Drugs & Pharmacology This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 30.

Longer-acting human growth hormone (hGH-CTP) receives orphan drug designation in Europe
Source: BioSpace Area: News The European Medicines has granted orphan drug designation to hGH-CTP, a longer-acting version of human growth hormone in development for the treatment of growth hormone deficiency. In Phase II studies in growth hormone-deficient adults, hGH-CTP was reported to be safe and well tolerated, and it demonstrated the potential to be administered once-weekly, replacing seven daily injections of currently marketed human growth hormone. The company PROLOR has initiated a phase II trial in children with growth hormone deficiency and plans a phase III trial in growth hormone-deficient adults, which is s...
Source: NeLM - News - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

FDA grants 'Breakthrough Therapy Designation' to ibrutinib for treatment of relapsed or refractory mantle cell lymphoma and Waldenstrom's macroglobulinemia
Source: BioSpace , PharmaTimes Area: News The FDA has granted 'Breakthrough Therapy Designation' to ibrutinib (as monotherapy) for the treatment of patients with relapsed or refractory mantle cell lymphoma (MCL) and for the treatment of patients with Waldenstrom's macroglobulinemia (WM). Ibrutinib is an investigational oral agent designed to specifically target and selectively inhibit an enzyme called Bruton's tyrosine kinase (BTK), a key mediator of at least three critical B-cell pro-survival mechanisms occurring in parallel regulating apoptosis, adhesion, and cell migration and homing. The Breakthr...
Source: NeLM - News - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

Kidney Disease CCG Profiles
Source: NHS Kidney Care Area: News NHS Kidney Care has produced a kidney disease profile for each of the 211 clinical commissioning groups (CCGs). The profiles are intended to help CCGs and other stakeholders, assess local kidney care need and current service levels in order to inform planning and facilitate improvements where necessary in the quality and productivity of services for those with kidney disease. The profiles contain information for each CCG on: . Observed and expected number of people with chronic kidney disease . Clinical management and achievement of chronic kidney diseas...
Source: NeLM - News - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

CADTH rapid review: Probiotics for antibiotic-associated diarrhoea, clostridium difficile infection and irritable bowel syndrome
Source: Canadian Agency for Drugs and Technologies in Health (CADTH) Area: News This Canadian review examines the efficacy and safety of probiotics in antibiotic-associated diarrhoea (AAD), clostridium difficile infection (CDI) and irritable bowel syndrome (IBS). A total of one health technology assessment, five systematic reviews/meta-analyses, and 25 RCTs were included in this review. Some of the findings reported were as follows: . There is a lack of assessment and systematic reporting of adverse events in probiotic trials. . Evidence from two meta-analyses indicated probiotic...
Source: NeLM - News - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

Australia launches national scheme to vaccinate boys against HPV
Source: BMJ Area: News According to a BMJ news report, Australia has started to vaccinate boys against human papillomavirus (HPV), making it the first country in the world to publicly fund HPV vaccination of this group, in a bid to protect against genital warts and anal, penile, and throat cancers. Starting in February, they will receive three doses of the quadrivalent vaccine Gardasil at ages 12-13, as part of a national, federally funded school based programme. A catch-up scheme will also run for 14-15 year old boys until the end of the school year in 2014. It will cost the federal government £13.8m over four years, in...
Source: NeLM - News - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

Statement from Chief Medical Officer on Bute in horsemeat
Source: Department of Health (DH) Area: News The Chief Medical Officer has issued the following statement on horsemeat containing phenylbutazone (Bute), stressing that it presents a very low risk to human health: "At the levels of bute that have been found, a person would have to eat 500 to 600 burgers a day that are 100% horse meat to get close to consuming a human's daily dose. And it passes through the system fairly quickly, so it is unlikely to build up in our bodies. In patients who have been taking phenylbutazone as a medicine there can be serious side effects but these are rare. It is extremely unlikely ...
Source: NeLM - News - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

BNF and BNF for Children update for health professionals February 2013
Source: BNF Area: News The following information has been updated in the BNF and/or BNF for Children: BNF update . Paracetamol poisoning [updated advice on management], Emergency Treatment of Poisoning . Ivabradine for the treatment of chronic heart failure [NICE guidance], section 2.6.3 . Mannitol dry powder for inhalation for treating cystic fibrosis [NICE guidance], section 3.7 . Treatment of hereditary angioedema updated, section 3.4.3 . Denosumab for the prevention of skeletal-related events in adults with bone metastases from solid tumours [NICE guidance], section 6.6.2...
Source: NeLM - News - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

NHS Evidence expert commentary: Prevention of ventilator-associated pneumonia with oral antiseptics
Source: NHS Evidence Area: News The February edition of 'Eyes on Evidence', the free monthly e-bulletin from NHS Evidence covering major new published evidence as it emerges with an explanation about what it means for current practice, includes an expert commentary on new data from a systematic review and random effects meta-analysis assessing the effect of oral care with chlorhexidine or povidone-iodine on the prevalence of ventilator-associated pneumonia (VAP) compared with oral care without these antiseptics in adults. Overall, antiseptic use resulted in a significant risk reduction of VAP (relative risk [RR...
Source: NeLM - News - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

NHS Evidence expert commentary: Benzodiazepines and the risk of dementia
Source: NHS Evidence Area: News The February edition of 'Eyes on Evidence', the free monthly e-bulletin from NHS Evidence covering major new published evidence as it emerges with an explanation about what it means for current practice, includes an expert commentary on new data from a prospective population based cohort study assessing whether there was an association between starting benzodiazepines, and similar drugs, and risk of subsequent dementia in 1063 people aged 65 years and over (mean age 78.2 years). The total study duration was 20 years, including a 5 year observation period and a 15-year assessment period. Pat...
Source: NeLM - News - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

RCT: Neurostimulation for Parkinson's disease with early motor complications
Source: N Engl J Med Area: News Subthalamic stimulation reduces motor disability and improves quality of life in patients with with advanced Parkinson's disease who have severe levodopa-induced motor complications. The EARLYSTIM Study Group hypothesised that neurostimulation would be beneficial at an earlier stage of Parkinson's disease. The group conducted a 2-year trial in 251 patients with Parkinson's disease and early motor complications (mean age, 52 years; mean duration of disease, 7.5 years) who were randomised to undergo neurostimulation plus medical therapy or medical therapy alone. The primary end poi...
Source: NeLM - News - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

Phase II trial: Ganitumab with either exemestane or fulvestrant for postmenopausal women with advanced, hormone-receptor-positive breast cancer
Source: Lancet Oncology Area: News Inhibition of oestrogen receptor is a mainstay of treatment for oestrogen-receptor-positive breast cancer but intrinsic and acquired resistance undermine the long-term effectiveness of endocrine treatments and lead to relapses in early stage disease. This has led to a drive to develop targeted therapies and integrate them into existing treatment strategies. Oestrogen receptor signalling is linked to many other cell signalling pathways, including those related to growth hormones and insulin-like growth factor (IGF). IGF-1 and IGF-2 bind to the IGF-1 receptor (IGF-1R), increasing cell prol...
Source: NeLM - News - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

DTB questions current arrangements for supply of gluten free food
Source: DTB Area: News Gluten-free staples such as bread and flour were first made available on prescription in the late 1960s. Figures from 2011 show that the NHS in England spent £27 million on gluten-free food. With growing pressure on primary care budgets, and increasing awareness and availability of gluten-free food in shops and supermarkets, this article in the Drug and Therapeutics Bulletin (DTB) questions whether the current arrangements for supplying such products is appropriate. It notes the different arrangements across PCTs for supply of gluten-free foods, but which still leaves the supply process ...
Source: NeLM - News - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: qualitative and quantitative assessment
Source: Lancet Infectious Diseases Area: News The novel multicomponent protein-based vaccine against meningococcal capsular group B (MenB), 4CMenB represents the culmination of decades of research, and its licensing in the EU is considered a major public health milestone. In The Lancet Infectious Diseases, researchers present a study that attempts to calculate the potential strain coverage of this vaccine.in Europe Invasive MenB strains isolated mainly in the most recent full epidemiological year in England and Wales, France, Germany, Italy, and Norway were assessed. To investigate whether generalisation of cov...
Source: NeLM - News - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

NICE issues Appraisal Consultation Document on ruxolitinib (Jakavi) for treatment of splenomegaly and symptoms linked to myelofibrosis
Source: NICE Area: News NICE has issued new draft guidance not recommending ruxolitinib (Jakavi), for the treatment of disease-related splenomegaly (enlarged spleen) or symptoms in adults with primary myelofibrosis, or myelofibrosis secondary to polycythaemia vera or essential thrombocythaemia. The Committee noted that ruxolitinib was effective in reducing spleen size and in treating symptoms, such as itch and fatigue; and although it was plausible that ruxolitinib could offer a survival benefit, there were uncertainties in the data used by the manufacturer to estimate the degree of survival benefit. The Eviden...
Source: NeLM - News - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

Shortage of isosorbide mononitrate 10mg, 20mg and 40mg tablets
Source: Department of Health (DH) Area: News The Department of Health has issued a letter highlighting a current shortage of all normal release isosorbide mononitrate presentations (10, 20 and 40mg tablets) because of problems with the availability of raw materials. The shortage of this medicine may last for several months and current information indicates that normal supply is unlikely to resume before the end of April 2013. However, the situation may change from week to week, as it is understood that some companies may obtain some stock before that time, while others are importing unlicensed isosorbide mononi...
Source: NeLM - News - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

Anti-vascular endothelial growth factor for macular oedema secondary to branch retinal vein
Source: Cochrane Area: Evidence > Drug Class Focused Reviews Background Branch retinal vein occlusion (BRVO) is one of the most common occurring retinal vascular abnormalities. The pathogenesis of BRVO is thought to involve both retinal vein compression and damage to the vessel wall, possibly leading to thrombus formation at sites where retinal arterioles cross retinal veins. The most common cause of visual loss in patients with BRVO is macular oedema (MO). Grid or focal laser photocoagulation has been shown to reduce the risk of visual loss and improve visual acuity (VA) in up to two thirds of individuals with MO s...
Source: NeLM - Drug Class Focused Reviews - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

Intramuscular versus intravenous anti-D for preventing Rhesus alloimmunization during pregnancy
Source: Cochrane Area: Evidence > Drug Class Focused Reviews Background Antibodies to the red cell Rhesus D (RhD) antigen can be produced during pregnancy in a RhD-negative mother carrying a RhD-positive fetus, in particular following feto-maternal haemorrhage at birth or following any procedure that may cause feto-maternal haemorrhage. While the first baby is usually not harmed, these antibodies may cause haemolytic disease of the fetus/newborn (HDFN) in subsequent RhD-positive babies. RhD incompatibility is a major cause of HDFN. To reduce the risk of HDFN, anti-D is given to RhD-negative mothers at 28 ...
Source: NeLM - Drug Class Focused Reviews - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

Human chorionic gonadotrophin (hCG) for preventing miscarriage
Source: Cochrane Area: Evidence > Drug Specific Reviews Background Recurrent miscarriage (RM) is defined as the loss of three or more consecutive pregnancies. Further research is required to understand the causes of RM, which remain unknown for many couples. Human chorionic gonadotrophin (hCG) is vital for maintaining the corpus luteum, but may have additional roles during implantation which support its use as a therapeutic agent for RM. Objectives To determine the efficacy of hCG in preventing further miscarriage in women with a history of unexplained RM. Search methods We sear...
Source: NeLM - Drug Specific Reviews - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

Thyroid hormones for acute kidney injury
Source: Cochrane Area: Evidence > Drug Specific Reviews Background Acute kidney injury (AKI), which is common in hospitalised patients, is associated with significant morbidity and mortality. Despite recent advances in treatment, AKI outcomes have not changed substantially during the past four decades, and incidence is increasing. There is an urgent need to explore novel therapeutic agents and revisit some older drugs to review their roles in the management of AKI. Although thyroid hormone therapy has shown promise in experimental animal studies, clinical efficacy and safety have not been systematically assessed for...
Source: NeLM - Drug Specific Reviews - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

Tranexamic acid for reducing mortality in emergency and urgent surgery
Source: Cochrane Area: Evidence > Drug Specific Reviews Background Emergency or urgent surgery, which can be defined as surgery which must be done promptly to save life, limb, or functional capacity, is associated with a high risk of bleeding and death. Antifibrinolytic agents, such as tranexamic acid, inhibit blood clot breakdown (fibrinolysis) and can reduce perioperative bleeding. Tranexamic acid has been shown to reduce the need for a blood transfusion in adult patients undergoing elective surgery but its effects in patients undergoing emergency or urgent surgery is unclear. Objectives To assess ...
Source: NeLM - Drug Specific Reviews - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

NATURCOKSINUM AM PM REAL RELIEF (Anas Barbariae, Chamomilla, Coffea Cruda) Kit [HOMEOLAB USA INC]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

CLEARSKIN PROFESSIONAL OIL FREE (Octinoxate, Octisalate, Oxybenzone, Avobenzone) Lotion [Avon Products, Inc.]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

ATORVASTATIN CALCIUMtablet, Film Coated [Bryant Ranch Prepack]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

ZIPRASIDONE HYDROCHLORIDEcapsule [REMEDYREPACK INC. ]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

HEALTH MART OMEPRAZOLE (Omeprazole) Tablet, Delayed Release [McKesson]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

GIVENCHY TEINT COUTURE LONG WEARING FLUID FOUNDATION WITH SUNSCREEN BROAD SPECTRUM SPF 20 ELEGANT HONEY (Titanium Dioxide) Liquid [LVMH Fragrance Brands]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

LANSOPRAZOLEcapsule, Delayed Release [Bryant Ranch Prepack]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

SLEEP AID (Diphenhydramine Hcl) Tablet [Navarro Discount Pharmacies,LLC]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

AMLODIPINE BESYLATE AND BENAZEPRIL HYDROCHLORIDE (Amlodipine Besylate And Benazepril Hydrochloride) Capsule [Bryant Ranch Prepack]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

CLEARSKIN PROFESSIONAL DAILY CORRECTING (Salicylic Acid) Lotion [Avon Products, Inc.]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

BACTI-STAT (Triclosan) Solution [Ecolab Inc.]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

OPAHL DYE FREE (Benzocaine) Gel [Dharma Research, Inc.]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

G1621 ANAEROBIC PULSATOR ARTERIAL BLOOD SAMPLING KIT WITH LIQUID SODIUM HEPARIN FOR GASES AND ELECTROLYTES () Kit [Smiths Medical ASD, Inc.]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

CHILDRENS COUGH SYMPTOM FORMULA (Aconitum Napellus, Bromium, Coccus Cacti, Corallium Rubrum, Cuprum Metallicum, Drosera, Hepar Sulphuris Calcareum, Iodium, Mephitis Mephitica And Spongia Tosta) Liquid [King Bio Inc.]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

PROCHLORPERAZINE MALEATEtablet, Film Coated [Lake Erie Medical DBA Quality Care Products LLC]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

FOSINOPRIL SODIUMtablet [Physicians Total Care, Inc.]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

DAILY MOISTURIZING (Dimethicone) Lotion [Your Military Exchanges]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

MAFENIDE ACETATEpowder, For Solution [Par Pharmaceutical Companies, Inc.]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

PANTOPRAZOLE SODIUMtablet, Delayed Release [Unit Dose Services]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

LAURA MERCIER TINTED MOISTURIZER CREME COMPACT BROAD SPECTRUM SPF 20 SUNSCREEN NATURAL (Avobenzone, Octisalate, Octocrylene) Cream [Gurwitch Products, LLC]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

PREMIER VALUE ARTHRITIS PAIN RELIEVER (Acetaminophen) Tablet, Extended Release [Premier Value]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

ANTI-ITCH (Diphenhydramine Hcl) Gel [Navarro Discount Pharmacies,LLC]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

PARCOPA (Carbidopa And Levodopa) Tablet, Orally Disintegrating [Jazz Pharmaceuticals, Inc.]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

FLEET (Sodium Phosphate, Dibasic And Sodium Phosphate, Monobasic) Enema [C.B. Fleet Company, Inc.]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

MIRALAX (Polyethylene Glycol 3350) Powder, For Solution [MSD Consumer Care, Inc.]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

CLEARING TONIC (Salicylic Acid) Liquid [Halogent, LLC (DBA Exposed Skin Care) ]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

ALLERGY RELIEF (Diphenhydramine Hcl) Tablet [Navarro Discount Pharmacies,LLC]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

COPPERTONE SPORT SUNSCREEN SPF 30 (Homosalate, Octisalate, Octinoxate, And Oxybenzone) Stick [MSD Consumer Care, Inc.]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news

PROTECTOR SPF 15 JAFRA SUN (Avobenzone, Homosalate, Octisalate, Oxybenzone) Stick [Jafra Cosmetics International Inc]
Updated Date: Feb 14, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 14, 2013 Category: Drugs & Pharmacology Source Type: news