Endocrinology 
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This page shows you the most recent publications within this specialty of the MedWorm directory.
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Ethnicity modifies link between HbA1c and FPG in Asian populations
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The use of glycated hemoglobin in place of fasting plasma glucose as an indicator for glycemic status will reclassify Asian individuals’ diabetes status differently depending on their ethnicity, show study findings. (Source: MedWire News - Diabetes)
Source: MedWire News - Diabetes - February 5, 2012 Category: Endocrinology Source Type: news
Attenuating effect of seeds of Adenanthera pavonina aqueous extract in neuropathic pain in streptozotocin-induced diabetic rats: an evidence of neuroprotective effectsEmail this article to a colleague.
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The aim of present study was to investigate the attenuating effects of Adenanthera pavonina L., Leguminosae-Mimosaceae seeds aqueous extract (APSAE), in streptozotocin (STZ)-induced diabetic neuropathy in rats. APSAE (50, 100 and 200 mg/kg per day) was given to diabetic rats for twelve weeks. Cold and hot water tail immersion tests, photoactometer and Rota-rod tests were performed to assess degree of colder, thermal, spontaneous motor activity and motor co-ordination changes respectively at different time intervals i.e., week 0, 4, 8 and 12. Tissue superoxide anion and total calcium levels were determined after twelve week...
Source: Revista Brasileira de Farmacognosia - February 5, 2012 Category: Drugs & Pharmacology Source Type: research
Healing potential of Iranian traditional medicinal plants on burn wounds in alloxan-induced diabetic ratsEmail this article to a colleague.
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Malva sylvestris, Punica granatum, Amygdalus communis, Arnebia euchroma and Scrophularia deserti are important medicinal plants in Iranian traditional medicine (Unani) whose have been used as remedy against edema, burn, and wound and for their carminative, antimicrobial and anti-inflammatory activities. The ethanol extracts of M. sylvestris and P. granatum flowers, A. communis leaves, A. euchroma roots and S. deserti stems were used to evaluate the burn healing activity in alloxan-induced diabetic rats. Burns were induced in Wistar rats divided into nine groups as following; Group-I: normal rats were treated with simple oi...
Source: Revista Brasileira de Farmacognosia - February 5, 2012 Category: Drugs & Pharmacology Source Type: research
Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation.Email this article to a colleague.
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Abstract
OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases. SUMMARY: Initiation of a successful immune response requires a working set of sensors that detect any noxious agent within the cellular microenvironment and molecular platforms that process this signal to trigger an appropriate effector response. Pattern recognition receptors can engage different signalling cascades that lead to proinflammatory gene expression. At the same time, transcription-independent events such as activation of proteases and/or phagocy...
Source: Clinical and Developmental Immunology - February 5, 2012 Category: Allergy & Immunology Authors: Mankan AK, Kubarenko A, Hornung V Tags: Clin Exp Immunol Source Type: research
Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes.Email this article to a colleague.
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Abstract
OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases. SUMMARY: Autoinflammatory syndromes are disorders characterized by the hyperactivation of the innate immune system in the absence of microbial infection or autoantibody production. Some autoinflammatory syndromes are associated with recurrent episodes of fever and systemic inflammation that are caused by dysregulated activation of inflammasomes, molecular platforms responsible for the activation of caspase-1 and the production of interleukin (IL)-1β. In th...
Source: Clinical and Developmental Immunology - February 5, 2012 Category: Allergy & Immunology Authors: Ozkurede VU, Franchi L Tags: Clin Exp Immunol Source Type: research
Immunology in clinic review series; focus on autoinflammatory diseases: update on monogenic autoinflammatory diseases: the role of interleukin (IL)-1 and an emerging role for cytokines beyond IL-1.Email this article to a colleague.
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Abstract
OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases. SUMMARY: The disease-based discovery of the molecular basis for autoinflammatory diseases has led not only to a rapidly growing number of clinically and genetically identifiable disorders, but has unmantled key inflammatory pathways such as the potent role of the alarm cytokine interleukin (IL)-1 in human disease. Following its initial failures in the treatment of sepsis and the moderate success in the treatment of rheumatoid arthritis, IL-1 blocking therap...
Source: Clinical and Developmental Immunology - February 5, 2012 Category: Allergy & Immunology Authors: Goldbach-Mansky R Tags: Clin Exp Immunol Source Type: research
FDA Okays Another Diabetes Combo AgentEmail this article to a colleague.
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WASHINGTON (MedPage Today) -- The FDA has approved an extended-release version of a combination sitagliptin and metformin for adults with type 2 diabetes. (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - February 5, 2012 Category: American Health Source Type: news
Link Between Heart Failure And Thinner Bones And FracturesEmail this article to a colleague.
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Heart failure is associated with a 30 percent increase in major fractures and also identifies a high-risk population that may benefit from increased screening and treatment for osteoporosis, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Osteoporosis and heart failure are common, chronic and costly conditions that share common etiologic factors like older age, post-menopausal status and diabetes... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 5, 2012 Category: Consumer Health News Tags: Heart Disease Source Type: news
Exercise In Low Oxygen Environment May Result In Improved Insulin SensitivityEmail this article to a colleague.
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Intermittent exercise with and without low oxygen concentrations (or hypoxia) can improve insulin sensitivity in type 2 diabetics, however exercise while under hypoxic conditions provides greater improvements in glycemic control than intermittent exercise alone, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Exercise improves glycemic control in patients with type 2 diabetes. Previous studies have focused on continuous aerobic exercise with more recent work assessing resistance exercise... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 5, 2012 Category: Consumer Health News Tags: Diabetes Source Type: news
Probable Mechanism Underlying Resveratrol Activity Revealed By NIH StudyEmail this article to a colleague.
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National Institutes of Health researchers and their colleagues have identified how resveratrol, a naturally occurring chemical found in red wine and other plant products, may confer its health benefits. The authors present evidence that resveratrol does not directly activate sirtuin 1, a protein associated with aging. Rather, the authors found that resveratrol inhibits certain types of proteins known as phosphodiesterases (PDEs), enzymes that help regulate cell energy... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 5, 2012 Category: Consumer Health News Tags: Diabetes Source Type: news
Molecular Biology of Diabetes, Part IIEmail this article to a colleague.
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Insulin Action, Effects on Gene Expression and Regulation, and Glucose TransportThese comprehensive yet concise collections of articles by world experts survey the latest findings on the molecular biology of diabetes and insulin action and synthesize a coherent understanding of the subject. Topics include the etiology of type I and type II diabetes, molecular and cellular aspects of insulin action, and the mechanism of the insulin-stimulated glucose uptake. (Source: Springer Medicine titles)
Source: Springer Medicine titles - February 5, 2012 Category: Databases & Libraries Tags: Endocrinology Source Type: news
FDA approves extended-release tablets for type 2 diabetesEmail this article to a colleague.
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FDA approved sitagliptin and metformin hydrochloride (HCl) extended-release (Janumet XR, Merck)
tablets, a new treatment for type 2 diabetes that combines sitagliptin, which is the active component of Januvia
(sitagliptin), with extended-release metformin. (Source: Drug Topics - Clinical News)
Source: Drug Topics - Clinical News - February 5, 2012 Category: Drugs & Pharmacology Source Type: news
Memory Function - Decaffeinated Coffee May HelpEmail this article to a colleague.
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Drinking decaffeinated coffee may improve brain energy metabolism associated with diabetes type 2, according to a study published in Nutritional Neuroscience and carried out by researchers at Mount Sinai School of Medicine. Brain energy metabolism is a dysfunction with a known risk factor for dementia and other neurodegenerative disorders like Alzheimer's disease... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 4, 2012 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news
Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjectsEmail this article to a colleague.
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Conclusion:
Our study demonstrates that high blood levels of thiamine can be achieved rapidly with oral thiamine hydrochloride. Thiamine is absorbed by both an active and nonsaturable passive process. (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - February 4, 2012 Category: Drugs & Pharmacology Authors: Howard SmithlineMichael DonninoDavid Greenblatt Source Type: research
Ultrasound-Guided Percutaneous Thyroid Nodule Core Biopsy: Clinical Utility in Patients with Prior Nondiagnostic Fine-Needle AspirateEmail this article to a colleague.
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Thyroid , Vol. 0, No. 0. (Source: Thyroid)
Source: Thyroid - February 3, 2012 Category: Endocrinology Tags: article Source Type: research
Diabetes and Its Chronic Complications in the She Ethnic Minority Group of ChinaEmail this article to a colleague.
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Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)
Source: Diabetes Technology - February 3, 2012 Category: Endocrinology Tags: article Source Type: research
Sitagliptin/metformin once-daily combo approved for diabetesEmail this article to a colleague.
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The extended-release combination of sitagliptin and metformin joins saxagliptin/metformin as a once-daily tablet for type 2 diabetes. (Source: theHeart.org)
Source: theHeart.org - February 3, 2012 Category: Cardiology Source Type: news
FDA Approves Once-A-Day Drug for Type 2 DiabetesFDA Approves Once-A-Day Drug for Type 2 DiabetesEmail this article to a colleague.
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Merck's extended-release combination of sitaglipin and metformin has been approved as a once-daily tablet for type 2 diabetes. FDA Approvals (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 3, 2012 Category: Consumer Health News Tags: Diabetes & Endocrinology News Alert Source Type: news
Diet High in Processed Meat Linked to Increased Diabetes Risk in Populations With High Diabetes RateEmail this article to a colleague.
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February 2, 2012 (University of Washington) — Diabetes risk is increased in men and women who eat a diet that is high in processed meats, according to a study published online this week in the American Journal of Clinical Nutrition. Processed meats include hot dogs, lunch meat, sausages and canned meats.
read more (Source: Diabetes News from dLife.com)
Source: Diabetes News from dLife.com - February 3, 2012 Category: Consumer Health News Authors: dlife Source Type: news
Core-Needle Biopsy Is More Useful Than Repeat Fine-Needle Aspiration in Thyroid Nodules Read as Nondiagnostic or Atypia of Undetermined Significance by the Bethesda System for Reporting Thyroid CytopathologyEmail this article to a colleague.
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Thyroid , Vol. 0, No. 0. (Source: Thyroid)
Source: Thyroid - February 3, 2012 Category: Endocrinology Tags: article Source Type: research
Women, Diabetes, and Cardiovascular Risk Women, Diabetes, and Cardiovascular RiskEmail this article to a colleague.
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Is the effect of diabetes on cardiovascular risk greater among women than men? Medscape Diabetes & Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 3, 2012 Category: Consumer Health News Tags: Diabetes & Endocrinology Viewpoint Source Type: news
Preventing Common Pregnancy ProblemEmail this article to a colleague.
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Source: HealthDay -
Related MedlinePlus Page: Diabetes and Pregnancy (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - February 3, 2012 Category: Consumer Health News Source Type: news
Lack of Mutations of the Telomerase RNA Component in Familial Papillary Thyroid Cancer with Short TelomeresEmail this article to a colleague.
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Thyroid , Vol. 0, No. 0. (Source: Thyroid)
Source: Thyroid - February 3, 2012 Category: Endocrinology Tags: article Source Type: research
Evaluation of Candidate Diagnostic MicroRNAs in Thyroid Fine-Needle Aspiration Biopsy SamplesEmail this article to a colleague.
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Thyroid , Vol. 0, No. 0. (Source: Thyroid)
Source: Thyroid - February 3, 2012 Category: Endocrinology Tags: article Source Type: research
Comments Regarding Practice Recommendations of the American Thyroid Association for Radiation Safety in the Treatment of Thyroid Disease with RadioiodineEmail this article to a colleague.
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Thyroid , Vol. 0, No. 0. (Source: Thyroid)
Source: Thyroid - February 3, 2012 Category: Endocrinology Tags: article Source Type: research
Response to Hennessey et al.Email this article to a colleague.
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Thyroid , Vol. 0, No. 0. (Source: Thyroid)
Source: Thyroid - February 3, 2012 Category: Endocrinology Tags: article Source Type: research
Elevated serum homocysteine levels in paediatric patients with primary Raynaud's phenomenonEmail this article to a colleague.
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CONCLUSION: Paediatric patients with RP have increased S-homocysteine levels, suggesting that homocysteine plays an important role in the development of vascular dysfunction, even at an early age (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - February 3, 2012 Category: Rheumatology Source Type: research
Current and relevant concepts in psoriatic arthritisEmail this article to a colleague.
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A artrite psoriásica (APs) é uma doença articular sistêmica e polimórfica de apresentação e curso clínico variáveis, associada a comorbidades importantes como diabetes mellitus, hipertensão arterial e dislipidemia. Para o diagnóstico precoce da doença é necessário alto grau de suspeita clínica, sobretudo quando as manifestações cutâneas são sutis e pouco definidas. Doença erosiva progressiva pode ocorrer em até metade dos pacientes, associada a alterações anatômicas e funcionais em cerca de 20%, de modo que o prognóstico da APs permanece obscuro, especialmente se diagnóstico e tratamento forem tar...
Source: Revista Brasileira de Reumatologia - February 3, 2012 Category: Rheumatology Source Type: research
CysLT1 receptor inhibition in patients with Raynaud's phenomenon: capillaroscopic evidence of the role of leukotrieneEmail this article to a colleague.
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CONCLUSION: The use of montelukast modified the capillary abnormalities observed on nailfold capillaroscopy of patients with Raynaud's phenomenon (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - February 3, 2012 Category: Rheumatology Source Type: research
Merck's combo type 2 diabetes drug gets FDA thumbs upEmail this article to a colleague.
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The FDA has approved Merck's Janumet XR (sitagliptin and metformin hydrochloride extended-release) tablets, a new treatment for type 2 diabetes that combines sitagliptin, which is the active component of Januvia (sitagliptin), with extended-release metformin. (Source: Cardiovascular Business News)
Source: Cardiovascular Business News - February 3, 2012 Category: Cardiology Tags: Latest News Source Type: news
Metabolic Side Effects Such As Obesity And Diabetes Caused By Antipsychotic MedicationsEmail this article to a colleague.
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In 2008, roughly 14.3 million Americans were taking antipsychotics - typically prescribed for bipolar disorder, schizophrenia, or a number of other behavioral disorders - making them among the most prescribed drugs in the U.S. Almost all of these medications are known to cause the metabolic side effects of obesity and diabetes, leaving patients with a difficult choice between improving their mental health and damaging their physical health... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 3, 2012 Category: Consumer Health News Tags: Bipolar Source Type: news
Link Between Insulin Resistance And Brain Health In ElderlyEmail this article to a colleague.
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New research from Uppsala University shows that reduced insulin sensitivity is linked to smaller brain size and deteriorated language skills in seniors. The findings are now published in the scientific journal Diabetes Care. The main hormonal function of insulin is to support the uptake and use of glucose in muscles and fat tissues. However, in an earlier article recently published in Molecular Neurobiology, Christian Benedict from the Department of Neuroscience at Uppsala University has reported that when insulin reaches the brain, it enhances memory function in humans... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 3, 2012 Category: Consumer Health News Tags: Diabetes Source Type: news
Seasonal Changes May Influence The Efficacy Of Vaccination Against DiabetesEmail this article to a colleague.
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The development of a medicine for patients with type 1 diabetes mellitus, based on autoantigen GAD65, received a setback following crucial clinical phase 3 trials that failed to show significant effects. One possible explanation may be seasonal variations in the immune system, claim those responsible for the study that was published in the New England Journal of Medicine (NEJM). At the onset of type 1 diabetes mellitus, the immune system attacks the insulin-producing pancreatic beta-cells... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 3, 2012 Category: Consumer Health News Tags: Diabetes Source Type: news
1 in 2 Stroke Survivors Has High Blood PressureEmail this article to a colleague.
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Title: 1 in 2 Stroke Survivors Has High Blood PressureCategory: Health NewsCreated: 2/3/2012 11:01:00 AMLast Editorial Review: 2/3/2012 (Source: MedicineNet Diabetes General)
Source: MedicineNet Diabetes General - February 3, 2012 Category: Endocrinology Source Type: news
New Heart Failure Risks: Fractures and Memory ProblemsEmail this article to a colleague.
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Title: New Heart Failure Risks: Fractures and Memory ProblemsCategory: Health NewsCreated: 2/3/2012 11:01:00 AMLast Editorial Review: 2/3/2012 (Source: MedicineNet Diabetes General)
Source: MedicineNet Diabetes General - February 3, 2012 Category: Endocrinology Source Type: news
Scientists May Be Closer to Developing 'Red Wine' DrugEmail this article to a colleague.
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Title: Scientists May Be Closer to Developing 'Red Wine' DrugCategory: Health NewsCreated: 2/2/2012 2:06:00 PMLast Editorial Review: 2/3/2012 (Source: MedicineNet Diabetes General)
Source: MedicineNet Diabetes General - February 3, 2012 Category: Endocrinology Source Type: news
Diabetes helped by any exerciseEmail this article to a colleague.
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LONDON, Feb. 3 (UPI) -- Intermittent exercise with and without low oxygen concentrations can improve insulin sensitivity in those with type 2 diabetes, British researchers found. (Source: Health News - UPI.com)
Source: Health News - UPI.com - February 3, 2012 Category: Consumer Health News Source Type: news
US Drug Watchdog Dramatically Intensifies Its Efforts To Insure...Email this article to a colleague.
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The US Drug Watchdog is warning diabetics, who used the diabetes drug called Actos, and then developed bladder cancer, to call them for the names, and contacts of the best possible national caliber...(PRWeb February 01, 2012)Read the full story at http://www.prweb.com/releases/2012/2/prweb9155285.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - February 3, 2012 Category: Pharmaceuticals Source Type: news
Endothelial glycocalyx dysfunction in disease: albuminuria and increased microvascular permeabilityEmail this article to a colleague.
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AbstractAppreciation of the glomerular microcirculation as a specialized microcirculatory bed, rather than as an entirely separate entity, affords important insights into both glomerular and systemic microvascular pathophysiology. In this review we compare regulation of permeability in systemic and glomerular microcirculations, focusing particularly on the role of the endothelial glycocalyx, and consider the implications for disease processes. The luminal surface of vascular endothelium throughout the body is covered with endothelial glycocalyx, comprising surface‐anchored proteoglycans, supplemented with adsorbed solubl...
Source: The Journal of Pathology - February 3, 2012 Category: Pathology Authors: Andrew HJ SalmonSimon C Satchell Tags: Invited Review Source Type: research
Growth Hormone Response Induced by a Respiratory Muscle Endurance Training in Healthy SubjectsEmail this article to a colleague.
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Horm Metab ResDOI: 10.1055/s-0031-1301303To date, the large majority of studies evaluating growth hormone (GH) response to acute physical exercise has been performed involving gross muscle groups. To the best of our knowledge, none has evaluated the effects of a respiratory muscle endurance training (RMET) on hormonal secretions, particularly on GH release, though some respiratory devices have been widely used in athletes to train respiratory muscles and to improve cardiopulmonary function and physical performance. 8 healthy men underwent an incremental progressive RMET protocol of 11 daily sessions, obtained through the u...
Source: Hormone and Metabolic Research - February 3, 2012 Category: Endocrinology Authors: Sartorio, A.Agosti, F.Patrizi, A.Compri, E.Muller, E. E.Cella, S. G.Rigamonti, A. E. Tags: Humans, Clinical Source Type: research
Response to letter to the editor by Gomez-Cabrera et al.Email this article to a colleague.
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(Source: AJP: Endocrinology and Metabolism)
Source: AJP: Endocrinology and Metabolism - February 3, 2012 Category: Endocrinology Authors: Holloszy, J. O., Higashida, K., Kim, S. H., Higuchi, M., Han, D.- H. Tags: Letters to the Editor Source Type: research
Antioxidant supplements in exercise: worse than useless?Email this article to a colleague.
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(Source: AJP: Endocrinology and Metabolism)
Source: AJP: Endocrinology and Metabolism - February 3, 2012 Category: Endocrinology Authors: Gomez-Cabrera, M. C., Ristow, M., Vina, J. Tags: Letters to the Editor Source Type: research
Metabolic characteristics of human subcutaneous abdominal adipose tissueafter overnight fastEmail this article to a colleague.
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We examined within-person variability. Systemic NEFA concentrations, NEFA release, fatty acid re-esterification, and adipose tissue blood flow were all more consistent within than between individuals. This picture of human adipose tissue metabolism in the fasted state should contribute to a greater understanding of adipose tissue physiology and pathophysiology. (Source: AJP: Endocrinology and Metabolism)
Source: AJP: Endocrinology and Metabolism - February 3, 2012 Category: Endocrinology Authors: Frayn, K. N., Humphreys, S. M. Tags: Articles Source Type: research
The anorexigenic cytokine ciliary neurotrophic factor stimulates POMC gene expression via receptors localized in the nucleus of arcuate neuronsEmail this article to a colleague.
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Ciliary neurotrophic factor (CNTF) is a neural cytokine that reduces appetite and body weight when administrated to rodents or humans. We have demonstrated recently that the level of CNTF in the arcuate nucleus (ARC), a key hypothalamic region involved in food intake regulation, is positively correlated with protection against diet-induced obesity. However, the comprehension of the physiological significance of neural CNTF action was still incomplete because CNTF lacks a signal peptide and thus may not be secreted by the classical exocytosis pathways. Knowing that CNTF distribution shares similarities with that of its rece...
Source: AJP: Endocrinology and Metabolism - February 3, 2012 Category: Endocrinology Authors: Couvreur, O., Aubourg, A., Crepin, D., Degrouard, J., Gertler, A., Taouis, M., Vacher, C.-M. Tags: Articles Source Type: research
Multiparity leads to obesity and inflammation in mothers and obesity in male offspringEmail this article to a colleague.
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Multiparity is an independent risk factor for obesity in parous females. In addition to being a health issue for the mother, offspring of multiparous females may also be at risk for obesity later in life. The aim of the current study was to establish a mouse model that mimics the human pathology of multiparity and determine the effects of multiparity-induced obesity (MIO) on offspring in adulthood. C57BL/6 mice were mated and studied when primiparous (1st pregnancy) or multiparous (4th pregnancy). Dams became obese with multiparity, an effect that was independent of the age of the dam. Multiparous dams also had increased m...
Source: AJP: Endocrinology and Metabolism - February 3, 2012 Category: Endocrinology Authors: Rebholz, S. L., Jones, T., Burke, K. T., Jaeschke, A., Tso, P., D'Alessio, D. A., Woollett, L. A. Tags: Articles Source Type: research
Approaches for quantifying energy intake and %calorie restriction during calorie restriction interventions in humans: the multicenter CALERIE studyEmail this article to a colleague.
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Calorie restriction (CR) is a component of most weight loss interventions and a potential strategy to slow aging. Accurate determination of energy intake and %CR is critical when interpreting the results of CR interventions; this is most accurately achieved using the doubly labeled water method to quantify total energy expenditure (TEE). However, the costs and analytical requirements of this method preclude its repeated use in many clinical trials. Our aims were to determine 1) the optimal TEE assessment time points for quantifying average energy intake and %CR during long-term CR interventions and 2) the optimal approach ...
Source: AJP: Endocrinology and Metabolism - February 3, 2012 Category: Endocrinology Authors: Racette, S. B., Das, S. K., Bhapkar, M., Hadley, E. C., Roberts, S. B., Ravussin, E., Pieper, C., DeLany, J. P., Kraus, W. E., Rochon, J., Redman, L. M., The CALERIE Study Group Tags: Articles Source Type: research
Soymorphin-5, a soy-derived {mu}-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPAR{alpha} systems in diabetic KKAy miceEmail this article to a colleague.
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Soymorphin-5 (YPFVV) derived from soybean β-conglycinin β-subunit is a μ-opioid agonist peptide having anxiolytic-like activity. Here, we show that soymorphin-5 improves glucose and lipid metabolism after long-term oral administration to KKAy mice, a type 2 diabetes model animal. Soymorphin-5 inhibited hyperglycemia without an increase in plasma insulin levels in KKAy mice. Soymorphin-5 also decreased plasma and liver triglyceride (TG) levels and liver weight, suggesting that soymorphin-5 improved lipid metabolism. Soymorphin-5 increased plasma adiponectin concentration and liver mRNA expression of AdipoR2, a ...
Source: AJP: Endocrinology and Metabolism - February 3, 2012 Category: Endocrinology Authors: Yamada, Y., Muraki, A., Oie, M., Kanegawa, N., Oda, A., Sawashi, Y., Kaneko, K., Yoshikawa, M., Goto, T., Takahashi, N., Kawada, T., Ohinata, K. Tags: Articles Source Type: research
NADPH oxidase-mediated Rac1 GTP activity is necessary for nongenomic actions of the mineralocorticoid receptor in the CA1 region of the rat hippocampusEmail this article to a colleague.
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In this study, we investigated the relationship between ROS and the nongenomic actions of MR. We examined the nongenomic actions of MR by measuring the slope of the field excitatory postsynaptic potentials and found that ROS induced an additive increase of these potentials, which was accompanied by Rac1 GTP activation and ERK1/2 phosphorylation. An NADPH oxidase inhibitor, apocynin, blocked the nongenomic actions of MRs. A Rac1 inhibitor, NSC23766, was also found to block synaptic enhancement and ERK1/2 phosphorylation induced by NADPH and corticosterone. We concluded that NADPH oxidase activity and Rac1 GTP activity are i...
Source: AJP: Endocrinology and Metabolism - February 3, 2012 Category: Endocrinology Authors: Kawakami-Mori, F., Shimosawa, T., Mu, S., Wang, H., Ogura, S., Yatomi, Y., Fujita, T. Tags: Articles Source Type: research
The hexosamine biosynthetic pathway and O-GlcNAcylation drive the expression of {beta}-catenin and cell proliferationEmail this article to a colleague.
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The short half-life protooncogene β-catenin acquires a remarkable stability in a large subset of cancers, mainly from mutations affecting its proteasomal degradation. In this sense, colorectal cancers (CRC) form a group of pathologies in which early steps of development are characterized by an aberrant expression of β-catenin and an uncontrolled proliferation of epithelial cells. Diet has long been described as an influence in the emergence of CRC, but the molecular events that link metabolic disorders and CRC remain elusive. Part of the explanation may reside in hexosamine biosynthetic pathway (HBP) flux. We fou...
Source: AJP: Endocrinology and Metabolism - February 3, 2012 Category: Endocrinology Authors: Olivier-Van Stichelen, S., Guinez, C., Mir, A.-M., Perez-Cervera, Y., Liu, C., Michalski, J.-C., Lefebvre, T. Tags: Articles Source Type: research
