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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

NY-ESO-1 antibody as a novel tumour marker of gastric cancer
S Takiguchi, E Nakayama, M Mori & Y Doki
Source: British Journal of Cancer AOP - February 12, 2013 Category: Cancer & Oncology Authors: S FujiwaraH WadaJ KawadaR KawabataT TakahashiJ FujitaT HiraoK ShibataY MakariS IijimaH NishikawaA A JungbluthY NakamuraY KurokawaM YamasakiH MiyataK NakajimaS TakiguchiE NakayamaM MoriY Doki Source Type: research

Study shows long-term success rates for eradication of Barrett's esophagus after endoluminal therapies
(American Society for Gastrointestinal Endoscopy) A new study from researchers at the Hospital of the University of Pennsylvania reports that endoluminal (endoscopic) therapies, combining resection and ablation techniques, for patients with Barrett's esophagus and high-grade dysplasia or early mucosal cancer have a high success rate, with durable results and a low risk of complications. The researchers noted that endoscopic surveillance after successful eradication is required.
Source: EurekAlert! - Medicine and Health - February 12, 2013 Category: Global & Universal Source Type: news

History of GERD in the Community and Its Effect on SurvivalHistory of GERD in the Community and Its Effect on Survival
What are some of the most common symptoms of GERD, and how do their severity affect survival in patients? Alimentary Pharmacology & Therapeutics
Source: Medscape Today Headlines - February 11, 2013 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Norovirus easy to catch, hard to kill
ATLANTA, Feb. 11 (UPI) -- Norovirus, incorrectly called the "stomach flu," and technically known as viral gastroenteritis, is appearing across the United States, health officials say.
Source: Health News - UPI.com - February 11, 2013 Category: Consumer Health News Source Type: news

UCC team discovers tummy bug clue
Researchers in Cork have made important discoveries about how the immune system works during gastro-intestinal infections.
Source: The Irish Times - Health - February 11, 2013 Category: Consumer Health News Source Type: news

Confirming nasogastric feeding tube position versus the need to feed
Conclusions and recommendations: Research is urgently required on how to avoid tube misplacement. This must be balanced against risk of delayed feeding and cumulative nutritional deficit leading to subsequent complications and mortality.
Source: Intensive and Critical Care Nursing - February 11, 2013 Category: Nursing Authors: Stephen J. Taylor Tags: Review Source Type: research

The Future of Minimally Invasive Colorectal Surgery
What will the future hold for minimally invasive colorectal surgery? Colorectal surgeons have been at the forefront of technological progress of this field dating back to the development of endoscopic polypectomy. Progress in laparoscopic and natural orifice transluminal endoscopic surgeries has pointed toward the path to the future. Endoluminal surgery—operating within the lumen of the colon and rectum—exists in the transanal endoscopic microsurgery experience. Transluminal surgery—operating in the abdomen through the wall of another organ—is ideally suited to the colorectum, where the organ of access is also the ...
Source: Seminars in Colon and Rectal Surgery - February 11, 2013 Category: Gastroenterology Authors: John H. Marks, Matthew G. Mullen, Dominique N. McKeever, Daniel Benchimol Tags: The Evolution of Minimally Invasive Colorectal Surgery Source Type: research

Simulation and Minimally Invasive Colorectal Surgery
This article will review the use of simulation in minimally invasive colorectal surgery, including laparoscopy, single-incision laparoscopic surgery, robotic surgery, transanal endoscopic surgery, and finally, natural orifice transluminal endoscopy surgery. The role of simulation in surgical board certification and maintenance of certification will also be discussed.
Source: Seminars in Colon and Rectal Surgery - February 11, 2013 Category: Gastroenterology Authors: Sandra de Montbrun, Helen MacRae Tags: The Evolution of Minimally Invasive Colorectal Surgery Source Type: research

Barriers to Implementation
Despite multiple publications reporting the benefits of a minimally invasive approach, less than one-third of colectomies are being performed laparoscopically. Barriers include a wide array of factors ranging from lack of institutional support and equipment to a lack of experience and expertise. Overcoming the barriers to adoption of laparoscopic colectomy remains possible. Continued improvement in equipment will diminish the learning curve and create more providers. Enhanced education will facilitate technique accrual and skill retention. This chapter will focus on the identification of barriers to laparoscopic colectomy ...
Source: Seminars in Colon and Rectal Surgery - February 11, 2013 Category: Gastroenterology Authors: Howard Ross Tags: The Evolution of Minimally Invasive Colorectal Surgery Source Type: research

Minimally Invasive Anorectal Surgery: From Parks Local Excision to Transanal Endoscopic Microsurgery to Transanal Minimally Invasive Surgery
Total mesorectal excision remains the preferred oncological treatment of tumors of the rectum, providing excellent cure rates and minimal local recurrence. Surgical advances have led to more sphincter-sparing procedures using coloanal anastomosis. However, abdominoperineal resection with permanent colostomy remains the most common procedure performed today for tumors of the distal rectum. In addition, even precise total mesorectal excision results in frequent incidence of sexual, urologic, and bowel dysfunction. Local excision has slowly gained popularity, but is still considered a substandard operation owing to higher rec...
Source: Seminars in Colon and Rectal Surgery - February 11, 2013 Category: Gastroenterology Authors: Matthew Albert, Sam Atallah, Sergio Larach, Teresa deBeche-Adams Tags: The Evolution of Minimally Invasive Colorectal Surgery Source Type: research

Understanding Outcomes of Minimally Invasive Colorectal Resections
After a period of relatively slow uptake, laparoscopic colorectal surgery is now broadly implemented, and novel tools and approaches continue to be introduced into specialty practice. Oncological and functional outcomes of laparoscopic colectomy appear to be equivalent to those of open surgery. Laparoscopy offers short-term recovery benefits, including less pain, earlier return of bowel function, and shorter hospital stay. In certain settings, it may even reduce costs. Unfortunately, validated metrics of technical performance, to enable meaningful credentialing or detailed comparisons of techniques, are lacking. In this re...
Source: Seminars in Colon and Rectal Surgery - February 11, 2013 Category: Gastroenterology Authors: Scott E. Regenbogen, Arden M. Morris Tags: The Evolution of Minimally Invasive Colorectal Surgery Source Type: research

The Evolution of Minimally Invasive Colorectal Surgery Combined Endoscopic–Laparoscopic Approaches
Patients with benign colon polyps that are not amenable to endoscopic removal traditionally have undergone colon resection. Although endoscopic mucosal and submucosal dissection has been described for these polyps, the technique is not widely available and does not provide a solution for certain polyps. Polyp removal using combined endo–laparoscopic techniques may be an effective alternative in select patients.
Source: Seminars in Colon and Rectal Surgery - February 11, 2013 Category: Gastroenterology Authors: Kelly A. Garrett, Sang W. Lee Tags: The Evolution of Minimally Invasive Colorectal Surgery Source Type: research

NOTES: What Is the Current Status and Will It Ever See the Light of Day?
Natural orifice translumenal endoscopic surgery (NOTES) is an emerging field within gastroenterology and gastrointestinal surgery, in which the surgeon accesses the peritoneal cavity through a hollow viscus and performs a diagnostic or therapeutic intervention. Introduction of this new field of endolumenal surgery has proceeded in a slow and careful manner. The most common NOTES procedure currently performed worldwide is a transvaginal cholecystectomy. Because of the concerns over bacterial contamination, transanal and transcolonic NOTES procedures are rarely performed. Current research in transanal NOTES procedures are co...
Source: Seminars in Colon and Rectal Surgery - February 11, 2013 Category: Gastroenterology Authors: Mark H. Whiteford, Lee L. Swanström Tags: The Evolution of Minimally Invasive Colorectal Surgery Source Type: research

Single-Port Laparoscopy: Market-Driven or True Advancement
This article will examine the issues and data surrounding SILS in an attempt to distinguish its true and potential benefits from those hyped by market-driven declarations.
Source: Seminars in Colon and Rectal Surgery - February 11, 2013 Category: Gastroenterology Authors: Virgilio George Tags: The Evolution of Minimally Invasive Colorectal Surgery Source Type: research

Laparoscopic and Robotic Colorectal Surgery: A Comparison and Contrast
Laparoscopic surgery is now considered by many experts as the approach of choice for the surgical treatment of both benign and malignant colonic diseases. In contrast, robotic-assisted laparoscopic surgery is gaining acceptance and use in the colorectal surgery field. Currently, enthusiasm for the robotic platform, as a minimally invasive approach, has gained most interest for cases involving rectal surgery and pelvic anatomy. The robotic technique offers enhanced optics and mechanical instrumentation, which were designed to greatly improve visualization, exposure, and dissection in confined spaces such as the pelvic cavit...
Source: Seminars in Colon and Rectal Surgery - February 11, 2013 Category: Gastroenterology Authors: Eric M. Haas, Rodrigo Pedraza Tags: The Evolution of Minimally Invasive Colorectal Surgery Source Type: research

Robotic Use in Colorectal Disease: A Critical Analysis
Laparoscopic surgery is widely accepted in colorectal surgery, with proven short-term benefits. Nevertheless, widespread adoption of this approach is far from being a reality in part due to some inherent technical limitations. Robotic technologies have been developed to overcome some of these shortcomings, and several authors have embraced it, strongly supporting the superiority of this approach compared with laparoscopy. However, as we await more robust data, the routine use of robotic technology for the treatment of colorectal diseases, outside of clinical trials currently under way, does not appear to be cost effective ...
Source: Seminars in Colon and Rectal Surgery - February 11, 2013 Category: Gastroenterology Authors: Marco Ettore Allaix, Alessandro Fichera Tags: The Evolution of Minimally Invasive Colorectal Surgery Source Type: research

The Role of Enhanced Recovery Pathways in the Setting of Minimally Invasive Colorectal Surgery
This article will review the role of ERPs in the setting of minimally invasive colorectal surgery.
Source: Seminars in Colon and Rectal Surgery - February 11, 2013 Category: Gastroenterology Authors: Deborah S. Keller, Conor P. Delaney Tags: The Evolution of Minimally Invasive Colorectal Surgery Source Type: research

The History of Minimally Invasive Surgery
This article summarizes the evolution of minimally invasive surgery in general and highlights the milestones specific to the field of colorectal surgery. Early endoscopy, conventional laparoscopy, hand-assisted surgery, single-incision surgery, natural orifice surgery, and robotic colorectal surgery are reviewed.
Source: Seminars in Colon and Rectal Surgery - February 11, 2013 Category: Gastroenterology Authors: Steven Lee-Kong, Daniel L. Feingold Tags: The Evolution of Minimally Invasive Colorectal Surgery Source Type: research

Preface
Dr Scott Steele and the authors of this edition of Seminars in Colorectal Surgery have produced an excellent review of the development of minimally invasive colorectal surgery and an assessment of future opportunities in the field. This work clearly defines the challenges faced with surgical paradigm shift, particularly when associated with significantly different technical skills and instrumentation. The timing for the release of this work is opportune, as it appears the Affordable Care Act will be adopted and we can expect a dramatic change in the value proposition for the delivery of medical and surgical care in the United States.
Source: Seminars in Colon and Rectal Surgery - February 11, 2013 Category: Gastroenterology Authors: Anthony J. Senagore Tags: The Evolution of Minimally Invasive Colorectal Surgery Source Type: research

Introduction
Evolution is most often simply a matter of time, and in surgery, that is no different. That is not to say that all changes are needed, or even helpful. Yet, many of the changes witnessed in the development and progression of minimally invasive colorectal surgery have played a large role in both minimizing morbidity and maximizing outcomes. Our goal in this volume was to examine the considerations, drawbacks, and advancements minimally invasive techniques have provided in the evaluation, management, and outcomes of colorectal surgery patients across a broad range of colorectal disease and procedures. To help understand wher...
Source: Seminars in Colon and Rectal Surgery - February 11, 2013 Category: Gastroenterology Authors: Scott R. Steele Tags: The Evolution of Minimally Invasive Colorectal Surgery Source Type: research

Contents
Source: Journal of Critical Care - February 11, 2013 Category: Gastroenterology Source Type: research

Biomarkers could be antidote to overdose overtreatment
Researchers have identified several biomarkers that can accurately predict acute liver injury after acetaminophen overdose.
Source: MedWire News - Gastroenterology - February 11, 2013 Category: Gastroenterology Source Type: news

Impact of laryngopharyngeal and gastroesophageal reflux on asthma control in children
Conclusions: The reflux symptom score and LPR disease index do not seem reliable to diagnose LPR and GER in children with asthma. The frequency of LPR and GER are independent of asthma control, atopy and long acting beta agonist usage.
Source: International Journal of Pediatric Otorhinolaryngology - February 11, 2013 Category: ENT & OMF Authors: Mehtap Kilic, Fadil Ozturk, Ozlem Kirmemis, Sinan Atmaca, Sukru Nail Guner, Gonul Caltepe, Recep Sancak, Ayhan Gazi Kalayci Tags: Research papers Source Type: research

A systematic review of paediatric foreign body ingestion: Presentation, complications, and management
Conclusion: Foreign body ingestion is a common paediatric problem. Batteries and sharp objects should be removed immediately to avoid complications while others can be observed for spontaneous passage. Endoscopy has a high success rate in removing ingested foreign bodies.
Source: International Journal of Pediatric Otorhinolaryngology - February 11, 2013 Category: ENT & OMF Authors: Shruti Jayachandra, Guy D. Eslick Tags: Review article Source Type: research

Baby's Gut Bacteria Guided by Mom's Choices (CME/CE)
(MedPage Today) -- Cesarean delivery and bottle feeding influence the gut microbiota in infants, researchers found.
Source: MedPage Today Gastroenterology - February 11, 2013 Category: Gastroenterology Source Type: news

Premalignant Conditions of the Esophagus: When to Follow Up?Premalignant Conditions of the Esophagus: When to Follow Up?
New guidelines delineate which patients do, and which do not, require follow-up after index examinations. Medscape Gastroenterology
Source: Medscape Today Headlines - February 11, 2013 Category: Consumer Health News Tags: Gastroenterology Slide/Lecture Presentation Source Type: news

Could This Patient Have 'Non-Celiac Gluten Sensitivity'?Could This Patient Have 'Non-Celiac Gluten Sensitivity'?
Increasing numbers of individuals are convinced that their gastrointestinal symptoms are caused by gluten -- and relieved by a gluten-free diet. Medscape Gastroenterology
Source: Medscape Today Headlines - February 11, 2013 Category: Consumer Health News Tags: Gastroenterology Ask the Expert Source Type: news

Stretta(R) Therapy for GERD Receives Strongest Recommendation in SAGES New Clinical Guideline
Quality of Evidence: (++++) Grade Recommendation: Strong (Highest) GREENWICH, Conn., Feb. 11, 2013 -- (Healthcare Sales & Marketing Network) -- Mederi Therapeutics Inc. today announced that the Society of American Gastrointestinal and Endoscopic Sur... Devices, GastroenterologyMederi Therapeutics, Stretta therapy, GERD , radiofrequency
Source: HSMN NewsFeed - February 11, 2013 Category: Pharmaceuticals Source Type: news

Junior Scientist Position: Study of the neurohormonal signals from the digestive tract in animal models with controlled intestinal microbiota, Paris, France
Via http://www.eurosciencejobs.comvery year, INRA seeks researchers from all disciplines to reinforce laboratory and fieldwork teams. The Institute is recruiting through open competitions and offering permanent positions. Object of research and skills: The research activities will deal with intestinal microbiota modulation of the signals that regulate food intake originating from the digestive tract. The scope of the research extends to obesity and other metabolic diseases. This requires expertise in animal physiology, specifically in gastro-intestinal physiology and neuro-endocrinology of the digestive tract in relation ...
Source: Society for Endocrinology - February 11, 2013 Category: Endocrinology Source Type: news

Colorectal Cancer Screening and Computerized Tomographic Colonography
A Comprehensive OverviewColorectal Cancer Screening and Computerized Tomographic Colonography: A Comprehensive Overview is an authoritative volume on CT colonography. Structured in a manner that will allow the reader to understand the practical and larger public health issues surrounding both CT colonography and CRC screening in general, the text is designed to reach a broad audience of specialist clinicians and ...
Source: Springer Medicine titles - February 11, 2013 Category: Databases & Libraries Tags: Gastroenterology Source Type: news

A Pill So People With Celiac Disease Can Eat Freely?
Title: A Pill So People With Celiac Disease Can Eat Freely?Category: Health NewsCreated: 2/8/2013 12:35:00 PMLast Editorial Review: 2/11/2013 12:00:00 AM
Source: MedicineNet Crohn's Disease General - February 11, 2013 Category: Gastroenterology Source Type: news

Evaluating the suitability of Hydrobia ulvae as a test species for sediment metal toxicity testing applying a tissue residue approach to metal mixtures in laboratory and field exposures.
In this study, the intertidal gastropod Hydrobia ulvae was used to evaluate its suitability as a test organism for assessing sediment metal toxicity. Toxicity tests were run with sediments spiked with copper, cadmium and zinc applied both as single metal and as a mixture to investigate toxicological interactions evaluating different lethal and sublethal effects. Dose-response relationships were constructed based both on tissue residue approach and particulate metal concentrations. Because metal-spiked sediments used in routine toxicity tests often do not exhibit the same adsorption/desorption kinetics as the natural sedime...
Source: Chemosphere - February 11, 2013 Category: Chemistry Authors: Campana O, Rodríguez A, Blasco J Tags: Chemosphere Source Type: research

Polybrominated diphenyl ethers in birds from Chongming Island, Yangtze estuary, China: Insight into migratory behavior.
Abstract Sum-PBDEs concentrations in shorebirds and Anatidae ducks muscles from Chongming Dongtan National Nature Reserve ranged from 21-324 to 14-159ngg(-1) lw, respectively. PBDEs were detected in muscles of all the studied species. Compared with flyways around the world, migratory waterbirds on the East Asian-Australasian flyway exhibited lower PBDEs burdens than those reported on Black Sea-Mediterranean flyway in Europe and Pacific, Atlantic, Mississippi flyway in North America. Residential Eurasian tree sparrow samples indicated few PBDE products were used in Chongming Island developed in the idea of world fam...
Source: Chemosphere - February 11, 2013 Category: Chemistry Authors: Huang K, Lin K, Guo J, Zhou X, Wang J, Zhao J, Zhou P, Xu F, Liu L, Zhang W Tags: Chemosphere Source Type: research

[Renal toxicity of anti-CEGF targeted therapies.]
The objective of these treatments is to block either circulating VEGF (bevacizumab; VEGF-Trap), or tyrosine kinase receptors (especially the VEGF receptor) (sorafenib, sunitinib, brivanib, imatinib, etc.). Indeed, VEGF stimulates endothelial cell proliferation and then tumour growth and metastasis. However, all these antiangiogenic drugs share similar side effects, most frequently gastrointestinal disturbance, skin toxicity and hypertension. Hypertension seems to be especially frequent in case of good response. Renal side effects have probably been underestimated in the first place and their exact frequency is not known, n...
Source: Nephrologie and Therapeutique - February 11, 2013 Category: Urology & Nephrology Authors: Vigneau C, Rioux-Leclercq N Tags: Nephrol Ther Source Type: research

Real-Time Multipoint Gastrointestinal 19-Fluorine Catheter Tracking.
CONCLUSION: The presented real-time 19F MR based framework for the tracking of 19F labeled devices is applicable to combined 19F and 1H MRI guidance of gastrointestinal devices in vivo. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc. PMID: 23400935 [PubMed - as supplied by publisher]
Source: Magnetic Resonance in Medicine - February 11, 2013 Category: Radiology Authors: Hahn T, Kozerke S, Schwizer W, Fried M, Boesiger P, Steingoetter A Tags: Magn Reson Med Source Type: research

Identification of Novel Drug Targets in Hpb38, Hpp12, Hpg27, Hpshi470, Hpsjm180 Strains of Helicobacter Pylori: An In Silico Approach for Therapeutic Intervention.
Abstract Helicobacter species colonizes the stomach and are associated with the development of gastritis disease. Drugs for treatment of Helicobacter infection relieve pain or gastritis symptoms but they are not targeted specifically to Helicobacter pylori. Therefore, there is dire need for discovery of new drug targets and drugs for the treatment of H. pylori. The main objective of this study is to screen the potential drug targets by in silico analysis for the potent strains of H. pylori which include HpB38, HpP12, HpG27, Hpshi470 and HpSJM180. Genome and metabolic pathways of pathogen H. pylori and the host Homo...
Source: Current Drug Targets - February 11, 2013 Category: Drugs & Pharmacology Authors: Reddy NR, Pavani T Tags: Curr Drug Targets Source Type: research

Eicosanoid modulation by the short-chain fatty acid n-butyrate in human monocytes.
CONCLUSIONS: Our results suggest that among many other mediators of eicosanoid signalling n-butyrate massively induces PGE2 production by increasing the expression of PTGS2 (COX-2) in monocytes following TLR-4 and TLR-2 activation and induces secretion of LTB4 and TXB2. This underscores the role of n-butyrate as a crucial mediator of gut specific immunity. © 2013 The Authors. Immunology © 2013 Blackwell Publishing Ltd. PMID: 23398566 [PubMed - as supplied by publisher]
Source: Immunology - February 11, 2013 Category: Allergy & Immunology Authors: Kovarik JJ, Hölzl MA, Hofer J, Waidhofer-Söllner P, Sobanov Y, Koeffel R, Saemann MD, Mechtcheriakova D, Zlabinger GJ Tags: Immunology Source Type: research

Management options for aorto- oesophageal fistula: case histories and review of the literature.
CONCLUSIONS: Eliminating the source of bleeding as an emergency, resecting the oesophagus urgently to prevent sepsis and reconstructing the gastrointestinal continuity as an elective case after having the inflammatory processes settled seems to justify the endovascular aortic repair and subtotal oesophageal resection, followed by a gastro-oesophageal reconstruction, as an effective surgical approach. PMID: 23401340 [PubMed - as supplied by publisher]
Source: Perfusion - February 11, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Göbölös L, Miskolczi S, Pousios D, Tsang G, Livesey S, Barlow C, Kaarne M, Shambrook J, Lipnevicius A, Ohri S Tags: Perfusion Source Type: research

Essential role of the electroneutral Na+HCO3- cotransporter NBCn1 in murine duodenal acid/base balance and colonic mucus layer build-up in vivo.
This study investigated the significance of the electroneutral Na(+)HCO(3)(-) cotransporter NBCn1 for duodenal defence against acid and colonic mucus release. NBCn1 was localised to the basolateral membrane of duodenal villous enterocytes and of colonic crypt cells with a goblet cell predominant expression. Duodenal villous enterocyte pHi was studied before and during a luminal acid load by two-photon microscopy in exteriorised, vascularly perfused, indicator (SNARF-1 AM)-loaded duodenum of isoflurane-anaesthetised, systemic acid/base controlled mice. Acid-induced HCO(3)(-) secretion was measured in vivo by single-pass per...
Source: The Journal of Physiology - February 11, 2013 Category: Physiology Authors: Singh AK, Xia W, Riederer B, Juric M, Li J, Zheng W, Cinar A, Xiao F, Bachmann O, Song P, Praetorius J, Aalkjaer C, Seidler U Tags: J Physiol Source Type: research

Hepatocellular Carcinoma: Imaging Patterns on Gadoxetic Acid-enhanced MR Images and Their Value as an Imaging Biomarker [Gastrointestinal Imaging]
The signal intensity of hepatocellular carcinoma on hepatobiliary phase gadoxetic acid–enhanced MR images may be a useful imaging biomarker associated with tumor recurrence after surgery.
Source: Continuous Publishing articles - February 11, 2013 Category: Radiology Authors: Choi, J. W., Lee, J. M., Kim, S. J., Yoon, J.-H., Baek, J. H., Han, J. K., Choi, B. I. Tags: Gastrointestinal Radiology Gastrointestinal Imaging Source Type: research

Bladder and bowel dysfunction and the resolution of urinary incontinence with successful management of bowel symptoms in children
ConclusionsThe empirical treatment approach of managing bowel symptoms before intervening for bladder dysfunction in children with BBD is found to be appropriate.
Source: Acta Paediatrica - February 11, 2013 Category: Pediatrics Authors: Luise Borch, Søren Hagstroem, Wendy F Bower, Charlotte Siggaard Rittig, Søren Rittig Tags: Regular Article Source Type: research

Relative bioavailability and comparative clinical efficacy of different ivermectin oral formulations in lambs
Background: Several oral ivermectin (IVM) formulations for use in sheep are available in the pharmaceutical veterinary market in different countries. All of them are indicated at the same dose rate to treat the gastrointestinal nematodes. However, there is a lack of information on the relative systemic exposure (plasma bioavailability) and clinical efficacy among oral formulations routinely used in sheep. The main goal of the work reported here was to perform a pharmaco-parasitological assessment of three different IVM oral formulations in lambs infected with multiple resistant gastrointestinal nematodes. The comparative d...
Source: BMC Veterinary Research - Latest articles - February 11, 2013 Category: Veterinary Research Authors: Gonzalo SuárezLuis AlvarezDaniel CastellsOscar CorreaPietro FagiolinoCarlos Lanusse Source Type: research

Protective effects of Lactobacillus rhamnosus GG against human rotavirus‐induced diarrhea in a neonatal mouse model
This study here demonstrated that the protective effects of LGG against RV‐induced diarrhea were highly correlated with the timing and dosage of administering LGG, and intragastric administering 2×109 CFU LGG four consecutive days before RV‐infection here may be one of the most effective treatment options against RV‐induced diarrhea in neonatal mice. © 2013 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
Source: FEMS Immunology and Medical Microbiology - February 11, 2013 Category: Microbiology Authors: Zhen Zhang, Yun Xiang, Na Li, Baoxiang Wang, Hongwu Ai, Xiaomei Wang, Laiqiang Huang, Yi Zheng Tags: Research Paper Source Type: research

A case of cough and breathlessness
GE: A 64-year-old man never smoker with a history of dyspnoea and cough was referred for a respiratory opinion. The cough was sporadic but progressive over a 9 month period. It was associated with unpredictable, brief nocturnal paroxysms of breathlessness. There were also coughing bouts associated with phonation and with meals but no sputum production, fever or weight loss. There was no significant past medical history and he was not taking any medication. Physical examination was unremarkable. IM: This gentleman presents with a chronic, non-productive cough and episodic breathlessness. The duration of his symptoms ma...
Source: Thorax - February 11, 2013 Category: Respiratory Medicine Authors: Esterbrook, G., Molyneux, I., Clark, A. L., Morice, A. H. Tags: Lung neoplasms, Therapeutic trials, Lung cancer (oncology), Screening (oncology), Venous thromboembolism, Airway biology, Asthma, Lung cancer (respiratory medicine), Interstitial lung disease, Lung function, Pulmonary embolism, Radiology (diagnostics), He Source Type: research

Real‐Time Multipoint Gastrointestinal 19‐Fluorine Catheter Tracking
ConclusionThe presented real‐time 19F MR based framework for the tracking of 19F labeled devices is applicable to combined 19F and 1H MRI guidance of gastrointestinal devices in vivo. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc.
Source: Magnetic Resonance in Medicine - February 11, 2013 Category: Radiology Authors: Tobias Hahn, Sebastian Kozerke, Werner Schwizer, Michael Fried, Peter Boesiger, Andreas Steingoetter Tags: Note Source Type: research

[Original Article] Life Course Study of the Etiology of Self-Reported Irritable Bowel Syndrome in the 1958 British Birth Cohort
Conclusions This is the first study to show a long-term prospective link between premorbid psychopathology and later self-reported IBS, in agreement with previous findings on chronic fatigue syndrome. There is no evidence that prospective measures of childhood adversity are risk markers for IBS, and there is weak evidence that prospective measures of childhood illness at 16 years are risk markers for IBS, differing to results from the same cohort for psychopathology, chronic fatigue syndrome, and chronic widespread pain. This study also does not replicate the findings of retrospective studies examining the etiology of IBS.
Source: Psychosomatic Medicine - February 11, 2013 Category: Psychiatry & Psychology Authors: Goodwin, L., White, P. D., Hotopf, M., Stansfeld, S. A., Clark, C. Tags: Gastrointestinal Original Article Source Type: research

ALS dysphagia pathophysiology: Differential botulinum toxin response
Conclusions: The significant improvement observed in patients with isolated UES dysfunction suggests that a different pathophysiology of ALS dysphagia predisposes patients to a different response to treatment with BoTox-A. This treatment may represent an alternative treatment to percutaneous endoscopic gastrostomy (PEG) or prolong PEG-free time. Classification of evidence: This study provides Class III evidence that botulinum is more effective at 2 and 4 weeks in improving dysphagia in patients with ALS with UES hyperactivity without LMN involvement (vs those with LMN involvement).
Source: Neurology - February 11, 2013 Category: Neurology Authors: Restivo, D. A., Casabona, A., Nicotra, A., Zappia, M., Elia, M., Romano, M. C., Alfonsi, E., Marchese-Ragona, R. Tags: Gastrointestinal, Botulinum toxin, Amyotrophic lateral sclerosis, EMG ARTICLE Source Type: research

Unplanned reoperation within 30 days of surgery for colorectal cancer in NHS Lanarkshire
ConclusionThe rate of unplanned reoperation in NHS Lanarkshire compares favourably to that of England however similar methodological problems exist. The accuracy of the data is dependent on coding and entry.© 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland
Source: Colorectal Disease - February 11, 2013 Category: Gastroenterology Authors: Stephen McSorley, Chloe Lowndes, Praveen Sharma, Angus Macdonald Tags: Original Article Source Type: research

Anal Mucosectomy for Haemorrhoids: Should we start to speak Chinese?
ConclusionsCPH32 required significantly less sutures for bleeding control along the stapler line after circular mucosectomy. However, operation time, rate of postoperative complications and patient satisfaction were similar in both groups.© 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland
Source: Colorectal Disease - February 11, 2013 Category: Gastroenterology Authors: Dindo Daniel, Dieter Hahnloser Tags: Original Article Source Type: research

Preliminary Outcome Of A Treatment Strategy Based On Perioperative Chemotherapy And Surgery In Patients With Locally Advanced Colon Cancer
ConclusionNeoadjuvant chemotherapy followed by surgery and chemotherapy for LACC is safe without apparent increase of early and median term complications.© 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland
Source: Colorectal Disease - February 11, 2013 Category: Gastroenterology Authors: J. Arredondo, C. Pastor, J. Baixauli, J. Rodríguez, I. González, C. Vigil, A. Chopitea, J.L Hernández‐Lizoáin Tags: Original Article Source Type: research