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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Non‐segmental vitiligo and psoriasis comorbidity – a case‐control study in Italian patients
ConclusionThe presence of vitiligo and even mild psoriasis is significantly correlated with a family history of cardiovascular disease, a factor that requires greater attention and follow‐up with respect to that necessary for vitiligo patients. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - February 27, 2013 Category: Dermatology Authors: M. Arunachalam, F. Dragoni, R. Colucci, S. Berti, E. Crocetti, M. Galeone, R. Conti, S. Moretti Tags: Original Article Source Type: research

EU Watchdog to Review Safety of Bayer Acne DrugEU Watchdog to Review Safety of Bayer Acne Drug
The European Medicines Agency said it had started a formal safety review of Bayer's acne pill Diane 35 and its generic versions, following a request by France. Reuters Health Information (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - February 12, 2013 Category: Dermatology Tags: Family Medicine/Primary Care News Source Type: news

Ethical issues in cutaneous melanoma
Abstract: Early diagnosis of cutaneous melanoma (CM) is associated with the finding of superficial tumors resulting in high cure rates with surgery, whereas those with deeply invasive tumors are at higher risk of recurrence and melanoma-specific mortality. Unfortunately, once metastatic to the visceral organs, CM is usually refractory to the presently available treatment modalities, resulting in uniformly poor outcomes in patients. Educating susceptible populations about the risk of developing CM has played an important role in preventive strategies despite the fact that benefits of primary skin screening are controversial...
Source: Clinics in Dermatology - August 20, 2012 Category: Dermatology Authors: Upendra P. Hegde, Jane M. Grant-Kels Source Type: research

Necrotic Carpal Tunnel Syndrome in a Child
We report the case of a 10‐year‐old child with necrotic CTS secondary to trauma. To our knowledge, this is the first case reported in a child. (Source: Pediatric Dermatology)
Source: Pediatric Dermatology - January 30, 2013 Category: Dermatology Authors: César García Maldonado, Isabel Cristina Valente Duarte de Sousa, Larissa López Cepeda Tags: Case Report Source Type: research

Nutritional Strategies for Frail Older Adults
The objectives of this continuing education article are to analyze the aging process and its effect on the nutritional status of frail older adults; determine how sarcopenia, anorexia, malnutrition, and Alzheimer disease increase the risk for pressure ulcer development and impact the healing process; and to apply evidence-based nutrition guidelines and implement practical solutions for wound healing. (Source: Advances in Skin and Wound Care)
Source: Advances in Skin and Wound Care - February 24, 2013 Category: Dermatology Tags: Features: Clinical Management Extra Source Type: research

Knotig‐pustulöse Hautveränderungen am Finger eines Patienten mit Morbus Crohn
(Source: JDDG)
Source: JDDG - February 4, 2013 Category: Dermatology Authors: Michaela Gronau, Manfred Wolter, Kristina Niedergethmann, Edgar Dippel, Christoph Löser Tags: Diagnosequiz Source Type: research

Isolated painful onycholysis in a 40‐year‐old woman with Crohn's disease
(Source: International Journal of Dermatology)
Source: International Journal of Dermatology - February 22, 2013 Category: Dermatology Authors: Gretchen Frieling, Nicole Velez, Steven R. Tahan, Susan Burgin Tags: Case Report Source Type: research

HER2 protein overexpression and gene amplification in extramammary Paget disease
ConclusionsA subset of EMPD, both intraepithelial and invasive, showed HER2 overexpression and gene amplification. These HER2 alterations were correlated with biologically aggressive EMPDs, i.e, those with deep invasion and lymph node metastasis. Clinical trials of HER2 targeted therapy are waited for the improvement of prognosis of patients with aggressive EMPD. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - January 1, 2013 Category: Dermatology Authors: R. Tanaka, Y. Sasajima, H. Tsuda, K. Namikawa, A. Tsutsumida, F. Otsuka, N. Yamazaki Tags: Original Article Source Type: research

New Drug on Par with Standard for Skin Infections (CME/CE)
(MedPage Today) -- Acute bacterial skin infections responded equally well to treatment with linezolid (Zyvox) or a short course of the investigational agent tedizolid, results of a randomized trial showed. (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - February 12, 2013 Category: Dermatology Source Type: news

Systemic retinoids in the management of ichthyoses and related skin types
Abstract The term retinoid includes both natural and synthetic derivatives of vitamin A. Retinoid‐containing treatments have been used since ∼1550BC by the early Egyptians. Treatment of ichthyosiform disorders with retinoids dates back at least to the 1930s. Early use of high‐dose vitamin A demonstrated efficacy, but because vitamin A is stored in the liver, toxicity limited usefulness. Interest turned to synthetic retinoids in an effort to enhance efficacy and limit toxicity. Acetretin, isotretinoin and, in the past etretinate, have provided the most effective therapy for ichthyosiform conditions. They have been use...
Source: Dermatologic Therapy - February 5, 2013 Category: Dermatology Authors: John J. DiGiovanna, Theodora Mauro, Leonard M. Milstone, Matthias Schmuth, Jorge R Toro Tags: Invited Article Source Type: research

New insight into eczema’s itch
Research shows that innate lymphoid cells accumulate in active eczema lesions and may contribute to disease progression. (Source: MedWire News - Dermatology)
Source: MedWire News - Dermatology - February 1, 2013 Category: Dermatology Source Type: news

mTOR and its downstream signalling components are activated in psoriatic skin
ConclusionsAltogether these results suggest a role for mTOR signalling in the epidermal changes leading to the psoriatic phenotype. mTOR inhibition might be a mode of action suitable to be explored for innovative anti‐psoriatic drugs. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 12, 2013 Category: Dermatology Authors: C. Buerger, B. Malisiewicz, A. Eiser, K. Hardt, W.H. Boehncke Tags: Concise Communication Source Type: research

Pathogenesis‐based therapies in ichthyoses
Abstract During the past 20 years, tremendous progress has been made in our understanding of the molecular basis of many genetic skin conditions. The translation of these laboratory findings into effective therapies for affected individuals has been slow, however, in large part due to the risk of carcinogenesis from random viral genomic integration and the lack of efficacy of topically applied genetic material and most proteins. As intervention at the gene level still appears remote for most genetic disorders, increased knowledge about the cellular and biochemical pathogenesis of disease allows specific targeting of pathwa...
Source: Dermatologic Therapy - February 5, 2013 Category: Dermatology Authors: Joey E. Lai‐Cheong, Peter M. Elias, Amy S. Paller Tags: Invited Article Source Type: research

Researchers ESTABLISH efficacy of tedizolid phosphate for skin infections
Results from the phase III ESTABLISH-1 study show that the new antibiotic tedizolid phosphate is noninferior to linezolid for the treatment of acute bacterial and skin structure infections. (Source: MedWire News - Dermatology)
Source: MedWire News - Dermatology - February 13, 2013 Category: Dermatology Source Type: news

Topical treatment of ichthyoses
Abstract Management of ichthyoses is a complex and continuously dynamic process. Primary treatments of ichthyosis are by means of topical moisturizers and topical medications. Patients and families need to have reasonable and realistic expectations when it comes to topical therapy. Topical medications cannot cure the scaling, but can gradually reduce it and thus improve their condition. No one treatment regimen works for everyone, and the best topical therapy for each patient may be the result of months (or years) of painstaking effort on both the physician's and the patient's behalf. As patients get older and their activi...
Source: Dermatologic Therapy - February 5, 2013 Category: Dermatology Authors: Philip Fleckman, Brandon D. Newell, Maurice A. Steensel, Albert C. Yan Tags: Invited Article Source Type: research

Short flap rhytidectomy and fractional CO2 laser rejuvenation of the aging face
ConclusionsCombination fractional laser resurfacing with short flap, high‐Superficial muscular aponeurotic system rhytidectomy is a safe procedure with excellent patient satisfaction and clinical outcomes. (Source: Journal of Cosmetic Dermatology)
Source: Journal of Cosmetic Dermatology - February 26, 2013 Category: Dermatology Authors: Farhan Taghizadeh, Alicia Leibowitz, Timothy Ellison, Michael Griego, Mimi Traylor‐Knowles, Patrick Ramirez Tags: Original Contribution Source Type: research

Five‐year economic evaluation of non‐melanoma skin cancer surgery at the Costa del Sol Hospital (2006–2010)
ConclusionsThe ABC cost analysis system favours standardization of the care process for these tumours and the detection of areas to improve efficiency. This would enable more reliable economic studies than those obtained using traditional methods, such as the DRG. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - February 26, 2013 Category: Dermatology Authors: M Aguilar‐Bernier, M González‐Carrascosa, L Padilla‐España, F Rivas‐Ruiz, A Jiménez‐Puente, M Troya‐Martín Tags: Original Article Source Type: research

The adoptive transfer of cultured T cells for patients with metastatic melanoma
Abstract: T cells have been shown to be capable of rejecting a patient's tumor. Weak responses to current vaccines and the toxicity of exogenously administered cytokines limit the intensity of the T-cell response that can be actively generated in vivo. Adoptive T-cell transfer enhances an intrinsically weak immune response to cancer by activating and expanding tumor reactive T cells in vitro and manipulating the environment of the host at the time of transfer. One can frequently find tumor-reactive T cells in metastatic lesions in patients with melanoma, and expand them in vitro for readministration. When successful, this ...
Source: Clinics in Dermatology - February 26, 2013 Category: Dermatology Authors: James C. Yang Source Type: research

Immunology of melanoma
Abstract: It can be safely said that human melanomas are immunogenic. Virtually all the major principles of “tumor immunology” have been experimentally established in this model. It is now amply clear that melanoma cells display multiple antigens and peptide epitopes that are targetable by the host immune system and that patients with melanoma are capable of responding to these antigens and epitopes serologically as well as through the cell-mediated mechanisms. The immune responses against melanoma are, however, subject to regulation by the regulatory processes within the immune system itself and melanoma cells can res...
Source: Clinics in Dermatology - February 26, 2013 Category: Dermatology Authors: Bijay Mukherji Source Type: research

Scabies increased the risk of chronic kidney disease: a 5‐year follow‐up study
ConclusionsWe concluded that there was an increased risk for CKD among patients suffering from scabies. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - February 1, 2013 Category: Dermatology Authors: S.‐D. Chung, K.‐H. Wang, C.‐C. Huang, H.‐C. Lin Tags: Original Article Source Type: research