Gastroenterology Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

Postoperative recurrence of Crohn’s disease: impact of endoscopic monitoring and treatment step‐up
Conclusion Clinical recurrence occurs in a majority of patients soon after surgery. In this cohort, there was no clinical benefit from colonoscopy or increased drug therapy within 1 year after operation. However, the response to the endoscopic findings was not standardized and immunosuppressive therapy was uncommon. Standardizing timing of colonoscopy and drug therapy, including more intense therapy, may improve outcome, although this remains to be proven.
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: P. De Cruz, M.‐P. Bernardi, M. A. Kamm, P. B. Allen, L. Prideaux, J. Williams, M. J. Johnston, J. Keck, R. Brouwer, A. Heriot, R. Woods, S. Brown, S. J. Bell, R. Elliott, W. R. Connell, P. V. Desmond Tags: Original article Source Type: research

Does the incidence of unexpected malignancy in ‘benign’ rectal neoplasms undergoing trans‐anal endoscopic microsurgery vary according to lesion morphology?
Conclusion In this study exophytic polyps were less likely to be accurately classified as benign using preoperative ultrasonography/endoscopy when compared with flat‐sessile or mixed morphology polyps.
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: I. Dash, C. J. Walter, J. M. D. Wheeler, N. R. Borley Tags: Original article Source Type: research

Screen‐detected colorectal cancers show improved cancer‐specific survival when compared with cancers diagnosed via the 2‐week suspected colorectal cancer referral guidelines
Conclusion Screening for colorectal cancer identifies cancers at a significantly earlier stage than in symptomatic patients, with subsequent improvement in cancer‐specific survival.
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: E. D. Courtney, D. Chong, R. Tighe, J. R. Easterbrook, W. S. L. Stebbings, J. Hernon Tags: Original article Source Type: research

Management and short‐term outcome of malignant colorectal polyps in the north of England1
Conclusion Endoscopic management of a subgroup of MCPs appears safe. A clear resection margin (> 0 mm) appears sufficient to avoid surgery, except in locally advanced lesions (Kikuchi 3/Haggitt 4) which have a greater risk of residual cancer at surgery and lymph node metastasis.
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: M. D. Gill, M. D. Rutter, S. J. Holtham Tags: Original article Source Type: research

Comparison of long‐term survival outcome of operative vs nonoperative management of recurrent rectal cancer
Conclusion Most recurrences occur within 5 years of primary surgery, although some occur up to 10 years later. R0 resection is the treatment of choice. There was no survival benefit of R2 resection over nonresected recurrences.
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: A. Bhangu, S. M. Ali, D. Cunningham, G. Brown, P. Tekkis Tags: Original article Source Type: research

Surgery for recurrent rectal cancer: higher and wider?
Conclusion Awareness of the surgical options and a willingness to consider more aggressive options may result in more patients being considered for potentially curative resection.
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: D. P. Harji, B. Griffiths, D. R. McArthur, P. M. Sagar Tags: Systematic review Source Type: research

Advanced and recurrent rectal cancer
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: John Nicholls Tags: Editorial Source Type: research

Is colectomy for fulminant C. difficile colitis life saving? A systematic review
ConclusionEmergent colectomy for patients with FCDC provides a survival advantage compared with continuing antibiotics. Though there is selection bias of patients having surgery, the results of this systematic review suggest that colectomy has a therapeutic role in treating severe forms of C. difficile colitis.© 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: David B. Stewart, Christopher S. Hollenbeak, Matthew Z. Wilson Tags: Systematic Review Source Type: research

The prevalence of right‐sided colonic diverticulosis and diverticular haemorrhage
ConclusionThe prevalence of colonic diverticula increased from less than 10% in adults under 40 to about 75% in those over 75 years. Of these patients, nearly one third presented with right‐sided involvement. Right‐sided localization was associated with a significant risk of bleeding independent of the patients’ age.© 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: JL Faucheron, X Roblin, P Bichard, F Heluwaert Tags: Original Article Source Type: research

Colonic Electrical Stimulation: Potential Use for Treatment of Delayed Colon Transit
ConclusionCES with pulse trains has prokinetic effects on colonic contractions and transit in healthy dogs, mediated via the cholinergic and nitrergic pathways. Further clinical studies are warranted to explore the therapeutic potential of CES for slow colon transit constipation.© 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: Hanaa S. Sallam, Jiande DZ Chen Tags: Original Article Source Type: research

Computed tomography has low sensitivity for the diagnosis of early colon cancer
ConclusionCT scanning of colonic cancer showed 75% accuracy in identifying T1 and T2 cancers combined, but gave poor agreement between CT and histopathology for individual T stages.© 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland
Source: Colorectal Disease - January 25, 2013 Category: Gastroenterology Authors: I‐Ha Lao, Yen‐Jen Wang, Chee‐Wai Mak, Wen‐Sheng Tzeng, Reng‐Hong Wu, Sheng‐Tsung Chang, Jui‐Lung Fang Tags: Original Article Source Type: research

Adding Pancreatic Panniculitis to the Panel of Skin Lesions Associated with Triple Therapy of Chronic Hepatitis C
Dermatological side‐effects are a major concern in peginterferon (PegIFN)‐based treatments of hepatitis C virus (HCV) infection, with eczematous dermatitis, xerosis, generalized pruritus, and exacerbation of underlying skin disorders as prominent examples. The recent registration of the protease inhibitor telaprevir in combination with PegIFN and ribavirin (RBV) is expected to significantly increase the rate and severity of dermatological side‐effects by causing a rash in more than 50% of patients. Thus, early recognition of skin abnormalities will be crucial to assure their effective treatment, avoid premature cessa...
Source: Liver International - January 25, 2013 Category: Gastroenterology Authors: Nubio Pfaundler, Kerstin Kessebohm, Roland Blum, Marco Stieger, Felix Stickel Tags: Letter to the Editor Source Type: research

Liver stiffness measurement as alternative of fibrotic stage in risk assessment of hepatocellular carcinoma incidence for chronic hepatitis C patients
ConclusionAs an alternative of fibrosis stage, initial LSM is useful as a non‐invasive method in risk assessment of HCC occurrence for patients with chronic hepatitis C. Serial follow‐up LSM>12 kPa carries higher risk of HCC development.© 2013 John Wiley & Sons A/S
Source: Liver International - January 25, 2013 Category: Gastroenterology Authors: Hsin‐Ming Wang, Chao‐Hung Hung, Sheng‐Nan Lu, Chien‐Hung Chen, Chuan‐Mo Lee, Tsung‐Hui Hu, Jing‐Houng Wang Tags: Original Article Source Type: research

GLP‐1 analogue prevents NAFLD in ApoE KO mice with diet and Acrp30 knockdown by inhibiting c‐JNK
ConclusionsOur study also showed potent inhibitory effects of liraglutide on MKK4/JNK signaling which may be a mechanism for the observed improved insulin sensitivity and inflammatory stress induced by HFD and hypoadiponectinemia.© 2013 John Wiley & Sons A/S
Source: Liver International - January 25, 2013 Category: Gastroenterology Authors: Lili Zhang, Mengliu Yang, Hong Ren, H Huaidong, Guenther Boden, Li Ling, Yang Gangyi Tags: Original Article Source Type: research

Improvement in Liver Histology Among Asian Patients With Chronic Hepatitis B After Long‐term Treatment With Entecavir
Asian patients with chronic hepatitis B (CHB) have a higher risk of progressive liver disease than Caucasians patients and may show a different response to treatment due to both perinatal exposure and infection with hepatitis B virus (HBV) genotypes B or C (1). Long‐term entecavir (ETV) treatment resulted in potent antiviral suppression and histologic improvement in nucleoside‐naïve HBeAg(+) or HBeAg(–) CHB patients in Phase III trials and the roll‐over study ETV‐901 (2,3). A subgroup analysis demonstrated comparable virologic, biochemical, and serologic responses with long‐term ETV therapy between Asian patie...
Source: Liver International - January 25, 2013 Category: Gastroenterology Authors: Myron J. Tong, Kris V. Kowdley, Calvin Pan, Ke‐Qin Hu, Ting‐Tsung Chang, Kwang‐Hyub Han, Seung‐Kew Yoon, Zachary D. Goodman, Suzanne Beebe, Uchenna Iloeje, Hong Tang Tags: Letter to the Editor Source Type: research

Bouveret's Syndrome: a rare complication of gallstone disease
A 63‐year‐old female patient presented with epigastric pain and vomiting. Laboratory tests showed high levels of pancreatic enzymes, reaching six times the upper normal value, and normal liver function tests. An abdominal ultrasonography was performed, finding gallbladder stone filled. In the suspicion of acute pancreatitis, she was admitted and treated with bowel rest and intravenous hydration. CT scan showed no sign of pancreatitis while, surprisingly, a 3.2 cm gallstone with characteristic eggshell‐like calcification was seen in duodenum (Figure 1). © 2013 John Wiley & Sons A/S
Source: Liver International - January 25, 2013 Category: Gastroenterology Authors: Filippo Antonini, Valerio Belfiori, Giampiero Macarri Tags: Liver International Images Source Type: research

1, 25‐ dihydroxyvitamin D3 and its nuclear receptor represses human α1(I) collagen expression and type I collagen formation
Conclusions1,25‐(OH)2D3 inhibits type I collagen formation in human stellate cells. The effect of 1,25‐(OH)2D3 is mediated by its receptor which binds at a proximal Sp1.1 site and at a newly identified distal site on the collagen promoter. Correction of vitamin D deficiency in patients with chronic liver disease is a potential therapy to inhibit progression of fibrosis.© 2013 John Wiley & Sons A/S
Source: Liver International - January 25, 2013 Category: Gastroenterology Authors: James J. Potter, Xiaopu Liu, Ayman Koteish, Esteban Mezey Tags: Original Article Source Type: research

Patterns Of Appearance And Risk Of Misdiagnosis Of Intrahepatic Cholangiocarcinoma In Cirrhosis At Contrast Enhanced Ultrasound
ConclusionsCEUS misdiagnosed as HCC a significantly higher number of ICC lesions in cirrhotic patients than CT and MRI. However, some CEUS contrast features can help to suspect ICC, expecially in some cases with inconclusive CT or MRI.© 2013 John Wiley & Sons A/S
Source: Liver International - January 25, 2013 Category: Gastroenterology Authors: Marzia Galassi, Massimo Iavarone, Sandro Rossi, Simona Bota, Sara Vavassori, Laura Rosa, Simona Leoni, Laura Venerandi, Sara Marinelli, Angelo Sangiovanni, Letizia Veronese, Mirella Fraquelli, Alessandro Granito, Rita Golfieri, Massimo Colombo, Luigi Bolo Tags: Original Article Source Type: research

Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3‐kinase inhibitor BEZ235 and the PI3‐kinase inhibitor BKM120 in hepatocellular carcinoma
ConclusionsIn this study, BKM120 showed the strongest anti‐tumor activity. Our findings suggest impairment of mitochondrial function as a relevant mechanism of BKM120. Moreover, combination of PI3K and mTOR inhibitors with cytotoxic agents could be promising option for non‐cirrhotic HCC patients.© 2013 John Wiley & Sons A/S
Source: Liver International - January 25, 2013 Category: Gastroenterology Authors: Martha M. Kirstein, Aristeidis E. Boukouris, Deepika Pothiraju, Laura Elisa Buitrago‐Molina, Silke Marhenke, Jutta Lamlé, Johanna Orlik, Florian Kühnel, Jan Hegermann, Michael P. Manns, Arndt Vogel Tags: Original Article Source Type: research

The Natural History and Long‐term Outcomes in Patients with Chronic Hepatitis C Genotype 4 after Interferon‐based Therapy
ConclusionsThis study describes, for the first time, the natural history and demonstrates the beneficial long‐term effects of interferon‐based therapy in HCV G4 patients.© 2013 John Wiley & Sons A/S
Source: Liver International - January 25, 2013 Category: Gastroenterology Authors: F.Z. Alfaleh, K. Alswat, A. Helmy, W. Al‐hamoudi, M. El‐sharkawy, M. Omar, A. Shalaby, M.A. Bedewi, Q. Hadad, S. M Ali, A. Alfaleh, AA. Abdo Tags: Original Article Source Type: research

Cytomegalovirus duodenitis associated with acquired immunodeficiency syndrome
Source: Digestive Endoscopy - January 25, 2013 Category: Gastroenterology Authors: Shinya Sugimoto, Yukihiro Yoshimura, Hirokazu Komatsu Tags: Letters, Techniques and Images Source Type: research

Diagnosis of adrenocortical carcinoma via endosonography‐assisted fine‐needle aspiration of inferior vena cava thrombosis: First case in the literature
Source: Digestive Endoscopy - January 25, 2013 Category: Gastroenterology Authors: Gurhan Sisman, Yusuf Ziya Erzin, Hakan Senturk Tags: Letters, Techniques and Images Source Type: research

Edema of the interarytenoid mucosa seen on endoscopy is related to endoscopic‐positive esophagitis (EE) and is an independent predictor of EE
ConclusionsAlthough LPR symptoms had no significant relationship with the findings of EE, hiatal hernia and edema of the interarytenoid mucosa were significantly related with EE and were considered to be independent predictors of EE.
Source: Digestive Endoscopy - January 25, 2013 Category: Gastroenterology Authors: Yoshihiro Kondo, Naotaka Ogasawara, Makoto Sasaki, Mariko Arimoto, Kenichiro Yanamoto, Kunihiro Nishimura, Hisatsugu Noda, Noriko Okaniwa, Tetsuya Ogawa, Kunio Kasugai Tags: Original Article Source Type: research

Decreased core muscle size is associated with worse patient survival following esophagectomy for cancer
This study evaluated the relationship between core muscle size and patient outcomes following esophagectomy for malignancy. Using preoperative computed tomography scans in 230 subjects who had undergone transhiatal esophagectomy for cancer between 2001 and 2010, lean psoas area (LPA), measured at the fourth lumbar vertebra, was determined. Cox proportional hazards regression was employed to analyze overall survival (OS) and disease‐free survival (DFS) adjusted for age, gender, and stage, and the Akaike information criterion was used to determine each covariate contribution to OS and DFS. Univariate analysis demonstrated ...
Source: Diseases of the Esophagus - January 25, 2013 Category: Gastroenterology Authors: K. H. Sheetz, L. Zhao, S. A. Holcombe, S. C. Wang, R. M. Reddy, J. Lin, M. B. Orringer, A. C. Chang Tags: Original article Source Type: research

Ganglioside-monosialic acid (GM1) prevents oxaliplatin-induced peripheral neurotoxicity in patients with gastrointestinal tumors
In this study, 120 patients with gastrointestinal tumors were enrolled, andthey received the treatment of XELOX (oxaliplatin and capecitabine) and FOLFOX4 (oxaliplatin, leukovolin and 5-fluorouracil). The patients were randomly divided into two groups, the experimental group and control group, with60 patients ineach. On the day chemotherapy was initiated, the experimental group received GM1 intravenously (100 mg once daily) for 3 days, while no neuroprotective agents were applied in the control group. The incidence rates and classification of neurotoxicity in the two groups were evaluated and the differences between the tw...
Source: World Journal of Surgical Oncology - January 25, 2013 Category: Cancer & Oncology Authors: Yanyun ZhuJunlan YangShunchang JiaoTiefeng Ji Source Type: research

Association of anaemia in primary care patients with chronic kidney disease: cross sectional study of quality improvement in chronic kidney disease (QICKD) trial data
Background: Anaemia is a known risk factor for cardiovascular disease and treating anaemia in chronic kidney disease (CKD) may improve outcomes. However, little is known about the scope to improve primary care management of anaemia in CKD. Methods: An observational study (N = 1,099,292) with a nationally representative sample using anonymised routine primary care data from 127 Quality Improvement in CKD trial practices (ISRCTN5631023731). We explored variables associated with anaemia in CKD: eGFR, haemoglobin (Hb), mean corpuscular volume (MCV), iron status, cardiovascular comorbidities, and use of therapy which associated...
Source: BMC Nephrology - January 25, 2013 Category: Urology & Nephrology Authors: Olga DmitrievaSimon de LusignanIain MacdougallHugh GallagherCharles TomsonKevin HarrisTerry DesombreDavid Goldsmith Source Type: research

Systematic review and meta‐analysis of laparoscopic versus open colectomy with end ileostomy for non‐toxic colitis
Conclusion:Where the procedure can be completed laparoscopically, there may be short‐term benefits over open colectomy for colitis. These results cannot be generalized to critically ill patients in need of an emergency subtotal colectomy. Copyright © 2013 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Source: British Journal of Surgery - January 25, 2013 Category: Surgery Authors: S. A. L. Bartels, T. J. Gardenbroek, D. T. Ubbink, C. J. Buskens, P. J. Tanis, W. A. Bemelman Tags: Systematic review Source Type: research

Rapid and sensitive electrochemiluminescence detection of rotavirus by magnetic primer based reverse transcription-polymerase chain reaction.
In this study, rotavirus in fecal specimens was successfully detected within 1.5h. Experimental results showed that the detection limit of the assay was 0.2pgμL(-1) of rotavirus. The ECL intensity was linearly with the concentration from 0.2pgμL(-1) to 400pgμL(-1). What's more, the specificity of this method was confirmed by detecting other fecal specimens of patients with nonrotavirus-associated gastroenteritis. We anticipate that the proposed magnetic primer based RT-PCR with ECL detection strategy will find numerous applications in food safety field and clinical diagnosis. PMID: 23312316 [PubMed - in process]
Source: Analytica Chimica Acta - January 24, 2013 Category: Chemistry Authors: Zhan F, Zhou X, Xing D Tags: Anal Chim Acta Source Type: research

Patient Selection for Therapy Reduction after Long-Term Daily Proton Pump Inhibitor Treatment for Gastro-Oesophageal Reflux Disease: Trial and Error
Digestion 2013;87:85–90 (DOI:10.1159/000345144)
Source: Digestion - January 24, 2013 Category: Gastroenterology Source Type: research

Active Eosinophilic Esophagitis Is Associated with Impaired Elimination of Budesonide by Cytochrome P450 3A Enzymes
Digestion 2013;87:110–117 (DOI:10.1159/000346403)
Source: Digestion - January 24, 2013 Category: Gastroenterology Source Type: research

Crocin Triggers the Apoptosis Through Increasing the Bax/Bcl-2 Ratio and Caspase Activation in Human Gastric Adenocarcinoma, AGS, Cells
DNA and Cell Biology Feb 2013, Vol. 32, No. 2: 50-57.
Source: DNA and Cell Biology - January 24, 2013 Category: Cytology Tags: article Source Type: research

Nurse practitioner prescribing practices: the most frequently prescribed medications
ConclusionThe majority of nurse practitioners in Australia prescribe medications in their clinical practice, although the proportion of nurse practitioners prescribing has not changed significantly in the past four years. The medications prescribed are comparable with those most frequently prescribed by all prescribers in Australia and highlight the diversity in scope of practice among nurse practitioners. Relevance to clinical practiceFindings highlight the importance of Nurse Practitioner's a capacity to prescribe wide variety of medications, especially in practice areas such acute, primary and emergency care. The unique...
Source: Journal of Clinical Nursing - January 24, 2013 Category: Nursing Authors: Thomas Buckley, Andrew Cashin, Meg Stuart, Graeme Browne, Sandra V Dunn Tags: Original Article Source Type: research

Differential toxicity and gene expression in Caco-2 cells exposed to arsenic species.
Abstract Inorganic arsenic [As(V)+As(III)] and its metabolites, especially the trivalent forms [monomethylarsonous acid, MMA(III), and dimethylarsinous acid, DMA(III)], are considered the forms of arsenic with the highest degree of toxicity, linked to certain types of cancer and other pathologies. The gastrointestinal mucosa is exposed to these forms of arsenic, but it is not known what toxic effect these species may have on it. The aim of the present work was to evaluate the toxicity and some mechanisms of action of inorganic arsenic and its metabolites [monomethylarsonic acid, MMA(V), dimethylarsinic acid, DMA(V)...
Source: Toxicology Letters - January 24, 2013 Category: Toxicology Authors: Calatayud M, Devesa V, Vélez D Tags: Toxicol Lett Source Type: research

VP8(∗)P[8] lineages of group A rotaviruses circulating over 20years in Brazil: Proposal of six different sub-lineages for P[8]-3 clade.
Abstract Group A rotaviruses (RVA) is the most important cause of severe gastroenteritis among children worldwide. Vaccination is considered the best alternative among public health measures to reduce and prevent the global burden caused by RVA infections. Rotarix™, a monovalent vaccine based on a human strain with a G1P[8]-1 specificity, was introduced in the National Brazilian Immunization Programs (NIP) in March, 2006. RVA P[8] is the most prevalent P genotype worldwide and four distinct phylogenetic lineages: P[8]-1, -2, -3, and -4 have been described. In the current study phylogenetic analysis of the VP8(∗...
Source: Infection, Genetics and Evolution - January 24, 2013 Category: Genetics & Stem Cells Authors: da Silva MF, Gómez MM, Rose TL, Volotão ED, Carvalho-Costa FA, Bello G, Leite JP Tags: Infect Genet Evol Source Type: research

Education and Training in NOTES: A Systematic Review.
Conclusion. The development of a new specialty is intriguing but currently unviable. Training programs have been initiated, but information is limited; the common theme is surgeons receiving endoscopic training. Despite the research done, our knowledge of training and educating in NOTES procedures is limited, preventing a meta-analysis or formal review from being performed. Further research is needed to integrate NOTES into routine clinical procedure. PMID: 23355422 [PubMed - as supplied by publisher]
Source: Surgical Innovation - January 24, 2013 Category: Surgery Authors: Moghul MR, Sodergren MH, Clark J, Teare J, Yang GZ, Darzi A Tags: Surg Innov Source Type: research

[The Joint Annual Congress of "DGVS"/"DGAV" 2011 - Selected Topics Outlined by Organiser & Participant, Gastroenterologist & Abdominal Surgeon.]
[The Joint Annual Congress of "DGVS"/"DGAV" 2011 - Selected Topics Outlined by Organiser & Participant, Gastroenterologist & Abdominal Surgeon.] Zentralbl Chir. 2013 Jan 24; Authors: Bornschein J, Meyer F PMID: 23348230 [PubMed - as supplied by publisher]
Source: Zentralblatt fur Chirurgie - January 24, 2013 Category: Surgery Authors: Bornschein J, Meyer F Tags: Zentralbl Chir Source Type: research

Promotion of autoimmune diabetes by cereal diet in the presence or absence of microbes associated with gut immune activation, regulatory imbalance and altered cathelicidin antimicrobial peptide.
Abstract We are exposed to millions of microbial and dietary antigens via the gastrointestinal tract, which likely plays a key role in type 1 diabetes (T1D). We differentiated the effects of these two major environmental factors on gut immunity and T1D. Diabetes-prone BioBreeding (BBdp) rats were housed in specific pathogen-free (SPF) or germ-free (GF) conditions and weaned onto diabetespromoting cereal diets or a protective low antigen hydrolyzed casein (HC) diet and T1D incidence was monitored. Fecal microbiota 16S rRNA genes, immune cell distribution, and gene expression in jejunum were analyzed. T1D was highest...
Source: Diabetes - January 24, 2013 Category: Endocrinology Authors: Scott FW, Patrick C, Wang GS, Lefebvre DE, Crookshank JA, Sonier B, Eberhard CE, Mojibian M, Kennedy CR, Brooks SP, Kalmokoff ML, Maglio M, Troncone R, Poussier P Tags: Diabetes Source Type: research

Erratum to: Dobutamine, not dopamine, improves gastric intramucosal pH during resuscitation from hemorrhagic shock in dogs.
PMID: 23341166 [PubMed - as supplied by publisher]
Source: Canadian Journal of Anaesthesia - January 24, 2013 Category: Anesthesiology Authors: Hong SJ, Kim JB, Chon JY, Lee HJ, Sung CH, Moon SH Tags: Can J Anaesth Source Type: research

Inducible NOS Mediates CNP-induced Relaxation of Intestinal Myofibroblasts.
In this study we investigated the role of nitric oxide (NO) signaling in C-type natriuretic peptide (CNP)-induced relaxation of IMF. We found that treatment with ODQ, a soluble guanylyl cyclase (sGC) inhibitor, or L-NNA and L-NMMA, inhibitors of NO production, all impaired the relaxation of human and mouse IMF in response to CNP. ODQ, L-NNA and L-NMMA also prevented CNP-induced elevations in cGMP concentrations and L-NNA or L-NMMA blocked CNP-induced decreases myosin light phosphorylation. IMF isolated from transgenic mice deficient in inducible nitric oxide synthase (iNOS) had reduced relaxation responses to CNP compared ...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - January 24, 2013 Category: Physiology Authors: Chen Y, Chitapanarux T, Wu J, Soon RK, Melton AC, Yee HF Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

A prospective single‐centre evaluation of the intra‐individual variability of faecal calprotectin in quiescent Crohn's disease
ConclusionsDay to day variability of faecal calprotectin is low in our cohort of quiescent Crohn's disease patients and the reliability of defining a ‘case’ is moderately good. These data provide reassurance to clinicians using a single calprotectin sample to inform therapeutic strategies in this cohort.
Source: Alimentary Pharmacology and Therapeutics - January 24, 2013 Category: Drugs & Pharmacology Authors: G. D. Naismith, L. A. Smith, S. J. E. Barry, J. I. Munro, S. Laird, K. Rankin, A. J. Morris, J. W. Winter, D. R. Gaya Tags: Original Article Source Type: research

Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours
ConclusionsAmong uterine smooth muscle tumours, MED12 mutations are frequently present in conventional leiomyomas, but are significantly less common in histological variants of leiomyoma and leiomyosarcoma. In contrast to uterine lesions, none of the extrauterine smooth muscle tumours had MED12 mutations.
Source: Histopathology - January 24, 2013 Category: Pathology Authors: Akiko Matsubara, Shigeki Sekine, Masayuki Yoshida, Akihiko Yoshida, Hirokazu Taniguchi, Ryoji Kushima, Hitoshi Tsuda, Yae Kanai Tags: Short Report Source Type: research

Adipophilin/perilipin‐2 as a lipid droplet‐specific marker for metabolically active cells and diseases associated with metabolic dysregulation
ConclusionsAdipophilin immunohistochemistry visualizes small LDs in tissues under physiological and disease conditions that are not visible by conventional light microscopy. Immunohistology for adipophilin may facilitate histomorphological diagnosis of diseases and definition of the extent of metabolic dysregulation, such as in organ infarcts, cardiomyopathies, kidney diseases, and microvesicular steatosis.
Source: Histopathology - January 24, 2013 Category: Pathology Authors: Beate Katharina Straub, Benedek Gyoengyoesi, Maria Koenig, Merita Hashani, Lena Maria Pawella, Esther Herpel, Wolf Mueller, Stephan Macher‐Goeppinger, Hans Heid, Peter Schirmacher Tags: Original Article Source Type: research

Is there still a role for empiric first‐line triple therapy using proton pump inhibitor, amoxicillin and clarithromycin for Helicobacter pylori infection in Singapore? Results of a time trend analysis
ConclusionsFrom 2005 to 2010, there was no significant decrease in the efficacy of one‐week PPI/A/C for the treatment of H. pylori infection. This treatment regime remained an effective first‐line therapy for H. pylori infection in Singapore.
Source: Chinese Journal of Digestive Diseases - January 24, 2013 Category: Gastroenterology Authors: Tiing Leong Ang, Luokai Wang, Daphne Ang, Priscilla Chiam, Kwong Ming Fock, Eng Kiong Teo Tags: Original article Source Type: research

Effect of recombinant Lactobacillus casei expressing interleukin‐10 in dextran sulfate sodium‐induced colitis mice
ConclusionsRecombinant L. casei combined with 5‐ASA is effective in the treatment of DSS‐induced colitis. The possible mechanism might be the blocking of the excessive activation of NF‐κB pathway, thus suppressing the release of inflammation‐related factors.
Source: Chinese Journal of Digestive Diseases - January 24, 2013 Category: Gastroenterology Authors: Zhi Bing Qiu, Jian Chen, Jia Jie Chen, Lan Rong, Wei Qun Ding, Hai Jing Yang, Liang Zhong Tags: Original article Source Type: research

Utility of in vitro interferon‐γ release assay in differential diagnosis between intestinal tuberculosis and Crohn's disease
ConclusionT‐SPOT.TB is a valuable assay in differentiating ITB from CD, particularly in the diagnostic exclusion of ITB based on its high specificity and NPV.
Source: Chinese Journal of Digestive Diseases - January 24, 2013 Category: Gastroenterology Authors: Yuan Lei, Feng Ming Yi, Jie Zhao, Rishi Vishal Luckheeram, Sha Huang, Min Chen, Mei Fang Huang, Jin Li, Rui Zhou, Gui Fang Yang, Bing Xia Tags: Original article Source Type: research

S100A12: A noninvasive marker of inflammation in inflammatory bowel disease
This article reviews recent studies focusing on S100A12 and highlights the current and potential roles of this biomarker.
Source: Chinese Journal of Digestive Diseases - January 24, 2013 Category: Gastroenterology Authors: Floor Logt, Andrew S Day Tags: Invited review Source Type: research

Two‐step evolution of the hepatitis B drug‐resistant mutations in a patient who developed primary entecavir resistance
ConclusionIn this patient, pre‐existence of minor population of partially resistant viral strains and treatment non‐compliance probably contributed to his development of primary entecavir resistance.
Source: Liver International - January 24, 2013 Category: Gastroenterology Authors: Guan‐Huei Lee, Masafumi Inoue, Jimmy Kim‐Pern Toh, Roxanne Hui‐Heng Chong, Myat‐Oo Aung, Evelyn Siew‐Chuan Koay, Seng‐Gee Lim Tags: Original Article Source Type: research

Endoscopic resection (endoscopic mucosal resection/ endoscopic submucosal dissection) for early gastric cancer
Endoscopic resection of early gastric cancer is a well‐established standard therapy in Japan and Korea, and is increasingly used in other countries. Endoscopic resection should be curative for patients, and safe, easy and effective not only for patients, but also for endoscopists. Endoscopic submucosal dissection (ESD) is superior to standard endoscopic mucosal resection (EMR) as it is designed to provide en bloc R0 resection regardless of size and/or location. Correct pathological assessment of en bloc resected specimens is crucial for accurate diagnosis and patient stratification for the risk of metastasis. Outcome stu...
Source: Digestive Endoscopy - January 24, 2013 Category: Gastroenterology Authors: Takuji Gotoda, Hwoon‐Yong Jung Tags: Review Source Type: research

Role of antisecretory agents for gastric endoscopic submucosal dissection
Gastric endoscopic submucosal dissection (ESD) causes artificial gastric ulcers and there is no consensus regarding the optimal perioperative management in terms of prevention of intra‐ or postoperative bleeding and promotion of healing. Traditionally, 8‐week administration of proton pump inhibitors (PPI) and mucosal protective agents were used in the same way as for peptic ulcer management. However, recent studies have revealed that prior use of PPI might reduce intraoperative bleeding or early‐phase postoperative bleeding, and combination of histamine‐2 receptor antagonist (H2RA), and second‐look endoscopy migh...
Source: Digestive Endoscopy - January 24, 2013 Category: Gastroenterology Authors: Mitsuhiro Fujishiro, Philip WY Chiu, Hsui‐Po Wang Tags: Review Source Type: research