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This page shows you the most recent publications within this specialty of the MedWorm directory.

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RPS Conference 2010: Supporting patient and professional decision makingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This conference will have a practice and professional focus and will explore patient and professional decision making. Find out more about the programme and how to book your place. (Source: Royal Pharmaceutical Society of Great Britain)
Source: Royal Pharmaceutical Society of Great Britain - March 19, 2010 Category: Drugs & Pharmacology Source Type: organizations

Teva set for £3.2bn Ratiopharm dealEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pharmaceutical company Teva has acquired generic drug maker Ratiopharm for £3.2 billion, beating rivals Pfizer and Actavis to the deal. (Source: Pharmacy Europe)
Source: Pharmacy Europe - March 19, 2010 Category: Drugs & Pharmacology Source Type: news

No ban for "pay-for-delay" dealsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lobbyists for the generic drug industry have revealed that proposals, which would have banned multibillion-dollar deals between pharmaceutical giants and generic rivals, were removed from US healthcare legislation at the last minute. (Source: Pharmacy Europe)
Source: Pharmacy Europe - March 19, 2010 Category: Drugs & Pharmacology Source Type: news

Jury: Drug did not lead to diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A US jury found a psychiatric drug did not trigger diabetes in a veteran of the Vietnam war, British pharmaceutical company AstraZeneca has said. (Source: Pharmacy Europe)
Source: Pharmacy Europe - March 19, 2010 Category: Drugs & Pharmacology Source Type: news

Apparently No Sedative Benzoflavone Moiety in Passiflorae HerbaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1241015AbstractDue to the fact that an Indian group had reported a benzoflavone moiety (BZF) as an active principle in the herb of L. (Passifloraceae), this study was performed to isolate the compound for analytical purposes. In Passiflorae herba from three different origins (cultivations in India, Italy and France) a compound with the published TLC characteristics was detected in trace amounts only in the Italian material. No traces of the substance were found in the drugs from India and France. In a commercial extract two compounds with the respective TLC characteristics were detected. One w...
Source: Planta Medica - March 19, 2010 Category: Drugs & Pharmacology Tags: Rapid Communications Source Type: journals

Enhancement of Artemisinin Content through Four Cycles of Recurrent Selection with Relation to Heritability, Correlation and Molecular Marker in Artemisia annua L.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240940AbstractDue to the high demand and low yield of the anti-malarial drug artemisinin in natural populations of (Quinghao), an attempt has been made to enhance the artemisinin content through 4 cycles of recurrent selection (C-C) using selected genotypic and phenotypic traits. Based on their phenotypic and genotypic characteristics, the top 5 % plants of each cycle were selected, and their seedlings were planted in poly-cross block to produce seeds for the subsequent generation. A significant increase in the artemisinin content (0.15 % in C to 1.16 % in C, i.e., about 40&...
Source: Planta Medica - March 19, 2010 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Anti-adipogenic Activities of Alnus incana and Populus balsamifera Bark Extracts, Part I: Sites and Mechanisms of ActionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240941AbstractObesity is an epidemic in most developed countries and novel therapeutic approaches are needed. In the course of a screening project of medicinal plants used by the Eastern James Bay Cree of Canada and having potential for the treatment of diabetes, we have identified several products that inhibit adipogenesis, suggesting potential antiobesity activities. The inhibitory activity of two of these, the extract of the inner bark of the deciduous trees ssp. (Speckled Alder) and L. (Balsam Poplar), was analyzed using the 3T3-L1 cell model of adipogenesis. Intracellular triglyceride ac...
Source: Planta Medica - March 19, 2010 Category: Drugs & Pharmacology Tags: Original Papers Source Type: journals

Anti-adipogenic Activities of Alnus incana and Populus balsamifera Bark Extracts, Part II: Bioassay-guided Identification of Actives Salicortin and OregoninEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240991AbstractAmong modern day metabolic diseases, obesity has reached epidemic proportions worldwide and novel therapeutic support strategies are urgently needed. Adipocytes are interesting targets in this context. Using ethnobotanical and bioassay screening techniques, we have identified two Boreal Forest plants used by the James Bay Cree that potently inhibit adipogenesis, namely ssp. (Speckled Alder) and (Balsam Poplar). The mode of action of this inhibitory activity was reported in a companion paper. The current study report the results of a classical bioassay-guided fractionation approa...
Source: Planta Medica - March 19, 2010 Category: Drugs & Pharmacology Tags: Original Paper Source Type: journals

Optimizing management of treatment-naïve and treatment-experienced HIV+ patients: the role of maravirocEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eva Poveda, Vincent Soriano (Source: Therapeutics and Clinical Risk Management)
Source: Therapeutics and Clinical Risk Management - March 19, 2010 Category: Drugs & Pharmacology Source Type: journals

Taking the Patient's Side: The Ethics of PharmacogeneticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The encouraging vision that is now being established is that we may move from trial and error therapies to evidence-based personalized medicine in clinical practice. Personalized Medicine (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - March 19, 2010 Category: Drugs & Pharmacology Tags: Med Students Source Type: info

FDA Clears Non-Abusable Insomnia TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
WASHINGTON (MedPage Today) -- The FDA approved doxepin (Silenor) for use in patients with long or short term insomnia and sleep maintenance difficulty. (Source: MedPage Today Product Alert)
Source: MedPage Today Product Alert - March 19, 2010 Category: Drugs & Pharmacology Source Type: news

SSRIs May Boost Risk for CataractsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SSRIs have been linked to an increased risk for cataracts, but researchers say the effect size is modest and needs to be investigated further. Medscape Medical News (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - March 19, 2010 Category: Drugs & Pharmacology Tags: Psychiatry Source Type: info

Neuro-Oncologists Extend Survival in Nervous System CancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical and basic science advances have improved outcomes for patients with nervous system cancers, a new series of articles show. Medscape Medical News (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - March 19, 2010 Category: Drugs & Pharmacology Tags: Neurology & Neurosurgery Source Type: info

FDA Drafts New Rules For Testing, Approving Drug Cocktails; Public-Private Partnership For TB Treatment Development LaunchedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The FDA is drafting new guidelines for testing and approving multidrug cocktails for life-threatening diseases, the Wall Street Journal reports. "Many diseases, such as AIDS, tuberculosis and cancer, require multidrug combinations... (Source: MRSA / Drug Resistance News From Medical News Today)
Source: MRSA / Drug Resistance News From Medical News Today - March 19, 2010 Category: Drugs & Pharmacology Tags: Tuberculosis Source Type: news

Briefing: Should miaow-miaow be banned?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A slew of recent deaths linked to mephedrone have led to vociferous calls for a ban in the UK. What is – and isn't – known about this "legal high"? (Source: New Scientist - Drugs and Alcohol)
Source: New Scientist - Drugs and Alcohol - March 19, 2010 Category: Drugs & Pharmacology Source Type: journals

France's National Program To Reduce HAIs Reports Important Successes; Uses Mandatory ReportingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers evaluating France's national infection control program for healthcare facilities found significant decreases in the rates of healthcare-associated infections (HAIs) since 2004. The drop in HAIs, including MRSA and surgical site infections, could be attributed to important changes in the national infection control system... (Source: MRSA / Drug Resistance News From Medical News Today)
Source: MRSA / Drug Resistance News From Medical News Today - March 19, 2010 Category: Drugs & Pharmacology Tags: MRSA / Drug Resistance Source Type: news

Antitrypanosomal Activity of a Diterpene and Lignans Isolated from Aristolochia cymbiferaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1240952AbstractBioguided fractionation of extract from the leaves of led to the isolation of the furofuran lignans fargesin, epieudesmin, and sesamin; the dibenzylbutyrolactone lignans hinokinin and kusunokinin; and an -labdane diterpene named copalic acid. Our data demonstrated that copalic acid and kusunokinin were the most active compounds against trypomastigotes of . Additionally, copalic acid demonstrated the highest parasite selectivity as a result of low toxicity to mammalian cells, despite a considerable hemolytic activity at higher concentrations. Among the isolated compounds, kusunok...
Source: Planta Medica - March 19, 2010 Category: Drugs & Pharmacology Tags: Letters Source Type: journals

Neuroleptic malignant syndrome and its controversiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neuroleptic malignant syndrome (NMS) is a rare and life threatening condition usually defined as a complication of treatment with antipsychotics characterized by severe rigidity, tremor, fever, altered mental status, autonomic dysfunction, and elevated serum creatine phosphokinase and white blood cell count. The literature on this topic is rather extensive, but many aspects related to the syndrome are thought to be controversial. The aim of this paper, written with the clinician in mind, is to summarize some of the most prominent controversies that may have importance in usual clinical practice.The literature was searched ...
Source: Pharmacoepidemiology and Drug Safety - March 19, 2010 Category: Drugs & Pharmacology Authors: Branimir Margeti[cacute], Branka Aukst Margeti[cacute] Source Type: journals

Laboratory monitoring and adverse patient outcomes with antihypertensive therapy in primary careEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The monitoring of serum electrolyte and creatinine concentrations in patients treated with antihypertensive therapy is recommended. We wished to examine the relationship between laboratory monitoring and adverse patient outcomes.We carried out a retrospective cohort study using the General Practice Research Database (GPRD). Patients aged 18 years or older with newly diagnosed hypertension and prescribed a single antihypertensive agent were included. Monitoring was defined as any laboratory test for serum electrolyte and creatinine (or urea) concentrations within 6 months of starting treatment.We identified 74 096 patients ...
Source: Pharmacoepidemiology and Drug Safety - March 19, 2010 Category: Drugs & Pharmacology Authors: Sarah E. McDowell, Jamie J. Coleman, Stephen J. W. Evans, Paramjit S. Gill, R. E. Ferner Source Type: journals

Society responds to consultation on pharmacy needs assesmentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Royal Pharmaceutical Society responded to the Department of Health's consultation on the draft regulations under the Health Act 2009: Pharmaceutical Needs Assessments (PNAs). (Source: Royal Pharmaceutical Society of Great Britain)
Source: Royal Pharmaceutical Society of Great Britain - March 18, 2010 Category: Drugs & Pharmacology Source Type: organizations

PCR/LDR/Universal Array Platforms for the Diagnosis of Infectious DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Infectious diseases account for between 14 and 17 million deaths worldwide each year. Accurate and rapid diagnosis of bacterial, fungal, viral, and parasitic infections is therefore essential to reduce the morbidity and mortality associated with these diseases. Classical microbiological and serological methods have long served as the gold standard for diagnosis but are increasingly being replaced by molecular diagnostic methods that demonstrate increased sensitivity and specificity and provide an identification of the etiologic agent in a shorter period of time. PCR/LDR coupled with universal array detection provides a hig...
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

The Use of Microarray Technology for CytogeneticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of microarray technology is revolutionizing the field of clinical cytogenetics. This new technology has transformed the cytogenetics laboratory by adapting techniques that have heretofore been the province of molecular geneticists. Intimate knowledge and comfortable familiarity with these techniques are now a must for the modern cytogeneticist, rather than a stimulating but discretionary intellectual exercise or an elective luxury. The cytogenetic laboratory of the future will likely have more scanners than microscopes, more software packages than darkrooms, and more technologists, supervisors, and directors with m...
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

DMET™ Microarray Technology for Pharmacogenomics-Based Personalized MedicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human genome sequence variation in the form of single nucleotide polymorphisms (SNPs) as well as more complex structural variation such as insertions, duplications, and deletions underlies each individual’s response to drugs and thus the likelihood of experiencing an adverse drug reaction. The ongoing challenge of the field of pharmacogenetics is to further understand the relationship between genetic variation and differential drug responses, with the overarching goal being that this will lead to improvements in both the safety and efficacy of drugs. The Affymetrix® DMET™ Plus Premier Pack (DMET stands for ...
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

TaqMan® Array Cards in Pharmaceutical ResearchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
TaqMan® Array Cards are high-throughput, accurate, sensitive, and simple-to-use tools for quantitative analysis of mRNA or miRNA transcripts using a real-time PCR protocol. They utilize a microfluidic card with 384 reaction chambers and eight sample loading ports. For studies of coding transcripts, the reaction chambers are preloaded with user selected or predefined panels of Applied Biosystems TaqMan Gene Expression Assays. These assays enable real-time monitoring of a PCR reaction via hydrolysis of an oligonucleotide probe which has been dual labeled with fluorescent dye and quencher. Applications of TaqMan Array Car...
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

Profiling microRNA Expression with the Illumina BeadChip PlatformEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The complex mechanisms involved in the regulation of both gene and protein expressions are still being understood. When microarray technology was first introduced during the early to mid 1990s, they heralded a tremendous opportunity to study transcription on a global scale. Despite this promise, however, one thing that has become clear is that the expression of protein coding genes is not the only aspect of the transcriptome that researchers need pay attention to. Small noncoding RNAs, such as microRNAs, are now known to play a pivotal role in the control of both gene and protein expressions. Each microRNA may act upon a p...
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

Determination of Alternate Splicing Events Using the Affymetrix Exon 1.0 ST ArraysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we describe a method using this technology to study the generation of alternative mRNA transcripts in breast cancer cells that differ in the levels of a particular integrin, α3β1. (Source: Springer protocols feed by Pharmacology/Toxicology)
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

Microarray Analysis of Embryonic Stem Cells and Differentiated Embryoid BodiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
By altering the cellular microenvironment and culture media composition, embryonic stem cells (ESCs) can be induced to differentiate in vitro into somatic cell types from the three primitive germ layers. ESC differentiation is regulated by an intricate series of signaling events that result in their transcriptional reprogramming, asymmetric cell division, and differentiation. Using various pharmacological agents and/or genetic manipulations, one can drive and enrich ESC differentiation to specific cell lineages. Identifying the transcriptional fingerprint during ESC differentiation could yield novel targets for genetic or ...
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

Isolation of Total RNA from Transgenic Mouse Melanoma Subsets Using Fluorescence-Activated Cell SortingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The majority of tumors, including melanoma, are phenotypically heterogeneous in that they contain various cell populations with differential expression of cell surface antigens such as CD133/Prominin-1. We have used fluorescence-activated cell sorting (FACS) technology to purify CD133+ and CD133− cellular subsets from mouse melanoma models for high-quality total RNA practical for downstream applications such as expression profiling. Implementation of this strategy can lead to higher resolution of transcripts that are potentially important for the survival and functionality of one cancer cell population relative to an...
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

Multicenter Clinical Sample Collection for Microarray AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this chapter, we describe numerous methods to extract RNA, DNA, and protein from tissue, represented by kidney transplant biopsies, and from peripheral blood cells collected at various clinical sites. Gene expression profiling and SNP-based genome-wide association studies are done using various microarray platforms. In addition, protocols that enable simultaneous protein purification from these clinical samples, enable additional strategies for understanding of the molecular processes involved in organ transplantation, immunosuppressive drug regimens, and the elements determining allograft success and failure. Successfu...
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

Production and Application of Glycan MicroarraysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glycans are vital elements of living organisms and are involved in recognition, communication, cell growth and development, motility, and other significant processes. The interactions of glycans with the proteins that bind them provide valuable information about protein interaction and specificity. By printing glycans on microarrays, investigators are able to effectively determine the binding specificity of certain proteins with an extremely efficient and precise result. Such chips are performed by standard robotic microarray printing. Incubating the slides with various GBP-containing substances not only reveals clear rece...
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

Small Molecule Selectivity and Specificity Profiling Using Functional Protein MicroarraysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Small molecules interact with proteins to perturb their functions, a property that has been exploited both for research applications and to produce therapeutic agents for disease treatment. Commonly utilized approaches for identifying the target proteins for a small molecule have limitations in terms of throughput and resource consumption and lack a mechanism to broadly assess the selectivity profile of the small molecule. Here we describe how protein microarray technology can be applied to the study of small molecule-protein interactions using tritiated small molecules. Protein arrays comprising thousands of full-length f...
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

Use of Tissue Microarray to Facilitate Oncology ResearchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HPV-positive oropharyngeal squamous cell carcinomas (OSCC) represent a distinct disease entity from traditional OSCC. We hypothesized that for HPV DNA-positive cases, p16 expression status differentiates the biologically relevant ones. (Source: Springer protocols feed by Pharmacology/Toxicology)
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

Metabolic Enzyme Microarray Coupled with Miniaturized Cell-Culture Array Technology for High-Throughput Toxicity ScreeningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Due to poor drug candidate safety profiles that are often identified late in the drug development process, the clinical progression of new chemical entities to pharmaceuticals remains hindered, thus resulting in the high cost of drug discovery. To accelerate the identification of safer drug candidates and improve the clinical progression of drug candidates to pharmaceuticals, it is important to develop high-throughput tools that can provide early-stage predictive toxicology data. In particular, in vitro cell-based systems that can accurately mimic the human in vivo response and predict the impact of drug candidates on huma...
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

High-Throughput Screening of Metalloproteases Using Small Molecule MicroarraysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The promise of rapid and cost-effective drug screening assays on solid support is one that may now be realized with the advent of small molecule microarrays. Many of the initial hurdles in library design and microarray fabrication have been overcome over the last decade, allowing this platform to become more accessible to researchers across both the academic and industrial spheres. Beyond pharmaceutical screening, microarrays reveal quantitative ligand-binding signatures that in the form of protein fingerprints provide a means to discriminate between closely related proteins. The value of protein fingerprinting in drug dis...
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

HELP (HpaII Tiny Fragment Enrichment by Ligation-Mediated PCR) Assay for DNA Methylation Profiling of Primary Normal and Malignant B LymphocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The role of cytosine methylation in the regulation of gene expression during normal development and malignant transformation is currently under intense investigation. An ever increasing body of evidence demonstrates that carcinogenesis is associated with aberrant DNA methylation of the promoters of tumor suppressor genes (Chin Med J (Engl) 111:1028-1030, 1998; Leukemia 17:2533-2535, 2003), hypomethylation of oncogenes (Toxicol Appl Pharmacol 206:288-298, 2005; Toxicology 50:231-245, 1988), and concurrent loss of methylation in the intergenic areas and gene bodies, which may lead to genomic instability and chromosomal fragi...
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

ChIPing Away at Global Transcriptional RegulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The regulation of gene expression impacts all aspects of cell biology and biochemistry. As we gain a greater understanding of the mechanisms involved in this process, we also begin to unveil its complexities. The delicate balancing act played out by the multitude of DNA interacting proteins can easily become unhinged. The implications of this may potentially lead to cell death or a diseased state. Recent microarray technologies are now allowing scientists to begin the journey into characterizing the relationship between gene expression and DNA modifying proteins. For example, genome-wide studies of protein-DNA interactions...
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

RIP-CHIP in Drug DevelopmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Microarrays are extensively used to evaluate the effects of compounds on gene expression in the cells. Most of the studies so far have analyzed the transcriptome of the cell. The basic assumption of this approach is that the changes in gene expression occur at the level of transcription of a gene. However, changes often occur at the posttranscriptional level and are not reflected in the analysis of whole transcriptome. We have pioneered the development of “ribonomic profiling” as a high-throughput method to study posttranscriptional regulation of gene expression in the cell. This method is also often referred t...
Source: Springer protocols feed by Pharmacology/Toxicology - March 18, 2010 Category: Drugs & Pharmacology Source Type: info

EU approves meningococcal vaccineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Swiss drug giant Novartis has won approval from Europe's health regulator for its new meningococcal vaccine following support from US authorities last month. (Source: Pharmacy Europe)
Source: Pharmacy Europe - March 18, 2010 Category: Drugs & Pharmacology Source Type: news

Roche to expand drug portfolioEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cancer drug specialist Roche Holding AG has announced plans to expand its product portfolio and branch out into the therapeutic areas of metabolism, inflammation and diseases, Reuters reports. (Source: Pharmacy Europe)
Source: Pharmacy Europe - March 18, 2010 Category: Drugs & Pharmacology Source Type: news

Baby "was given wrong prescription"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An inquest into the death of a four-month-old baby has heard how the wrong prescription was issued by a GP, resulting in a medication overdose. (Source: Pharmacy Europe)
Source: Pharmacy Europe - March 18, 2010 Category: Drugs & Pharmacology Source Type: news

Review article: the modern management of autoimmune hepatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Despite ongoing limitations in the understanding of pathogenesis and difficulties in evaluating novel therapies, the management of AIH continues to evolve slowly. Multi-centre collaboration is necessary to obtain sufficient patient numbers to undertake good quality therapeutic studies. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 18, 2010 Category: Drugs & Pharmacology Authors: A. D. YEOMAN, M. S. LONGHI, M. A. HENEGHAN Tags: Review article Source Type: journals

FDA Okays First Totally Implanted Hearing AidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
WASHINGTON (MedPage Today) -- The FDA has approved the first implanted hearing aid device for moderate to severe sensorineural hearing loss in adults. (Source: MedPage Today Product Alert)
Source: MedPage Today Product Alert - March 18, 2010 Category: Drugs & Pharmacology Source Type: news

Effects of Experimental Setup on the Apparent Concentration Dependency of Active Efflux Transport in in Vitro Cell Permeation ExperimentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Molecular Pharmaceutics, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - March 18, 2010 Category: Drugs & Pharmacology Tags: article Source Type: journals

Antiseptic Cloths Associated With Reduced Rate Of Treatment-Resistant Bacteria In The Trauma CenterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bathing trauma patients daily using cloths containing the antiseptic chlorhexidine may be associated with a decreased rate of colonization and infection by methicillin-resistant Staphylococcus aureus (MRSA) and other difficult-to-treat bacteria, according to a report in the March issue of Archives of Surgery, one of the JAMA/Archives journals... (Source: MRSA / Drug Resistance News From Medical News Today)
Source: MRSA / Drug Resistance News From Medical News Today - March 18, 2010 Category: Drugs & Pharmacology Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

New Policy Statement Describes The Development Of Antibiotics To Protect Our Children And Future Generations As A "Moral Obligation"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As the deaths and suffering caused by antibiotic-resistant bacterial infections continue to rise around the world, the Infectious Diseases Society of America (IDSA) is urging a global commitment to develop 10 new antibiotics by 2020, known as the 10 x '20 initiative, to address this public health crisis and safeguard patients' health. The plea for U.S... (Source: MRSA / Drug Resistance News From Medical News Today)
Source: MRSA / Drug Resistance News From Medical News Today - March 18, 2010 Category: Drugs & Pharmacology Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

SWINEAID (Arginine Aminobenzoate) Cream [EpiCare Limited]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Mar 18, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - March 18, 2010 Category: Drugs & Pharmacology Source Type: organizations

DUETACT (Pioglitazone Hydrochloride And Glimepiride) Tablet [Takeda Pharmaceuticals America, Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Mar 18, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - March 18, 2010 Category: Drugs & Pharmacology Source Type: organizations

FLEXERIL (Cyclobenzaprine Hydrochloride) Tablet, Film Coated [Ortho-McNeil-Janssen Pharmaceuticals, Inc]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Mar 18, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - March 18, 2010 Category: Drugs & Pharmacology Source Type: organizations

PENTASA (Mesalamine) Capsule [Shire US Manufacturing Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Mar 18, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - March 18, 2010 Category: Drugs & Pharmacology Source Type: organizations

PEGASYS (Peginterferon Alfa-2a) Injection, Solution [Hoffmann-La Roche Inc]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Mar 18, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - March 18, 2010 Category: Drugs & Pharmacology Source Type: organizations