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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 18.

Bronchial allergen challenges in children – safety and predictors
ConclusionsThe value of using the specific IgE and MCT as predictors was confirmed in a large number of patients. We also showed, for the first time, that the eNO predicted the EAR. The logistic regression model is repeatable with a good accuracy.
Source: Pediatric Allergy and Immunology - January 20, 2013 Category: Allergy & Immunology Authors: Johannes Schulze, Wanda Reinmüller, Eva Herrmann, Martin Rosewich, Markus A. Rose, Stefan Zielen Tags: Original Article Source Type: research

Molecular Dermatology
Methods and Protocolsseries:Methods in Molecular BiologyThe sustained skin research efforts over the past decades has led to the accumulation of a significant collection of information on skin structure and physiology as well as on the pathogenesis of cutaneous diseases. In Molecular Dermatology: Methods and Protocols, leading experts in the field provide a collection of state-of-the-art reliable protocols covering a wide spectrum of techniques ...
Source: Springer Biomedical Sciences titles - January 19, 2013 Category: Biomedical Science Tags: Molecular Medicine Source Type: news

Dynamic tensile properties of human skin - Gallagher AJ, Ni Anniadh A, Bruyere-Garnier K, Ottenio M, Xie H, Gilchrist MD.
The mechanical properties of skin are important for a number of applications including surgery, dermatology, impact biomechanics and forensic science. Studies have shown that the anisotropic effects of skin have been linked to sample orientation with respe...
Source: SafetyLit: All (Unduplicated) - January 19, 2013 Category: Global & Universal Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Systems biology approaches to evaluate arsenic toxicity and carcinogenicity: An overview.
Abstract Long term exposure to arsenic, either through groundwater, food stuff or occupational sources, results in a plethora of dermatological and non-dermatological health effects including multi-organ cancer and early mortality. Several epidemiological studies, across the globe have reported arsenic-induced health effects and cancerous outcomes; but the prevalence of such diseases varies depending on environmental factors (geographical location, exposure level), and genetic makeup (and variants thereof); which is further modulated by several other factors like ethnicity, age-sex, smoking status, diet, etc. It is...
Source: International Journal of Hygiene and Environmental health - January 19, 2013 Category: Environmental Health Authors: Bhattacharjee P, Chatterjee D, Singh KK, Giri AK Tags: Int J Hyg Environ Health Source Type: research

Idiopathic Facial Aseptic Granuloma.
PMID: 23339993 [PubMed - as supplied by publisher]
Source: Actas Dermo-Sifiliograficas - January 19, 2013 Category: Dermatology Authors: Hiraldo-Gamero A, Vera-Casaño A, Sanz-Trélles A Tags: Actas Dermosifiliogr Source Type: research

Papular Mycosis Fungoides on the Legs: A Case Report.
PMID: 23339994 [PubMed - as supplied by publisher]
Source: Actas Dermo-Sifiliograficas - January 19, 2013 Category: Dermatology Authors: Santamarina-Albertos A, Muñoz-Martínez R, Alvarez-Gago T, Miranda-Romero A Tags: Actas Dermosifiliogr Source Type: research

Aggravation of Atopic Dermatitis‐Like Symptoms by Consecutive Low Concentration of Formaldehyde Exposure in NC/Nga Mice
In conclusion, we suggest that increased skin mRNA expressions of IL‐13, IL‐25/IL‐17E and COX‐2 by independent low concentration of FA exposure might be a key factor to exacerbate HDM‐mediated AD‐like skin inflammation.
Source: Experimental Dermatology - January 19, 2013 Category: Dermatology Authors: Ji‐Yun Kim, Mi Sook Jeong, Kui Young Park, Seong Jun Seo Tags: Letter to the Editors Source Type: research

Cutaneous lymphocyte associated antigen (CLA) as a novel predictive marker of TNF‐alpha inhibitor biological therapy in psoriasis
Abstract A considerable number of psoriatic patients shows secondary resistance during long‐term TNF‐alpha inhibitor therapy, necessitating the identification of reliable predictive markers. Predictive role of cutaneous lymphocyte associated antigen (CLA) was investigated. 38 severe psoriatic patients were treated for a 24‐week‐long study period. Clinical responsiveness (PASI) and changes of flow cytometry‐measured peripheral lymphocyte CLA expression (week 0‐2‐6) were statistically analysed. Regarding 24‐week‐long treatment outcome patients were divided into two groups: During the first 6 weeks mean CLA ...
Source: Experimental Dermatology - January 19, 2013 Category: Dermatology Authors: Hajnalka Jókai, József Szakonyi, Orsolya Kontár, Gábor Barna, Dóra Inotai, Sarolta Kárpáti, Péter Holló Tags: Letter to the Editors Source Type: research

P2X7 receptor is required for neutrophil accumulation in a mouse model of irritant contact dermatitis
Abstract Irritant contact dermatitis (ICD) is an inflammatory reaction caused by chemical toxicity on the skin. The P2X7 receptor (P2X7R) is a key mediator of cytokine release, which recruits immune cells to sites of inflammation. We investigated the role of P2X7R in croton oil (CrO)‐induced ICD using in vitro and in vivo approaches. ICD was induced in vivo by CrO application on the mouse ear and in vitro by incubation of murine macrophages and dendritic cells (DCs) with CrO and ATP. Infiltrating cells were identified by flow cytometry, histology and myeloperoxidase (MPO) determination. Effects of the ATP scavenger apyra...
Source: Experimental Dermatology - January 19, 2013 Category: Dermatology Authors: G. L. da Silva, N. D. M. Sperotto, T. J. Borges, C. Bonorino, C. M. Takyia, R. Coutinho‐Silva, M. M. Campos, R. F. Zanin, F. B. Morrone Tags: Regular Article Source Type: research

A lentiviral vector‐based genetic sensor system for comparative analysis of permeability and activity of vitamin D3 analogues in xenotransplanted human skin
In this study, we wish to establish an in vivo model that allows the comparison of permeability and activity of vitamin D3 analogues in human skin. We generate a bipartite, genetic sensor technology that combines efficient lentivirus‐directed gene delivery to xenotransplanted human skin with vitamin D3‐induced expression of a luciferase reporter gene and live imaging of animals by bioluminescence imaging. Based on the induction of a transcriptional activator consisting of the vitamin D receptor fused to the Gal4 DNA‐binding domain, the vitamin D3‐responsive sensor facilitates noninvasive and rapid assessment of per...
Source: Experimental Dermatology - January 19, 2013 Category: Dermatology Authors: Nicklas Heine Staunstrup, Rasmus O. Bak, Yujia Cai, Lars Svensson, Thomas K. Petersen, Cecilia Rosada, Karin Stenderup, Lars Bolund, Jacob Giehm Mikkelsen Tags: Regular Article Source Type: research

International guidelines for the in vivo assessment of skin properties in non‐clinical settings: Part 2. transepidermal water loss and skin hydration
ConclusionIt is anticipated that these guidelines will promote consistent data reporting, which will facilitate inter‐comparison of study results.
Source: Skin Research and Technology - January 19, 2013 Category: Dermatology Authors: Johan du Plessis, Aleksandr Stefaniak, Fritz Eloff, Swen John, Tove Agner, Tzu‐Chieh Chou, Rosemary Nixon, Markus Steiner, Anja Franken, Irena Kudla, Linn Holness Tags: Original Article Source Type: research

3T‐MRI analysis of epidermis and dermis moisturizing using the T2‐mapping sequence
Source: Skin Research and Technology - January 19, 2013 Category: Dermatology Authors: Calzolari Laura, Kastler Adrian, Mac‐Mary Sophie, Humbert Philippe, Kastler Bruno, Aubry Sebastien Tags: Letter to the Editor Source Type: research

Comparing the rates of absorption and weight loss during a desorption test using near infrared spectroscopy
Abstract The importance of determining skin hydration has over the years prompt the development of many instruments and methods, specifically designed to assess this parameter or water contents especially in the stratum corneum, and have greatly matured to suit different anatomical sites and measure multiple attributes. Of those, Near Infrared Spectroscopy (NIRS) has gained wide interest as a precise, safe, fast and noninvasive technique for determining skin hydration due to its high sensitivity to hydrogen bonding and ability to measure the amount of water in skin directly using the intensities of overtone and combination...
Source: Skin Research and Technology - January 19, 2013 Category: Dermatology Authors: M. Qassem, P. A. Kyriacou Tags: Original Article Source Type: research

Smartphone melanoma apps cause for concern
Smartphone applications that claim to be able to diagnose melanoma should be treated with extreme caution, say researchers.
Source: MedWire News - Dermatology - January 18, 2013 Category: Dermatology Source Type: news

Two Percent Of People Have Armpits That Never Smell
Two percent of people carry an unusual form of a specific gene (ABCC11) that means their armpits never smell. The finding came from new research involving 6,495 women who are enrolled in the Children of the 90s study at the University of Bristol, England, and was published in the Journal of Investigative Dermatology. In the study, 117 (2%) of the subjects were lucky enough to carry this gene that allows them to never have to worry about using deodorant...
Source: Health News from Medical News Today - January 18, 2013 Category: Consumer Health News Tags: Genetics Source Type: news

One million Brits can 'dump their deodorants'
Conclusion This is intriguing research following up on the previous finding that a particular DNA sequence variation in the ABCC11 gene is associated with both earwax and armpit sweat odour. One form of the variant is linked with dry earwax and less odorous sweat, while another is linked with wet earwax and more odorous sweat. The researchers did find that there was a link between which variant mothers had and their deodorant usage. However, almost 80% of women with the dry earwax, “non-odorous” variant still reported using deodorant around once a week. The researchers’ results indicate the same may be true for men,...
Source: NHS News Feed - January 18, 2013 Category: Consumer Health News Tags: Lifestyle/exercise Genetics/stem cells Source Type: news

Top Of The List Of Reasons People Visit Doctors Are Skin Problems, Joint Disorders
A new Mayo Clinic Proceedings study shows that people most often visit their health care providers because of skin issues, joint disorders and back pain. Findings may help researchers focus efforts to determine better ways to prevent and treat these conditions in large groups of people. "Much research already has focused on chronic conditions, which account for the majority of health care utilization and costs in middle-aged and older adults," says Jennifer St. Sauver, Ph.D...
Source: Health News from Medical News Today - January 18, 2013 Category: Consumer Health News Tags: Dermatology Source Type: news

Tanning Bed Cancer Risk Double That Of Summer Sun
The risk of skin cancer from tanning beds is two times higher than spending the same length of time in the Mediterranean midday summer sun. The finding came from a new study conducted by a team of researchers at the University of Dundee, Scotland, and published in the British Journal of Dermatology. The scientists examined 400 tanning beds in the UK and measured their levels of ultraviolet (UV) radiation. UV radiation was emitted at levels above British and EU guidelines in nine out of ten beds...
Source: Health News from Medical News Today - January 18, 2013 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Trichodysplasia spinulosa: A benign adnexal proliferation with follicular differentiation associated with polyomavirus.
Abstract Trichodysplasia spinulosa is a rare polyomavirus-associated cutaneous eruption occurring in the setting of immunosuppression. Clinically it is characterised by multiple centrofacial folliculocentric papules with spinous protuberances. The histopathology is distinct and treatment with antiviral agents appears to be the most effective. PMID: 23330716 [PubMed - as supplied by publisher]
Source: The Australasian Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: Lee YY, Tucker SC, Prow NA, Setoh YX, Banney LA Tags: Australas J Dermatol Source Type: research

Recent advances in cutaneous melanoma: towards a molecular model and targeted treatment.
This article reviews the mechanisms of melanoma oncogenesis and classic molecular signalling pathways, targeted treatment approaches based on the molecular model and immunotherapy, and the advent of next-generation sequencing technologies in understanding the complexity of the melanoma pathogenome. In addition to the known somatic activating mutations BRAF and NRAS, exome sequencing has recently identified RAC1, a novel UV-signature gain-of-function mutation. Germline mutations associated with familial melanoma have added a further dimension to the molecular underpinnings of melanoma, implicating BAP1 and MITF as melanoma ...
Source: The Australasian Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: Read J Tags: Australas J Dermatol Source Type: research

Treatment goals for moderate to severe psoriasis: An Australian consensus.
CONCLUSIONS: There is a need to identify and articulate treatment goals for psoriasis. Assessment of psoriasis severity requires both physical scoring (PASI) and consideration of quality of life measures (DLQI). Identification of treatment goals will guide clinicians in treatment decision-making, enhance the availability and appropriate use of therapies and increase patient satisfaction with their care. PMID: 23330815 [PubMed - as supplied by publisher]
Source: The Australasian Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: Baker C, Mack A, Cooper A, Fischer G, Shumack S, Sidhu S, Soyer P, Wu J, Chan J, Nash P, Rawlin M, Radulski B, Foley P Tags: Australas J Dermatol Source Type: research

Use of bleach baths for the treatment of infected atopic eczema.
Abstract Atopic eczema is one of the most common skin disorders in young children and also affects adults. Staphylococcus aureus infection is the most frequent complication of atopic eczema and is involved in the worsening of the disease. Antibiotic therapy against S. aureus has been an important component of treatment for atopic eczema but there are concerns about antibiotic overuse and increasing bacterial resistance. This has led some clinicians to recommend the use of homemade remedies such as bleach baths as an adjunctive treatment for patients with infected atopic eczema, despite the fact that there have be...
Source: The Australasian Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: Barnes TM, Greive KA Tags: Australas J Dermatol Source Type: research

Cerebral vasculitis and multi-focal neurological deficits due to allopurinol-induced hypersensitivity syndrome.
We report the case of a 63-year old woman with DIHS secondary to allopurinol leading to multiple neurological deficits with magnetic resonance imaging findings consistent with a cerebral vasculitis. PMID: 23330880 [PubMed - as supplied by publisher]
Source: The Australasian Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: Lim D, Rademaker M, Asztely F, Ratnaweera M, Coltman G Tags: Australas J Dermatol Source Type: research

Proliferative nodules of undifferentiated spindle cells arising in a large congenital melanocytic naevus.
Abstract Proliferative nodules (PN) are benign lesions that arise in large congenital melanocytic naevi (LCMN). Clinically and histologically they can be difficult to differentiate from malignancies, which are also associated with LCMN. The PN in this case consisted of undifferentiated spindle cells and exhibited unusual histological features including negative stains for melanocytic markers (S100, HMB45 and MelA), negative stain for c-Kit, high mitotic index and unusual morphology of the lesional cells. As a result, a firm histological classification could not be made, which posed a challenge for the clinical mana...
Source: The Australasian Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: Christou EM, Chen AC, Sugo E, Barbaric D, Wargon O Tags: Australas J Dermatol Source Type: research

A low-risk tumour, at a high-risk site? Basal cell carcinoma of the nipple-areola complex.
PMID: 23330607 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: Williams C, Hussain W Tags: Br J Dermatol Source Type: research

DERMASANA (Miconazole Nitrate) Cream [Pure Source]
Updated Date: Jan 18, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - January 18, 2013 Category: Drugs & Pharmacology Source Type: news

Fluorescence diagnosis and photodynamic therapy for Bowen’s disease treatment
Conclusions Fluorescence diagnosis seems a valid diagnostic tool, useful during the follow up of Bowen disease lesions with the advantage of avoiding unnecessary post‐treatment biopsies.
Source: Journal of the European Academy of Dermatology and Venereology - January 18, 2013 Category: Dermatology Authors: M.T. Truchuelo, B. Pérez, M. Fernández‐Guarino, C. Moreno, P. Jaén‐Olasolo Tags: ORIGINAL ARTICLE Source Type: research

Clinical and microscopic evaluation of long‐term (6 months) epilation effects of the ipulse personal home‐use intense pulsed light (IPL) device
Conclusion A highly significant hair density reduction through induction of telogen followed by miniaturization similar to that achieved in professionally delivered permanent laser hair reduction appears to be the major mechanism of hair reduction using home‐use IPL. IPL‐induced damage to the isthmus and upper stem may inhibit or interfere with the hair regrowth process. Longer term studies are required to determine if this observed damage is clinically permanent.
Source: Journal of the European Academy of Dermatology and Venereology - January 18, 2013 Category: Dermatology Authors: M.A. Trelles, C. Ash, G. Town Tags: ORIGINAL ARTICLE Source Type: research

Whole‐body MRI with diffusion‐weighted sequences compared with 18 FDG PET‐CT, CT and superficial lymph node ultrasonography in the staging of advanced cutaneous melanoma: a prospective study
ConclusionsWhole‐body MRI, using diffusion weighted sequences, was a reliable non‐radiating imaging for staging of melanoma and offers the same diagnostic performances than combined CT, PET‐CT and lymph node US.
Source: Journal of the European Academy of Dermatology and Venereology - January 18, 2013 Category: Dermatology Authors: J.C. Jouvet, L. Thomas, V. Thomson, M. Yanes, C. Journe, I. Morelec, L. Bracoud, F. Durupt, F. Giammarile, Y. Berthezene Tags: Original Article Source Type: research

Regulatory T cells in skin lesions and blood of patients with bullous pemphigoid
ConclusionsThese data suggest that the depletion of Tregs and of IL‐10 in patients with BP may be an important factor in the pathogenesis of the disease.
Source: Journal of the European Academy of Dermatology and Venereology - January 18, 2013 Category: Dermatology Authors: E. Antiga, P. Quaglino, W. Volpi, I. Pierini, E. Del Bianco, B. Bianchi, M. Novelli, P. Savoia, M.G. Bernengo, P. Fabbri, M. Caproni Tags: Original Article Source Type: research

Trichodysplasia spinulosa: A benign adnexal proliferation with follicular differentiation associated with polyomavirus
Abstract Trichodysplasia spinulosa is a rare polyomavirus‐associated cutaneous eruption occurring in the setting of immunosuppression. Clinically it is characterised by multiple centrofacial folliculocentric papules with spinous protuberances. The histopathology is distinct and treatment with antiviral agents appears to be the most effective.
Source: Australasian Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: Yvonne Y Lee, Simon C Tucker, Natalie A Prow, Yin Xiang Setoh, Leith A Banney Tags: Brief Report Source Type: research

Recent advances in cutaneous melanoma: towards a molecular model and targeted treatment
This article reviews the mechanisms of melanoma oncogenesis and classic molecular signalling pathways, targeted treatment approaches based on the molecular model and immunotherapy, and the advent of next‐generation sequencing technologies in understanding the complexity of the melanoma pathogenome. In addition to the known somatic activating mutations BRAF and NRAS, exome sequencing has recently identified RAC1, a novel UV‐signature gain‐of‐function mutation. Germline mutations associated with familial melanoma have added a further dimension to the molecular underpinnings of melanoma, implicating BAP1 and MITF as m...
Source: Australasian Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: Jazlyn Read Tags: Review Article Source Type: research

Treatment goals for moderate to severe psoriasis: An Australian consensus
ConclusionsThere is a need to identify and articulate treatment goals for psoriasis. Assessment of psoriasis severity requires both physical scoring (PASI) and consideration of quality of life measures (DLQI). Identification of treatment goals will guide clinicians in treatment decision‐making, enhance the availability and appropriate use of therapies and increase patient satisfaction with their care.
Source: Australasian Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: Christopher Baker, Alexandra Mack, Alan Cooper, Gayle Fischer, Stephen Shumack, Shireen Sidhu, Peter Soyer, Jason Wu, Jonathan Chan, Peter Nash, Morton Rawlin, Barbara Radulski, Peter Foley Tags: Consensus Article Source Type: research

Use of bleach baths for the treatment of infected atopic eczema
Abstract Atopic eczema is one of the most common skin disorders in young children and also affects adults. Staphylococcus aureus infection is the most frequent complication of atopic eczema and is involved in the worsening of the disease. Antibiotic therapy against S. aureus has been an important component of treatment for atopic eczema but there are concerns about antibiotic overuse and increasing bacterial resistance. This has led some clinicians to recommend the use of homemade remedies such as bleach baths as an adjunctive treatment for patients with infected atopic eczema, despite the fact that there have been few p...
Source: Australasian Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: Tanya M Barnes, Kerryn A Greive Tags: Review Article Source Type: research

Cerebral vasculitis and multi‐focal neurological deficits due to allopurinol‐induced hypersensitivity syndrome
We report the case of a 63‐year old woman with DIHS secondary to allopurinol leading to multiple neurological deficits with magnetic resonance imaging findings consistent with a cerebral vasculitis.
Source: Australasian Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: David Lim, Marius Rademaker, Fredrik Asztely, Manjula Ratnaweera, Glenn Coltman Tags: Brief Report Source Type: research

The Eczema Priority Setting Partnership: a collaboration between patients, carers, clinicians and researchers to identify and prioritize important research questions for the treatment of eczema
Conclusions The top 14 treatment uncertainties around the treatment of eczema provide guidance for researchers and funding bodies to ensure that future research answers questions that are important to both clinicians and patients.
Source: British Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: J.M. Batchelor, M.J. Ridd, T. Clarke, A. Ahmed, M. Cox, S. Crowe, M. Howard, S. Lawton, M. McPhee, A. Rani, J.C. Ravenscroft, A. Roberts, K.S. Thomas Tags: EPIDEMIOLOGY AND HEALTH SERVICES RESEARCH Source Type: research

Sun behaviour after cutaneous malignant melanoma: a study based on ultraviolet radiation measurements and sun diary data
Conclusions Patients with CMM limited their UVR dose on days with body exposure, and by using sunscreen further reduced UVR reaching the skin, although only immediately after diagnosis.
Source: British Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: L.W. Idorn, P. Datta, J. Heydenreich, P.A. Philipsen, H.C. Wulf Tags: PHOTOBIOLOGY Source Type: research

Naevus marginatus revisited: a combined organoid and nonorganoid epidermal naevus caused by HRAS mutation
Source: British Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: L. Groesser, T. Vogt, R. Happle, E. Herschberger, M. Mickler, M. Landthaler, C. Hafner Tags: Correspondence Source Type: research

Prognostic subclassifications of T1 cutaneous melanomas based on ulceration, tumour thickness and Clark’s level of invasion: results of a population‐based study from the Swedish Melanoma Register
Conclusions Using a population‐based melanoma register, and combining ulceration, tumour thickness and Clark’s level of invasion, three distinct prognostic subgroups were identified.
Source: British Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: J. Lyth, J. Hansson, C. Ingvar, E. Månsson‐Brahme, P. Naredi, U. Stierner, G. Wagenius, C. Lindholm, Tags: EPIDEMIOLOGY Source Type: research

Phase IIa randomized, placebo‐controlled study of antimicrobial photodynamic therapy in bacterially colonized, chronic leg ulcers and diabetic foot ulcers: a new approach to antimicrobial therapy
Conclusions This first controlled study of PDT in chronic wounds demonstrated significant reduction in bacterial load. An apparent trend towards wound healing was observed; further study of this aspect with larger patient numbers is indicated.
Source: British Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: S. Morley, J. Griffiths, G. Philips, H. Moseley, C. O’Grady, K. Mellish, C.L. Lankester, B. Faris, R.J. Young, S.B. Brown, L.E. Rhodes Tags: THERAPEUTICS Source Type: research

The association between psoriasis and dyslipidaemia: a systematic review
Summary Psoriasis may be associated with dyslipidaemia, a known risk factor for cardiovascular disease. This systematic review aims to synthesize evidence for the association between psoriasis and dyslipidaemia. Through a systematic search using MEDLINE, Embase and the Cochrane Central Register, from 1 January 1980 to 1 January 2012, we identified 25 observational studies that met the inclusion criteria. These 25 studies included over 2·4 million participants, among whom 265 512 were patients with psoriasis. Twenty studies (80%) reported that psoriasis was significantly associated with dyslipidaemia, with odds ratios ...
Source: British Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: C. Ma, C.T. Harskamp, E.J. Armstrong, A.W. Armstrong Tags: SYSTEMATIC REVIEW Source Type: research

Perineural granulomatous inflammation: a potential harbinger of perineural invasion in cutaneous squamous cell carcinoma
Source: British Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: M.M. Dhandha, J.A. Kozel, Q.L. Erickson, C.I. Vidal Tags: Correspondence Source Type: research

‘Cobblestone’ papillomatous linear papules of the upper lip: a new sign of Costello syndrome
Source: British Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: C. Pernet, C. Baumann, H. Cavé, B. Guillot, D. Bessis Tags: Correspondence Source Type: research

A low‐risk tumour, at a high‐risk site? Basal cell carcinoma of the nipple–areola complex
Source: British Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: C. Williams, W. Hussain Tags: Correspondence Source Type: research

Efficacy and safety of secukinumab in the treatment of moderate‐to‐severe plaque psoriasis: a randomized, double‐blind, placebo‐controlled phase II dose‐ranging study
Conclusions Treatment with subcutaneous secukinumab 3 × 75 mg and 3 × 150 mg met the primary outcome of PASI 75 response achievement after 12 weeks, demonstrating efficacy in moderate‐to‐severe psoriasis.
Source: British Journal of Dermatology - January 18, 2013 Category: Dermatology Authors: K.A. Papp, R.G. Langley, B. Sigurgeirsson, M. Abe, D.R. Baker, P. Konno, S. Haemmerle, H.J. Thurston, C. Papavassilis, H.B. Richards Tags: THERAPEUTICS Source Type: research

House dust mite sublingual immunotherapy: a double‐blind, placebo‐controlled study in elderly patients with allergic rhinitis
Conclusions & Clinical RelevanceSublingual allergen‐specific immunotherapy in elderly patients with a HDM allergy to D. pteronyssinus and D. farinae generated a significant clinical improvement in the active group compared with the placebo group, particularly during the heating season. This therapy was well tolerated.
Source: Clinical and Experimental Allergy - January 18, 2013 Category: Allergy & Immunology Authors: A. Bozek, B. Ignasiak, B. Filipowska, J. Jarzab Tags: Original Article Source Type: research

[Clinical Picture] Serum sickness
A 61-year-old man was bitten by a poisonous snake (Taiwan bamboo viper, Viridovipera Stejnegeri) on his right hand 10 days before visiting our dermatology clinic. He received antivenom (polyvalent haemorrhagic) at our emergency department immediately after the accident. He had severe painful erythematous swelling of the right hand and forearm. After intermittent infusion of high dose antivenom he developed fever and arthralgia on multiple large joints with skin rash. On examination, there were multiple non-blanchable, painful purpuric macular patches on both his lower legs and feet ().
Source: LANCET - January 17, 2013 Category: Journals (General) Authors: Jui-Hung Ko, Wen-Hung Chung Tags: Clinical Picture Source Type: research

Rapid Downregulation of Innate Immune Cells, Interleukin-12 and Interleukin-23 in Generalized Pustular Psoriasis with Infliximab in Combination with Acitretin
Dermatology (DOI:10.1159/000346243)
Source: Dermatology - January 17, 2013 Category: Dermatology Source Type: research

Febrile Ulceronecrotic Mucha Habermann Disease: Case Report of a Dark-Skinned Patient
Case Rep Dermatol 2013;5:4–10 (DOI:10.1159/000346742)
Source: Karger Publishers - January 17, 2013 Category: Cancer & Oncology Source Type: research