Gastroenterology
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. 
Subscribe to this data using MyMedWorm.
Subscribe to this data using GoogleReader.
Subscribe to this data using Bloglines.
Subscribe to this data using MyYahoo.
Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated hourly from thousands of authoritative health and news sources.
This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 15.
Antiviral Resistance and Specifically Targeted Therapy for HCV (STAT-C)
Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
This article focuses on the current literature concerning resistance and directly acting antiviral agents and identifies key challenges facing the treatment of chronic hepatitis C infection. Journal of Viral Hepatitis
Source: Medscape Gastroenterology Headlines - October 22, 2009 Category: Gastroenterology Tags: Gastroenterology Source Type: info
[A Case of Caroli Disease with Biliary Stones.]Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
No abstract availble.
PMID: 19844138 [PubMed - as supplied by publisher]
Source: Korean J Gastroenter... - October 22, 2009 Category: Gastroenterology Authors: Cha BH, Lee SH, Hwang JH, Kim SY, Kim HY Tags: Korean J Gastroenterol Source Type: journals
Subconjunctival HemorrhageEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Title: Subconjunctival HemorrhageCategory: Diseases and ConditionsCreated: 10/22/2009 12:10:00 PMLast Editorial Review: 10/22/2009 12:10:06 PM
Source: MedicineNet Crohn's Disease General - October 22, 2009 Category: Gastroenterology Source Type: consumer
Worldwide Vaccine Availability Reaches All-Time High: ReportEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Title: Worldwide Vaccine Availability Reaches All-Time High: ReportCategory: Health NewsCreated: 10/21/2009 12:10:00 PMLast Editorial Review: 10/22/2009
Source: MedicineNet Crohn's Disease General - October 22, 2009 Category: Gastroenterology Source Type: consumer
Purified Micronized Flavonoid Fraction Ameliorates the Injury of Spleen and Ileum Secondary to Hepatic Ischemia–Reperfusion in RatsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusion The results of this study indicated that MPFF pretreatment significantly limited the injury to the small intestine and spleen
induced by hepatic ischemia–reperfusion in rats.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-009-1018-7Authors
Fahrettin Yildiz, Harran University Medical Faculty Department of General Surgery Sanliurfa TurkeyAlpaslan Terzi, Harran University Medical Faculty Department of General Surgery Sanliurfa TurkeySacit Coban, Gaziantep University Department of General Surgery Gaziantep TurkeyMuharrem Bitiren, Harran University Medical Faculty Depar...
Source: Digestive Diseases and Sciences - October 22, 2009 Category: Gastroenterology Tags: Digestive Diseases and Sciences Source Type: journals
The Effects of a Fat- and Sugar-Enriched Diet and Chronic Stress on Nonalcoholic Fatty Liver Disease in Male Wistar RatsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusion The observations strongly suggest that chronic stress can aggravate fat- and sugar-enriched diet-induced NAFLD from steatosis
to steatohepatitis in male Wistar rats, although VO is not changed.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-009-1019-6Authors
J.-h. Fu, China Pharmaceutical University Department of Physiology 24 Tong Jia Xiang Nanjing People’s Republic of ChinaH.-s. Sun, China Pharmaceutical University Department of Physiology 24 Tong Jia Xiang Nanjing People’s Republic of ChinaY. Wang, China Pharmaceutical University Department of Physiology 24 To...
Source: Digestive Diseases and Sciences - October 22, 2009 Category: Gastroenterology Tags: Digestive Diseases and Sciences Source Type: journals
Implication of Normal Liver Enzymes in Liver DiseaseEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
This article suggests future research should focus on alternative noninvasive markers of liver damage vs. ALT levels, given many individuals have significant liver disease but normal ALT levels. Journal of Viral Hepatitis
Source: Medscape Gastroenterology Headlines - October 22, 2009 Category: Gastroenterology Tags: Gastroenterology Source Type: info
Neurophysiologic evaluation of convergent afferents innervating the human esophagus and area of referred pain on the anterior chest wall.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Noxious stimuli in the esophagus cause pain that is referred to the anterior chest wall due to convergence of visceral and somatic afferents within the spinal cord. We sought to characterize the neurophysiologic responses of these convergent spinal pain pathways in man studying 12-healthy subjects over 3-visits (V1, V2 and V3). Esophageal pain thresholds (Eso-PT) were assessed using electrical stimulation and anterior chest wall pain thresholds (ACW-PT) using a contact heat thermode. Esophageal evoked potentials (EEP) were recorded from the vertex following 200-electrical stimuli and anterior chest wall evoked potentia...
Source: Am J Physiol Gastroi... - October 22, 2009 Category: Gastroenterology Authors: Hobson AR, Chizh B, Hicks K, Aziz Q, Worthen S, Lawerence P, Dewit O, Boyle Y, Dukes G Tags: Am J Physiol Gastrointest Liver Physiol Source Type: journals
Inflammatory cells regulate p53 and caspases in acute pancreatitis.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The inflammatory response during pancreatitis regulates necrotic and apoptotic rates of parenchymal cells. Neutrophil depletion using anti-polymorphonuclear serum (anti-PMN) increases apoptosis in experimental pancreatitis but the mechanism has not been determined. Our study was designed to investigate signaling mechanisms in pancreatic parenchymal cells regulating death responses with neutrophil depletion. Rats were neutrophil depleted with anti-PMN treatment. Then cerulein pancreatitis was induced, followed by measurements of apoptosis signaling pathways. There was greater activation of executioner caspases-3 in the ...
Source: Am J Physiol Gastroi... - October 22, 2009 Category: Gastroenterology Authors: Nakamura Y, Do JH, Yuan J, Odinokova IV, Mareninova OA, Gukovskaya AS, Pandol SJ Tags: Am J Physiol Gastrointest Liver Physiol Source Type: journals
Neurotransmission in Lower Esophageal Sphincter of W/Wv Mutant Mice.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
To address the controversy surrounding the role of interstitial Cells of Cajal (ICC) in nitrergic neurotransmission to gastrointestinal smooth muscle, circular smooth muscle from the lower esophageal sphincter (LES) of W/W(v) wild-type and mutant (ICC-deficient) mice were studied using intracellular and tension recordings in vitro. Resting membrane potential (MP) was more negative and the spontaneous unitary potentials diminished in mutant mice. In wild-type mice, nerve stimulation induced a biphasic inhibitory junction potential (IJP) consisting of a fast initial IJP followed by a long-lasting slow IJP (LSIJP). The IJ...
Source: Am J Physiol Gastroi... - October 22, 2009 Category: Gastroenterology Authors: Zhang Y, Carmichael SA, Wang XY, Huizinga JD, Paterson WG Tags: Am J Physiol Gastrointest Liver Physiol Source Type: journals
ABCB11 gene mutations in Chinese children with progressive intrahepatic cholestasis and low γ glutamyltransferaseEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a severe autosomal recessive liver disorder of childhood that can cause cholestasis and progress to end-stage liver disease. ABCB11 gene mutations causing PFIC2 have been reported in some population groups, but not in mainland Chinese. To elucidate the existence of and characterize ABCB11 gene mutations in mainland Chinese with progressive intrahepatic cholestasis and low [gamma] glutamyltransferase (GGT). Twenty-four children presenting with progressive intrahepatic cholestasis and low GGT were admitted to a tertiary paediatric hospital in eastern China from ...
Source: Liver International - October 21, 2009 Category: Gastroenterology Authors: Li-Yan Liu, Zhong-Lin Wang, Xiao-Hong Wang, Qi-Rong Zhu, Jian-She Wang Source Type: journals
Diabetes mellitus as an independent prognostic predictor and its association with renal dysfunction in patients with hepatocellular carcinomaEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
This study investigated the interaction between DM, cirrhosis and renal dysfunction and the impact of these factors on HCC. A prospective database of 1713 HCC patients was analysed. A total of 392 (22.9%) patients were diabetic. Diabetic patients had a significantly higher Child[ndash]Turcotte[ndash]Pugh (CTP) score, model for end-stage liver disease score and serum creatinine level, but had significantly lower serum albumin, sodium, alanine aminotransferase, aspartate aminotransferase and bilirubin levels. The serum creatinine level progressively increased and correlated well with increasing CTP class in both diabetic and...
Source: Liver International - October 21, 2009 Category: Gastroenterology Authors: Teh-Ia Huo, Chia-Yang Hsu, Yi-Hsiang Huang, Cheng-Yuan Hsia, Han-Chieh Lin, Pui-Ching Lee, Che-Chuan Loong, Jen-Huey Chiang, Yi-You Chiou, Shou-Dong Lee Source Type: journals
Mechanisms of gastric emptying disturbances in chronic and acute inflammation of the distal gastrointestinal tractEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
It is unclear why patients with inflammation of the distal bowel complain of symptoms referable to the upper gastrointestinal tract, specifically to gastric emptying (GE) disturbances. Thus we aimed to determine occurrence and putative pathomechanisms of gastric motor disorders in such patients. Thirteen healthy subjects (CON), 13 patients with Crohn's disease (CD), 10 with ulcerative colitis (UC), and 7 with diverticulitis (DIV) underwent a standardized 13C-octanoic acid gastric emptying breath test. Plasma glucose, CCK, peptide YY, and glucagon-like peptide-1 (GLP-1) were measured periodically and correlated with GE para...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Keller, J., Beglinger, C., Holst, J. J., Andresen, V., Layer, P. Tags: NEUROREGULATION AND MOTILITY Source Type: journals
Differential adipokine response in genetically predisposed lean and obese rats during inflammation: a role in modulating experimental colitis?Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The relationship between a predisposition to obesity and the development of colitis is not well understood. Our aim was to characterize the adipokine response and the extent of colitis in diet-induced obese (DIO) rats. DIO and control, diet-resistant (DR) animals were administered either saline or trinitrobenzene sulfonic acid (TNBS) to induce colitis. Macroscopic damage scores and myeloperoxidase (MPO) activity were measured to determine the extent of inflammation. Trunk blood was collected for the analysis of plasminogen activator inhibitor-1 (PAI-1) as well as leptin, ghrelin, and adiponectin. Colonic epithelial physiol...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Hyland, N. P., Chambers, A. P., Keenan, C. M., Pittman, Q. J., Sharkey, K. A. Tags: INFLAMMATION/IMMUNITY/MEDIATORS Source Type: journals
Mechanisms underlying modulation of monocarboxylate transporter 1 (MCT1) by somatostatin in human intestinal epithelial cellsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Somatostatin (SST), an important neuropeptide of the gastrointestinal tract has been shown to stimulate sodium chloride absorption and inhibit chloride secretion in the intestine. However, the effects of SST on luminal butyrate absorption in the human intestine have not been investigated. Earlier studies from our group and others have shown that monocarboxylate transporter (MCT1) plays an important role in the transport of butyrate in the human intestine. The present studies were undertaken to examine the effects of SST on butyrate uptake utilizing postconfluent human intestinal epithelial Caco2 cells. Apical SST treatment...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Saksena, S., Theegala, S., Bansal, N., Gill, R. K., Tyagi, S., Alrefai, W. A., Ramaswamy, K., Dudeja, P. K. Tags: HORMONES AND SIGNALING Source Type: journals
Effects of progesterone on motility and prostaglandin levels in the distal guinea pig colonEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Progesterone (P4) inhibits the gastrointestinal muscle contraction by downregulating Gq/11 proteins that mediate contraction, by upregulating Gs proteins that mediate relaxation, and by altering the pattern of cyclooxygenase (COX) enzymes and prostaglandins. We aimed to examine whether P4 treatment of guinea pigs in vivo affects basal colon motility [basal motility index (MI)] by altering the levels and actions of PGF2 and PGE2. Guinea pigs were treated with intramuscular (IM) P4 for 4 days. The BASAL MI, the PGF2-induced contraction, and PGE2-induced inhibition of contraction were examined in muscle strips and cells. The ...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Xiao, Z. L., Biancani, P., Behar, J. Tags: NEUROREGULATION AND MOTILITY Source Type: journals
Effect of meal volume and calorie load on postprandial gastric function and emptying: studies under physiological conditions by combined fiber-optic pressure measurement and MRIEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
This study assessed the effects of meal volume (MV) and calorie load (CL) on gastric function. MRI and a minimally invasive fiber-optic recording system (FORS) provided simultaneous measurement of gastric volume and pressure changes during gastric filling and emptying of a liquid nutrient meal in physiological conditions. The gastric response to 12 iso-osmolar MV-CL combinations of a multinutrient drink (MV: 200, 400, 600, 800 ml; CL: 200, 300, 400 kcal) was tested in 16 healthy subjects according to a factorial design. Total gastric volume (TGV) and gastric content volume (GCV = MV + secretion) were measured by MRI during...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Kwiatek, M. A., Menne, D., Steingoetter, A., Goetze, O., Forras-Kaufman, Z., Kaufman, E., Fruehauf, H., Boesiger, P., Fried, M., Schwizer, W., Fox, M. R. Tags: NEUROREGULATION AND MOTILITY Source Type: journals
Contribution of different triggers to the gastric accommodation reflex in humansEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Accommodation of the stomach consists of a vagally mediated relaxation of the proximal stomach, providing the meal with a reservoir. Our aim was to study whether, similar to other vagally mediated processes, the accommodation reflex is also determined by cephalic, oropharyngeal, gastric, and intestinal phases. Eleven healthy subjects underwent in randomized order five gastric barostat studies and two satiety drinking tests. In all studies, isobaric tone measurements (at minimal distending pressure + 2 mmHg) were performed 20 min before and 20 min after a nutrient stimulus. The stimuli included only visual and olfactory exp...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Vanden Berghe, P., Janssen, P., Kindt, S., Vos, R., Tack, J. Tags: NEUROREGULATION AND MOTILITY Source Type: journals
Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivationEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Sustained activation of the c-Jun NH2-terminal kinase (JNK) signaling pathway mediates the development and progression of experimental diet-induced nonalcoholic fatty liver disease (NAFLD). Delineating the mechanism of JNK overactivation in the setting of a fatty liver is therefore essential to understanding the pathophysiology of NAFLD. Both human and experimental NAFLD are associated with oxidative stress and resultant lipid peroxidation, which have been proposed to mediate the progression of this disease from simple steatosis to steatohepatitis. The ability of oxidants and the lipid peroxidation product 4-hydroxynonenal...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Singh, R., Wang, Y., Schattenberg, J. M., Xiang, Y., Czaja, M. J. Tags: LIVER AND BILIARY TRACT Source Type: journals
Parsing apical oxalate exchange in Caco-2BBe1 monolayers: siRNA knockdown of SLC26A6 reveals the role and properties of PAT-1Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The purpose of this investigation was to quantitate the contribution of the anion exchanger PAT-1 (putative anion transporter-1), encoded by SLC26A6, to oxalate transport in a model intestinal epithelium and to discern some characteristics of this exchanger expressed in its native environment. Control (Con) Caco-2 BBe1 monolayers, 6–8 days postseeding, were compared with those transfected with a small interfering RNA targeted to SLC26A6 (A6KD). Radiotracer and Ussing chamber techniques were used to determine the transepithelial unidirectional fluxes of Ox2–, Cl–, and SO42– whereas fluorometric/BCECF...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Freel, R. W., Morozumi, M., Hatch, M. Tags: MUCOSAL BIOLOGY Source Type: journals
Caveolin-1 mediates endotoxin inhibition of endothelin-1-induced endothelial nitric oxide synthase activity in liver sinusoidal endothelial cellsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The objective of this study was to investigate the molecular mechanism of Cav-1 in the regulation of LPS suppression of ET-1-mediated eNOS activation in LSECs by examining the effect of caveolae disruption using methyl-β-cyclodextrin (CD) and filipin. Treatment with 5 mM CD for 30 min increased eNOS activity (+255%, P < 0.05). A dose (0.25 µg/ml) of filipin for 30 min produced a similar effect (+111%, P < 0.05). CD induced the perinuclear localization of Cav-1 and eNOS and stimulated NO production in the same region. Readdition of 0.5 mM cholesterol to saturate CD reversed these effects. Both the combined ...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Kwok, W., Lee, S. H., Culberson, C., Korneszczuk, K., Clemens, M. G. Tags: LIVER AND BILIARY TRACT Source Type: journals
Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitisEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In conclusion, administration of B. bifidum protects against NEC in the neonatal rat model. This protective effect is associated with reduction of inflammatory reaction in the ileum, regulation of main components of mucus layer, and improvement of intestinal integrity.
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Khailova, L., Dvorak, K., Arganbright, K. M., Halpern, M. D., Kinouchi, T., Yajima, M., Dvorak, B. Tags: INFLAMMATION/IMMUNITY/MEDIATORS Source Type: journals
Impact of Roux-en-Y gastric bypass surgery on rat intestinal glucose transportEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Roux-en-Y gastric bypass (RYGB) has become the gold-standard bariatric procedure, partly because of the rapid resolution of accompanying diabetes. There is increasing evidence this is mediated by duodenal exclusion. We hypothesize that duodenal exclusion suppresses intestinal Na+/glucose cotransporter SGLT1-mediated glucose transport, improving glucose handling, and aimed to test this in a rodent RYGB model. Sprague-Dawley rats underwent sham procedure or duodenal exclusion by RYGB (10 cm Roux, 16 cm biliopancreatic limbs). Animals were maintained for 3 wk on a Western diet, before harvest at 10 AM, 4 PM, and 10 PM. Sectio...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Stearns, A. T., Balakrishnan, A., Tavakkolizadeh, A. Tags: MUCOSAL BIOLOGY Source Type: journals
Role of thin-filament regulatory proteins in relaxation of colonic smooth muscle contractionEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Coordinated regulation of smooth muscle contraction and relaxation is required for colonic motility. Contraction is associated with phosphorylation of myosin light chain (MLC20) and interaction of actin with myosin. Thin-filament regulation of actomyosin interaction is modulated by two actin-binding regulatory proteins: tropomyosin (TM) and caldesmon (CaD). TM and CaD are known to play crucial role in actomyosin interaction promoting contraction. Contraction is associated with phosphorylation of the small heat shock protein HSP27, concomitant with the phosphorylation of TM and CaD. Phosphorylation of HSP27 is attributed as...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Somara, S., Gilmont, R., Bitar, K. N. Tags: NEUROREGULATION AND MOTILITY Source Type: journals
Protease activation during in vivo pancreatitis is dependent on calcineurin activationEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In this study, we hypothesized that PP2B mediates in vivo protease activation and pancreatitis severity. To test this, pancreatitis was induced in mice over 8 h by administering hourly intraperitoneal injections of the cholecystokinin analog caerulein (50 µg/kg). Treatment with the PP2B inhibitor FK506 at 1 and 8 h after pancreatitis induction reduced trypsin activities by greater than 50% (P < 0.005). Serum amylase and IL-6 was reduced by 86 and 84% relative to baseline (P < 0.0005) at 8 h, respectively. Histological severity of pancreatitis, graded on the basis of pancreatic edema, acinar cell vacuolization, ...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Shah, A. U., Sarwar, A., Orabi, A. I., Gautam, S., Grant, W. M., Park, A. J., Shah, A. U., Liu, J., Mistry, P. K., Jain, D., Husain, S. Z. Tags: HORMONES AND SIGNALING Source Type: journals
Localization of acyl ghrelin- and des-acyl ghrelin-immunoreactive cells in the rat stomach and their responses to intragastric pHEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Acyl ghrelin has a 28-amino acid sequence with O-n-octanoyl acid modification at the serine 3 position, whereas des-acyl ghrelin has no octanoyl acid modification. Although these peptides exert different physiological functions, no previous studies have shown the different localization of acyl ghrelin and des-acyl ghrelin in the stomach. Here we have developed an antibody specific for des-acyl ghrelin that does not crossreact with acyl ghrelin. Both acyl ghrelin- and des-acyl ghrelin-immunoreactive cells were distributed in the oxyntic and antral mucosa of the rat stomach, with higher density in the antral mucosa than oxyn...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Mizutani, M., Atsuchi, K., Asakawa, A., Matsuda, N., Fujimura, M., Inui, A., Kato, I., Fujimiya, M. Tags: HORMONES AND SIGNALING Source Type: journals
Regulation of HSP60 and the role of MK2 in a new model of severe experimental pancreatitisEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The objective of this study was to investigate the role of MAPKAP kinase 2 (MK2) and heat shock protein (HSP) HSP60 in the pathogenesis of a new model of severe acute pancreatitis (AP). MK2 plays a significant role in the regulation of cytokines. It has been shown that induction and expression of several HSPs can protect against experimental pancreatitis. Interplay between both systems seems of high interest. Mice with a homozygous deletion of the MK2 gene were used. Severe AP was induced by combined intraperitoneal injections of cerulein with lipopolysaccharide (LPS). Severity of AP was assessed by biochemical markers and...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Li, Y.-Y., Ochs, S., Gao, Z.-R., Malo, A., Chen, C.-J., Lv, S., Gallmeier, E., Goke, B., Schafer, C. Tags: INFLAMMATION/IMMUNITY/MEDIATORS Source Type: journals
Protection from diclofenac-induced small intestinal injury by the JNK inhibitor SP600125 in a mouse model of NSAID-associated enteropathyEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In conclusion, these data demonstrate that the JNK pathway is critically involved in the pathogenesis of DCF-induced enteropathy and suggest a potential application of JNK inhibitors in the prevention of NSAID-induced enteropathy.
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Ramirez-Alcantara, V., LoGuidice, A., Boelsterli, U. A. Tags: MUCOSAL BIOLOGY Source Type: journals
The angiogenic effect of probiotic Bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Angiogenesis is required for wound healing and repair, but dysregulated angiogenesis is involved in gastrointestinal inflammation. Bacillus polyfermenticus (B.P.) is a probiotic bacterium clinically used for a variety of intestinal disorders in East Asia. Here we investigated the effect of B.P. on angiogenesis of human intestinal microvascular endothelial cells (HIMECs) and wound healing in intestinal mucosa. Exposure of HIMECs to the conditioned medium of B.P. cultures (B.P. CM) increased cell migration, permeability, and tube formation. Production of the proangiogenic cytokine IL-8 was increased by B.P. CM, and neutraliz...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Im, E., Choi, Y. J., Kim, C. H., Fiocchi, C., Pothoulakis, C., Rhee, S. H. Tags: INFLAMMATION/IMMUNITY/MEDIATORS Source Type: journals
Identification and functional characterization of the intermediate-conductance Ca2+-activated K+ channel (IK-1) in biliary epitheliumEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In the liver, adenosine triphosphate (ATP) is an extracellular signaling molecule that is released into bile and stimulates a biliary epithelial cell secretory response via engagement of apical P2 receptors. The molecular identities of the ion channels involved in ATP-mediated secretory responses have not been fully identified. Intermediate-conductance Ca2+-activated K+ channels (IK) have been identified in biliary epithelium, but functional data are lacking. The aim of these studies therefore was to determine the location, function, and regulation of IK channels in biliary epithelial cells and to determine their potential...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Dutta, A. K., Khimji, A.-k., Sathe, M., Kresge, C., Parameswara, V., Esser, V., Rockey, D. C., Feranchak, A. P. Tags: LIVER AND BILIARY TRACT Source Type: journals
Angiotensin II receptors are expressed and functional in human esophageal mucosaEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In conclusion, Ang II receptors and ACE are expressed in the human esophageal epithelium. The results suggest that AT2-receptor stimulation increases epithelial ion transport, whereas the AT1 receptor inhibits ion transport and increases Rep.
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Casselbrant, A., Edebo, A., Hallersund, P., Spak, E., Helander, H. F., Jonson, C., Fandriks, L. Tags: HORMONES AND SIGNALING Source Type: journals
New method of manometric measurement of gastroduodenal motility in conscious mice: effects of ghrelin and Y2 depletionEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Since no previous studies have reported dual measurements of stomach and duodenal motility in conscious mice, we developed a manometric method to measure the gastroduodenal motility in the physiological fed and fasted states of conscious mice. By this method we measured, for the first time, the gastroduodenal motility in Y2 knockout mice and analyzed the effects of ghrelin on the gastroduodenal motility in conscious mice. To evaluate this new method, we provide the comparison on the effects of CCK-8 examined by present and previous methods. In the fasted state of mice, phase III-like contractions with frequencies of 7.8 &p...
Source: AJP: Gastrointestinal and Liver Physiology - October 21, 2009 Category: Gastroenterology Authors: Tanaka, R., Inui, A., Asakawa, A., Atsuchi, K., Ataka, K., Fujimiya, M. Tags: INNOVATIVE METHODOLOGY Source Type: journals
Microsatellite instability screening should be done for right-sided colon cancer patients less than 60 years of ageEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusions Colorectal cancers with MSI-H were predominantly located on the right side and had an early pathological stage. The results
of this study suggest that microsatellite instability test should be used for all patients under 60 years of age with right-sided
colon cancer.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0815-yAuthors
Chia-Lin Chou, National Yang-Ming University Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital No 201, Section 2, Shih-Pai Road Taipei 11217 TaiwanJen-Kou Lin, National Yang-Ming University ...
Source: International Journal of Colorectal Disease - October 21, 2009 Category: Gastroenterology Tags: International Journal of Colorectal Disease Source Type: journals
Coffee Could Stall Liver Disease Progression (CME/CE)Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Drinking three or more cups of coffee daily lowers the risk of liver disease progression for patients with chronic hepatitis C, researchers say.
Source: MedPage Today Gastroenterology - October 21, 2009 Category: Gastroenterology Source Type: news
Gastroesophageal reflux symptoms are long-lasting and impair QoLEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Gastroesophageal reflux symptoms are prevalent in the community and are long lasting, say researchers.
Source: MedWire News - Gastroenterology - October 21, 2009 Category: Gastroenterology Source Type: news
PseudomelanosisEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
During a routine endoscopy for Barrett's related dysplasia surveillance, this mucosal abnormality was identified.
On endoscopy, these pigmented areas of mucosa in the antrum, pylorus, and duodenum were seen. This is the classic endoscopic finding of pseudomelanosis of the gastrointestinal tract, whose features include a brownish-black pigmentation of the mucosa in a non-inflamed, random, speckled pattern. There is no apparent associated mucosal thickening or other defects.
Pseudomelanosis has been observed to occur anywhere along the length of the gastrointestinal tract. The pigment of pseudomelanosis has not been c...
Source: The Digital Atlas of Video Education - Gastroenterology - October 21, 2009 Category: Gastroenterology Authors: Mohammad Bilal,, Harvard Medical School, David G. Forcione, M.D., Instructor in Medicine, Harvard Medical School, Massachusetts General Hospital, Peter B. Kelsey, M.D., Assistant Professor of Medicine, Harvard Medical School, Massachusetts General Hospita Source Type: info
Rectal endosonography: just how good are we at its interpretation?Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusions If we continue to rely on ERUS as an important step in staging rectal cancer further education may be needed to improve overall
interpretation.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0816-xAuthors
Isabella Mor, Cleveland Clinic Department of Colorectal Surgery A30 9500 Euclid Ave Cleveland OH 44195 USATracy Hull, Cleveland Clinic Department of Colorectal Surgery A30 9500 Euclid Ave Cleveland OH 44195 USAJeffrey Hammel, Cleveland Clinic Department of Colorectal Surgery A30 9500 Euclid Ave Cleveland OH 44195 USAMassarat Zutshi, Cleveland Clinic Department ...
Source: International Journal of Colorectal Disease - October 21, 2009 Category: Gastroenterology Tags: International Journal of Colorectal Disease Source Type: journals
Fulminant amebic colitis with lower GI bleed with liver abscessEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00384-009-0824-xAuthors
M. Atif Khan, Postgraduate Institute of Medical Education and Research Department of General Surgery Kabir Colony, Anoopshahr Road Aligarh 202002 Uttar Pradesh IndiaG. R. Verma, Postgraduate Institute of Medical Education and Research Department of General Surgery Chandigarh 160012 IndiaH. M. Lokesh, Postgraduate Institute of Medical Education and Research Department of General Surgery Chandigarh 160012 India
Journal International Journal of Colorectal DiseaseOnline ISSN 1432-1262Print ISSN 0179-1958
Source: International Journal of Colorectal Disease - October 21, 2009 Category: Gastroenterology Tags: International Journal of Colorectal Disease Source Type: journals
The Bowels Of InfectionEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Current research suggests that latent cytomegalovirus (CMV) infection may exacerbate inflammatory bowel disease (IBD). The related report by Onyeagocha et al, "Latent cytomegalovirus infection exacerbates experimental colitis," appears in the November 2009 issue of The American Journal of Pathology. CMV infects between 50% and 80% of adults in the United States.
Source: Irritable-Bowel Syndrome News From Medical News Today - October 21, 2009 Category: Gastroenterology Tags: Irritable-Bowel Syndrome Source Type: news
Drinking Coffee Slows Progression Of Liver Disease In Chronic Hepatitis C SufferersEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Patients with chronic hepatitis C and advanced liver disease who drink three or more cups of coffee per day have a 53% lower risk of liver disease progression than non-coffee drinkers according to a new study led by Neal Freedman, Ph.D., MPH, from the National Cancer Institute (NCI). The study found that patients with hepatitis C-related bridging fibrosis or cirrhosis who did not respond to standard disease treatment benefited from increased coffee intake.
Source: Liver Disease / Hepatitis News From Medical News Today - October 21, 2009 Category: Gastroenterology Tags: Liver Disease / Hepatitis Source Type: news
Effect of hemorrhoidectomy on anorectal physiologyEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusion Overactivity of the anal sphincter in patients with hemorrhoids is secondary and according to our results. Hypertension of
the sphincter muscle in patients with hemorrhoids is significantly increased in patients with advanced degrees of hemorrhoids.
Therefore, it is not recommended to postpone surgery and indicate patients with advanced degrees of hemorrhoids to hemorrhoidectomy.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0810-3Authors
Kamil Vysloužil, Palacký University Olomouc 2nd Surgical Department, University Hospital Olomouc I.P.Pavlova 6 775 20 Olom...
Source: International Journal of Colorectal Disease - October 21, 2009 Category: Gastroenterology Tags: International Journal of Colorectal Disease Source Type: journals
Swine Flu and the ElderlyEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Title: Swine Flu and the ElderlyCategory: Health FactsCreated: 10/21/2009 12:31:00 PMLast Editorial Review: 10/21/2009 12:31:16 PM
Source: MedicineNet Crohn's Disease General - October 21, 2009 Category: Gastroenterology Source Type: consumer
Swine Flu 101: College Survival TipsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Title: Swine Flu 101: College Survival TipsCategory: Health FactsCreated: 10/21/2009 11:53:00 AMLast Editorial Review: 10/21/2009 11:53:32 AM
Source: MedicineNet Crohn's Disease General - October 21, 2009 Category: Gastroenterology Source Type: consumer
Swine Flu FAQEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Title: Swine Flu FAQCategory: Health NewsCreated: 4/22/2009Last Editorial Review: 10/21/2009
Source: MedicineNet Crohn's Disease General - October 21, 2009 Category: Gastroenterology Source Type: consumer
Votrient Approved for Advanced Kidney CancerEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Title: Votrient Approved for Advanced Kidney CancerCategory: Health NewsCreated: 10/20/2009 12:10:00 PMLast Editorial Review: 10/21/2009
Source: MedicineNet Crohn's Disease General - October 21, 2009 Category: Gastroenterology Source Type: consumer
Cancer Drug May Help SclerodermaEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Title: Cancer Drug May Help SclerodermaCategory: Health NewsCreated: 10/20/2009 4:10:00 PMLast Editorial Review: 10/21/2009
Source: MedicineNet Crohn's Disease General - October 21, 2009 Category: Gastroenterology Source Type: consumer
Health Tip: You Need Vitamin B-12Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Title: Health Tip: You Need Vitamin B-12Category: Health NewsCreated: 10/21/2009 8:10:00 AMLast Editorial Review: 10/21/2009
Source: MedicineNet Crohn's Disease General - October 21, 2009 Category: Gastroenterology Source Type: consumer
The effects of hepatitis C recurrence on health-related quality of life in liver transplant recipientsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Orthotopic liver transplantation (OLT) remains the definitive treatment for hepatitis C (HCV). Although HCV is the number one indication for OLT in the USA, health-related quality of life (HRQOL) scores are consistently lower for HCV patients when compared with all OLT indications. HCV is unique in that 95% of transplanted patients experience virological recurrence of HCV hepatitis. Despite few physical manifestations of disease at the time of HCV recurrence, patients report an impaired quality of life and functional status compared with OLT recipients without recurrence. Studies show that patient knowledge of the diagnosi...
Source: Liver International - October 20, 2009 Category: Gastroenterology Authors: Hillary Bownik, Sammy Saab Source Type: journals
Controversies about occult hepatitis B virus infection.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
We read with great interest the paper written by Shi et al, reviewing the molecular characteristics and stages of chronic hepatitis B virus (HBV) infection. We think that some points in the definition of occult HBV infection (OBI) and their conclusion about the management of OBI may need further considerations.
PMID: 19842236 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - October 20, 2009 Category: Gastroenterology Authors: Ozaslan E, Purnak T Tags: World J Gastroenterol Source Type: journals
Travel of a mis-swallowed long spoon to the jejunum.Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
We report a rare case of a coffee spoon that was swallowed accidentally and passed through the pylorus and duodenal loop and reached the jejunum, with no complications.
PMID: 19842235 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - October 20, 2009 Category: Gastroenterology Authors: Song Y, Guo H, Wu JY Tags: World J Gastroenterol Source Type: journals
