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Administration of Caffeic Acid Worsened Bone Mechanical Properties in Female RatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, high intake of caffeic acid may unfavorably affect the skeletal system.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Intestinal and Blood-Brain Barrier Permeability of Ginkgolides and Bilobalide: In Vitro and In Vivo ApproachesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study intestinal and blood-brain barrier (BBB) permeability of ginkgolides A, B, C, J and bilobalide, isolated from (Ginkgoaceae), was evaluated in Caco-2 and MDR1-MDCK cell monolayer models. The transport was examined for 2 hours in both absorptive and secretory directions. Quantitation was performed by UPLC‐MS. In the Caco-2 model, each compound (100 µM) displayed a pH-dependent transport in the absorptive direction. A low permeability of ginkgolides was observed across the MDR1-MDCK model in the absorptive direction. An efflux was observed for all compounds in both the models. The efflux ratio was m...
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Cytotoxicity of Natural Compounds Isolated from the Seeds of Garcinia afzeliiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240627AbstractThe new compounds guttiferone O () and 3-methoxycheffouxanthone () have been isolated from the seeds of Engl., together with nine known compounds: 2-hydroxy-1,7-dimethoxyxanthone (), smeathxanthone A (), 1,5-dihydroxyxanthone (), 1,6-dihydroxy-5-methoxyxanthone (), cheffouxanthone (), 1,3,5-trihydroxyxanthone (), smeathxanthone B (), isoxanthochymol () and guttiferone E (). Their structures were elucidated by means of 1D and 2D‐NMR techniques. All the isolates showed high cytotoxic activity and were found inactive when tested against HIV and influenza viruses.[...]© Georg...
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Minor Secondary Metabolic Products from the Stem Bark of Plumeria rubra Linn. Displaying Antimicrobial ActivitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240611AbstractFour new iridoids viz., plumeridoids A (), B (), and C () and epiplumeridoid C () were isolated from the stem bark of Linn. together with twenty-four known compounds viz., 1-(-hydroxyphenyl)propan-1-one, isoplumericin, plumericin, dihydroplumericin, allamcin, fulvoplumerin, allamandin, plumieride, --coumaric acid, 2,6-dimethoxy--benzoquinone, scopoletin, cycloart-25-en-3,24-diol, 2,4,6-trimethoxyaniline, ajunolic acid, ursolic acid, oleanolic acid, -amyrin acetate, betulinic acid, lupeol and its acetate, 2,3-dihydroxypropyl octacosanoate, glucoside of -sitosterol, and a mixture ...
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Effects of α-Asarone on the Glutamate Transporter EAAC1 in Xenopus OocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240613AbstractThe major excitatory neurotransmitter transporter EAAC1 in the mammalian central nervous system is considered a possible target for Chinese herbal medicine. Extracts of (Schott) were tested for their effects on EAAC1 activity. oocytes with heterologously expressed EAAC1 were used as the model system. Rate of glutamate uptake was determined by means of the isotopic tracer technique. Glutamate-induced current was recorded under a two-electrode voltage clamp. As a highly effective component, -asarone was identified. The rate of glutamate uptake was stimulated by 200 µM of -a...
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

The Corrected Structure of Rosmaridiphenol, a Bioactive Diterpene from Rosmarinus officinalisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240629AbstractFrom the aerial parts of a Chilean sample of L., a diterpene was isolated whose spectroscopic data and physical constants were coincident with that of rosmaridiphenol. However, careful examination of the spectroscopic data and chemical reactions led to a different structure, where the carbonyl function has to be placed at C-1 instead of C-20. The correct structure of rosmaridiphenol should therefore be changed to 11,12-dihydroxy-8,11,13-icetexatrien-1-one.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

New Phenolic Compounds of Acmella ciliataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240621AbstractThe phytochemical analysis of a butanolic fraction of Kunth. afforded a total of 15 hydrophilic compounds. Seven flavonol 3--glycosides were isolated, including two new natural products, quercetin-3--(3-acetyl--D-glucuronopyranoside) and quercetin-3--(2-acetyl--L-rhamnopyranosyl-(1 → 6)--D-glucopyranoside). Furthermore, a variety of caffeoylquinic acid derivatives could be identified using ESI‐MS and NMR-spectroscopy.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Green Tea Catechins: Inhibitors of Glycerol-3-Phosphate DehydrogenaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240623AbstractGreen tea catechins, especially (−)-epigallocatechin-3-gallate (EGCG), are known to regulate obesity and fat accumulation. We performed a kinetic analysis in a cell-free system to determine the mode of inhibition of glycerol-3-phosphate dehydrogenase (GPDH; EC 1.1.1.8) by EGCG. GPDH catalyzes the -nicotinamide adenine dinucleotide (NADH)-dependent reduction of dihydroxyacetone phosphate (DHAP) to yield glycerol-3-phosphate, which serves as one of the major precursors of triacylglycerols. We found that EGCG dose-dependently inhibited GPDH activity at a concentration of appr...
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

SERTRALINE HYDROCHLORIDEsolution, Concentrate [Aurobindo Pharma Limited]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 19, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 21, 2009 Category: Drugs & Pharmacology Source Type: organizations

US could ban caffeine-alcohol drinks within monthsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The US Food and Drug Administration has asked manufacturers of drinks that combine alcohol and caffeine to provide scientific evidence they are safe (Source: New Scientist - Drugs and Alcohol)
Source: New Scientist - Drugs and Alcohol - November 21, 2009 Category: Drugs & Pharmacology Source Type: journals

Semi-Synthesis of Dihydrochalcone Derivatives and Their in Vitro Antimicrobial ActivitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the semi-synthesis of dihydrochalcone derivatives and their antimicrobial activities. These compounds were prepared by modifying two naturally occurring antimicrobial dihydrochalcones, erioschalcones A and B, reported by us earlier. The structures of the compounds were assigned on the basis of spectroscopic evidence and by comparing their physical and spectroscopic data with those reported in the literature. All the compounds were subjected to antimicrobial assays against a panel of pathogenic microorganisms, including gram-positive and gram-negative bacteria, and fungi. The antimicrobial efficacies of this cla...
Source: Planta Medica - November 21, 2009 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Assessing the Impact of Efalizumab on Nail, Scalp and Palmoplantar Psoriasis and on Quality of Life: Results from a Multicentre, Open-label, Phase IIIb/IV TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This post-approval, open-label trial (n = 1266) assessed the efficacy of efalizumab, administered in accordance with the European label at that time, in patients with concomitant nail, scalp or palmoplantar psoriasis. Patients received subcutaneous efalizumab 1.0 mg/kg weekly for up to 20 weeks. By Week 12, an improvement from baseline of 50% or more was observed in 21.4% (181/844) of patients with nail psoriasis, 62.4% (718/1150) of patients with scalp psoriasis, and 51.4% (127/247) of patients with palmoplantar psoriasis. Quality of life improved throughout the trial, with a 50% median improvement in DLQI score after 12 ...
Source: Archives of Drug Information - November 21, 2009 Category: Drugs & Pharmacology Authors: Andreas Katsambas, Ketty Peris, Gino Vena, Peter Freidmann, Gottfried Wozel, Esteban Daudén, Daiana Licu, Mauro Placchi, Michel De La Brassinne Source Type: journals

Joint Commission updates National Patient Safety Goals for 2010.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19923302 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: Traynor K Tags: Am J Health Syst Pharm Source Type: journals

Ofatumumab approved for advanced CLL.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19923303 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: Traynor K Tags: Am J Health Syst Pharm Source Type: journals

Health system views pharmacist as vital to coordinated care.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19923304 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: Thompson CA Tags: Am J Health Syst Pharm Source Type: journals

Some unused narcotics should go down the drain, FDA says.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19923305 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: Traynor K Tags: Am J Health Syst Pharm Source Type: journals

International hospital pharmacy section reorganizes to promote Basel Statements.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19923306 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: Thompson CA Tags: Am J Health Syst Pharm Source Type: journals

Development of a methadone order form for inpatients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19923307 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: McMillian WD, Gencarelli SC Tags: Am J Health Syst Pharm Source Type: journals

Leading from a staff or clinical position.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19923308 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: White SJ Tags: Am J Health Syst Pharm Source Type: journals

Alert fatigue.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19923309 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: Cash JJ Tags: Am J Health Syst Pharm Source Type: journals

The dilemma of establishing effective pharmacy staffing levels.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19923310 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: Shane R, Gouveia W Tags: Am J Health Syst Pharm Source Type: journals

Clinical and economic value of screening for Kras mutations as predictors of response to epidermal growth factor receptor inhibitors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Mutations in the Kras oncogene are associated with a poor response to EGFR inhibitor therapy in metastatic colorectal cancer. Implementing routine Kras screening and limiting the use of EGFR inhibitors to patients with wild-type (not mutated) Kras may have the potential for cost savings. PMID: 19923311 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: Mancl EE, Kolesar JM, Vermeulen LC Tags: Am J Health Syst Pharm Source Type: journals

Review of recent evidence: Potential interaction between clopidogrel and proton pump inhibitors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Although data are limited, observational studies and prospective trials involving surrogate markers of platelet reactivity suggest a clinically significant interaction between clopidogrel and PPIs. Until further studies are completed to delineate the specifics of the interaction between clopidogrel and PPIs, the risks and benefits of concomitant treatment should be carefully weighed to determine the most appropriate treatment for each individual patient. PMID: 19923312 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: Last EJ, Sheehan AH Tags: Am J Health Syst Pharm Source Type: journals

Elevated International Normalized Ratio associated with concurrent use of sorafenib and warfarin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A 70-year-old man diagnosed with hepatocellular carcinoma experienced an increase in INR values after the addition of sorafenib to his warfarin regimen. PMID: 19923313 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: Moretti LV, Montalvo RO Tags: Am J Health Syst Pharm Source Type: journals

Medication reconciliation at an academic medical center: Implementation of a comprehensive program from admission to discharge.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A pharmacy-driven multidisciplinary admission history and medication reconciliation process has reduced medication errors in an academic medical center. PMID: 19923314 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: Murphy EM, Oxencis CJ, Klauck JA, Meyer DA, Zimmerman JM Tags: Am J Health Syst Pharm Source Type: journals

Synthesis and biological activities of new substituted thiazoline-quinoline derivatives.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
5-Acyl-8-hydroxyquinoline-2-(3'-substituted-4'-aryl-2,3-dihydrothiazol-2'-ylidene)hydrazones, 5a-e to 10a-c, were prepared by the reaction of appropriate 5-acyl-8-hydroxyquinoline-4-substituted thiosemicarbazones 3a-e and phenacyl bromides 4a-e. Structures of the new compounds were verified on the basis of spectral and elemental analyses. Twenty-eight new compounds were tested for their possible antimicrobial activities. Most of the tested compounds showed weak to moderate antibacterial activity against most of the bacterial strains used in comparison with gatifloxacin as a reference drug. The test compounds showed wea...
Source: Acta Pharmaceutica - November 20, 2009 Category: Drugs & Pharmacology Authors: Hussein MA, Kafafy AH, Abdel-Moty SG, Abou-Ghadir OM Tags: Acta Pharm Source Type: journals

Formulation and evaluation of monolithic matrix polymer films for transdermal delivery of nitrendipine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the present work was to develop a suitable transdermal drug delivery system for nitrendipine. Polymeric films of nitrendipine were prepared by the film casting technique (glass ring) on mercury substrate. They were evaluated for physicochemical parameters, in vitro release and ex vivo permeation (heat separated human epidermis). Release of the drug from the films followed anomalous transport (0.5 < n < 1).Polymeric combination containing Eudragit RL 100:PVP K 30 in a 4:6 ratio showed the best results. Maximum drug release and skin permeability coefficient in 48 h were 85.8% and 0.0142 cm h-1, respect...
Source: Acta Pharmaceutica - November 20, 2009 Category: Drugs & Pharmacology Authors: Mittal A, Sara UV, Ali A Tags: Acta Pharm Source Type: journals

Permeation of losartan across human respiratory epithelium: An in vitro study with Calu-3 cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The potential for nasal delivery of losartan, a drug with poor oral bioavailability, was investigated using Calu-3 cells. Epithelial permeation of the drug with or without dimethyl-beta-cyclodextrin (DM-beta-CD) and glycocholate was investigated. Possible transport mechanism of the compound and epithelial mucosal tolerance were screened. Reversibility of epithelial membrane perturbation was also investigated by measuring transepithelial electrical resistance (TEER) recovery over a 24-h period following drug formulation exposure. The permeability coefficient of losartan was 1.3 +/- 0.5 x 10-6 cm s-1. This flux was not s...
Source: Acta Pharmaceutica - November 20, 2009 Category: Drugs & Pharmacology Authors: Amoako-Tuffour M, Yeung PK, Agu RU Tags: Acta Pharm Source Type: journals

A new approach to the spectrophotometric determination of metronidazole and tinidazole using p-dimethylaminobenzaldehyde.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new approach to the spectrophotometric determination of metronidazole (MZ) and tinidazole (TZ) has been developed. The procedure involves coupling of diazotized nitroimidazoles with p-dimethylaminobenzaldehyde (DMAB) to form a greenish-yellow solution. Optimal temperature and time were 0 degrees C (iced) and 3 minutes for diazotization and 30 degrees C and 2 minutes for coupling for both MZ and TZ. Coloured adducts of MZ and TZ showed shoulders at 406 nm and 404 nm, respectively, which were selected as analytical wavelengths. The reaction with p-DMAB occurred in a 1:1 mole ratio. Beer's law was obeyed within the 4.8-...
Source: Acta Pharmaceutica - November 20, 2009 Category: Drugs & Pharmacology Authors: Adegoke OA, Umoh OE Tags: Acta Pharm Source Type: journals

Development of a radiolabeled beta-human chorionic gonadotropin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
beta-Human chorionic gonadotropin (beta-hCG) was successively labeled with [67Ga]-gallium chloride after conjugation with freshly prepared diethylenetriaminepentaacetic acid dianhydride (ccDTPA). After solid phase purification of the radiolabeled hormone, high performance liquid chromatography showed radiochemical purity higher than 95 % under optimized conditions (specific activity = 22-23 TBq mM-1, labeling efficiency 80 %). Preliminary in vivo studies (ID g-1, %) in male wild-type rats showed marked gonadal uptake of the tracer after 240 minutes in agreement with the biodistribution studies and reported beta-hCG rec...
Source: Acta Pharmaceutica - November 20, 2009 Category: Drugs & Pharmacology Authors: Jalilian AR, Khoshdel MR, Garousi J, Yousefnia H, Hosseini MA, Rajabifar S, Sardari D Tags: Acta Pharm Source Type: journals

Synthesis, anticancer and cytostatic activity of some 6H-indolo[2,3-b]quinoxalines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Various 6-aralkyl-9-substituted-6H-indolo[2,3-b]quinoxalines were synthesized by reaction of 1,5-disubstituted 2,3-dioxo-2,3-dihydroindole and orthophenylene diamine. Appreciable anticancer activity of compounds 5b, 5d, 5g and 5l at various cell lines among 59 human tumor cell panels was observed. All the synthesized compounds were evaluated for cytostatic activity against human Molt 4/C8 and CEM T-lymphocytes as well as for murine L1210 leukemia cells. Compound 5h exhibited an I C50 of 23 mumol L-1 against Molt 4/C8 and 38 mumol L-1 against CEM compared to melphalan 3.2 mumol L-1 and 2.5 mumol L-1, respectively. The I...
Source: Acta Pharmaceutica - November 20, 2009 Category: Drugs & Pharmacology Authors: Karki SS, Hazare R, Kumar S, Bhadauria VS, Balzarini J, De Clercq E Tags: Acta Pharm Source Type: journals

Synthesis and preliminary screening of benzothiazol-2-yl thiadiazole derivatives for anticonvulsant activity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Various N-(5-chloro-6-substituted-benzothiazol-2-yl)-N'-(substituted phenyl)-[1,3,4]thiadiazole-2,5-diamines (5a-t) were designed and synthesized starting from substituted acetophenones. Structures of all the compounds were confirmed on the basis of spectral and elemental analyses. All the newly synthesized compounds were screened for their anticonvulsant activity and were compared with the standard drug phenytoin sodium. Interestingly, all the compounds showed protections against seizures in the range 50-100% indicative of the promising nature of the compounds against seizure spread. Compounds 5b and 5c showed complet...
Source: Acta Pharmaceutica - November 20, 2009 Category: Drugs & Pharmacology Authors: Siddiqui N, Rana A, Khan SA, Haque SE, Arshad MF, Ahmed S, Ahsan W Tags: Acta Pharm Source Type: journals

Physicochemical characterization of solid dispersion systems of tadalafil with poloxamer 407.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dissolution behaviour of a poorly water-soluble drug, tadalafil, from its solid dispersion systems with poloxamer 407 has been investigated. Solid dispersion systems of tadalafil were prepared with poloxamer 407 in 1:0.5, 1:1.5 and 1:2.5 ratios using the melting method. Characterization of binary systems with FTIR and XRPD studies demonstrated the presence of strong hydrogen bonding interactions, a significant decrease in crystallinity and the possibility of existence of amorphous entities of the drug. In the binary systems tested, 1:0.5 proportion of tadalafil/poloxamer 407 showed rapid dissolution of tadalafil (DE30 ...
Source: Acta Pharmaceutica - November 20, 2009 Category: Drugs & Pharmacology Authors: Vyas V, Sancheti P, Karekar P, Shah M, Pore Y Tags: Acta Pharm Source Type: journals

Chemical composition of endemic Centaurea austro-anatolica and studies of its antimicrobial activity against multi-resistant bacteria.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hexane, chloroform, ethyl acetate and ethanolic extracts of the aerial parts of Centaurea austro-anatolica Hub.-Mor. (Asteraceae) were evaluated against microorganisms, including multiresistant bacteria, using a paper disc diffusion method. The chloroform extract exhibited significant antibacterial activity toward all bacteria tested. The chemical composition of the chloroform extract was determined by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The major compounds of the extract were caryophyllene oxide (21.32 %), spathulenol (10.86 %), n-tricosanol (9.58 %) and geranyl isovalerate (8.71 ...
Source: Acta Pharmaceutica - November 20, 2009 Category: Drugs & Pharmacology Authors: Ugur A, Sarac N, Ceylan O, Duru ME Tags: Acta Pharm Source Type: journals

An improved procedure for synthesis of some new 1,3-diaryl-2-propen-1-ones using PEG-400 as a recyclable solvent and their antimicrobial evaluation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A simple and convenient route is described for the synthesis of novel hetero 1,3-diaryl-2-propen-1-ones (chalcones) by using recyclable PEG-400 as an alternative reaction solvent. The reaction is clean with excellent yield, shorter reaction time and reduces the use of volatile organic compounds (VOCs). All the synthesized compounds were evaluated for their antimicrobial activities against several pathogenic representatives. PMID: 19919936 [PubMed - as supplied by publisher] (Source: Acta Pharmaceutica)
Source: Acta Pharmaceutica - November 20, 2009 Category: Drugs & Pharmacology Authors: Dawane BS, Konda SG, Shaikh BM, Bhosale RB Tags: Acta Pharm Source Type: journals

Pharmacokinetic Comparison of a Delayed-Release Combination of Doxylamine Succinate and Pyridoxine Hydrocholoride (Diclectin) and Oral Solutions of These Drugs in Healthy Women of Childbearing Age.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionThe pharmacokinetic profile of Diclectin® well explains its documented delayed efficacy.Keywords: Nausea and vomiting of pregnancy; pregnancy; pharmacokinetics; doxylamine succinate; pyridoxine chloride; pyridoxal, pyridoxamine, pyridoxal-5 phosphate  PMID: 19923636 [PubMed - as supplied by publisher] (Source: The Canadian Journal of Clinical Pharmacology)
Source: The Canadian Journal of Clinical Pharmacology - November 20, 2009 Category: Drugs & Pharmacology Authors: Nulman I, Koren G Tags: Can J Clin Pharmacol Source Type: journals

Herbs, Vitamins and Minerals in the Treatment of Premenstrual Syndrome: A Systematic Review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Only calcium had good quality evidence to support its use in PMS. Further research is needed, using RCTs of adequate length, sufficient sample size, well-characterized products and measuring the effect on severity of individual PMS symptoms. PMID: 19923637 [PubMed - as supplied by publisher] (Source: The Canadian Journal of Clinical Pharmacology)
Source: The Canadian Journal of Clinical Pharmacology - November 20, 2009 Category: Drugs & Pharmacology Authors: Whelan AM, Jurgens TM, Naylor H Tags: Can J Clin Pharmacol Source Type: journals

Sleep Medication Use in Canadian Seniors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionsThis study provides important new information on the use of sleep medication by older Canadians. Overall sleep medication use and proportion of sleep medication prescribed are separate parameters with potentially different distributions, e.g., Quebec showed the same amount of sleep medication use as elsewhere, but a much higher proportion of it was prescribed.Key words: Sleep medication; comorbidity; elderly; quality of sleep  PMID: 19923638 [PubMed - as supplied by publisher] (Source: The Canadian Journal of Clinical Pharmacology)
Source: The Canadian Journal of Clinical Pharmacology - November 20, 2009 Category: Drugs & Pharmacology Authors: Neutel CI, Patten SB Tags: Can J Clin Pharmacol Source Type: journals

FDA Warns of Bacteria in Nasal SprayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
WASHINGTON (MedPage Today) -- Several lots of Vicks Sinex nasal spray have been recalled because of bacteria found in the solution during a quality control inspection, the FDA announced. (Source: MedPage Today Product Alert)
Source: MedPage Today Product Alert - November 20, 2009 Category: Drugs & Pharmacology Source Type: news

Tories call for NHS pricing reformEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Shadow Health Secretary Andrew Lansley has said NHS drugs should have a "value based pricing" system to prevent patients being denied medicines after a row broke out over advanced liver cancer treatment (Source: Pharmacy Europe)
Source: Pharmacy Europe - November 20, 2009 Category: Drugs & Pharmacology Source Type: news

Fake drugs "are top public concern"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fake drugs and medicines are becoming a top concern among members of the public, who want to see stiff prison sentences introduced for counterfeiters (Source: Pharmacy Europe)
Source: Pharmacy Europe - November 20, 2009 Category: Drugs & Pharmacology Source Type: news

New gastric cancer drug approvedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A drug to treat the seventh most common cancer in Europe has been approved by the European Medicines Agency (EMEA) (Source: Pharmacy Europe)
Source: Pharmacy Europe - November 20, 2009 Category: Drugs & Pharmacology Source Type: news

Results from study with Xarelto to be presented at ASH 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
EINSTEIN-extension trial demonstrates Xarelto's significant benefit in the secondary prevention of recurrent symptomatic VTE (Source: Pharmacy Europe)
Source: Pharmacy Europe - November 20, 2009 Category: Drugs & Pharmacology Source Type: news

FDA Approves Intravenous Formulation Of Pfizer's Revatio (Sildenafil) For The Treatment Of Pulmonary Arterial HypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Revatio is the Only Treatment in Its Class with Both Oral and Intravenous Formulations NEW YORK--(BUSINESS WIRE)--Nov 20, 2009 - Pfizer announced today that the U.S. Food and Drug Administration (FDA) has approved Revatio (sildenafil) Injection,... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - November 20, 2009 Category: Drugs & Pharmacology Source Type: news

New Chemical May Play Key Role In Hospital Superbugs' Battle, UKEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new chemical compound that mimics the body's ability to fight bacteria could help target hospital-acquired infections such as MRSA and C.difficile. The compound, which could be added to detergents or used as a coating for hospital equipment, is able to trap and release the gas nitric oxide - which is also produced by our own immune systems to kill bugs. (Source: MRSA / Drug Resistance News From Medical News Today)
Source: MRSA / Drug Resistance News From Medical News Today - November 20, 2009 Category: Drugs & Pharmacology Tags: MRSA / Drug Resistance Source Type: news

FELODIPINEtablet, Film Coated, Extended Release [Mylan Pharmaceuticals Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 20, 2009 Category: Drugs & Pharmacology Source Type: organizations

XYLOCAINE (Lidocaine Hydrochloride) Solution [APP Pharmaceuticals, LLC]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 20, 2009 Category: Drugs & Pharmacology Source Type: organizations

CYCLOSPORINEsolution [IVAX Pharmaceuticals, Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 20, 2009 Category: Drugs & Pharmacology Source Type: organizations

VETSCRIPTION SURE SHOT 2X (Pyrantel Pamoate) Liquid [Sergeant'S Pet Care Products, Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 20, 2009 Category: Drugs & Pharmacology Source Type: organizations

JOLESSA (Levonorgestrel / Ethinyl Estradiol) Kit [Barr Laboratories, Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 20, 2009 Category: Drugs & Pharmacology Source Type: organizations