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This page shows you the most recent publications within this specialty of the MedWorm directory.

Cytotoxic, Anti‐Tumour and Anti‐Metastatic Activity of Two New Polyacetylenes Isolated from Vernonia scorpioides (Lam.) Pers
In conclusion, in vitro and in vivo anticancer activity of polyacetylene 1 was consistently observed and involved the induction of apoptosis by the activation of caspase‐3. The anticancer activity demonstrated by polyacetylene 1, together with the absence of preliminary toxicological effects, represents a new and interesting option for the management of neoplastic disease. This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - June 15, 2013 Category: Drugs & Pharmacology Authors: Juliana Bagatini Klein, Alexandre Eduardo Nowill, Gilberto Carlos Franchi Junior, Maique Weber Biavatti, Nara Lins Meira Quintão, Rilton Alves Freitas Tags: Original Article Source Type: research

Anatomy of vegetative organs of Scutellaria agrestis, a medicinal plant cultivated by riverine populations of the Brazilian Amazon
This study aimed to characterize the anatomy and to make histochemical analysis on vegetative organs of S. agrestis. Samples of the leaf, stem and root were collected from five plants cultivated by the communities located in the Solimões river, Amazon. These samples were fixed and prepared following standard techniques for scanning electron microscopy and for light microscopy. Histochemical tests were carried out on sections to detect the main classes of compounds present in the secretion. Numerous glandular trichomes are seen in both leaf and stem of S. agrestis. The leaves are amphi-hypostomatics and show dorsiventral m...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Pharmacognostic and phytochemical studies on Ayurvedic drugs Ativisha and Musta
The study include the establishment of pharmacognostic and phytochemical characters of Ativisha (Aconitum heterophyllum Wall. ex Royle, Ranunculaceae) and to compare them with its substitutes, Cyperus rotundus L. (Musta), C. scariosus R. Br., Cyperaceae, and Cryptocoryne spiralis (Retz.) Fisch. ex Wydler, Araceae (Country Ativisha). Morphology of the four species was compared in authentic samples collected from the field. We performed histological, histochemical, phytochemical tests, using standard protocols. HPLC studies were done on aqueous extracts of samples in a Shimadzu HPLC system and the peaks were observed at 254 ...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Plinia edulis - leaf architecture and scanning electron micrographs
Many species of Myrtaceae, including Plinia edulis (Vell.) Sobral (cambucá), have pharmacological properties and are used as hypoglycemiants and therapeutic agents against stomach problems and throat infections. Samples were collected from Tijuca Forest in Rio de Janeiro, and the morpho-anatomical data were compared with other specimens obtained from Trindade, Paraty, found in the literature. Variations in leaf anatomy were observed, and the possible causes for these effects are discussed. The plant material collected from Tijuca Forest was analyzed using scanning electron and optical microscopy. Histochemical tests were ...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Light intensity on growth, leaf micromorphology and essential oil production of Ocimum gratissimum
Light conditions can promote the growth and development of plants and contribute to increase the essential oil production of commercially cultivated medicinal and aromatic species. In view of the great importance of Ocimum gratissimum L., Lamiaceae, as an aromatic plant, the objective of this work was to determine the effect of light intensities (approximately 4, 7, 11 and 20 mol m-2 d-1) on growth, foliar micromorphology, essential oil content, yield and chemical composition of O. gratissimum. Biomass production of different organs, root:shoot ratio and leaf mass per area were found to linearly increase with increased lig...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Pyrrolizidine alkaloids in medicinal tea of Ageratum conyzoides
It is now widely-recognized that the view that herbal remedies have no adverse effects and/or toxicity is incorrect; some traditionally-used plants can present toxicity. The well-established popular use of Ageratum conyzoides has led to its inclusion in a category of medicinal crude drugs created by the Brazilian Health Surveillance Agency. Ageratum belongs to the Eupatorieae tribe, Asteraceae, and is described as containing toxic pyrrolizidine alkaloids. Aqueous extracts of Ageratum conyzoides L. harvested in Brazil (commercial, flowering and non-flowering samples) were prepared according to the prescribed method and anal...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Chemical variability in the essential oils from leaves of Syzygium jambos
Syzygium jambos (L.) Alston, Myrtaceae, occurs in tropical regions and is a widespread medicinal plant used to treat several diseases, such as hemorrhage, dysentery, diabetes, inflammation, diabetes and gastrointestinal disorders. Leaf essential oils of ten specimens of S. jambos collected from two localities of Central Brazilian Cerrado were investigated by GC-MS. Soil and foliar nutrients were analyzed to determine the mineral compositions. The aims of this study was to evaluate the influence of environmental factors on chemical composition of leaf essential oils of S. jambos. Studies on the influence of environmental fa...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Isolation, structural identification and cytotoxic activity of hexanic extract, cyperenoic acid, and jatrophone terpenes from Jatropha ribifolia roots
The cytotoxicity of a hexanic fraction produced from the ethanolic crude extract, obtained from Jatropha ribifolia (Pohl) Baill, Euphorbiaceae, roots was evaluated against ten human cancer cell lines (MCF-7, NCI-ADR/RES, OVCAR-3, PC-3, HT-29, NCI-H460,786-O, UACC-62, K-562, U251) compared with doxorrubicine as positive control. Compounds jatrophone and cyperenoic acid were isolated from the hexanic extract and characterized by spectroscopic techniques (NMR of ¹H, 13C and IR). The in vitro antiproliferative activity of jatrophone showed selectivity in a concentration dependent way with Total Inhibition growth of: glioma 0....
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Antileishmanial activity of amides from Piper amalago and synthetic analogs
Two natural amides isolated from the chloroform extract of Piper amalago L., Piperaceae, leaves, a hydrogenated derivative and seven synthetic analogs were tested against the promastigote and intracellular amastigote forms of Leishmania amazonensis. The antileishmanial activity was evaluated in terms of growth inhibitory concentration for 50% of protozoa (IC50). The cytotoxicity toward the J774A1 macrophages was evaluated in terms of the cytotoxic concentrations for 50% of macrophages (CC50). The ability to induce nitric oxide production was also investigated for all compounds. The saturated amide 7-(1,3-benzodioxol-5-yl)-...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

The catechin flavonoid reduces proliferation and induces apoptosis of murine lymphoma cells LB02 through modulation of antiapoptotic proteins
Flavonoids are products of secondary metabolism of plants. They are present in herbs and trees and also act as natural chemopreventives and anticancer agents. Ligaria cuneifolia (Ruiz & Pav.) Tiegh., Loranthaceae, is a hemiparasite species that belongs to Argentine flora. Phytochemical studies have disclosed the presence of quercetin, catechin-4β-ol and pro-anthocyanidine as polyphenolic compounds in the active extracts. We previously demonstrated that ethyl acetate extract was capable of reducing cell proliferation and inducing apoptotic death of lymphoid tumor cells. The aim of the current study is to determine whether ...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Copaifera multijuga ethanolic extracts, oil-resin, and its derivatives display larvicidal activity against Anopheles darlingi and Aedes aegypti (Diptera: Culicidae)
Copaifera spp. is a common tree species found in the tropical region of Latin America, popularly known as copaiba or pau-d'alho. Oil-resin from different Copaifera species and its components present several biological activities such as antimicrobial, anti-inflammatory, antioxidant and insecticidal, including larvicidal activity against mosquitoes. Thus, bark and leaf ethanolic extracts, oil-resin, essential oil and alepterolic acid from Copaifera multijuga Hayne, Fabaceae, were tested as larvicides against the main malaria vector in the north of Brazil, Anopheles darlingi and also Aedes aegypti, the dengue vector. A. darl...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Biologically active compounds from cyanobacteria extracts: in vivo and in vitro aspects
An investigation was directed towards the antiacetylcholinesterase activity of the acid aqueous and methanolic extracts of five cyanobacterial taxa, which encompasses an enzymatic inhibition essay and the evaluation of the physiological responses of mice to cyanobacterial extracts along with toxicological observations. The strains Calothrix sp. CCIBt 3320, Tolypothrix sp. CCIBt 3321, Phormidium cf. amoenum CCIBt 3412, Phormidium sp. CCIBt 3265, and Geitlerinema splendidum CCIBt 3223 were from the São Paulo Botanical Institute Cyanobacterial Culture Collection and all of them showed inhibitory effect on acetylcholinesteras...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Comparative effects of mature coconut water (Cocos nucifera) and glibenclamide on some biochemical parameters in alloxan induced diabetic rats
In the present study, comparative effects of mature coconut water (Cocos nucifera L., Arecaceae) and glibenclamide in alloxan induced diabetic rats were evaluated. Diabetes mellitus was induced in Sprague-Dawly rats using alloxan monohydrate (150 mg kg-1 body weight). Treatment with lyophilized form of mature coconut water and glibenclamide in diabetic rats reduced the blood glucose and glycated hemoglobin along with improvement in plasma insulin level. Elevated levels of liver function enzymes markers like alkaline phosphatase, serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase in diabetic...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

The effect of essential oil of Syzygium cumini on the development of granulomatous inflammation in mice
The anti-inflammatory and apoptotic activity of the essential oil of Syzygium cumini (L.) Skeels, Myrtaceae, leaves was investigated in vivo. The anti-inflammatory action and chronic granulomatous inflammation in BALB/c mice, intravenously infected with Mycobacterium bovis, BCG, (Bacillo Calmet Guerim), was judged by measuring and classifying the granulomas formed in the hepatic parenchyma. The degree of apoptosis in the inflammatory cells was also measured. A reduction in the granulomatous area and a change in the pattern of the granulomas were found. Anti-mycobacterial activity of the essential oil against M. bovis was d...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Topical anti-inflammatory activity of yacon leaf extracts
In conclusion, yacon leaf extracts, particularly the sesquiterpene lactone-rich extract, has potential use as topical anti-inflammatory agent. (Source: Revista Brasileira de Farmacognosia)
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Effect of decaffeination of green and roasted coffees on the in vivo antioxidant activity and prevention of liver injury in rats
Decaffeination and roasting affects the composition of the chlorogenic acids in coffee, which have antioxidant potential. The aim of this study was to evaluate the effects of coffee decaffeination on the in vivo antioxidant activity and the prevention of liver damage. The Wistar rats received intraperitoneal doses of carbon tetrachloride and daily doses of Arabica coffee brews (whole and decaffeinated, both green and roasted) by gavage for fifteen days. The activity of liver marker enzymes aspartate aminotransferase, alanine aminotransferase and serum albumin were measured as well as the quantification of the thiobarbituri...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Study on the developmental toxicity of a standardized extract of Orthosiphon stamineus in rats
This study was undertaken to evaluate the developmental toxicity of O. stamineus standardized aqueous extract in female Sprague Dawley rats (n=21) at 0, 250, 500, 1000 and 2000 mg/kg/day, by gavage on gestation days 6-20. Clinical signs of maternal toxicity, body weight gain, and food and water consumption were recorded. Caesarean sections were performed on gestation day 21; resorptions and living and dead fetuses were counted. Fetuses were weighed and examined for external abnormalities. Half of the fetuses from each litter were cleared and stained with Alizarin red S for skeleton evaluation. O. stamineus standardized aqu...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Impact of different extraction methods on the quality of Dipteryx alata extracts
This study aimed to impact of different extraction methods on the quality of Dipteryx alata Vogel, Fabaceae, extracts from fruits. The major compounds found were the lipids 38.9% (w/w) and proteins 26.20% (w/w). The residual moisture was 7.20% (w/w), total fiber 14.50% (w/w), minerals 4.10% (w/w) and carbohydrate 9.10 % (w/w). The species studied has great potential in producing oil, but the content and type of fatty acids obtained is dependent on the method of extraction. The Blingh & Dyer method was more selective for unsaturated fatty acids and Shoxlet method was more selective for saturated fatty acids. The tannin extr...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Studies with Cissampelos sympodialis: the search towards the scientific validation of a traditional Brazilian medicine used for the treatment of asthma
The paper is a review of the literature on the ethnobotanical, chemical and pharmacological aspects of the species Cissampelos sympodialis Eichler, Menispermaceae, in order to assess its potential for the treatment of asthma. The aqueous infusion from the leaves of this Brazilian plant is used in the traditional medicine for the treatment of respiratory conditions, including colds, bronchitis and asthma. A multidisciplinary approach has led to the elucidation of the main chemical biomarkers and of the mechanism of action of the extract and its isolated constituents in animal models of inflammation and asthma. A comprehensi...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Flavonoid electrochemistry: a review on the electroanalytical applications
Flavonoids are polyphenolic compounds widespread in vegetal kingdom. They present a C-15 skeleton, which is divided into three units A, B and C. Unit C is an oxygen containing heterocyclic, whose oxidation state and saturation level define major subclasses. Units A and B are aromatic rings, in which four major types of substituents, i. e. hydroxyl, methoxyl, prenyl and glycosides, lead to over 8000 different flavonoids. The great healthy-protecting value of these phytochemical biomarkers has attracted the attention of scientific community. Their main biological actions include anticancer and anti-inflammatory properties, w...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Argemone mexicana: chemical and pharmacological aspects
The Papaveraceae, informally known as the poppy family, are an ethnopharmacologically important family of 44 genera and approximately 760 species of flowering plants. The present work offers a review addressing the detailed chemistry and pharmacology of Argemone mexicana L. regarded as one of the most significant plant species in traditional system of medicine. The plant is used in different parts of the world for the treatment of several ailments including tumors, warts, skin diseases, inflammations, rheumatism, jaundice, leprosy, microbial infections, and malaria. Interestingly, the plant is the source of a diverse kind ...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Community attitude towards the reproductive rights and sexual life of people living with HIV/AIDS in Olorunda Local Government Area, Osogbo, Nigeria
Asekun-Olarinmoye EO, Asekun-Olarinmoye IO, Adebimpe WO, Olugbenga-Bello AI (Source: Therapeutics and Clinical Risk Management)
Source: Therapeutics and Clinical Risk Management - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Impact of biological sex on the pathophysiology of the heart
Abstract The cardiovascular diseases are the leading causes of death in men and women in industrialised countries. While the impact of biological sex on cardiovascular pathophysiology has long been known, the sex‐specific mechanisms mediating these processes have progressed during the last years. This review aims at analysing the sex‐based differences in cardiac structure and function in adult mammals, and the sex‐based differences in the main molecular mechanisms involved in the response of the heart to pathological situations. It emerged from this review that the sex‐based difference is a variable that should be ...
Source: British Journal of Pharmacology - June 15, 2013 Category: Drugs & Pharmacology Authors: Loubina Fazal, Feriel Azibani, Nicolas Vodovar, Alain Cohen Solal, Claude Delcayre, Jane‐Lise Samuel Tags: Review Article Source Type: research

Systematic review: body composition in adults with inflammatory bowel disease
ConclusionsCurrent data, although heterogeneous, suggest that many patients with IBD are affected by aberrations in fat and lean mass, which may not be detected during routine clinical assessment. The prevalence and impact of altered body composition amongst this population warrant further investigation. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - June 15, 2013 Category: Drugs & Pharmacology Authors: R. V. Bryant, M. J. Trott, F. D. Bartholomeusz, J. M. Andrews Tags: Systematic Review Source Type: research

Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells
Conclusion: We suggest that RP2 inhibitors may be a useful class of agent for targeting dormant leukaemia cells. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 15, 2013 Category: Drugs & Pharmacology Authors: Monica PallisFrancis BurrowsAbigail WhittallNicholas BoddyClaire SeedhouseNigel Russell Source Type: research

β‐Cyclodextrin‐complexed (−)‐linalool produces antinociceptive effect superior to that of (−)‐linalool in experimental pain protocols
In this study, the antinociceptive effect of (−)‐linalool and (−)‐linalool/β‐CD was examined using the acetic acid writhing reflex, formalin and hotplate tests in rodents. (−)‐Linalool and (−)‐linalool/β‐CD demonstrated strong antinociceptive activity in all the chemical‐ and heat‐induced mice models (p < 0.01 or p < 0.001). These findings imply the involvement of both peripheral and central antinociceptive mechanisms. In peritonitis induced by carrageenan, isolated monoterpene or β‐CD complex also reduced total leucocyte migration and TNF‐α levels in peritoneal fluid. The inclusio...
Source: Basic and Clinical Pharmacology and Toxicology - June 15, 2013 Category: Drugs & Pharmacology Authors: Lucindo J. Quintans‐Júnior, Rosana S. S. Barreto, Paula P. Menezes, Jackson R. G. S. Almeida, Ana Flávia S. C. Viana, Rita C. M. Oliveira, Aldeídia P. Oliveira, Daniel P. Gelain, Waldecy Lucca Júnior, Adriano A. S. Araújo Tags: Original Article Source Type: research

Activity of Dexrazoxane and Amifostine Against Late Cardiotoxicity Induced by the Combination of Doxorubicin and Cyclophosphamide In Vivo
Abstract Cardiotoxicity is one of the main limiting side effects of doxorubicin and cyclophosphamide (DC) treatment, and this study was organized to identify cardioprotective activity of amifostine and dexrazoxane against DC combination. BalbC/NIH mice underwent DC treatment (DC group), were pre‐treated with amifostine (ADC group) or dexrazoxane (IDC group) and were killed at 1.5 and 3 months after treatments when the grade of myocardial damage was analysed by light microscopy using the Billingham scoring method. DC treatment induced severe myocardial damage with one lethal event before evaluation at 3 months. Main cha...
Source: Basic and Clinical Pharmacology and Toxicology - June 15, 2013 Category: Drugs & Pharmacology Authors: Snezana K. Bjelogrlic, Silvana T. Lukic, Slavisa M. Djuricic Tags: Original Article Source Type: research

Fructose and Lactose Intolerance and Malabsorption TestingFructose and Lactose Intolerance and Malabsorption Testing
What do researchers know about the connection between fructose and lactose intolerance and symptoms related to functional gastrointestinal disorders? Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 14, 2013 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Xgeva Approved for Rare, Non-Malignant Tumor
Title: Xgeva Approved for Rare, Non-Malignant TumorCategory: Health NewsCreated: 6/13/2013 2:35:00 PMLast Editorial Review: 6/14/2013 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - June 14, 2013 Category: Drugs & Pharmacology Source Type: news

Bloxiverz (Neostigmine Methylsulfate Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 14, 2013 Category: Drugs & Pharmacology Source Type: news

The Future of Drug Development? Seeking Evidence of Activity of Novel Drugs in Small Groups of Patients [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - June 14, 2013 Category: Cancer & Oncology Authors: Sleijfer, Ballman, Verweij Tags: Clinical Trials, Phase I and Clinical Pharmacology, Chemotherapy, Translational Oncology, Phase I and Clinical Pharmacology EDITORIALS Source Type: research

Computational analysis of protein-protein interfaces involving an alpha helix: insights for terphenyl--like molecules binding
Conclusions: The presence of hydrophobic cavities at the protein surface with a more complex shape than the entire protein surface seems to be an important property related to the ability of proteins to bind alpha-helical peptides and low molecular weight mimetics. Characterization of similarities and specificities of PPI binding sites can be helpful for further development of small molecules targeting alpha-helix binding proteins. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 14, 2013 Category: Drugs & Pharmacology Authors: Adriana IsvoranDana CraciunVirginie MartinyOlivier SperandioMaria Miteva Source Type: research

Chronic treatment with taurine ameliorates diabetes‐induced dysfunction of nitric oxide‐mediated neurogenic and endothelium‐dependent corpus cavernosum relaxation in rats
This study was aimed to examine the effect of chronic taurine treatment on corpus cavernosum dysfunction in diabetic rats and to investigate possible underlying mechanisms.Thirty male rats were randomized to three groups of ten each, including control, diabetic, and taurine‐treated diabetic. Diabetes was induced in rats by streptozotosin (STZ, single intraperitoneal dose of 50 mg/kg body weight). Taurine was administered orally for 12 weeks (1% w/v in drinking water) from the day on which STZ was injected. At the end ofthe 12th week, strips of corpus cavernosum were suspended in an organ bath system for functional studie...
Source: Fundamental and Clinical Pharmacology - June 14, 2013 Category: Drugs & Pharmacology Authors: Selvinaz Dalaklioglu, Nilay Kuscu, Ciler Celik‐Ozenci, Zeliha Bayram, Cahit Nacitarhan, Sadi Satilmis Ozdem Tags: Original Article Source Type: research

Baldness Drug Propecia May Put Some Men Off Alcohol
Men with sexual side effects appear to drink less, even after they stop taking the drug Source: HealthDay Related MedlinePlus Pages: Alcohol, Drug Reactions, Hair Loss (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - June 13, 2013 Category: Consumer Health News Source Type: news

SIRT1-Mediated FoxO1 Deacetylation Is Essential for Multidrug Resistance-Associated Protein 2 Expression in Tamoxifen-Resistant Breast Cancer Cells
Molecular PharmaceuticsDOI: 10.1021/mp400287p (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - June 13, 2013 Category: Drugs & Pharmacology Authors: Hoo-Kyun Choi, Kyoung Bin Cho, Nguyen Thi Thuy Phuong, Chang Yeob Han, Hyo-Kyung Han, Tran Thi Hien, Hong Seok Choi and Keon Wook Kang Source Type: research

Synergistic Interaction of Paclitaxel and Curcumin with Cyclodextrin Polymer Complexation in Human Cancer Cells
Molecular PharmaceuticsDOI: 10.1021/mp400101k (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - June 13, 2013 Category: Drugs & Pharmacology Authors: Ali O. Boztas, Ozgur Karakuzu, Gabriela Galante, Zafer Ugur, Fatih Kocabas, Cengiz Z. Altuntas and A. Ozgur Yazaydin Source Type: research

Aqueous Solubility Prediction: Do Crystal Lattice Interactions Help?
Molecular PharmaceuticsDOI: 10.1021/mp4001958 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - June 13, 2013 Category: Drugs & Pharmacology Authors: Maryam Salahinejad, Tu C. Le and David A. Winkler Source Type: research

Drug shortages in hospital pharmacies
There is anecdotal evidence that shortages of drugs are occurring and increasing in European countries. These drug shortages pose challenges to patients, pharmacists, clinicians, the pharmaceutical industry and policy makers (Source: Pharmacy Europe)
Source: Pharmacy Europe - June 13, 2013 Category: Drugs & Pharmacology Source Type: news

PegIntron (Peginterferon alfa-2b and Ribavirin Combo Pack) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 13, 2013 Category: Drugs & Pharmacology Source Type: news

Adverse drug reactions reported by consumers for nervous system medications in Europe 2007 to 2011
Conclusions: The majority of ADRs from nervous system mediations reported by consumers that were identified from the EudraVigilance database were serious. The value of consumer reports in pharmacovigilance still remains unclarified. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - June 13, 2013 Category: Drugs & Pharmacology Authors: Lise AagaardEbba Hansen Source Type: research