GastroenterologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory.

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Prospective comparison of endoscopic ultrasound-guided fine-needle aspiration and surgical histology in upper gastrointestinal submucosal tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
EndoscopyDOI: 10.1055/s-0029-1244006 To assess the accuracy of ultrasound-guided fine-needle aspiration biopsy in the differential diagnosis of gastrointestinal stroma cell tumors (GIST) from other submucosal tumors, using both cytology and histology.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Endoscopy)
Source: Endoscopy - March 20, 2010 Category: Gastroenterology Tags: Original article Source Type: journals

Accuracy of endoscopic ultrasound in preoperative staging of esophageal cancer: results from a referral center for early esophageal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
EndoscopyDOI: 10.1055/s-0029-1244022 Endoscopic ultrasound (EUS) has been regarded as the most accurate staging tool in esophageal cancer. Staging results have a strong impact on the decision as to whether a patient should undergo endoscopic treatment, surgery alone, or neoadjuvant therapy. This retrospective study was conducted to analyze the accuracy of esophageal cancer staging using EUS.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Endoscopy)
Source: Endoscopy - March 20, 2010 Category: Gastroenterology Tags: Original article Source Type: journals

Can early precut implementation reduce endoscopic retrograde cholangiopancreatography-related complication risk? Meta-analysis of randomized controlled trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
EndoscopyDOI: 10.1055/s-0029-1243992 Precut papillotomy is considered a risk factor for endoscopic retrograde cholangiopancreatography (ERCP)-related complications; however whether the complication risk is due to precut itself or to the prior prolonged attempts is still debated; therefore, early precut implementation has been suggested to reduce the complication rate. We conducted a meta-analysis of randomized controlled trials (RCTs) comparing cannulation and complication rates of early precut implementation with persistent attempts by the standard approach.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected...
Source: Endoscopy - March 20, 2010 Category: Gastroenterology Tags: Original article Source Type: journals

Body mass index and risk of liver cirrhosis in middle aged UK women: prospective studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: NHS Evidence - Gastroenterology and liver diseases - News)
Source: NHS Evidence - Gastroenterology and liver diseases - News - March 20, 2010 Category: Gastroenterology Source Type: organizations

Current role of hyperthermic intraperitoneal chemotherapy in the treatment of peritoneal carcinomatosis from colorectal cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Peritoneal carcinomatosis is one of the most common routes of dissemination of colorectal cancer (CRC). It is encountered in 7% of patients at primary surgery, while it develops in about 4% to 19% of patients after curative surgery and in up to 44% of patients with recurrent CRC. Peritoneal involvement from colorectal malignancies has been considered traditionally as a manifestation of terminal disease, due to limited response to conventional surgical and chemotherapeutic treatments. In the past few years the introduction of cytoreductive surgery combined with hyperthermic intraperitoneal chemoperfusion has shown promi...
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Rampone B, Schiavone B, Martino A, Confuorto G Tags: World J Gastroenterol Source Type: journals

Alcohol and liver, 2010.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Liver is known as an organ that is primarily affected by alcohol. Alcoholic liver disease (ALD) is the cause of an increased morbidity and mortality worldwide. Progression of ALD is driven by "second hits". These second hits include the complex of nutritional, pharmacological, genetic and viral factors, which aggravate liver pathology. However, in addition to liver failure, ethanol causes damage to other organs and systems. These extrahepatic manifestations are regulated via the similar hepatitis mechanisms. In the Topic Highlight series, we provide an update of current knowledge in the field of ALD. PMID: 20238395...
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Osna NA Tags: World J Gastroenterol Source Type: journals

Alcohol, inflammation, and gut-liver-brain interactions in tissue damage and disease development.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic inflammation is often associated with alcohol-related medical conditions. The key inducer of such inflammation, and also the best understood, is gut microflora-derived lipopolysaccharide (LPS). Alcohol can significantly increase the translocation of LPS from the gut. In healthy individuals, the adverse effects of LPS are kept in check by the actions and interactions of multiple organs. The liver plays a central role in detoxifying LPS and producing a balanced cytokine milieu. The central nervous system contributes to anti-inflammatory regulation through neuroimmunoendocrine actions. Chronic alcohol use impairs ...
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Wang HJ, Zakhari S, Jung MK Tags: World J Gastroenterol Source Type: journals

Alcoholic pancreatitis: Lessons from the liver.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The association between alcohol consumption and pancreatitis has been recognized for over 100 years. Despite the fact that this association is well recognized, the mechanisms by which alcohol abuse leads to pancreatic tissue damage are not entirely clear. Alcohol abuse is the major factor associated with pancreatitis in the Western world. Interestingly, although most cases of chronic pancreatitis and many cases of acute pancreatitis are associated with alcohol abuse, only a small percentage of individuals who abuse alcohol develop this disease. This situation is reminiscent of the association between alcohol abuse and ...
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Clemens DL, Mahan KJ Tags: World J Gastroenterol Source Type: journals

Alcoholic liver disease and the gut-liver axis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alcoholic liver disease (ALD) is one of the leading causes of liver diseases and liver-related death worldwide. Of the many factors that contribute to the pathogenesis of ALD, gut-derived lipopolysaccharide (LPS) plays a central role in induction of steatosis, inflammation, and fibrosis in the liver. In this review, we discuss the mechanisms by which alcohol contributes to increased gut permeability, the activation of Kupffer cells, and the inflammatory cascade by LPS. The role of the Toll-like receptor 4 (TLR4) complex in LPS recognition and the importance of the TLR4-induced signaling pathways are evaluated in ALD. ...
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Szabo G, Bala S Tags: World J Gastroenterol Source Type: journals

Anti-inflammatory pathways and alcoholic liver disease: Role of an adiponectin/interleukin-10/heme oxygenase-1 pathway.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The development of alcoholic liver disease (ALD) is a complex process involving both the parenchymal and non-parenchymal cells in the liver. Enhanced inflammation in the liver during ethanol exposure is an important contributor to injury. Kupffer cells, the resident macrophages in liver, are particularly critical to the onset of ethanol-induced liver injury. Chronic ethanol exposure sensitizes Kupffer cells to activation by lipopolysaccharide via Toll-like receptor 4. This sensitization enhances production of inflammatory mediators, such as tumor necrosis factor-alpha and reactive oxygen species, that contribute to hep...
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Mandal P, Pritchard MT, Nagy LE Tags: World J Gastroenterol Source Type: journals

Impact of alcohol on hepatitis C virus replication and interferon signaling.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatitis C virus (HCV) is one of the main etiological factors responsible for liver disease worldwide. It has been estimated that there are over 170 million people infected with HCV worldwide. Of these infected individuals, approximately 75% will go on to develop a life long necroinflammatory liver disease, which over decades, can result in serious complications, such as cirrhosis and hepatocellular carcinoma. Currently there is no effective vaccine and whilst antiviral therapies have been improved, they are still only effective in approximately 50% of individuals. HCV infection stands as a major cause of global morbi...
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: McCartney EM, Beard MR Tags: World J Gastroenterol Source Type: journals

Alcohol, nutrition and liver cancer: Role of Toll-like receptor signaling.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the evidence that ties the development of hepatocellular carcinoma (HCC) to the natural immune pro-inflammatory response to chronic liver disease, with a focus on the role of Toll-like receptor (TLR) signaling as the mechanism of liver stem cell/progenitor transformation to HCC. Two exemplary models of this phenomenon are reviewed in detail. One model applies chronic ethanol/lipopolysaccharide feeding to the activated TLR4 signaling pathway. The other applies chronic feeding of a carcinogenic drug, in which TLR2 and 4 signaling pathways are activated. In the drug-induced model, two major methyl donors,...
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: French SW, Oliva J, French BA, Li J, Bardag-Gorce F Tags: World J Gastroenterol Source Type: journals

Effects of ethanol on the proteasome interacting proteins.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Proteasome dysfunction has been repeatedly reported in alcoholic liver disease. Ethanol metabolism end-products affect the structure of the proteasome, and, therefore, change the proteasome interaction with its regulatory complexes 19S and PA28, as well as its interacting proteins. Chronic ethanol feeding alters the ubiquitin-proteasome activity by altering the interaction between the 19S and the 20S proteasome interaction. The degradation of oxidized and damaged proteins is thus decreased and leads to accumulation of insoluble protein aggregates, such as Mallory-Denk bodies. Ethanol also affects the immunoproteasome f...
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Bardag-Gorce F Tags: World J Gastroenterol Source Type: journals

Alcohol-induced alterations of the hepatocyte cytoskeleton.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The hepatocyte cytoskeleton consists of three filamentous networks: microtubules, actin microfilaments and keratin intermediate filaments. Because of the abundance of the proteins that comprise each system and the central role each network plays in a variety of cellular processes, the three filament systems have been the focus of a host of studies aimed at understanding the progression of alcohol-induced liver injury. In this review, we will briefly discuss the hepatic organization of each cytoskeletal network and highlight some components of each system. We will also describe what is known about ethanol-induced change...
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Shepard BD, Tuma PL Tags: World J Gastroenterol Source Type: journals

Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
S-adenosyl-L-methionine (SAM) acts as a methyl donor for methylation reactions and participates in the synthesis of glutathione. SAM is also a key metabolite that regulates hepatocyte growth, differentiation and death. Hepatic SAM levels are decreased in animal models of alcohol liver injury and in patients with alcohol liver disease or viral cirrhosis. This review describes the protection by SAM against alcohol and cytochrome P450 2E1-dependent cytotoxicity both in vitro and in vivo and evaluates mechanisms for this protection. PMID: 20238404 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Cederbaum AI Tags: World J Gastroenterol Source Type: journals

Alcoholic liver injury: Influence of gender and hormones.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article discusses several subjects pertinent to a consideration of the role of gender and hormones in alcoholic liver injury (ALI). Beginning with an overview of factors involved in the pathogenesis of ALI, we review changes in sex hormone metabolism resulting from alcohol ingestion, summarize research that points to estrogen as a cofactor in ALI, consider evidence that gut injury is linked to liver injury in the setting of alcohol, and briefly review the limited evidence regarding sex hormones and gut barrier function. In both women and female animals, most studies reveal a propensity toward greater alcohol-induced l...
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Eagon PK Tags: World J Gastroenterol Source Type: journals

Time-series gene expression profiles in AGS cells stimulated with Helicobacter pylori.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Early infection may trigger some important pathways and may impact the outcome of the infection. PMID: 20238406 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: You YH, Song YY, Meng FL, He LH, Zhang MJ, Yan XM, Zhang JZ Tags: World J Gastroenterol Source Type: journals

Combined MELD and blood lipid level in evaluating the prognosis of decompensated cirrhosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: MELD >/= 18 and TC </= 2.8 mmol/L are two important indexes to predict the prognosis of patients with decompensated cirrhosis. Their combination can effectively predict the long-term prognosis of patients with decompensated cirrhosis. PMID: 20238407 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Jiang M, Liu F, Xiong WJ, Zhong L, Xu W, Xu F, Liu YB Tags: World J Gastroenterol Source Type: journals

Effects on the pouch of different digestive tract reconstruction modes assessed by radionuclide scintigraphy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Dual Braun type esophagojejunal anastomosis is the most useful of the three procedures for improving food accommodation in patients with a pouch and can retard evacuation of solid food from the reconstructed pouch. PMID: 20238408 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Li DS, Xu HM, Han CQ, Li YM Tags: World J Gastroenterol Source Type: journals

Role of BMP3 in progression of gastric carcinoma in Chinese people.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Promotor region methylation of the BMP3 gene may cause gastric carcinoma in Chinese people. PMID: 20238409 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Chen XR, Wang JW, Li X, Zhang H, Ye ZY Tags: World J Gastroenterol Source Type: journals

Interferon-alpha induced severe thrombocytopenia: A case report and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of severe thrombocytopenia following pegylated interferon-alpha 2a (Peg-IFN-alpha 2a) treatment of hepatitis C virus infection and summarize the clinical characteristics of 16 cases of IFN-alpha induced severe thrombocytopenia and its immune-mediated mechanism. Discontinuation of IFN-alpha and early administration of immunosuppressants are the effective therapy for IFN-alpha induced severe thrombocytopenia. PMID: 20238410 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Li L, Han DK, Lu J Tags: World J Gastroenterol Source Type: journals

A case of occult insulinoma localized by pancreatic dynamic enhanced spiral CT.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Insulinomas are the most common category of pancreatic endocrine tumors, with an annual incidence of 1-4 cases per million people. Most are intrapancreatic, benign and solitary. Therefore, they have an excellent prognosis after surgical resection. However, the localization diagnosis of insulinomas still poses a challenge to surgeons and radiologists. In this case, the tumor was occult and could not be found by either abdominal enhanced spiral computed tomography (CT) or ultrasonography. Therefore, we tried a new method of CT scanning and localized the tumor. PMID: 20238411 [PubMed - in process] (Source: World Journ...
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Bao ZK, Huang XY, Zhao JG, Zheng Q, Wang XF, Wang HC Tags: World J Gastroenterol Source Type: journals

Resection of a giant hepatocellular carcinoma weighing over ten kilograms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors report a giant hepatocellular carcinoma (HCC) with a diameter over 30 cm and weight over 10 kg that was resected completely. A 62-year-old man was admitted because of continuous abdominal uplift. A computed tomography scan demonstrated that the entire abdomen was filled with a giant tumor containing both cystic and solid components with a size of 29 cm x 22 cm. The huge tumor was successfully resected without any complication, such as massive hemorrhage or visceral injuries. The size and weight of the tumor were 35 cm x 30 cm x 15 cm and 10 050 g, respectively. Pathological examination showed that the tumor...
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Ba MC, Cui SZ, Lin SQ, Tang YQ, Wu YB, Zhang XL Tags: World J Gastroenterol Source Type: journals

Liver transplantation for polycystic liver and massive hepatomegaly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Liver tumor and other benign liver diseases such as polycystic liver disease can cause massive hepatomegaly and may represent an indication for liver transplantation (LT) in some instances. In this setting, LT can be extremely difficult and challenging due to its decreased mobility and access to vascular supply. Benefit from either a right or a left partial liver resection during the transplant procedure has been advocated to safely accomplish the hepatectomy of the native liver. Although we believe that partial hepatectomy adds some risk to intra-operative bleeding, we alternatively advise a different approach. We hav...
Source: World Journal of Gastroenterology : WJG - March 20, 2010 Category: Gastroenterology Authors: Gruttadauria S, di Francesco F, Gridelli B Tags: World J Gastroenterol Source Type: journals

Augmentation of the ascending component of the peristaltic reflex and substance P release by glial cell line-derived neurotrophic factorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions & Inferences The results suggest that endogenous GDNF is released during the ascending contraction component of the peristaltic reflex where it acts as a neuromodulator to augment SP release from motor neurons thereby augmenting contraction of circular muscle orad to the site of stimulation. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - March 20, 2010 Category: Gastroenterology Authors: j. r. grider, r. o. heuckeroth, j. f. kuemmerle, k. s. murthy Source Type: journals

Ameliorating effects and mechanisms of electroacupuncture on gastric dysrhythmia, delayed emptying, and impaired accommodation in diabetic ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to investigate the effects and mechanisms of electroacupuncture (EA) on gastric accommodation, gastric dysrhythmia, and gastric emptying (GE) in streptozotocin (STZ)-induced diabetic rats. Five experiments were performed in five groups of STZ-induced diabetic rats to study the effects of EA at ST-36 (Zusanli) on gastric slow-wave dysrhythmia, delayed GE and intestinal transit, impaired gastric accommodation, and the mechanisms of EA involving the autonomic and opioidergic pathways. We found the following: 1) EA improved gastric dysrhythmia in the diabetic rats. The normal percentage of slow waves ...
Source: AJP: Gastrointestinal and Liver Physiology - March 19, 2010 Category: Gastroenterology Authors: Yin, J., Chen, J., Chen, J. D. Z. Tags: NEUROREGULATION AND MOTILITY Source Type: journals

Insulin-like growth factors are more effective than progastrin in reversing proapoptotic effects of curcumin: critical role of p38MAPKEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Progastrin and insulin-like growth factors (IGFs) stimulate hyperproliferation of intestinal epithelial cells (IECs) via endocrine/paracrine routes; hyperproliferation is a known risk factor for colon carcinogenesis. In the present study, inhibitory potency of curcumin in the presence or absence of progastrin and/or IGF-II was examined. Progastrin and IGF-II significantly increased proliferation of an immortalized IEC cell line, IEC-18, whereas curcumin decreased the proliferation in a dose-dependent manner. IGF-II was significantly more effective than progastrin in reversing antiproliferative effects of curcumin and rever...
Source: AJP: Gastrointestinal and Liver Physiology - March 19, 2010 Category: Gastroenterology Authors: Singh, P., Sarkar, S., Umar, S., Rengifo-Cam, W., Singh, A. P., Wood, T. G. Tags: MUCOSAL BIOLOGY Source Type: journals

miR-221 suppresses ICAM-1 translation and regulates interferon-{gamma}-induced ICAM-1 expression in human cholangiocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we tested the involvement of miRNA-mediated posttranscriptional regulation in IFN--induced ICAM-1 expression in cholangiocytes. Using both immortalized and nonimmortalized human cholangiocyte cell lines, we found that IFN- activated ICAM-1 transcription and increased ICAM-1 protein expression. Inhibition of ICAM-1 transcription could only partially block IFN--induced ICAM-1 expression at the protein level. In silico target prediction analysis revealed complementarity of miR-221 to the 3'-untranslated region of ICAM-1 mRNA. Targeting of ICAM-1 3'-untranslated region by miR-221 resulted in translational repres...
Source: AJP: Gastrointestinal and Liver Physiology - March 19, 2010 Category: Gastroenterology Authors: Hu, G., Gong, A.-Y., Liu, J., Zhou, R., Deng, C., Chen, X.-M. Tags: LIVER AND BILIARY TRACT Source Type: journals

MicroRNA-21 is upregulated during the proliferative phase of liver regeneration, targets Pellino-1, and inhibits NF-{kappa}B signalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, miR-21 expression was upregulated during early stages of liver regeneration. Targeting of Peli1 by miR-21 could potentially provide the basis for a negative feedback cycle regulating NF-B signaling. (Source: AJP: Gastrointestinal and Liver Physiology)
Source: AJP: Gastrointestinal and Liver Physiology - March 19, 2010 Category: Gastroenterology Authors: Marquez, R. T., Wendlandt, E., Galle, C. S., Keck, K., McCaffrey, A. P. Tags: LIVER AND BILIARY TRACT Source Type: journals

Comparison of human and porcine gastric clasp and sling fiber contraction by M2 and M3 muscarinic receptorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To compare the gastroesophageal junction of the human with the pig, M2 and M3 receptor densities and the potencies of M2 and M3 muscarinic receptor subtype selective antagonists were determined in gastric clasp and sling smooth muscle fibers. Total muscarinic and M2 receptors are higher in pig than human clasp and sling fibers. M3 receptors are higher in human compared with pig sling fibers but lower in human compared with pig clasp fibers. Clasp fibers have fewer M3 receptors than sling fibers in both humans and pigs. Similar to human clasp fibers, pig clasp fibers contract significantly less than pig sling fibers. Analys...
Source: AJP: Gastrointestinal and Liver Physiology - March 19, 2010 Category: Gastroenterology Authors: Vegesna, A. K., Braverman, A. S., Miller, L. S., Tallarida, R. J., Tiwana, M. I., Khayyam, U., Ruggieri, M. R. Tags: NEUROREGULATION AND MOTILITY Source Type: journals

Hemochromatosis and pregnancy: iron stores in the Hfe-/- mouse are not reduced by multiple pregnanciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, multiple pregnancies do not reduce body iron stores in Hfe–/– mice. (Source: AJP: Gastrointestinal and Liver Physiology)
Source: AJP: Gastrointestinal and Liver Physiology - March 19, 2010 Category: Gastroenterology Authors: Neves, J. V., Olsson, I. A. S., Porto, G., Rodrigues, P. N. Tags: LIVER AND BILIARY TRACT Source Type: journals

Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotypeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endogenous trypsin inhibitors are synthesized, stored, and secreted by pancreatic acinar cells. It is believed that they play a protective role in the pancreas by inhibiting trypsin within the cell should trypsinogen become prematurely activated. Rodent trypsin inhibitors are highly homologous to human serine protease inhibitor Kazal-type 1 (SPINK1). The mouse has one pancreatic trypsin inhibitor known as SPINK3, and the rat has two trypsin inhibitors commonly known as pancreatic secretory trypsin inhibitors I and II (PSTI-I and -II). Rat PSTI-I is a 61-amino acid protein that shares 65% sequence identity with mouse SPINK3...
Source: AJP: Gastrointestinal and Liver Physiology - March 19, 2010 Category: Gastroenterology Authors: Romac, J. M.-J., Ohmuraya, M., Bittner, C., Majeed, M. F., Vigna, S. R., Que, J., Fee, B. E., Wartmann, T., Yamamura, K.-i., Liddle, R. A. Tags: HORMONES AND SIGNALING Source Type: journals

Cooperation between HNF-1{alpha}, Cdx2, and GATA-4 in initiating an enterocytic differentiation program in a normal human intestinal epithelial progenitor cell lineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the intestinal epithelium, the Cdx, GATA, and HNF transcription factor families are responsible for the expression of differentiation markers such as sucrase-isomaltase. Although previous studies have shown that Cdx2 can induce differentiation in rat intestinal IEC-6 cells, no data are available concerning the direct implication of transcription factors on differentiation in human normal intestinal epithelial cell types. We investigated the role of Cdx2, GATA-4, and HNF-1 using the undifferentiated human intestinal epithelial crypt cell line HIEC. These transcription factors were tested on proliferation and expression o...
Source: AJP: Gastrointestinal and Liver Physiology - March 19, 2010 Category: Gastroenterology Authors: Benoit, Y. D., Pare, F., Francoeur, C., Jean, D., Tremblay, E., Boudreau, F., Escaffit, F., Beaulieu, J.-F. Tags: MUCOSAL BIOLOGY Source Type: journals

AE2 Cl-/HCOFormula exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anion secretion by colonic epithelium is dependent on apical CFTR-mediated anion conductance and basolateral ion transport. In many tissues, the NKCC1 Na+-K+-2Cl– cotransporter mediates basolateral Cl– uptake. However, additional evidence suggests that the AE2 Cl–/HCO3– exchanger, when coupled with the NHE1 Na+/H+ exchanger or a Na+-HCO3– cotransporter (NBC), contributes to HCO3– and/or Cl– uptake. To analyze the secretory functions of AE2 in proximal colon, short-circuit current (Isc) responses to cAMP and inhibitors of basolateral anion transporters were measured in muscle-stripp...
Source: AJP: Gastrointestinal and Liver Physiology - March 19, 2010 Category: Gastroenterology Authors: Gawenis, L. R., Bradford, E. M., Alper, S. L., Prasad, V., Shull, G. E. Tags: MUCOSAL BIOLOGY Source Type: journals

Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-{gamma} and tumor necrosis factor-{alpha}Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mucosal inflammation, through cytokines such as interferon- (IFN-) and tumor necrosis factor- (TNF-), has many effects on the intestinal epithelium, including selective translational inhibition of the cytoprotective protein heat shock protein 70 (Hsp70). To further elucidate the mechanisms underlying this effect, we examined the role of stress granules in mediating the actions of these proinflammatory cytokines. Using conditionally immortalized young adult mouse colonic epithelial cells, we demonstrate that IFN- and TNF-, which upregulate eukaryotic initiation factor- (eIF-2) phosphorylation and reduce Hsp70 translation, s...
Source: AJP: Gastrointestinal and Liver Physiology - March 19, 2010 Category: Gastroenterology Authors: Hu, S., Claud, E. C., Musch, M. W., Chang, E. B. Tags: INFLAMMATION/IMMUNITY/MEDIATORS Source Type: journals

Acute bacterial gastroenteritis linked to IBS in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A Canadian outbreak of acute bacterial gastroenteritis suggests the illness is associated with irritable bowel syndrome in children as well as adults. (Source: MedWire News - Gastroenterology)
Source: MedWire News - Gastroenterology - March 19, 2010 Category: Gastroenterology Source Type: news

New Agents for Metastatic Colorectal Cancer Increase Survival, Cost (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The newer agents used against metastatic colorectal cancer are associated with increased survival, and although the costs are substantial they fall within the range of most willingness-to-pay estimates, researchers said. (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - March 19, 2010 Category: Gastroenterology Source Type: news

Early or Delayed Cholecystectomy for Acute CholecystitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This meta-analysis considers the question of whether it is better to wait until cholecystitis subsides before gallbladder surgery. Medscape General Surgery (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - March 19, 2010 Category: Gastroenterology Tags: General Surgery Source Type: info

Studies Show Significant Increases Of C. Difficile Infections (CDI)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clostridium difficile infections (CDIs) are quickly becoming a significant issue in healthcare based upon recent studies. Preliminary data collected from nursing homes and highlighted in a Supplementary Pennsylvania Patient Safety Advisory shows that almost 40 percent of gastrointestinal infections reported are CDIs... (Source: GastroIntestinal News From Medical News Today)
Source: GastroIntestinal News From Medical News Today - March 19, 2010 Category: Gastroenterology Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Shift Workers At More Risk For Irritable Bowel SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nurses participating in shift work, especially those working rotating shifts, face a significantly increased risk of developing Irritable Bowel Syndrome (IBS) and abdominal pain compared to those working a standard day-time schedule, according to research published in the American Journal of Gastroenterology... (Source: GastroIntestinal News From Medical News Today)
Source: GastroIntestinal News From Medical News Today - March 19, 2010 Category: Gastroenterology Tags: Irritable-Bowel Syndrome Source Type: news

Prevention of Acupuncture Infection Needs More FocusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Prevention of Acupuncture Infection Needs More FocusCategory: Health NewsCreated: 3/18/2010 8:10:00 PMLast Editorial Review: 3/19/2010 (Source: MedicineNet Crohn's Disease General)
Source: MedicineNet Crohn's Disease General - March 19, 2010 Category: Gastroenterology Source Type: consumer

Carbaglu Approved for Rare Genetic DisorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Carbaglu Approved for Rare Genetic DisorderCategory: Health NewsCreated: 3/18/2010 6:10:00 PMLast Editorial Review: 3/19/2010 (Source: MedicineNet Crohn's Disease General)
Source: MedicineNet Crohn's Disease General - March 19, 2010 Category: Gastroenterology Source Type: consumer

Kids Not Only Obese, They're Extremely ObeseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Kids Not Only Obese, They're Extremely ObeseCategory: Health NewsCreated: 3/18/2010 4:53:00 PMLast Editorial Review: 3/19/2010 (Source: MedicineNet Crohn's Disease General)
Source: MedicineNet Crohn's Disease General - March 19, 2010 Category: Gastroenterology Source Type: consumer

Omega-3 May Safely Treat Precancerous Bowel PolypsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Omega-3 May Safely Treat Precancerous Bowel PolypsCategory: Health NewsCreated: 3/18/2010 4:10:00 PMLast Editorial Review: 3/19/2010 (Source: MedicineNet Crohn's Disease General)
Source: MedicineNet Crohn's Disease General - March 19, 2010 Category: Gastroenterology Source Type: consumer

SchistosomiasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: SchistosomiasisCategory: Diseases and ConditionsCreated: 3/19/2010 5:05:00 PMLast Editorial Review: 3/19/2010 5:05:15 PM (Source: MedicineNet Crohn's Disease General)
Source: MedicineNet Crohn's Disease General - March 19, 2010 Category: Gastroenterology Source Type: consumer

Solid-Pseudopapillary Neoplasm Of The Pancreas Or Pancreatic Endocrine Tumor?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Solid-pseudopapillary neoplasm (SPN) of the pancreas is relatively rare. There are some similarities between SPN and pancreatic endocrine tumor (PET), especially the non-functioning ones, in clinical and pathological manifestations... (Source: GastroIntestinal News From Medical News Today)
Source: GastroIntestinal News From Medical News Today - March 19, 2010 Category: Gastroenterology Tags: Pancreatic Cancer Source Type: news

Prevalence of inflammatory bowel disease in two districts of Sri Lanka: a hospital based surveyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The prevalence of IBD in this population was low compared to Western populations, but similar to some in Asia. There was a female preponderance for UC. UC was mainly mild, distal or left-sided, while CD mainly involved the large bowel. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - March 19, 2010 Category: Gastroenterology Authors: Madunil NiriellaArjuna De silvaAsangi DayaratneMadurangi AriyasingheMetthanandha NavaratneRanjith PeirisD Nandadeva SamarasekeraRaveendra SatharasingheSharman RajindrajithAnuradha DassanayakeA Rajitha WickramasingheH Janaka De silva Source Type: journals

Are There Prognostic Factors Related to Recurrence in Pancreatic Endocrine Tumors?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pancreatology 2010;10:3338 (DOI:10.1159/000217604) (Source: Pancreatology)
Source: Pancreatology - March 18, 2010 Category: Gastroenterology Source Type: journals

Detection of Gallstones in Acute Pancreatitis: When and How?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pancreatology 2010;10:2732 (DOI:10.1159/000224147) (Source: Pancreatology)
Source: Pancreatology - March 18, 2010 Category: Gastroenterology Source Type: journals

Gemcitabine Induces the VMP1-Mediated Autophagy Pathway to Promote Apoptotic Death in Human Pancreatic Cancer CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pancreatology 2010;10:1926 (DOI:10.1159/000264680) (Source: Pancreatology)
Source: Pancreatology - March 18, 2010 Category: Gastroenterology Source Type: journals