Endocrinology News 
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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 34.
Positional Cloning of Diabetes Genes
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Several mouse strains are diabetic already at the juvenile age or develop diabetes mellitus during their life. Before these strains become diabetic, they often show several or all features of the metabolic syndrome, which is very similar to the etiology of diabetes in humans. Under the assumption that natural mutations are responsible for the development of diabetes in those mouse strains, they are valuable resources for the identification of diabetes genes and modifiers. Usually, several steps are necessary to detect the causative genes in the genome. These include the initial identification of the genomic regions contrib...
Source: Springer protocols feed by Molecular Medicine - October 1, 2012 Category: Molecular Biology Source Type: news
Beta-Cell AutoimmunityEmail this article to a colleague.
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We describe two protocols that are helpful for the detection of beta-cell autoimmunity in mice. The first protocol describes the detection of insulin-specific autoantibodies using a radio-binding assay. The other is a general CD8+ T cell ELISpot protocol for the detection of peptide-specific responses of CD8+ T cells from secondary lymphoid organs or pancreatic islets.
Source: Springer protocols feed by Molecular Medicine - October 1, 2012 Category: Molecular Biology Source Type: news
Measurement of Glucose Homeostasis In Vivo: Glucose and Insulin Tolerance TestsEmail this article to a colleague.
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The feasibility of investigating glucose tolerance and insulin action and secretion in vivo in mouse models has provided major insights into both type 2 diabetes pathogenesis and the identification of novel strategies to treat this common disorder. When initial studies provide evidence for altered levels of insulin and/or glucose in the animal blood, a number of well-characterized tests can be adopted to estimate glucose homeostasis and insulin action and secretion in vivo. These tests include model assessments, glucose and insulin sensitivity studies, and glucose clamps. None of them can be considered appropriate under al...
Source: Springer protocols feed by Molecular Medicine - October 1, 2012 Category: Molecular Biology Source Type: news
Investigation and Treatment of Type 2 Diabetes in Nonhuman PrimatesEmail this article to a colleague.
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Nonhuman primates provide the ideal animal model for discovering and examining further the mechanisms underlying human type 2 diabetes mellitus. In all aspects studied to date the nonhuman primate has been shown to develop the same disease with the same features that develop in overweight middle-aged humans. This includes the progressive development of the known complications of diabetes, all of which are extraordinarily like those identified in humans. In addition, for the development and evaluation of new therapeutic agents, the translation of findings from nonhuman primates to application in humans has been highly predi...
Source: Springer protocols feed by Molecular Medicine - October 1, 2012 Category: Molecular Biology Source Type: news
The GK Rat: A Prototype for the Study of Non-overweight Type 2 DiabetesEmail this article to a colleague.
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Type 2 diabetes mellitus (T2D) arises when the endocrine pancreas fails to secrete sufficient insulin to cope with the metabolic demand because of β-cell secretory dysfunction and/or decreased β-cell mass. Defining the nature of the pancreatic islet defects present in T2D has been difficult, in part because human islets are inaccessible for direct study. This review is aimed to illustrate to what extent the Goto Kakizaki rat, one of the best characterized animal models of spontaneous T2D, has proved to be a valuable tool offering sufficient commonalities to study this aspect. A comprehensive compendium of the mul...
Source: Springer protocols feed by Molecular Medicine - October 1, 2012 Category: Molecular Biology Source Type: news
Diabetes in Zucker Diabetic Fatty RatEmail this article to a colleague.
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Male Zucker diabetic fatty fa/fa (ZDF) rats develop obesity and insulin resistance at a young age, and then with aging, progressively develop hyperglycemia. This hyperglycemia is associated with impaired pancreatic β-cell function, loss of pancreatic β-cell mass, and decreased responsiveness of liver and extrahepatic tissues to the actions of insulin and glucose. Of particular interest are the insights provided by studies of these animals into the mechanism behind the progressive impairment of carbohydrate metabolism. This feature among others, including the development of obesity- and hyperglycemia-related compl...
Source: Springer protocols feed by Molecular Medicine - October 1, 2012 Category: Molecular Biology Source Type: news
Diet-Induced Diabetes in the Sand Rat (Psammomys obesus)Email this article to a colleague.
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Insulin deficiency is the underlying cause of hyperglycemia in type 2 diabetes. The gerbil Psammomys obesus (P. obesus) is a naturally insulin resistant rodent with tendency to develop diet-induced hyperglycemia associated with obesity. P. obesus does not exhibit hyperglycemia in its natural desert habitat, feeding on low caloric vegetation. However, when fed regular laboratory chow containing higher caloric density, the animals develop moderate obesity and hyperglycemia. Diabetes development and progression is very fast in P. obesus. The animals reach the irreversible hypoinsulinemic stage of the disease, in which a marke...
Source: Springer protocols feed by Molecular Medicine - October 1, 2012 Category: Molecular Biology Source Type: news
The TALLYHO Mouse as a Model of Human Type 2 DiabetesEmail this article to a colleague.
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In conclusion, TH mice encompass many aspects of polygenic human diabetes and are a very useful model for T2D.
Source: Springer protocols feed by Molecular Medicine - October 1, 2012 Category: Molecular Biology Source Type: news
Pathophysiology and Genetics of Obesity and Diabetes in the New Zealand Obese Mouse: A Model of the Human Metabolic SyndromeEmail this article to a colleague.
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The New Zealand Obese (NZO) mouse is one of the most thoroughly investigated polygenic models for the human metabolic syndrome and type 2 diabetes. It presents the main characteristics of the disease complex, including early-onset obesity, insulin resistance, dyslipidemia, and hypertension. As a consequence of this syndrome, a combination of lipotoxicity and glucotoxicity produces beta-cell failure and apoptosis resulting in hypoinsulinemia and diabetic hyperglycemia. With NZO as a breeding partner, several adipogenic and diabetogenic gene variants have been identified by hypothesis-free positional cloning (Tbc1d1, Zfp69) ...
Source: Springer protocols feed by Molecular Medicine - October 1, 2012 Category: Molecular Biology Source Type: news
Diabetes in Mice with Monogenic Obesity: The db/db Mouse and Its Use in the Study of Cardiac ConsequencesEmail this article to a colleague.
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The leptin receptor deficient db/db mouse has served as a rodent model for obesity and type 2 diabetes for more than 40 years. Diabetic features in db/db mice follow an age-dependent progression, with early insulin resistance followed by an insulin secretory defect resulting in profound hyperglycemia. Diabetic db/db mice have been utilized to assess the cardiac consequences of diabetes, specifically evidence for a distinct diabetic cardiomyopathy. The db/db model is characterized by a contractile function deficit in the heart which becomes manifest 8–10 weeks after birth. Metabolic changes include an increased relian...
Source: Springer protocols feed by Molecular Medicine - October 1, 2012 Category: Molecular Biology Source Type: news
Experimentally Induced Rodent Models of Type 2 DiabetesEmail this article to a colleague.
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Diabetes is one of the major global public health problems and is gradually getting worse particularly in developing nations where 95% of patients are suffering from type 2 diabetes (T2D). Animal models in diabetes research are very common where rodents are the best choice of use due to being smaller in size, easy to handle, omnivorous in nature, and non-wild tranquil behavior. Normally rodent models are classified into two major classes namely: (1) genetic or spontaneously induced models and (2) non-genetic or experimentally induced models. Non-genetic models are more popular compared to genetic models due to lower cost, ...
Source: Springer protocols feed by Molecular Medicine - October 1, 2012 Category: Molecular Biology Source Type: news
The BB Rat as a Model of Human Type 1 DiabetesEmail this article to a colleague.
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The BB rat is an important rodent model of human type 1 diabetes (T1D) and has been used to study mechanisms of diabetes pathogenesis as well as to investigate potential intervention therapies for clinical trials. The Diabetes-Prone BB (BBDP) rat spontaneously develops autoimmune T1D between 50 and 90 days of age. The Diabetes-Resistant BB (BBDR) rat has similar diabetes-susceptible genes as the BBDP, but does not become diabetic in viral antibody-free conditions. However, the BBDR rat can be induced to develop T1D in response to certain treatments such as regulatory T cell (Treg) depletion, toll-like receptor ligation, or...
Source: Springer protocols feed by Molecular Medicine - October 1, 2012 Category: Molecular Biology Source Type: news
Assessment of Diabetic Nephropathy in the Akita MouseEmail this article to a colleague.
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Akita mice have type 1 diabetes mellitus caused by a spontaneous point mutation in the Ins2 gene which leads to misfolding of insulin, resulting in pancreatic β-cell failure. Akita mice develop pronounced and sustained hyperglycemia, high levels of albuminuria, and consistent histopathological changes, suggesting that these mice may be suitable as an experimental platform for modeling diabetic nephropathy. One key feature of diabetic kidney disease in Akita mice is that the severity of renal injury is significantly influenced by genetic background. In this chapter, we describe the Akita model and present some of the e...
Source: Springer protocols feed by Molecular Medicine - October 1, 2012 Category: Molecular Biology Source Type: news
The Non-Obese Diabetic (NOD) Mouse as a Model of Human Type 1 DiabetesEmail this article to a colleague.
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We describe how genetic approaches to identifying causative gene variants can be adapted to identify novel therapeutic agents for reversing new-onset T1D.
Source: Springer protocols feed by Molecular Medicine - October 1, 2012 Category: Molecular Biology Source Type: news
Prompt laser adds naught to ranibizumab in diabetic macular edemaEmail this article to a colleague.
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NEW YORK (Reuters Health) - In patients with diabetic macular edema, laser treatment at the start of
intravitreal ranibizumab therapy shows no benefit, according to a new paper.
Source: Modern Medicine - October 1, 2012 Category: Journals (General) Source Type: news
Mobile health apps hold big potential for diabetes managementEmail this article to a colleague.
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Mobile health applications can help socially disadvantaged patients overcome obstacles that prevent
them from effectively managing diabetes, a recent study concluded.
Source: Modern Medicine - October 1, 2012 Category: Journals (General) Source Type: news
Insulin degludec (Tresiba®) approved in JapanEmail this article to a colleague.
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Source: BioSpace
Area: News
According to a company press release, the Japanese Ministry of Health, Labour and Welfare has approved the once daily basal insulin degludec (Tresiba®) for the treatment of diabetes. The approval was supported by data from a global clinical trial programme, including studies showing comparable reductions in HbA1c to insulin glargine, with a lower risk of nocturnal hypoglycaemia.
Tresiba® was submitted for regulatory approval to the European Medicines Agency and the US FDA in September 2011.
Source: NeLM - News - October 1, 2012 Category: Drugs & Pharmacology Source Type: news
JCI early table of contents for October 1, 2012Email this article to a colleague.
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(Journal of Clinical Investigation) This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, October 1, 2012, in the JCI: Sphingolipid metabolism contributes to diabetes-associated heart disease; Altered triglyceride metabolism in mice causes non-alcoholic fatty liver disease; Researchers identify inflammatory mediators in pancreatic cancer; Putting a "HEX" on muscle regeneration; and many more.
Source: EurekAlert! - Cancer - October 1, 2012 Category: Cancer & Oncology Source Type: news
Scottish GPs improve their quality scoresEmail this article to a colleague.
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Average score rose from 976.3 to 980.9 out of 1,000 in 2011/12Related items from OnMedicaShake-up to QOF puts focus on outcomesMore GP practices achieving QOF maximum, latest figures showQOF needs four new child health measuresNew QOF indicators focus on arthritis and diabetesPatients in Scotland gain right to be treated within 12 weeks
Source: OnMedica Latest News - October 1, 2012 Category: UK Health Source Type: news
JDRF to showcase spectrum of prominent research at European Diabetes ConferenceEmail this article to a colleague.
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(JDRF) JDRF, the worlds leader in setting the agenda of type 1 diabetes (T1D) research, is preparing to join researchers from around the globe this week at the annual meeting of the European Association for the Study of Diabetes (EASD), being held in Berlin from October 1 through October 5.
Source: EurekAlert! - Medicine and Health - October 1, 2012 Category: Global & Universal Source Type: news
Moderate alcohol consumption may increase risk of atrial fibrillation in people with heart diseaseEmail this article to a colleague.
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(Canadian Medical Association Journal) Moderate alcohol consumption increases the risk of atrial fibrillation in older people with heart disease or advanced diabetes, found a study in the Canadian Medical Association Journal.
Source: EurekAlert! - Social and Behavioral Science - October 1, 2012 Category: Global & Universal Source Type: news
Zinc deficiency mechanism linked to aging, multiple diseasesEmail this article to a colleague.
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(Oregon State University) A new study has outlined for the first time a biological mechanism by which zinc deficiency can develop with age, leading to a decline of the immune system and increased inflammation associated with many health problems, including cancer, heart disease, autoimmune disease and diabetes.
Source: EurekAlert! - Social and Behavioral Science - October 1, 2012 Category: Global & Universal Source Type: news
Low birth weight may increase risk for cardiovascular disease, kidney disease and diabetesEmail this article to a colleague.
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(Federation of American Societies for Experimental Biology) Being born underweight may have consequences other than the known short-term effects according to research published in the October 2012 issue of The FASEB Journal Low birth weight rats have an increased long-term risk for cardiovascular and kidney disease, and diabetes. Also, older females are at higher risk of developing high blood pressure before and during pregnancy, which may restrict growth in the womb, causing offspring to born at a low birth weight.
Source: EurekAlert! - Medicine and Health - October 1, 2012 Category: Global & Universal Source Type: news
Reubin Andres, an Advocate of Weight Gain, Dies at 89Email this article to a colleague.
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Dr. Andres, noted in the study of diabetes, gained his widest attention for challenging the conventional standards of late-life weight maintenance.
Source: NYT Health - September 30, 2012 Category: Consumer Health News Authors: By LESLIE KAUFMAN Tags: Obesity National Institute on Aging Deaths (Obituaries) Andres, Reubin Longevity MetLife Inc MET NYSE Diabetes Diet and Nutrition Source Type: news
What Are Causes of Sudden Cardiac Death?Email this article to a colleague.
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Discussion
Sudden death of a young person is a tragic event for the family and community no matter the cause. Healthy-appearing, young persons who suddenly die while engaging in athletic pursuits strikes as particularly catastrophic. Screening potential student athletes for possible cardiac problems is recommended using a variety of history and physical examination criteria. See To Learn More below. There are strong opinions that these guidelines do not go far enough and more modalities such as electrocardiograms and/or echocardiograms should be used.
Evaluation of surviving family members where a documented sudden cardiac...
Source: PediatricEducation.org - September 30, 2012 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news
Fat location predicts diabetesEmail this article to a colleague.
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DALLAS, Sept. 30 (UPI) -- People with belly fat have an increased risk for the development of type 2 diabetes compared to those with fat all over the body, U.S. researchers say.
Source: Health News - UPI.com - September 30, 2012 Category: Consumer Health News Source Type: news
Harvesting experiential expertise to support safe driving for people with diabetes mellitus: a qualitative study evaluated by peers in a survey - Burda MH, van der Horst F, van den Akker M, Stork AD, Mesters I, Bours S, Ploeg M, Winkens B, Knottnerus JA.Email this article to a colleague.
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Background: Hypoglycemia is a frequent phenomenon in people being treated for diabetes mellitus, which can acutely disrupt driving performance. For the benefit of personal and public traffic safety, we decided to identify successful diabetes-related (SDR) ...
Source: SafetyLit: All (Unduplicated) - September 30, 2012 Category: Global & Universal Tags: Sensing and Response Issues Source Type: news
Discovery Of Leptin In Fruit Flies Has Implications For Obesity And Diabetes ResearchEmail this article to a colleague.
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Researchers have discovered in fruit flies a key metabolic hormone thought to be the exclusive property of vertebrates. The hormone, leptin, is a nutrient sensor, regulating energy intake and output and ultimately controlling appetite. As such, it is of keen interest to researchers investigating obesity and diabetes on the molecular level. But until now, complex mammals such as mice have been the only models for investigating the mechanisms of this critical hormone. These new findings suggest that fruit flies can provide significant insights into the molecular underpinnings of fat sensing...
Source: Health News from Medical News Today - September 30, 2012 Category: Consumer Health News Tags: Obesity / Weight Loss / Fitness Source Type: news
Study Links Benzodiazepines to Higher Rates of DementiaEmail this article to a colleague.
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A study published this week in the British Medical Journal reported that use of benzodiazepines increased the risk of developing dementia. Researchers followed over 1000 participants who had been free of dementia for three years prior to the start of the study. For 15 years, they tracked medication usage and cognitive status. They also took into account other factors such as age, gender, diabetes, high blood pressure, education level and more.
The results? A history of any use of benzodiazepines was connected with a 50% higher chance of developing dementia. The most common type of dementia is Alzheimer's, but other type...
Source: About Alzheimers Disease - September 30, 2012 Category: Consumer Health Advice Source Type: news
Lack of sleep leads to insulin resistance in teensEmail this article to a colleague.
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A new study suggests that increasing the amount of sleep that teenagers get could improve their insulin resistance and prevent the future onset of diabetes.
Source: ScienceDaily Headlines - September 29, 2012 Category: Science Source Type: news
Fatal metformin intoxication with markedly elevated blood and liver concentrations - Cantrell FL, Nelson CL, Gary RD, McIntyre IM.Email this article to a colleague.
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Metformin (Glucophage) is a medication used to treat Type 2 diabetes. The highest postmortem metformin concentrations are recorded utilizing a sensitive and specific analytical procedure. The peripheral blood metformin concentration was 240 mg/L, the liver...
Source: SafetyLit: All (Unduplicated) - September 29, 2012 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
Leptin Implicated In Hearing And Vision LossEmail this article to a colleague.
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Leptin - commonly dubbed the "fat hormone" - does more than tell the brain when to eat. A new study by researchers at The University of Akron and Northeast Ohio Medical University (NEOMED) shows that leptin may play a role in hearing and vision loss. This discovery, made in zebrafish treated to produce low leptin, could ultimately help doctors better understand sensory loss in humans...
Source: Health News from Medical News Today - September 29, 2012 Category: Consumer Health News Tags: Endocrinology Source Type: news
Lack of sleep leads to insulin resistance in teensEmail this article to a colleague.
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(American Academy of Sleep Medicine) A new study suggests that increasing the amount of sleep that teenagers get could improve their insulin resistance and prevent the future onset of diabetes.
Source: EurekAlert! - Medicine and Health - September 29, 2012 Category: Global & Universal Source Type: news
Lab Notes: Mice Grow New Skin, with No ScarsEmail this article to a colleague.
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(MedPage Today) -- An African mouse that can regrow much of its skin without scarring could point the way to new tissue regeneration strategies. Also this week: a potential virus-based treatment for acne.
Source: MedPage Today Endocrinology - September 28, 2012 Category: Endocrinology Source Type: news
PodMed: A Medical News Roundup From Johns Hopkins (with audio)Email this article to a colleague.
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(MedPage Today) -- This week's topics include the dangers of sugar-sweetened beverages, exercise, diabetes and mortality, steroids and tonsillectomy, and total knee replacements.
Source: MedPage Today Cardiovascular - September 28, 2012 Category: Cardiology Source Type: news
Hypertension and Glucotoxicity in a Patient with Newly Diagnosed Type 2 Diabetes: Treatment RecommendationsEmail this article to a colleague.
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Hypertension is very common in people with diabetes; in this patient’s case, it may have been present for 5 to 10 years before the hyperglycemia appeared.
Source: Consultant Live - September 28, 2012 Category: Primary Care Source Type: news
EHRs lead to more testing, positive outcomes for diabetes, high cholesterolEmail this article to a colleague.
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EHR implementation at Kaiser Permanente Northern California facilities led to improved drug treatment intensification, monitoring and physiologic control among patients with diabetes and high cholesterol, according to research published Oct. 1 in the Annals of Internal Medicine.
Source: CMIO.net: The News Weekly for Health IT Executives - September 28, 2012 Category: Information Technology Tags: Latest News Source Type: news
Device Rules in Crosshairs at EASD Meeting (with audio)Email this article to a colleague.
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BERLIN (MedPage Today) -- A new European Union proposal to tighten regulation of medical devices is expected to generate heated debate, Viktor Joergens, MD, executive director of the European Association for the Study of Diabetes, said in this exclusive interview in advance of the group's annual meeting.
Source: MedPage Today Primary Care - September 28, 2012 Category: Primary Care Source Type: news
Licorice Abuse: Time to Send a Warning MessageLicorice Abuse: Time to Send a Warning MessageEmail this article to a colleague.
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Licorice… Delicious or dangerous? Therapeutic Advances in Endocrinology and Metabolism
Source: Medscape Nurses Headlines - September 28, 2012 Category: Nursing Tags: Family Medicine/Primary Care Journal Article Source Type: news
Current Guidelines for the Management of Thyroid NodulesCurrent Guidelines for the Management of Thyroid NodulesEmail this article to a colleague.
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When should a thyroid nodule be biopsied? Endocrine Practice
Source: Medscape Today Headlines - September 28, 2012 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
Scientists Find Molecular Link to Obesity/Insulin Resistance in MiceEmail this article to a colleague.
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September 25, 2012 (Newswise) — Flipping a newly discovered molecular switch in white fat cells enabled mice to eat a high-calorie diet without becoming obese or developing the inflammation that causes insulin resistance, report scientists from Dana-Farber Cancer Institute.
read more
Source: Diabetes News from dLife.com - September 28, 2012 Category: Consumer Health News Authors: dlife Source Type: news
New Study Shows Family Health History Does Not Impact Consumer Knowledge of High-Sodium Diet RisksEmail this article to a colleague.
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read more
Source: Diabetes News from dLife.com - September 28, 2012 Category: Consumer Health News Authors: dlife Source Type: news
Diabetes Quiz: Hypertension and Glucotoxicity in Newly Diagnosed Type 2 Diabetes—How Would You Treat?Email this article to a colleague.
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In addition to lifestyle changes how would you treat this patient?
Source: Consultant Live - September 28, 2012 Category: Primary Care Source Type: news
Recent Advances in Incretin-Based TherapiesRecent Advances in Incretin-Based TherapiesEmail this article to a colleague.
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How does liraglutide compare with linagliptin? Clinical Endocrinology
Source: Medscape Today Headlines - September 28, 2012 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
Child diabetes care 'lags behind adult'Email this article to a colleague.
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Diabetes care is improving but many children are still not receiving the right standard of treatment, according to a new study.
Source: Nursing Times Breaking News - September 28, 2012 Category: Nursing Source Type: news
Widely used sleeping pill 'increases dementia' riskEmail this article to a colleague.
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Conclusion
This research demonstrates an association between new benzodiazepine use among elderly adults and the risk of developing dementia. The study has several strengths, including its long follow-up period and valid assessment of dementia development. Some limitations are that:
Despite the relatively large sample size, the actual number of new users of benzodiazepines after the third year of study was quite small (95), therefore limiting the ability to detect reliable differences in dementia risk among users and non-users (the smaller a sample size the more likely it is that any detected effects are the results of ...
Source: NHS News Feed - September 28, 2012 Category: Consumer Health News Tags: Medication Source Type: news
Potential Breakthrough In Treating Type 2 DiabetesEmail this article to a colleague.
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By blocking VEGF-B, a signaling protein, fat does not accumulate in muscles and the heart, and the cells within those tissues can respond properly to insulin again, researchers from the Karolinska Institute, Sweden, the Ludwig Institute for Cancer Research, based in New York, and the Australian biopharmaceutical company CSL Limited reported in the journal Nature...
Source: Health News from Medical News Today - September 28, 2012 Category: Consumer Health News Tags: Diabetes Source Type: news
Do Chemicals Cause Diabetes?Email this article to a colleague.
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Is it true that certain widely used chemicals can cause type 2 diabetes? If so, which ones are to blame, and what can we do to avoid them?
Source: Dr. Weil Q and A - September 28, 2012 Category: Consumer Health Advice Source Type: news
