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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

Analysis of CDS-located miRNA target sites suggests that they can effectively inhibit translation [RESEARCH]
Most of what is presently known about how miRNAs regulate gene expression comes from studies that characterized the regulatory effect of miRNA binding sites located in the 3' untranslated regions (UTR) of mRNAs. In recent years, there has been increasing evidence that miRNAs also bind in the coding region (CDS), but the implication of these interactions remains obscure because they have a smaller impact on mRNA stability compared with miRNA-target interactions that involve 3' UTRs. Here we show that miRNA-complementary sites that are located in both CDS and 3'-UTRs are under selection pressure and share the same sequence a...
Source: Genome Research - February 26, 2013 Category: Genetics & Stem Cells Authors: Hausser, J., Syed, A. P., Bilen, B., Zavolan, M. Tags: RESEARCH Source Type: research

A large-scale zebrafish gene knockout resource for the genome-wide study of gene function [RESOURCES]
With the completion of the zebrafish genome sequencing project, it becomes possible to analyze the function of zebrafish genes in a systematic way. The first step in such an analysis is to inactivate each protein-coding gene by targeted or random mutation. Here we describe a streamlined pipeline using proviral insertions coupled with high-throughput sequencing and mapping technologies to widely mutagenize genes in the zebrafish genome. We also report the first 6144 mutagenized and archived F1's predicted to carry up to 3776 mutations in annotated genes. Using in vitro fertilization, we have rescued and characterized ~0.5% ...
Source: Genome Research - February 26, 2013 Category: Genetics & Stem Cells Authors: Varshney, G. K., Lu, J., Gildea, D. E., Huang, H., Pei, W., Yang, Z., Huang, S. C., Schoenfeld, D., Pho, N. H., Casero, D., Hirase, T., Mosbrook-Davis, D., Zhang, S., Jao, L.-E., Zhang, B., Woods, I. G., Zimmerman, S., Schier, A. F., Wolfsberg, T. G., Pel Tags: RESOURCES Source Type: research

BCM genetics department hosts fifth annual high school educational genetics conference
Source: Baylor College of Medicine News - February 26, 2013 Category: Universities & Medical Training Source Type: news

Photocatalytically induced hydrophilicity influences bone remodelling at longer healing periods: a rabbit study
ConclusionsThe biologically enhancing effect to photocatalytically activated surfaces remained even after 12 weeks of healing time in terms of genetic responses.
Source: Clinical Oral Implants Research - February 26, 2013 Category: Dentistry Authors: M. Hayashi, R. Jimbo, Y. Xue, K. Mustafa, M. Andersson, A. Wennerberg Tags: Original Article Source Type: research

Genetic diversity and structure in Asian native goat analyzed by newly developed SNP markers
Abstract In the current study, a total of 65 single nucleotide polymorphisms (SNPs) within the intron region were developed in goat (Capra hircus) by utilizing genomic information of cattle and sheep due to poor available genomic information on goat. Using these markers, we carried out genetic diversity and structure analyses for 10 Asian goat populations. The phylogenetic tree and principal components analysis showed good correspondence between clustered populations and their geographic locations. The STRUCTURE software analysis illustrated six divergent genetic structures among 10 populations. Myanmar and Cambodia popula...
Source: Animal Science Journal - February 26, 2013 Category: Zoology Authors: Bang Zhong Lin, Taiki Kato, Makoto Kaneda, Hirokazu Matsumoto, Shinji Sasazaki, Hideyuki Mannen Tags: Original Article Source Type: research

Role of genetically engineered animals in future food production
Genetically engineered (GE) animals are likely to have an important role in the future in meeting the food demand of a burgeoning global population. There have already been many notable achievements using this technology in livestock, poultry and aquatic species. In particular, the use of RNA interference (RNAi) to produce virus‐resistant animals is a rapidly‐developing area of research. However, despite the promise of this technology, very few GE animals have been commercialised. This review aims to provide information so that veterinarians and animal health scientists are better able to participate in the debate on GE animals.
Source: Australian Veterinary Journal - February 26, 2013 Category: Veterinary Research Authors: KA McColl, B Clarke, TJ Doran Tags: REVIEW Source Type: research

Predictability of gene ontology slim-terms from primary structure information in Embryophyta plant proteins
Conclusions: An analysis of GO-slim terms predictability in plants was carried out, in order to determine singlecategories or groups of functions that are most related with primary structure information. For eachhighly predictable GO term, the responsible features of such successfulness were identified and discussed.In addition to most published studies, focused on few categories or single ontologies, resultsin this paper comprise a complete landscape of GO predictability from primary structure encompassing75 GO terms at molecular, cellular and phenotypical level. Thus, it provides a valuable guide forresearchers intereste...
Source: BMC Bioinformatics - Latest articles - February 26, 2013 Category: Bioinformatics Authors: Jorge Jaramillo-GarzónJoan Gallardo-ChacónCésar Castellanos-DomínguezAlexandre Prera-Lluna Source Type: research

A system for exact and approximate genetic linkage analysis of SNP data in large pedigrees
Source: Bioinformatics - February 26, 2013 Category: Bioinformatics Authors: Silberstein, M., Weissbrod, O., Otten, L., Tzemach, A., Anisenia, A., Shtark, O., Tuberg, D., Galfrin, E., Gannon, I., Shalata, A., Borochowitz, Z. U., Dechter, R., Thompson, E., Geiger, D. Tags: ERRATUM Source Type: research

Ascertaining the Role of Taiwan as a Source for the Austronesian Expansion
ABSTRACT Taiwanese aborigines have been deemed the ancestors of Austronesian speakers which are currently distributed throughout two‐thirds of the globe. As such, understanding their genetic distribution and diversity as well as their relationship to mainland Asian groups is important to consolidating the numerous models that have been proposed to explain the dispersal of Austronesian speaking peoples into Oceania. To better understand the role played by the aboriginal Taiwanese in this diaspora, we have analyzed a total of 451 individuals belonging to nine of the tribes currently residing in Taiwan, namely the Ami, Atay...
Source: American Journal of Physical Anthropology - February 26, 2013 Category: Physiology Authors: Sheyla Mirabal, Alicia M. Cadenas, Ralph Garcia‐Bertrand, Rene J. Herrera Tags: Research Article Source Type: research

Genetic Genealogy Comes of Age
ABSTRACT In this article, we promote the implementation of extensive genealogical data in population genetic studies. Genealogical records can provide valuable information on the origin of DNA donors in a population genetic study, going beyond the commonly collected data such as residence, birthplace, language, and self‐reported ethnicity. Recent studies demonstrated that extended genealogical data added to surname analysis can be crucial to detect signals of (past) population stratification and to interpret the population structure in a more objective manner. Moreover, when in‐depth pedigree data are combined with hap...
Source: American Journal of Physical Anthropology - February 26, 2013 Category: Physiology Authors: M.H.D. Larmuseau, A. Geystelen, M. Oven, R. Decorte Tags: Perspectives Source Type: research

Exploring prehistory in the North American southwest with mitochondrial DNA diversity exhibited by Yumans and Athapaskans
ABSTRACT A recent study of mitochondrial DNA variation in Native American populations from the American Southwest detected signatures of a population expansion of subhaplogroup B2a, dated to 2,105 years before present (99.5% confidence interval, 1,273–3,773 YBP), following the introduction and intensification of maize agriculture in the region. Only one Yuman group and no Athapaskan speakers were analyzed in previous studies. Here we report mtDNA haplogroup and hypervariable region (HVR I, and II) sequence data from 263 extant Yuman speakers, representing the major branches of the Yuman language family, in addition to th...
Source: American Journal of Physical Anthropology - February 26, 2013 Category: Physiology Authors: Cara Monroe, Brian M. Kemp, David Glenn Smith Tags: Research Article Source Type: research

Evidence for genetic differentiation in timing of maturation among nine‐spined stickleback populations
Abstract Timing of maturation is an important life‐history trait that is likely to be subjected to strong natural selection. Although population differences in timing of maturation have been frequently reported in studies of wild animal populations, little is known about the genetic basis of this differentiation. Here, we investigated population and sex differences in timing of maturation within and between two nine‐spined stickleback (Pungitius pungitius) populations in a laboratory breeding experiment. We found that fish from the high‐predation marine population matured earlier than fish from the low‐predation po...
Source: Journal of Evolutionary Biology - February 26, 2013 Category: Biology Authors: N. I. A. Ghani, G. Herczeg, T. Leinonen, J. Merilä Tags: Research Paper Source Type: research

Rivers, refuges and population divergence of fire‐eye antbirds (Pyriglena) in the Amazon Basin
Abstract The identification of ecological and evolutionary mechanisms that might account for the elevated biotic diversity in tropical forests is a central theme in evolutionary biology. This issue is especially relevant in the Neotropical region, where biological diversity is the highest in the world, but where few studies have been conducted to test factors causing population differentiation and speciation. We used mtDNA sequence data to examine the genetic structure within white‐backed fire‐eye (Pyriglena leuconota) populations along the Tocantins River valley in the south‐eastern Amazon Basin, and we confront the...
Source: Journal of Evolutionary Biology - February 26, 2013 Category: Biology Authors: M. Maldonado‐Coelho, J. G. Blake, L. F. Silveira, H. Batalha‐Filho, R. E. Ricklefs Tags: Research Paper Source Type: research

Hitchhiking to Speciation
by Daven C. Presgraves The modern evolutionary synthesis codified the idea that species exist as distinct entities because intrinsic reproductive barriers prevent them from merging together. Understanding the origin of species therefore requires understanding the evolution and genetics of reproductive barriers between species. In most cases, speciation is an accident that happens as different populations adapt to different environments and, incidentally, come to differ in ways that render them reproductively incompatible. As with other reproductive barriers, the evolution and genetics of interspecific hybrid sterility...
Source: PLoS Biology: Archived Table of Contents - February 26, 2013 Category: Biology Authors: Daven C. Presgraves Source Type: research

Indirect Evolution of Hybrid Lethality Due to Linkage with Selected Locus in Mimulus guttatus
by Kevin M. Wright, Deborah Lloyd, David B. Lowry, Mark R. Macnair, John H. Willis Most species are superbly and intricately adapted to the environments in which they live. Adaptive evolution by natural selection is the primary force shaping biological diversity. Differences between closely related species in ecologically selected characters such as habitat preference, reproductive timing, courtship behavior, or pollinator attraction may prevent interbreeding in nature, causing reproductive isolation. But does ecological adaptation cause reproductive incompatibilities such as hybrid sterility or lethality? Although se...
Source: PLoS Biology: Archived Table of Contents - February 26, 2013 Category: Biology Authors: Kevin M. Wright et al. Source Type: research

GBA increase improves PD & other synucleinopathies [Neuroscience]
Mutations of GBA1, the gene encoding glucocerebrosidase, represent a common genetic risk factor for developing the synucleinopathies Parkinson disease (PD) and dementia with Lewy bodies. PD patients with or without GBA1 mutations also exhibit lower enzymatic levels of glucocerebrosidase in the central nervous system (CNS), suggesting a possible link between...
Source: Proceedings of the National Academy of Sciences - February 26, 2013 Category: Science Authors: Sardi, S. P., Clarke, J., Viel, C., Chan, M., Tamsett, T. J., Treleaven, C. M., Bu, J., Sweet, L., Passini, M. A., Dodge, J. C., Yu, W. H., Sidman, R. L., Cheng, S. H., Shihabuddin, L. S. Tags: Biological Sciences Source Type: research

mtDNA haplogroup modulates ANT1 cardiomyopathy [Genetics]
Mutations of both nuclear and mitochondrial DNA (mtDNA)–encoded mitochondrial proteins can cause cardiomyopathy associated with mitochondrial dysfunction. Hence, the cardiac phenotype of nuclear DNA mitochondrial mutations might be modulated by mtDNA variation. We studied a 13-generation Mennonite pedigree with autosomal recessive myopathy and cardiomyopathy due to an SLC25A4 frameshift null...
Source: Proceedings of the National Academy of Sciences - February 26, 2013 Category: Science Authors: Strauss, K. A., DuBiner, L., Simon, M., Zaragoza, M., Sengupta, P. P., Li, P., Narula, N., Dreike, S., Platt, J., Procaccio, V., Ortiz–Gonzalez, X. R., Puffenberger, E. G., Kelley, R. I., Morton, D. H., Narula, J., Wallace, D. C. Tags: Biological Sciences Source Type: research

Aneuploidy in nascent allohexaploid wheat [Genetics]
We report here an in-depth investigation on transgenerational chromosomal variation in resynthesized allohexaploid...
Source: Proceedings of the National Academy of Sciences - February 26, 2013 Category: Science Authors: Zhang, H., Bian, Y., Gou, X., Zhu, B., Xu, C., Qi, B., Li, N., Rustgi, S., Zhou, H., Han, F., Jiang, J., von Wettstein, D., Liu, B. Tags: Biological Sciences Source Type: research

p53 and PARN deadenylase feedback loop [Biochemistry]
Although the p53 network has been intensively studied, genetic analyses long hinted at the existence of components that remained elusive. Recent studies have shown regulation of p53 at the mRNA level mediated via both the 5′ and the 3′ untranslated regions and affecting the stability and translation efficiency of the...
Source: Proceedings of the National Academy of Sciences - February 26, 2013 Category: Science Authors: Devany, E., Zhang, X., Park, J. Y., Tian, B., Kleiman, F. E. Tags: Biological Sciences Source Type: research

Animals in a bacterial world [Microbiology]
In the last two decades, the widespread application of genetic and genomic approaches has revealed a bacterial world astonishing in its ubiquity and diversity. This review examines how a growing knowledge of the vast range of animal–bacterial interactions, whether in shared ecosystems or intimate symbioses, is fundamentally altering our understanding...
Source: Proceedings of the National Academy of Sciences - February 26, 2013 Category: Science Authors: McFall–Ngai, M., Hadfield, M. G., Bosch, T. C. G., Carey, H. V., Domazet–Loso, T., Douglas, A. E., Dubilier, N., Eberl, G., Fukami, T., Gilbert, S. F., Hentschel, U., King, N., K&jnodot;elleberg, S., Knoll, A. H., Kremer, N., Mazmanian, S. K., Tags: Perspective Source Type: research

MSL complex in Drosophila [Genetics]
Dosage compensation is achieved in male Drosophila by a twofold up-regulation of the single X chromosome to reach the level of the two X chromosomes in females. A popular hypothesis to explain this phenomenon is that the male-specific lethal (MSL) complex, which is present at high levels on the male...
Source: Proceedings of the National Academy of Sciences - February 26, 2013 Category: Science Authors: Sun, L., Fernandez, H. R., Donohue, R. C., Li, J., Cheng, J., Birchler, J. A. Tags: PNAS Plus Source Type: research

In This Issue [This Week in PNAS]
Early-onset neurodegenerative disease linked to enzyme mutationCommon neurodegenerative disorders, such as Alzheimer’s and Parkinson diseases, begin in adulthood and are typically caused by a complex interaction of genetic and environmental factors. To pinpoint genes required for the maintenance of the central nervous system, Kaya Bilguvar et al. (pp. 3489–3494) studied...
Source: Proceedings of the National Academy of Sciences - February 26, 2013 Category: Science Tags: This Week in PNAS Source Type: research

Sodium transporter appears likely target for treating salt-sensitive hypertension
(Medical College of Georgia at Georgia Regents University) Genetics and demographics likely put you at risk for salt-sensitive hypertension, and scientists are looking for a way to protect you.
Source: EurekAlert! - Medicine and Health - February 26, 2013 Category: Global & Universal Source Type: news

Transcriptome analyses of primitively eusocial wasps reveal novel insights into the evolution of sociality and the origin of alternative phenotypes
An RNA-seq analysis of the genetic mechanisms controlling alternative phenotypes in the primitive eusocial wasp Polistes canadensis
Source: Genome Biology - February 26, 2013 Category: Genetics & Stem Cells Authors: Pedro FerreiraSolenn PatalanoRitika ChauhanRichard Ffrench-ConstantToni GabaldonRoderic GuigoSeirian Sumner Source Type: research

A CRISPR way to engineer the human genome
Srinivasan Chandrasegaran and colleagues explain how recent advances in mammalian genome engineering exploit the natural properties of the bacterial CRISPR system
Source: Genome Biology - February 26, 2013 Category: Genetics & Stem Cells Authors: Sivaprakash RamalingamNarayana AnnaluruSrinivasan Chandrasegaran Source Type: research

Massive screening of copy number population-scale variation in Bos taurus genome
Conclusions: This large scale screening significantly contributes to the enrichment of the Bos taurus CNV map, demonstrates the ubiquity, great diversity and complexity of this type of genomic variation and sets the basis for testing the influence of CNVs on Bos taurus complex functional and production traits.
Source: BMC Genomics - Latest articles - February 26, 2013 Category: Genetics & Stem Cells Authors: Francesco CicconardiGiovanni ChillemiAnna TramontanoCinzia MarchitelliAlessio ValentiniPaolo Ajmone-MarsanAlessandro Nardone Source Type: research

De novo assembly and characterization of transcriptome using Illumina paired-end sequencing and identification of CesA gene in ramie (Boehmeria nivea L. Gaud)
Conclusion: To the best of our knowledge, this study is the first to characterize the ramie transcriptome and the substantial amount of transcripts obtained will accelerate the understanding of the ramie vegetative growth and development mechanism. Moreover, discovery of the 36 CesA genes with relatively high expression levels in the stem bark will present an opportunity to understand the ramie bast fiber formation and development mechanisms.
Source: BMC Genomics - Latest articles - February 26, 2013 Category: Genetics & Stem Cells Authors: Liu ToumingZhu SiyuanTang QingmingChen PingYu YongtingTang Shouwei Source Type: research

Global analysis of transcriptional regulators in Staphylococcus aureus
Conclusions: The analysis presented herein highlights the complexity of regulatory networks in S. aureus strains, identifies key conserved TFs among the Staphylococacceae, and offers unique insights into several as yet uncharacterized TFs.
Source: BMC Genomics - Latest articles - February 26, 2013 Category: Genetics & Stem Cells Authors: Jose IbarraErnesto Pérez-RuedaRonan CarrollLindsey Shaw Source Type: research

Genetic analysis of the Trichuris muris-induced model of colitis reveals QTL overlap and a novel gene cluster for establishing colonic inflammation: Trichuris muris-induced colitis genetic study
Conclusion: Genetic susceptibility to induced colonic mucosal inflammation in the mouse is conserved at Tm3 and overlays Cdcs1.1. Genes central to the maintenance of intestinal homeostasis reside within this locus, implicating several candidates in susceptibility to colonic inflammation. Combined methodology incorporating genetic, transcriptional and pathway data allowed identification of biologically relevant candidate genes, with Vav3 newly implicated as a colitis susceptibility gene of functional relevance.
Source: BMC Genomics - Latest articles - February 26, 2013 Category: Genetics & Stem Cells Authors: Scott LevisonPaul FisherJenny HankinsonLeo ZeefSteve EyreWilliam OllierJohn McLaughlinAndy BrassRichard GrencisJoanne Pennock Source Type: research

A Poisson hierarchical modelling approach to detecting copy number variation in sequence coverage data
Conclusions: In summary, the proposed methodology brings an increase in flexibility, robustness, accuracy andstatistical rigour to CNV detection using sequence coverage data.
Source: BMC Genomics - Latest articles - February 26, 2013 Category: Genetics & Stem Cells Authors: Nuno SepúlvedaSusana CampinoSamuel AssefaColin SutherlandArnab PainTaane Clark Source Type: research

qDTY12.1: a locus with a consistent effect on grain yield under drought in rice
Conclusions: In this study, qDTY12.1 showed a consistent effect across environments for high grain yield under lowland reproductive-stage drought stress in the background of popular high-yielding but drought-susceptible recipient variety Sabitri. qDTY12.1 was also reported previously [Crop Sci 47:507--516, 2007] to increase grain yield under upland reproductive-stage drought stress situations. qDTY12.1 is the only QTL reported so far in rice to have shown a large effect against multiple recipient genetic backgrounds as well as under highly diverse upland and lowland rice ecosystems. qDTY12.1 can be successfully introgresse...
Source: BMC Genetics - Latest articles - February 26, 2013 Category: Genetics & Stem Cells Authors: Krishna MishraPrashant VikramRam YadawBP SwamyShalabh DixitMa CruzPaul MaturanShailesh MarkerArvind Kumar Source Type: research

Non‐parallel recombination limits cre‐loxP‐based reporters as precise indicators of conditional genetic manipulation
Abstract Cre/LoxP‐mediated recombination allows for conditional gene activation or inactivation. When combined with an independent lineage‐tracing reporter allele, this technique traces the lineage of presumptive genetically modified Cre‐expressing cells. Several studies have suggested that floxed alleles have differential sensitivities to Cre‐mediated recombination, which raises concerns regarding utilization of common Cre‐reporters to monitor recombination of other floxed loci of interest. Here, we directly investigate the recombination correlation, at cellular resolution, between several floxed alleles induced...
Source: genesis - February 26, 2013 Category: Genetics & Stem Cells Authors: Jing Liu, Spencer G. Willet, Eric D. Bankaitis, Yanwen Xu, Chris Wright, Guoqiang Gu Tags: Technology Report Source Type: research

The gene encoding the thioester‐containing protein, CPAMD8, is essential for construction of adult tissues in the chordate, Ciona intestinalis
SummaryThioester‐containing proteins (TEPs) constitute a conserved protein family among metazoans. They include immune system proteins alpha‐2‐macroglobulins (A2Ms) and complement C3. The protein PZP‐like A2M domain‐containing 8 (CPAMD8) is included in the A2M subfamily that has been found exclusively in deuterostomes. While involvement of CPAMD8 in the immune systems has been suggested, its function remains unknown. Here we show that the gene encoding CPAMD8 is essential for the development of adult tissues in the invertebrate chordate, Ciona intestinalis. In C. intestinalis, CPAMD8 is first expressed in the gil...
Source: genesis - February 26, 2013 Category: Genetics & Stem Cells Authors: Terumi Matsuoka, Satoko Awazu, Michio Ogasawara, Kazuo Inaba, Nori Satoh, Yasunori Sasakura Tags: Article Source Type: research

Reversible and tissue‐specific activation of MAP kinase signaling by tamoxifen in BrafV637ERT2 mice
Abstract Deregulated MAP kinase (MAPK) signaling plays key roles in developmental and adult disease processes but the experimental activation of MAPK is a currently unresolved task. For the reversible induction of MAPK signaling we generated transgenic mice harboring a tamoxifen inducible BRAFV637EERT2 fusion protein. The expression of the inducible BRAF kinase can be directed by Cre/loxP mediated recombination to selected cell types and enables the highly specific activation of MAPK signalling in vivo. We show that MAPK signaling can be transiently activated in the brain, liver or kidney of BrafV637EERT2 mice by a single ...
Source: genesis - February 26, 2013 Category: Genetics & Stem Cells Authors: Oskar Ortiz, Wolfgang Wurst, Ralf Kühn Tags: Technology Report Source Type: research

TET function in primordial germ cells
Nature Genetics 45, 233 (2013). doi:10.1038/ng.2577 Author: Emily Niemitz
Source: Nature Genetics - February 26, 2013 Category: Genetics & Stem Cells Authors: Emily Niemitz Tags: Research Highlights Source Type: research

Recurrent mutations in meningiomas
Nature Genetics 45, 233 (2013). doi:10.1038/ng.2576 Author: Kyle Vogan
Source: Nature Genetics - February 26, 2013 Category: Genetics & Stem Cells Authors: Kyle Vogan Tags: Research Highlights Source Type: research

Pigeon genome
Nature Genetics 45, 233 (2013). doi:10.1038/ng.2575 Author: Orli Bahcall
Source: Nature Genetics - February 26, 2013 Category: Genetics & Stem Cells Authors: Orli Bahcall Tags: Research Highlights Source Type: research

PKCζ is a metabolic tumor suppressor
Nature Genetics 45, 233 (2013). doi:10.1038/ng.2574 Author: Pamela Feliciano
Source: Nature Genetics - February 26, 2013 Category: Genetics & Stem Cells Authors: Pamela Feliciano Tags: Research Highlights Source Type: research

Oxytricha macronuclear genome
Nature Genetics 45, 233 (2013). doi:10.1038/ng.2573 Author: Pamela Feliciano
Source: Nature Genetics - February 26, 2013 Category: Genetics & Stem Cells Authors: Pamela Feliciano Tags: Research Highlights Source Type: research

Filling in the gaps in cranial suture biology
Nature Genetics 45, 231 (2013). doi:10.1038/ng.2557 Author: David R FitzPatrick Two new loci for premature fusion of the cranial sutures in humans suggest a common endpoint in osteoblast regulation, linking upregulation of phosphorylated ERK1/2 and TWIST1 haploinsufficiency.
Source: Nature Genetics - February 26, 2013 Category: Genetics & Stem Cells Authors: David R FitzPatrick Tags: News and Views Source Type: research

RNF212 marks the spot
Nature Genetics 45, 228 (2013). doi:10.1038/ng.2559 Authors: Cathleen M Lake & R Scott Hawley A new study in mice shows that, during meiosis, the decision to mature a double-strand break into a crossover is controlled by a dosage-sensitive regulator, RNF212. This finding provides insight into the crossover maturation process and may help explain how sequence polymorphisms in RNF212 alter the frequency of crossing over in humans.
Source: Nature Genetics - February 26, 2013 Category: Genetics & Stem Cells Authors: Cathleen M LakeR Scott Hawley Tags: News and Views Source Type: research

Broader and deeper
Nature Genetics 45, 227 (2013). doi:10.1038/ng.2580 Cancer genomes are now rapidly yielding to analysis, showing the heterogeneity of the mutational events and processes contributing to disease. This diversity is enormous and occurs at many levels. Consequently, the first clues from exome sequencing will increasingly need to be complemented by integrated analyses and extended to implicate mutations relevant to treatment outcomes.
Source: Nature Genetics - February 26, 2013 Category: Genetics & Stem Cells Tags: Editorial Source Type: research

Possible association between TGF‐β1 polymorphism and oral cancer
Summary Oral squamous cell carcinoma (OSCC) is a worldwide health problem because it is a great cause of cancer morbidity and mortality. The transforming growth factor‐β1 (TGF‐β1) is involved in the regulation of numerous immunomodulatory processes. Thus, the aim of this case–control study was to investigate the possible association between the TGF‐β1T869C polymorphism and oral cancer. The genomic DNA extracted from peripheral blood of 62 male smoker patients diagnosed with OSCC and 62 smokers without cancer was analysed. The C allele was significantly more prevalent in the oral cancer group than in the controls...
Source: International Journal of Immunogenetics - February 26, 2013 Category: Genetics & Stem Cells Authors: N. K. Carneiro, J. M. M. Oda, R. Losi Guembarovski, G. Ramos, B. V. Oliveira, I. J. Cavalli, E. M. S. F. Ribeiro, M. S. B. Gonçalves, M. A. E. Watanabe Tags: Original Article Source Type: research

Association of Interleukin 1 beta (IL‐1B) gene polymorphism with early pregnancy loss risk in the North Indian population
Summary C+3953T IL‐1 B single‐nucleotide polymorphism (SNP) genotyping was carried out in 140 unrelated early pregnancy loss (EPL) patients and in 198 fertile healthy control women and in chorionic villous samples by PCR‐RFLP. In Indian population, this is the first report on association of IL‐1 B SNP C+3953T polymorphism and EPL.
Source: International Journal of Immunogenetics - February 26, 2013 Category: Genetics & Stem Cells Authors: R. R. Nair, A. Khanna, K. Singh Tags: Short Communication Source Type: research

Nomenclature for factors of the HLA system, update October 2012
Source: International Journal of Immunogenetics - February 26, 2013 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Nomenclature for factors of the HLA system, update November 2012
Source: International Journal of Immunogenetics - February 26, 2013 Category: Genetics & Stem Cells Authors: S. G. E. Marsh Tags: Nomenclature Source Type: research

Newborn screening for lethal genetic disorder works
Study shows screening girls and boys helps detect and treat disorderRelated items from OnMedicaScreening test spots heart defects in babies Premature birth reduces brain ‘plasticity’Call for an upgrade in midwifery provisionHeavy babies risk rheumatoid arthritis in adulthoodBabies with cystic fibrosis live longer in the EU
Source: OnMedica Latest News - February 26, 2013 Category: UK Health Source Type: news

Aberrant wound healing in the horse: Naturally occurring conditions reminiscent of those observed in man
Abstract Impaired wound healing represents an enormous clinical and financial problem for companion animals and humans alike. Unfortunately, most models used to study healing rely on rodents, which have significant differences in the healing and scarring process and rarely develop complications. In order to better simulate impaired healing, the model should strive to reproduce the natural processes of healing and delayed healing. Wounds on the limbs of horses display similarities to wounds in humans in their epithelialization/contraction ratio, genetic influence as well as dysregulated cytokine profile and the spontaneous ...
Source: Wound Repair and Regeneration - February 26, 2013 Category: Surgery Authors: Christine L. Theoret, Jacintha M. Wilmink Tags: Perspective Article Source Type: research

U of M researchers identify genetic variation behind acute myeloid leukemia treatment success
(University of Minnesota Academic Health Center) Researchers from the College of Pharmacy and Medical School working within the Masonic Cancer Center, University of Minnesota, have partnered to identify genetic variations that may help signal which acute myeloid leukemia patients will benefit or not benefit from one of the newest antileukemic agents. Their study is published today in Clinical Cancer Research.
Source: EurekAlert! - Medicine and Health - February 26, 2013 Category: Global & Universal Source Type: news

Researchers find controlling element of Huntington's disease
(Helmholtz Association of German Research Centres) A three molecule complex may be a target for treating Huntington's disease, a genetic disorder affecting the brain. This finding by an international research team including scientists from the German Center for Neurodegenerative Diseases in Bonn and the University of Mainz was published today in the online journal Nature Communications.
Source: EurekAlert! - Medicine and Health - February 26, 2013 Category: Global & Universal Source Type: news