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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 34.

Stairlifts on cell block H: who cares for older prisoners?
The photograph was of a frail man in a wheelchair handcuffed to a prison officer. The article and accompanying photograph appeared in The Guardian highlighting the problem of caring for the increasing numbers of elderly and disabled prisoners.The story focused on the comments by the hospital consultant who criticised the care provide by the prison service claiming it has severely damaged the patient’s health.Concerns over the care of elderly and disable prisoners howeve
Source: HSJ - November 12, 2012 Category: UK Health Source Type: news

Epidemiology of Osteoarthritis
Osteoarthritis (OA) is the most common form of arthritis in the United States and is a leading cause of disability. It is typically defined in epidemiologic studies by radiographic findings and consideration of symptoms. Its incidence and prevalence are rising, likely related to the aging of the population and increasing obesity. Risk factors for OA include numerous person-level factors, such as age, sex, obesity, and genetics, as well as joint-specific factors that are likely reflective of abnormal loading of the joints. In studying OA, several methodologic challenges exist that can hamper our ability to identify pertinent relationships.
Source: Rheumatic Disease Clinics of North America - November 12, 2012 Category: Rheumatology Authors: Tuhina Neogi, Yuqing Zhang Source Type: research

Challenges After the First Decade of Transcatheter Aortic Valve Replacement: Focus on Vascular Complications, Stroke, and Paravalvular Leak
Transcatheter aortic valve replacement (TAVR) is entering its second decade. Three major clinical challenges have emerged from the first decade of experience: vascular complications, stroke, and paravalvular leak (PVL). Major vascular complications remain common and independently predict major bleeding, transfusion, renal failure, and mortality. Although women are more prone to vascular complications, overall they have better survival than men. Further predictors of major vascular complications include heavily diseased femoral arteries and operator experience. Strategies to minimize vascular complications include a multimo...
Source: Journal of Cardiothoracic and Vascular Anesthesia - November 12, 2012 Category: Anesthesiology Authors: Christopher Reidy, Aris Sophocles, Harish Ramakrishna, Kamrouz Ghadimi, Prakash A. Patel, John G.T. Augoustides Tags: Expert Review Source Type: research

Functional somatic syndromes may be either “polysyndromic” or “monosyndromic”
Functional somatic syndromes are probably the most useful description of a group of conditions presenting with physical symptoms and disability for which medicine cannot find presently a convincing explanation . They include common conditions such as irritable bowel syndrome, tension headaches, and fibromyalgia (chronic widespread pain), and less common conditions, such as chronic fatigue syndrome and certain “atypical” regional pain syndromes. Almost all are more common in women than men, and they affect young and middle aged adults most frequently. Premorbid risk markers include childhood adversity and mood disorders...
Source: Journal of Psychosomatic Research - November 12, 2012 Category: Psychiatry & Psychology Authors: Peter D. White Tags: Editorials Source Type: research

Tourette syndrome, parenting aggravation, and the contribution of co-occurring conditions among a nationally representative sample
Conclusion: Parents of children with TS may face significant challenges in raising their children, leading to increased parenting aggravation; these challenges appear to be primarily associated with the presence of co-occurring MEB conditions.
Source: Disability and Health Journal - November 12, 2012 Category: Disability Authors: Lara R. Robinson, Rebecca H. Bitsko, Laura A. Schieve, Susanna N. Visser Tags: Research Papers Source Type: research

Care providers' burden and associated factors of the senile dementia patient care providers in an urban-rural fringe of Fuzhou City, China.
Conclusion: The main influence factors of the caring burden of care providers' for dementia patients were length of daily caring hours, source of care receivers' medical expenses, patient with physical disability and care providers' role awareness (i.e., obligated vs. willing). PMID: 23147753 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - November 12, 2012 Category: Geriatrics Authors: Li H, Zhang H, Huang H, Wang Y, Huang H Tags: Aging Clin Exp Res Source Type: research

Attachment style is associated with perceived spouse responses and pain-related outcomes.
Conclusions/Implications: Findings suggest that attachment style is associated with pain-related outcomes and perceptions of spouse responses. The hypothesized moderation effects for attachment were not found; however, mediation analyses showed that perceived spouse responses may partially explain associations between attachment and adjustment to pain. Future research is needed to clarify how attachment style and the social environment affect the pain experience. (PsycINFO Database Record (c) 2012 APA, all rights reserved)
Source: Rehabilitation Psychology - November 12, 2012 Category: Rehabilitation Authors: Forsythe, Laura P.; Romano, Joan M.; Jensen, Mark P.; Thorn, Beverly E. Source Type: research

Helping people with HIV/AIDS return to work: A randomized clinical trial.
Conclusion: Theoretically based workforce-reentry assistance programs can assist disabled people with HIV/AIDS in their return-to-work efforts. (PsycINFO Database Record (c) 2012 APA, all rights reserved)
Source: Rehabilitation Psychology - November 12, 2012 Category: Rehabilitation Authors: Martin, David J.; Chernoff, Robert A.; Buitron, Michael; Comulada, W. Scott; Liang, Li-Jung; Wong, F. Lennie Source Type: research

Orbitofrontal Dysfunction and Medication Overuse in Patients With Migraine.
CONCLUSIONS: The present findings suggest the presence of a persistent OFC dysfunction in migraine as a psychobiologic trait that is not influenced by the presence of medication overuse, the clinical severity of the disease, or the patient's affective status. Further studies are needed to elucidate the etiopathological role of OFC in migraine and medication overuse. PMID: 23145856 [PubMed - as supplied by publisher]
Source: Headache - November 12, 2012 Category: Neurology Authors: Biagianti B, Grazzi L, Gambini O, Usai S, Muffatti R, Scarone S, Bussone G Tags: Headache Source Type: research

The effect of acupuncture on stroke recovery: study protocol for a randomized controlled trial
This study will evaluate the effects of acupuncture on the long-term recovery of acute stroke and on improving the quality of life of the patients. The results of this study will help establish optimal integrated therapeutic strategies for patients with stroke.Trial registrationCurrent Controlled Trials ISRCTN29932220
Source: BMC Complementary and Alternative Medicine - November 12, 2012 Category: Complementary Medicine Authors: Huilin LiuJingdao LiDangsheng ZhangXiuge TanGuiling WangYin ZhaoYali WenLinpeng Wang Source Type: research

Context-specific, evidence-based planning for scale-up of family planning services to increase progress to MDG 5: health systems research
Conclusion: Local health planners are in a prime position to devise feasible context-specific activities toovercome constraints and increase met need for family planning to accelerate progresstowards MDG 5.
Source: Reproductive Health - November 12, 2012 Category: OBGYN Authors: Abbey ByrneAlison MorganEliana Jimenez SotoZoe Dettrick Source Type: research

Bladder Cancer and Painkillers Connection
Researchers explore connection between popular pain relievers, bladder cancer - Duration of ibuprofen use may be related to a reduced risk, especially in those with certain genetic marker.
Source: Disabled World - November 11, 2012 Category: Disability Tags: Cancer and Tumor Types Source Type: news

Laxatives - Too Many Too Often Dangerous to Health
Overuse and abuse of laxatives can lead to dependence, where the body gets used to being on laxatives. The gut and bowel relax and become unable to move or hold the contents. The body can no longer produce a bowel movement without the help of laxatives.
Source: Disabled World - November 11, 2012 Category: Disability Tags: Digestive System Disorders Source Type: news

Child Prodigies and Autism Link Study
A new study of eight child prodigies suggests a possible link between these children’s special skills and autism. Of the eight prodigies studied, three had a diagnosis of autism spectrum disorders. As a group, the prodigies also tended to have slightly elevated scores on a test of autistic traits, when compared to a control group.
Source: Disabled World - November 11, 2012 Category: Disability Tags: Autism Information Source Type: news

How and When to Decide on Revascularization in Stable Ischemic Heart Disease
Opinion statement Coronary artery disease is the leading cause of death and disability worldwide. While an invasive strategy of early revascularization reduces cardiovascular morbidity and mortality in patients with acute coronary syndromes, there is no convincing evidence that this strategy leads to an incremental survival advantage for patients with stable ischemic heart disease (SIHD) beyond that achieved by optimal medical therapy. Two landmark trials, COURAGE and BARI 2D, suggest that a strategy of aggressive medical therapy is a reasonable initial approach to such patients. However, there remain certai...
Source: Current Treatment Options in Cardiovascular Medicine - November 11, 2012 Category: Cardiology Tags: Current Treatment Options in Cardiovascular Medicine Source Type: research

How Intellect And Behavior Emerge During Childhood
This study helps explain how genetic mutations can cause profound cognitive and behavioral problems. The study was published in the journal Cell...
Source: Health News from Medical News Today - November 11, 2012 Category: Consumer Health News Tags: Autism Source Type: news

Amputee Villains - Portrayal of Amputee's in Film and Theater
Fear. It's a scary word. In the past I've written about my own fears, but now it's time to talk about yours. Well OK, I'm generalizing. I'll call the following a societal fear.
Source: Disabled World - November 10, 2012 Category: Disability Tags: Blogs and Writings Source Type: news

Your Health - Blackberry vs iPhone
The Blackberry vs. iPhone battle has been ongoing since Apple's 2007 phone debut, with no end in sight. That is until today.
Source: Disabled World - November 10, 2012 Category: Disability Tags: Allergies Source Type: news

Impairment and disability: Renoir's adaptive coping strategies against rheumatoid arthritis
Abstract Pierre-Auguste Renoir was one of the most influential painters in art history, but few people know that he suffered from debilitating rheumatoid arthritis. Despite his arthritis, he was able to maintain an incredible level of precision and efficiency with his painting. More importantly, he remained positive and did not let his condition affect his passion for painting or take away from the beauty that he saw in the world around him. Renoir applied a wide variety of coping mechanisms and used his ingenuity to come up with different ways to continue painting even as his arthritis weakened him. Renoir'...
Source: Hand - November 10, 2012 Category: Surgery Tags: Hand Source Type: research

Special Me... the truth about turning 18
What happens when a disabled child turns 18
Source: BBC News | Health | UK Edition - November 10, 2012 Category: Consumer Health News Source Type: news

Exome Sequencing: Potential Diagnostic Assay For Unexplained Intellectual Disability
Research findings confirming that de novo mutations represent a major cause of previously unexplained intellectual disability were presented on Nov. 8 at the American Society of Human Genetics 2012 meeting in San Francisco. Josep de Ligt, M.Sc., bioinformatician and Ph.D...
Source: Health News from Medical News Today - November 10, 2012 Category: Consumer Health News Tags: Genetics Source Type: news

IDS Receives Grant to Provide Additional Funding for Home of Your Own Program
HATTIESBURG, Miss., Nov. 9, 2012 (GLOBE NEWSWIRE) -- The Federal Home Loan Bank of Dallas (FHLB Dallas) and BancorpSouth are pleased to announce they have awarded a $147,000 Affordable Housing Program (AHP) grant to the University of Southern Mississippi Institute for Disability Studies (IDS). The grant will assist in IDS's efforts to provide down payment and closing cost assistance to qualified homebuyers through its Home of Your Own (HOYO) program.
Source: Medical News (via PRIMEZONE) - November 10, 2012 Category: Pharmaceuticals Source Type: news

Are the police and crime commissioner elections too political? | Vera Baird and Simon Weston
Elections for police commissioners will be held next week. Are they a good idea? Former MP Vera Baird is standing, but Falklands veteran Simon Weston pulled outOn Wednesday, 41 police and crime commissioners (PCCs) will be elected across England and Wales. Recent coverage has focused on predictions of record-low turnouts. But what will be the impact of these powerful new figures? Former solicitor general Vera Baird, who is standing for Labour in Northumbria, and Falklands war veteran Simon Weston, who withdrew from the South Wales race, share contrasting views with Susanna Rustin.Vera Baird: The role is to consult the publ...
Source: Guardian Unlimited Science - November 9, 2012 Category: Science Authors: Susanna Rustin Tags: Comment The Guardian Police Features Politics UK news Wales Police and crime commissioners Labour Comment is free Source Type: news

Periventricular hemorrhage: A problem still today
Abstract: Periventricular hemorrhage (PVH) is the result of “temporary” fragile blood vessels and unstable circulation in the brain of very premature infants. Antenatal corticosteroids have substantially reduced PVH. Avoidance of intrapartum hypoxia and birth trauma has probably helped as has better cardio-respiratory stabilization after delivery. Increased survival of the highest risk infants under 26weeks gestation means that there are probably 800–900 infants with severe PVH annually in the UK. Delayed cord clamping could probably reduce PVH further. Various medications can reduce PVH but have not been widely adop...
Source: Early Human Development - November 9, 2012 Category: Perinatology & Neonatology Authors: Andrew Whitelaw Tags: Guest Editor: N. Modi Source Type: research

Forgotten children? An update on young children in institutions across Europe
This article provides an update on a series of projects that have highlighted this issue in Europe, arguing that babies and small children aged less than 3years old, with or without disability, should not be placed in residential care without a parent or primary caregiver. This principle has been discussed by the UN General Assembly (2009) and specific guidelines have been produced for all 193 member states.
Source: Early Human Development - November 9, 2012 Category: Perinatology & Neonatology Authors: Catherine Hamilton-Giachritsis, Kevin Browne Tags: Guest Editor: N. Modi Source Type: research

Geriatric hospitalizations due to fall-related injuries - Limpawattana P, Sutra S, Thavompitak Y, Chindaprasirt J, Mairieng P.
BACKGROUND: Fall is a preventable condition associated with disability and mortality in elders. The overall data regarding admission rates and its impact in Thai elderly are lacking. OBJECTIVE: To identify admission, mortality rates of older persons with f...
Source: SafetyLit: All (Unduplicated) - November 9, 2012 Category: Global & Universal Tags: Age: Elder Adults Source Type: news

Children in difficulties - Pairojkul S, Limratana N.
BACKGROUND: Children in difficulties are characterized by: chronic neglect; disability; physical, emotional or sexual abuse; HIV or one/both parents with HIV and/or limited socio-economic opportunities. OBJECTIVE: To review the current situation by reviewi...
Source: SafetyLit: All (Unduplicated) - November 9, 2012 Category: Global & Universal Tags: Age: Adolescents Source Type: news

[Articles] Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study
After exclusion of copy-number variants, de-novo point mutations and small indels are associated with severe, sporadic non-syndromic intellectual disability, accounting for 45–55% of patients with high locus heterogeneity. Autosomal recessive inheritance seems to contribute little in the outbred population investigated. The large number of de-novo variants in known intellectual disability genes is only partially attributable to known non-specific phenotypes. Several patients did not meet the expected syndromic manifestation, suggesting a strong bias in present clinical syndrome descriptions.
Source: LANCET - November 9, 2012 Category: Journals (General) Authors: Anita Rauch, Dagmar Wieczorek, Elisabeth Graf, Thomas Wieland, Sabine Endele, Thomas Schwarzmayr, Beate Albrecht, Deborah Bartholdi, Jasmin Beygo, Nataliya Di Donato, Andreas Dufke, Kirsten Cremer, Maja Hempel, Denise Horn, Juliane Hoyer, Pascal Joset, Al Tags: Articles Source Type: research

[Comment] New mutations and sporadic intellectual disability
Intellectual disability is a worldwide health problem and causes a substantial socioeconomic burden, mostly for families. It is common, affecting around 1 in 75 children by the age of 10 years, and boys are affected more often than are girls (in a 1·6:1 ratio). About two-thirds of patients are mildly affected (intelligence quotient 50–70), and a third are severely affected (intelligence quotient <50). Intellectual disability is highly heterogeneous; genetic and environmental factors and chance events during development and early life all contribute.
Source: LANCET - November 9, 2012 Category: Journals (General) Authors: Jozef Gecz, Eric Haan Tags: Comment Source Type: research

Uganda: Am I At Risk for Stroke?
[New Vision]Fifteen million people worldwide suffer a stroke each year. Shockingly, 3 million women and 2.5 million men die as a direct result. In addition to this tragic loss of life, another 5 million people are left permanently disabled, placing a burden on family, community and society.
Source: AllAfrica News: Health and Medicine - November 9, 2012 Category: African Health Source Type: news

Outcome Prediction in Moderate and Severe Traumatic Brain Injury: A Focus on Computed Tomography Variables
Conclusions Outcome prediction in moderate and severe TBI might be improved using the models that were designed in this study. However, conventional demographic, clinical and CT variables proved insufficient to predict disability in surviving patients. The information that can be derived from our prediction rules is important for the selection and stratification of patients recruited into clinical TBI trials. Content Type Journal ArticleCategory Original ResearchPages 1-11DOI 10.1007/s12028-012-9795-9Authors Bram Jacobs, Department of Neurology (935), Radboud University Nijmegen Medical Centre (RUN...
Source: Neurocritical Care - November 9, 2012 Category: Neurology Tags: Neurocritical Care Source Type: research

“Stop the fraud!”: What is the effect of social deception priming on health professionals?
Organisations and systems that compensate others for disability due to musculoskeletal injury are attempting to guard against fraudulent claims. Health professionals working within these systems are frequently asked to conduct examinations to determine if a claimant’s symptoms are genuine and whether these symptoms reflect a true disability. Moreover, compensation/insurance organisations often make it clear that they expect vigilance on the part of all health professionals to help fight fraud which is a form of social deception. These types of messages concerning vigilance about the possibility of malingering and related...
Source: Pain - November 9, 2012 Category: Anesthesiology Authors: Thomas Hadjistavropoulos Tags: Commentaries Source Type: research

Specific Learning Disability and Its Newest Definition: Which Is Comprehensive? and Which Is Insufficient?
Abstract The American Psychiatric Association's proposed definition of specific learning disability ("specific learning disorder") for the DSM-5 reflects current thinking and best practice in learning disabilities. It continues the core conceptualization of learning disability (LD) as well as proposes identification criteria to supplant the discredited aptitude-achievement discrepancy formula. Improvements can be found along with long-standing and new controversies about the nature of LD. The proposed definition both provides a model of a currently acceptable definition and reflects critical issues in the operation...
Source: Journal of Learning Disabilities - November 9, 2012 Category: Disability Authors: Scanlon D Tags: J Learn Disabil Source Type: research

Rethinking ADHD and LD in DSM-5: Proposed Changes in Diagnostic Criteria.
This article first provides a brief synopsis of the DSM-5 administrative structure, procedures, and guiding principles to enhance understanding of how changes are made in the DSM. The next two sections (on attention-deficit/hyperactivity disorder and learning disorders, respectively) highlight the major concerns and controversies surrounding the DSM-IV diagnostic criteria for these two disorders and provide a rationale for the proposed changes to the criteria, along with a commentary on the empirical evidence on which the proposed changes were based. PMID: 23144062 [PubMed - as supplied by publisher]
Source: Journal of Learning Disabilities - November 9, 2012 Category: Disability Authors: Tannock R Tags: J Learn Disabil Source Type: research

Comorbidity of LD and ADHD: Implications of DSM-5 for Assessment and Treatment.
Abstract Attention-deficit/hyperactivity disorder (ADHD) and learning disability (LD) can co-occur for a significant minority of children with each disorder. A total of 17 studies (2001-2011) examining ADHD-LD comorbidity were reviewed, revealing a higher mean comorbidity rate (45.1%) than has been obtained previously. Higher comorbidity may be the result of including students with writing disorders, not just reading and/or math disabilities. Proposed DSM-5 criteria for both disorders will likely affect comorbidity rates; however, it is unclear whether such rates will increase or decrease. Regardless of the specifi...
Source: Journal of Learning Disabilities - November 9, 2012 Category: Disability Authors: Dupaul GJ, Gormley MJ, Laracy SD Tags: J Learn Disabil Source Type: research

Posterior dynamic stabilization in the treatment of degenerative lumbar stenosis: validity of its rationale.
Conclusions Based on radiological findings, the DIAM failed to show validity in terms of the rationale of indirect decompression, but it did restrict motion at the instrumented level without significant change in adjacent-segment ROM. The clinical condition of the patients, however, was improved, and improvement was maintained despite progressive loss of posterior disc height after surgery. PMID: 23140127 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery.Spine - November 9, 2012 Category: Neurosurgery Authors: Ha KY, Seo JY, Kwon SE, Son IN, Kim KW, Kim YH Tags: J Neurosurg Spine Source Type: research

Prospective study of disc repair with allogeneic chondrocytes Presented at the 2012 Joint Spine Section Meeting.
Conclusions This is a 12-month report of the clinical and radiographic results from a US IND study of cell-based therapy (juvenile chondrocytes) in the treatment of lumbar spondylosis with mechanical LBP. The results of this prospective cohort are promising and warrant further investigation with a prospective, randomized, double-blinded, placebo-controlled study design. Clinical trial registration no.: BB-IND 13985. PMID: 23140128 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery.Spine - November 9, 2012 Category: Neurosurgery Authors: Coric D, Pettine K, Sumich A, Boltes MO Tags: J Neurosurg Spine Source Type: research

Prospective randomized study of cervical arthroplasty and anterior cervical discectomy and fusion with long-term follow-up: results in 74 patients from a single site.
Conclusions Both cervical TDR and ACDF groups showed excellent clinical outcomes that were maintained over long-term follow-up. Both groups showed low index-level and adjacent-level reoperation rates. Both cervical TDR and ACDF appear to be viable options for the treatment of single-level cervical radiculopathy. PMID: 23140129 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery.Spine - November 9, 2012 Category: Neurosurgery Authors: Coric D, Kim PK, Clemente JD, Boltes MO, Nussbaum M, James S Tags: J Neurosurg Spine Source Type: research

The changing face of hepatitis C in the new era of direct-acting antivirals.
Abstract The approval of the first protease inhibitors as treatment for hepatitis C virus (HCV) infection is rapidly transforming the way patients with chronic hepatitis C are managed. Treatment regimens are moving to combinations given for shortened periods, excluding poorly tolerated subcutaneous interferon, and providing rates of cure exceeding 75%. The recognition of HCV infection as a systemic disease, not limited to producing liver damage, in which extrahepatic complications play a major role as the cause of morbidity and mortality, is prompting the treatment of a growing number of HCV-infected individuals. H...
Source: Antiviral Research - November 9, 2012 Category: Virology Authors: Soriano V, Labarga P, Fernández-Montero JV, Benito JM, Poveda E, Rallon N, Sánchez C, Vispo E, Barreiro P Tags: Antiviral Res Source Type: research

Does a falling level of activity predict disability development in community-dwelling elderly people?
Conclusion:Community-dwelling elderly people who report decreased physical activity have a higher risk to develop disability at one-year follow-up. PMID: 23144225 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - November 9, 2012 Category: Rehabilitation Authors: Vermeulen J, Spreeuwenberg MD, Daniëls R, Neyens JC, Van Rossum E, De Witte LP Tags: Clin Rehabil Source Type: research

Evaluating use and outcomes of mobility technology: A multiple stakeholder analysis.
Conclusions: The conceptual fit model and factors related to self-management of MT represent new knowledge and provide a framework for stakeholder-based evaluation of MT outcomes. Implications for MT assessment, service delivery, outcomes research, and interventions are discussed. PMID: 23137189 [PubMed - as supplied by publisher]
Source: Disability and Rehabilitation. Assistive Technology. - November 9, 2012 Category: Rehabilitation Authors: Hammel J, Southall K, Jutai J, Finlayson M, Kashindi G, Fok D Tags: Disabil Rehabil Assist Technol Source Type: research

Balance and walking involvement in facioscapulohumeral dystrophy: a pilot study on the effects of custom lower limb orthoses.
CONCLUSION: This pilot study shows that in FSHD patients' custom lower limb orthoses (foot-orthoses and ankle-foot-orthoses); evaluated by using a multidimensional approach, improve walking, balance and QoL. Clinical Rehabilitation Impact. These preliminary results suggest that custom lower limb orthoses could reduce the risk of falling with a positive effect on our patients' safety. Our results should encourage the scientific community to do efficacy study on this hot topic. PMID: 23138679 [PubMed - as supplied by publisher]
Source: European Journal of Physical and Rehabilitation Medicine - November 9, 2012 Category: Rehabilitation Authors: Aprile I, Bordieri C, Gilardi A, Lainieri Milazzo M, Russo G, De Santis F, Frusciante R, Iannaccone E, Erra C, Ricci E, Padua L Tags: Eur J Phys Rehabil Med Source Type: research

Diffusion changes predict cognitive and functional outcome. The LADIS study
Abstract Objective:To determine whether diffusion‐weighted imaging (DWI) abnormalities in normal‐appearing brain tissue (NABT) and in white matter hyperintensities (WMH) predict longitudinal cognitive decline and disability in older individuals independently of the concomitant MRI findings. Methods:A total of 340 Leukoaraiosis and Disability Study (LADIS) participants, aged 65‐84 years, underwent brain MRI including diffusion weighted imaging (DWI) at baseline. Neuropsychological and functional assessments were carried out at study entry and repeated annually over a 3‐year observational period. Linear mixed models ...
Source: Annals of Neurology - November 9, 2012 Category: Neurology Authors: Hanna Jokinen, Reinhold Schmidt, Stefan Ropele, Franz Fazekas, Alida A. Gouw, Frederik Barkhof, Philip Scheltens, Sofia Madureira, Ana Verdelho, José M. Ferro, Anders Wallin, Anna Poggesi, Domenico Inzitari, Leonardo Pantoni, Timo Erkinjuntti, Tags: Research Article Source Type: research

Kessler Foundation stroke expert receives $145,000 grant from Healthcare Foundation of New Jersey
(Kessler Foundation) A.M. Barrett, MD, director of stroke rehabilitation research at Kessler Foundation, was awarded a $145,000 grant by The Healthcare Foundation of New Jersey. The grant will enable Dr. Barrett, an expert in hidden disabilities after stroke, to extend her work in hidden disabilities to stroke survivors and health care providers in Newark, New Jersey. Dr. Barrett and her team study the hidden disability of functional vision known as spatial neglect.
Source: EurekAlert! - Medicine and Health - November 9, 2012 Category: Global & Universal Source Type: news

Disability and schizophrenia: a systematic review of experienced psychosocial difficulties
Conclusions: The present review illustrates the remarkably broad scope and diversity of psychosocial areas affected in schizophrenia and shows how these areas are interconnected and how they interact with contextual factors. The need for a shift in focus of schizophrenia research is suggested -- from an excessive reliance on global measures of psychopathology and disability for defining outcomes to the creation of profiles of specific PSDs that have a more direct bearing on the disabling experience and real-world functioning of patients and can serve to guide interventions and monitoring over time.
Source: BMC Psychiatry - Latest articles - November 9, 2012 Category: Psychiatry Authors: Piotr ¿witajMarta AnczewskaAnna ChrostekCarla SabariegoAlarcos CiezaJerome BickenbachSomnath Chatterji Source Type: research

Mechanisms of Obstructive Hydrocephalus in Wrp Null Mice [Cell Biology]
Hydrocephalus is the most common developmental disability and leading cause of brain surgery for children. Current treatments are limited to surgical intervention, as the factors that contribute to the initiation of hydrocephalus are poorly understood. Here, we describe the development of obstructive hydrocephalus in mice that are null for Wrp (Srgap3). Wrp is highly expressed in the ventricular stem cell niche, and it is a gene required for cytoskeletal organization and is associated with syndromic and psychiatric disorders in humans. During the postnatal period of progenitor cell expansion and ventricular wall remodeling...
Source: Journal of Biological Chemistry - November 9, 2012 Category: Chemistry Authors: Kim, I. H., Carlson, B. R., Heindel, C. C., Kim, H., Soderling, S. H. Tags: Neurobiology Source Type: research

Epigenetic contributions in the development of rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease, characterized by chronic inflammation of the joints with severe pain and swelling, joint damage and disability, which leads to joint destruction and loss of function. Despite extensive research efforts, the underlying cause for RA is still unknown and current therapies are more or less effective in controlling symptoms, but still fail to cure the disease. In recent years, epigenetic modifications turned out to strongly contribute to the development of RA by affecting diverse aspects of the disease and modifying gene expression levels and behavior of several cell types, mo...
Source: Arthritis Research and Therapy - November 9, 2012 Category: Rheumatology Authors: Kerstin KleinCaroline OspeltSteffen Gay Source Type: research

Kim Q Hall (ed.), Feminist Disability Studies
Source: Feminism - November 9, 2012 Category: Psychiatry & Psychology Authors: Haley, J. M. Tags: Book reviews Source Type: research

Breaking body hair boundaries: Classroom exercises for challenging social constructions of the body and sexuality
This article examines the social and pedagogical implications of an extra-credit assignment where I asked women to grow out their body hair and men to remove their body hair for 10 weeks in several upper-division women’s studies courses. Students’ response papers and weekly logs from 87 students over four semesters highlighted the social policing of gender and sexual identity, pervasive disgust and misinformation about body hair, raced and classed dimensions of students’ experiences, configurations of masculinity as agentic and powerful, and postexperiential reflections on challenging social norms. This a...
Source: Feminism - November 9, 2012 Category: Psychiatry & Psychology Authors: Fahs, B. Tags: Making a difference Source Type: research

Back Pain Self-Management: Benefits Big Enough to Matter?Back Pain Self-Management: Benefits Big Enough to Matter?
Self-management of low back pain is widely recommended but produces small effects on pain and disability, according to a new meta-analysis. Medscape Medical News
Source: Medscape Today Headlines - November 8, 2012 Category: Consumer Health News Tags: Rheumatology News Source Type: news