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Glucose-lowering therapy in diabetes ‘slows vasculopathy progression’Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glucose-lowering therapy in people with diabetes improves the structure and function of the vasculature, which in turn helps slow the progression of coronary artery calcification, research suggests. (Source: MedWire News - Diabetes)
Source: MedWire News - Diabetes - November 21, 2009 Category: Endocrinology Source Type: news

November Is Diabetes Awareness Month, But Independence Blue Cross Fights This Growing And Devastating Disease Every DayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
IBC received one of the top corporate team awards from the American Diabetes Association (ADA) after mobilizing a team of nearly 400 walkers who raised $36,000 through donations and its corporate matching gift program for the ADA's Step Out: Walk to Fight Diabetes presented by Independence Blue Cross (IBC). This fall, more than 3,500 people gathered to participate in the ADA's signature fundraising walk that takes place in 160 cities across the country. (Source: Diabetes News From Medical News Today)
Source: Diabetes News From Medical News Today - November 21, 2009 Category: Endocrinology Tags: Diabetes Source Type: news

Unaware And At-RiskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The incidence of Type 2 diabetes has increased significantly over the last two decades, affecting both women and men alike. Obesity, often the result of unhealthy diets and lack of exercise, is a major contributor to the development of Type 2 diabetes. But despite the large number of cases diagnosed in the United States, many Americans still lack basic knowledge about the disease. (Source: Diabetes News From Medical News Today)
Source: Diabetes News From Medical News Today - November 21, 2009 Category: Endocrinology Tags: Diabetes Source Type: news

KineMed Receives An Investigator-Initiated Study Grant To Further Explore Mechanism(s) Of Action Associated With Welchol® In Type 2 Diabetes MelliEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
KineMed, Inc., a translational and personalized medicine development company, announced today that the company has received an investigator initiated study grant from Daiichi Sankyo, Inc. to conduct a clinical study designed to better understand and characterize the beneficial effects of Welchol® (colesevelam HCl) in patients with Type 2 Diabetes Mellitus (T2DM). (Source: Diabetes News From Medical News Today)
Source: Diabetes News From Medical News Today - November 21, 2009 Category: Endocrinology Tags: Diabetes Source Type: news

Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, long-term therapy with FEN partially prevents or reverses obesity, insulin resistance, and hepatic steatosis in mice on HFD. The anti-adiposity effects are independent of the RBP4 lowering effect. (Source: AJP: Endocrinology and Metabolism)
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Preitner, F., Mody, N., Graham, T. E., Peroni, O. D., Kahn, B. B. Tags: Articles Source Type: journals

Lactate distribution in culture medium of human myometrial biopsies incubated under different conditionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is generally believed that a relationship exists between muscle fatigue and intracellular accumulation of lactate. This reasoning is relevant to obstetrical issues. Myocytes in uterus work together during labor, and the contractions need to be strong and synchronized for a child to be delivered. At labor dystocia, the progress of labor becomes slow or arrested after a normal beginning. It has been described that, during labor dystocia, when the force of the contractions is low, the uterus is under hypoxia, and anaerobic conditions with high levels of lactate in amniotic fluid dominate. The purpose of this study was to e...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Akerud, H., Ronquist, G., Wiberg-Itzel, E. Tags: Articles Source Type: journals

Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The adipocyte-specific protein FSP27, also known as CIDEC, is one of three cell death-inducing DFF45-like effector (CIDE) proteins. The first known function for CIDEs was promotion of apoptosis upon ectopic expression in mammalian cells. Recent studies in endogenous settings demonstrated key roles for CIDEs in energy metabolism. FSP27 is a lipid droplet-associated protein whose heterologous expression enhances formation of enlarged lipid droplets and is required for unilocular lipid droplets typical of white adipocytes in vivo. Here, we delineate relationships between apoptotic function and lipid droplet localization of FS...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Liu, K., Zhou, S., Kim, J.-Y., Tillison, K., Majors, D., Rearick, D., Lee, J. H., Fernandez-Boyanapalli, R. F., Barricklow, K., Houston, M. S., Smas, C. M. Tags: Articles Source Type: journals

Role of the AMPK{gamma}3 isoform in hypoxia-stimulated glucose transport in glycolytic skeletal muscleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Skeletal muscle glucose transport is regulated via the canonical insulin-signaling cascade as well as by energy-sensing signals. 5'-AMP-activated protein kinase (AMPK) has been implicated in the energy status regulation of glucose transport. We determined the role of the AMPK3 isoform in hypoxia-mediated energy status signaling and glucose transport in fast-twitch glycolytic extensor digitorum longus (EDL) muscle from AMPK3-knockout (KO) mice and wild-type mice. Although hypoxia increased glucose transport (P < 0.001) in wild-type mice, this effect was attenuated in AMPK3-KO mice (45% reduction, P < 0.01). The role o...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Deshmukh, A. S., Glund, S., Tom, R. Z., Zierath, J. R. Tags: Articles Source Type: journals

Pigment epithelium-derived factor suppresses adipogenesis via inhibition of the MAPK/ERK pathway in 3T3-L1 preadipocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We previously reported that circulating levels of pigment epithelium-derived factor (PEDF), a newly identified adipokine, are increased in patients with type 2 diabetes, correlating with body mass index. However, the role of PEDF in adipogenesis remains elusive. In the present study, we have investigated the effects and mechanisms of PEDF on adipocyte differentiation in 3T3-L1 preadipocytes. Differentiation of 3T3-L1 preadipocytes was induced in the presence or absence of human recombinant PEDF protein. The effects of PEDF on adipogenic gene expression, mitotic clonal expansion (MCE), and MAPK activation were investigated....
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Wang, M., Wang, J. J., Li, J., Park, K., Qian, X., Ma, J.-x., Zhang, S. X. Tags: Articles Source Type: journals

Attenuation of diabetes-induced renal dysfunction by multiple exposures to low-dose radiation is associated with the suppression of systemic and renal inflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Renal protection against diabetes-induced pathogenic injuries by multiple exposures to low-dose radiation (LDR) was investigated to develop a novel approach to the prevention of renal disease for diabetic subjects. C57BL/6J mice were given multiple low-dose streptozotocin (STZ; 60 x 6 mg/kg) to produce a type 1 diabetes. Two weeks after diabetes onset, some of diabetic mice and age-matched nondiabetic mice were exposed whole body to 25 mGy X-rays every other day for 2, 4, 8, 12, and 16 wk. Diabetes caused a significant renal dysfunction, shown by time-dependent increase in urinary microalbumin (Malb) and decrease in urinar...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Zhang, C., Tan, Y., Guo, W., Li, C., Ji, S., Li, X., Cai, L. Tags: Articles Source Type: journals

Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glucose ingestion stimulates the secretion of the incretin hormones, glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1). Despite the critical role of incretins in glucose homeostasis, the mechanism of glucose-induced incretin secretion has not been established. We investigated the underlying mechanism of glucose-induced incretin secretion in vivo in mice. Injection of glucose at 1 g/kg in the upper intestine significantly increased plasma GIP and GLP-1 levels, whereas injection of glucose in the colon did not increase GIP or GLP-1 levels. This finding indicates that the glucose sensor for gl...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Moriya, R., Shirakura, T., Ito, J., Mashiko, S., Seo, T. Tags: Articles Source Type: journals

Changed mitochondrial function by pre- and/or postpartum diet alterations in sheepEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined mitochondrial function in permeabilized muscle fibers from the lambs at 6 mo of age (adolescence) and after 24 mo of age (adulthood). The postpartum H diet for the lambs induced an ~30% increase (P < 0.05) of mitochondrial Vo2max and an ~50% increase (P < 0.05) of the respiratory coupling ratio (RCR) combined with lower levels of UCP3 and PGC-1 mRNA levels (P < 0.05). These effects proved to be reversible by a normal diet from 6 to 24 mo of age. However, at 24 mo, a long-term effect of the maternal gestational diet restriction (fetal programming) became evident as a lower Vo2max (~40%, P < 0.05), a ...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Jorgensen, W., Gam, C., Andersen, J. L., Schjerling, P., Scheibye-Knudsen, M., Mortensen, O. H., Grunnet, N., Nielsen, M. O., Quistorff, B. Tags: Articles Source Type: journals

Chronically elevated plasma C-type natriuretic peptide level stimulates skeletal growth in transgenic miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
C-type natriuretic peptide (CNP) plays a critical role in endochondral ossification through guanylyl cyclase-B (GC-B), a natriuretic peptide receptor subtype. Cartilage-specific overexpression of CNP enhances skeletal growth and rescues the dwarfism in a transgenic achondroplasia model with constitutive active mutation of fibroblast growth factor receptor-3. For future clinical application, the efficacy of CNP administration on skeletal growth must be evaluated. Due to the high clearance of CNP, maintaining a high concentration is technically difficult. However, to model high blood CNP concentration, we established a liver...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Kake, T., Kitamura, H., Adachi, Y., Yoshioka, T., Watanabe, T., Matsushita, H., Fujii, T., Kondo, E., Tachibe, T., Kawase, Y., Jishage, K.-i., Yasoda, A., Mukoyama, M., Nakao, K. Tags: Articles Source Type: journals

Quantification of pancreatic islet distribution in situ in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tracing changes of specific cell populations in health and disease is an important goal of biomedical research. Precisely monitoring pancreatic β-cell proliferation and islet growth is a challenging area of research. We have developed a method to capture the distribution of β-cells in the intact pancreas of transgenic mice with fluorescence-tagged β-cells with a macro written for ImageJ (rsb.info.nih.gov/ij/). Total β-cell area and islet number and size distribution are quantified with reference to specific parameters and location for each islet and for small clusters of β-cells. The entire distrib...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Kilimnik, G., Kim, A., Jo, J., Miller, K., Hara, M. Tags: Innovative Methodology Source Type: journals

VLDL-TG kinetics: a dual isotope study for quantifying VLDL-TG pool size, production rates, and fractional oxidation in humansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Very-low-density lipoproteins (VLDLs) are large, complex particles containing both surface proteins (e.g., ApoB100) and core lipids, e.g., cholesterol and triglycerides (TG). Whereas ApoB100 kinetics have been thoroughly studied, accurate measurement of VLDL-TG kinetics have proven difficult due to either complex mathematics or laborious procedures. The present study was therefore designed to measure VLDL-TG kinetics by dual isotope ex vivo labeled VLDL-TG tracers and well-established kinetics equations (bolus injection or the primed continuous infusion). Ten healthy Caucasian men [age, 23 ± 3 yr old (mean ± ...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Sorensen, L. P., Gormsen, L. C., Nielsen, S. Tags: Articles Source Type: journals

mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the ratEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Three transduction pathways are involved in amino acid (AA) sensing in liver: mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), and general control nondepressible kinase 2 (GCN2). However, no study has investigated the involvement of these signaling pathways in hepatic AA sensing. To address the question of liver AA sensing and signaling in response to a high-protein (HP) dietary supply, we investigated the changes in the phosphorylation state of hepatic mTOR (p-mTOR), AMPK (p-AMPK), and GCN2 (p-GCN2) by Western blotting. In rats fed a HP diet for 14 days, the hepatic p-AMPK and p-GCN2 were lower (...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Chotechuang, N., Azzout-Marniche, D., Bos, C., Chaumontet, C., Gausseres, N., Steiler, T., Gaudichon, C., Tome, D. Tags: Articles Source Type: journals

Deletion of Fas in the pancreatic {beta}-cells leads to enhanced insulin secretionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to determine the role of Fas specifically in β-cells under both physiological and diabetes models. Mice with Fas deletion specifically in the β-cells were generated using the Cre-loxP system. Cre-mediated Fas deletion was under the control of the rat insulin promoter. Absence of Fas in β-cells leads to complete protection against FasL-induced cell death. However, Fas is not essential in determining β-cell mass or susceptibility to streptozotocin- or HFD-induced diabetes. Importantly, Fas deletion in β-cells leads to increased p65 expression, enhanced glucose tolerance...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Choi, D., Radziszewska, A., Schroer, S. A., Liadis, N., Liu, Y., Zhang, Y., Lam, P. P. L., Sheu, L., Hao, Z., Gaisano, H. Y., Woo, M. Tags: Articles Source Type: journals

Different impacts of saturated and unsaturated free fatty acids on COX-2 expression in C2C12 myotubesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In skeletal muscle, saturated free fatty acids (FFAs) act as proinflammatory stimuli, and cyclooxygenase-2 (COX-2) is a pro/anti-inflammatory enzyme induced at sites of inflammation, which contributes to prostaglandin production. However, little is known about the regulation of COX-2 expression and its responses to FFAs in skeletal muscle. Herein, we examined the effects of saturated and unsaturated FFAs, including a recently identified lipokine (lipid hormone derived from adipocytes), palmitoleate, on COX-2 expression in C2C12 myotubes as a skeletal muscle model. Exposure of myotubes to saturated FFAs [palmitate (16:0) an...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Kadotani, A., Tsuchiya, Y., Hatakeyama, H., Katagiri, H., Kanzaki, M. Tags: Articles Source Type: journals

USP19-deubiquitinating enzyme regulates levels of major myofibrillar proteins in L6 muscle cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The ubiquitin-proteasome system plays an important role in the degradation of myofibrillar proteins that occurs in muscle wasting. Many studies have demonstrated the importance of enzymes mediating conjugation of ubiquitin. However, little is known about the role of deubiquitinating enzymes. We previously showed that the USP19-deubiquitinating enzyme is induced in atrophying skeletal muscle (Combaret L, Adegoke OA, Bedard N, Baracos V, Attaix D, Wing SS. Am J Physiol Endocrinol Metab 288: E693–E700, 2005). To further explore the role of USP19, we used small interfering RNA (siRNA) in L6 muscle cells. Lowering USP19 b...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Sundaram, P., Pang, Z., Miao, M., Yu, L., Wing, S. S. Tags: Articles Source Type: journals

A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Platelet-activating factor (PAF) and lysophosphatidylcholine (LPC) are potent inflammatory lipids. Elevated levels of PAF and LPC are associated with the onset of diabetic retinopathy and neurodegeneration. However, the molecular mechanisms underlying such defects remain elusive. LPCAT1 is a newly reported lysophospholipid acyltransferase implicated in the anti-inflammatory response by its role in conversion of LPC to PC. Intriguingly, the LPCAT1 enzyme also catalyzes the synthesis of PAF from lyso-PAF with use of acetyl-CoA as a substrate. The present studies investigated regulatory roles of LPCAT1 in the synthesis of inf...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Cheng, L., Han, X., Shi, Y. Tags: Articles Source Type: journals

Regulation of food intake and body weight by recombinant proghrelinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ghrelin is a 28-amino-acid hormone derived from the endoproteolytic processing of its prehormone proghrelin. Although ghrelin has been reported to regulate food intake and body weight, it is still unknown whether proghrelin exercises any biological function. Here we show that recombinant proghrelin alters food intake and energy metabolism in mice. After intraperitoneal administration of recombinant proghrelin (100 nmol/kg body wt), cumulative food intake was significantly increased at days 1, 2, and 3 (6 ± 0.3, 13 ± 0.5, and 20 ± 0.8 g vs. 5 ± 0.2, 10 ± 0.2, and 16 ± 0.3 g of the c...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Zhang, W., Majumder, A., Wu, X., Mulholland, M. W. Tags: Articles Source Type: journals

Short-term prednisone use antagonizes insulin's anabolic effect on muscle protein and glucose metabolism in young healthy peopleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glucocorticoids cause muscle atrophy and weakness, but the mechanisms for these effects are unclear. The purpose of this study was to test a hypothesis that prednisone (Pred) counteracts insulin's anabolic effects on muscle. A randomized, double-blind cross-over design was used to test the effects of 6 days either Pred (0.8 mg·kg–1·day–1) or placebo use in seven healthy young volunteers. Protein dynamics were measured across the leg using stable isotope tracers of leucine (Leu) and phenylalanine (Phe) after overnight fast and during a hyperinsulinemic (1.5 µU·min–1·kg FFM...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Short, K. R., Bigelow, M. L., Nair, K. S. Tags: Articles Source Type: journals

Recent advances in understanding leptin signaling and leptin resistanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The brain controls energy homeostasis and body weight by integrating various metabolic signals. Leptin, an adipose-derived hormone, conveys critical information about peripheral energy storage and availability to the brain. Leptin decreases body weight by both suppressing appetite and promoting energy expenditure. Leptin directly targets hypothalamic neurons, including AgRP and POMC neurons. These leptin-responsive neurons widely connect to other neurons in the brain, forming a sophisticated neurocircuitry that controls energy intake and expenditure. The anorexigenic actions of leptin are mediated by LEPRb, the long form o...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Morris, D. L., Rui, L. Tags: Reviews Source Type: journals

Translational implications of nongenomic actions of thyroid hormone initiated at its integrin receptorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A thyroid hormone receptor on integrin vβ3 that mediates cell surface-initiated nongenomic actions of thyroid hormone on tumor cell proliferation and on angiogenesis has been described. Transduction of the hormone signal into these recently recognized proliferative effects is by extracellular-regulated kinases 1/2 (ERK1/2). Other nongenomic actions of the hormone may be transduced by phosphatidylinositol 3-kinase (PI3K) and are initiated in cytoplasm or at the cell surface. PI3K-mediated effects are important to angiogenesis or other recently appreciated cell functions but apparently not to tumor cell division. For th...
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Davis, P. J., Davis, F. B., Lin, H.-Y., Mousa, S. A., Zhou, M., Luidens, M. K. Tags: 2009 Solomon Berson Award Lecture Source Type: journals

The search for the membrane thyroid hormone receptorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: AJP: Endocrinology and Metabolism)
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Samson, W. K. Tags: Editorial Focus Source Type: journals

Follicular origins of modern reproductive endocrinologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This essay looks at the historical significance of the APS Classic Paper: Allen E, Doisy EA. The induction of a sexually mature condition in immature females by injection of the ovarian follicular hormone. Am J Physiol 69: 577–588, 1924 (http://ajplegacy.physiology.org/cgi/reprint/69/3/577). (Source: AJP: Endocrinology and Metabolism)
Source: AJP: Endocrinology and Metabolism - November 20, 2009 Category: Endocrinology Authors: Stephens, S. M., Moley, K. H. Tags: Essays on APS Classic Papers Source Type: journals

Protamine-based insulin non-inferior to detemir for glycemic controlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel insulin formulation, insulin lispro protamine suspension, is non-inferior to insulin detemir for improving glycemic control in patients with Type 2 diabetes that is poorly controlled on oral hypoglycemic drugs, a randomized trial has shown. (Source: MedWire News - Diabetes)
Source: MedWire News - Diabetes - November 20, 2009 Category: Endocrinology Source Type: news

SfE BES 2010: Call for clinical cases and basic science issuesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deadline for basic science and clinical submissions: 18 January 2010. Further information (Source: SfE - Dates and Deadlines)
Source: SfE - Dates and Deadlines - November 20, 2009 Category: Endocrinology Source Type: events

Invitation for Basic Science and Clinical Cases - SfE BES 2010Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New for SfE BES 2010 - Invitation for basic science cases For SfE BES 2010, the Society is introducing a number of Basic Science Meet the Expert sessions. These will be relatively informal sessions with discussion based around new basic science technologies. If you would like to submit a specific issue to be discussed by the experts, please send a synopsis of the issue in a Word document (max. 300 words) to: conferences@endocrinology.org. The Basic Science Meet the Expert sessions will include: Metabolomics:challenges and rewards of deciphering the metabolome in diabetes and obesity; Resources in bioinformatics-How can it...
Source: Society for Endocrinology - November 20, 2009 Category: Endocrinology Source Type: organizations

Echo Therapeutics Announces Positive Results Of A Clinical Study Testing Symphony(TM) TCGM System In Patients With Type 1 And Type 2 DiabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Echo Therapeutics, Inc. (OTC Bulletin Board: ECTE), a company developing its needle-free Symphony(TM) tCGM System as a non-invasive, wireless, transdermal continuous glucose monitoring (tCGM) system and the Prelude(TM) SkinPrep System for transdermal drug delivery, today announced positive results of a clinical study of its Symphony tCGM System in patients with Type 1 and Type 2 Diabetes. (Source: Diabetes News From Medical News Today)
Source: Diabetes News From Medical News Today - November 20, 2009 Category: Endocrinology Tags: Diabetes Source Type: news

Islet Cell Transplantation In ScotlandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Scottish National Blood Transfusion Service has opened a new laboratory in Edinburgh to offer around 12 people a year islet cell transplant therapy. Islet cell transplant therapy is a pioneering treatment for diabetes that was part-funded by Diabetes UK in its research stages. About islets Islets are groups of cells in the pancreas that contain the insulin-producing beta cells. (Source: Diabetes News From Medical News Today)
Source: Diabetes News From Medical News Today - November 20, 2009 Category: Endocrinology Tags: Diabetes Source Type: news

American Diabetes Association Launches New Diabetes.org, Building A Community Of Help, Hope And SupportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To meet the changing needs of people affected by this growing epidemic, the American Diabetes Association has launched a completely redesigned http://www.diabetes.org in English and Spanish. Even though diabetes is a growing epidemic, a recent survey conducted by the Association showed that Americans received a failing grade in diabetes awareness. (Source: Diabetes News From Medical News Today)
Source: Diabetes News From Medical News Today - November 20, 2009 Category: Endocrinology Tags: Diabetes Source Type: news

More Obesity, Diabetes in South, AppalachiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: More Obesity, Diabetes in South, AppalachiaCategory: Health NewsCreated: 11/20/2009 11:08:00 AMLast Editorial Review: 11/20/2009 11:08:03 AM (Source: MedicineNet Diabetes General)
Source: MedicineNet Diabetes General - November 20, 2009 Category: Endocrinology Source Type: consumer

Long sleep duration may increase risk for Type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Long sleep duration is associated with increased risk for Type 2 diabetes, but the excess risk may be at least partly ameliorated by weight reduction, improved diet, and increased physical activity, say researchers. (Source: MedWire News - Diabetes)
Source: MedWire News - Diabetes - November 20, 2009 Category: Endocrinology Source Type: news

Unapproved SARM Drug Turns Up on Black MarketEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A failed drug candidate for muscle wasting in cancer patients now appears to be making a comeback as an illicit performance-enhancing drug for bodybuilders and fitness enthusiasts. (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - November 19, 2009 Category: Endocrinology Source Type: news

Influence of Fructose Concentration on Myocardial Infarction in Senile Diabetic and Non-diabetic PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aims to determine the fructose concentration and correlate with antioxidant status in senile diabetic and non-diabetic patients with myocardial infarction.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 19, 2009 Category: Endocrinology Tags: Article Source Type: journals

Comparative Study of Low-dose Pioglitazone or Metformin Treatment in Japanese Diabetic Patients with Metabolic SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol Diabetes 2009; 117: 593-599DOI: 10.1055/s-0029-1202792AbstractThe aim of this study was to determine whether a relatively low dose of pioglitazone or metformin was effective in diabetic patients with metabolic syndrome. Fifty diabetic patients with metabolic syndrome were randomly assigned to a low-dose pioglitazone (15 mg/day) treatment group or a low-dose metformin (500 mg/day) treatment group. Drugs were administered for 12 weeks. Systolic and diastolic blood pressure, heart rate, body mass index, triglyceride (TG), HDL and LDL-cholesterol, fasting plasma glucose (FPG), fasting plasma ins...
Source: Experimental and Clinical Endocrinology and Diabetes - November 19, 2009 Category: Endocrinology Tags: Article Source Type: journals

Evaluation of Beta Cell Dysfunction by Mixed Meal Tolerance Test and Oral L-arginine in Patients with Newly Diagnosed Type 2 Diabetes MellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol Diabetes 2009; 117: 573-576DOI: 10.1055/s-0029-1234087Abstract Defective insulin secretion is required for the development of frank diabetes mellitus. We evaluated the secretory response of pancreatic beta cells after the ingestion of mixed meal plus oral L-arginine in newly diagnosed type 2 diabetic patients.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 19, 2009 Category: Endocrinology Tags: Article Source Type: journals

Obesity and CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol Diabetes 2009; 117: 563-566DOI: 10.1055/s-0029-1241870AbstractEpidemiological studies have suggested that obesity is associated with increased risk of several cancer types including colon, esophagus, breast (in postmenopausal women), endometrium, kidney, liver, gallbladder and pancreas. Suggested mechanisms include increased intake of potentially carcinogenic food ingredients along with excessive amount of calories, loss of cancer protective effects due to reduced physical activity, carcinogenic factors released from increased adipose tissue mass and “secondary” associations via “precu...
Source: Experimental and Clinical Endocrinology and Diabetes - November 19, 2009 Category: Endocrinology Tags: Mini-Review Source Type: journals

Diabetes, Obesity, Insulin Resistance: Different Pathways to Cancer?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol Diabetes 2009; 117: 561-562DOI: 10.1055/s-0029-1241797© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - November 19, 2009 Category: Endocrinology Tags: Editorial Source Type: journals

Low-dose aspirin therapy shows no CVD benefit for Type 2 diabeticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results from a Chinese study show that low-dose aspirin therapy appears to convey no benefits for primary or secondary cardiovascular disease prevention for Type 2 diabetes patients. (Source: MedWire News - Diabetes)
Source: MedWire News - Diabetes - November 19, 2009 Category: Endocrinology Source Type: news

Glucokinase and Glucokinase Regulatory Proteins are Functionally Coexpressed before Birth in the Rat BrainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Our previous description of functional glucokinase (GK) isoforms and their interactions with glucokinase regulatory protein (GKRP) in adult rat and human brains suggested that both participate in glucose sensing in the central nervous system. To determine whether both proteins are coexpressed and active before birth or during early post-natal life, we characterised these molecules in the brains of foetal and post-natal pup rats. We found GK and GKRP mRNAs that were similar to those previously reported in the adult rat brain. Likewise, GK and GKRP gene expression gave rise to proteins of 52 and 69 kDa, respectively. Immunoh...
Source: Journal of Neuroendocrinology - November 19, 2009 Category: Endocrinology Authors: I. Roncero, C. Sanz, E. Álvarez, P. Vázquez, P.A. Barrio, E. Blázquez Tags: Original Articles Source Type: journals

Preeclampsia Tied to Future Thyroid Issues (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women who develop preeclampsia during pregnancy are at increased risk of hypothyroidism later in life, researchers said. (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - November 19, 2009 Category: Endocrinology Source Type: news

Senior Clinical Fellow in Endocrine Surgery, LondonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Via healthjobsuk.com. King's College Hospital NHS Foundation Trust have a vacancy for a Senior Clinical Fellow in Endocrine Surgery. The 6 month post is designed to underpin the clinical activities of the endocrine surgery team on the King’s Campus whilst we encourage participation in our newly initiated basic science/translational research portfolio. The post is designed to provide end-grade specialty training in endocrine surgery on a senior SpR/pre-consultant level. A transition of the post-holder into an engagement on longer terms is not excluded, but rather welcome provided a suitable skill set is identified. ...
Source: Society for Endocrinology - November 19, 2009 Category: Endocrinology Source Type: organizations

Tackling Diabetes Bullying, UKEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
From 16 to 20 November it is National Anti-Bullying Week, a campaign run by the Anti-Bullying Alliance to raise awareness of bullying and to send the clear message that it is neither acceptable nor inevitable. The theme this year is 'Stay safe in cyberspace', as a recent survey found that more than a third of 12- to 15-year-olds have faced some form of cyberbullying (the use of information technology such as mobile phones and the internet to upset and hurt people). (Source: Diabetes News From Medical News Today)
Source: Diabetes News From Medical News Today - November 19, 2009 Category: Endocrinology Tags: Diabetes Source Type: news

Two Thirds Of Brits Do Not Know The Difference Between Type 1 And Type 2 DiabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New research out today reveals that less than a third of UK residents (30 per cent) know of type 1 diabetes with a further 59 per cent confusing the autoimmune condition with type 2 diabetes - which can be related to obesity and lack of exercise. Men are the most uneducated about the condition, with only 28 per cent correctly identifying it compared with 32 per cent of women. (Source: Diabetes News From Medical News Today)
Source: Diabetes News From Medical News Today - November 19, 2009 Category: Endocrinology Tags: Diabetes Source Type: news

Lifelong Exercise Keeps Seniors Young at HeartEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Lifelong Exercise Keeps Seniors Young at HeartCategory: Health NewsCreated: 11/18/2009 4:10:00 PMLast Editorial Review: 11/19/2009 (Source: MedicineNet Diabetes General)
Source: MedicineNet Diabetes General - November 19, 2009 Category: Endocrinology Source Type: consumer

No Increased Pregnancy Risk for MS PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: No Increased Pregnancy Risk for MS PatientsCategory: Health NewsCreated: 11/19/2009 10:42:00 AMLast Editorial Review: 11/19/2009 10:42:22 AM (Source: MedicineNet Diabetes General)
Source: MedicineNet Diabetes General - November 19, 2009 Category: Endocrinology Source Type: consumer

FTO – Friend or Foe?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Horm Metab ResDOI: 10.1055/s-0029-1241831AbstractFat mass and obesity associated gene () is the most relevant polygene for obesity to date. It has been identified by genome wide association studies concerning body weight regulation. However, its functional relevance for the pathogenesis of obesity remains elusive. Studies in rodents provide data pointing to a central role of through regulation of food intake. In addition, peripheral effects of are also discussed in the literature. This review highlights the possible relevance of for weight regulation and obesity development in central and peripheral tissues with a special ...
Source: Hormone and Metabolic Research - November 19, 2009 Category: Endocrinology Tags: Mini-Review Source Type: journals

The role of endoplasmic reticulum stress in the early stage of diabetic retinopathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to evaluate the role of endoplasmic reticulum (ER) stress in diabetic retinopathy (DR) using in vitro and in vivo models. For the in vivo studies, diabetes was induced in rats, and retinal expression of glucose-regulated protein 78 (GRP78), activating transcription factor 4 (ATF4), C/EBP homologous protein (CHOP), and vascular endothelial growth factor (VEGF) in groups of rats at 1, 3, and 6 months was assessed. For the in vitro studies, human retinal capillary endothelial cells (HRCECs) were cultured in the presence of varying glucose concentrations, and the expression of mRNA and protein for...
Source: Acta Diabetol AND (h... - November 19, 2009 Category: Endocrinology Authors: Li B, Wang HS, Li GG, Zhao MJ, Zhao MH Tags: Acta Diabetol Source Type: journals