diagnostic signs of a sarcoid reaction in 51%. Special attention to dermatologic signs is imperative in the course of IFN therapy because even minimal skin involvement may offer a clue to an e...
Source: Dermatologic Therapy - November 1, 2009 Category: Dermatology Authors: Fabrizio Fantini, Claudia Padalino, Giulio Gualdi, Paola Monari, Alberto Giannetti Tags: SIDeMaST Source Type: journals

Congenital melanocytic naeviemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
, consisting of clusters of naevo-melanocytes, develop in utero. Although many congenital naevi are visible at birth, some may not become evident until later in life. The timing of naevo-melanocyte proliferation, senescence and melanogenesis may all contribute towards determining when a naevus will become clinically manifest on the skin. Besides the fact that congenital melanocytic naevi may be aesthetically displeasing, resulting in a multitude of psychosocial issues, they also increase the risk for developing cutaneous melanoma, leptomeningeal melanoma, neurocutaneous melanocytosis, malformations of the brain and, rarely...
Source: Australasian Journal of Dermatology - November 1, 2009 Category: Dermatology Authors: Ivanka Kovalyshyn, Ralph Braun, Ashfaq Marghoob Tags: PROFESSIONAL DEVELOPMENT PROGRAM Source Type: journals

Tropical dermatology and medicineemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Dermatologic Therapy - November 1, 2009 Category: Dermatology Authors: James J. Nordlund, James Ertle Tags: Introduction Source Type: journals

Lichen Planus Link to Dyslipidemia Foundemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BERLIN — Lichen planus, like psoriasis, appears to be intrinsically associated with an increased prevalence of dyslipidemia, according to a large Israeli case-control study. “Of course, this is a pioneering study and I'd like to see it repeated in other databases. Nevertheless, we suggest that patients with lichen planus might be candidates for dyslipidemia screening,” Dr. Arnon D. Cohen said at the annual congress of the European Academy of Dermatology and Venereology.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: BRUCE JANCIN Tags: News Source Type: journals

Dx of Stage III Melanomas Likely To Rise in 2010: New AJCC staging takes effect next year.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BERLIN — Look for a big jump in the number of melanoma patients diagnosed with stage III disease beginning early next year, when the new American Joint Committee on Cancer classification system takes effect.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: BRUCE JANCIN Tags: News Source Type: journals

Case of the Monthemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A 30-year-old male presented with a 2-year history of recurrent oral ulcers with individual lesions lasting 5 days to 2 weeks. He had recently developed multiple oral ulcers lasting more than 2 weeks bilaterally on the tongue, gum line, and buccal mucosa. What's your diagnosis? See Case of the Month, page 47.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Tags: News Source Type: journals

Vital Signs: Rhode Island Leads U.S. in Health Insurance Mandatesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Tags: News Source Type: journals

Panel Backs Peginterferon for Stage III Melanomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
GAITHERSBURG, MD. — Peginterferon alfa-2b has a favorable risk-benefit ratio as an adjuvant treatment for stage III melanoma, a Food and Drug Administration advisory panel said
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: ELIZABETH MECHCATIE Tags: News Source Type: journals

IL-17A Blocker Shows Early Promise for Psoriasisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BERLIN — Selective inhibition of the proinflammatory cytokine interleukin-17A using a novel fully human monoclonal antibody showed considerable early promise for treatment of psoriasis in a phase II double-blind randomized trial.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: BRUCE JANCIN Tags: News Source Type: journals

‘Donda West Act’ Becomes Law in Californiaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
PHOENIX — California Governor Arnold Schwarzenegger signed a bill into law that raises public awareness about the risks of cosmetic surgery and targets the aggressive marketing of services that make the risks “seem almost nonexistent,” California State Assemblywoman Wilmer Amina Carter said.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: DAMIAN McNAMARA Tags: News Source Type: journals

2010 Travel Health Book Is Now Onlineemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The 2010 edition of the Centers for Disease Control and Prevention's “Yellow Book” on health information for international travelers is now available on-line (www.cdc.gov/travel) and in hard copy. Published by Elsevier, the book, which always has a yellow cover, includes information on topics ranging from jet lag, cruise ship travel, and international adoptions to respiratory conditions, drug-vaccine interactions, and persistent travelers' diarrhea. Some topics such as medical tourism are appearing for the first time. More information can be obtained from www.us.elsevierhealth.com.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Tags: News Source Type: journals

Senate Finance Committee Passes Reform Billemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
WASHINGTON — After months of internal debate, the Senate Finance Committee passed a health care reform bill aimed at expanding health coverage and making health insurance more affordable. The 14-9 vote in favor of the bill was split largely along party lines, with Sen. Olympia Snowe of Maine the lone Republican to cross over and vote for the bill along with 13 Democratic colleagues.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: JOYCE FRIEDEN Tags: News Source Type: journals

IVIG Guidelines Highlight Autoimmune Usesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BUDAPEST, HUNGARY — New European guidelines on high-dose intravenous immunoglobulin therapy in autoimmune dermatologic diseases restrict the first-line indications to toxic epidermal necrolysis, Kawasaki disease, and life-threatening, rapidly progressive cases of dermatomyositis.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: BRUCE JANCIN Tags: News Source Type: journals

Combination Therapy Is ‘Cheap,’ ‘Effective’ for Pemphigusemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BUDAPEST, HUNGARY — When the off-label treatment of severe pemphigus vulgaris using anti–tumor necrosis factor–alpha agents is prohibitively expensive or medically contraindicated, consider treating with the TNF-alpha–lowering combination of sulfasalazine plus pentoxifylline, which proved to be safe and effective in a double-blind, randomized trial.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: BRUCE JANCIN Tags: News Source Type: journals

Fibroblast Injectable Gets Mixed Panel Reviewemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BETHESDA, MD. — A Food and Drug Administration advisory panel cast mixed votes on whether data on an injectable product derived from autologous fibroblast cells had demonstrated that it was safe and effective for treating moderate to severe nasolabial fold wrinkles in adults, the indication for which it is under review for approval.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: ELIZABETH MECHCATIE Tags: News Source Type: journals

TNF Blocker Risk-Benefit Analysis Proves Favorableemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BUDAPEST, HUNGARY — More than 100 psoriasis patients treated with adalimumab, etanercept, or infliximab experienced marked clinical improvement for every patient who developed a serious adverse event, according to a risk-benefit analysis of the major randomized trials of the tumor necrosis factor antagonists.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: BRUCE JANCIN Tags: News Source Type: journals

Ustekinumab Approved With Safety Requirementemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The Food and Drug Administration's approval of ustekinumab for moderate to severe plaque psoriasis—the first interleukin-12 and −23 antagonist to be approved in the United States—is accompanied by requirements for a risk management plan and postmarketing studies that address uncertainties about the long-term safety of the biologic drug.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: ELIZABETH MECHCATIE Tags: News Source Type: journals

Antiangiogenesis Offers New Tactic for Inflammatory Diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BUDAPEST, HUNGARY — Topical or oral antiangiogenic therapy may offer a novel avenue of treatment in inflammatory skin diseases such as psoriasis and rosacea. In what he described as the first proof-of-concept study to show that blocking the vascular endothelial growth factor (VEGF) receptor may provide an entirely new approach to treating chronic inflammatory skin conditions, Dr. Michael Detmar presented highlights of his research during a satellite symposium held in conjunction with the annual meeting of the European Society for Dermatological Research.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: BRUCE JANCIN Tags: News Source Type: journals

Omalizumab Quelled Urticaria in 70% of Patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BERLIN — Omalizumab proved effective and safe in patients with moderate to severe chronic urticaria refractory to antihistamines in a double-blind, placebo-controlled, multicenter trial.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: BRUCE JANCIN Tags: News Source Type: journals

Ustekinumab Found to Help Improve Sexual Function in Psoriasis Patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BERLIN — Impaired sexual function is extremely common in the setting of moderate to severe psoriasis, and ustekinumab therapy reduces these problems by 10-fold. That's a key quality of life finding from the ongoing randomized double-blind phase III PHOENIX-1 and −2 clinical trials of this human monoclonal antibody directed against the proinflammatory cytokines interkeukin-12 and −23, Dr. Lyn Guenther reported at the annual congress of the European Academy of Dermatology and Venereology.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: BRUCE JANCIN Tags: News Source Type: journals

Beware of Long-Lasting Fillers for Lipsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Dr. Glogau is clinical professor of dermatology at the University of California, San Francisco. He is a paid consultant and clinical investigator for Allergan, Revance Therapeutics, and Medicis. He has also served as a clinical investigator for Contura. To respond to this column, e-mail Dr. Glogau at sknews@elsevier.com.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: RICHARD G. GLOGAU Tags: Adviser's Viewpoint Source Type: journals

Your Friendly Neighborhood Dermatologistemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Dr. Rockoff practices dermatology in Brookline, Mass. To respond to this column, e-mail Dr. Rockoff at sknews@elsevier.com. I'm old enough to remember the actor Robert Young in “Father Knows Best.” Because his later hit TV series “Marcus Welby, M.D.” aired when I was in medical school and residency, I never saw a single episode, but his image as the kindly general practitioner who knew everybody in town seeped into my consciousness.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: ALAN ROCKOFF Tags: Under My Skin Source Type: journals

Lettersemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
I oppose board certification in procedural dermatology. Even the title of the fellowship, procedural dermatology, is perplexing. Does this make all of the other dermatologists nonprocedural? The practice of dermatology is, by definition, procedural (“Certification Plan for Procedural Derm Postponed,” September 2009, p. 1).
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: John Cowan, Laurie A. Bankston Tags: Opinion Source Type: journals

Agent Targeting BRAF Mutations Shows Promiseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Berlin — An investigational agent that targets the BRAF mutation and is present in at least half of melanoma patients has shown impressive results in a second phase I trial. Response rates with the oral agent PLX4032 reached an unprecedented 70% in metastatic melanoma, signaling a fundamental shift in the way this deadly disease will be treated.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: PATRICE WENDLING Tags: Cutaneous Oncology Source Type: journals

Mycophenolate Mofetil May Reduce SCC Risk After Transplantemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Budapest, Hungary — Switching renal transplant recipients from azathioprine to mycophenolate mofetil for long-term immunosuppression significantly reduced UVA photosensitivity in a crossover study.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: BRUCE JANCIN Tags: Cutaneous Oncology Source Type: journals

Parents Not Keen on H1N1 Vaccine for Childrenemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Despite clinical evidence suggesting that children are at higher risk for pandemic influenza A(H1N1) complications, only 40% of parents surveyed said they plan to have their children vaccinated against that strain of the flu.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: MICHELE G. SULLIVAN Tags: Infectious Diseases Source Type: journals

CPT Codes for H1N1 Vaccine Are Releasedemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The American Medical Association has created a new Current Procedural Terminology code (90470) and revised an existing code (90663) for use with H1N1 vaccinations, according to a statement from the association.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: Heidi Splete Tags: Infectious Diseases Source Type: journals

CDC Officials Continue to Urge Priority Groups to Receive Pandemic Flu Vaccineemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Vaccination for the pandemic influenza A(H1N1) virus remains critical, because it is medicine's best tool for preventing or moderating infection, officials with the Centers for Disease Control and Prevention continued to stress last month.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: MITCHEL L. ZOLER Tags: Infectious Diseases Source Type: journals

New Cream May Prevent Cold Sore Recurrenceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
San Francisco — A newly approved cream containing 5% acyclovir and 1% hydrocortisone prevented ulcerated lesions in patients with recurrent herpes simplex labialis, compared with both topical acyclovir and placebo, a large multicenter study showed.
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: DOUG BRUNK Tags: Infectious Diseases Source Type: journals