Cytotoxic activity of diterpenes and extracts of juniperus brevifolia
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Planta MedDOI: 10.1055/s-2008-1074529AbstractThe hexane, dichloromethane, acetone and ethanol extracts of the leaves, bark and wood of were subjected to screening against human tumour cells lines from the cervix (HeLa) and larynx (Hep-2) in two different stages of the cell cycle. The dichloromethane and the chloroform-soluble portions of the acetone extracts of the leaves were active against both tumour cell lines. Chemical investigation of one of the most active extracts (dichloromethane extract from leaves) by preparative chromatography afforded compounds . Among these, compounds were isolated for the first time from the...
Source: Planta Medica - May 17, 2008 Category: Drugs & Pharmacology Source Type: journals
Anticomplementary activity of triterpenoids from the whole plant of aceriphyllum rossii against the classical pathway
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Planta MedDOI: 10.1055/s-2008-1074534AbstractTo provide a better understanding of the anti-complement activity of triterpenoids, seven unusual pentacyclic triterpenoids bearing a carboxyl group at C-27 were evaluated for their anticomplement activities against the classical pathway of the complement system. The triterpenoids were isolated from the whole plant of of the family Saxifragaceae and were determined to be 3α,23-isopropylidenedioxyolean-12-en-27-oic acid (), 3-oxoolean-12-en-27-oic acid (), 3α-hydroxyolean-12-en-27-oic acid (), β-peltoboykinolic acid (), 3α,23-diacetoxyolean-12-en-27-oic acid (...
Source: Planta Medica - May 17, 2008 Category: Drugs & Pharmacology Source Type: journals
Glucuronidated metabolites of the flavonoid quercetin do not auto-oxidise, do not generate free radicals and do not decrease nitric oxide bioavailability
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Planta MedDOI: 10.1055/s-2008-1074525AbstractQuercetin, the most abundant flavonoid in the diet, reduces blood pressure and restores endothelial dysfunction in hypertensive animals. However, quercetin (as the aglycone) is usually not present in plasma, but it is rapidly metabolised during absorption by methylation, glucuronidation and sulfation. Depending on the experimental conditions, quercetin can show anti-oxidant or pro-oxidant effects. We have analysed the pro-oxidant effects of quercetin and its methylated (3-methylquercetin or isorhamnetin), sulfated (quercetin 3′-sulfate), glucuronidated (quercetin 3-glucuro...
Source: Planta Medica - May 17, 2008 Category: Drugs & Pharmacology Source Type: journals
Madecassoside isolated from centella asiatica herbs facilitates burn wound healing in mice
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Planta MedDOI: 10.1055/s-2008-1074533AbstractThe current study was designed to investigate the effect of madecassoside, the major triterpene in , on burn wound healing and its possible mechanism of action. An oral administration of madecassoside (6, 12, 24 mg/kg) facilitated wound closure in a time-dependent manner and reached its peak effect, nearly completely wound closure, on day 20 in the group receiving the highest dose of 24 mg/kg of madecassoside. Further histopathological analysis revealed that madecassoside alleviated infiltration of inflammatory cells as well as enhanced epithelisation resulting from dermal proli...
Source: Planta Medica - May 17, 2008 Category: Drugs & Pharmacology Source Type: journals
Growth inhibition of a spectrum of bacterial and fungal pathogens by sulforaphane, an isothiocyanate product found in broccoli and other cruciferous vegetables
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Planta MedDOI: 10.1055/s-2008-1074520AbstractIn addition to its documented antitumor effects, previous and infectivity experiments have shown that sulforaphane (SFN), an isothiocyanate compound found abundantly in broccoli and other cruciferous vegetables, inhibits the growth of the bacterial pathogen No recent evidence exists, however, on the possible microbial activity of SFN against a broader range of microorganisms, including those that may develop resistance to conventional antibiotics. The aim of this study was to determine the susceptibility patterns of SFN against a wide variety of bacterial and fungal pathogens. S...
Source: Planta Medica - May 17, 2008 Category: Drugs & Pharmacology Source Type: journals
Chemotaxonomic study of medicinal taxus species with fingerprint and multivariate analysis
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Planta MedDOI: 10.1055/s-2008-1074531AbstractSpecies delimitation in has been controversial and it is very difficult to distinguish yew materials by their morphological characters. In this paper, a valid HPLC fingerprinting method coupled with multivariate analysis was used to define a framework for species identification and classification. Fingerprint-based similarity was employed for a chemotaxonomic study by hierarchical clustering analysis (HCA) and principal component analysis (PCA). Based on the PCA loadings, twelve chemical constituents were selected as chemotaxonomic markers which can be used to establish a more p...
Source: Planta Medica - May 17, 2008 Category: Drugs & Pharmacology Source Type: journals
Zaleplon: hallucinations and illusions: case report.
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Page: 35 (Source: Reactions Weekly)
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Venlafaxine overdose: fatal heart arrest: 2 case reports.
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Page: 34 (Source: Reactions Weekly)
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Vitamin d analogues overdose: hypercalcaemia and nephrocalcinosis in infants, treated with alendronic acid: 2 case reports.
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Page: 34 (Source: Reactions Weekly)
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Vitamin d analogues abuse: hypercalcaemia and renal failure: case report.
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Page: 34 (Source: Reactions Weekly)
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Venlafaxine: anticholinergic-type symptoms following accidental administration: case report.
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Page: 33 (Source: Reactions Weekly)
Source: Reactions Weekly - May 17, 2008 Category: Drugs & Pharmacology Tags: HTML Source Type: journals
Venlafaxine: increased libido and spontaneous orgasms: 3 case reports.
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Page: 33 (Source: Reactions Weekly)
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Valproic acid: haematological disorders: case report.
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Page: 33 (Source: Reactions Weekly)
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Trastuzumab: first report of ectopic pregnancy: case report.
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Page: 32 (Source: Reactions Weekly)
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Sulpiride: hyperprolactinaemia and sexual function disorders, treated with aripiprazole: case report.
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Page: 32 (Source: Reactions Weekly)
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Tioguanine: portal hypertension, variceal haemorrhage and nodular hyperplasia: case report.
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Page: 32 (Source: Reactions Weekly)
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Sirolimus: kidney disorders: case report.
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Page: 31 (Source: Reactions Weekly)
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Squaric acid dibutylester: contact dermatitis leading to dle exacerbation: case report.
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Page: 31 (Source: Reactions Weekly)
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Spiramycin/metronidazole: anaphylaxis (first report with metronidazole): case report.
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Page: 31 (Source: Reactions Weekly)
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Solanaceous alkaloids: central diabetes insipidus: case report.
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Page: 31 (Source: Reactions Weekly)
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Pyridoxine: severe sensorimotor neuropathy following excessive use in an elderly patient: case report.
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Page: 30 (Source: Reactions Weekly)
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Salbutamol: first report of anaphylaxis: case report.
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Page: 30 (Source: Reactions Weekly)
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Sertraline: serotonin syndrome in an elderly patient: case report.
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Page: 30 (Source: Reactions Weekly)
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Risperidone: tic treated with aripiprazole: case report.
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Page: 30 (Source: Reactions Weekly)
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Pregabalin: first report of neutropenia: case report.
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Page: 29 (Source: Reactions Weekly)
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Prednisone: exacerbation of kaposi's sarcoma: case report.
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Page: 29 (Source: Reactions Weekly)
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Potassium bromide: bromoderma in a child: case report.
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Page: 29 (Source: Reactions Weekly)
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Pioglitazone: mitral valve regurgitation: case report.
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Page: 28 (Source: Reactions Weekly)
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Peginterferon-[alpha]-2a: maculopapular eruption: case report.
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Page: 28 (Source: Reactions Weekly)
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Oxycodone: first report of cholestatic hepatitis: case report.
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Page: 27 (Source: Reactions Weekly)
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Opioid analgesics: apnoea, bradycardia and decreased respiratory rates in paediatric patients: 3 case reports.
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Page: 27 (Source: Reactions Weekly)
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Pamidronic acid/zoledronic acid: osteonecrosis of the jaw: 8 case reports.
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Page: 27 (Source: Reactions Weekly)
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Orlistat: calcium oxalate crystalluria and acute tubular necrosis?: 2 case reports.
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Page: 27 (Source: Reactions Weekly)
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Nevirapine overdose: neutropenia and hyperlactataemia in a neonate: case report.
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Page: 26 (Source: Reactions Weekly)
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Morphine overdose: miosis, consciousness disorders and respiratory insufficiency in an elderly patient: case report.
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Page: 26 (Source: Reactions Weekly)
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Modafinil: short manic-like episodes: case report.
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Page: 26 (Source: Reactions Weekly)
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Mivacurium chloride: apnoea in a patient with cholinesterase ii deficiency, treated by plasma transfusion: case report.
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Page: 25 (Source: Reactions Weekly)
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Minoxidil: stevens-johnson syndrome: case report.
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Page: 25 (Source: Reactions Weekly)
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Mifepristone/misoprostol: first report of mobius syndrome in a neonate following in utero exposure: case report.
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Page: 25 (Source: Reactions Weekly)
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Magnesium oxide abuse: quadriparesis (first report), secondary to hypermagnesaemia: case report.
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Page: 24 (Source: Reactions Weekly)
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Mefloquine: psychotic mania: case report.
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Page: 24 (Source: Reactions Weekly)
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Meglumine antimonate: eczema and anaphylaxis following topical and intramuscular administration: case report.
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Page: 24 (Source: Reactions Weekly)
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Metoprolol/paroxetine interaction: complete atrioventricular block: case report.
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Page: 24 (Source: Reactions Weekly)
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Lithium/tamoxifen: depression in a patient with bipolar disorder: case report.
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Page: 23 (Source: Reactions Weekly)
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Lithium/ziprasidone interaction: hyperprolactinaemia and galactorrhoea: case report.
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Page: 23 (Source: Reactions Weekly)
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Lithium/antiepileptic drugs/naproxen/aripiprazole/memantine interaction: cognition disorders: case report.
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Page: 23 (Source: Reactions Weekly)
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Levofloxacin/norfloxacin: recall urticaria: 2 case reports.
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Page: 22 (Source: Reactions Weekly)
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Lithium: lingual thyroid enlargement: case report.
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Page: 22 (Source: Reactions Weekly)
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Isoflavones: pseudolymphoma: case report.
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Page: 22 (Source: Reactions Weekly)
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Lithium: hypercalcaemia and hypoparathyroidism leading to delirium: case report.
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Page: 22 (Source: Reactions Weekly)
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