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Editorial Board
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - June 15, 2013 Category: Gastroenterology Source Type: research

Gut-liver axis and fibrosis in nonalcoholic fatty liver disease: An input for novel therapies
Abstract: Non-alcoholic fatty liver disease is a multifactorial condition, ranging from simple steatosis to non-alcoholic steatohepatitis with or without fibrosis. In non-alcoholic fatty liver disease, alteration of gut microbiota and increased intestinal permeability increase exposure of the liver to gut-derived bacterial products: lipopolysaccharides and unmethylated CpG DNA. These products stimulate innate immune receptors, namely Toll-like receptors, which activate signalling pathways involved in liver inflammation and fibrogenesis. Currently, there are several studies on the involvement of lipopolysaccharide-activated...
Source: Digestive and Liver Disease - June 15, 2013 Category: Gastroenterology Authors: Otilia E. Frasinariu, Sara Ceccarelli, Anna Alisi, Evelina Moraru, Valerio Nobili Tags: Review Articles Source Type: research

Smad7 antisense oligonucleotide-based therapy for inflammatory bowel diseases
Abstract: The aetiology of both Crohn's disease and ulcerative colitis, the major forms of inflammatory bowel diseases in human beings, remains unknown. However, compelling evidence suggests that the associated pathological process in inflammatory bowel disease is driven by an excessive immune response directed against normal components of the bacterial microflora and marked by defects in counter-regulatory mechanisms, such as those involving transforming growth factor-β1. Indeed, a diminished activity of transforming growth factor-β1, as indicated by a reduced phosphorylation of Smad3, a signalling molecule associated w...
Source: Digestive and Liver Disease - June 15, 2013 Category: Gastroenterology Authors: Francesca Zorzi, Erika Angelucci, Silvia Sedda, Francesco Pallone, Giovanni Monteleone Tags: Progress Report Source Type: research

New insights on the pathomechanisms of inflammatory bowel disease
Abstract Pathogenesis of inflammatory bowel disease (IBD) remains an enigma on whether germs and genes or a combination of these two factors with excessive immune responses to gut‐associated bacteria explicates its pathomechanisms. The incidence of IBD is 0.76747/100 000 in Central Indonesia based on Project Indonesian IBD Access 2012 progress report. This result with other epidemiological studies in Asia may reflect a conclusively increased rates, while its pathogenesis still mistified by doubts. However, knowledge on the pathophysiology of IBD is vastly growing to abreast new developments. Series of novel updates in co...
Source: Chinese Journal of Digestive Diseases - June 15, 2013 Category: Gastroenterology Authors: Murdani Abdullah, Ari Fahrial Syam, Marcellus Simadibrata, Jeffri Gunawan, Dadang Makmun, Abdul Aziz Rani Tags: Invited Review Source Type: research

Clinical but not histological factors predict long‐term prognosis in patients with histologically advanced non‐decompensated alcoholic liver disease
ConclusionIn out‐patients with biopsy‐proven histologically advanced non‐decompensated ALD, clinical but not histological factors determine prognosis. Persistent alcohol intake is the strongest predictor and smoking habit, age and serum albumin are also independently prognostic. Abstinence from alcohol and smoking cessation should be the priorities in the long‐term management of ALD.This article is protected by copyright. All rights reserved. (Source: Liver International)
Source: Liver International - June 15, 2013 Category: Gastroenterology Authors: Steven Masson, Ingrid Emmerson, Elsbeth Henderson, Emma Fletcher, Alastair D Burt, Christopher P Day, Stephen Stewart Tags: Original Article Source Type: research

Normal values for esophageal high‐resolution manometry
Conclusions & InferencesOverall, the normal values of esophageal HRM parameters obtained with the Unisensor catheter resemble those of the previously published series. Marked differences in upper limits of normal were found for parameters related to the esophageal sphincters and TZ length. Users of HRM should be aware of these differences and define pathology based on comparison to appropriate normal values. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - June 15, 2013 Category: Gastroenterology Authors: A. Bogte, A. J. Bredenoord, J. Oors, P. D. Siersema, A. J. P. M. Smout Tags: Original Article Source Type: research

Chemical variability in the essential oils from leaves of Syzygium jambos
Syzygium jambos (L.) Alston, Myrtaceae, occurs in tropical regions and is a widespread medicinal plant used to treat several diseases, such as hemorrhage, dysentery, diabetes, inflammation, diabetes and gastrointestinal disorders. Leaf essential oils of ten specimens of S. jambos collected from two localities of Central Brazilian Cerrado were investigated by GC-MS. Soil and foliar nutrients were analyzed to determine the mineral compositions. The aims of this study was to evaluate the influence of environmental factors on chemical composition of leaf essential oils of S. jambos. Studies on the influence of environmental fa...
Source: Revista Brasileira de Farmacognosia - June 15, 2013 Category: Drugs & Pharmacology Source Type: research

Endoscopy in the diagnosis of intestinal graft‐versus‐host disease: Is lower endoscopy with biopsy as effective in diagnosis as upper endoscopy combined with lower endoscopy?
ConclusionUse of sigmoid biopsy for GvHD diagnosis is effective, safe, and less expensive compared to other endoscopic interventions. Pediatr Blood Cancer 2013;9999:XX–XX. © 2013 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - June 15, 2013 Category: Cancer & Oncology Authors: Kody R. Crowell, Raza A. Patel, Mark Fluchel, Amy Lowichik, Staci Bryson, John F. Pohl Tags: Research Article Source Type: research

A low-carbohydrate/high-fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance
In conclusion, a low-carbohydrate/high-fat diet reduced blood pressure and improved arterial function in SHR without producing signs of insulin resistance or altering insulin-mediated signaling in the heart, skeletal muscle, or vasculature. (Source: AJP: Heart and Circulatory Physiology)
Source: AJP: Heart and Circulatory Physiology - June 15, 2013 Category: Cardiology Authors: Bosse, J. D., Lin, H. Y., Sloan, C., Zhang, Q.-J., Abel, E. D., Pereira, T. J., Dolinsky, V. W., Symons, J. D., Jalili, T. Tags: INTEGRATIVE CARDIOVASCULAR PHYSIOLOGY AND PATHOPHYSIOLOGY Source Type: research

Preterm human milk contains a large pool of latent TGF-{beta}, which can be activated by exogenous neuraminidase
In this study we hypothesized that premature infants remain at higher risk of NEC than full-term infants, even when they receive their own mother's milk, because preterm human milk contains less bioactive TGF-β than full-term milk. Our objective was to compare TGF-β bioactivity in preterm vs. full-term milk and identify factors that activate milk-borne TGF-β. Mothers who delivered between 23 0/7 and 31 6/7 wk or at ≥37 wk of gestation provided milk samples at serial time points. TGF-β bioactivity and NF-B signaling were measured using specific reporter cells and in murine intestinal tissue explants. ...
Source: AJP: Gastrointestinal and Liver Physiology - June 15, 2013 Category: Gastroenterology Authors: Namachivayam, K., Blanco, C. L., Frost, B. L., Reeves, A. A., Jagadeeswaran, R., MohanKumar, K., Safarulla, A., Mandal, P., Garzon, S. A., Raj, J. U., Maheshwari, A. Tags: TRANSLATIONAL PHYSIOLOGY Source Type: research

Hydrogen sulfide, another simple gas with complex biology
(Source: AJP: Gastrointestinal and Liver Physiology)
Source: AJP: Gastrointestinal and Liver Physiology - June 15, 2013 Category: Gastroenterology Authors: Guettler, C., Kubes, P. Tags: EDITORIAL FOCUS Source Type: research

Hydrogen sulfide modulates sinusoidal constriction and contributes to hepatic micorcirculatory dysfunction during endotoxemia
This study is the first to demonstrate a vasoconstrictor action of H2S on the hepatic sinusoid and provides a possible mechanism for the protective effect of PAG treatment during sepsis. (Source: AJP: Gastrointestinal and Liver Physiology)
Source: AJP: Gastrointestinal and Liver Physiology - June 15, 2013 Category: Gastroenterology Authors: Norris, E. J., Feilen, N., Nguyen, N. H., Culberson, C. R., Shin, M. C., Fish, M., Clemens, M. G. Tags: LIVER AND BILIARY TRACT Source Type: research

Glyoxalate reductase/hydroxypyruvate reductase interacts with the sodium-dependent vitamin C transporter-1 to regulate cellular vitamin C homeostasis
The human sodium-dependent vitamin C transporter 1 (hSVCT1) contributes to cellular uptake of ascorbic acid (AA). Although different aspects of hSVCT1 cell biology have been extensively studied, nothing is currently known about the broader hSVCT1 interactome that modulates its role in cellular physiology. Here, we identify the enzyme human glyoxalate reductase/hydroxypyruvate reductase (hGR/HPR) as an hSVCT1 associated protein by yeast two-hybrid (Y2H) screening of a human liver cDNA library. The interaction between hSVCT1 and hGR/HPR was further confirmed by in vitro GST pull-down assay, in vivo coimmunoprecipitation and ...
Source: AJP: Gastrointestinal and Liver Physiology - June 15, 2013 Category: Gastroenterology Authors: Subramanian, V. S., Nabokina, S. M., Patton, J. R., Marchant, J. S., Moradi, H., Said, H. M. Tags: LIVER AND BILIARY TRACT Source Type: research

Pathogenic role of mast cells in experimental eosinophilic esophagitis
In conclusion, we provide for the first time direct evidence that mast cell promotes muscle cell hyperplasia and hypertrophy and may have a significant role in promoting esophageal functional abnormalities in EoE. (Source: AJP: Gastrointestinal and Liver Physiology)
Source: AJP: Gastrointestinal and Liver Physiology - June 15, 2013 Category: Gastroenterology Authors: Niranjan, R., Mavi, P., Rayapudi, M., Dynda, S., Mishra, A. Tags: INFLAMMATION/IMMUNITY/MEDIATORS Source Type: research

Glucose metabolism in the Belgrade rat, a model of iron-loading anemia
In this study, we characterized the glycometabolic status of the Belgrade rat. Belgrade rats displayed normal glycemic control. Insulin signaling and secretion were not impaired, and pancreatic tissue did not incur damage despite high levels of nonheme iron. These findings suggest that loss of DMT1 protects against oxidative damage to the pancreas and helps to maintain insulin sensitivity despite iron overload. Belgrade rats had lower body weight but increased food consumption compared with heterozygous littermates. The unexpected energy balance was associated with increased urinary glucose output. Increased urinary excret...
Source: AJP: Gastrointestinal and Liver Physiology - June 15, 2013 Category: Gastroenterology Authors: Jia, X., Kim, J., Veuthey, T., Lee, C.-H., Wessling-Resnick, M. Tags: PANCREAS Source Type: research

Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas
In conclusion, coexpression of progenitor cell markers and differentiated cell markers with ZSCAN4 in each compartment of the pancreas may indicate the presence of facultative progenitors for both exocrine and endocrine cells in the adult pancreas. (Source: AJP: Gastrointestinal and Liver Physiology)
Source: AJP: Gastrointestinal and Liver Physiology - June 15, 2013 Category: Gastroenterology Authors: Ko, S. B. H., Azuma, S., Yokoyama, Y., Yamamoto, A., Kyokane, K., Niida, S., Ishiguro, H., Ko, M. S. H. Tags: PANCREAS Source Type: research

The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty
Rapid degradation of glucagon-like peptide-1 (GLP-1) by dipeptidyl peptidase-4 suggests that endogenous GLP-1 may act locally before being degraded. Signaling via the vagus nerve was investigated in 20 truncally vagotomized subjects with pyloroplasty and 10 matched healthy controls. Subjects received GLP-1 (7-36 amide) or saline infusions during and after a standardized liquid mixed meal and a subsequent ad libitum meal. Despite no effect on appetite sensations, GLP-1 significantly reduced ad libitum food intake in the control group but had no effect in the vagotomized group. Gastric emptying was accelerated in vagotomized...
Source: AJP: Gastrointestinal and Liver Physiology - June 15, 2013 Category: Gastroenterology Authors: Plamboeck, A., Veedfald, S., Deacon, C. F., Hartmann, B., Wettergren, A., Svendsen, L. B., Meisner, S., Hovendal, C., Vilsboll, T., Knop, F. K., Holst, J. J. Tags: HORMONES AND SIGNALING Source Type: research

Is apolipoprotein A-IV rate limiting in the intestinal transport and absorption of triglyceride?
Apolipoprotein A-IV (apoA-IV) is synthesized by the intestine and secreted when dietary fat is absorbed and transported into lymph associated with chylomicrons. We have recently demonstrated that loss of apoA-IV increases chylomicron size and delays its clearance from the blood. There is still uncertainty, however, about the precise role of apoA-IV on the transport of dietary fat from the intestine into the lymph. ApoA-IV knockout (KO) mice do not have a gross defect in dietary lipid absorption, as measured by oral fat tolerance and fecal fat measurements. Here, using the in vivo lymph fistula mouse model, we show that the...
Source: AJP: Gastrointestinal and Liver Physiology - June 15, 2013 Category: Gastroenterology Authors: Kohan, A. B., Wang, F., Li, X., Vandersall, A. E., Huesman, S., Xu, M., Yang, Q., Lou, D., Tso, P. Tags: MUCOSAL BIOLOGY Source Type: research

Corrigendum
(Source: AJP: Gastrointestinal and Liver Physiology)
Source: AJP: Gastrointestinal and Liver Physiology - June 15, 2013 Category: Gastroenterology Tags: CORRIGENDA Source Type: research

Clostridium difficile in children: a review of existing and recently uncovered evidence.
Abstract The clinical significance of the presence of Clostridium difficile in children's faeces remains uncertain using current diagnostic procedures. Clostridium difficile is a relatively common finding in infants with no symptoms of gastrointestinal disease, suggesting it may be an incidental finding and form part of the normal gut micro-flora in this age group. On the other hand, particularly in older children or those with significant co-morbidity, there are examples where C. difficile causes disease and exerts considerable morbidity and even mortality (C. difficile infection, CDI). Between these extremes lie ...
Source: Adv Data - June 14, 2013 Category: Epidemiology Authors: Morris O, Tebruegge M, Pallett A, Green SM, Pearson AD, Tuck A, Clarke SC, Roderick P, Faust SN Tags: Adv Exp Med Biol Source Type: research

A suicidal poisoning due to tramadol. A metabolic approach to death investigation
Abstract: Tramadol is a synthetic opioid, widely used for post-surgical and chronic pain. Lethal overdose due only to tramadol is not common; more often the poisoning is due to tramadol in combination with other substances.Reported is a suicidal case of lethal tramadol poisoning in a 48-year-old woman. Tramadol and its metabolites O-desmethyltramadol (M1), N-desmethyltramadol (M2), N,N-didesmethyltramadol (M3), N,O-didesmethyltramadol (M5) were detected by GC/MS in biological fluids (femoral blood, bile, urine, gastric content) and viscera (brain, lung, liver and kidney). The tramadol concentration in femoral blood was 61....
Source: Journal of Forensic and Legal Medicine - June 14, 2013 Category: Forensic Medicine Authors: Nunziata Barbera, Marco Fisichella, Andrea Bosco, Francesca Indorato, Giorgio Spadaro, Guido Romano Tags: Case Reports Source Type: research

Comparative effect of clopidogrel and aspirin versus aspirin alone on laboratory parameters: a retrospective, observational, cohort study
Conclusion: Our findings suggested that hematological adverse effects may be greater with combination therapy of clopidogrel plus aspirin than with aspirin monotherapy. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 14, 2013 Category: Cardiology Authors: Yasuo TakahashiYayoi NishidaTomohiro NakayamaSatoshi Asai Source Type: research

The effect of rocuronium and sugammadex on neuromuscular blockade in a child with congenital myotonic dystrophy type 1
Summary Myotonic dystrophy type 1 (MD1) is the commonest muscular dystrophy found in adults; however, it may present in the neonatal period with hypotonia, talipes, poor feeding, and respiratory failure. Inheritance is autosomal dominant with a defect in the DMPK gene found on the long arm of chromosome 19 with variable expansion of the cytosine–thymine–guanine (CTG) triplet repeat. A 14‐month‐old boy with congenital MD type 1 was scheduled for percutaneous endoscopic gastrostomy (PEG) insertion, orchidopexy, and division of tongue‐tie. Following induction of anesthesia, acceleromyography was used to monitor neur...
Source: Pediatric Anesthesia - June 14, 2013 Category: Anesthesiology Authors: Amelia Pickard, Clinton Lobo, Peter A. Stoddart Tags: Case Report Source Type: research

Controlled rapid sequence induction and intubation – an analysis of 1001 children
ConclusionControlled RSII with gentle facemask ventilation prior to intubation supports stable cardiorespiratory conditions for securing the airway in children with an expected or suspected full stomach. Pulmonary aspiration does not seem to be significantly increased. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - June 14, 2013 Category: Anesthesiology Authors: Diego Neuhaus, Achim Schmitz, Andreas Gerber, Markus Weiss Tags: Original Article Source Type: research

MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells
Conclusion: Our results suggest that down-regulation of miR-204 promotes gastric cancer cell invasion by activating the SIRT1-LKB1 pathway. These data demonstrate that miR-204 plays an important role in regulating metastasis of gastric cancer, which is involved in post-transcriptional repression of SIRT1. (Source: BMC Cancer)
Source: BMC Cancer - June 14, 2013 Category: Cancer & Oncology Authors: Lihua ZhangXueqing WangPingsheng Chen Source Type: research

Methylnaltrexone for Opioid‐Induced Constipation in Pediatric Oncology Patients
ConclusionThis case series suggests that methylnaltrexone is safe and may be effective when given subcutaneously as a 0.15 mg/kg single dose to pediatric oncology patients with opioid‐induced constipation. Pediatr Blood Cancer 2013;9999:1–4. © 2013 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - June 14, 2013 Category: Cancer & Oncology Authors: Amelia Rodrigues, Cherie Wong, Andrea Mattiussi, Sarah Alexander, Elaine Lau, L. Lee Dupuis Tags: Research Article Source Type: research

Serum autoantibodies positivity prevalence in patients with chronic HCV and impact on pegylated interferon and ribavirin treatment response
ConclusionsANA positivity is not a factor in chronic HCV disease progression and does not affect the treatment response. Pegylated interferon and ribavirin therapy is safe and effective in autoantibodies‐positive chronic HCV patients with no need for further follow‐up or worry during the treatment in absence of systemic autoimmune disorders. (Source: Liver International)
Source: Liver International - June 14, 2013 Category: Gastroenterology Authors: Marwa Khairy, Maissa El‐Raziky, Wafaa El‐Akel, Mohamed S. Abdelbary, Hany Khatab, Badawy El‐Kholy, Gamal Esmat, Mahassen Mabrouk Tags: Viral Hepatitis Source Type: research

The hidden danger of endurance races: analgesic use among ultramarathon runners.
CONCLUSION: We found a high prevalence of analgesic medication use among ultramarathon runners. A third of runners were not aware of any adverse effects or dangers associated with analgesic consumption. Analgesic medication may have deleterious effects on the body and its performance. Pre-race education programmes may help increase awareness of effects, risks and appropriate use, and consumption. PMID: 23757646 [PubMed - in process] (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - June 13, 2013 Category: Sports Medicine Authors: Scheer BV, Valero Burgos E Tags: Br J Sports Med Source Type: research

Recovery of transverse strain in high-stress tendons following exercise.
This study evaluated the time course of recovery of transverse strain in the Achilles and patellar tendons following a bout of resistance exercise. METHODS: Seventeen healthy adults underwent sonographic examination of the right patellar (n=9) or Achilles (n=8) tendons immediately prior to and following 90 repetitions of weight-bearing exercise. Quadriceps and gastrocnemius exercise were performed against an effective resistance of 175% and 250% body weight, respectively. Sagittal tendon thickness was determined 20 mm from the tendon enthesis and transverse strain was repeatedly monitored over a 24 hour recovery period...
Source: British Journal of Sports Medicine - June 13, 2013 Category: Sports Medicine Authors: Wearing S, Locke S, Cook J, Purdam C, Smeathers J, Hooper S Tags: Br J Sports Med Source Type: research

High resistance shank muscle strength training changes foot behaviour during a sudden ankle supination.
CONCLUSIONS: After both, FPST and PD, the ankle joint complex is more mechanically stabilized against sudden supinations due to muscle volume increase. According to the typical ankle sprain mechanism (plantarflexed and supinated foot in a landing maneuver), a combination of dorsiflexor and specific pronator strength training might show even higher functional ankle stability. Future clinical studies might show the preventive potential of shank muscle training. PMID: 23757671 [PubMed - in process] (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - June 13, 2013 Category: Sports Medicine Authors: Hagen M, Lescher S, Hennig E, Felber S Tags: Br J Sports Med Source Type: research

Altered patterns of norovirus GII.b recombinant forms in gastroenteritis outbreaks in victoria, Australia, 2002–2005 compared to 2006–2011
Abstract GII.b norovirus is an obligatory recombinant with an open reading frame (ORF) 1 comprising the GII.b genotype and the ORF 2 region corresponding to one of a number of other norovirus genotypes. GII.b is the second most common genotype after GII.4 associated with gastroenteritis outbreaks in Victoria, Australia. The study involved norovirus testing of 14,186 specimens from 2,743 Victorian gastroenteritis outbreaks in the period 2002–2011. The noroviruses identified were further characterized by nucleotide sequencing and phylogenetic analysis. In the period 2002–2005, 21 GII.b norovirus outbreaks were identified...
Source: Journal of Medical Virology - June 13, 2013 Category: Virology Authors: L.D. Bruggink, J.A. Marshall Tags: Research Article Source Type: research

Full genomic characterization of a group C rotavirus isolated from a child in south Korea
Abstract During an epidemiological survey of human rotavirus infection in Seoul, Korea, from 2010 to 2011, one isolate of group C rotavirus (GCRV), named CAU10‐312, was detected in a 5‐year‐old child admitted to the hospital with acute gastroenteritis, and its complete genomic sequence was determined. The 11 gene segments of the strain possessed G4‐P[2]‐I2‐R2‐C2‐M2‐A2‐N2‐T2‐E2‐H2 genotypes. The genotype of strain CAU10‐312 appears to be closely related to strains from Bangladesh (DhakaC13 and BS347), India (v508), and England (Bristol), but distinct from Far East Asian strains, Chinese (Wu82 and...
Source: Journal of Medical Virology - June 13, 2013 Category: Virology Authors: In Hyuk Baek, Van Thai Than, Hakyoung Kim, Inseok Lim, Wonyong Kim Tags: Research Article Source Type: research

Preoperative SYNTAX score and graft patency after off-pump coronary bypass surgery [ADULT CARDIAC]
CONCLUSIONS The preoperative SYNTAX score and its individual components are not associated with graft occlusion after off-pump CABG. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Kinoshita, T., Asai, T., Suzuki, T. Tags: ADULT CARDIAC Source Type: research

Phenylephrine infusion improves blood flow to the stomach during oesophagectomy in the presence of a thoracic epidural analgesia [THORACIC]
CONCLUSIONS An intravenous phenylephrine infusion can reverse the epidural bolus-induced reduction in blood flow at the anastomotic end of the newly formed gastric tube. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Pathak, D., Pennefather, S. H., Russell, G. N., Al Rawi, O., Dave, I. C., Gilby, S., Page, R. D. Tags: THORACIC Source Type: research

Pulmonary aspiration in pediatric anesthetic practice in the UK: a prospective survey of specialist pediatric centers over a one‐year period
ConclusionsThis multicenter survey of specialist pediatric centers in the UK over a one‐year period reveals a low incidence of pulmonary aspiration in both elective and emergency cases. All patients made a full recovery. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - June 13, 2013 Category: Anesthesiology Authors: Robert W.M. Walker Tags: Original Article Source Type: research

A disease‐specific enteral nutrition formula improves nutritional status and functional performance in patients with head and neck and esophageal cancer undergoing chemoradiotherapy: Results of a randomized, controlled, multicenter trial
CONCLUSIONEnteral nutrition with EPA and DHA may be advantageous in patients with head and neck or esophageal cancer by improving parameters of nutritional and functional status during CRT. Cancer 2013. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - June 13, 2013 Category: Cancer & Oncology Authors: Rainer Fietkau, Victor Lewitzki, Thomas Kuhnt, Tobias Hölscher, Clemens‐F. Hess, Bernhard Berger, Thomas Wiegel, Claus Rödel, Marcus Niewald, Robert M. Hermann, Dorota Lubgan Tags: Original Article Source Type: research

Immune Infiltrates in GIST
Cancer immunosurveillance relies on effector/memory tumor-infiltrating CD8+ T cells with a T-helper cell 1 (TH1) profile. Evidence for a natural killer (NK) cell-based control of human malignancies is still largely missing. The KIT tyrosine kinase inhibitor imatinib mesylate markedly prolongs the survival of patients with gastrointestinal stromal tumors (GIST) by direct effects on tumor cells as well as by indirect immunostimulatory effects on T and NK cells. Here, we investigated the prognostic value of tumor-infiltrating lymphocytes (TIL) expressing CD3, Foxp3, or NKp46 (NCR1) in a cohort of patients with localized GIST....
Source: Cancer Research - June 13, 2013 Category: Cancer & Oncology Authors: Rusakiewicz, S., Semeraro, M., Sarabi, M., Desbois, M., Locher, C., Mendez, R., Vimond, N., Concha, A., Garrido, F., Isambert, N., Chaigneau, L., Le Brun–Ly, V., Dubreuil, P., Cremer, I., Caignard, A., Poirier–Colame, V., Chaba, K., Flament, C Tags: Clinical Studies Source Type: research