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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.

Polymorphism of glutathione S-transferases M1 and T1: susceptibility to solar keratoses in an Italian populationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Our study, the first on a Mediterranean population, shows the existence of a correlation between SK and the GST T1 null genotype. This result points out significant differences between subjects of different ethnic and geographical origin and warrants further investigation on a larger population, and ethnically different populations.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: F. Guarneri, A. Asmundo, D. Sapienza, A. Gazzola, S. P. Cannavò Source Type: journals

Generalized eruptive lentiginosis induced by chemotherapyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We describe a case of lentiginosis induced by cancer chemotherapy, an extremely rare occurrence.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: D. De, S. Dogra, A. J. Kanwar, U. N. Saikia Source Type: journals

Koilonychia in carpal-tunnel syndromeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: S. B. Cho, S. H. Lee, J. Kim Source Type: journals

Stevens–Johnson syndrome and toxic epidermal necrolysis due to anticonvulsants share certain clinical and laboratory features with drug-induced hypersensitivity syndrome, despite differences in cutaneous presentationsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. SJS/TEN due to anticonvulsants may exhibit some clinical and laboratory features of DIHS. The nature of the cutaneous involvement should be emphasized in the diagnosis of DIHS.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: Y. Teraki, M. Shibuya, S. Izaki Source Type: journals

Postirradiation linear morphoeaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report a 74-year-old woman who was treated with radiotherapy for endometrial carcinoma. About 3.5 years after the first dose of radiotherapy, the patient developed linear morphoea starting from the radiation port and affecting distant, nonirradiated skin. Lesions of radiation-induced morphoea are generally described as well-demarcated, indurated plaques with varying amounts of associated erythema; however, there is no previous publication of unilateral band-like distribution of morphoea associated with radiotherapy, to our knowledge.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: B. N. Akay, H. Sanli, A. O. Heper Source Type: journals

Immunohistochemistry in Kaposi's sarcomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The importance of immunohistochemistry (IHC) to our understanding, ability to confidently diagnose and treat Kaposi's sarcoma (KS) has grown steadily in the past few decades. IHC has been performed on many KS specimen types, with > 100 different primary antibodies. Therefore, it is not surprising that IHC has helped unravel the histogenesis, understand the pathogenesis and facilitate the diagnosis of KS and identify novel therapeutic targets in the disease. This paper reviews the literature on the use of IHC in the study of KS.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: L. Pantanowitz, C. N. Otis, B. J. Dezube Source Type: journals

Mutations in the keratin 9 gene in Pakistani families with epidermolytic palmoplantar keratodermaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. The affected members of all five families possess mutations in the KRT9 gene that severely affect heterodimer formation with the type II keratin partner. The results of our study further underscore the crucial role of K9 protein in the palmoplantar epidermis.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: Y. Shimomura, M. Wajid, J. Weiser, L. Kraemer, A. M. Christiano Source Type: journals

In vitro activity of fluconazole, itraconazole, voriconazole and terbinafine against fungi causing onychomycosisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. The aetiological agents of onychomycosis that we found differ from those found in other countries, suggesting that the heat and humidity of the Colombian climate could favour yeast nail infections. The lowest MICs for Candida species (obtained with voriconazole, followed by itraconazole) may be explained by emerging resistant strains. Against dermatophytes, the lowest MICs were obtained with terbinafine, followed by voriconazole. MIC values for the evaluated agents were higher for non-dermatophyte filamentous fungi than for other fungi. As MIC breakpoints have not yet been established for onychomycosis therapi...
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: J. G. Bueno, C. Martinez, B. Zapata, G. Sanclemente, M. Gallego, A. C. Mesa Source Type: journals

Usefulness of the CD63 basophil activation test in detecting Anisakis hypersensitivity in patients with chronic urticaria: diagnosis and follow-upemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. BAT can be considered a reliable new in vitro method to evaluate A. simplex hypersensitivity in patients with CU, supplementing standardized procedures in both diagnosis and follow-up.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: A. Frezzolini, S. Cadoni, O. De Pità Source Type: journals

Colorimetric measurements of iris colour and their significance in East Asian patients with skin canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Iris colour appears to be a possible skin cancer risk factor in East Asian populations. The larger colour differences seen between sun-protected and sun-exposed skin in men and in patients with skin cancer may have been due to chronic or excessive sun exposure.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: J. W. Kim, S. H. Seo, Y. C. Kye, H. H. Ahn Source Type: journals

Serum interleukin-27 levels in patients with cutaneous T-cell lymphomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: T. Miyagaki, M. Sugaya, S. Shibata, H. Ohmatsu, H. Fujita, K. Tamaki Source Type: journals

Management of acne vulgaris: an evidence-based updateemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This review summarizes clinically important findings from 3 systematic reviews, 1 updated guideline and a selection from the 62 randomized controlled trials (RCTs) published between February 2007 and January 2009 on the topic of acne vulgaris. Low glycaemic-load diets might reduce acne severity but this remains unproven. Written patient information leaflets have not been surpassed by other communication methods. New combination topical treatments have not shown convincing advantages over current combination products such as clindamycin/benzoyl peroxide. Topical dapsone is superior to placebo but has yet to be compared with...
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: J. R. Ingram, D. J. C. Grindlay, H. C. Williams Source Type: journals

An approach to the correlation between vitiligo and autoimmune thyroiditis in Chinese childrenemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. A significant incidence of thyroid dysfunction was found in paediatric patients with nonsegmental vitiligo. As vitiligo usually appears before the development of the thyroid disease, it may be advantageous to screen thyroid functions and antibody levels in all paediatric patients with vitiligo, especially those with nonsegmental vitiligo.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: Y. Yang, X. Lin, W. Fu, X. Luo, K. Kang Source Type: journals

Severe exacerbation of multiple self-healing squamous epithelioma (Ferguson–Smith disease) with radiotherapy, which was successfully treated with acitretinemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We describe the challenging case of a patient presenting with extensive, eruptive mid-facial squamous cell carcinomas (SCCs) and keratoacanthomas (KAs) consequent to radiotherapy. Our patient had a personal and family history of multiple KAs and SCCs. Multiple self-healing squamous epithelioma, otherwise known as Ferguson[ndash]Smith disease, was diagnosed. This case presented a therapeutic challenge to preserve tissue and avoid severe facial disfigurement. We found oral acitretin to be the treatment of choice.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: S. J. Robertson, S. J. Bashir, G. Pichert, A. Robson, S. Whittaker Source Type: journals

c-Kit (CD117) expression in classic Kaposi's sarcomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. The results of our study show that in cases of classic KS there is a high rate of c-Kit immunoreactivity, but c-Kit expression does not show any correlation with HHV8 immunoreactivity.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: N. O. Kandemir, B. D. Gun, B. Bahadir, G. Yurdakan, N. Ozdemir, N. Karadayi, S. O. Ozdamar Source Type: journals

Photochemotherapy for systemic sclerosis: effect on clinical and molecular markersemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. PUVA treatment is associated with a significant improvement in cutaneous symptoms in patients with SSc as measured by the Rodnan score (P < 0.01). Specific lymphocyte markers, adhesion molecules and cytokines are also affected by this treatment, helping to clarify further the mechanism of action of PUVA treatment and our understanding of the primary pathological process.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: N. Usmani, A. Murphy, D. Veale, V. Goulden, M. Goodfield Source Type: journals

Extraocular sebaceous carcinoma expressing oestrogen receptor α and human epidermal growth factor receptor 2email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: A. Wakabayashi, K. Tanese, K. Yamamoto, H. Tanomogi, S. Miyakawa Source Type: journals

Keratotic vascular papules over the feet: a case of Waldenström's macroglobulinaemia-associated cutaneous macroglobulinosisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Waldenström's macroglobulinaemia (WM) is a plasma-cell dyscrasia characterized by the monoclonal proliferation of lymphoplasmacytes. A 48-year-old man presented with a 4-year history of multiple painful, hyperkeratotic deep-seated papules over the pressure areas of both soles. He had a 1-year history of Raynaud's phenomenon, intermittent epistaxis, recurrent vomiting, tingling and numbness, and visual disturbances. Histological examination of a skin biopsy found amyloid-like deposits in the upper and mid dermis involving dermal blood vessels, but apart from periodic-acid[ndash]Schiff, various stains gave negative results ...
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: M. Harnalikar, S. Pande, V. Kharkar, U. Khopkar Source Type: journals

Inhibitory effects of antipsychotic and anxiolytic agents on stress-induced degranulation of mouse dermal mast cellsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Antipsychotic and anxiolytic agents may be effective treatments for stress-aggravated inflammatory skin diseases by inhibition of mast-cell degranulation.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: T. Shimoda, Z. Liang, H. Suzuki, S. Kawana Source Type: journals

Increased serum B cell-activating factor level in children with atopic dermatitisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Serum BAFF level is high in AE and might be a useful marker for AE.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: H. M. Jee, K. W. Kim, J. Y. Hong, M. H. Sohn, K. E. Kim Source Type: journals

Simple and rapid screening for HLA-Cw*06 in Polish patients with psoriasisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. The low cost, high-throughput capacity and requirement for small sample amounts make this procedure a useful one for HLA-Cw*06 typing in clinical practice and large population studies. We recommend that patients with psoriasis diagnosed before 45 years of age should be considered for diagnostic HLA-Cw*06 typing.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: K. Rębała, A. Szczerkowska-Dobosz, K. Niespodziana, J. Wysocka Source Type: journals

RNA interference silences the human papillomavirus 6b/11 early gene E7 in vitro and in vivoemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. We conclude that HPV-6b/11 E7 gene expression can be specifically modulated by RNAi, which may provide a useful method in the management of CA.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: X. Z. Chen, K. J. Zhu, Y. Xu, X. Y. Tang, X. Z. Cai, X. Zhang, H. Cheng Source Type: journals

Nonpigmenting fixed drug eruption as a possible abortive variant of toxic epidermal necrolysis: immunohistochemical and serum cytokine analysesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nonpigmenting fixed drug eruption (NPFDE) is clinically indistinguishable from Stevens[ndash]Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) in its initial presentation. The traditional paradigm that epidermal changes are absent in NPFDE cannot be easily reconciled with the clinical resemblance to SJS/TEN. We therefore investigated whether NPFDE is pathogenetically different from pigmented FDE (PFDE) or SJS/TEN and which factors are responsible for the lack of hyperpigmentation. NPFDE lesions before challenge were characterized by larger numbers of CD8+ intraepidermal T cells associated with a paucity of melanoc...
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: Y. Mizukawa, T. Shiohara Source Type: journals

Immune reconstitution inflammatory syndrome involving the skinemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. New skin lesions were very common in this cohort, with the majority being women and patients with very low baseline CD4 counts.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: B. Osei-Sekyere, A. S. Karstaedt Source Type: journals

Macrophage migration inhibitory factor in patients with vitiligo and relationship between duration and clinical type of diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Mean serum MIF level of patients with vitiligo was higher than that of controls, indicating that MIF has a role in the pathogenesis of vitiligo.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: G. Serarslan, Z. Yönden, S. Söğüt, N. Savaş, E. Çelik, A. Arpaci Source Type: journals

Deregulation of cell-death pathways as the cornerstone of skin diseasesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Deregulation of cell-death pathways plays a key role in the pathogenesis of various skin diseases. The different types of cell death are mainly defined by morphological criteria, and include apoptosis, autophagic cell death, and necrosis. The process of apoptosis is well characterized at the molecular level and involves the activation of two main pathways, the intrinsic and extrinsic pathways, converging into the execution of apoptosis by intracellular cysteine proteases, called caspases. The relevance and implication of these apoptotic pathways in the pathophysiology of skin diseases, such as toxic epidermal necrolysis, g...
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: N. Zutterman, H. Maes, S. Claerhout, P. Agostinis, M. Garmyn Source Type: journals

Lichen planus in childhood: report of 100 casesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion. Vaccination against hepatitis B has been suggested to be causally related to the onset of LP in various published studies. However, only 16 of our patients had been vaccinated against hepatitis B. If there is a causal relationship, more cases of LP in children may occur in the future, as vaccination against hepatitis B becomes routine in India.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: A. J. Kanwar, D. De Source Type: journals

Do antineutrophil cytoplasmic antibodies (ANCA) play a key role in neutrophilic dermatoses? A case of propylthiouracil-induced neutrophilic dermatosis with positive perinuclear ANCAemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report a case of neutrophilic dermatosis caused by propylthiouracil (PTU), with positive perinuclear antineutrophil cytoplasmic antibodies (p-ANCA). PTU is well known to cause vasculitis associated with positive ANCA titres, and this typically occurs late in the treatment (after months to years). PTU rarely causes neutrophilic dermatoses (three case reports). In the three cases described, ANCA was positive at the outset. Our patient's initial ANCA testing was negative and her positive p-ANCA evolved. This may be because PTU binds to myeloperoxidase (MPO) inside neutrophils, altering its configuration and thus causing an...
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: S. Darné, S. Natarajan, C. Blasdale Source Type: journals

Demethylation of promoter regulatory elements contributes to CD70 overexpression in CD4+ T cells from patients with subacute cutaneous lupus erythematosusemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Demethylation of regulatory elements contributes to CD70 overexpression in CD4+ T cells of patients with SCLE.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: Y. Luo, M. Zhao, Q. Lu Source Type: journals

Topical tazarotene vs. coal tar in stable plaque psoriasisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Tazarotene 0.1% gel has comparable clinical efficacy to CCT 5% ointment. CCT ointment remains a cost-effective therapy for plaque psoriasis.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: U. Kumar, I. Kaur, S. Dogra, D. De, B. Kumar Source Type: journals

Prevalence of acquired melanocytic naevi in Brazilian schoolchildrenemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. In genetically predisposed people, the body-site distribution of AMN in a heterogeneous population (mixed ethnic backgrounds) is similar to that in a homogeneous population and has the same tendency toward potential proliferation of melanocytes in the presence of ultraviolet radiation. Strategies to reduce the incidence of MM should start at an early age. We believe that these findings will have a direct effect on concepts for preventive strategies. Studies in different populations may serve as a starting point for research into the mechanism underlying increasing rates of AMN.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: S. Yarak, M. M. Ogawa, S. Hirata, F. A. de Almeida Source Type: journals

Supraciliary wrinkles and botulinum toxin Aemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Injection of botulinum toxin type A through the temporal hairline to correct supraciliary wrinkles seems to be safe and effective.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: F. Ghalamkarpour, R. M. Robati, F. Aryanejad, P. Toossi Source Type: journals

c-Ski promotes skin fibroblast proliferation but decreases type I collagen: implications for wound healing and scar formationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Because of the important role of fibroblast proliferation and collagen secretion in tissue repair and scar formation, we speculate that c-Ski may be a new candidate molecule for accelerating wound healing and decreasing scar formation.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: X. Liu, P. Li, X.-Y. Chen, Y.-G. Zhou Source Type: journals

A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentiginesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Undecylenoyl phenylalanine 2% is a novel depigmenting agent, which possibly acts as an [alpha]-melanocyte-stimulating hormone antagonist, thus inhibiting melaninogenesis. It achieved a significant lightening of the lesions with minimal side-effects. Most patients were satisfied with the improvement. Undecylenoyl phenylalanine 2% may represent a safe, effective and inexpensive therapeutic alternative for solar lentigines.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: A. C. Katoulis, A. Alevizou, E. Bozi, M. Makris, A. Zafeiraki, N. Mantas, F. Kousta, M. Mistidou, A. Kanelleas, N. G. Stavrianeas Source Type: journals

Are dark-skinned people really protected from ultraviolet radiation?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Dark-skinned people are not completely protected from the effects of UVR.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: A. L. Young, S. Levy, M. Nighland, R. Grossman, D. N. Silvers, J. T. Celebi Source Type: journals

Effects of hyaluronan and iodine on wound contraction and granulation tissue formation in rat skin woundsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Hyiodine supports wound healing by stimulating wound contraction and epidermal proliferation and by keeping the wound moist through increased exudation.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: R. Slavkovsky, R. Kohlerova, A. Jiroutova, M. Hajzlerova, L. Sobotka, E. Cermakova, J. Kanta Source Type: journals

Pemphigus herpetiformis: analysis of the autoantibody profile during the disease course with changes in the clinical phenotypeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Our patient presented features characteristic of PH. Although circulating anti-Dsg3 antibodies were present, the patient had only cutaneous involvement for a long period. Our findings indicate that the proposed Dsg compensation theory cannot always explain the clinical phenotype, changes in which may occur without apparent modification of the autoantibody profile and antibody specificity. Hence, additional factors, such as Fc[gamma]-dependent neutrophil activation, may critically affect the clinical presentation of pemphigus.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: S. Lebeau, R. Müller, I. Masouyé, M. Hertl, L. Borradori Source Type: journals

Serum T helper 1 cytokine levels are greater in patients with alopecia areata regardless of severity or atopyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Increased Th1 serum cytokines (IL-2, IL-12 and interferon-[gamma]) and IL-1ra levels are associated with AA regardless of disease severity or the presence of atopy.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: N. Barahmani, A. Lopez, D. Babu, M. Hernandez, S. E. Donely, M. Duvic Source Type: journals

Coudability hairs: a revisited sign of alopecia areata assessed by trichoscopyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Coudability hairs, more closely perceived by trichoscopy, are useful-markers for disease activity in AA and provide a surrogate-marker for the hair-pull test.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: S. Inui, T. Nakajima, S. Itami Source Type: journals

Association of HLA-DRB1* and keloid disease in an Afro-Caribbean populationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. This study does not support an association between HLA-DRB1* alleles and susceptibility to keloid in people of Afro-Caribbean origin.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: J. J. Brown, W. E. R. Ollier, G. Arscott, A. Bayat Source Type: journals

Randomized controlled trial comparing store-and-forward teledermatology alone and in combination with web-camera videoconferencingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Intraobserver reliability is very high in teledermatology. When history taking and training in digital photography are standardised, a hybrid system with audio is no better than SF alone.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: G. Romero, P. Sánchez, M. García, P. Cortina, E. Vera, J. A. Garrido Source Type: journals

Psychiatric treatments in dermatology: an updateemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This article summarises common psychiatric conditions seen in patients with skin disease, both primary psychiatric disorders and psychiatric disorders secondary to dermatological pathology. Diagnosis of relevant psychiatric conditions such as anxiety, depression, obsessive[ndash]compulsive disorder, delusional parasitosis and dermatitis artefacta, and psychiatric treatments are discussed. It gives an update of psychopharmacology relevant to the dermatologist including important interactions between psychotropic and dermatological agents.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: R. Sambhi, P. Lepping Source Type: journals

Aggressive digital papillary adenocarcinoma: a reviewemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Vigorous treatment of aggressive digital papillary adenocarcinoma (ADPA), including amputation, has been recommended by most authors, but the appropriateness and effectiveness of excision as an alternative to amputation has not been systematically evaluated. To evaluate the appropriateness and effectiveness of excision as an alternative to amputation in the treatment of ADPA, we reviewed the clinical presentations, treatments and patient outcomes presented in case reports on ADPA available on Ovid MEDLINE. We also assessed the results of immunohistochemical staining for proliferation markers in one patient in order to expl...
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: H.-C. Hsu, C.-Y. Ho, C.-H. Chen, C.-H. Yang, H.-S. Hong, Y.-H. Chuang Source Type: journals

Perinatal exposure to endotoxin and the development of eczema during the first 6 years of lifeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion. Endotoxin exposure during infancy is unlikely to have a large long-term effect on the development of eczema, especially the atopic form.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: C.-M. Chen, S. Sausenthaler, W. Bischof, O. Herbarth, M. Borte, H. Behrendt, U. Krämer, H. C. Williams, H.-E. Wichmann, J. Heinrich Source Type: journals

Corticosteroid/cyclophosphamide pulse treatment in South African patients with pemphigusemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Pulse treatment in our setting was associated with minimal morbidity. In the nine patients who relapsed, the regimen was not strictly followed, emphasizing the importance of compliance. Our use of low-dose oral corticosteroids between treatment pulses, early in the management of poorly controlled patients, supports the current modified recommendation of Pasricha.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: F. Shaik, J. Botha, J. Aboobaker, A. Mosam Source Type: journals

Advances in paracoccidioidomycosisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Paracoccidioidomycosis is the most prevalent systemic mycosis in Latin America. It is becoming globally relevant, as increasing numbers of cases have been detected in returning travellers and immigrants from endemic regions. It is characterized by pulmonary involvement, lymphadenopathy, and chronic progression of mucocutaneous lesions. Untreated, systemic disease can be severe and fatal. Skin features are common and characteristic, enabling the dermatologist to diagnose infection early and prevent the development of serious sequelae. This review outlines the clinical features and management of paracoccidioidomycosis and di...
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: M. Ameen, C. Talhari, S. Talhari Source Type: journals

Effect of levothyroxine treatment on clinical symptoms and serum cytokine levels in euthyroid patients with chronic idiopathic urticaria and thyroid autoimmunityemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. These results suggest that levothyroxine treatment is not a reasonable option in euthyroid patients with CIU and thyroid autoimmunity. Augmentation of cytokine production after levothyroxine treatment seems to be related to the immunomodulatory effects of TSH-suppressive treatment.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: S. Kiyici, O. O. Gul, E. B. Baskan, S. Hacioglu, F. Budak, E. Erturk, S. Imamoglu Source Type: journals

Predictors of patient satisfaction with initial diagnosis and management of malignant melanomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. Patients whose initial biopsy was taken by dermatologist were more satisfied than those with a biopsy taken by a GP. The number of visits was an important predictor of patient satisfaction.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: N. Sheth, S. J. Sarker, M. Harries, C. Healy, R. Russell-Jones, K. Acland Source Type: journals

Axillary hair removal with 1064-nm Nd:YAG laser increases sweat productionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. The results of this study confirm that treatment of axillary hair using the 1064-nm Nd:YAG laser can cause hyperhidrosis, and this effect is not transient. We did not evaluate the eccrine glands histologically, which is a limitation of the study.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: F. Aydin, G. S. Pancar, N. Senturk, Y. Bek, E. P. Yuksel, T. Canturk, A. Y. Turanli Source Type: journals

Neurotropin inhibits both capsaicin-induced substance P release and nerve growth factor-induced neurite outgrowth in cultured rat dorsal root ganglion neuronesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions. These results suggest that NTP exerts its antipruritic effects by inhibiting both SP release and neurite outgrowth of cutaneous sensory nerves.
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: K. Taneda, M. Tominaga, S. Tengara, H. Ogawa, K. Takamori Source Type: journals