Drugs & Pharmacology 
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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 33.
Online training and brochure for stroke care teams launched
Source: Wessex HIEC Partnership
Area: News
Wessex HIEC in collaboration with the University of Central Lancashire has launched an online training package for professionals involved in stroke care. The clinical leads forum has also developed a brochure for patients and their families to understand more about the condition and information specific to their own care.
Please see link for details.
Source: NeLM - News - February 19, 2013 Category: Drugs & Pharmacology Source Type: news
Allied Health Professionals Bulletin published - February 2013
Source: NHS Networks
Area: News
The February edition of the Allied Health Professionals Bulletin has been published. This edition has information on NHS Change Day 2013, NICE guidance on local formularies, training opportunities and service redesign and improvement.
Please see link for details.
Source: NeLM - News - February 19, 2013 Category: Drugs & Pharmacology Source Type: news
Prescribing tool launched
Source: E-Health Insider
Area: News
According to a report by E-Health Insider, the University of Nottingham has developed the PINCER Query Library which is now available for all GP practices in England. The programme is a prescribing safety audit tool based on the outcomes of the PINCER Trial (a pharmacist led, IT based, intervention aimed at improving the safety of prescribing in general practice).
Please see link for details on acquiring the programme.
Source: NeLM - News - February 19, 2013 Category: Drugs & Pharmacology Source Type: news
Aston University research gives insights into medicines adherence problems
Source: Aston University
Area: News
The Medicines Research Unit at Aston University has announced the results of a study aimed at establishing the extent of non-adherence to prescribed medication within the adult population of the Heart of Birmingham teaching Primary Care Trust (HoBtPCT) within four treatment groups - dyslipidaemia, type 2 diabetes, hypothyroidism, and prophylaxis of thrombosis.
For the study, more than one million anonymised individual prescription issues were analysed, and just over 7,000 patient questionnaires were administered, in two mailings. Seven focus groups were conducted and a full r...
Source: NeLM - News - February 19, 2013 Category: Drugs & Pharmacology Source Type: news
RCT: Acupuncture in patients with seasonal allergic rhinitis
Source: Ann Intern Med
Area: News
The Annals of Internal Medicine has featured the results of a randomised controlled trial evaluating the efficacy of acupuncture in the management of seasonal allergic rhinitis (SAR).
The multicentre trial involved patients seen at 6 hospital clinics and 32 private outpatient clinics. A total of 422 persons with SAR and IgE sensitisation to birch and grass pollen were recruited, and patients were randomised to receive one of the following three treatment arms:
. Acupuncture plus rescue medication (RM) (cetirizine) (n = 212)
. Placebo acupuncture with RM (...
Source: NeLM - News - February 19, 2013 Category: Drugs & Pharmacology Source Type: news
Systematic Review: Comparative effectiveness of treatments for open-angle glaucoma
In conclusion, the researchers report that medical and surgical treatments for open-angle glaucoma ...
Source: NeLM - News - February 19, 2013 Category: Drugs & Pharmacology Source Type: news
Reporting on Adverse Clinical Events
Source: Clin-Alert - February 19, 2013 Category: Drugs & Pharmacology Tags: Articles Source Type: research
Pharmacology Continuing Education Posttest
Source: Journal of Pediatric Health Care - February 18, 2013 Category: Pediatrics Authors: Teri Moser Woo, James R. Hanley Tags: Pharmacology Continuing Education Source Type: research
“How High Do They Look?”: Identification and Treatment of Common Ingestions in Adolescents
Abstract: Adolescents have access to a variety of legal or illicit substances that they use to alter their mood or “get high.” The purpose of this review is to provide an overview of common substances adolescents use to get high, including the illicit substances synthetic marijuana or “Spice,” salvia, MDMA, synthetic cathinones, and 2C-E. Dextromethorphan and energy drinks are easily accessible substances that teenagers abuse. The toxic effects of common ingestions and treatment of overdose is discussed to inform pediatric providers who provide care for adolescents.
Source: Journal of Pediatric Health Care - February 18, 2013 Category: Pediatrics Authors: Teri Moser Woo, James R. Hanley Tags: Pharmacology Continuing Education Source Type: research
Involvement Of Large‐Conductance Ca2+‐Activated K+ Channels In Both Nitric Oxide And Endothelium‐Derived Hyperpolarization‐Type Relaxation In Human Penile Small Arteries
This study was designed to investigate the involvement of BKCa channels in endothelium‐dependent and ‐independent relaxation of human intracavernous penile arteries. In human intracavernous arteries obtained in connection with transsexual operations, change of isometric force was recorded in microvascular myographs and endothelium‐dependent (nitric oxide (NO) and endothelium‐derived hyperpolarization (EDH)‐type) and ‐independent (NO‐donor) relaxation was measured in contracted arteries. In penile small arteries contracted with phenylephrine, acetylcholine evoked NO‐ and EDH‐type relaxations which were sen...
Source: Basic and Clinical Pharmacology and Toxicology - February 18, 2013 Category: Drugs & Pharmacology Authors: István Király, János Pataricza, Zoltán Bajory, Ulf Simonsen, András Varro, Julius Gy. Papp, Lászlo Pajor, Attila Kun Tags: Original Article Source Type: research
Retaining Antibodies in
Tumors with a Self-Assembling
Injectable System
Molecular PharmaceuticsDOI: 10.1021/mp300504z
Source: Molecular Pharmaceutics - February 18, 2013 Category: Drugs & Pharmacology Authors: Yi Wen, Harold R. Kolonich, Kristen M. Kruszewski, Nick Giannoukakis, Ellen S. Gawalt and Wilson S. Meng Source Type: research
Outcomes data for use of Humira (Adalimumab) in patients with paediatric Crohn's disease
AbbVie (NYSE:ABBV) has announced the first long-term, patient-reported health outcomes data from analyses of the Phase 3 IMAgINE-1 trial.
Source: Pharmacy Europe - February 18, 2013 Category: Drugs & Pharmacology Source Type: news
Infiltration of M1 macrophages into adipose tissue of ddY-H mice preceding spontaneous appearances of insulin resistance.
Abstract
We have isolated insulin resistant mice (ddY-H mice) which are spontaneously induced at 12-weeks of age even if fed with the standard chow pellets. Since accumulated evidences have suggested that an appearance of insulin resistance is associated with obesity and a state of inflammation in adipose tissue, the present study investigated an appearance of macrophages in adipose tissue of ddY-H mice. Although ddY-H mice were fed the standard chow pellets ad lib, increases in body weight, adipose tissue mass, and fat cell size were observed. In adipose tissues of ddY-H mice, gene expression of monocyte chemoattr...
Source: Biological and Pharmaceutical Bulletin - February 18, 2013 Category: Drugs & Pharmacology Authors: Maeda T, Noge I, Kagawa Y Tags: Biol Pharm Bull Source Type: research
Effects of Phosphate Buffer in Parenteral Drugs on Particle Formation from Glass Vials.
Abstract
The characteristics of inorganic particles generated in glass vials filled with phosphate buffer solutions were investigated. During storage, particles were visually detected in the phosphate buffer solution in particular glass vials which pass compendial tests of containers for injectable drugs. These particles were considered to be different from ordinal glass delamination, which has been reported in a number of papers because the particles were mainly composed of Al, P and O, but not Si. The formation of the particles accelerated at higher storage temperatures. Among the surface treatments tested for th...
Source: Chemical and Pharmaceutical Bulletin - February 18, 2013 Category: Drugs & Pharmacology Authors: Ogawa T, Miyajima M, Wakiyama N, Terada K Tags: Chem Pharm Bull (Tokyo) Source Type: research
Biochemical Properties and Comparative Pharmacology of A Coagulant from Deinagkistrodon acutus Snake Venom.
Abstract
A number of snake venom thrombin-like enzymes (TLEs) have already been characterized. Some TLEs play significant roles in vessel injury hemostasis. A novel TLE (Agacutase) was purified from Deinagkistrodon acutus snake venom by the means of Sephadex G-75, DEAE-Sepharose FF, and Sephadex G-25 column chromatography. Structural analysis indicated that Agacutase is a single-chain glycoprotein with a molecular mass of 31,084 Da, isoelectric point of 4.38, optimal activity at 37°C and pH 6.6, sugar content of 7.6%. Its N-terminal 44 amino acid sequence was determined to be VIGGNECDTNEHRFLAAFFTSRPWIFQCAGTLIHEEWV...
Source: European Journal of Pharmaceutical Sciences - February 18, 2013 Category: Drugs & Pharmacology Authors: Tang SS, Wang XH, Zhang JH, Tang BS, Qian L, Li PY, Luo LW Tags: Eur J Pharm Sci Source Type: research
Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice.
Abstract
Crocetin, an aglycone of crocin, is found both in the saffron crocus (Crocus starus L.) and in gardenia fruit (Gardenia jasminoides Ellis). We evaluated the protective effects of crocetin against the retinal ischemia induced by 5h unilateral ligation of both the pterygopalatine artery (PPA) and the external carotid artery (ECA) in anesthetized mice. The effects of crocetin (20mg/kg, p.o.) on ischemia/reperfusion-induced retinal damage were examined by histological, electrophysiological, and anti-apoptotic analyses. Data for anti-apoptopic analysis was obtained by terminal deoxynucleotidyl transferase dUTP ...
Source: European Journal of Pharmacology - February 18, 2013 Category: Drugs & Pharmacology Authors: Ishizuka F, Shimazawa M, Umigai N, Ogishima H, Nakamura S, Tsuruma K, Hara H Tags: Eur J Pharmacol Source Type: research
Rebamipide inhibits indomethacin-induced small intestinal injury: Possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5.
In conclusion, our study results suggest that rebamipide inhibited indomethacin-induced small intestinal injuries, possibly by modulating the bacterial flora in the small intestine by upregulation of α-defensin 5.
PMID: 23428631 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - February 18, 2013 Category: Drugs & Pharmacology Authors: Tanigawa T, Watanabe T, Otani K, Nadatani Y, Ohkawa F, Sogawa M, Yamagami H, Shiba M, Watanabe K, Tominaga K, Fujiwara Y, Takeuchi K, Arakawa T Tags: Eur J Pharmacol Source Type: research
Endothelial cell response to (co)polymer nanoparticles depending on the inflammatory environment and comonomer ratio.
Abstract
Endothelial cells lining the lumen of blood vessels serve as a physiological barrier controlling nanoparticle movement from the vasculature into the tissue. For exploring the effect of polymer hydrophilicity on nanoparticle interactions with human umbilical vein endothelial cells (HUVEC) in vitro, a series of monomodal poly[acrylonitrile-co-(N-vinylpyrrolidone)] model nanoparticles with increasing hydrophilicity as related to their increasing content (0-30 mol.%) of N-vinylpyrrolidone (NVP) were synthesized by miniemulsion polymerization. Nanoparticles with a low NVP content were rapidly endocytized into a...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 18, 2013 Category: Drugs & Pharmacology Authors: Wischke C, Krüger A, Roch T, Pierce BF, Li W, Jung F, Lendlein A Tags: Eur J Pharm Biopharm Source Type: research
Aminolevulinic acid derivatives-based photodynamic therapy in human intra- and extrahepatic cholangiocarcinoma cells.
Abstract
Hexyl-aminolevulinic acid (HALA) was compared with aminolevulinic acid (ALA) in terms of improving ALA-based photodynamic therapy (PDT) for human intra- and extrahepatic cholangiocarcinoma (CCA) HuCC-T1 and SNU1196 cells. Because of the different uptake mechanisms of HALA, a relatively higher amount of protoporphyrin IX (PpIX) was induced in the both CCA cell types at low concentrations of HALA. Furthermore, higher expression of porphobilinogen deaminase, coproporphyrinogen III oxidase, and protoporphyrinogen oxidase, the key enzymes for synthesizing PpIX in the heme biosynthetic pathway, facilitated the e...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 18, 2013 Category: Drugs & Pharmacology Authors: Chung CW, Kim CH, Lee HM, Kim DH, Kwak TW, Chung KD, Jeong YI, Kang DH Tags: Eur J Pharm Biopharm Source Type: research
A Novel Oromucosal Prolonged Release Mucoadhesive Suspension by One Step Spray Coagulation Method.
Abstract
An oromucosal mucoadhesive suspension (OMS) able to combine the peculiarities of prolonged release mucoadhesive microparticles with those of an immediate release oromucosal solution is described. Microparticles were obtained by ionotropic gelation of alginate blended with another mucoadhesive material in a one step process where the cross-linking bath constituted the suspension vehicle. The effects of formulation and processing conditions on OMS performances were measured in-vitro determining the enhancement of drug penetration in buccal porcine mucosa and inhibition of tooth plaque formation using flurbip...
Source: Current Drug Delivery - February 18, 2013 Category: Drugs & Pharmacology Authors: Cilurzo F, Gennari CG, Selmin F, Musazzi UM, Rumio C, Minghetti P Tags: Curr Drug Deliv Source Type: research
On-chip Investigation of Cell-drug Interactions.
Abstract
Investigation of cell-drug interaction is of great importance in drug discovery but continues to pose significant challenges to develop robust, fast and high-throughput methods for pharmacologically profiling of potential drugs. Recently, cell chips have emerged as a promising technology for drug discovery/delivery, and their miniaturization and flow-through operation significantly reduce sample consumption while dramatically improving the throughput, reliability, resolution and sensitivity. Herein we review various types of miniaturized cell chips used in investigation of cell-drug interactions. The desig...
Source: Advanced Drug Delivery Reviews - February 18, 2013 Category: Drugs & Pharmacology Authors: Zheng XT, Yu L, Li P, Dong H, Wang Y, Liu Y, Li CM Tags: Adv Drug Deliv Rev Source Type: research
Medical therapy of coronary artery disease after percutaneous intervention.
Abstract
Medical therapy following percutaneous coronary intervention aims at preventing first, coronary disease progression and its clinical manifestations, and finally, the two main complications of coronary stenting, stent thrombosis and restenosis. Prevention of in-stent restenosis is restricted to local drug delivery in the form of drug eluting stents (DES). Second generation DES have improved their efficacy and safety profile by innovations in drug coating, the polymer drug-delivery system and stent design. The mainstay of stent thrombosis prevention remains dual anti-platelet therapy with acetylsalicylic aci...
Source: Current Opinion in Pharmacology - February 18, 2013 Category: Drugs & Pharmacology Authors: Kurz DJ, Eberli FR Tags: Curr Opin Pharmacol Source Type: research
Targeting mechanotransduction pathways in osteoarthritis: a focus on the pericellular matrix.
Abstract
Mechanical joint loading is an essential factor in joint homeostasis but it is also the most important aetiological factor in the development of osteoarthritis (OA). Although OA has long been regarded a disease of 'wear and tear', data arising from studies over the past 10 years have put pay to a mechanical 'attrition' theory of OA and place the induction and activation of specific matrix degrading enzymes centrally in the disease process. The finding that these enzymes are induced in vivo in a mechanosensitive manner provides a clear and sensible unifying hypothesis for disease pathogenesis; namely that m...
Source: Current Opinion in Pharmacology - February 18, 2013 Category: Drugs & Pharmacology Authors: Vincent TL Tags: Curr Opin Pharmacol Source Type: research
An Update of Radiolabeled Bombesin Analogues for Gastrin-Releasing Peptide Receptor Targeting.
Abstract
Prostate cancer is a critical public health problem in USA and Europe. New non-invasive imaging methods are urgently needed, due to the low accuracy and specificity of current screen methods and the desire of localizing primary prostate cancer and bone metastasis. Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) are the non-invasive and sensitive imaging methods which have been widely used for diagnosing diseases in the clinic. Lack of suitable radiotracers is the major issue for nuclear imaging of prostate cancer, although radiolabeled bombesin (BN) peptides target...
Source: Current Pharmaceutical Design - February 18, 2013 Category: Drugs & Pharmacology Authors: Yu Z, Ananias HJ, Carlucci G, Hoving HD, Helfrich W, Dierckx RA, Wang F, de Jong IJ, Elsinga PH Tags: Curr Pharm Des Source Type: research
Discovery of a new small-molecule inhibitor of p53-MDM2 interaction using a yeast-based approach.
Abstract
The virtual screening of a library of xanthone derivatives led us to the identification of potential novel MDM2 ligands. The activity of these compounds as inhibitors of p53-MDM2 interaction was investigated using a yeast phenotypic assay, herein developed for the initial screening. Using this approach, in association with a yeast p53 transactivation assay, the pyranoxanthone (3,4-dihydro-12-hydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one) (1) was identified as a putative small-molecule inhibitor of p53-MDM2 interaction. The activity of the pyranoxanthone 1 as inhibitor of p53-MDM2 interaction was fu...
Source: Biochemical Pharmacology - February 18, 2013 Category: Drugs & Pharmacology Authors: Leão M, Pereira C, Bisio A, Ciribilli Y, Paiva A, Machado N, Palmeira A, Fernandes MX, Sousa E, Pinto M, Inga A, Saraiva L Tags: Biochem Pharmacol Source Type: research
Oxysterol-binding proteins: Functions in cell regulation beyond lipid metabolism.
Abstract
Oxysterol-binding (OSBP)-related proteins (ORPs) constitute a family of sterol and phosphoinositide binding/transfer proteins in eukaryotes from yeast to man. While their functions have mainly been addressed in cellular lipid metabolism or sterol transport, increasing evidence points to more versatile regulatory roles in a spectrum of cellular regimes. In fact ORPs do not appear to be robust controllers of lipid homeostasis. Several ORPs localize at membrane contacts sites (MCS), where endoplasmic reticulum (ER) is apposed with other organelle limiting membranes. Apparently, ORPs have the capacity to contr...
Source: Biochemical Pharmacology - February 18, 2013 Category: Drugs & Pharmacology Authors: Weber-Boyvat M, Zhong W, Yan D, Olkkonen VM Tags: Biochem Pharmacol Source Type: research
Diabetes research in Vascular Pharmacology - an overview of 2011-2012.
PMID: 23428913 [PubMed - as supplied by publisher]
Source: Vascular Pharmacology - February 18, 2013 Category: Drugs & Pharmacology Authors: Caterina RD Tags: Vascul Pharmacol Source Type: research
Biotransformation of trans-1-chloro-3,3,3-trifluoropropene (trans-HCFO-1233zd).
Abstract
trans-1-Chloro-3,3,3-trifluoropropene (trans-HCFO-1233zd) is a novel foam blowing and precision cleaning agent with a very low impact for global warming and ozone depletion. trans-HCFO-1233zd also has a low potential for toxicity in rodents and is negative in genotoxicity testing. The biotransformation of trans-HCFO-1233zd and kinetics of metabolite excretion with urine were assessed in vitro and in animals after inhalation exposures. For in vitro characterization, liver microsomes from rats, rabbits and humans were incubated with trans-HCFO-1233zd. Male Sprague Dawley rats and female New Zealand White rab...
Source: Toxicology and Applied Pharmacology - February 18, 2013 Category: Toxicology Authors: Schmidt T, Bertermann R, Rusch GM, Tveit A, Dekant W Tags: Toxicol Appl Pharmacol Source Type: research
Information resource for care workers on infection prevention and control in care homes
Source: Department of Health
Area: News
The Department of Health has published an information resource and summary for care workers on the prevention and control of infection in care homes. The aim of these documents is to assist staff in taking all reasonable steps to protect residents and staff from acquiring infections and cross infection; and provide information and guidance on infection prevention and control that will assist managers undertaking risk assessments and in developing policies.
Please see the links below for details.
Source: NeLM - News - February 18, 2013 Category: Drugs & Pharmacology Source Type: news
Study investigates minocycline pleurodesis for primary spontaneous pneumothorax
Source: Lancet
Area: News
According to the results of an open-label RCT conducted in Taiwan, the use of minocycline pleurodesis after simple aspiration is safe and more effective than simple aspiration and drainage only in the treatment for primary spontaneous pneumothorax.
The authors note that simple aspiration and drainage is a standard initial treatment for primary spontaneous pneumothorax. However there is a high rate of recurrence, and they therefore sought to investigate the adjunctive use of minocycline pleurodesis in this setting. The study, conducted at two hospitals in Taiwan, included 214 pati...
Source: NeLM - News - February 18, 2013 Category: Drugs & Pharmacology Source Type: news
Therapeutics: Newer non-oral hormonal contraception
This article forms one of a series of occasional articles published in the BMJ on therapeutics for common or serious conditions, covering new drugs and old drugs with important new indications or concerns. The current article focuses on newer non-oral hormonal contraception and the following topics are discussed:
. What newer non-oral hormonal contraceptive methods are available? . How well do these methods work? . How safe are these methods? . What are the precautions? . How are they taken and monitored? . How do these methods compare with other methods? . How cost effective a...
Source: NeLM - News - February 18, 2013 Category: Drugs & Pharmacology Source Type: news
Systematic review and meta-analysis finds newer hydroxyethyl starch to be of no overall clinical benefit in sepsis
Source: British Medical Journal (BMJ)
Area: News
According to the results of a systematic review and meta-analysis, treatment of sepsis with newer hydroxyethyl starches increases the risk of having renal replacement therapy, red blood cell transfusion, and severe adverse reactions when compared to crystalloids or human albumin, and is therefore unlikely to be of benefit for this patient group.
The authors note that colloids are used more often than crystalloids for resuscitation in the intensive care unit (ICU). Although the choice of colloid varies between countries, hydroxyethyl starch is most commonly used w...
Source: NeLM - News - February 18, 2013 Category: Drugs & Pharmacology Source Type: news
Draft NICE guidance recommends use of Oncotype DX to guide early breast cancer treatment decisions
Source: NICE
Area: News
NICE has issued its third diagnostics consultation on gene expression profiling and expanded immunohistochemistry (protein expression profiling) tests to guide the use of adjuvant chemotherapy in early breast cancer management (MammaPrint, Oncotype DX, IHC4 and Mammostrat). These tests measure multiple markers within the tumour that may indicate how the tumour is likely to develop. This third consultation follows consultations on previous drafts and the submission of a confidential access proposal by the manufacturer of Oncotype DX.
The draft guidance recommends the use of Oncotype DX in...
Source: NeLM - News - February 18, 2013 Category: Drugs & Pharmacology Source Type: news
In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice
Conclusions:
Exposure to arsenic at the current WHO maximum contaminant level in utero impaired somatic growth and the development of the lungs resulting in alterations to lung mechanics during infancy. Deficits in growth and lung development in early life may contribute to the increased susceptibility of developing chronic respiratory disease in arsenic exposed human populations.
Source: BMC Clinical Pharmacology - February 18, 2013 Category: Drugs & Pharmacology Authors: Kathryn RamseyAlexander LarcombePeter SlyGraeme Zosky Source Type: research
Screening of potential pseudo att sites of Streptomyces phage ΦC31 integrase in the human genome.
Conclusion:The results provide clues for more comprehensive evaluation of the risks of using ΦC31 integrase in human gene therapy and for drug discovery.
PMID: 23416928 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - February 18, 2013 Category: Drugs & Pharmacology Authors: Hu ZP, Chen LS, Jia CY, Zhu HZ, Wang W, Zhong J Tags: Acta Pharmacol Sin Source Type: research
Advanced glycation end products promote human aortic smooth muscle cell calcification in vitro via activating NF-κB and down-regulating IGF1R expression.
Conclusion:The results demonstrate that AGEs promote calcification of human aortic smooth muscle cells in vitro via activation of NF-κB and down-regulation of IGF1R expression.
PMID: 23416929 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - February 18, 2013 Category: Drugs & Pharmacology Authors: Wang Y, Zhang ZY, Chen XQ, Wang X, Cao H, Liu SW Tags: Acta Pharmacol Sin Source Type: research
Autophagy in ageing and ageing-associated diseases.
Abstract
Autophagy is a cell self-digestion process via lysosomes that clears "cellular waste", including aberrantly modified proteins or protein aggregates and damaged organelles. Therefore, autophagy is considered a protein and organelle quality control mechanism that maintains normal cellular homeostasis. Dysfunctional autophagy has been observed in ageing tissues and several ageing-associated diseases. Lifespan of model organisms such as yeast, worms, flies, and mice can be extended through promoting autophagy, either by genetic manipulations such as over-expression of Sirtuin 1, or by administrations of rapamy...
Source: Acta Pharmacologica Sinica - February 18, 2013 Category: Drugs & Pharmacology Authors: He LQ, Lu JH, Yue ZY Tags: Acta Pharmacol Sin Source Type: research
Independent review invites public to share their experiences of the Liverpool Care Pathway
Source: Department of Health
Area: News
Members of the public are being invited to share their experiences of the Liverpool Care Pathway for Dying Patients (LCP). This will form part of the independent review of the pathway, which is due to report to ministers and to the NHS Commissioning Board in the summer.
For further information about the review, please see the links below.
Source: NeLM - News - February 18, 2013 Category: Drugs & Pharmacology Source Type: news
Local Authorities - Health and Wellbeing Boards and Health Scrutiny Regulations
Source: Department of Health
Area: News
The Local Authority (Public Health, Health and Wellbeing Boards and Health Scrutiny) Regulations 2013 have now been published, providing a step forward in enabling local authorities to finalise local preparations for health and wellbeing boards and health scrutiny arrangements.
Please see the link below for details.
Source: NeLM - News - February 18, 2013 Category: Drugs & Pharmacology Source Type: news
Third case of novel coronavirus infection identified in family cluster
Source: Health Protection Agency (HPA)
Area: News
The Health Protection Agency (HPA) has confirmed a third case of novel coronavirus infection in a family cluster, following the confirmed diagnosis of two cases announced over the past week. The patient, who is a UK resident and does not have any recent travel history, is recovering from a mild respiratory illness and is currently well. This latest case brings the total number of confirmed cases globally to 12, of which four have been diagnosed in the UK.
Source: NeLM - News - February 18, 2013 Category: Drugs & Pharmacology Source Type: news
Overview of responses to NHS Constitution consultation published
Source: Department of Health (DH)
Area: News
The government has published a report providing an overview of responses to the consultation on strengthening the NHS Constitution, which ran from 28 November 2012 to 28 January 2013 and received over 350 responses. The report sets out changes to the guiding 'Principles of the NHS Constitution'; regulations to change these principles will be laid before Parliament shortly. The updated constitution is expected to be published by April 2013.
Source: NeLM - News - February 18, 2013 Category: Drugs & Pharmacology Source Type: news
NHS Choices 'Behind the Headlines' article on the horsemeat investigation
Source: NHS Choices
Area: News
The 'Behind the Headlines' service from NHS Choices has featured an article discussing the concerns that have been raised about the safety of horsemeat, following an announcement from the Food Standards Agency (FSA) that it detected the presence of phenylbutazone ('bute') in horses slaughtered in the UK.
The assessment discusses the following:
. What is the background to the story? . What is 'bute'? . What are officials doing about the horsemeat contamination? . What is phenylbutazone? . Why is phenylbutazone banned? . What should I do if I...
Source: NeLM - News - February 18, 2013 Category: Drugs & Pharmacology Source Type: news
NHS Choices 'Behind the Headlines' assessment: Smoking bans may help cut premature births
Source: NHS Choices
Area: News
The 'Behind the Headlines' service from NHS Choices has featured a quality assessment of a BBC News headline: "Smoking ban 'cuts premature births'" (February 15th 2013). The report was based on research published in the BMJ which looked at recorded premature birth trends in Belgium around the time of a public smoking ban there. Although this is not directly comparable to the bans in the UK countries, the assessment states that Belgium is a useful example to look at as they introduced public smoking bans in stages between 2006 and 2010.
The assessment discusses the research, its ba...
Source: NeLM - News - February 18, 2013 Category: Drugs & Pharmacology Source Type: news
Horizon scanning: Phase III data for eliglustat for Gaucher disease type 1
Source: BioSpace
Area: News
BioSpace has reported on new Phase III data for eliglustat tartrate, an investigational oral therapy for Gaucher disease type 1.
The randomised, double-blind, placebo-controlled ENGAGE study evaluated the safety and efficacy of eliglustat tartrate in 40 treatment-naïve patients with Gaucher disease type 1. The primary endpoint was spleen size - spleen volume decreased by a mean of 28% in patients treated with eliglustat tartrate and increased by a mean of 2% in those treated with placebo (p<0.0001). Improvements in a number of secondary endpoints (e.g. platelet levels) were als...
Source: NeLM - News - February 18, 2013 Category: Drugs & Pharmacology Source Type: news
Russian Meteorite Recalls 1934 Farmville, North Carolina Fireball
Although I'm trained as a pharmacologist, my current science communications position at the North Carolina Museum of Natural Sciences demands that I learn about all manner of sciences. The job gives me no choice but to regain my childlike enthusiasm for the natural world.
Source: Forbes.com Healthcare News - February 17, 2013 Category: Pharmaceuticals Authors: David Kroll Source Type: news
Paeonol suppresses lipopolysaccharide‐induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock
In this study, we primarily investigated the anti‐inflammatory effects and the underlying mechanisms of paeonol in RAW macrophage cells; and based on these effects, we assessed the protective effects of paeonol on lipopolysaccharide‐induced endotoxemia in mice. The in vitro study showed that paeonol regulated the production of TNF‐α, IL‐1β, IL‐6, and IL‐10 via inactivation of IκBα, ERK1/2, JNK, and p38 MAPK. In mouse model of lipopolysaccharide‐induced endotoxemia, pro‐ and anti‐inflammatory cytokines are significantly regulated, and thus the survival rates of lipolysaccharide‐challenged mice are im...
Source: Fundamental and Clinical Pharmacology - February 17, 2013 Category: Drugs & Pharmacology Authors: Na Chen, Dianfeng Liu, Lanan Wassy Soromou, Jingjing Sun, Weiting Zhong, Weixiao Guo, Meixia Huo, Hongyu Li, Shuang Guan, Zhenwen Chen, Haihua Feng Tags: Original Article Source Type: research
Randomised clinical trial: mesalazine (Salofalk granules) for uncomplicated diverticular disease of the colon – a placebo‐controlled study
ConclusionsA daily dose of 3.0 g mesalazine may relieve pain during a symptomatic flare of uncomplicated DD. In this, the first placebo‐controlled double‐blind trial in acute uncomplicated DD, mesalazine showed promising therapeutic efficacy.
Source: Alimentary Pharmacology and Therapeutics - February 17, 2013 Category: Drugs & Pharmacology Authors: W. Kruis, E. Meier, M. Schumacher, O. Mickisch, R. Greinwald, R. Mueller, Tags: Randomised Clinical Trial Source Type: research
Topical delivery of triamcinolone via skin pretreated with ablative radiofrequency: a new method in hypertrophic scar treatment
ConclusionAblative fractional RF associated with acoustic pressure US is a new technology aiming to increase drug delivery into skin. This new method can improve the efficacy of steroids in hypertrophic scar treatment, minimizing the risks of localized atrophy and irregular appearance of the treated lesion.
Source: International Journal of Dermatology - February 17, 2013 Category: Dermatology Authors: Maria C. A. Issa, Luiza E. B. P. Kassuga, Natalia S. Chevrand, Marianna T. F. Pires Tags: Pharmacology and therapeutics Source Type: research
Protein-polyelectrolyte interactions
Soft Matter, 2013, 9,2553-2583DOI: 10.1039/C2SM27002A, Review ArticleA. Basak Kayitmazer, Daniel Seeman, Burcu Baykal Minsky, Paul L. Dubin, Yisheng XuThe interactions of proteins and polyelectrolytes lead to diverse applications in separations, delivery and wound repair, and are thus of interest to scientists in e.g. (a) glycobiology, (b) tissue engineering, (c) biosensing, and (d) pharmacology.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - February 16, 2013 Category: Chemistry Authors: A. Basak Kayitmazer Source Type: research
Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
Source: Springer Biomedical Sciences titles - February 16, 2013 Category: Biomedical Science Tags: Pharmacology / Toxicology Source Type: news
