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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.

Response
We thank Ozaslan for his letter in which he speculates that the vulnerability of the papilla of Vater, with the complex microscopic mucosal features of its orifice and intrapapillary ducts, may explain the difficulties of papillary cannulation, a procedural technique associated with an increased risk for post-ERCP pancreatitis (PEP). He thinks that the anatomic features of the papillary mucosa may be the reason for similar trauma to the papilla by the guidewire and sphincterotome contrast medium injection technique, as confirmed by the similar numbers of cannulation attempts and the lack of a significant difference in the ...
Source: Gastrointestinal Endoscopy - January 14, 2013 Category: Gastroenterology Authors: Alberto Mariani, Antonella Giussani, Milena Di Leo, Sabrina Gloria Giulia Testoni, Pier Alberto Testoni Tags: Letters to the Editor Source Type: research

Difficult cannulation is the most important factor for post-ERCP pancreatitis: what is the mechanism?
I read with great interest the study by Mariani et al describing that guidewire biliary cannulation does not reduce post-ERCP pancreatitis (PEP) compared with the contrast injection technique in low-risk and high-risk patients. PEP occurred in 35 of 678 patients (5.2%) in the guidewire biliary cannulation group and 25 of 571 patients (4.4%) in the contrast injection group (not significant). In their study, the guidewire biliary cannulation technique did not prevent the trauma to the papilla more than the contrast injection technique, as confirmed by the similar number of cannulation attempts with the two techniques, a para...
Source: Gastrointestinal Endoscopy - January 14, 2013 Category: Gastroenterology Authors: Ersan Ozaslan Tags: Letters to the Editor Source Type: research

An endoclip for life?
A 48-year-old man with cirrhosis (Child score C) due to non-alcoholic steatohepatitis that was complicated by prior variceal bleeding presented to our institution with melena. The patient had gastric variceal bleeding 22 months before the current presentation, at which time he had an endoclip placed on the bleeding gastric varix before transfer to our institution (). At our hospital, he immediately underwent an upper endoscopy followed by transjugular intrahepatic portosystemic shunt (TIPS) placement. On this presentation, the patient was tachycardic, somnolent, and unable to answer any questions. He appeared jaundiced and...
Source: Gastrointestinal Endoscopy - January 14, 2013 Category: Gastroenterology Authors: Jana G. Hashash, Jaideep Behari Tags: At the Focal Point Source Type: research

Quality improvement for the gastroenterology fellow
Physicians are challenged every day to maximize health outcomes and minimize risk in a resource-limited environment. Yet, given the recent emphasis on increasing health care costs, we are compelled to provide even more efficient care—to deliver better quality care at lower costs. To do so successfully, there is a growing need for quality improvement in all of health care, including our field of gastroenterology. In this month's Fellows' Corner, Dr. Jeffrey J. Easler of the University of Pittsburgh provides an overview of quality improvement including its clinical importance, project implementation, and tangible ideas for...
Source: Gastrointestinal Endoscopy - January 14, 2013 Category: Gastroenterology Authors: Jeffrey J. Easler Tags: The Fellows' Corner Source Type: research

Continuing Medical Education Exam: February 2013
Source: Gastrointestinal Endoscopy - January 14, 2013 Category: Gastroenterology Authors: James Buxbaum, William Ross, Shou-Jiang Tang, Brian Weston, G.S. Raju, Glenn M. Eisen Tags: CME Examination Source Type: research

Suture marker lesion detection in the colon by self-stabilizing and unmodified capsule endoscopes: pilot study in acute canine models
Conclusion: The proposed self-stabilizing capsule endoscope delivered a significant improvement in detection rates of colon suture markings when compared with the unmodified capsule endoscope.
Source: Gastrointestinal Endoscopy - January 14, 2013 Category: Gastroenterology Authors: Dobromir Filip, Orly Yadid-Pecht, Gregory Muench, Martin P. Mintchev, Christopher N. Andrews Tags: Experimental Endoscopy Source Type: research

Development and validation of a nurse-assessed patient comfort score for colonoscopy
Conclusion: NAPCOMS is a reliable and valid tool for assessing patient comfort in the setting of outpatient colonoscopy performed with minimal to moderate sedation.
Source: Gastrointestinal Endoscopy - January 14, 2013 Category: Gastroenterology Authors: Alaa Rostom, Erin D. Ross, Catherine Dubé, Matthew D. Rutter, Thomas Lee, Roland Valori, Ronald J. Bridges, Darlene Pontifex, Veronica Webbink, Colin Rees, Carly Brown, Deborah H. Whetter, Susan G. Kelsey, Robert J. Hilsden Tags: Clinical Endoscopy Source Type: research

Spiral enteroscopy versus double-balloon enteroscopy: choosing the right tool for the job
The article in this journal by Messer et al comparing spiral enterosocopy (SE) with double-balloon enteroscopy (DBE) is a welcome addition to the knowledge base for the deep small-bowel endoscopist. The study is a prospective randomized study comparing both methods, and is a narrowly focused small study from a single center. The primary endpoint was complete small-bowel examination comparing peroral with anal enteroscopy by use of SE or DBE.
Source: Gastrointestinal Endoscopy - January 14, 2013 Category: Gastroenterology Authors: Paul A. Akerman Tags: Clinical Endoscopy Source Type: research

Is double-balloon enteroscopy superior to spiral enteroscopy?
The small intestine had long been considered uncharted territory for endoscopy outside the operating room until capsule endoscopy (CE) and double-balloon endoscopy (DBE) were developed early in the 21st century. CE enabled endoscopic imaging of the entire small intestine without patient discomfort. Although it is a technical breakthrough in the diagnosis of small-intestinal diseases, CE still does not offer targeted inspection of suspect areas or interventional capabilities such as biopsy or therapeutic maneuvers. DBE is the first endoscopic technique that allows reliably controlled deep enteroscopy without laparotomy. It ...
Source: Gastrointestinal Endoscopy - January 14, 2013 Category: Gastroenterology Authors: Hironori Yamamoto Tags: Clinical Endoscopy Source Type: research

Prophylactic main pancreatic duct stenting before precut biliary sphincterotomy: hold on to what you've got
Over the past decade, the placement of a temporary stent into the main pancreatic duct (PD) has evolved as the only effective, reproducible intervention that reduces the risk of post-ERCP pancreatitis (PEP) in high-risk cohorts. In this issue of Gastrointestinal Endoscopy, Cha and colleagues present data from a single-center prospective evaluation of 151 patients who underwent ERCP for biliary indications and subsequently required precut biliary access for failed cannulation. A main PD stent was successfully placed in 93 patients. After completion of the procedure, the patients were alternately allocated to leaving the PD ...
Source: Gastrointestinal Endoscopy - January 14, 2013 Category: Gastroenterology Authors: Barham K. Abu Dayyeh Tags: Clinical Endoscopy Source Type: research

Long-term outcomes of patients with Barrett's esophagus and high-grade dysplasia or early cancer treated with endoluminal therapies with intention to complete eradication
Conclusion: Multiple-mode endoluminal therapy for Barrett's esophagus with high-grade dysplasia or early cancer with intention to complete eradication of all intestinal metaplasia was successful, with low observed recurrence of dysplasia or cancer. However, recurrence of intestinal metaplasia occurs in one-third of cases and supports continued endoscopic surveillance even after complete eradication.
Source: Gastrointestinal Endoscopy - January 14, 2013 Category: Gastroenterology Authors: Carlos Guarner-Argente, Thomas Buoncristiano, Emma E. Furth, Gary W. Falk, Gregory G. Ginsberg Tags: Clinical Endoscopy Source Type: research

Multicentre results of stereotactic body radiotherapy for secondary liver tumours
ConclusionSecondary liver tumours treated with SBRT had a high rate of local control with a low incidence of adverse events.
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - January 14, 2013 Category: Gastroenterology Authors: Betul Berber, Rafael Ibarra, Laura Snyder, Min Yao, Jeffrey Fabien, Michael T. Milano, Alan W. Katz, Karyn Goodman, Kevin Stephans, Galal El‐Gazzaz, Federico Aucejo, Charles Miller, John Fung, Simon Lo, Mitchell Machtay, Juan Sanabria Tags: Original Article Source Type: research

Cutaneous manifestations of gastrointestinal disease: Part II
The gastrointestinal (GI) and cutaneous organ systems are closely linked. In part I of this continuing medical education article, the intricacies of this relationship were explored as they pertained to hereditary polyposis disorders, hamartomatous disorders, and paraneoplastic disease. Part II focuses on the cutaneous system's links to inflammatory bowel disease and vascular disorders. An in-depth analysis of inflammatory bowel disease skin findings is provided to aid dermatologists in recognizing and facilitating early consultation and intervention by gastroenterologists. Cutaneous signs of inflammatory bowel disease incl...
Source: Journal of the American Academy of Dermatology - January 14, 2013 Category: Dermatology Authors: Breck Thrash, Mahir Patel, Kejal R. Shah, C. Richard Boland, Alan Menter Tags: Continuing Medical Education Source Type: research

Cutaneous manifestations of gastrointestinal disease: Part I
Cutaneous findings are not uncommonly a concomitant finding in patients afflicted with gastrointestinal (GI) diseases. The dermatologic manifestations may precede clinically evident GI disease. Part I of this 2-part CME review focuses on dermatologic findings as they relate to hereditary and nonhereditary polyposis disorders and paraneoplastic disorders. A number of hereditary GI disorders have an increased risk of colorectal carcinomas. These disorders include familial adenomatous polyposis, Peutz–Jeghers syndrome, and juvenile polyposis syndrome. Each disease has its own cutaneous signature that aids dermatologists in ...
Source: Journal of the American Academy of Dermatology - January 14, 2013 Category: Dermatology Authors: Kejal R. Shah, C. Richard Boland, Mahir Patel, Breck Thrash, Alan Menter Tags: Continuing Medical Education Source Type: research

Concordance of ATM (Ataxia Telangiectasia Mutated) Immunohistochemistry between Biopsy or Metastatic Tumor Samples and Primary Tumors in Gastric Cancer Patients
Pathobiology 2013;80:127–137 (DOI:10.1159/000346034)
Source: Karger Publishers - January 14, 2013 Category: Cancer & Oncology Source Type: research

Mortal hyperkalemia disturbances in rats are NO-system related. The life saving effect of pentadecapeptide BPC 157.
Abstract We demonstrate the full counteracting ability of stable gastric pentadecapeptide BPC 157 against KCl-overdose (intraperitoneal (i), intragastric (ii), in vitro (iii)), NO-system related. (i) We demonstrated potential (/kg) of: BPC 157 (10ng, 10μg ip, complete counteraction), L-arginine (100mg ip, attenuation) vs. L-NAME (5mg ip, deadly aggravation), given alone and/or combined, before or after intraperitoneal KCl-solution application (9mEq/kg). Therapy was confronted with promptly unrelenting hyperkalemia (>12mmol/L), arrhythmias (and muscular weakness, hypertension, low pressure in lower esophageal an...
Source: Regulatory Peptides - January 14, 2013 Category: Biochemistry Authors: Barisic I, Balenovic D, Klicek R, Radic B, Nikitovic B, Drmic D, Udovicic M, Strinic D, Bardak D, Berkopic L, Djuzel V, Sever M, Cvjetko I, Romic Z, Sindic A, Seiwerth S, Sikiric P Tags: Regul Pept Source Type: research

Relationship between urinary fractional excretion of sodium and life prognosis in liver cirrhosis patients
ConclusionLevels of FENa may reflect LC severity and may be associated with the life prognosis of LC patients.
Source: Hepatology Research - January 14, 2013 Category: Internal Medicine Authors: Naro Ohashi, Naoko Tsuji, Yoshitaka Naito, Takamasa Iwakura, Shinsuke Isobe, Masafumi Ono, Tomoyuki Fujikura, Takayuki Tsuji, Yukitoshi Sakao, Hideo Yasuda, Kinya Kawamura, Takanori Sakaguchi, Akihiko Kato, Yoshihide Fujigaki Tags: Original Article Source Type: research

Premature death of TDP‐43 (A315T) transgenic mice due to gastrointestinal complications prior to development of full neurological symptoms of amyotrophic lateral sclerosis
Summary Abnormal distribution, modification and aggregation of transactivation response DNA‐binding protein 43 (TDP‐43) are the hallmarks of multiple neurodegenerative diseases, especially frontotemporal lobar degeneration with ubiquitin‐positive inclusions (FTLD‐U) and amyotrophic lateral sclerosis (ALS). Transgenic mouse lines overexpressing wild‐type or mutant TDP‐43 exhibit ALS‐like symptom, motor abnormalities and early paralysis followed by death. Reports on lifespan and phenotypic behaviour in Prp‐TDP‐43 (A315T) vary, and these animals are not fully characterized. Although it has been proposed that...
Source: International Journal of Experimental Pathology - January 14, 2013 Category: Pathology Authors: Mohammad A. Esmaeili, Marzieh Panahi, Shilpi Yadav, Leah Hennings, Mahmoud Kiaei Tags: Original Article Source Type: research

Lymphangiogenesis and Prognostic Significance of Vascular Endothelial Growth Factor C in Gastro‐oesophageal Junction Adenocarcinoma
Summary Vascular endothelial growth factor C (VEGF‐C) is a crucial regulator of the development of lymphatic vessels and is involved in the lymph node metastasis of cancer. The levels of VEGF‐C expression and lymphatic vessel density (LVD) in 128 gastro‐oesophageal junction adenocarcinoma (GEJA) tissues were examined by immunohistochemistry and analysed for their association with clinicopathological features and disease‐free survival. We found that 75.0% of tumour samples displayed strong immunoreactivity to VEGF‐C. The levels of VEGF‐C expression in the tumour tissues were associated with the stages of the cli...
Source: International Journal of Experimental Pathology - January 14, 2013 Category: Pathology Authors: Liang‐Xi Xie, Tian‐Tian Zhai, Li‐Ping Yang, Eleanor Yang, Xiao‐Hui Zhang, Jiong‐Yu Chen, Hao Zhang Tags: Original Article Source Type: research

Predictive biomarkers for Barrett's esophagus: so near and yet so far
Summary Barrett's esophagus (BE) is the strongest risk factor for the development of esophageal adenocarcinoma. However, the risk of cancer progression is difficult to ascertain in individuals, as a significant number of patients with BE do not necessarily progress to esophageal adenocarcinoma. There are several issues with the current strategy of using dysplasia as a marker of disease progression. It is subject to sampling error during biopsy acquisition and interobserver variability among gastrointestinal pathologists. Ideal biomarkers with high sensitivity and specificity are needed to accurately detect high‐risk BE p...
Source: Diseases of the Esophagus - January 14, 2013 Category: Gastroenterology Authors: M. R. Timmer, G. Sun, E. C. Gorospe, C. L. Leggett, L. Lutzke, K. K. Krishnadath, K. K. Wang Tags: Review article Source Type: research

Relation of excess body weight and survival in patients with esophageal adenocarcinoma: a meta‐analysis
In this study, a meta‐analysis was performed by searching PubMed, Cochrane Library, EMBASE, and Science Direct databases from 1960 to June 2012. Data were extracted from studies comparing survival in obese (body mass index >30), overweight (body mass index 25–29), and normal‐weight (body mass index 20–24) patients undergoing esophagectomy. A total of six studies with 1988 cases were suitable for this global meta‐analysis. Compared with patients of normal weight, the hazard ratio of postoperational survival for overweight and obese patients was 0.79 (95% confidence interval 0.65–0.95, P = 0.108) and 0.80 ...
Source: Diseases of the Esophagus - January 14, 2013 Category: Gastroenterology Authors: L. Hong, H. Zhang, Q. Zhao, Y. Han, J. Yang, L. Brain Tags: Original article Source Type: research

A retrospective study of different treatments of limited‐stage small‐cell esophageal carcinoma and associated prognostic factor analysis
This study retrospectively analyzed the outcomes of different treatments and prognostic factors that influence overall survival in patients with limited‐stage SCEC. The study included 106 patients pathologically diagnosed with limited‐stage SCEC at Huai'an First People's Hospital, Nanjing Medical University (Huai'an, China), between 1998 and 2007. There were 66 males and 40 females, with a median age of 58 years (range: 45–77 years). Fourteen patients received surgery alone, 42 received surgery and postoperative chemotherapy, 11 received radiotherapy alone, and 39 received concurrent chemoradiotherapy. Combined modal...
Source: Diseases of the Esophagus - January 14, 2013 Category: Gastroenterology Authors: J. Ding, J. Ji, W. Zhu, K. Zhou, J. Han, Y. Zhang, C. Yu, T. Li, G. Tao, F. Ji, X. Zhou, P. Pan Tags: Review article Source Type: research

Amplification of the telomerase RNA component gene as a new genetic marker for disease progression and prognosis in esophageal squamous cell carcinoma
Summary Amplification of the human telomerase RNA component (TERC) gene was found in esophageal squamous cell carcinoma (ESCC). However, its roles in the progression and prognosis of ESCC have not been well understood. The amplification of TERC in normal mucosa, low‐grade and high‐grade intraepithelial neoplasia, and invasive ESCC samples were evaluated using a fluorescence in situ hybridization assay. The amplification of TERC invariably occurred in high‐grade intraepithelial neoplasia and invasive ESCC, partially occurred in low‐grade intraepithelial neoplasia specimens, and seldom occurred in normal mucosa. The ...
Source: Diseases of the Esophagus - January 14, 2013 Category: Gastroenterology Authors: J.‐D. Wang, J. Ma, F.‐Y. Wang, L.‐B. Peng, X. Wang, S.‐S. Shi, H.‐H. Ma, Z.‐F. Lu, G.‐M. Lu, X.‐J. Zhou Tags: Original article Source Type: research

Esophageal small‐cell cancer: study of a rare disease
Summary Optimal treatment of esophageal small‐cell cancer, a rare disease, lacks consensus. Based on its lung small‐cell cancer analog, we hypothesized that chemotherapy with adjuvant radiotherapy would be optimal. This hypothesis was tested by studying the collective published literature. A meta‐analysis of individual patients from 148 articles (1952–2010) explored treatment and outcome of 577 patients with esophageal small‐cell cancer. Hazard function frailty modeling identified optimum therapy after accounting for article‐level and patient‐level heterogeneity. Fifty‐nine percent of publications reported ...
Source: Diseases of the Esophagus - January 14, 2013 Category: Gastroenterology Authors: S. Raja, T. W. Rice, J. Rajeswaran, J. Zhong, E. H. Blackstone Tags: Original article Source Type: research

Pyruvate kinase M2 is highly correlated with the differentiation and the prognosis of esophageal squamous cell cancer
Summary It's frequently stated that the pyruvate kinase M2 (PKM2) and Warburg effect are important for cancer development by accumulating more raw materials for macromolecule biosynthesis. However, the correlation between PKM2 and cancer is poorly reported. Here, we investigated the PKM2 expression in esophageal squamous cell cancer (ESCC). We observed that the expression of PKM2 was much higher in ESCC than in control normal tissue, and it is highly associated with many clinical features and prognosis. Specially, we found that the expression of PKM2 was closely related to the differentiation state of ESCC, and we further ...
Source: Diseases of the Esophagus - January 14, 2013 Category: Gastroenterology Authors: C. Zhan, Y. Shi, C. Lu, Q. Wang Tags: Original article Source Type: research

The impact of E‐cadherin expression on the prognosis of esophageal cancer: a meta‐analysis
Summary E‐cadherin is a 120‐KD transmembrane calcium‐dependent cell adhesion protein that has been demonstrated drownregulated in a large amount of invasive tumors. However, its effect on the prognosis of esophageal cancer (EC) remains controversial. All the relevant English articles that reported survival data or clinicopathological parameters were enrolled in this meta‐analysis. A total of 24 studies, including 2691 cases, were included in this study. Twelve studies containing 1669 cases were enrolled to synthesize with hazard ratio (HR) and its 95% confidence interval (CI). The pooled HR for all 12 studies enrol...
Source: Diseases of the Esophagus - January 14, 2013 Category: Gastroenterology Authors: X‐L. Xu, Z Q. Ling, S‐Z. Chen, B. Li, W‐H. Ji, W‐M. Mao Tags: Original article Source Type: research

Comparative Evaluation of 29 Commercial Helicobacter pylori Serological Kits
ConclusionThese data should help the users to choose the kit the most appropriate to their goals.
Source: Helicobacter - January 14, 2013 Category: Gastroenterology Authors: Christophe Burucoa, Jean‐Charles Delchier, Anne Courillon‐Mallet, Jean‐Dominique Korwin, Francis Mégraud, Frank Zerbib, Josette Raymond, Jean‐Louis Fauchère Tags: Original Article Source Type: research

Diabetes mellitus impacts risk of macrovascular invasion in patients undergoing transplantation for hepatocellular carcinoma
Conclusions: DM is associated with macrovascular invasion among a cohort of transplanted HCC patients.
Source: BMC Gastroenterology - January 14, 2013 Category: Gastroenterology Authors: Gregory ConnollySaman SafadjouRandeep KashyapRui ChenMark OrloffAram Hezel Source Type: research

Mountain laurel toxicosis in a dog
This report details a case of mountain laurel toxicosis in a dog, including management strategies and outcome, which has not been previously published in the veterinary literature.
Source: Journal of Veterinary Emergency and Critical Care - January 14, 2013 Category: Veterinary Research Authors: Ingrid O. Manhart, Camille DeClementi, Christine L. Guenther Tags: Case Report Source Type: research

Kinetics and prediction of HBsAg loss during therapy with analogues in patients affected by chronic hepatitis B HBeAg negative and genotype D
ConclusionsHBeAg negative patients infected by HBV genotype D should be treated with more potent NAs such as entecavir or tenofovir to obtain a significant qHBsAg decrease, but the achievement of HBsAg loss seems to require almost two decades of therapy.
Source: Liver International - January 14, 2013 Category: Gastroenterology Authors: Lucio Boglione, Antonio D'Avolio, Giuseppe Cariti, Gabriella Gregori, Elisa Burdino, Lorena Baietto, Jessica Cusato, Valeria Ghisetti, Francesco Giuseppe De Rosa, Giovanni Di Perri Tags: Original Article Source Type: research

Evaluation of a new fluorescence quantitative PCR test for diagnosing Helicobacter pylori infection in children
Background: Numerous diagnostic tests are available to detect Helicobactor pylori (H. pylori). There has been no single test available to detect H. pylori infection reliably. We evaluated the accuracy of a new fluorescence quantitative PCR (fqPCR) for H. pylori detection in children. Methods: Gastric biopsy specimens from 138 children with gastritis were sent for routine histology exam, rapid urease test (RUT) and fqPCR. 13C-urea breath test (13C-UBT) was carried out prior to endoscopic procedure. Gastric fluids and dental plaques were also collected for fqPCR analysis. Results: 38 children (27.5%) were considered positive...
Source: BMC Gastroenterology - January 14, 2013 Category: Gastroenterology Authors: Zhiying OuLiya XiongDing-You LiLanlan GengLixia LiPeiyu ChenMin YangYongmei ZengZhenwen ZhouHuimin XiaSitang Gong Source Type: research

Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice
Conclusions: Deficiency of FHL2 results in aggravation of murine liver fibrosis. In human liver samples, FHL2 is expressed in activated HSCs and portal fibroblasts in human fibrotic livers, pointing to a central role of FHL2 for human hepatic fibrogenesis as well.
Source: BMC Gastroenterology - January 14, 2013 Category: Gastroenterology Authors: Sebastian HussChristian StellmacherDiane GoltzInna KhlistunovaAlexander AdamJonel TrebickaJutta KirfelReinhard BüttnerRalf Weiskirchen Source Type: research

Redefining the R1 resection for pancreatic ductal adenocarcinoma: tumour lymph nodal burden and lymph node ratio are the only prognostic factors associated with survival
ConclusionLNB and LNR are the only prognostic factors for CSS in patients with pancreatic head adenocarcinoma, but do not predict recurrence. Microscopic RMs does not seem to influence the outcome even when redefined. Further prospective studies are indicated to substantiate these findings.
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - January 14, 2013 Category: Gastroenterology Authors: Biku J. John, Prashant Naik, Adrian Ironside, Brian R. Davidson, Guiseppe Fusai, Roopinder Gillmore, Jennifer Watkins, Sakhawat H. Rahman Tags: Original Article Source Type: research

The frequency of true short oesophagus in type II-IV hiatal hernia [THORACIC]
CONCLUSIONS True short oesophagus is present in 57% of type III–IV and in none of type II HHs. The intraoperative measurement of the submerged intra-abdominal oesophagus is an objective method for recognizing these patients. ClinicalTrials.gov ID NCT01587859. https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S0003J7U&selectaction=View&uid=U0000GED&ts=4&cx=uweuc0.
Source: European Journal of Cardio-Thoracic Surgery - January 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Lugaresi, M., Mattioli, S., Aramini, B., D'Ovidio, F., Di Simone, M. P., Perrone, O. Tags: THORACIC Source Type: research

Signet-Ring-Cell Carcinoma of Stomach Metastatic to the Bladder: A Case Report With Cytological and Histological Correlation and Literature Review
Conclusion. Bladder involvement by a secondary tumor is very rare, and a SRC carcinoma metastatic to the bladder, albeit extremely rare, should be considered in the differential diagnosis.
Source: International Journal of Surgical Pathology - January 13, 2013 Category: Pathology Authors: Vigliar, E., Marino, G., Matano, E., Imbimbo, C., Rossella, D. C., Insabato, L. Tags: Case Reports Source Type: research

Multinodular Reticular Schwannoma in the Head and Neck Region: A Potential Diagnostic Pitfall
This report describes a case occurring in the masticator space, accompanied by focal erosion of the orbital floor, clinically and radiologically worrisome for malignancy. The 26-year-old man presented with facial swelling for 3 month. The tumor shows a multinodular appearance, with dense lymphoplasmacytic infiltrates in the fibrous septa. The tumor nodules are composed of plump spindle cells disposed in a reticular pattern. The diagnosis is confirmed by strong positive staining for S100 protein. The differential diagnoses of reticular schwannoma in the soft tissues of head and neck region are different from those in the ga...
Source: International Journal of Surgical Pathology - January 13, 2013 Category: Pathology Authors: Lau, P. P. L., Yau, D. T. W., Lau, W. H., Mak, L. S., Chan, J. K. C. Tags: Case Reports Source Type: research

Mixed Gastric Carcinoma With Intestinal and Cribriform Patterns: A Distinctive Pathologic Appearance Associated With Poor Prognosis in Advanced Stages and a Potential Mimicker of Metastatic Breast Carcinoma
This article describes a peculiar pattern of gastric adenocarcinoma, previously unreported, that combines intestinal type adenocarcinoma with areas of cribriform pattern that resembles both architectural and cytological in situ ductal carcinoma of the breast and to the best of the authors’ knowledge, there are no earlier reports of this pattern in the stomach, which has been named "gastric carcinoma with cribriform component (CGA). The authors analyzed 12 cases of intestinal type adenocarcinoma with areas at least 20% of cribriform pattern (range from 20% to 90%) that was present in 9% of intestinal type gastric aden...
Source: International Journal of Surgical Pathology - January 13, 2013 Category: Pathology Authors: Lino-Silva, L. S., Salcedo Hernandez, R. A., Molina-Frias, E. Tags: Original Articles Source Type: research

CDK-associated Cullin 1 can promote cell proliferation and inhibit cisplatin-induced apoptosis in the AGS gastric cancer cell line
Conclusions: CAC1 can promote cell proliferation in the AGS gastric cancer cell line. Moreover, it can prevent AGS cells from experiencing cisplatin-induced apoptosis via modulating expressions of P53, BCL2 and BAX.
Source: World Journal of Surgical Oncology - January 13, 2013 Category: Cancer & Oncology Authors: Qi ZhengLing-Yu ZhaoYing KongKe-Jun NanYu YaoZi-Jun Liao Source Type: research

Differences in direct pharmacologic effects and antioxidative properties of mature breast milk and infant formulas
Conclusions: Human milk exerts direct pharmacologic relaxation effects and provides better antioxidant protection compared with infant formulas because of the presence of specific enzymatic components, such as human superoxide dismutase. We propose that these effects should be advantageous to an infant's gastrointestinal tract by supporting the normal work of the smooth musculature and maintaining redox homeostasis and may represent one of the mechanisms by which breast-feeding benefits health.
Source: Nutrition - January 12, 2013 Category: Nutrition Authors: Nikoleta Lugonja, Snežana D. Spasić, Olga Laugier, Aleksandra Nikolić-Kokić, Ivan Spasojević, Zorana Oreščanin-Dušić, Miroslav M. Vrvić Tags: Applied Nutritional Investigations Source Type: research

Utility of transient elastography in the non‐invasive evaluation of cystic fibrosis liver disease
ConclusionsLSM is an accurate and reliable non‐invasive tool in assessing CFLD and PHT. An LSM ≥6.8 kPa is highly suggestive of CFLD and an LSM <8.9 kPa reliably excludes PHT.© 2013 John Wiley & Sons A/S
Source: Liver International - January 12, 2013 Category: Gastroenterology Authors: Matthew T Kitson, William W Kemp, David M Iser, Eldho Paul, John W Wilson, Stuart K Roberts Tags: Original Article Source Type: research

Do Type VI Secretion Systems Translocate More Than Proteins?
Source: Helicobacter - January 12, 2013 Category: Gastroenterology Authors: Nadeem O. Kaakoush, Hazel M. Mitchell Tags: Letter to the Editor Source Type: research

Non‐Fatal Suicidal Self‐Poisonings in Children and Adolescents over a 5‐Year Period (2007‐2011)
The objective of this study was to analyse non‐fatal suicidal self‐poisonings in children and adolescents and to identify commonalities that might direct preventive health efforts. From the database of the Czech Toxicological Information Center, the inquiries due to non‐fatal suicidal self‐poisonings in children (9‐13 years old) and adolescents (14‐18 years old) in 2007–2011 were evaluated. From 10,492 calls about suicide attempts, 2,393 concerned children and adolescents (13.5% and 86.5%, respectively). Most suicide attempts were committed during the spring (31.3%). Among toxic agents, drugs were used in 97....
Source: Basic and Clinical Pharmacology and Toxicology - January 12, 2013 Category: Drugs & Pharmacology Authors: Sergey Zakharov, Tomas Navratil, Daniela Pelclova Tags: Original Article Source Type: research

Orlistat: Gastrointestinal effects: case report
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Differences in the treatment of young gastric cancer patients: Patients under 50 years have better 5-year survival than older patients.
Conclusions: Younger patients can be operated on with greater confidence as they have a significantly lower hospital mortality rate. They exhibit markedly better 5-year survival at all tumor stages. According to our data, there is nothing to support the general belief that young patients have a poorer disease course. Further clinical and experimental studies are necessary to investigate this group more precisely. PMID: 23314560 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - January 12, 2013 Category: Biomedical Science Authors: Schildberg C, Croner R, Schellerer V, Haupt W, Schildberg F, Schildberg M, Hohenberger W, Horbach T Tags: Adv Med Sci Source Type: research

Different effects of subchronic exposure to low concentrations of the organophosphate insecticide chlorpyrifos in a freshwater gastropod.
Abstract Chlorpyrifos is an organophosphate insecticide used for pest control on a number of food crops in many parts of the world. In recent years, there has been an important decrease in the number of organisms of Planorbarius corneus. Since the presence of pesticides in the water can be one of the reasons for this decrease, it is very important to study the effect of subchronic exposure to environmental concentrations of pesticides on these organisms. The aim of the present work was to investigate different effects of the subchronic exposure to low concentrations of the organophosphate chlorpyrifos in P. corneus...
Source: Ecotoxicology and Environmental Safety - January 12, 2013 Category: Environmental Health Authors: Rivadeneira PR, Agrelo M, Otero S, Kristoff G Tags: Ecotoxicol Environ Saf Source Type: research

Neuronal Galectin‐4 is required for axon growth and for the organization of axonal membrane L1 delivery and clustering
We describe here that galectin‐4 (Gal‐4), a lectin highly expressed in gastrointestinal tissues and involved in epithelial glycoprotein transport, is expressed by hippocampal and cortical neurons where it is sorted to discrete segments of the axonal membrane in a microtubule‐ and sulfatide‐dependent manner. Gal‐4 knockdown retards axon growth, an effect that can be rescued by recombinant Gal‐4 addition. This Gal‐4 reduction, as inhibition of sulfatide synthesis does, lowers the presence and clustered organization of axon growth‐promoting molecule NCAM L1 at the axon membrane. Furthermore, we find that Gal�...
Source: Journal of Neurochemistry - January 12, 2013 Category: Neurology Authors: Silvia Velasco, Natalia Díez‐Revuelta, Teresa Hernández‐Iglesias, Herbert Kaltner, Sabine André, Hans‐Joachim Gabius, José Abad‐Rodríguez Tags: Original Article Source Type: research

Derangements of liver tissue bioenergetics in Concanavalin A-induced hepatitis
This study aimed to investigate hepatocyte bioenergetics in this well-studied hepatitis model. Methods: C57Bl/6 and C57Bl/6 IFN-gamma-/- mice were injected intravenously with 12 mg ConA/kg. Liver specimens were collected at various timepoints after injection and analyzed for cellular respiration and caspase activation. Serum was analyzed for interferon-gamma (IFN-gamma) and aminotransferases. Fluorescence activated cell sorting analysis was used to determine the phenotype of infiltrating cells, and light and electron microscopy were used to monitor morphological changes. Phosphorescence analyzer that measured dissolved O2 ...
Source: BMC Gastroenterology - January 12, 2013 Category: Gastroenterology Authors: Mariam Al-ShamsiAllen ShahinEric Mensah-BrownAbdul-Kader Souid Source Type: research

The ART of decision making: Retreatment with TACE in patients with hepatocellular carcinoma
Conclusion An ART‐score of ≥2.5 prior the second TACE identifies patients with dismal prognosis who may not profit from further TACE sessions. (HEPATOLOGY 2013.)
Source: Hepatology - January 12, 2013 Category: Internal Medicine Authors: Wolfgang Sieghart, Florian Hucke, Matthias Pinter, Ivo Graziadei, Wolfgang Vogel, Christian Müller, Harald Heinzl, Michael Trauner, Markus Peck‐Radosavljevic Tags: Hepatobiliary Malignancies Source Type: research

Reducing interruptions to continuous enteral nutrition in the intensive care unit: a comparative study
ConclusionTargeted strategies to enteral feeding practice resulted in a reduction to the number of interruptions but not the duration of enteral nutrition lost to interruption. Reducing unnecessary interruption of feeding circuits is likely to minimise the risk for splash injury and contamination of feeding sets through less manipulation and interruption to enteral nutrition flow. Relevance to clinical practiceReview of practice may reveal opportunities for improvement. Nurse champions can facilitate change processes to improve care.
Source: Journal of Clinical Nursing - January 12, 2013 Category: Nursing Authors: Teresa A Williams, Gavin D Leslie, Tim Leen, Lauren Mills, Geoff J Dobb Tags: Original Article Source Type: research

Effects of Antiviral Therapy on Hepatitis B Virus Reactivation and Liver Function after Resection or Chemoembolization for Hepatocellular Carcinoma
ConclusionsHBV reactivation can occur after hepatectomy or TACE. Anti‐HBV therapy can reduce the risk of reactivation, thus reducing the risk of liver failure especially in patients undergoing TACE.© 2013 John Wiley & Sons A/S
Source: Liver International - January 12, 2013 Category: Gastroenterology Authors: Xiang‐Ming Lao, Guangyu Luo, Liang‐Tao Ye, Cheng Luo, Ming Shi, Dian Wang, Rongping Guo, Minshan Chen, Shengping Li, Xiaojun Lin, Yunfei Yuan Tags: Original Article Source Type: research