Gastroenterology 
This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. 
Subscribe to this data using MyMedWorm.
Subscribe to this data using GoogleReader.
Subscribe to this data using Bloglines.
Subscribe to this data using MyYahoo.
Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors
This page shows you the most recent publications within this specialty of the MedWorm directory.
125616 records returned
Upregulation of mucosal 5‐HT3 receptors is involved in restoration of colonic transit after pelvic nerve transection
Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusions & Inferences Colonic motility was restored to approximately 70% normal over 1 week without further improvement at 2 weeks. Enteric nervous system compensated by upregulating mucosal 5‐HT3, but not 5‐HT4, receptors. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - February 5, 2012 Category: Gastroenterology Authors: I. Gribovskaja‐RuppT. TakahashiT. RidolfiL. KosinskiK. Ludwig Source Type: research
Fluconazole/posaconazole/tretinoin interaction: Gastrointestinal and hepatic toxicity: case reportEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - February 5, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research
The association between two polymorphisms in the TS gene and risk of cancer: A systematic review and pooled analysisEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
AbstractThymidylate synthase (TS) is an important enzyme involved in folate metabolism and catalyzes methylation of dUMP to dTMP, which is essential for DNA replication. TSER and TS1494del6, two functionally important and ethnically diverse polymorphisms mapping to its gene region, are the most extensively studied. Considering the potential influence of altering TS activity, it is plausible that TS polymorphisms might play a role in the development of cancer. Although the effects of TS polymorphisms on susceptibility to human cancer have been investigated in many studies, the results remain conflicting rather than conclusi...
Source: International Journal of Cancer - February 5, 2012 Category: Cancer & Oncology Authors: Jue‐Yu ZhouRong ShiHai‐Lang YuYe ZengWen‐Ling ZhengWen‐Li Ma Tags: Epidemiology Source Type: research
Virus outbreak reported on 2 cruise shipsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
FORT LAUDERDALE, Fla., Feb. 4 (UPI) -- Outbreaks of a gastrointestinal virus have been reported on two Princess Cruises ships operating out of Port Everglades, Fla., officials said. (Source: Health News - UPI.com)
Source: Health News - UPI.com - February 4, 2012 Category: Consumer Health News Source Type: news
Norovirus causes most hospital outbreaksEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
WASHINGTON, Feb. 3 (UPI) -- Norovirus, a pathogen that often causes food poisoning and gastroenteritis, is the leading cause of infectious outbreaks in U.S. hospitals, researchers said. (Source: Health News - UPI.com)
Source: Health News - UPI.com - February 3, 2012 Category: Consumer Health News Source Type: news
Chronic Kidney Disease and End-Stage Renal Disease Predict Higher Risk of Mortality in Patients with Primary Upper Gastrointestinal BleedingEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Am J Nephrol 2012;35:216–224 (DOI:10.1159/000336107) (Source: Karger Publishers)
Source: Karger Publishers - February 3, 2012 Category: Cancer & Oncology Source Type: research
Invasive Ductal Carcinoma Arising from an Ectopic Pancreas in the Gastric Wall: A Long-Term Survival CaseEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Case Rep Oncol 2012;5:69–73 (DOI:10.1159/000335870) (Source: Karger Publishers)
Source: Karger Publishers - February 3, 2012 Category: Cancer & Oncology Source Type: research
Amoebic Liver Abscess in USAAmoebic Liver Abscess in USAEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
How common are amoebic liver abscesses, and how are they contracted in the first place? Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 3, 2012 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news
Update on Gastrointestinal Radiopharmaceuticals and Dosimetry EstimatesEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The gold standard technique for measuring gastric emptying is scintigraphy using radiolabeled test meals. Recently, a standardized radiolabeled solid meal has been proposed and adopted by many centers. There is still a need for alternative meals, and several such meals with demonstrated radiolabel stability have been evaluated in small numbers of subjects. Updated radiation dosimetry associated with these meals has been calculated for adult males and adult females with normal gastrointestinal transit as well as transit abnormalities. (Source: Seminars in Nuclear Medicine)
Source: Seminars in Nuclear Medicine - February 3, 2012 Category: Radiology Authors: Linda C. Knight Source Type: research
Advancing Gastric Emptying Studies: Standardization and New Parameters to Assess Gastric Motility and FunctionEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
For many years, gastric emptying (GE) studies were performed using various local protocols and different radiolabeled meals. This lack of standardization and normal values made the test results unreliable and difficult to compare from one site to another. A recent consensus has been published that now provides guidance and standardization on how to perform a radiolabeled solid-meal GE study. It is widely recognized, however, that simple measurement of total GE of a solid meal often does not provide an answer to the etiology of symptoms for a large number of patients who present with functional dyspepsia. Advances in our un...
Source: Seminars in Nuclear Medicine - February 3, 2012 Category: Radiology Authors: Alan H. Maurer Source Type: research
Scintigraphy for Evaluation of Patients for GI Motility Disorders—The Referring Physician's PerspectiveEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
This article discusses a physician's perspective on evaluating GI transit in patients with suspected GI disorders, particularly those involving the stomach for gastroparesis and the colon in patients with constipation. (Source: Seminars in Nuclear Medicine)
Source: Seminars in Nuclear Medicine - February 3, 2012 Category: Radiology Authors: Henry P. Parkman Source Type: research
Guest Editorial: Gastrointestinal Nuclear Medicine: Are We Making Progress?Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In my last guest editorial on gastrointestinal (GI) nuclear medicine in the Seminars in Nuclear Medicine in October 1995, I pointed out that there are few, if any, other nuclear medicine studies, such as gastric emptying, that are considered a gold standard with which other methods need to be compared. I stressed, however, that there was the need for continued efforts within the nuclear medicine community to prevent tarnishing this gold standard. Since then, we have made significant progress especially in standardizing gastric emptying. Additional progress, however, still needs to be made to prevent new imaging and nonimag...
Source: Seminars in Nuclear Medicine - February 3, 2012 Category: Radiology Authors: Alan H. Maurer Source Type: research
Letter from the Editors: Functional Studies of the Gastrointestinal TractEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
As pointed out by Dr. Alan Maurer in his guest editorial, it has been more than 15 years since he guest edited another Seminars issue, a two-part review of gastrointestinal (GI) nuclear imaging. A significant portion of the progress that has been made relates to attempted standardization of several of these studies. In particular, cooperative efforts between GI, radiology, and nuclear medicine societies have resulted in standardized methodology for gastric emptying studies. Whereas, half-time of emptying (T1/2) was previously considered the accepted key value or “gold standard,” current thoughts center more on the rete...
Source: Seminars in Nuclear Medicine - February 3, 2012 Category: Radiology Authors: Leonard M. Freeman, M. Donald Blaufox Source Type: research
Norovirus Causes Most Hospital Infection OutbreaksEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Title: Norovirus Causes Most Hospital Infection OutbreaksCategory: Health NewsCreated: 2/3/2012 11:01:00 AMLast Editorial Review: 2/3/2012 (Source: MedicineNet Crohn's Disease General)
Source: MedicineNet Crohn's Disease General - February 3, 2012 Category: Gastroenterology Source Type: news
Anemia May Boost Death Risk After StrokeEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Title: Anemia May Boost Death Risk After StrokeCategory: Health NewsCreated: 2/2/2012 2:06:00 PMLast Editorial Review: 2/3/2012 (Source: MedicineNet Crohn's Disease General)
Source: MedicineNet Crohn's Disease General - February 3, 2012 Category: Gastroenterology Source Type: news
cholestyramine, Questran, Questran LightEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Title: cholestyramine, Questran, Questran LightCategory: MedicationsCreated: 7/26/1999 10:41:00 PMLast Editorial Review: 2/3/2012 (Source: MedicineNet Crohn's Disease General)
Source: MedicineNet Crohn's Disease General - February 3, 2012 Category: Gastroenterology Source Type: news
hydrocortisone oral, Hydrocortone, CortefEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Title: hydrocortisone oral, Hydrocortone, CortefCategory: MedicationsCreated: 12/31/1997Last Editorial Review: 2/3/2012 (Source: MedicineNet Crohn's Disease General)
Source: MedicineNet Crohn's Disease General - February 3, 2012 Category: Gastroenterology Source Type: news
clarithromycin, Biaxin, Biaxin XLEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Title: clarithromycin, Biaxin, Biaxin XLCategory: MedicationsCreated: 12/31/1997Last Editorial Review: 2/3/2012 (Source: MedicineNet Crohn's Disease General)
Source: MedicineNet Crohn's Disease General - February 3, 2012 Category: Gastroenterology Source Type: news
CorrectionEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Benamouzig R, Uzzan B, Deyra J, et al. Prevention by daily soluble aspirin of colorectal adenoma recurrence: 4-year results of the APACC randomised trial. Gut 2012;61:255–61.
There are two numerical errors in the last sentence of the "Results" paragraph of the Abstract of this paper. This sentence should be read as follows: "Also, the proportion of patients with at least one advanced adenoma did not differ (10/102 (10 %) in the aspirin group vs 7/83 (8.4 %) in the placebo group; NS)." (Source: Gut)
Source: Gut - February 3, 2012 Category: Gastroenterology Tags: PostScript Source Type: research
The need for standardised outcome reporting in colorectal surgeryEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
We were interested to read the paper by Morris et al demonstrating significant variation in 30-day postoperative mortality following major colorectal cancer surgery in National Health Service hospitals in England.1 While we agree that understanding the underlying causes of this variation will be invaluable to inform best practice, we think that it is necessary to choose a definition of postoperative mortality that provides information relevant to patients as well as clinicians. In cardiothoracic surgery, this issue has been debated for some years, resulting in a measure of ‘operative mortality’ which encompasse...
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Whistance, R. N., Blencowe, N. S., Blazeby, J. M. Tags: PostScript Source Type: research
Authors' responseEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Patients with hyperplastic polyposis syndrome (HPS) harbour multiple colorectal hyperplastic polyps and are at risk of developing colorectal cancer (CRC).1 2 In two recent studies from our study group, we described the risk of CRC in patients with HPS during follow-up and the RR of CRC/polyps in first-degree relatives (FDRs) of patients with HPS compared to the general population.1 2 In reaction to our manuscripts, Orlowska3 recommends that a distinction be made between sessile serrated adenomas and traditional serrated adenomas. We agree with this remark, considering that these serrated polyp subtypes differ in histologic...
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Boparai, K. S., Reitsma, J. B., Dekker, E. Tags: PostScript Source Type: research
Hyperplastic polyposis syndrome and the risk of colorectal cancerEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
I read with great interest the two reports by Boparai and coworkers in Gut on the increased risk of colorectal carcinoma (CRC) in 77 hyperplastic/serrated polyposis syndrome (HPS) patients during follow-up1 and in 347 HPS first-degree relatives (FDRs).2 To date, follow-ups have been performed in only 43/308 (14.0%) HPS patients and HPS coexistence with CRC in FDRs has been analysed in only 29/308 (9.4%) HPS patients described up to the end of 2009 (table 1). Nevertheless, there are some points to be explained:The term ‘(sessile) serrated adenoma’ should be abbreviated as SSA, instead of SA (serrated adenoma). S...
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Orlowska, J. Tags: PostScript Source Type: research
Authors' responseEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
We thank Dr Ben-Horin for his comments published in the February 2012 issue of Gut1 in respect of our small, first in man, trial of rituximab for ulcerative colitis.2 We sympathise with his concern that potentially useful treatments should not be ignored on the basis of underpowered trials, however the p value of 1.0 for the primary endpoint comparison between rituximab and placebo seems adequate justification for our negative conclusion regarding efficacy and is quite different from the p=0.22 that Ben-Horin cites for his hypothetical discussion of ACT1. The use of remission rather than response for the primary endpoint i...
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Rhodes, J. M. Tags: PostScript Source Type: research
Virulence factors or ancestral origin of Helicobacter pylori: which is a better predictor of gastric cancer risk?Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
We examined the association between virulence factors, including cag pathogenicity island, vacA, babA, iceA and OipA, of H pylori strains isolated from Columbian subjects and clinical outcomes.2 We found that although OipA and cag pathogenicity island are linked with each other, only... (Source: Gut)
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Shiota, S., Matsunari, O., Watada, M., Yamaoka, Y. Tags: PostScript Source Type: research
Allogeneic mesenchymal stem cell transplantation in seven patients with refractory inflammatory bowel diseaseEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
We refer to two articles by Duijvestein et al and Ciccocioppo et al1 2 in which the authors suggest that administration of autologous bone marrow-derived mesenchymal stem cells (MSCs) is safe and feasible in the treatment of refractory Crohn's disease (CD). However, to date there are few data about allogeneic MSC transplantation (MSCT) for patients with inflammatory bowel disease (IBD). We wish to report our experience of allogeneic MSCT in seven patients with IBD. Infused allogeneic MSCs were obtained from the bone marrow or umbilical cord. Bone marrow was aspirated from healthy relatives of three patients. Umbilical cord...
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Liang, J., Zhang, H., Wang, D., Feng, X., Wang, H., Hua, B., Liu, B., Sun, L. Tags: PostScript Source Type: research
GI highlights from the literatureEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Basic sciencePreservation of immune quiescence in inflammatory bowel disease: the role of dendritic cell A20 expression Hammer GE, Turer EE, Taylor KE, et al. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol 2011;12:1184–93. doi:10.1038/ni.2135 Dendritic cells (DCs) are known to play a key role in innate immune activation, but may also regulate immune homeostasis. This recent paper from Averil Ma and colleagues at the University of California, San Francisco, examined the role of the ubiquitin-editing protein A20 within DCs to identify how ...
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: McLean, M. H. Tags: JournalScan Source Type: research
Shared decision making in inflammatory bowel disease: helping patients understand the tradeoffs between treatment optionsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The treatment of inflammatory bowel disease is becoming more complicated with new medications and new treatment paradigms. Although data are accumulating that the earlier use of immunomodulators and anti-tumor necrosis factor agents are more effective than the standard "step-up" pyramidal treatment algorithm, patients may not be comfortable with this more intensive therapeutic approach. The process of shared decision making engages patients in treatment decisions to optimize the chance that a chosen therapy matches their personal preferences for care. Decision aids are standard shared decision making tools, which are used ...
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Siegel, C. A. Tags: GUT Recent advances in clinical practice, Gut Education Source Type: research
Pancreatic ductal adenocarcinoma and acinar cells: a matter of differentiation and development?Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Pancreatic ductal adenocarcinoma (PDAC) has long been considered to arise from pancreatic ducts on the basis of its morphology, the occurrence of dysplasia in putative preneoplastic ductal lesions, and the absence of acinar dysplasia in the pancreas of patients with PDAC. However, evidence gathered through both in vitro studies and—more importantly—genetic mouse models of PDAC shows that ductal-type tumours can arise from acinar cells. These findings raise new important questions related to PDAC pathophysiology and call for in-depth studies of acinar cell differentiation in order to better understand PDAC biolo...
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Rooman, I., Real, F. X. Tags: GUT Recent advances in basic science, Pancreas and biliary tract, Gut Education Source Type: research
Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancerEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusions
These findings imply an important role for histone deacetylation in the downregulation of E-cadherin in human pancreatic cancer. Recruitment of HDACs to the CDH1 promoter is regulated by the transcription factor ZEB1, and inhibition of HDACs may be a promising antitumour therapy for pancreatic cancer. (Source: Gut)
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Aghdassi, A., Sendler, M., Guenther, A., Mayerle, J., Behn, C.-O., Heidecke, C.-D., Friess, H., Buchler, M., Evert, M., Lerch, M. M., Weiss, F. U. Tags: Pancreas and biliary tract, Pancreatic cancer Source Type: research
Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinomaEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusion
A 14 immune-gene signature, which identifies molecular cues driving tumour infiltration by lymphocytes, accurately predicts survival of patients with HCC especially in early disease. (Source: Gut)
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Chew, V., Chen, J., Lee, D., Loh, E., Lee, J., Lim, K. H., Weber, A., Slankamenac, K., Poon, R. T. P., Yang, H., Ooi, L. L. P. J., Toh, H. C., Heikenwalder, M., Ng, I. O. L., Nardin, A., Abastado, J.-P. Tags: Unlocked, Hepatic cancer Hepatology Source Type: research
Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injuryEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusions
These results demonstrate the successful pharmacological inhibition of hepatic monocyte/macrophage infiltration by blocking MCP-1 during chronic liver damage in two in vivo models. The associated ameliorated steatosis development suggests that inhibition of MCP-1 is an interesting novel approach for pharmacological treatment in liver inflammation and steatohepatitis. (Source: Gut)
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Baeck, C., Wehr, A., Karlmark, K. R., Heymann, F., Vucur, M., Gassler, N., Huss, S., Klussmann, S., Eulberg, D., Luedde, T., Trautwein, C., Tacke, F. Tags: Nonalcoholic steatosis Hepatology Source Type: research
Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastographyEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusion
NAFLD is found in over a quarter of the general adult Chinese population, but the proportion of patients with advanced fibrosis is low. Modest alcohol consumption does not increase the risk of fatty liver or liver fibrosis. (Source: Gut)
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Wong, V. W.-S., Chu, W. C.-W., Wong, G. L.-H., Chan, R. S.-M., Chim, A. M.-L., Ong, A., Yeung, D. K.-W., Yiu, K. K.-L., Chu, S. H.-T., Woo, J., Chan, F. K.-L., Chan, H. L.-Y. Tags: Cirrhosis, Nonalcoholic steatosis Hepatology Source Type: research
Higher adenoma detection rates with cap-assisted colonoscopy: a randomised controlled trialEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusions
CAC detected a 13% higher number of subjects with at least one adenoma and 59% higher adenomas per subject. CAC is a safe, effective and practical means to improve adenoma detection rates.
Clinical Trial Registration
NCT 01211132. (Source: Gut)
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Rastogi, A., Bansal, A., Rao, D. S., Gupta, N., Wani, S. B., Shipe, T., Gaddam, S., Singh, V., Sharma, P. Tags: Endoscopy, Colon cancer Source Type: research
A rare gastrointestinal presentation of a common malignancyEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Clinical presentation A 61-year-old man presented with a 4-week history of rectal bleeding, constipation, bloating, abdominal distension and low back pain. His bowels had not opened for 4 days prior to admission. Physical examination revealed a distended, tympanic abdomen. Routine laboratory tests confirmed renal failure (urea 13 mmol/l, creatinine 200 μmol/l), hypercalcaemia (3.7 mmol/l), albumin 32 g/l and C-reactive protein (CRP) 25 mg/l. Parathormone was suppressed (7 pg/l (15–65)). Abdominal x-ray suggested an ileus. CT abdomen revealed mural thickening of the left hemi-colo...
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: McCorry, R. B., Nair, B., Mooney, P., Shields, P. L. Tags: GUT Snapshot Editor ' s quiz: GI snapshot Source Type: research
Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumourEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusion
Our results suggest that GIST is not, in epigenetic terms, a uniform disease and that DNA methylation in a set of genes is associated with aggressive clinical behavior and unfavorable prognosis. The genes identified may potentially serve as biomarkers for predicting aggressive GISTs with poor survivability. (Source: Gut)
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Okamoto, Y., Sawaki, A., Ito, S., Nishida, T., Takahashi, T., Toyota, M., Suzuki, H., Shinomura, Y., Takeuchi, I., Shinjo, K., An, B., Ito, H., Yamao, K., Fujii, M., Murakami, H., Osada, H., Kataoka, H., Joh, T., Sekido, Y., Kondo, Y. Tags: GI neoplasia Source Type: research
Serological response to the 2009 H1N1 influenza vaccination in patients with inflammatory bowel diseaseEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusions
Patients with IBD vaccinated with the 2009 H1N1 influenza vaccine had a low rate of seroprotection, particularly among those who were immunosuppressed. Although there is a need for studies of the clinical benefit of vaccines in this population, patients with IBD need to be aware of this reduced immunogenicity. (Source: Gut)
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Cullen, G., Bader, C., Korzenik, J. R., Sands, B. E. Tags: Inflammatory bowel disease Source Type: research
Interleukin-1{beta} (IL-1{beta}) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitisEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusion
Regardless of whether they harbour a colitogenic microbiota, loss of TLR5 predisposes mice to colitis triggered by immune dysregulation via an IL-1β-dependent pathway. (Source: Gut)
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Carvalho, F. A., Nalbantoglu, I., Ortega-Fernandez, S., Aitken, J. D., Su, Y., Koren, O., Walters, W. A., Knight, R., Ley, R. E., Vijay-Kumar, M., Gewirtz, A. T. Tags: Inflammatory bowel disease Source Type: research
Visceral hypersensitivity in endometriosis: a new target for treatment?Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusion
Visceral hypersensitivity is extremely common in endometriosis and could be intensifying the pain. This finding might explain why mildly affected individuals often complain of severe symptoms out of proportion to the extent of their disease. This study has introduced a completely new concept into the understanding of pain in endometriosis and could open up new opportunities for treatment. (Source: Gut)
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Issa, B., Onon, T. S., Agrawal, A., Shekhar, C., Morris, J., Hamdy, S., Whorwell, P. J. Tags: Irritable bowel syndrome Neurogastroenterology Source Type: research
Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cellsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusions
B infantis administration to humans selectively promotes immunoregulatory responses, suggesting that this microbe may have therapeutic utility in patients with inflammatory disease. Cross-talk between multiple pattern-recognition receptors and metabolic pathways determines the innate and subsequent T regulatory cell response to B infantis. These findings link nutrition, microbiota and the induction of tolerance within the gastrointestinal mucosa. (Source: Gut)
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Konieczna, P., Groeger, D., Ziegler, M., Frei, R., Ferstl, R., Shanahan, F., Quigley, E. M. M., Kiely, B., Akdis, C. A., O'Mahony, L. Tags: Editor's choice Gut microbiota Source Type: research
Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancerEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusion
This mouse line is the first genetically engineered mouse model of DGC and is very useful for clarifying the mechanism underlying gastric carcinogenesis, and provides a new approach to the treatment and prevention of DGC. (Source: Gut)
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Shimada, S., Mimata, A., Sekine, M., Mogushi, K., Akiyama, Y., Fukamachi, H., Jonkers, J., Tanaka, H., Eishi, Y., Yuasa, Y. Tags: Stomach and duodenum, Press releases, Pancreatic cancer Source Type: research
Mechanism of association between BMI and dysfunction of the gastro-oesophageal barrier in patients with normal endoscopyEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusion
The association between reflux and BMI may be largely explained by effects of increased intra-abdominal pressure. However, the reduced LOS pressure associated with BMI may be mediated by another mechanism or effects of chronic rather than acute elevation of intra-abdominal pressure. (Source: Gut)
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Derakhshan, M. H., Robertson, E. V., Fletcher, J., Jones, G.-R., Lee, Y. Y., Wirz, A. A., McColl, K. E. L. Tags: Oesophagus Source Type: research
Reasons to consider earlier treatment of chronic HBV infectionsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Introduction Chronic hepatitis B virus (HBV) infection is a serious public health problem, leading to cirrhosis, hepatocellular carcinoma (HCC) and liver failure. In highly endemic areas and among immigrants from these areas, most cases of chronic hepatitis B are due to HBV infection at birth or during the first year of life. Cirrhosis and HCC may occur at any age, but infections early in life are typically asymptomatic for the first few decades. Sharp rises in the incidence of fibrosis, cirrhosis and HCC generally do not appear until after the age of 30, the incidence of HCC showing a sharp rise after the age of 40. Appro...
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Zoulim, F., Mason, W. S. Tags: Hepatitis B, Hepatic cancer, Guidelines Leading article Source Type: research
Bifidobacteria and subsets of dendritic cells: friendly players in immune regulation!Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The mammalian gastrointestinal tract harbours a vast number of bacterial residents, recently referred to as the microbiota, which are instrumental in supporting energy metabolism and immune function of the host. A large number of studies have highlighted the fact that certain (pathogenic) micro-organisms can be harmful to the health of their host, while more recently an increasing number of papers have attributed direct beneficial health effects to the gut microbial community. As these bacteria encode 100 times more genes than present in the human genome, the partnership of the host with its microbiota constitute a ‘...
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Grangette, C. Tags: Commentary Source Type: research
A ZEB1-HDAC pathway enters the epithelial to mesenchymal transition world in pancreatic cancerEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Epithelial to mesenchymal transition (EMT) correlates with high-grade malignancy including the competence to form metastases. In addition, EMT has recently been linked to cellular self-renewal programmes of cancer stem cells and apoptosis/anoikis resistance, which are all features of therapeutic resistance. The EMT programme is driven by several transcription factors (TFs), such as the transcriptional regulators SNAIL, SLUG, ZEB1 and ZEB2 and the basic helix–loop–helix factors E47 and TWIST. These proteins target and repress the CDH1 gene, which encodes for E-cadherin, an important caretaker of the epithelial s...
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Schneider, G., Kramer, O. H., Saur, D. Tags: Commentary Source Type: research
Highlights from this issueEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Luminal GIH1N1 influenza vaccination and IBD The global pandemic of novel influenza A (H1N1) affected 70 countries in 2009. There was particular concern for infection in immunocompromised patients, including those with IBD. The 2009 H1N1 influenza vaccine produced seroprotection rates of >85% in the general population but there are no data on the immunogenicity of the vaccine in patients with IBD. In this issue of Gut, Cullen et al report their observational prospective open-label study which examined the immunogenicity of the 2009 H1N1 influenza vaccine in IBD patients. Patients with IBD vaccinated with the 2009 H1N1 i...
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: El-Omar, E., Grady, W., Gerbes, A. Tags: Digest Source Type: research
Warshaw's technique: what's the point?Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
(Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - February 3, 2012 Category: Gastroenterology Authors: Marco InamaGiovanni ButturiniClaudio Bassi Source Type: research
Meta‐analysis of one‐ vs. two‐stage laparoscopic/endoscopic management of common bile duct stonesEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusions: Outcomes after one‐stage laparoscopic/endoscopic management of bile duct stones are no different to the outcomes after two‐stage management. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - February 3, 2012 Category: Gastroenterology Authors: Nicholas AlexakisSaxon Connor Source Type: research
Transgenic overexpression of intraislet ghrelin does not affect insulin secretion or glucose metabolism in vivoEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Whereas ghrelin is produced primarily in the stomach, a small amount of it is produced in pancreatic islets. Although exogenous administration of ghrelin suppresses insulin secretion in vitro or in vivo, the role of intraislet ghrelin in the regulation of insulin secretion in vivo remains unclear. To understand the physiological role of intraislet ghrelin in insulin secretion and glucose metabolism, we developed a transgenic (Tg) mouse model, rat insulin II promoter ghrelin-internal ribosomal entry site-ghrelin O-acyl transferase (RIP-GG) Tg mice, in which mouse ghrelin cDNA and ghrelin O-acyltransferase are overexpressed ...
Source: AJP: Endocrinology and Metabolism - February 3, 2012 Category: Endocrinology Authors: Bando, M., Iwakura, H., Ariyasu, H., Hosoda, H., Yamada, G., Hosoda, K., Adachi, S., Nakao, K., Kangawa, K., Akamizu, T. Tags: Articles Source Type: research
