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Diversity of Cellulolytic Microbes and the Biodegradation of Municipal Solid Waste by a Potential StrainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Municipal solid waste contains high amounts of cellulose, which is an ideal organic waste for the growth of most of microorganism as well as composting by potential microbes. In the present study, Congo red test was performed for screening of microorganism, and, after selecting a potential strains, it was further used for biodegradation of organic municipal solid waste. Forty nine out of the 250 different microbes tested (165 belong to fungi and 85 to bacteria) produced cellulase enzyme and among these Trichoderma viride was found to be a potential strain in the secondary screening. During the biodegradation of organic was...
Source: Comparative and Functional Genomics - February 9, 2012 Category: Genetics & Stem Cells Source Type: research

Controversies in using urine samples for prostate cancer detection: PSA and PCA3 expression analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This work confirms that prostate massage is important before urine collection for gene expression analysis. Since PSA and PCA3 are prostate specific, it is necessary to promote the passage of cells from prostate to urinary tract, in order to detect these genetic markers in urine samples. (Source: International Braz J Urol)
Source: International Braz J Urol - February 9, 2012 Category: Urology & Nephrology Source Type: research

Reprogramming of prostate cancer‐associated stromal cells to embryonic stem‐likeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONSGenes of CP stromal cells could be fully inactivated by genetic reprogramming. As a consequence, the disease phenotype was ‘cured’. Prostate © 2012 Wiley Periodicals, Inc. (Source: The Prostate)
Source: The Prostate - February 9, 2012 Category: Urology & Nephrology Authors: Eneida F. VêncioAngelique M. NelsonChristopher CavanaughCarol B. WareDaniel G. MilllerJulio C.O. GarciaRicardo Z.N. VêncioMichelle A. LoprienoAlvin Y. Liu Tags: Original Article Source Type: research

Genetic Sequencing Of Patients To Guide Treatment For TuberculosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A gene that influences the inflammatory response to infection may also predict the effectiveness of drug treatment for a deadly form of tuberculosis. An international collaboration between researchers at the University of Washington in Seattle, Duke University, Harvard University, the Oxford University Clinical Research Unit in Vietnam and Kings College London reported these findings in the journal Cell... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 9, 2012 Category: Consumer Health News Tags: Tuberculosis Source Type: news

First European Clinical Practice Guidelines For Wilson's Disease Published By EASLEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The first European Clinical Practice Guidelines (CPGs) for the diagnosis and management of Wilson's disease are published by the European Association for the Study of the Liver (EASL) on the EASL website*.(1) Developed to assist physicians and healthcare providers in the clinical decision making process, the guidelines describe best practice for the diagnosis and treatment of patients with Wilson's disease -- a rare genetic(2) disorder that, if left untreated, is fatal... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 9, 2012 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news

Genetic Screening and Counseling: Family Medicine ObstetricsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews these concerns and provides a framework for training in family medicine obstetrics training. (Source: Primary Care: Clinics in Office Practice)
Source: Primary Care: Clinics in Office Practice - February 9, 2012 Category: Primary Care Authors: K.M. Rodney Arnold, Zachary B. Self Source Type: research

Heart Disease Risk May Be Tied to Y ChromosomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Men’s higher risk for heart may result in part from genetic variants on the one chromosome unique to men, researchers have found. (Source: NYT Health)
Source: NYT Health - February 9, 2012 Category: Consumer Health News Authors: By GINA KOLATA Tags: Heart Chromosomes Genetics and Heredity Lancet, The (Journal) Research Source Type: news

Potent antitumor activity of oncolytic adenovirus-mediated SOCS1 for hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
X Hu & C Qian (Source: Gene Therapy)
Source: Gene Therapy - February 9, 2012 Category: Genetics & Stem Cells Authors: L LiuW LiX WeiQ CuiW LouG WangX HuC Qian Tags: gene therapy of cancer oncolytic adenovirus SOCS1 hepatocellular carcinoma Source Type: research

Zinc-finger nucleases: looking toward translationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
p; D M Dudzinski (Source: Gene Therapy)
Source: Gene Therapy - February 9, 2012 Category: Genetics & Stem Cells Authors: N J PalpantD M Dudzinski Tags: genetic engineering bioethics gene transfer Source Type: research

Progress in gene therapy of dystrophic heart diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& D Duan (Source: Gene Therapy)
Source: Gene Therapy - February 9, 2012 Category: Genetics & Stem Cells Authors: Y LaiD Duan Tags: muscular dystrophy heart cardiomyopathy Duchenne muscular dystrophy dystrophin sarcoglycan Source Type: research

Combination gene therapy targeting on interleukin-1β and RANKL for wear debris-induced aseptic looseningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Combination gene therapy targeting on interleukin-1β and RANKL for wear debris-induced aseptic loosening Gene Therapy advance online publication, February 9, 2012. doi:10.1038/gt.2012.1 Authors: H Wang, T-H Jia, N Zacharias, W Gong, H-X Du, P H Wooley & S-Y Yang (Source: Gene Therapy)
Source: Gene Therapy - February 9, 2012 Category: Genetics & Stem Cells Authors: H WangT-H JiaN ZachariasW GongH-X DuP H WooleyS-Y Yang Tags: osteoclastogenesis periprosthetic osteolysis synergetic effects Source Type: research

Phylogeny of Galactolipid Synthase Homologs Together with their Enzymatic Analyses Revealed a Possible Origin and Divergence Time for Photosynthetic Membrane BiogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The photosynthetic membranes of cyanobacteria and chloroplasts of higher plants have remarkably similar lipid compositions. In particular, thylakoid membranes of both cyanobacteria and chloroplasts are composed of galactolipids, of which monogalactosyldiacylglycerol (MGDG) is the most abundant, although MGDG biosynthetic pathways are different in these organisms. Comprehensive phylogenetic analysis revealed that MGDG synthase (MGD) homologs of filamentous anoxygenic phototrophs Chloroflexi have a close relationship with MGDs of Viridiplantae (green algae and land plants). Furthermore, analyses for the sugar specificity and...
Source: DNA Research - February 9, 2012 Category: Genetics & Stem Cells Authors: Yuzawa, Y., Nishihara, H., Haraguchi, T., Masuda, S., Shimojima, M., Shimoyama, A., Yuasa, H., Okada, N., Ohta, H. Tags: Full papers Source Type: research

Preferential Nucleosome Occupancy at High Values of DNA Helical RiseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nucleosomes are the basic structural units of eukaryotic chromatin and play a key role in the regulation of gene expression. Nucleosome formation depends on several factors, including properties of the sequence itself, but also physical constraints and epigenetic factors such as chromatin-remodelling enzymes. In this view, a sequence-dependent approach is able to capture a general tendency of a region to bind a histone octamer. A reference data set of positioned nucleosomes of Saccharomyces cerevisiae was used to study the role of DNA helical rise in histone–DNA interaction. Genomic sequences were transformed into ar...
Source: DNA Research - February 9, 2012 Category: Genetics & Stem Cells Authors: Pedone, F., Santoni, D. Tags: Full papers Source Type: research

Identification of Substrain-Specific Mutations by Massively Parallel Whole-Genome Resequencing of Synechocystis sp. PCC 6803Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The cyanobacterium, Synechocystis sp. PCC 6803, was the first photosynthetic organism whose genome sequence was determined in 1996 (Kazusa strain). It thus plays an important role in basic research on the mechanism, evolution, and molecular genetics of the photosynthetic machinery. There are many substrains or laboratory strains derived from the original Berkeley strain including glucose-tolerant (GT) strains. To establish reliable genomic sequence data of this cyanobacterium, we performed resequencing of the genomes of three substrains (GT-I, PCC-P, and PCC-N) and compared the data obtained with those of the original Kazu...
Source: DNA Research - February 9, 2012 Category: Genetics & Stem Cells Authors: Kanesaki, Y., Shiwa, Y., Tajima, N., Suzuki, M., Watanabe, S., Sato, N., Ikeuchi, M., Yoshikawa, H. Tags: Full papers Source Type: research

Diversity Array Technology Markers: Genetic Diversity Analyses and Linkage Map Construction in Rapeseed (Brassica napus L.)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We developed Diversity Array Technology (DArT) markers for application in genetic studies of Brassica napus and other Brassica species with A or C genomes. Genomic representation from 107 diverse genotypes of B. napus L. var. oleifera (rapeseed, AACC genomes) and B. rapa (AA genome) was used to develop a DArT array comprising 11 520 clones generated using PstI/BanII and PstI/BstN1 complexity reduction methods. In total, 1547 polymorphic DArT markers of high technical quality were identified and used to assess molecular diversity among 89 accessions of B. napus, B. rapa, B. juncea, and B. carinata collected from different p...
Source: DNA Research - February 9, 2012 Category: Genetics & Stem Cells Authors: Raman, H., Raman, R., Nelson, M. N., Aslam, M. N., Rajasekaran, R., Wratten, N., Cowling, W. A., Kilian, A., Sharpe, A. G., Schondelmaier, J. Tags: Full papers Source Type: research

Identification of Cis-Acting Promoter Elements in Cold- and Dehydration-Induced Transcriptional Pathways in Arabidopsis, Rice, and SoybeanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we performed microarray analyses using the three species, and compared characteristics of identified cold- and dehydration-inducible genes. Transcription profiles of the cold- and dehydration-responsive genes were similar among these three species, showing representative upregulated (dehydrin/LEA) and downregulated (photosynthesis-related) genes. All (46 = 4096) hexamer sequences in the promoters of the three species were investigated, revealing the frequency of conserved sequences in cold- and dehydration-inducible promoters. A core sequence of the abscisic acid-responsive element (ABRE) was the most conser...
Source: DNA Research - February 9, 2012 Category: Genetics & Stem Cells Authors: Maruyama, K., Todaka, D., Mizoi, J., Yoshida, T., Kidokoro, S., Matsukura, S., Takasaki, H., Sakurai, T., Yamamoto, Y. Y., Yoshiwara, K., Kojima, M., Sakakibara, H., Shinozaki, K., Yamaguchi-Shinozaki, K. Tags: Full papers Source Type: research

Discovery and mapping of a new expressed sequence tag-single nucleotide polymorphism and simple sequence repeat panel for large-scale genetic studies and breeding of Theobroma cacao L.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Theobroma cacao is an economically important tree of several tropical countries. Its genetic improvement is essential to provide protection against major diseases and improve chocolate quality. We discovered and mapped new expressed sequence tag-single nucleotide polymorphism (EST-SNP) and simple sequence repeat (SSR) markers and constructed a high-density genetic map. By screening 149 650 ESTs, 5246 SNPs were detected in silico, of which 1536 corresponded to genes with a putative function, while 851 had a clear polymorphic pattern across a collection of genetic resources. In addition, 409 new SSR markers were detected on ...
Source: DNA Research - February 9, 2012 Category: Genetics & Stem Cells Authors: Allegre, M., Argout, X., Boccara, M., Fouet, O., Roguet, Y., Berard, A., Thevenin, J. M., Chauveau, A., Rivallan, R., Clement, D., Courtois, B., Gramacho, K., Boland-Auge, A., Tahi, M., Umaharan, P., Brunel, D., Lanaud, C. Tags: Full papers Source Type: research

Mobilizing the Genome of Lepidoptera through Novel Sequence Gains and End Creation by Non-autonomous Lep1 HelitronsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transposable elements (TEs) can affect the structure of genomes through their acquisition and transposition of novel DNA sequences. The 134-bp repetitive elements, Lep1, are conserved non-autonomous Helitrons in lepidopteran genomes that have characteristic 5'-CT and 3'-CTAY nucleotide termini, a 3'-terminal hairpin structure, a 5'- and 3'-subterminal inverted repeat (SIR), and integrations that occur between AT or TT nucleotides. Lep1 Helitrons have acquired and propagated sequences downstream of their 3'-CTAY termini that are 57–344-bp in length and have termini composed of a 3'-CTRR preceded by a 3'-hairpin struct...
Source: DNA Research - February 9, 2012 Category: Genetics & Stem Cells Authors: Coates, B. S., Hellmich, R. L., Grant, D. M., Abel, C. A. Tags: Full papers Source Type: research

Assembly, Gene Annotation and Marker Development Using 454 Floral Transcriptome Sequences in Ziziphus Celata (Rhamnaceae), a Highly Endangered, Florida Endemic PlantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrates the efficacy of 454 transcriptome sequencing for rapid gene and marker discovery in an endangered plant. (Source: DNA Research)
Source: DNA Research - February 9, 2012 Category: Genetics & Stem Cells Authors: Edwards, C. E., Parchman, T. L., Weekley, C. W. Tags: Full papers Source Type: research

Role of transcriptional and post‐transcriptional regulation of methionine adenosyltransferases in liver cancer progressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we found for the first time a post‐transcriptional regulation of MAT1A and MAT2A by AUF1 and HuR in HCC. Low MATI/III:MATII ratio is a prognostic marker that contributes to determine a phenotype susceptible to HCC and patients' survival. Interference with cell cycle progression and IKK/NF‐kB signaling contributes to the anti‐proliferative and pro‐apoptotic effect of high SAM levels in HCC. (HEPATOLOGY 2012.) (Source: Hepatology)
Source: Hepatology - February 9, 2012 Category: Internal Medicine Authors: Maddalena FrauMaria L. TomasiMaria M. SimileMaria I. DemartisFabiana SalisGavinella LatteDiego F. CalvisiMaria A. SeddaiuLucia DainoClaudio F. FeoStefania BrozzettiGiuliana SolinasSatoshi YamashitaToshikazu UshijimaFrancesco FeoRosa M. Pascale Tags: Hepatobiliary Malignancies Source Type: research

Clinical and molecular characterization of Turkish patients with familial hypomagnesaemia: novel mutations in TRPM6 and CLDN16 genesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Among recently identified magnesium-wasting disorders, HSH and FHHNC represent two major entities also in the Turkish population. Besides clinical course and laboratory diagnosis of hypomagnesaemia, the detection of renal calcium wasting and parathyroid function are crucial to differentiate between these most prevalent forms of hereditary magnesium deficiency. While TRPM6 mutations underlying HSH almost uniformly lead to a complete loss of function of the TRPM6 protein, the severity of FHHNC phenotype depends on the residual function of the mutated claudin-16 protein. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - February 9, 2012 Category: Urology & Nephrology Authors: Guran, T., Akcay, T., Bereket, A., Atay, Z., Turan, S., Haisch, L., Konrad, M., Schlingmann, K. P. Tags: Chronic Kidney Disease Source Type: research

Hyaluronic Acid Enhances Gene Delivery into the CochleaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human Gene Therapy , Vol. 0, No. 0. (Source: Human Gene Therapy)
Source: Human Gene Therapy - February 8, 2012 Category: Genetics & Stem Cells Tags: article Source Type: research

Heart disease risk 'inherited'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists say a common heart disease which kills thousands each year is passed genetically from father to son. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - February 8, 2012 Category: Consumer Health News Source Type: news

Affymetrix stock down 10% after hours on Q4 earningsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Affymetrix Inc.'s stock was down nearly 10 percent after hours on Wednesday. It closed at $5.21 per share. The Santa Clara-based company (NASDAQ:AFFX) on Wednesday reported its fourth quarter earnings. Affymetrix makes products and services related to genetic analysis for the life science research and clinical health care markets. It reported a net loss of about $14.7 million, or 21 cents per diluted share, in the fourth quarter of 2011 compared to net income of $4 million, or 6 cents per diluted share, in the same period of 2010... (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - February 8, 2012 Category: Pharmaceuticals Source Type: research

Lab-Made Neurons Allow Scientists To Study A Genetic Cause Of Parkinson'sEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
By reverse engineering human skin cells to become induced pluripotent stem cells (iPSCs) and then coaxing them to become neural dopamine cells, scientists in the US have developed a way to study a genetic cause of Parkinson's disease in lab-made neurons. Their findings, which they write about in the 7 February issue of Nature Communications, reveal some potential new drug targets for Parkinson's and a new platform to screen treatments that might mimic the protective functions of parkin, the gene they investigated... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 8, 2012 Category: Consumer Health News Tags: Parkinson's Disease Source Type: news

Energy-Efficient Multi-Job Scheduling Model for Cloud Computing and Its Genetic AlgorithmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For the problem that the energy efficiency of the cloud computing data center is low, from the point of view of the energy efficiency of the servers, we propose a new energy-efficient multi-job scheduling model based on Google’s massive data processing framework. To solve this model, we design a practical encoding and decoding method for the individuals and construct an overall energy efficiency function of the servers as the fitness value of each individual. Meanwhile, in order to accelerate the convergent speed of our algorithm and enhance its searching ability, a local search operator is introduced. Finally, the exper...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research

Self-Optimization of Pilot Power in Enterprise Femtocells Using Multi objective HeuristicEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deployment of a large number of femtocells to jointly provide coverage in an enterprise environment raises critical challenges especially in future self-organizing networks which rely on plug-and-play techniques for configuration. This paper proposes a multi-objective heuristic based on a genetic algorithm for a centralized self-optimizing network containing a group of UMTS femtocells. In order to optimize the network coverage in terms of handled load, coverage gaps, and overlaps, the algorithm provides a dynamic update of the downlink pilot powers of the deployed femtocells. The results demonstrate that the algorithm can ...
Source: Advances in Pharmacological Sciences - February 8, 2012 Category: Drugs & Pharmacology Source Type: research

Hepatic Gene Transfer in Neonatal Mice by Adeno-Associated Virus Serotype 8 VectorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human Gene Therapy , Vol. 0, No. 0. (Source: Human Gene Therapy)
Source: Human Gene Therapy - February 8, 2012 Category: Genetics & Stem Cells Tags: article Source Type: research

Consumers want tougher probe of engineered salmonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
WASHINGTON (Reuters) - Three consumer groups petitioned the Food and Drug Administration on Tuesday to subject a new genetically engineered salmon to a more rigorous review process than is now in place before the fish can be approved as safe to eat. (Source: Reuters: Health)
Source: Reuters: Health - February 8, 2012 Category: Consumer Health News Tags: healthNews Source Type: news

Isolation of Human Islets for Autologous Islet Transplantation in Children and Adolescents with Chronic PancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present here a technical approach for the isolation and preservation of the islets proven to be efficient to obtain high numbers of islets, favoring the successful treatment of young patients. (Source: Anesthesiology Research and Practice)
Source: Anesthesiology Research and Practice - February 8, 2012 Category: Anesthesiology Source Type: research

Analysis of HLA‐DM polymorphisms in the Chinese Han populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study lays the foundations for further disease association analyses. (Source: Tissue Antigens)
Source: Tissue Antigens - February 8, 2012 Category: Allergy & Immunology Authors: M. L. FengR. Z. LiuT. ShenY. L. ZhaoZ. Y. ZhuD. Z. Liu Source Type: research

Spoon-feeding compared with 'baby-led' weaningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion While it was widely reported, this small cross-sectional study proves very little about the possible impact of different weaning methods on children’s food preferences, BMI or other health outcomes. Instead, because of its cross-sectional design, it can provide only a snapshot of all these factors (as reported by parents) at one point in time. It cannot show, for example, that babies who prefer carbohydrates do so because they were weaned on finger foods, as some news sources have reported. Many factors can affect a child’s food preferences and BMI, including genetic factors, exercise and social and demograp...
Source: NHS News Feed - February 8, 2012 Category: Consumer Health News Tags: Pregnancy/child Food/diet Source Type: news

Hope For Effective Endometriosis Screening Following Gene Mutation DiscoveryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers at Yale School of Medicine have, for the first time, described the genetic basis of endometriosis, a condition affecting millions of women that is marked by chronic pelvic pain and infertility. The researchers' discovery of a new gene mutation provides hope for new screening methods. Published in the early online issue of EMBO Molecular Medicine, the study explored an inherited mutation located in part of the KRAS gene, which leads to abnormal endometrial growth and endometrial risk... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 8, 2012 Category: Consumer Health News Tags: Women's Health / Gynecology Source Type: news

Molecular Link Established Between Genetic Defect And Heart MalformationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
UNC researchers have discovered how the genetic defect underlying one of the most common congenital heart diseases keeps the critical organ from developing properly. According to the new research, mutations in a gene called SHP-2 distort the shape of cardiac muscle cells so they are unable to form a fully functioning heart. The study also shows that treatment with a drug that regulates cell shape rescues the cardiac defect, pointing to therapeutic avenues that could one day benefit Noonan syndrome patients... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 8, 2012 Category: Consumer Health News Tags: Heart Disease Source Type: news

Anthrax Susceptibility Varies Between IndividualsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Susceptibility to anthrax toxin is a heritable genetic trait that may vary tremendously among individuals, according to a new study by researchers at the Stanford University School of Medicine. Among 234 people studied, the cells of three people were virtually insensitive to the toxin, while the cells of some people were hundreds of times more sensitive than those of others. The findings may have important implications for national security, as people known to be more resistant to anthrax exposure could be effective first-line responders in times of crises... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 8, 2012 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Parkinson's cells 'made in lab'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists in the US have successfully made human brain cells in the lab that are an exact replica of genetically caused Parkinson's disease. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - February 8, 2012 Category: Consumer Health News Source Type: news

Congenital heart defects in a novel recurrent 22q11.2 deletion harboring the genes CRKL and MAPK1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractThe proximal region of the long arm of chromosome 22 is rich in low copy repeats (LCR). Non‐allelic homologous recombination (NAHR) between these substrates explains the high prevalence of recurrent rearrangements within this region. We have performed array comparative genomic hybridization in a normally developing girl with growth delay, microcephaly, and truncus arteriosus, and have identified a novel recurrent 22q11 deletion that spans LCR22‐4 and partially affects the common 22q11.2 deletion syndrome and the distal 22q11 deletion syndrome. This deletion is atypical as it did not occur by NAHR between any of...
Source: American Journal of Medical Genetics Part A - February 8, 2012 Category: Genetics & Stem Cells Authors: Jeroen BreckpotBernard ThienpontMarijke BautersLeon‐Charles TrancheventMarc GewilligKarel AllegaertJoris R. VermeeschYves MoreauKoenraad Devriendt Tags: Research Article Source Type: research

Multiple meiotic errors caused by predivision of chromatids in women of advanced maternal age undergoing in vitro fertilisationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Joep Geraedts (Source: European Journal of Human Genetics)
Source: European Journal of Human Genetics - February 8, 2012 Category: Genetics & Stem Cells Authors: Alan H HandysideMarkus MontagM Cristina MagliSjoerd ReppingJoyce HarperAndreas SchmutzlerKaterina VeselaLuca GianaroliJoep Geraedts Tags: meiosis aneuploidy array comparative genomic hybridisation in vitro fertilisation polar body Source Type: research

The 12S rRNA A1555G mutation in the mitochondrial haplogroup D5a is responsible for maternally inherited hypertension and hearing loss in two Chinese pedigreesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Jianxin Lu & Min-Xin Guan (Source: European Journal of Human Genetics)
Source: European Journal of Human Genetics - February 8, 2012 Category: Genetics & Stem Cells Authors: Hong ChenJing ZhengLing XueYanzi MengYan WangBingjiao ZhengFang FangSuxue ShiQiaomeng QiuPingping JiangZhongqiu LuJun Qin MoJianxin LuMin-Xin Guan Tags: hypertension deafness mitochondrion 12S rRNA maternal inheritance Source Type: research

Proximal microdeletions and microduplications of 1q21.1 contribute to variable abnormal phenotypesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Arthur S Aylsworth (Source: European Journal of Human Genetics)
Source: European Journal of Human Genetics - February 8, 2012 Category: Genetics & Stem Cells Authors: Jill A RosenfeldRyan N TraylorG Bradley SchaeferElizabeth W McPhersonBlake C BallifEva KlopockiStefan MundlosLisa G ShafferArthur S Aylsworth Tags: 1q21.1 microdeletion microduplication TAR segmental duplication Source Type: research

Characterization of the intronic portion of cadherin superfamily members, common cancer orchestratorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Carla Oliveira (Source: European Journal of Human Genetics)
Source: European Journal of Human Genetics - February 8, 2012 Category: Genetics & Stem Cells Authors: Patrícia OliveiraRemo SangesDavid HuntsmanElia StupkaCarla Oliveira Tags: cadherin cancer intronic-based regulatory elements MIR MaLR transcription Source Type: research

Permutation-based approaches do not adequately allow for linkage disequilibrium in gene-wide multi-locus association analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Michael C O'Donovan (Source: European Journal of Human Genetics)
Source: European Journal of Human Genetics - February 8, 2012 Category: Genetics & Stem Cells Authors: Valentina MoskvinaKarl M SchmidtAlexey VedernikovMichael J OwenNicholas CraddockPeter HolmansMichael C O'Donovan Tags: gene-wide analysis correlated tests GWAS Source Type: research

C4ST-1/CHST11-controlled chondroitin sulfation interferes with oncogenic HRAS signaling in Costello syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
C4ST-1/CHST11-controlled chondroitin sulfation interferes with oncogenic HRAS signaling in Costello syndrome European Journal of Human Genetics advance online publication, February 8, 2012. doi:10.1038/ejhg.2012.12 Authors: Michael Klüppel, Payman Samavarchi-Tehrani, Kela Liu, Jeffrey L Wrana & Aleksander Hinek (Source: European Journal of Human Genetics)
Source: European Journal of Human Genetics - February 8, 2012 Category: Genetics & Stem Cells Authors: Michael KlüppelPayman Samavarchi-TehraniKela LiuJeffrey L WranaAleksander Hinek Tags: Costello syndrome HRAS C4ST-1 CHST11 chondroitin sulfate Source Type: research

An exploration of genetic health professionals' experience with direct-to-consumer genetic testing in their clinical practiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
amp; Jane L Halliday (Source: European Journal of Human Genetics)
Source: European Journal of Human Genetics - February 8, 2012 Category: Genetics & Stem Cells Authors: Gemma R BrettSylvia A MetcalfeDavid J AmorJane L Halliday Tags: direct-to-consumer health professional genetic testing genetic counsellor attitudes Source Type: research

Gross deletions in TCOF1 are a cause of Treacher–Collins–Franceschetti syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gross deletions in TCOF1 are a cause of Treacher–Collins–Franceschetti syndrome European Journal of Human Genetics advance online publication, February 8, 2012. doi:10.1038/ejhg.2012.2 Authors: Michael Bowman, Michael Oldridge, Caroline Archer, Anthony O'Rourke, Joanna McParland, Roel Brekelmans, Anneke Seller & Tracy Lester (Source: European Journal of Human Genetics)
Source: European Journal of Human Genetics - February 8, 2012 Category: Genetics & Stem Cells Authors: Michael BowmanMichael OldridgeCaroline ArcherAnthony O'RourkeJoanna McParlandRoel BrekelmansAnneke SellerTracy Lester Tags: TCOF1 Treacher–Collins–Franceschetti syndrome gene deletion mutation analysis LIS1 Source Type: research

Retrotransposon Ty1 integration targets specifically positioned asymmetric nucleosomal DNA segments in tRNA hotspots [RESEARCH]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Saccharomyces cerevisiae genome contains about 35 copies of dispersed retrotransposons called Ty1 elements. Ty1 elements target regions upstream of tRNA genes and other Pol III-transcribed genes when retrotransposing to new sites. We used deep sequencing of Ty1-flanking sequence amplicons to characterize Ty1 integration. Surprisingly, some insertions were found in mitochondrial DNA sequences, presumably reflecting insertion into mitochondrial DNA segments that had migrated to the nucleus. The overwhelming majority of insertions were associated with the 5' regions of Pol III transcribed genes; alignment of Ty1 insertion...
Source: Genome Research - February 8, 2012 Category: Genetics & Stem Cells Authors: Mularoni, L., Zhou, Y., Bowen, T., Gangadharan, S., Wheelan, S. J., Boeke, J. D. Tags: RESEARCH Source Type: research

Cell-type-specific nuclei purification from whole animals for genome-wide expression and chromatin profiling [METHOD]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the use of the method to isolate nuclei from muscle of adult Caenorhabditis elegans and from mesoderm of Drosophila melanogaster embryos. As a case study, we determined expression and nucleosome occupancy profiles for affinity-purified nuclei from C. elegans muscle. We identified hundreds of genes that are specifically expressed in muscle tissues and found that these genes are depleted of nucleosomes at promoters and gene bodies in muscle relative to other tissues. This method should be universally applicable to all model systems that allow transgenesis and will make it possible to determine epigenetic and expr...
Source: Genome Research - February 8, 2012 Category: Genetics & Stem Cells Authors: Steiner, F. A., Talbert, P. B., Kasinathan, S., Deal, R. B., Henikoff, S. Tags: METHOD Source Type: research

An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement [RESEARCH]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Developmental genes are regulated by complex, distantly located cis-regulatory modules (CRMs), often forming genomic regulatory blocks (GRBs) that are conserved among vertebrates and among insects. We have investigated GRBs associated with Iroquois homeobox genes in 39 metazoans. Despite 600 million years of independent evolution, Iroquois genes are linked to ankyrin-repeat-containing Sowah genes in nearly all studied bilaterians. We show that Iroquois-specific CRMs populate the Sowah locus, suggesting that regulatory constraints underlie the maintenance of the Iroquois–Sowah syntenic block. Surprisingly, tetrapod So...
Source: Genome Research - February 8, 2012 Category: Genetics & Stem Cells Authors: Maeso, I., Irimia, M., Tena, J. J., Gonzalez-Perez, E., Tran, D., Ravi, V., Venkatesh, B., Campuzano, S., Gomez-Skarmeta, J. L., Garcia-Fernandez, J. Tags: RESEARCH Source Type: research

Drosophila Genetic Reference Panel bridges genotype-phenotype gapEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Baylor College of Medicine News)
Source: Baylor College of Medicine News - February 8, 2012 Category: Universities & Medical Training Source Type: news

Outgrowth of single oncogene-expressing cells from suppressive epithelial environmentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Brugge Tumorigenesis is a clonal evolution process that is initiated from single cells within otherwise histologically normal tissue. It is unclear how single, sporadic mutant cells that have sustained oncogenic alterations evolve within a tightly regulated tissue environment. Here we investigated the effects of inducing oncogene expression in single cells in organotypic mammary acini as a model to elucidate the processes by which oncogenic alterations initiate clonal progression from organized epithelial environments. Sporadic cells induced to overexpress oncogenes that specifically perturb cell-cycle checkpoints (for exa...
Source: Nature AOP - February 8, 2012 Category: Research Authors: Cheuk T. LeungJoan S. Brugge Tags: Letter Source Type: research