Drugs & Pharmacology 
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This page shows you the most recent publications within this specialty of the MedWorm directory.
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High Accurate Simple Approximation of Normal Distribution Integral
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The integral of the standard normal distribution function is an integral without solution and represents
the probability that an aleatory variable normally distributed has values between zero and x. The normal distribution integral is used in several areas of science. Thus, this work provides an approximate solution to the Gaussian distribution integral by using the homotopy perturbation method (HPM). After solving the Gaussian integral by HPM, the result served as base to solve other integrals like error function and the cumulative distribution function. The error function is compared against other reported approximations...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Fungal Rhinosinusitis: A Retrospective Microbiologic and Pathologic Review of 400 Patients at a Single University Medical CenterEmail this article to a colleague.
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In this study, we evaluate the diagnosis of FRS in a single medical center. Cases were divided into 2 main categories, non-invasive and invasive. Non-invasive FRS included fungus ball (FB) and allergic fungal rhinosinusitis (AFRS). Invasive FRS included acute invasive fungal rhinosinusitis (AIFRS), chronic invasive fungal rhinosinusitis (CIFRS), and chronic invasive granulomatous fungal rhinosinusitis (CGFRS). Fungal culture data, if available was reviewed. 400 patients with FRS were identified. 87.25% were non-invasive (45% AFRS, 40% FB, and 2% combined AFRS and FB and 12.5% were invasive 11% AIFRS 1.2% CIFRS 0.5% CGFRS. ...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Energy-Efficient Multi-Job Scheduling Model for Cloud Computing and Its Genetic AlgorithmEmail this article to a colleague.
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For the problem that the energy efficiency of the cloud computing data center is low, from the point of view of the energy efficiency of the servers, we propose a new energy-efficient multi-job scheduling model based on Google’s massive data processing framework. To solve this model, we design a practical encoding and decoding method for the individuals and construct an overall energy efficiency function of the servers as the fitness value of each individual. Meanwhile, in order to accelerate the convergent speed of our algorithm and enhance its searching ability, a local search operator is introduced. Finally, the exper...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Self-Optimization of Pilot Power in Enterprise Femtocells Using Multi objective HeuristicEmail this article to a colleague.
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Deployment of a large number of femtocells to jointly provide coverage in an enterprise environment raises critical challenges especially in future self-organizing networks which rely on plug-and-play techniques for configuration. This paper proposes a multi-objective heuristic based on a genetic algorithm for a centralized self-optimizing network containing a group of UMTS femtocells. In order to optimize the network coverage in terms of handled load, coverage gaps, and overlaps, the algorithm provides a dynamic update of the downlink pilot powers of the deployed femtocells. The results demonstrate that the algorithm can ...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Occam-pi for Programming of Massively Parallel Reconfigurable ArchitecturesEmail this article to a colleague.
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We present two case-studies; DCT implementation exploiting the reconfigurability feature of
occam-pi and a significantly large autofocus criterion calculation based on the dynamic parallelism capability of the
occam-pi language. The results of the implemented case studies suggest that the occam-pi-language-based approach simplifies the
development of applications employing run-time reconfigurable devices without compromising the performance benefits. (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Subsurface Lateral Flow in Texture-Contrast (Duplex) Soils and Catchments with Shallow BedrockEmail this article to a colleague.
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Development-perched watertables and subsurface lateral flows in texture-contrast soils (duplex) are commonly believed to occur as a consequence of the hydraulic discontinuity between the A and B soil horizons. However, in catchments containing shallow bedrock, subsurface lateral flows result from a combination of preferential flow from the soil surface to the soil—bedrock interface, undulations in the bedrock topography, lateral flow through macropore networks at the soil—bedrock interface, and the influence of antecedent soil moisture on macropore connectivity. Review of literature indicates that some of these...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Arterial Microcalcifications in the Breast Mimicking MalignancyEmail this article to a colleague.
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Microcalcifications in the breast are highly suggestive of malignancy; they can occur in many pathological conditions. A 36-years-old nondiabetic woman came to the gynaecologist with a suspect palpable mass in the upper outer quadrant of the right breast. Histopathological examination confirmed a calcification of a small artery (diameter: 0.45 mm). Arterial calcifications can mimic a malignant lesion in the breast. (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Antiallodynic Effect of Herbal Medicine Yokukansan on Peripheral Neuropathy in Rats with Chronic Constriction InjuryEmail this article to a colleague.
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In this study, we investigated the effects of yokukansan on neuropathic pain in chronic constriction injury (CCI) model. Oral administration of yokukansan significantly inhibited mechanical and cold allodynia in the von Frey hair or acetone test, respectively. In comparison, amitriptyline, a tricyclic antidepressant, demonstrated moderate, but not significant, antiallodynic effects in the mechanical and cold tests. Yokukansan significantly inhibited the cerebrospinal fluid dialysate level of glutamate that had increased by the stimulation of brush or acetone. Glutamate transporter inhibitors, DL-threo-beta-hydroxy aspartat...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Aqueous Extract of Paeonia suffruticosa Inhibits Migration and Metastasis of Renal Cell Carcinoma Cells via Suppressing VEGFR-3 PathwayEmail this article to a colleague.
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In conclusion, this research elucidates the effects and molecular mechanism for antimigration of PS-A on RCC cells and suggests PS-A to be a therapeutic or adjuvant strategy for the patients with aggressive RCC. (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Economic Analysis of a Pediatric Ventilator-Associated Pneumonia Prevention Initiative in NicaraguaEmail this article to a colleague.
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We performed an economic analysis of an intervention to decrease ventilator-associated pneumonia (VAP) prevalence in pediatric intensive care units (PICUs) at two Nicaraguan hospitals to determine the cost of the intervention and how effective it needs to be in order to be cost-neutral. A matched cohort study determined differences in costs and outcomes among ventilated patients. VAP cases were matched by sex and age for children older than 28 days and by weight for infants under 28 days old to controls without VAP. Intervention costs were determined from accounting and PICU staff records. The intervention cost was approxi...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Sensitive Determination of Terazosin in Pharmaceutical Formulations and Biological Samples by Ionic-Liquid Microextraction Prior to SpectrofluorimetryEmail this article to a colleague.
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An efficient and environmentally friendly sample preparation method based on the application of hydrophobic 1-Hexylpyridinium hexafluorophosphate [Hpy][PF6] ionic liquid (IL) as a microextraction solvent was proposed to preconcentrate terazosin. The performance of the microextraction method was improved by introducing a common ion of pyridinium IL into the sample solution. Due to the presence of the common ion, the solubility of IL significantly decreased. As a result, the phase separation successfully occurred even at high ionic strength, and the volume of the settled IL-phase was not influenced by variations in the ionic...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Brainstem Infarction and Panuveitis due to Sarcoidosis Successfully Treated with Steroid Pulse TherapyEmail this article to a colleague.
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A 36-year-old man visited our hospital because of blurred vision and redness of the conjunctiva. Slit-lamp examination showed panuveitis. Two days later, he suddenly experienced dizziness, speech disturbance, paralysis of his right extremities, and gait disturbances. Neurological examinations suggested that his symptoms were caused by a left lateral medullary lesion. He also had erythema mainly on his trunk. Magnetic resonance imaging (MRI) of his brain demonstrated a small infarct on the left side of the medulla oblongata. Clinical presentation and MRI findings were consistent with the diagnosis of a Wallenberg’s syndro...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
A Rare Cause of Low Back Pain: Report of a Tailgut CystEmail this article to a colleague.
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We describe the case of a 46-year-old female who presented with a 6-month history of low back pain. CT and MRI imaging demonstrated a complex retrorectal lesion with supralevator and infralevator components. This was removed using a combined transperineal and transabdominal approach. Histology confirmed a tailgut cyst. (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
A Systematic Review of Physical Activity Interventions in Hispanic AdultsEmail this article to a colleague.
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Healthy People 2020 aims to achieve health equity, eliminate disparities, and improve the health of all groups. Regular physical activity (PA) improves overall health and fitness and has the capability to reduce risk for chronic diseases. Identifying barriers which relate to the Hispanic population is important when designing PA interventions. Therefore, the purpose was to review existing PA interventions targeting Hispanic adults published between 1988 and 2011. This paper was limited to interventions which included more than 35% Hispanic adults (n=20). Most of the interventions were community based (n=16), although clini...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
On Functions of Bounded (p,k)-VariationEmail this article to a colleague.
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We introduce and study the concept of (p,k)-variation (1<p<∞, k∈N) of a real function on a compact interval. In particular, we prove that a function u:[a,b]→R has bounded (p,k)-variation if and only if u(k-1) is absolutely continuous on [a,b] and u(k) belongs to Lp[a,b]. Moreover, an explicit connection between the (p,k)-variation of u and the Lp-norm of u(k) is given which is parallel to the classical Riesz formula characterizing functions in the spaces RVp[a,b] and Ap[a,b]. This may also be considered as an alternative characterization of the one variable Sobolev space Wpk[a,b]. (S...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Low-Level Detection of Poly(amidoamine) PAMAM Dendrimers Using Immunoimaging Scanning Probe MicroscopyEmail this article to a colleague.
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Immunoimaging scanning probe microscopy was utilized for the low-level detection and quantification of biotinylated G4 poly(amidoamine) PAMAM dendrimers. Results were compared to those of high-performance liquid chromatography (HPLC) and found to provide a vastly improved analytical method for the low-level detection of dendrimers, improving the limit of detection by a factor of 1000 (LOD=2.5×10−13 moles). The biorecognition method is reproducible and shows high specificity and good accuracy. In addition, the capture assay platform shows a promising approach to patterning dendrimers for nanotechnology...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Travel Time Model of Left-Turning Vehicles at Signalized IntersectionEmail this article to a colleague.
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The travel time of left-turning vehicles at signalized intersection was discussed. Under the assumption that the opposing through vehicles headway follows M3 distribution, the travel time model was established on the basis of gap theory and queue theory. Comparison was done with the common model based on the assumption that the opposing through vehicles headway follows negative exponential distribution. The results show that the model in this paper has stronger applicability and its most relative error is less than 15%. In addition, the sensitivity analysis was done. The results show that the opposing through flow rate...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Analysis of Delayed Bleeding after Endoscopic Submucosal Dissection for Gastric Epithelial NeoplasmsEmail this article to a colleague.
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Conclusion. Ulcer presence/absence was considered the most significant predictor of post-ESD bleeding. (Source: Advances in Pharmacological Sciences)
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Approximating Polynomials for Functions of Weighted Smirnov-Orlicz SpacesEmail this article to a colleague.
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Let G0 and G∞ be, respectively, bounded and unbounded components of a plane curve Γ satisfying Dini's smoothness condition. In addition to partial sum of Faber series of f belonging to weighted Smirnov-Orlicz space EM,ω (G0), we prove that interpolating polynomials and Poisson polynomials are near best approximant for f. Also considering a weighted fractional moduli of smoothness, we obtain direct and converse theorems of trigonometric polynomial approximation in Orlicz spaces with Muckenhoupt weights. On the bases of these approximation theorems, we prove direct and converse theorems of approximatio...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research
Body mass index and the risk of obesity in coeliac disease treated with the gluten‐free dietEmail this article to a colleague.
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ConclusionsIndividuals with coeliac disease have lower BMI than the regional population at diagnosis. BMI increases on the GFD, especially in those that adhere closely to the GFD. On the GFD, 15.8% of patients move from a normal or low BMI class into an overweight BMI class, and 22% of patients overweight at diagnosis gain weight. These results indicate that weight maintenance counselling should be an integral part of coeliac dietary education. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 8, 2012 Category: Drugs & Pharmacology Authors: T. A. KabbaniA. GoldbergC. P. KellyK. PallavS. TariqA. PeerJ. HansenM. DennisD. A. Leffler Tags: Original Article Source Type: research
Merck provides suvorexant insomnia updateEmail this article to a colleague.
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Merck plans to file a new drug application with the US Food and Drug Administration in 2012 (Source: Pharmacy Europe)
Source: Pharmacy Europe - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Computer order entry systems reduce drug eventsEmail this article to a colleague.
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Research suggests CPOEs are effective at reducing drug-related injury and harm (Source: Pharmacy Europe)
Source: Pharmacy Europe - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Bexsero® shows promise for meningococcal BEmail this article to a colleague.
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Pivotal study confirms potential of vaccine to protect infants against meningococcal serogroup B (Source: Pharmacy Europe)
Source: Pharmacy Europe - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
NPC publishes sixth issue of 'tough decisionsEmail this article to a colleague.
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Source: NPC
Area: News
The National Prescribing Centre (NPC) has published the sixth edition of its newsletter 'Tough Decisions', a quarterly publication available to all NHS personnel making decisions about the funding and commissioning of medicines at a local level. This issue addresses the following topics:
. Local decision-making news.in brief
. How the NPC and NICE can help you and your commissioning groups
. New medicines - are you prepared?
. Managing medicines across a health community - is your Area Prescribing Committee fit for purpose?
. IFR manager newsSharing practi...
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Editorial - Cardiovascular risk in androgen suppressionEmail this article to a colleague.
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Source: Heart
Area: News
This editorial discusses the issue of cardiovascular risk in androgen suppression since evidence from observational data suggests that androgen suppression therapy may significantly increase cardiovascular morbidity and mortality. (Source: NeLM - News)
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
EU proposals for a new public procurement directiveEmail this article to a colleague.
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Source: NHS Confederation
Area: News
The European Commission has published legal proposals to revise the existing EU public procurement rules. This briefing outlines the key changes proposed to the legal framework and seeks views from NHS organisations on the likely implications for the NHS. (Source: NeLM - News)
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Four new guides to improve mental health commissioningEmail this article to a colleague.
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Source: NHS Networks
Area: News
The Joint Commissioning Panel for Mental Health has developed four practical guides to help current and future commissioners plan and deliver high quality mental health services have been published.
The guides focus on primary mental health care services, child and adolescent mental health service transitions, dementia services and acute liaison services bringing together scientific evidence, patient and carer experience and viewpoints, and examples of best practice. (Source: NeLM - News)
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Review: Diagnosis and management of Raynaud's phenomenonEmail this article to a colleague.
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Source: BMJ
Area: News
This review featured by the BMJ discusses the diagnosis and management of Raynauds phenomenon under the following sub-headings:
. Who gets Raynaud's phenomenon?
. What are the symptoms?
. What causes Raynaud's phenomenon?
. How are patients with Raynaud's phenomenon assessed?
. When and who to refer?
. How is Raynaud's phenomenon treated?
. Does surgery have a role in treatment? (Source: NeLM - News)
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Horizon scanning: AmiKetT for peripheral neuropathic pain filed for FDA fast track designationEmail this article to a colleague.
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Source: BioSpace
Area: News
According to a Biospace report, EpiCept has filed AmiKetT (amitriptyline 4%, ketamine 2% cream) for Fast Track designation with the U.S. Food and Drug Administration (FDA).
AmiKetT is a prescription topical cream under late stage clinical development by EpiCept for the treatment of chemotherapy-induced peripheral neuropathic pain. (Source: NeLM - News)
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Horizon scanning: FDA Grants priority review of pertuzumab for untreated HER2-Positive metastatic breast cancerEmail this article to a colleague.
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Source: BioSpace
Area: News
According to a Biospace report, the U.S. Food and Drug Administration (FDA) has granted Priority Review for pertuzumab in combination with trastuzumab and docetaxel chemotherapy for people with HER2-positive metastatic or locally recurrent, unresectable breast cancer, who have not received previous treatment or whose disease has relapsed after adjuvant therapy. (Source: NeLM - News)
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Horizon scanning: FDA Grants priority review of crofelemer for diarrhoea in patients with HIV/AIDS on anti-retroviral therapyEmail this article to a colleague.
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Source: BioSpace
Area: News
According to a Biospace report, the U.S. Food and Drug Administration (FDA) has granted Priority Review for crofelemer 125 mg tablets for the control and symptomatic relief of diarrhoea in patients with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) on anti-retroviral therapy. (Source: NeLM - News)
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Horizon scanning: FDA approves SkliceT (ivermectin) Lotion for the treatment of head liceEmail this article to a colleague.
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Source: PharmaLive
Area: News
According to a Pharmalive report, the U.S. Food and Drug Administration (FDA) has approved Sklice® (ivermectin) lotion, 0.5% for the topical treatment of head lice, in patients 6 months of age and older. The treatment involves a single 10-minute application without nit combing.
The approval was based on results of two randomized, double-blind phase III clinical trials that compared Sklice Lotion with a vehicle control (placebo) in 781 patients from the United States who were 6 months of age and older. More subjects in the treatment group were louse-free without any nit combi...
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Horizon scanning: FDA approves VyvanseT (lisdexamfetamine dimesylate) for maintenance of ADHD in adultsEmail this article to a colleague.
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Source: BioSpace
Area: News
The US Food and Drug Administration (FDA) has approved Vyvanse® (lisdexamfetamine dimesylate) capsules for the maintenance treatment of adults with Attention-Deficit/Hyperactivity Disorder (ADHD). This new approval is additional to the indication for Vyvanse as a treatment for ADHD in patients aged 6 years and above.
The approval is based on results from a six-week phase IV, double-blind, multi-centre, placebo-controlled, randomized withdrawal design study which assessed the maintenance of efficacy and safety of Vyvanse in 123 adults who met DSM-IV-TR® criteria for ADHD.
&...
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Cost-effectiveness of bivalirudin versus heparin plus glycoprotein IIb/IIIa inhibitor for acute MI in the UKEmail this article to a colleague.
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Source: Heart
Area: News
This model-based cost-utility analysis assessed the cost-effectiveness of bivalirudin versus heparin and glycoprotein IIb/IIIa inhibitor (H-GPI) in patients undergoing primary percutaneous coronary intervention (PPCI) for acute ST-segment elevation myocardial infarction (STEMI), and was provided for the NICE appraisal of bivalirudin use in STEMI patients undergoing PPCI.
The model evaluated incremental costs, and incremental clinical effectiveness expressed as quality-adjusted life-years (QALYs) gained.
The following findings were reported:
. The main model (clinical e...
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
CADTH rapid response report: Botulinum toxin A for migraine headachesEmail this article to a colleague.
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Source: Canadian Agency for Drugs and Technologies in Health (CADTH)
Area: News
This rapid response report from the Canadian Agency for Drugs and Technologies in Health (CADTH) reviews the clinical effectiveness of botulinum toxin A for reduction in pain and improvement of functioning in patients with migraine headache
It found that, 'the evidence is inconclusive regarding the clinical effectiveness of botulinum toxin A for reduction in pain and improvement of functioning in patients with migraine headache'.
The Rapid Response Service is an information service for those involved in planning and provi...
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
CADTH rapid response report: Antivirals for pandemic and human avian influenzasEmail this article to a colleague.
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Source: Canadian Agency for Drugs and Technologies in Health (CADTH)
Area: News
This rapid response report from the Canadian Agency for Drugs and Technologies in Health (CADTH) reviews the evidence on the clinical benefits and harms of antivirals for the treatment and prevention of pandemic influenza A (H1N1) and human avian influenza A (H5N1).
It found that, 'There is limited evidence that oseltamivir is clinically effective for the treatment of pandemic influenza A (H1N1) and limited evidence that it is especially effective with treatment within 48 hours of symptom onset. There is insufficient evidence to mak...
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
DTB comment: Quarterly vs monthly INR monitoring of warfarin patientsEmail this article to a colleague.
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Source: DTB
Area: News
This Comment in the Drug and Therapeutics Bulletin (DTB) discusses the results of a non-inferiority study that demonstrated INR monitoring every 12 weeks was as safe as INR monitoring every 4 weeks (see NELM abstract for further details).
The DTB notes that "a 12-week INR testing frequency is probably safe for patients whose INR is stable if they continue to have clinician support. But this is a small single-centre study and the researchers caution that further research is needed before INR testing every 12 weeks can be routinely recommended. They also noted several limitations to their ...
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
RCT: Fidaxomicin versus vancomycin for Clostridium difficile infectionEmail this article to a colleague.
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Source: Lancet Infectious Diseases
Area: News
This double-blind, randomised controlled, non-inferiority trial compared the efficacy and safety of oral fidaxomicin and oral vancomycin for the treatment of patients with Clostridium difficile (C difficile) infection in 45 sites across Europe, Canada, and the USA.
Eligible patients, aged 16 years or older with acute, toxin-positive C difficile infection were randomised to fidaxomicin (n=270; 200 mg every 12 h) or vancomycin (n=265; 125 mg every 6 h) for 10 days. Non-inferiority was prespecified with a margin of 10%. Modified intention-to-treat (mITT) and per-...
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Eyes on evidence: Treating staggered paracetamol overdoseEmail this article to a colleague.
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Source: NHS Evidence
Area: News
The February edition of 'Eyes on Evidence', the free monthly e-bulletin from NHS Evidence covering major new evidence with an explanation about what it means for current practice, includes an expert commentary on new evidence from a large single centre cohort study which examined the clinical impact of staggered overdoses and delayed presentation following paracetamol overdose.
The study analysed data from 663 patients who were admitted for paracetamol-induced liver injury, of whom 161 (24.3%) had taken a staggered overdose, usually to relieve a variety of common pains, such as a...
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Eyes on evidence: Biologic drugs for the treatment of psoriasisEmail this article to a colleague.
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Source: NHS Evidence
Area: News
The February edition of 'Eyes on Evidence', the free monthly e-bulletin from NHS Evidence covering major new evidence with an explanation about what it means for current practice, includes an expert commentary on new evidence from a meta-analysis which produced a quantitative comparison of all currently licensed biologics, providing estimates on comparative effectiveness and a suggested ranking of treatments.
Twenty trials involving patients with a mean disease duration of 18-22 years were included in the meta-analysis. The analysis suggests a ranking of treatments in terms of ef...
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
NHS Evidence Update: Reducing the risk of VTEEmail this article to a colleague.
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Source: NHS Evidence
Area: News
This latest update identifies new evidence relevant AND SUBSEQUENT TO to NICE clinical guideline 92 'Reducing the risk of venous thromboembolism (VTE) in patients admitted to hospital' (published 2010) that might generate future change to the practice laid out in the guidance.
Key messages pertaining to newly published evidence include the following:
. Evidence appears to confirm that thalidomide in patients with multiple myeloma (MM) may increase the risk of venous thromboembolism (VTE), and evidence now also suggests an elevated risk with lenalidomide in this po...
Source: NeLM - News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Methylprednisolone 1000 mg powder and solvent for solution for injection/infusion- New ProductEmail this article to a colleague.
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Source: eMC (electronic Medicines Compendium)
Area: Other Library Updates > SPC Changes
Beacon Pharmaceuticals has launched Methylprednisolone 1000 mg powder and solvent for solution for injection/infusion.
Please refer to the link below for the New SPC for new product. (Source: NeLM - SPC Changes)
Source: NeLM - SPC Changes - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Potactasol 4mg powder for concentrate for solution for infusion (topotecan)- New ProductEmail this article to a colleague.
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Source: eMC (electronic Medicines Compendium)
Area: Other Library Updates > SPC Changes
Actavis has launched Potactasol 4mg powder for concentrate for solution for infusion (topotecan). Topotecan monotherapy is indicated for the treatment of patients with metastatic carcinoma of the ovary after failure of first-line or subsequent therapy and patients with relapsed small cell lung cancer (SCLC) for whom re-treatment with the first-line regimen is not considered appropriate.
It can be used in combination with cisplatin for patients with carcinoma of the cervix recurrent after radiotherapy and for patie...
Source: NeLM - SPC Changes - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Clonazepam Oral Solution- New ProductEmail this article to a colleague.
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Source: eMC (electronic Medicines Compendium)
Area: Other Library Updates > SPC Changes
Rosemont Pharmaceuticals Ltd has launched Clonazepam 0.5mg/5ml and 2mg/5ml oral solutions. It is indicated for all clinical forms of epileptic disease and seizures (petit mal) including atypical absence; primary or secondarily generalised tonic-clonic (grand mal), tonic or clonic seizures; partial (focal) seizures with elementary or complex symptomatology; various forms of myoclonic seizures, myoclonus and associated abnormal movements.
Please refer to the links below for the New SPC for new product Clonazepam oral...
Source: NeLM - SPC Changes - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Diovan 3mg/ml Oral Solution - New ProductEmail this article to a colleague.
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Source: eMC (electronic Medicines Compendium)
Area: Other Library Updates > SPC Changes
Novartis has launched Diovan 3mg/ml Oral Solution for the treatment of hypertension in children and adolescents 6 to 18 years of age.
Please refer to the link below for the New SPC for new product Diovan oral solution. (Source: NeLM - SPC Changes)
Source: NeLM - SPC Changes - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
GLIVEC Tablets (imatinib)- Revised SPCEmail this article to a colleague.
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Source: eMC (electronic Medicines Compendium)
Area: Other Library Updates > SPC Changes
There have been significant updates to several sections of the SPC, including the following:
Change to section 4.2 - Posology and method of administration
Patients with renal dysfunction or on dialysis should be given the minimum recommended dose of 400 mg daily as starting dose. However, in these patients caution is recommended. The dose can be reduced if not tolerated. If tolerated, the dose can be increased for lack of efficacy (see sections 4.4 and 5.2).
Change to sec...
Source: NeLM - SPC Changes - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
Do gastric adverse events influence the choice of bisphosphonate for the treatment of osteoporosis?Email this article to a colleague.
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Source: Regional Drug and Therapeutics Centre
Area: Evidence > Medicines Q & A
The bisphosphonates are a group of drugs used to reduce bone turnover in conditions including osteoporosis, Paget's disease, and bone malignancies. The therapeutic effect is achieved by inhibiting bone resorption.
As a group the bisphosphonates are generally well tolerated, but have a well documented adverse effect (AE) profile, and gastrointestinal effects are a known issue. Strict administration requirements have been introduced to reduce the risk of oesophageal AEs, and inability to meet these requirements is considered...
Source: NeLM - Medicines Q and A - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
London Cancer New Drugs Group Rapid Review:Erlotinib for the first-line treatment of advanced NSCLC with EGFR mutationEmail this article to a colleague.
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Source: London Cancer New Drugs Group
Area: Evidence > Drug Specific Reviews
Current NICE-approved first-line treatments for patients with NSCLC who have EGFR activating mutations include platinum-doublet chemotherapy (mainly gemcitabine plus cisplatin or carboplatin in the UK), gefitinib, and pemetrexed plus cisplatin (for adenocarcinoma or large-cell carcinoma only).
Erlotinib has recently had its license extended to include the first-line treatment of patients with locally advanced or metastatic NSCLC with EGFR activating mutations. In the European registration Phase III study (EURTAC), erlot...
Source: NeLM - Drug Specific Reviews - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
FDA grants priority review to GI agent for controlling diarrhea in HIV/AIDS patientsEmail this article to a colleague.
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FDA has granted priority review to crofelemer 125-mg tablets (Salix Pharmaceuticals) for the control
and symptomatic relief of diarrhea in patients with HIV/AIDS on anti-retroviral therapy (ART). (Source: Drug Topics - Clinical News)
Source: Drug Topics - Clinical News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
FDA grants priority review to GI agent for controlling diarrhea in HIV/AIDS patientsEmail this article to a colleague.
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Discuss or comment on this article.
FDA has granted priority review to crofelemer 125-mg tablets (Salix Pharmaceuticals) for the control
and symptomatic relief of diarrhea in patients with HIV/AIDS on anti-retroviral therapy (ART). (Source: Drug Topics - Top News)
Source: Drug Topics - Top News - February 8, 2012 Category: Drugs & Pharmacology Source Type: news
