Gastroenterology
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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 29.
Azathioprine and 6-mercaptopurine treatment for IBD patients
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One of a series designed to provide information for gastroenterologists, primary care clinicians and patients with IBD regarding the use of disease modifying drugs, their indications, side effects and guidelines for safe monitoring.
Source: Gastroenterology and Liver Diseases Specialist Library - Inflammatory bowel disease - September 28, 2009 Category: Gastroenterology Source Type: organizations
ESPEN guidelines on parenteral nutritionEmail this article to a colleague.
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Published September 2009Aims: The ESPEN Guidelines on Adult Parenteral Nutrition (PN) reflect current scientific knowledge in the field of clinical nutrition in adults. They summarise the indications for PN and its anticipated outcomes in respect of the underlying disease, nutritional status and quality of life. They are companion documents to the ESPEN Guidelines on Adult Enteral Nutrition and follow the same general format.
Source: Gastroenterology and Liver Diseases Specialist Library - Small intestine - September 28, 2009 Category: Gastroenterology Source Type: organizations
Methotrexate treatment for patients with IBDEmail this article to a colleague.
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One of a series designed to provide information for gastroenterologists, primary care clinicians and patients with IBD regarding the use of disease modifying drugs, their indications, side effects and guidelines for safe monitoring.
Source: Gastroenterology and Liver Diseases Specialist Library - Inflammatory bowel disease - September 28, 2009 Category: Gastroenterology Source Type: organizations
ESPEN guidelines on parenteral nutritionEmail this article to a colleague.
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Published September 2009Aims: The ESPEN Guidelines on Adult Parenteral Nutrition (PN) reflect current scientific knowledge in the field of clinical nutrition in adults. They summarise the indications for PN and its anticipated outcomes in respect of the underlying disease, nutritional status and quality of life. They are companion documents to the ESPEN Guidelines on Adult Enteral Nutrition and follow the same general format.
Source: Gastroenterology and Liver Diseases Specialist Library - Liver - September 28, 2009 Category: Gastroenterology Source Type: organizations
Effects of preoperative chemoradiotherapy on anal sphincter functions and quality of life in rectal cancer patientsEmail this article to a colleague.
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Conclusions Both total mesorectal excision and preoperative chemoradiotherapy may adversely affect the anorectal function. Careful selection
of the patients who will benefit from neoadjuvant therapy and identifying the patients with a high risk of developing functional
problems may help to improve functional outcomes for the treatment of rectal cancer.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0807-yAuthors
Aras Emre Canda, Dokuz Eylul University School of Medicine Department of Surgery 35340 Inciralti Izmir TurkeyCem Terzi, Dokuz Eylul University School of Medicine D...
Source: International Journal of Colorectal Disease - September 28, 2009 Category: Gastroenterology Tags: International Journal of Colorectal Disease Source Type: journals
ESPEN guidelines on parenteral nutritionEmail this article to a colleague.
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Published September 2009Aims: The ESPEN Guidelines on Adult Parenteral Nutrition (PN) reflect current scientific knowledge in the field of clinical nutrition in adults. They summarise the indications for PN and its anticipated outcomes in respect of the underlying disease, nutritional status and quality of life. They are companion documents to the ESPEN Guidelines on Adult Enteral Nutrition and follow the same general format.
Source: Gastroenterology and Liver Diseases Specialist Library - Inflammatory bowel disease - September 28, 2009 Category: Gastroenterology Source Type: organizations
ESPEN guidelines on enteral nutritionEmail this article to a colleague.
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Published April 2006Aims: The aim of the ESPEN guidelines on enteral nutrition (EN) is to evaluate the evidence on EN in different indications and serve as orientation tools for distinct decisions in clinical practice. Therefore, the single chapters focus on specific questions relevant to the respective indication.
Source: Gastroenterology and Liver Diseases Specialist Library - Small intestine - September 28, 2009 Category: Gastroenterology Source Type: organizations
Questions To Ask Your Doctor - GeneralEmail this article to a colleague.
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Title: Questions To Ask Your Doctor - GeneralCategory: Doctor's ViewsCreated: 6/21/2000 6:38:00 AMLast Editorial Review: 9/28/2009
Source: MedicineNet Crohn's Disease General - September 28, 2009 Category: Gastroenterology Source Type: consumer
This Month in GastroenterologyEmail this article to a colleague.
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Helicobacter pylori infection is a well-established risk factor for gastric carcinogenesis. In animal models, H pylori infection induces a sequence of atrophic gastritis, intestinal metaplasia, dysplasia, and cancer. In some animal models, early eradication of H pylori decreases the incidence of gastric cancer. Whether eradication of H pylori prevents future development of gastric cancer in man remains to be proven.
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Jan Tack, John M. Carethers Tags: This Month in Gastroenterology Source Type: journals
Training in Hepatology: Where Are We Now?Email this article to a colleague.
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Over the past 3 years, I have had the pleasure of serving as an Associate Editor for Gastroenterology, especially in the context of clinical hepatology. This has been an enriching and educational experience and I hope the readership of the Journal and their patients have benefited from the exciting work that has been published. As a separate consideration, I have been interested in training and certification in gastroenterology as Chair of the American Board of Internal Medicine (ABIM) Gastroenterology Board from 1999 to 2003, and as the current Chair of the ABIM Transplant Hepatology Board since 2004. I have elected to wr...
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Bruce R. Bacon Tags: Comment From the Editor Source Type: journals
Synchronous Colorectal Cancer: Not Just Bad Luck?Email this article to a colleague.
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See “A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers,” by Nosho K, Kure S, Irahara N, et al, on page 1609.
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Barbara A. Leggett, Daniel L. Worthley Tags: Editorials Source Type: journals
Serotonin Has a Critical Role in the Pathogenesis of Experimental ColitisEmail this article to a colleague.
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See “Serotonin has a key role in the pathogenesis of experimental colitis,” by Ghia J–E, Li N, Wang H, et al, on page 1649.
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Kara Gross Margolis, Charalabos Pothoulakis Tags: Editorials Source Type: journals
Interleukin-23: Linking Mesenteric Lymph Node Dendritic Cells With Th1 Immunity in Crohn's DiseaseEmail this article to a colleague.
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See “Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease,” by Sakuraba A, Sato T, Kamada N, et al, on page 1736.
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Maria Rescigno, Iliyan D. Iliev Tags: Editorials Source Type: journals
Pathogen-Specific Antibody: Cause or Effect?Email this article to a colleague.
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See “An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice,” by Kobayashi K, Qiao S–W, Yoshida M, et al, on page 1746.
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Tadakazu Hisamatsu, Toshifumi Hibi Tags: Editorials Source Type: journals
Genome-Wide Association Study in Esophageal Squamous Cell CarcinomaEmail this article to a colleague.
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See “Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk,” by Cui R, Kamatani Y, Takahashi A, et al, on page 1768.
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Adam J. Bass, Matthew Meyerson Tags: Editorials Source Type: journals
Food-Induced Severe Chest Pain and HematemesisEmail this article to a colleague.
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Question: An 88-year-old woman ate dry, crispy Yorkshire pudding causing slight epigastric pain. Thirty minutes later she developed sudden-onset, severe, central chest pain radiating to the back and epigastrium, associated with shortness of breathe and bouts of hematemesis. She had a background of mild gastritis and reflux esophagitis for which she was taking omeprazole.
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Helen Carnaghan, Hugh Warren, Andrew Douds Tags: Clinical Challenges and Images in GI Source Type: journals
Recalcitrant Vomiting, Disturbed Eye Movements, and LeukoencephalopathyEmail this article to a colleague.
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Question: A 34-year-old woman was referred for workup of severe cachexia (26 kg, 160 cm; body mass index, 10.2 kg/m2; highest weight, 40 kg), new-onset intractable vomiting and upper abdominal pain. She had initially undergone operative exploration at another hospital owing to high-grade gastric and proximal small bowel dilatation on abdominal CT scan ( A). However, mechanical obstruction was excluded at surgery. On admission to our department, physical examination was pertinent for hyperactive bowel sounds and a scaphoid abdomen painful on gentle palpation. Neurological evaluation disclosed discrete bilateral ptosis with ...
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Vincent Zimmer, Anna Zimmer, Michio Hirano, Frank Lammert Tags: Clinical Challenges and Images in GI Source Type: journals
Antireflux Therapy in Asthma: Is There Any Role?Email this article to a colleague.
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American Lung Association Asthma Clinical Research Centers, Mastronarde JG, Anthonisen NR, Castro M, et al. (Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland). Efficacy of esomeprazole for treatment of poorly controlled asthma. N Engl J Med 2009;360:1487–1499.
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Gary W. Falk Tags: Selected Summaries Source Type: journals
Prescribing an Antibiotic? Do Not Forget the ProbioticEmail this article to a colleague.
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Engelbrektson A, Korzenik JR, Pittler A, et al. (Environmental Biotechnology Institute, California Polytechnic State University, San Luis Obispo, California). Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapy. J Med Microbiol 2009;58:663–670.
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Raluca Vrabie, Faten N. Aberra Tags: Selected Summaries Source Type: journals
Globus Sensation and Hyperdynamic Upper Esophageal Sphincter: Another Piece in the Puzzle?Email this article to a colleague.
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Kwiatek MA, Mirza F, Kahrilas PJ, et al. (Division of Gastroenterology, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois). Hyperdynamic upper esophageal sphincter pressure: a manometric observation in patients reporting globus sensation. Am J Gastroenterol 2009;104:289–298.
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Hans–Dieter Allescher Tags: Selected Summaries Source Type: journals
Identification of Ferritin Receptors: Their Role in Iron Homeostasis, Hepatic Injury, and InflammationEmail this article to a colleague.
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Li JY, Paragas N, Ned RM, et al. (Renal Division, College of Physicians and Surgeons, Columbia University, New York, New York). Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Developmental Cell 2009;16:35–46.
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Grant A. Ramm, Richard G. Ruddell, V. Nathan Subramaniam Tags: Selected Summaries Source Type: journals
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This 200-page, hard-bound monograph is the latest contribution to Cambridge's Contemporary Issues in Cancer Imaging series. Each disease-specific volume brings together a multidisciplinary group of experts with the goals of educating diagnostic radiologists about current practice in tumor diagnosis, staging, and therapeutics, while updating treating physicians about the applications and limitations of recent advances in imaging science and technology.
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Michael C. Soulen Tags: Print and Media Reviews Source Type: journals
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This is an extensively revised and updated 2nd edition of a book initially published by Hans Beger and his colleagues in 1998. Many of the editors and authors of that earlier 2-volume edition have been replaced by new contributors and many new chapters have now been added to the text. The stated goal of this 2nd edition is “to provide the clinician with the most current … understanding of pancreatic diseases, functional assessments, diagnostic and technical devices, and treatment options.” To a great extent, this single-volume edition has achieved that goal. The book is composed of 104 chapters, grouped into 9 sectio...
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Michael L. Steer Tags: Print and Media Reviews Source Type: journals
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The overwhelming success of liver transplantation has led to a dramatic increase in its application. However, the diversity of the patient populations, the variability in the quality and types of donors, and the fluid nature of the specialty make clinical decision making in this specialty complex. Although there are numerous settings for sharing of experience at transplant and liver meetings worldwide and numerous textbooks that cover this shared experience with respect to liver transplantation, there are numerous areas within transplantation where agreement on management is not settled; even conventional immune suppressio...
Source: Gastroenterology - September 28, 2009 Category: Gastroenterology Authors: Ira J. Fox, Kyle A. Soltys Tags: Print and Media Reviews Source Type: journals
Outcomes of endoscopic resection of large colorectal neoplasms: An Australian experienceEmail this article to a colleague.
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Conclusion: Endoscopic resection of large colorectal neoplasms is safe and effective even for very large benign neoplasms. When the lesion is endoscopically resectable this should be the preferred treatment.
Source: Journal of Gastroenterology and Hepatology - September 27, 2009 Category: Gastroenterology Authors: Muna Salama, Donald Ormonde, Thai Quach, Hooi Ee, Ian Yusoff Source Type: journals
Baroreceptor sensitivity and baroreceptor effectiveness index in cirrhosis: the relevance of hepatic venous pressure gradientEmail this article to a colleague.
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Autonomic dysfunction has been reported as one of the complications of cirrhosis. The aim of this study was to test autonomic dysfunction in cirrhotic patients by analysing the baroreflex sensitivity and the baroreceptor effectiveness index (BEI), in order to determine its correlation with the severity and the aetiology of liver disease. Moreover, we explored the relationship between baroreceptor function and mortality in our cohort of patients. Clinical and laboratory evaluation, hepatic venous pressure gradient (HVPG) and haemodynamic setting and baroreceptor function were assessed in 45 cirrhotic patients (median age 55...
Source: Liver International - September 27, 2009 Category: Gastroenterology Authors: Simonetta Genovesi, Daniela M. Prata Pizzala, Massimo Pozzi, Laura Ratti, Maria Milanese, Antonio Vincenti, Andrea Stella, Giuseppe Mancia Source Type: journals
Gene expression profiling and functional assays of activated hepatic stellate cells suggest that myocardin has a role in activationEmail this article to a colleague.
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This study demonstrates that myocardin is involved in the activation of HSC; myocardin may serve as a novel therapeutic target in the treatment of liver fibrosis.
Source: Liver International - September 27, 2009 Category: Gastroenterology Authors: Hideaki Shimada, Takashi Ochi, Akira Imasato, Yoshihito Morizane, Masatoshi Hori, Hiroshi Ozaki, Katsuhiro Shinjo Source Type: journals
Localization of the lipopolysaccharide recognition complex in the human healthy and inflamed premature and adult gutEmail this article to a colleague.
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Microbiota in the intestinal lumen provide an abundant source of potentially detrimental antigens, including lipopolysaccharide (LPS), a potent immunostimulatory product of Gram-negative bacteria recognized by the host via TLR-4 and MD-2. An aberrant immune response to LPS or other bacterial antigens has been linked to inflammatory bowel disease (IBD) and necrotizing enterocolitis (NEC).We investigated which cells express MD-2 in the normal and inflamed ileum from neonates and adults by immunohistochemistry. Moreover, MD-2 and TLR4 mRNA expression in normal adult ileum was studied by reverse-transcription polymerase chain ...
Source: Inflammatory Bowel Diseases - September 27, 2009 Category: Gastroenterology Authors: Tim G.A.M. Wolfs, Joep P.M. Derikx, Caroline M.I.M. Hodin, Joris Vanderlocht, Ann Driessen, Adriaan P. de Bruïne, Charles L. Bevins, Felix Lasitschka, Nikolaus Gassler, Wim G. van Gemert, Wim A. Buurman Source Type: journals
Exam 1: Timing of Myelosuppression During Thiopurine Therapy for Inflammatory Bowel Disease: Implications for Monitoring RecommendationsEmail this article to a colleague.
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Source: Clinical Gastroenterology and Hepatology - September 27, 2009 Category: Gastroenterology Authors: C. Mel Wilcox Tags: CME Activities Source Type: journals
Exam 2: Fewer Polyps Detected by Colonoscopy as the Day Progresses at a Veteran's Administration Teaching HospitalEmail this article to a colleague.
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Source: Clinical Gastroenterology and Hepatology - September 27, 2009 Category: Gastroenterology Authors: C. Mel Wilcox Tags: CME Activities Source Type: journals
Short-term celecoxib to regress long-term persistent gastric intestinal metaplasia after Helicobacter pylori eradicationEmail this article to a colleague.
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Conclusion: Short-term celecoxib treatment can be safe and promising to regress long-term persistent IM after H. pylori eradication.
Source: Journal of Gastroenterology and Hepatology - September 26, 2009 Category: Gastroenterology Authors: Kuei-Hsiang Hung, Hsiao-Bai Yang, Hsiu-Chi Cheng, Jiunn-Jong Wu, Bor-Shyang Sheu Source Type: journals
Serum ornithine carbamyltransferase reflects hepatic damage in diabetic obese miceEmail this article to a colleague.
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Conclusions: Serum OCT seemed to reflect tumor necrosis factor-alpha-mediated hepatic damage when compared with ALT in diabetic obese mice and could be useful in the application for non-alcoholic fatty liver disease with features of metabolic syndrome, such as obesity and diabetes.
Source: Journal of Gastroenterology and Hepatology - September 26, 2009 Category: Gastroenterology Authors: Hiroshi Murayama, Masaki Ikemoto, Masaru Hamaoki Source Type: journals
Diagnostic role of serum glypican-3 in differentiating hepatocellular carcinoma from non-malignant chronic liver disease and other liver cancersEmail this article to a colleague.
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Conclusion: Serum GPC3 is highly specific for detecting HCC. The combined use of serum GPC3 and AFP provides a potentially promising tool to better differentiate HCC from benign liver disorders, as well as from other liver cancers.
Source: Journal of Gastroenterology and Hepatology - September 26, 2009 Category: Gastroenterology Authors: Pisit Tangkijvanich, Theerawut Chanmee, Sanpoj Komtong, Varocha Mahachai, Naruemon Wisedopas, Peraphan Pothacharoen, Prachya Kongtawelert Source Type: journals
Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-β/Smad in HepG2 cellEmail this article to a colleague.
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Conclusion: All these results suggest that CASE exerts anti-HepG2 cell invasion effect by modulating TGF-[beta]/Smad signaling.
Source: Journal of Gastroenterology and Hepatology - September 26, 2009 Category: Gastroenterology Authors: Xin Liu, Yan Yang, Xiaoxiang Zhang, Shengxin Xu, Shufang He, Weijuan Huang, Michael S Roberts Source Type: journals
Interstitial cells of Cajal are present in human extrahepatic bile ductsEmail this article to a colleague.
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Conclusion: This study demonstrates for the first time that ICC are present in human extrahepatic bile ducts where they are more densely aggregated than in the gallbladder. This cellular network is likely to be involved in biliary tract motility and its related disorders.
Source: Journal of Gastroenterology and Hepatology - September 26, 2009 Category: Gastroenterology Authors: Omid Ahmadi, Martha de L Nicholson, Maree L Gould, Allan Mitchell, Mark D Stringer Source Type: journals
Analysis of 3'-end variable region of the cagA gene in Helicobacter pylori isolated from Iranian populationEmail this article to a colleague.
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Conclusion: The structure of the 3' region of the cagA gene in Iranian strains was Western type. Although we could not find differences between EPIYA types and clinical outcomes, low prevalence of strains with multiple EPIYA-C segments might be reasons for low incidence of gastric cancer in Iran.
Source: Journal of Gastroenterology and Hepatology - September 26, 2009 Category: Gastroenterology Authors: Leila Shokrzadeh, Kaveh Baghaei, Yoshio Yamaoka, Hossein Dabiri, Fereshteh Jafari, Navid Sahebekhtiari, Ali Tahami, Mitsushige Sugimoto, Homayon Zojaji, Mohammad Reza Zali Source Type: journals
MicroRNA-224 is upregulated in HepG2 cells and involved in cellular migration and invasionEmail this article to a colleague.
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Conclusions: Overexpression of miR-224 was involved in the malignant phenotype of HepG2 cells, and it may be an important factor in regulating the migration and invasion of HepG2 cells.
Source: Journal of Gastroenterology and Hepatology - September 26, 2009 Category: Gastroenterology Authors: Qiong Li, Ge Wang, Jin-Lu Shan, Zhi-Xiang Yang, Hong-Zhong Wang, Jin Feng, Ji-Jun Zhen, Chuan Chen, Zhi-Min Zhang, Wen Xu, Xi-Zhong Luo, Dong Wang Source Type: journals
Usefulness of polyethylene glycol solution with dimethylpolysiloxanes for bowel preparation before capsule endoscopyEmail this article to a colleague.
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Conclusion: Bowel preparation using 1 L PEG with dimethylpolysiloxane 3 h before CE significantly reduced residue and intraluminal gas bubbles, and was considered to be a useful method for CE.
Source: Journal of Gastroenterology and Hepatology - September 26, 2009 Category: Gastroenterology Authors: Sadaharu Nouda, Eijiro Morita, Mitsuyuki Murano, Akira Imoto, Takanori Kuramoto, Takuya Inoue, Naoko Murano, Ken Toshina, Eiji Umegaki, Kazuhide Higuchi Source Type: journals
Chronic pancreatitis in Chinese children: Etiology, clinical presentation and imaging diagnosisEmail this article to a colleague.
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Conclusion: The main etiological factor of Chinese children with CP is idiopathic. The main symptom in these patients is multiple episodes of mild to moderate abdominal pain, which often lead to a delay in the definite diagnosis. CT and MRCP (or MRI) should be used as the first investigation in the evaluation of these cases.
Source: Journal of Gastroenterology and Hepatology - September 26, 2009 Category: Gastroenterology Authors: Wei Wang, Zhuan Liao, Zhao-Shen Li, Xin-Gang Shi, Luo-Wei Wang, Feng Liu, Ren-Pei Wu, Jian-Ming Zheng Source Type: journals
Usefulness of non-invasive markers for predicting liver cirrhosis in patients with chronic hepatitis BEmail this article to a colleague.
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Conclusion: The devised PAHA system was found to be useful for predicting the presence of liver cirrhosis in patients with chronic hepatitis B.
Source: Journal of Gastroenterology and Hepatology - September 26, 2009 Category: Gastroenterology Authors: Kwang Gyun Lee, Yeon Seok Seo, Hyonggin An, Soon Ho Um, Eun Suk Jung, Bora Keum, Hyung Joon Yim, Yoon Tae Jeen, Hoon Jai Chun, Chang Duck Kim, Ho Sang Ryu Source Type: journals
Association of exon 9 but not intron 8 VDR polymorphisms with occult HBV infection in south-eastern Iranian patientsEmail this article to a colleague.
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Conclusion: The polymorphisms in the T/T allele of exon 9 of VDR is possibly associated with OBI, thus it can be concluded that VDR and its functional polymorphisms are likely to be related to sensitivity and resistance of the immune system to HBV in OBI patients.
Source: Journal of Gastroenterology and Hepatology - September 26, 2009 Category: Gastroenterology Authors: Mohammad Kazemi Arababadi, Ali Akbar Pourfathollah, Abdollah Jafarzadeh, Gholamhossein Hassanshahi, Mohammad Ebrahim Rezvani Source Type: journals
Antioxidant therapy in the management of acute, chronic and post-ERCP pancreatitis: a systematic review.Email this article to a colleague.
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In conclusion, the present data do not support a benefit of antioxidant therapy alone or in combination with conventional therapy in the management of AP, CP or PEP. Further double blind, randomized, placebo-controlled clinical trials with large sample size need to be conducted.
PMID: 19777606 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 26, 2009 Category: Gastroenterology Authors: Mohseni Salehi Monfared SS, Vahidi H, Abdolghaffari AH, Nikfar S, Abdollahi M Tags: World J Gastroenterol Source Type: journals
Adenosine: an immune modulator of inflammatory bowel diseases.Email this article to a colleague.
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Inflammatory bowel disease (IBD) is a common and lifelong disabling gastrointestinal disease. Emerging treatments are being developed to target inflammatory cytokines which initiate and perpetuate the immune response. Adenosine is an important modulator of inflammation and its anti-inflammatory effects have been well established in humans as well as in animal models. High extracellular adenosine suppresses and resolves chronic inflammation in IBD models. High extracellular adenosine levels could be achieved by enhanced adenosine absorption and increased de novo synthesis. Increased adenosine concentration leads to acti...
Source: World Journal of Gastroenterology : WJG - September 26, 2009 Category: Gastroenterology Authors: Ye JH, Rajendran VM Tags: World J Gastroenterol Source Type: journals
Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells.Email this article to a colleague.
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CONCLUSION: Excess iron up-regulates HMOX1 and down-regulates HCV gene expression in hepatoma cells. This probably mitigates liver injury caused by combined iron overload and HCV infection.
PMID: 19777608 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 26, 2009 Category: Gastroenterology Authors: Hou WH, Rossi L, Shan Y, Zheng JY, Lambrecht RW, Bonkovsky HL Tags: World J Gastroenterol Source Type: journals
EGFR and HER2 expression in advanced biliary tract cancer.Email this article to a colleague.
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CONCLUSION: Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC, while targeting EGFR may be promising.
PMID: 19777609 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 26, 2009 Category: Gastroenterology Authors: Harder J, Waiz O, Otto F, Geissler M, Olschewski M, Weinhold B, Blum HE, Schmitt-Graeff A, Opitz OG Tags: World J Gastroenterol Source Type: journals
Protein interaction network related to Helicobacter pylori infection response.Email this article to a colleague.
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CONCLUSION: Immune-related proteins activated by H pylori infection interact with proto-oncogene proteins. The hub and bottleneck proteins are potential drug targets for gastric inflammation and cancer.
PMID: 19777610 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 26, 2009 Category: Gastroenterology Authors: Kim KK, Kim HB Tags: World J Gastroenterol Source Type: journals
