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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Intrathecal Ketamine and Pregabalin at Sub-effective Doses Synergistically Reduces Neuropathic Pain without Motor Dysfunction in Mice.
Abstract Peripheral or central nerve injury often leads to neuropathic pain. Although ketamine and pregabalin are first line options for the treatment of neuropathic pain, their clinical application is limited due to side effects such as sedation, dizziness and somnolence. We designed this study to determine whether the intrathecal (i.t.) co-treatment with ketamine and pregabalin at sub-effective low doses would elicit a sufficient pain relief without producing side effect in a neuropathic pain mouse model. At day 7 after chronic constriction injury (CCI) of sciatic nerve, dose dependent effects of i.t. ketamine (3...
Source: Biological and Pharmaceutical Bulletin - February 1, 2013 Category: Drugs & Pharmacology Authors: Lim HS, Kim JM, Choi JG, Ko YK, Shin YS, Jeon BH, Park JB, Lee JH, Kim HW Tags: Biol Pharm Bull Source Type: research

Association between novel MRI‐estimated pancreatic fat and liver histology‐determined steatosis and fibrosis in non‐alcoholic fatty liver disease
ConclusionsIn patients with NAFLD, increased pancreatic fat is associated with hepatic steatosis. However, liver fibrosis is inversely associated with pancreatic fat content. Further studies are needed to determine underlying mechanisms to understand if pancreatic steatosis affects progression of NAFLD. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 6, 2013 Category: Drugs & Pharmacology Authors: N. S. Patel, M. R. Peterson, D. A. Brenner, E. Heba, C. Sirlin, R. Loomba Tags: Original Article Source Type: research

Discovering some novel 7-chloroquinolines carrying a biologically active benzenesulfonamide moiety as a new class of anticancer agents.
Abstract Based on the reported anticancer activity of quinolines, a new series of 7-chloroquinoline derivatives bearing the biologically active benzenesulfonamide moiety 2-17 and 19-25 were synthesized starting with 4,7-dichloroquinolne 1. Compound 17 was the most active compound with IC(50) value 64.41, 75.05 and 30.71 µM compared with Doxorubicin as reference drug with IC(50) values 82.53, 88.32 and 73.72 µM on breast cancer cells, skin cancer cells and neuroblastoma, respectively. All the synthesized compounds were evaluated for their in vitro anticancer activity on breast cancer cells, skin cancer cells a...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2013 Category: Drugs & Pharmacology Authors: Al-Dosari MS, Ghorab MM, Al-Said MS, Nissan YM Tags: Chem Pharm Bull (Tokyo) Source Type: research

FDA Approves Ravicti for the Chronic Management of Some Urea Cycle Disorders
February 1, 2013 -- The U.S. Food and Drug Administration today approved Ravicti (glycerol phenylbutyrate) for the chronic management of some urea cycle disorders (UCDs) in patients ages 2 years and older. UCDs are genetic disorders that involve... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - February 1, 2013 Category: Drugs & Pharmacology Source Type: news

Liraglutide overdose: Gastrointestinal symptoms: case report
(Source: Reactions)
Source: Reactions - February 6, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Ginsenoside rh1 ameliorates high fat diet-induced obesity in mice by inhibiting adipocyte differentiation.
Abstract Ginseng (the root of Panax ginseng C. A. MEYER), which contains protopanaxadiols and protopanaxatriols as its main constituents, has been used for many disorders, such as cancer, diabetes, inflammation, and hyperlipidemia. Of these ginsenosides, protopanaxadiol ginsenoside Rh2 alone is reported to inhibit adipogenesis in 3T3-L1 in vitro. Therefore, we investigated the effect of protopanaxatriol ginsenoside Rh1 on adipogenesis in 3T3-L1 cells and high fat diet-induced obesity (DIO) mice. Treatment with ginsenoside Rh1 inhibited adipogenesis, as evidenced by Oil red O staining and lipid droplet extraction as...
Source: Biological and Pharmaceutical Bulletin - February 1, 2013 Category: Drugs & Pharmacology Authors: Gu W, Kim KA, Kim DH Tags: Biol Pharm Bull Source Type: research

The Pharmacology of L-DOPA-Induced Dyskinesia in Parkinson's Disease.
Abstract l-3,4-Dihydroxyphenylalanine (l-DOPA) remains the most effective symptomatic treatment of Parkinson's disease (PD). However, long-term administration of l-DOPA is marred by the emergence of abnormal involuntary movements, i.e., l-DOPA-induced dyskinesia (LID). Years of intensive research have yielded significant progress in the quest to elucidate the mechanisms leading to the development and expression of dyskinesia and maintenance of the dyskinetic state, but the search for a complete understanding is still ongoing. Herein, we summarize the current knowledge of the pharmacology of LID in PD. Specifically,...
Source: Pharmacological Reviews - February 1, 2013 Category: Drugs & Pharmacology Authors: Huot P, Johnston TH, Koprich JB, Fox SH, Brotchie JM Tags: Pharmacol Rev Source Type: research

Aciclovir: Neurological disorders: case report
(Source: Reactions)
Source: Reactions - February 6, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Risk of liver injury with Tolvaptan
(Source: Reactions)
Source: Reactions - February 6, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Warner Chilcott Announces FDA Approval of New Ulcerative Colitis Product Delzicol
DUBLIN, Ireland, Feb. 5, 2013 -- Warner Chilcott plc today announced that the United States Food and Drug Administration (FDA) has approved its new 400 mg mesalamine product indicated for the treatment of ulcerative colitis. The product will be... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - February 6, 2013 Category: Drugs & Pharmacology Source Type: news

Absorption, Storage and Distribution of β-Cryptoxanthin in Rat after Chronic Administration of Satsuma Mandarin (Citrus unshiu MARC.) Juice.
In this study, we measured serum and the content of β-cryptoxanthin in several rat tissues after chronic ingestion of Satsuma mandarin extract rich in β-cryptoxanthin. Rats were fed a standard commercial diet containing Satsuma mandarin extract (containing β-cryptoxanthin at 11.7 mg/kg diet) for eight weeks. After 3 h of fasting, serum, liver, spleen, kidney, lung, heart, testis, brain, and epididymal fat were collected. The concentrations of β-cryptoxanthin in serum and tissues were evaluated by high-performance liquid chromatography. There was a wide range in the tissue levels of β-cryptoxanthin; liver had the g...
Source: Biological and Pharmaceutical Bulletin - February 1, 2013 Category: Drugs & Pharmacology Authors: Sugiura M, Ogawa K, Yano M Tags: Biol Pharm Bull Source Type: research

Canadian statin labels have been updated to warn of a risk of increased blood sugar levels and a small increased risk of diabetes among at-risk patients.
(Source: Reactions)
Source: Reactions - February 6, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Neurodegenerative disease: Targeting pre-existing plaques in AD
Nature Reviews Drug Discovery 12, 100 (2013). doi:10.1038/nrd3939 Author: Man Tsuey Tse Extracellular plaques of amlyoid-β (Aβ) in the brain are one of the hallmarks of Alzheimer's disease (AD). As these plaques are thought to trigger a cascade of events that ultimately lead to the neurodegenerative symptoms of the disease, many therapeutics have been developed with the (Source: Nature Reviews Drug Discovery)
Source: Nature Reviews Drug Discovery - February 1, 2013 Category: Drugs & Pharmacology Authors: Man Tsuey Tse Tags: Research Highlight Source Type: research

Antibacterial drugs: New antibiotics on the horizon?
Nature Reviews Drug Discovery 12, 99 (2013). doi:10.1038/nrd3940 Author: Sarah Crunkhorn Staphylococcus aureus is responsible for a variety of diseases ranging from skin and soft-tissue infections to pneumonia and sepsis. The increasing prevalence of multidrug-resistant bacterial strains and the lack of new classes of antibiotics have together made the effective treatment of such infections challenging. (Source: Nature Reviews Drug Discovery)
Source: Nature Reviews Drug Discovery - February 1, 2013 Category: Drugs & Pharmacology Authors: Sarah Crunkhorn Tags: Research Highlight Source Type: research

Collagen Stimulating Effect of Peptide Amphiphile C16–KTTKS on Human Fibroblasts
Molecular PharmaceuticsDOI: 10.1021/mp300549d (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - February 4, 2013 Category: Drugs & Pharmacology Authors: Roanne R. Jones, Valeria Castelletto, Che J. Connon and Ian W. Hamley Source Type: research

Foreword.
PMID: 23302629 [PubMed - in process] (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - February 1, 2013 Category: Drugs & Pharmacology Authors: Tanonaka K Tags: Biol Pharm Bull Source Type: research

Durable response of cutaneous squamous cell carcinoma following high-dose peri-lesional injections of Viscum album extracts – A case report
Conclusion: The presented case shows clinical response of a CSCC to high-dose peri-lesional VAE injections. Further research on VAE in CSCC is warranted. (Source: Phytomedicine)
Source: Phytomedicine - February 11, 2013 Category: Drugs & Pharmacology Authors: Paul Georg Werthmann, Gregor Sträter, Hedda Friesland, Gunver Sophia Kienle Tags: Oncology and Hematology Source Type: research

Triglyceride-induced macrophage cell death is triggered by caspase-1.
Abstract Triglyceride (TG) induces macrophage cell death which contributes to the development of atherosclerosis. We confirmed that exogenous TG accumulates in human THP-1 macrophages and causes cell death. TG treated THP-1 macrophages exhibited no change in tumor necrosis factor (TNF)-α, interleukin (IL)-18, macrophage inflammatory protein (MIP)-1α, and IL-1R1 receptor mRNA expression. However, there was a marked decrease in IL-1β mRNA expression but an increase in IL-1β protein secretion. Decreased expression of IL-1β mRNA and increased secretion of IL-1β protein was not the direct cause of cell death. Unti...
Source: Biological and Pharmaceutical Bulletin - February 1, 2013 Category: Drugs & Pharmacology Authors: Son SJ, Rhee KJ, Lim J, Kim TU, Kim TJ, Kim YS Tags: Biol Pharm Bull Source Type: research

Comparison of the Permeability of Metoprolol and Labetalol in Rat, Mouse, and Caco-2 Cells: Use as a Reference Standard for BCS Classification
Molecular PharmaceuticsDOI: 10.1021/mp300410n (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - February 4, 2013 Category: Drugs & Pharmacology Authors: Tuba Incecayir, Yasuhiro Tsume and Gordon L. Amidon Source Type: research

Role of Electrostatic Potential in the in Silico Prediction of Molecular Bioactivation and Mutagenesis
Molecular PharmaceuticsDOI: 10.1021/mp3004385 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - February 1, 2013 Category: Drugs & Pharmacology Authors: Kevin A. Ford Source Type: research