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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Acidic sialidase activity is aberrant in obese and diabetic mice.
We examined fluctuations in mRNA levels and sialidase activities of NEU1 in two strains of obese and diabetic mice to assess the involvement of NEU1 in obesity. The activity of NEU1 was preferentially higher in epididymal fat and lower in the livers of two strains of obese and diabetic mice. Fluctuations in NEU1 activity might be associated with the pathological status of these tissues in obesity. PMID: 23727924 [PubMed - in process] (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - June 8, 2013 Category: Drugs & Pharmacology Authors: Natori Y, Ohkura N, Nasui M, Atsumi G, Kihara-Negishi F Tags: Biol Pharm Bull Source Type: research

Antitumor Activity and DNA-Binding Investigations of Isoeuxanthone and Its Piperidinyl Derivative.
Abstract The binding mode and affinity of isoeuxanthone (1,6-dihydroxyxanthone) (1) and its piperidinyl derivative (1-hydroxy-6-(2-(1-piperidinyl)ethoxy)xanthone) (2) with calf thymus DNA were studied using absorption spectroscopy, fluorescence spectroscopy, circular dichroism (CD) spectroscopy and viscosity measurements. Results indicate that the two xanthones can intercalate into the DNA base pairs by the plane of xanthone ring and the binding affinity of the piperidinylethoxy substituted xanthone 2 is stronger than 1. In addition, the cytotoxic effects of both compounds were evaluated with the human cervical can...
Source: Chemical and Pharmaceutical Bulletin - June 7, 2013 Category: Drugs & Pharmacology Authors: Wang H, Wei L, Yan H, Gao X, Xu B, Tang N Tags: Chem Pharm Bull (Tokyo) Source Type: research

Chemical variability in the essential oils from leaves of Syzygium jambos
Syzygium jambos (L.) Alston, Myrtaceae, occurs in tropical regions and is a widespread medicinal plant used to treat several diseases, such as hemorrhage, dysentery, diabetes, inflammation, diabetes and gastrointestinal disorders. Leaf essential oils of ten specimens of S. jambos collected from two localities of Central Brazilian Cerrado were investigated by GC-MS. Soil and foliar nutrients were analyzed to determine the mineral compositions. The aims of this study was to evaluate the influence of environmental factors on chemical composition of leaf essential oils of S. jambos. Studies on the influence of environmental fa...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Comparative effects of mature coconut water (Cocos nucifera) and glibenclamide on some biochemical parameters in alloxan induced diabetic rats
In the present study, comparative effects of mature coconut water (Cocos nucifera L., Arecaceae) and glibenclamide in alloxan induced diabetic rats were evaluated. Diabetes mellitus was induced in Sprague-Dawly rats using alloxan monohydrate (150 mg kg-1 body weight). Treatment with lyophilized form of mature coconut water and glibenclamide in diabetic rats reduced the blood glucose and glycated hemoglobin along with improvement in plasma insulin level. Elevated levels of liver function enzymes markers like alkaline phosphatase, serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase in diabetic...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Topical anti-inflammatory activity of yacon leaf extracts
In conclusion, yacon leaf extracts, particularly the sesquiterpene lactone-rich extract, has potential use as topical anti-inflammatory agent. (Source: Revista Brasileira de Farmacognosia)
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Perceptions and activities of religious leaders on the prevention of HIV/AIDS and care of people living with the HIV infection in Ibadan, Nigeria
Asekun-Olarinmoye IO, Asekun-Olarinmoye EO, Fatiregun A, Fawole OI (Source: Therapeutics and Clinical Risk Management)
Source: Therapeutics and Clinical Risk Management - June 11, 2013 Category: Drugs & Pharmacology Source Type: research

Triterpenes with Cytotoxicity from the Leaves of Vernicia fordii.
Abstract Two new triterpenes, (1α,3β,8α,9β,10α,13α,14β)-9,10-dimethyl-25,26-dinorolean-5-en-1,3-diol (1) and (1α,3β,6β)-olean-12-en-1,3,6-triol (2) were isolated from the leaves of Aleurites fordii, together with five known triterpenes. The structures of isolates were established by one dimensional (1D)- and 2D-NMR spectroscopic data along with MS analysis. Of the isolated compounds, 1, 2 and 4 (daturadiol) displayed moderate cytotoxicities against two or more human cancer cell lines in HepG2 (hepatocellular carcinoma), SK-OV-3 (ovarian carcinoma), A-549 (lung carcinoma) and SNU-1 (gastric carcinoma). ...
Source: Chemical and Pharmaceutical Bulletin - June 7, 2013 Category: Drugs & Pharmacology Authors: Pei YH, Kwon OK, Lee JS, Cha HJ, Ahn KS, Oh SR, Lee HK, Chin YW Tags: Chem Pharm Bull (Tokyo) Source Type: research

Effects of intrathecal dexmedetomidine on low-dose bupivacaine spinal anesthesia in elderly patients undergoing transurethral prostatectomy.
Abstract Low-dose bupivacaine can limit the spinal block level with minimal hemodynamic effects and yield a rapid recovery, but sometimes it may not provide adequate anesthesia for surgery. Dexmedetomidine, a selective α2-adrenoreceptor agonist, was shown to be a potent antinociceptive agent when given intrathecally in animals and humans. The purpose of this study was to evaluate the adjuvant effects of intrathecal dexmedetomidine in elderly patients undergoing transurethral prostate surgery with low-dose bupivacaine spinal anesthesia. Fifty-four patients undergoing transurethral prostate surgery were randomized i...
Source: Biological and Pharmaceutical Bulletin - June 8, 2013 Category: Drugs & Pharmacology Authors: Kim JE, Kim NY, Lee HS, Kil HK Tags: Biol Pharm Bull Source Type: research

Education and Practice for Pharmacists Being a Connection between Physicians and Persons Having Unawareness of Mental Illness.
This article will argue about the methodology and education for pharmacists to connect undiagnosed patients to the appropriate medical care. It is proposed that the pharmacists should encourage the undiagnosed psychiatric patients to contact with the primary care physician. In addition, pharmacists should recommend the change of prescription to the medical doctors who examine the patients expected the addiction to the prescribed drug. PMID: 23728091 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 8, 2013 Category: Drugs & Pharmacology Authors: Kawamura K Tags: Yakugaku Zasshi Source Type: research

DUAL ACTION CHERRY COUGH SUPPRESSANT ORAL ANESTHETIC (Menthol) Lozenge [Ricola Ag]
Updated Date: Jun 3, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - June 3, 2013 Category: Drugs & Pharmacology Source Type: news

Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats.
Conclusions: Our results showed that nisoxetine displayed a more potent and prolonged spinal anesthesia with a more sensory/nociceptive-selective action over motor blockade, compared with mepivacaine. The local anesthetic effect of nisoxetine could be probably due to the suppression of Na(+) currents. PMID: 23744419 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 12, 2013 Category: Drugs & Pharmacology Authors: Leung YM, Chu CC, Kuo CS, Chen YW, Wang JJ Tags: Pharmacol Rep Source Type: research

Concentrations of Diazepam and Nordiazepam in 1000 Blood Samples From Apprehended Drivers--Therapeutic Use or Abuse of Anxiolytics?
Using an in-house forensic toxicology database, we selected 1000 cases of driving under the influence of drugs (DUIDs) over a 12-month period if diazepam (D) and nordiazepam (ND) were both present in the blood samples. Quantitative analysis of D and ND in blood was done by solvent extraction (butyl acetate) and capillary column gas chromatography (GC) with a nitrogen–phosphorous (N-P) detector. The limits of quantitation of this analytical method for D and ND in blood were 0.05 mg/L. The correlation between D and ND concentrations in blood was statistically significant (r = .58, P < .001), as expected for a parent...
Source: Journal of Pharmacy Practice - June 5, 2013 Category: Drugs & Pharmacology Authors: Jones, A. W., Holmgren, A. Tags: Research Articles Source Type: research

Drug Abuse Treatment Rates on the Rise: U.S. Report
A 15% drop for alcohol abuse while cases of marijuana, prescription painkiller abuse rise (Source: Pharmacy News - Doctors Lounge)
Source: Pharmacy News - Doctors Lounge - December 28, 2010 Category: Drugs & Pharmacology Authors: webmaster at doctorslounge.com Tags: Nursing, Pharmacy, Dependence, Preventive Medicine, News, Source Type: news

DHA supplement not associated with slower cognitive, functional decline in mild to moderate Alzheimer's disease
DHA supplementation doesn?t appear to slow the rate of cognitive and functional decline in individuals with mild to moderate Alzheimer?s disease, according to research published in the November 3 issue of the Journal of the American Medical Association, HealthDay News reported. (Source: Drug Topics - Clinical News)
Source: Drug Topics - Clinical News - December 29, 2010 Category: Drugs & Pharmacology Source Type: news

Arthritis drug disappointment
Recent news of fostamatinib’s latest failure to meet clinical endpoints marks yet another blow to an already weakened rheumatoid arthritis (RA) therapeutics pipeline, and may drive manufacturers to investigate fresh approaches to drug development, says an analyst with research and consulting firm GlobalData. (Source: Pharmacy Europe)
Source: Pharmacy Europe - June 7, 2013 Category: Drugs & Pharmacology Source Type: news

The pharmacist as gatekeeper: combating medication abuse and dependence.
This article begins by reviewing the fundamental terms involved in understanding the nonmedical use of medications, including abuse, dependence, and intoxication. The current situation of substance abuse and dependence is then introduced through a summary of several epidemiological surveys conducted in Japan. Finally, the role of pharmacists as gatekeepers in preventing substance abuse and dependence on medications is discussed. PMID: 23728090 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 8, 2013 Category: Drugs & Pharmacology Authors: Shimane T Tags: Yakugaku Zasshi Source Type: research

Down-regulation of thymic stromal lymphopoietin by curcumin.
Conclusion: These results suggest that curcumin can be used to treat inflammatory and atopic diseases through the suppression of TSLP. PMID: 23744438 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 12, 2013 Category: Drugs & Pharmacology Authors: Moon PD, Jeong HJ, Kim HM Tags: Pharmacol Rep Source Type: research

Neural plasticity and the Kennard Principle - does it work for the preterm brain?
This article is protected by copyright. All rights reserved. PMID: 23735123 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - June 5, 2013 Category: Drugs & Pharmacology Authors: Bennet L, Van Den Heuij L, Dean JM, Drury P, Wassink G, Gunn AJ Tags: Clin Exp Pharmacol Physiol Source Type: research

The effect of obesity on antibiotic treatment failure: a historical cohort study
ConclusionObesity is a significant risk factor for ATF, and this association may be due to the current “one size fits all” dosing strategy, which warrants further investigation. Copyright © 2013 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - June 4, 2013 Category: Drugs & Pharmacology Authors: Cristina Longo, Gillian Bartlett, Brenda MacGibbon, Nancy Mayo, Ellen Rosenberg, Lyne Nadeau, Stella S. Daskalopoulou Tags: Original Report Source Type: research

Sustained-release progesterone vaginal suppositories 3-development and clinical feasibility testing-.
In conclusion, the sustained-release vaginal suppository prepared in this study was considered to be useful for clinical treatment. PMID: 23728096 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 8, 2013 Category: Drugs & Pharmacology Authors: Nakayama A, Yamaguchi N, Ohno Y, Miyata C, Kondo H, Sunada H, Okamoto H Tags: Yakugaku Zasshi Source Type: research