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This page shows you the most recent publications within this specialty of the MedWorm directory.

10 Foolproof Ways To Permanently Free Up More Time
Success is awesome but it comes with one unfortunate by-product: the more successful you are the busier you tend to be. Pretty soon you fall prey to the tyranny of "more": more meetings, more projects, more decisions and more items on your to-do list. Eventually something has to give and that something is usually you -- unless you do something about it. Here are some simple ways to regain more of the most valuable thing you have, time: 1. Remove one point of acquiescence. It might be hard to think of think this way, but how you behave shows people how they can treat you. For example, if you let employees interrupt you...
Source: Healthy Living - The Huffington Post - December 19, 2014 Category: Consumer Health Advice Source Type: news

Pharmacist input into statewide treatment protocols for emergency medical services.
CONCLUSION: An EM pharmacist participated in the review and development of statewide EMS treatment protocols that focused on choice of medication therapy, dosage, administration, and identification and minimization of potential risks of medication errors. PMID: 25511840 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - December 19, 2014 Category: Drugs & Pharmacology Authors: Groth ME, McMillian WD, Wolfson DL Tags: Am J Health Syst Pharm Source Type: research

Editorial Comment
The authors in this study used the National Electronic Injury Surveillance System (NEISS) to evaluate sporting activities and the incidence of genitourinary (GU) injury. The NEISS is maintained by the US Consumer Product Safety Commission and links those injuries presenting to emergency departments with consumer products. Prior work has used this data set to evaluate injuries associated with a wide variety of consumer products ranging from batteries to trampolines. The authors of this study are to be congratulated on recognizing that the NEISS could be used more extensively to estimate the demographics of GU injury related...
Source: Urology - December 19, 2014 Category: Urology & Nephrology Authors: Jeremy B. Myers, William O. Brant, James M. Hotaling Tags: Reconstructive Urology Source Type: research

Sports-related Genitourinary Injuries Presenting to United States Emergency Departments
To describe epidemiologic features of sports-related genitourinary (GU) injuries and determine patient cohorts and particular sporting activities associated with increased GU injury risk. (Source: Urology)
Source: Urology - December 19, 2014 Category: Urology & Nephrology Authors: Herman S. Bagga, Patrick B. Fisher, Gregory E. Tasian, Sarah D. Blaschko, Charles E. McCulloch, Jack W. McAninch, Benjamin N. Breyer Tags: Reconstructive Urology Source Type: research

Reply
Thank you for your comments. Sporting injuries are indeed a significant source of genitourinary (GU) trauma resulting in US emergency department (ED) presentation. In fact, we found them the most common etiology of such GU injury over virtually every age range. It is important to note, however, that the very young (aged 65 years) were notable exceptions. In both of these cohorts, GU injury was more common in the bathroom, often due to trauma with bathroom fixtures, and in infants, due to hot water burns or irritation due to soaps. (Source: Urology)
Source: Urology - December 19, 2014 Category: Urology & Nephrology Authors: Herman S. Bagga Tags: Reconstructive Urology Source Type: research

Giant Pulmonary Chondroid Hamartoma: Imaging and Pathology Correlation of a Rare Tumor Demonstrated With Bone Scintigraphy and 18F-FDG PET/CT
AbstractA 35-year-old man presented to the emergency department with a worsening cough and a history of unintended weight loss. Chest radiograph revealed a giant mass occupying the left hemithorax. On CT scan, the mass measured over 20 cm and shifted the heart into the right hemithorax. Bone scan demonstrated multifocal radiotracer uptake within coarse intratumoral calcifications. Biopsy revealed no malignant cells. However, malignancy was clinically suspected due to size, and FDG PET/CT was performed. Mild FDG uptake was present in the mass. The mass was excised, and pathologic examination revealed the rare diagnosis of a...
Source: Clinical Nuclear Medicine - December 19, 2014 Category: Radiology Tags: Interesting Images Source Type: research

383: A prediction model for emergency caesarean section in women with placenta previa
Placenta previa (PP) complicates 0.4-0.8% of all pregnancies and is associated with emergency delivery (ED) by caesarean section (CS) with consequential maternal and neonatal morbidity and mortality. Knowledge of high risk categories in PP could help to avoid ED and enable earlier delivery planning or fetal lung maturation with corticosteroids in high risk cases. Currently there are no data to predict the risk of ED in patients with PP. The aim of this study is to identify risk factors for ED to differentiate low risk from high risk cases. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 19, 2014 Category: OBGYN Authors: Sanne Eschbach, Laura Ruiter, Mara Burgers, Katrien Oude Rengerink, Marielle G. van Pampus, Birgit van der Goes, Eva Pajkrt, Ben Willem Mol, Irene de Graaf Tags: Poster session II Source Type: research

402: Adverse outcomes of low risk pregnancies in the united states
In this study, we report the risk for adverse maternal and newborn outcomes among pregnancies without recorded prenatal risk factors. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 19, 2014 Category: OBGYN Authors: Valery Danilack, Anthony Nunes, Maureen Phipps Tags: Poster session II Source Type: research

472: Patient decision aid with individual risk estimation: an effective tool in choosing the mode of delivery after cesarean section
To evaluate the effectiveness of a decision aid (DA) for mode of delivery after prior cesarean section (CS) on patient involvement, vaginal birth (VB), elective and emergency CS rates. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 19, 2014 Category: OBGYN Authors: Emy Vankan, Ellen Schoorel, Sander van Kuijk, Robert Aardenburg, Friso Delemarre, Carmen Dirksen, Ivo van Dooren, Simone Kuppens, Anneke Kwee, Josje Langenveld, Ben Willem Mol, Rosella Hermens, Hubertina Scheepers Tags: Poster session III Source Type: research

Understanding interactions between Chinese medicines and pharmaceutical drugs in integrative healthcare
Abstract In the 21st century, the public are more informed, mainly via the Internet, about health and medical products and have become more knowledgeable about matters relating to their health conditions and well-being in curing and preventing illnesses. They often self-medicate themselves with various health products and over-the-counter (OTC) medicines apart from prescribed pharmaceutical drugs (PD). Some of those non-prescribed products may have doubtful quality control and contain harmful additives or unchecked ingredients; thus their usefulness is in doubt. The increasing popularity world-wide of using Chines...
Source: Chinese Journal of Integrative Medicine - December 19, 2014 Category: Internal Medicine Source Type: research

Evidence-based clinical practice manual: Postoperative controls
Conclusions This handbook comprises the basic guidelines for primary management of patients at the postoperative care unit. It may be amended or adapted according to the institutional requirements and for specific patient groups and is not intended to replace the existing protocols at the particular institution and does not define outcomes or prognosis. (Source: Colombian Journal of Anesthesiology)
Source: Colombian Journal of Anesthesiology - December 19, 2014 Category: Anesthesiology Source Type: research

Toothpick ingestion complicated by cecal perforation: case report and literature review
Conclusions: Foreign body ingestion should be taken into account in the evaluation of acute abdominal pain. A detailed patient's history may be crucial for a correct diagnosis and treatment. (Source: World Journal of Emergency Surgery)
Source: World Journal of Emergency Surgery - December 19, 2014 Category: Emergency Medicine Authors: Andrea LoveceEmanuele AstiAndrea SironiLuigi Bonavina Source Type: research

This Year, Don't Make Resolutions -- Create Habits
This article, written by Sarah Kaufman, originally appeared on Betterment. This is the year you're going to crush your resolutions. You're going to exercise five days a week, cut back on greasy foods, and save more -- a lot more -- money. You're going to feel motivated the whole time, so it will be simple. It's just a matter of adhering to your mission. Mind over matter. Right? Wrong. Around 45 percent of Americans make New Year's resolutions, according to a University of Scranton survey published in the Journal of Clinical Psychology, and yet just 8 percent achieve them. The first two weeks of the year are the easiest...
Source: Healthy Living - The Huffington Post - December 18, 2014 Category: Consumer Health Advice Source Type: news

Febrile Young Infants With Altered Urinalysis at Low Risk for Invasive Bacterial Infection. A Spanish Pediatric Emergency Research Network’s Study
Conclusions:We have derived a highly accurate prediction model for IBI in febrile infants with altered urinalysis. Given these results, outpatient management might be suitable for 1 of each 4 infants diagnosed, with a considerable improvement in resource utilization. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - December 18, 2014 Category: Infectious Diseases Tags: Original Studies Source Type: research

Increasing Pyomyositis Presentations Among Children in Queensland, Australia
Conclusion:This study demonstrates an increasing incidence of pyomyositis in a temperate region, which is not attributable to the emergence of CA-MRSA. The reasons for this change in incidence are not clear. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - December 18, 2014 Category: Infectious Diseases Tags: Original Studies Source Type: research

The Efficacy of Tranexamic Acid in Upper Gastrointestinal Hemorrhage: A Double-Blind Randomized Controlled Trial
Upper gastrointestinal haemorrhage is one of the major problems for which patients are brought to the emergency department. Endoscopy is the main diagnostic tool and treatment for upper gastrointestinal haemorrhage. Nevertheless, in regional hospitals, not every patient receives immediate endoscopy. Medical haemostasis might be beneficial during this period. Proton-pump inhibitors (PPIs) and octreotide analogues are widely used and proven useful. Tranexamic acid is an antifibrinolytic agent that is generally prescribed for multiple organ haemostasis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2014 Category: Gastroenterology Authors: Thitithep Limvorapitak, Apichat Piriyakarnon Tags: International digestive disease forum, Hong Kong, 2014 Source Type: research

Ebola: Who is Responsible for the Political Failures?
Editorial Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 553-554Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

Factors Associated with the Intention of Health Care Personnel to Respond to a Disaster
Research Articles Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 555-560Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

Hospital Disaster Response Using Business Impact Analysis
Research Articles Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 561-568Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

Using Mixed Methods to Assess Pediatric Disaster Preparedness in the Hospital Setting
Research Articles Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 569-575Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

The Use of FAST Scan by Paramedics in Mass-casualty Incidents: A Simulation Study
Research Articles Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 576-579Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

Evaluating Cold, Wind, and Moisture Protection of Different Coverings for Prehospital Maritime Transportation–A Thermal Manikin and Human Study
Research Articles Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 580-588Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

Swedish Ambulance Managers’ Descriptions of Crisis Support for Ambulance Staff After Potentially Traumatic Events
Research Articles Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 589-592Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

The Impact of Precipitation on Land Interfacility Transport Times
Research Articles Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 593-599Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

Integration of Energy Analytics and Smart Energy Microgrid into Mobile Medicine Operations for the 2012 Democratic National Convention
Research Articles Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 600-607Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

Comparison of Prediction Models for Use of Medical Resources at Urban Auto-racing Events
Research Articles Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 608-613Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

Streamlining of Medical Relief to Areas Affected by the Great East Japan Earthquake with the “Area-based/Line-linking Support System”
Research Articles Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 614-622Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

Improving Olympic Health Services: What are the Common Health Care Planning Issues?
Research Articles Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 623-628Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

Does Disaster Education of Teenagers Translate into Better Survival Knowledge, Knowledge of Skills, and Adaptive Behavioral Change? A Systematic Literature Review
Review Articles Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 629-642Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

Securing the Second Front: Achieving First Receiver Safety and Security through Competency-based Tools
Brief Report Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 643-647Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

Mass-gathering Health Research Foundational Theory: Part 1 - Population Models for Mass Gatherings
Brief Report Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 648-654Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

Mass-gathering Health Research Foundational Theory: Part 2 - Event Modeling for Mass Gatherings
Brief Report Prehospital and Disaster Medicine, Volume 29 Issue 06, pp 655-663Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

PDM volume 29 issue 6 Cover and Front matter
Miscellaneous Prehospital and Disaster Medicine, Volume 29 Issue 06, pp f1-f8Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

PDM volume 29 issue 6 Cover and Back matter
Miscellaneous Prehospital and Disaster Medicine, Volume 29 Issue 06, pp b1-b5Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - December 18, 2014 Category: Emergency Medicine Source Type: research

Measurement of circulating cell-free DNA levels by a simple fluorescent test in patients with breast cancer.
CONCLUSIONS: CFD measured using a simple fluorometric assay has shown good correlation to stage and enhanced sensitivity to locally advanced disease. A large prospective study is warranted to evaluate if inclusion of this method as a decisive marker before mammography is advantageous. PMID: 25511138 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - December 18, 2014 Category: Cancer & Oncology Authors: Agassi R, Czeiger D, Shaked G, Avriel A, Sheynin J, Lavrenkov K, Ariad S, Douvdevani A Tags: Am J Clin Pathol Source Type: research

Doxycycline Attenuates Renal Injury In A Swine Model Of Neonatal Hypoxia-Reoxygenation
ABSTRACT: Acute kidney injury in asphyxiated neonates is common. The renal protective effects of doxycycline, a known matrix metalloproteinase (MMP) inhibitor, have been demonstrated in rat ischemic-reperfusion models of injury. These effects have not been tested in large-animal models designed to reflect true clinical scenarios of neonatal hypoxia-reoxygenation (H-R). Newborn piglets were surgically instrumented for hemodynamic monitoring and subjected to 2 h of hypoxia followed by 4 h of normoxic reoxygenation. Piglets were blindly randomized to receive i.v. saline or doxycycline (3, 10, or 30 mg/kg) 5 min into reoxygena...
Source: Shock - December 18, 2014 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Extracellular Signal–Regulated Kinase–Mammalian Target of Rapamycin Signaling and Forkhead-Box Transcription Factor 3a Phosphorylation Are Involved in Testosterone’s Effect on Severe Burn Injury in a Rat Model
Conclusions: Results suggested that testosterone might regulate skeletal muscle glucose and protein metabolism following burn injury in part by affecting extracellular signal–regulated kinase–mTOR signaling and Foxo3a levels. (Source: Shock)
Source: Shock - December 18, 2014 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Low-Dose Cyclophosphamide Improves Survival in a Murine Treatment Model of Sepsis
ABSTRACT: Sepsis is a complex medical condition characterized by a systemic inflammatory response in the setting of infection. We hypothesized that combining antibiotics plus an immunosuppressant would protect against the morbidity and mortality of polymicrobial sepsis in mice better than would antibiotics alone. We used a murine cecal-ligation-and-puncture model in which mice were treated either with imipenem plus cyclophosphamide or imipenem alone. Titration to a low cyclophosphamide dose revealed that combination therapy increased survival by 20% compared with imipenem alone (56% vs. 36%, P < 0.001). To investigate the ...
Source: Shock - December 18, 2014 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Coagulation Phenotypes in Septic Shock as Evaluated by Calibrated Automated Thrombography
ABSTRACT: Sepsis induces alterations of coagulation suggesting both hypercoagulable or hypocoagulable features. The result of their combination remains unknown, making it difficult to predict whether one prevails over the other. Thrombin generation tests (TGTs) stand as an interesting tool to establish an integrative phenotype of coagulation. It has been reported that septic patients display a hypocoagulable trait using TGT. However, protein C (PC) system response was not evaluated. We aimed at describing the thrombin generation profile in patients with septic shock under conditions that are sensitive to PC system to evalu...
Source: Shock - December 18, 2014 Category: Emergency Medicine Tags: Clinical Aspects Source Type: research

Alcohol Potentiates Postburn Remote Organ Damage Through Shifts in Fluid Compartments Mediated by Bradykinin
ABSTRACT: Of the 450,000 burn patients each year, 50% have a positive blood alcohol content, and this predisposes them to worsened clinical outcomes. Despite high prevalence and established consequences, the mechanisms responsible for alcohol-mediated complications of postburn remote organ damage are currently unknown. To this end, mice received a single dose of alcohol (1.12 g/kg) or water by oral gavage and were subjected to a 15% total body surface area burn. Animals with a burn alone lost ∼5% of their body weight in 24 h, whereas intoxicated and burned mice lost only 1% body weight (P < 0.05) despite a 17% increase i...
Source: Shock - December 18, 2014 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Bacterial Translocation and Plasma Cytokines During Transcatheter and Open-Heart Aortic Valve Implantation
Conclusions: Compared with OHAVR, TAVI was associated with decreases in bacterial translocation and inflammation. These differences may explain the lower delirium rate and better hemodynamic stability observed, despite the greater disease severity in TAVI patients. (Source: Shock)
Source: Shock - December 18, 2014 Category: Emergency Medicine Tags: Clinical Aspects Source Type: research

Fluid Overload in Patients With Severe Sepsis and Septic Shock Treated With Early Goal-Directed Therapy Is Associated With Increased Acute Need for Fluid-Related Medical Interventions and Hospital Death
ABSTRACT: Early goal-directed therapy (EGDT) consists of early, aggressive fluid resuscitation and is known to improve survival in sepsis. It is unknown how often EGDT leads to subsequent fluid overload and whether post-EGDT fluid overload affects patients’ outcomes. Our hypothesis was that patients with sepsis treated with EGDT were at risk for fluid overload and that fluid overload would be associated with adverse outcomes. We conducted a retrospective cohort of 405 consecutive patients admitted with severe sepsis and septic shock to the medical intensive care unit of a tertiary care academic hospital from January 2008...
Source: Shock - December 18, 2014 Category: Emergency Medicine Tags: Clinical Aspects Source Type: research

The Impact of Serial Lactate Monitoring on Emergency Department Resuscitation Interventions and Clinical Outcomes in Severe Sepsis and Septic Shock: An Observational Cohort Study
ABSTRACT: Monitoring in the setting of critical illness must be linked to beneficial therapy to affect clinical outcome. Elevated serum lactate is associated with an increase in mortality in emergency department (ED) patients with severe sepsis and septic shock. The reduction of lactate levels toward normal during acute resuscitation is associated with improved clinical outcomes. The majority of data demonstrating the interventions used to achieve a reduction in lactate levels and the associated clinical outcomes have been obtained during protocolized randomized trials. We therefore conducted a retrospective observational ...
Source: Shock - December 18, 2014 Category: Emergency Medicine Tags: Clinical Aspects Source Type: research

Hemolysis Exacerbates Hyperfibrinolysis, Whereas Platelolysis Shuts Down Fibrinolysis: Evolving Concepts of the Spectrum of Fibrinolysis in Response to Severe Injury
Conclusion: Red blood cell lysate is a potent enhancer of fibrinolysis, whereas platelet lysate inhibits fibrinolysis. Intracellular proteins from circulating blood cells contain proteins that interact with the two key proteins of tPA-mediated fibrinolysis. Understanding the effect of tissue injury and shock on the lysis of circulating cells may provide insight to comprehending the spectrum of fibrinolysis in response to trauma. (Source: Shock)
Source: Shock - December 18, 2014 Category: Emergency Medicine Tags: 2014 New Investigator Award Competition Source Type: research

Programmed Cell Death Receptor Ligand 1 Modulates the Regulatory T Cells’ Capacity to Repress Shock/Sepsis–Induced Indirect Acute Lung Injury by Recruiting Phosphatase Src Homology Region 2 Domain-Containing Phosphatase 1
In this study, we further determine whether recipient mouse lacking PD-L1, one of the primary ligands for PD-1, contributes to the manipulation of the Tregs’ capacity to repress lung injury. To do this, Tregs isolated from the spleen of WT mice were AT into PD-L1−/− mice subjected to hemorrhagic shock and subsequent to cecal ligation and puncture to induce iALI. Samples were collected for analyses 24 h after cecal ligation and puncture. We found that in PD-L1−/−–recipient mice, AT WT-Tregs lost the ability to reverse the development of iALI seen in WT recipient mice (i.e., no reduction of lung injury indices as...
Source: Shock - December 18, 2014 Category: Emergency Medicine Tags: 2014 New Investigator Award Competition Source Type: research

Blocking Cold-Inducible RNA-Binding Protein Protects Liver From Ischemia-Reperfusion Injury
ABSTRACT: Cold-inducible RNA-binding protein (CIRP) is a nuclear protein that has been recently identified as a novel inflammatory mediator in hemorrhagic shock and sepsis. We hypothesized that CIRP acts as a potent inflammatory mediator in hepatic ischemia-reperfusion (I/R), and thus blocking CIRP protects against I/R-induced liver injury. Male C57BL/6 mice were subjected to 70% hepatic ischemia by microvascular clamping of the hilum of the left and median liver lobes for 60 min, followed by reperfusion. Anti-CIRP antibody (1 mg/kg body weight) or vehicle (normal saline) in 0.2 mL was injected via the internal jugular vei...
Source: Shock - December 18, 2014 Category: Emergency Medicine Tags: 2014 New Investigator Award Competition Source Type: research

Role of Surfactant Proteins A and D in Sepsis-Induced Acute Kidney Injury
ABSTRACT: Sepsis is a major cause of acute kidney injury (AKI) with high rates of morbidity and mortality. Surfactant proteins A and D (SP-A, SP-D) play a critical role in host defense and regulate inflammation during infection. Recent studies indicate SP-A and SP-D are expressed in the kidney. The current study examines the role of SP-A and SP-D in the pathogenesis of sepsis-induced AKI. Wild-type (WT) and SP-A/SP-D double-knockout (KO) C57BL/6 mice were treated by cecal ligation and puncture (CLP) or sham surgery. Histological, cellular, and molecular indices of kidney injury were investigated in septic mice 6 and 24 h a...
Source: Shock - December 18, 2014 Category: Emergency Medicine Tags: 2014 New Investigator Award Competition Source Type: research

Dysregulation of Intracellular Calcium Transporters in Animal Models of Sepsis-Induced Cardiomyopathy
In conclusion, substantial cumulative evidence implicates various Ca2+ transporters and the myofilaments in SIC pathology. What is less clear, however, are the identity and interplay of the signaling pathways that are responsible for Ca2+ transporters dysfunction. With few exceptions, all studies we found used solely male animals. Identifying sex differences in Ca2+ dysregulation in SIC becomes, therefore, another priority. (Source: Shock)
Source: Shock - December 18, 2014 Category: Emergency Medicine Tags: Review Article Source Type: research