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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 2.

TLR4 monoclonal antibody blockade suppresses dextran-sulfate-sodium-induced colitis in miceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: Blocking TLR4 by TLR4mAb can prevent the development of DSS-induced colitis through the TLR4-P38MAPK-c-jun pathway.
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Yi Liu, Zhijun Zhang, Lei Wang, Juan Li, Le Dong, Wenjie Yue, Jian Chen, Xu Sun, Liang Zhong, Dayu Sun Source Type: journals

Prevalence, human leukocyte antigen typing and strategy for screening among Asian first-degree relatives of children with celiac diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: In this first Asian study on a limited number of families of children with CD, 4.4% of the first-degree relatives had CD. Only 15% of the first-degree relatives were negative for HLA DQ2/DQ8. Initial evaluation with HLA and serology followed by only serial serology in HLA-positive relatives is recommended.
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Anshu Srivastava, Surender Kumar Yachha, Amrita Mathias, Farah Parveen, Ujjal Poddar, Suraksha Agrawal Source Type: journals

Clinical manifestations and survival of patients with hepatocellular carcinoma and cardiac metastasisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: Hepatocellular carcinoma patients with cardiac metastases were in the advanced stages. These patients had limited survival from the diagnosis of cardiac metastases. The most common cause of death was related to HCC per se or the underlying liver disease. Only a few patients expired because of cardiac metastases.
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Yu-Chun Liu, Yi-Lwun Ho, Guan-Tarn Huang, Ding-Shinn Chen, Jin-Chuan Sheu, Chien-Hung Chen Source Type: journals

Factors associated with nutritional status in liver transplant patients who survived the first year after transplantationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: No influence on nutritional status was observed for peri- or postoperative factors after 3 or 12 months of follow up. As expected, dietary factors, especially adequate calorie intake, were always associated with nutritional status during all periods analyzed.
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Luciana de Carvalho, Edison Roberto Parise, Didier Samuel Source Type: journals

Laparoscopic splenectomy may be a superior supportive intervention for cirrhotic patients with hypersplenismemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: Laparoscopic splenectomy may be superior to partial splenic embolization as a supportive intervention for cirrhotic patients with hypersplenism. Future prospective, randomized controlled patient studies are required to confirm these findings.
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Morimasa Tomikawa, Tomohiko Akahoshi, Keishi Sugimachi, Yasuharu Ikeda, Kisaku Yoshida, Yuichi Tanabe, Hirofumi Kawanaka, Kenji Takenaka, Makoto Hashizume, Yoshihiko Maehara Source Type: journals

Asian perspectives in the management of inflammatory bowel disease: Findings from a recent surveyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: Clinical practice with regards to IBD diagnosis and management varies within Asia.5-ASA is the preferred treatment and maintenance therapy for mild-to-moderate IBD.
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Joseph JY Sung, Michael A Kamm, Philippe Marteau Source Type: journals

Gastric metastasis of hepatocellular carcinoma via a possible existing retrograde hematogenous pathwayemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: When cirrhotic patients with portal hypertension have HCC with PVT, a hematogenous pathway can exist for gastric metastasis of tumor thrombi involving hepatofugal flow to the stomach after TAE or EVL apart from the major pathway of direct invasion.
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Ming-Luen Hu, Wei-Chen Tai, Seng-Kee Chuah, Yi-Chun Chiu, Keng-Liang Wu, Yeh-Pin Chou, Chung-Mou Kuo, Tsung-Hui Hu, King-Wah Chiu Source Type: journals

Naturally occurring K vitamins inhibit pancreatic cancer cell survival through a caspase-dependent pathwayemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: These data show that naturally-occurring, non-toxic K vitamins can inhibit the survival of some pancreatic cancer cell lines. These novel, safe and clinically-utilized agents initiate a caspase-dependent apoptosis via the MAP kinase pathway and could potentially benefit patients with pancreatic cancer either as a single agent or in combination with chemotherapy for treatment, or for prevention of recurrence of pancreas cancer post resection.
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Shayna L Showalter, Ziqiu Wang, Christina L Costantino, Agnieszka K Witkiewicz, Charles J Yeo, Jonathan R Brody, Brian I Carr Source Type: journals

Radiofrequency ablation therapy for hepatocellular carcinoma in elderly patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: Elderly HCC patients, who have good performance status, should be treated in the same manner and with the same strategy as young HCC patients.
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Atsushi Hiraoka, Kojiro Michitaka, Norio Horiike, Satoshi Hidaka, Takahide Uehara, Soichi Ichikawa, Aki Hasebe, Yasunao Miyamoto, Tomoyuki Ninomiya, Ichiro Sogabe, Yoshihiro Ishimaru, Hideki Kawasaki, Yohei Koizumi, Masashi Hirooka, Yoshimasa Yamashita, M Source Type: journals

Evidence for the insufficient evaluation and undertreatment of chronic hepatitis B infection in a predominantly low-income and immigrant populationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: After the diagnosis of HBV infection, few patients in our population received laboratory evaluation to determine eligibility for HBV treatment. Furthermore, only a small percentage received HBV treatment. Further research needs to be done to validate these findings in other populations and understand barriers to receiving HBV treatment.
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Chin W Jung, Jennifer Tan, Nelly Tan, Melissa N Kuo, Ashwin Ashok, Samantha J Eells, Loren G Miller Source Type: journals

What are 'true normal' liver stiffness values using FibroScan®?: a prospective study in healthy living liver and kidney donors in South Koreaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
To identify the normal range of liver stiffness (LS) values by recruiting healthy living liver and kidney donors in South Korea. Liver stiffness measurement (LSM) was performed in 69 healthy living liver and kidney donors who were admitted for transplantation. None of the subjects suffered from diabetes mellitus, hypertension, hepatitis B virus infection, hepatitis C virus infection, heart dysfunction, liver dysfunction or metabolic syndrome. LSM failure rate was 2.7%. Among 12 liver donors (17.4%) with available liver histology, eight showed normal liver histology and four showed liver steatosis of
Source: Liver International - November 19, 2009 Category: Gastroenterology Authors: Seung Up Kim, Gi Hong Choi, Woong Kyu Han, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Jin Sub Choi, Seung Choul Yang, Eun Hee Choi, Sang Hoon Ahn, Kwang-Hyub Han, Chae Yoon Chon Source Type: journals

Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cellsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study aimed to investigate the paracrine effects of hepatocarcinoma cells on human HSC using a co-culture system. Huh7 or HepG2 cells, human hepatocarcinoma cell lines, were co-cultured with primary human HSC. Intracellular calcium mobilization, proliferation, migration, expression of pro-angiogenic and fibrogenic genes, smooth muscle [alpha]-actin ([alpha]-SMA) protein expression, inflammatory properties (nuclear factor kappa B activation and interleukin 8 secretion) and intracellular signalling pathways (AKT and ERK) were analysed in HSC. Culture of HSC with Huh7 cells for 24 h stimulated HSC proliferation, migratio...
Source: Liver International - November 19, 2009 Category: Gastroenterology Authors: Pau Sancho-Bru, Elena Juez, Montserrat Moreno, Valeria Khurdayan, Manuel Morales-Ruiz, Jordi Colmenero, Vicente Arroyo, David A. Brenner, Pere Ginès, Ramón Bataller Source Type: journals

Endotipsitis-persistent infection of transjugular intrahepatic portosystemic shunt: pathogenesis, clinical features and managementemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Transjugular intrahepatic portosystemic shunt (TIPS) is in widespread use for the decompression of portal pressure. The entity of persistent TIPS infection, also known as 'endotipsitis' is a rare but serious complication of TIPS insertion. The exact definition of 'endotipsitis' is still debated, but involves persistent bacteremia and fever together with either shunt occlusion, or vegetation, or bacteremia in the presence of a patent shunt, when other sources of bacteremia have been ruled out. To date, approximately 40 cases of 'endotipsitis' have been described, with predominance for male and alcoholic hepatitis patients. ...
Source: Liver International - November 19, 2009 Category: Gastroenterology Authors: Meir Mizrahi, Tomer Adar, Daniel Shouval, Allan I. Bloom, Oren Shibolet Source Type: journals

Artificial and bioartificial liver devices: present and futureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Liver failure is associated with high morbidity and mortality without transplantation. There are two types of device for temporary support: artificial and bioartificial livers. Artificial livers essentially use non-living components to remove the toxins accumulated during liver failure. Bioartificial livers have bioreactors containing hepatocytes to provide both biotransformation and synthetic liver functions. We review here the operating principles, chemical effects, clinical effects and complications of both types, with specific attention paid to bioartificial systems. Several artificial support systems have FDA marketin...
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Carpentier, B, Gautier, A, Legallais, C Tags: GUT Recent advances in clinical practice Source Type: journals

Long-term safety of Infliximab for the treatment of inflammatory bowel disease: does blocking TNF{alpha} reduce colitis-associated colorectal carcinogenesis?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Biancone, L, Petruzziello, C, Calabrese, E, Zorzi, F, Naccarato, P, Onali, S, Pallone, F Tags: PostScript Source Type: journals

Discordant practice and limited histopathological assessment in gastrointestinal neuromuscular diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Martin, J E, Hester, T W, Aslam, H, Sinha, S, Knowles, C H Tags: PostScript Source Type: journals

Interleukin 2 targeted therapy in inflammatory bowel diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Yarkoni, S, Sagiv, Y, Kaminitz, A, Askenasy, N Tags: PostScript Source Type: journals

Haemoglobin and non-alcoholic fatty liver disease: further evidence from a population-based studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Xu, L, Xu, C-f, Yu, C-h, Miao, M, Li, Y-m Tags: PostScript Source Type: journals

Insulin resistance and geographical origin: major predictors of liver fibrosis and response to peginterferon and ribavirin in HCV-4email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: Insulin resistance and geographical origin are major predictors of liver fibrosis and response to peginterferon and ribavirin in HCV-4 patients. Insulin resistance is frequently encountered in these patients, and correlated independently with serum HCV-RNA.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Moucari, R, Ripault, M-P, Martinot-Peignoux, M, Voitot, H, Cardoso, A-C, Stern, C, Boyer, N, Maylin, S, Nicolas-Chanoine, M-H, Vidaud, M, Valla, D, Bedossa, P, Marcellin, P Tags: Cirrhosis Hepatology Source Type: journals

An unusual case of gastric erosionsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Jothimani, D K, Zanetto, U, Owen, R J, Lawson, A J, Wilson, P G Tags: GUT Snapshot Editor's quiz Source Type: journals

A novel technique for selective NF-{kappa}B inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: NF-B inhibiting decoy oligodeoxynucleotide-loaded gelatin nanoparticles is a novel tool to selectively inhibit NF-B activation in Kupffer cells in vivo. Thus, liver injury can be reduced in experimental fulminant hepatitis, but increased at ischaemia–reperfusion.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Hoffmann, F, Sass, G, Zillies, J, Zahler, S, Tiegs, G, Hartkorn, A, Fuchs, S, Wagner, J, Winter, G, Coester, C, Gerbes, A L, Vollmar, A M Tags: Hepatology Source Type: journals

JournalScanemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Aithal, G. Tags: JournalScan Source Type: journals

Recent advances in autoimmune pancreatitisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Autoimmune pancreatitis (AIP) is distinct from calcifying and obstructive forms of chronic pancreatitis. Clinically and histologically it has two distinct subsets: (i) lymphoplasmacytic sclerosing pancreatitis or type 1 AIP which appears to be a systemic disease characterised by abundant infiltration of affected organs with immunoglobulin G4 (IgG4)-positive plasma cells and (2) duct-centric or type 2 AIP characterised by granulocyte epithelial lesions in the pancreas without systemic involvement. In AIP a marked lymphoplasmacytic infiltrate that responds dramatically to steroid therapy suggests an autoimmune aetiology. How...
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Park, D H, Kim, M-H, Chari, S T Tags: GUT Recent advances in basic science, Pancreas and biliary tract, Pancreatitis Source Type: journals

New aspects of an anti-tumour drug: sorafenib efficiently inhibits HCV replicationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: Our data demonstrate that the well-characterised anti-tumour drug sorafenib efficiently blocks HCV replication in vitro. This novel effect of sorafenib should be further explored as an antiviral strategy for patients with chronic HCV infection.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Himmelsbach, K, Sauter, D, Baumert, T F, Ludwig, L, Blum, H E, Hildt, E Tags: Hepatology Source Type: journals

A patient with new onset of thoracic pain, dyspnoea and weight lossemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Lohr, G, Luft, C, Lenz, K Tags: GUT Snapshot Editor's quiz Source Type: journals

Insulin resistance is associated with liver stiffness in HIV/HCV co-infected patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: IR is associated with LS in patients co-infected with HIV/HCV.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Merchante, N, Rivero, A, de los Santos-Gil, I, Merino, D, Marquez, M, Lopez-Ruz, M A, Rodriguez-Bano, J, del Valle, J, Camacho, A, Sanz-Sanz, J, Macias, J, Perez-Camacho, I, Gomez-Mateos, J, Moro, A, Pineda, J A Tags: Hepatology Source Type: journals

Differential regulation of interleukin 17 and interferon {gamma} production in inflammatory bowel diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: Our findings support a role for IL12, TGFβ and IL21 in modulating IL17/IFN production in IBD. The abundant IL17 in inflamed IBD mucosa may help explain the relative lack of efficacy of anti-IFN antibodies in clinical trials of Crohn’s disease.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Rovedatti, L, Kudo, T, Biancheri, P, Sarra, M, Knowles, C H, Rampton, D S, Corazza, G R, Monteleone, G, Di Sabatino, A, MacDonald, T T Tags: Ulcerative colitis Inflammatory bowel disease Source Type: journals

Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditionsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: Colonic cell proliferation was promoted via the JNK pathway in the presence of a HFD but not in the presence of a ND. This novel mechanism may explain the involvement of the JNK pathway in the effect of dietary fat intake on colon carcinogenesis.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Endo, H, Hosono, K, Fujisawa, T, Takahashi, H, Sugiyama, M, Yoneda, K, Nozaki, Y, Fujita, K, Yoneda, M, Inamori, M, Wada, K, Nakagama, H, Nakajima, A Tags: Colon cancer Colorectal cancer Source Type: journals

Digestemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Tags: Digest Source Type: journals

The year in Gut 2009email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Spiller, R. Tags: Pancreas and biliary tract, Pancreatic cancer Editorials Source Type: journals

Biomarkers in IBS: when will they replace symptoms for diagnosis and management?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Barbara, G., Stanghellini, V. Tags: Constipation, Diarrhoea, Irritable bowel syndrome, Coeliac disease Leader Source Type: journals

"Too much, too soon"email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Husein, B, Iqbal, J, Mohammed, A, Shorrock, C Tags: GUT Snapshot Editor's quiz Source Type: journals

Adiponectin and JNK: metabolic/inflammatory pathways affecting gastrointestinal carcinogenesisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Tilg, H., Kaser, A. Tags: Commentaries Source Type: journals

Ulcerative colitis: is it in the diet?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Carbonnel, F., Boutron, M. C. Tags: Commentaries Source Type: journals

HIV/hepatitis C co-infection and hepatic fibrosis: looking beyond HIV-associated immune suppression; the contribution of hepatic steatosis and insulin resistanceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Bhagani, S. Tags: Commentaries Source Type: journals

Selective inhibition of NF-{kappa}B in Kupffer cells: good, but not for everythingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Marra, F. Tags: Commentaries Source Type: journals

Association of adiponectin multimers with Barrett's oesophagusemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: High levels of LMW adiponectin are associated with a decreased risk of Barrett’s oesophagus among patients with GORD. Further human studies are required to confirm these findings, and in vitro studies are needed to understand if there is a mechanism whereby adiponectin may affect Barrett’s metaplasia.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Rubenstein, J H, Kao, J Y, Madanick, R D, Zhang, M, Wang, M, Spacek, M B, Donovan, J L, Bright, S D, Shaheen, N J Tags: Gastro-oesophageal reflux Oesophagus Source Type: journals

Role of dietary fibres, intestinal hypermotility and leukotrienes in the pathogenesis of NSAID-induced small intestinal ulcers in catsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: Insoluble DF, intestinal hypermotility, leukotrienes and cholinergic pathways are implicated in the pathogenesis of small intestinal ulcers induced by NSAIDs.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Satoh, H, Shiotani, S, Otsuka, N, Hatao, K, Nishimura, S Tags: Small intestine Source Type: journals

Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic miceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: CD4+ T cell immunity to gluten leads to a breach of oral gluten tolerance and small intestinal pathology in lymphopenic mice, similar to human coeliac disease. This model will be useful for the study of coeliac disease pathogenesis, and also for testing novel non-dietary therapies for coeliac disease.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Freitag, T L, Rietdijk, S, Junker, Y, Popov, Y, Bhan, A K, Kelly, C P, Terhorst, C, Schuppan, D Tags: Coeliac disease, Stomach and duodenum Small intestine Source Type: journals

An unusual cause of obscure gastrointestinal bleedingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Tai, C-M, Wang, H-P, Hwang, J-C, Lee, T-C, Lee, C-T, Lin, J-T Tags: GUT Snapshot Editor's quiz Source Type: journals

Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case-control study within a European prospective cohort studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: The data support a role for dietary linoleic acid in the aetiology of ulcerative colitis. An estimated 30% of cases could be attributed to having dietary intakes higher than the lowest quartile of linoleic acid intake.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: The IBD in EPIC Study Investigators Tags: Ulcerative colitis Inflammatory bowel disease Source Type: journals

Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: Gene array studies of ulcerative colitis mucosal biopsies identified predictive panels of genes for (non-)response to infliximab. Further study of the pathways involved should allow a better understanding of the mechanisms of resistance to infliximab therapy in ulcerative colitis. ClinicalTrials.gov number, NCT00639821.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Arijs, I, Li, K, Toedter, G, Quintens, R, Van Lommel, L, Van Steen, K, Leemans, P, De Hertogh, G, Lemaire, K, Ferrante, M, Schnitzler, F, Thorrez, L, Ma, K, Song, X-Y R, Marano, C, Van Assche, G, Vermeire, S, Geboes, K, Schuit, F, Baribaud, F, Rutgeerts, Tags: Ulcerative colitis, Editor's choice Inflammatory bowel disease Source Type: journals

Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn's diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: Anti-GP2 autoantibodies constitute novel Crohn’s disease-specific markers, the quantification of which could significantly improve the serological diagnosis of IBD. The expression of GP2 in human enterocytes suggests an important role for anti-GP2 response in the pathogenesis of Crohn’s disease.
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Roggenbuck, D, Hausdorf, G, Martinez-Gamboa, L, Reinhold, D, Buttner, T, Jungblut, P R, Porstmann, T, Laass, M W, Henker, J, Buning, C, Feist, E, Conrad, K Tags: Ulcerative colitis, Pancreas and biliary tract Inflammatory bowel disease Source Type: journals

Genetic Predictors of Treatment-Induced Viral Clearance in Hepatitis Cemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Drs. Dermot McGovern and Gil Melmed comment on a study published in Nature on the ability of an IL-28B polymorphism to predict sustained viral response to hepatitis C treatment. Medscape Genomic Medicine
Source: Medscape Gastroenterology Headlines - November 18, 2009 Category: Gastroenterology Tags: Pathology & Lab Medicine Source Type: info

Announcementemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Source Type: journals

Volume Contentsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Source Type: journals

Author Indexemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Source Type: journals

Subject Indexemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Source Type: journals

Editorial Boardemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Source Type: journals

Season’s Greetings and Best Wishes for 2010email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Journal of Hepatology - November 18, 2009 Category: Gastroenterology Source Type: journals