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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Acetaminophen-Related Liver Damage May Be Prevented By Common Herbal MedicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A well-known Eastern medicine supplement may help avoid the most common cause of liver transplantation, according to a study by researchers at the Stanford University School of Medicine. The finding came as a surprise to the scientists, who used a number of advanced genetic and genomic techniques in mice to identify a molecular pathway that counters acetaminophen toxicity, which leads to liver failure. (Source: Genetics News From Medical News Today)
Source: Genetics News From Medical News Today - November 18, 2009 Category: Genetics & Stem Cells Tags: Liver Disease / Hepatitis Source Type: news

Detection of chromosomal abnormalities associated with chronic lymphocytic leukemia: what is the best method?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: B-cell chronic lymphocytic leukemia (CLL) follows a heterogeneous clinical course, for which several biological markers may predict clinical outcome. Cytogenetic aberrations are considered major prognostic indicators for predicting the survival of CLL patients. Given the difficulties in obtaining abnormal metaphases in CLL, fluorescent in situ hybridization (FISH) with specific probes is generally used to detect the most frequent abnormalities. To determine the best strategy for identifying cytogenetic abnormalities, we compared results obtained by FISH analysis on peripheral blood mononuclear cells with those ob...
Source: Cancer Genetics and Cytogenetics - October 19, 2009 Category: Genetics & Stem Cells Authors: Maha el-Taweel, Carole Barin, Florence Cymbalista, Virginie Eclache Tags: Original articles Source Type: journals

New Biomarker Predicts Response To Hepatitis C TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers have identified the first genetic marker that predicts response to hepatitis C treatments, and a single letter of DNA code appears to make a huge difference. Duke University Medical Center scientists says the biomarker not only predicts who is most likely to respond to treatment and who isn't, but also may explain why there are such different rates of response among racial and ethnic groups, a phenomenon that has puzzled physicians for years. (Source: Genetics News From Medical News Today)
Source: Genetics News From Medical News Today - August 17, 2009 Category: Genetics & Stem Cells Tags: Liver Disease / Hepatitis Source Type: news

Estrogen And Progesterone Receptor Isoforms Expression In The Stomach Of Mongolian GerbilsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have previously shown that E2 and P4 have clear and distinct effects on inflammatory response and gastric epithelial changes during early H. pylori infection. Recently, Ohtani et al., have shown a protective role of E2 administration in H. pylori-infected InGas mice. Other studies have demonstrated that E2 and P4 have anti-ulcerative effects in murine gastric mucosa. ER and PR have been reported in human, mouse and rat stomachs. (Source: Genetics News From Medical News Today)
Source: Genetics News From Medical News Today - November 3, 2008 Category: Genetics & Stem Cells Tags: GastroIntestinal / Gastroenterology Source Type: news

Genes Involved In Antibiotic Resistance Vary Within A SpeciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The recent emergence of multidrug resistance (MDR) in Acinetobacter baumannii, a bacteria that causes infections primarily among seriously ill patients in the intensive care unit who may have reduced immune systems, has raised concern in health care settings worldwide. When comparing the genome sequence of three MDR A. baumannii isolates and three drug-susceptible A. (Source: Genetics News From Medical News Today)
Source: Genetics News From Medical News Today - December 19, 2008 Category: Genetics & Stem Cells Tags: Genetics Source Type: news

Large scale calcium channel gene rearrangements in episodic ataxia and hemiplegic migraine: implications for diagnostic testingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Large scale deletions and duplications can cause CACNA1A associated channelopathies. Direct DNA sequencing alone is not sufficient as a diagnostic screening test. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - October 30, 2009 Category: Genetics & Stem Cells Authors: Labrum, R W, Rajakulendran, S, Graves, T D, Eunson, L H, Bevan, R, Sweeney, M G, Hammans, S R, Tubridy, N, Britton, T, Carr, L J, Ostergaard, J R, Kennedy, C R, Al-Memar, A, Kullmann, D M, Schorge, S, Temple, K, Davis, M B, Hanna, M G Tags: Eye Diseases, Molecular genetics, Immunology (including allergy), Headache (including migraine), Epidemiology Mutation reports Source Type: journals

Bordetella pertussis and vaccination: the persistence of a genetically monomorphic pathogen.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Before childhood vaccination was introduced in the 1950s, pertussis or whooping cough was a major cause of infant death worldwide. Widespread vaccination of children was successful in significantly reducing morbidity and mortality. However, despite vaccination, pertussis has persisted and, in the 1990s, resurged in a number of countries with highly vaccinated populations. Indeed, pertussis has become the most prevalent vaccine-preventable disease in developed countries with estimated infection frequencies of 1%-6%. Recently vaccinated children are well protected against pertussis disease and its increase is mainly seen...
Source: Infection, Genetics and Evolution - October 29, 2009 Category: Genetics & Stem Cells Authors: Mooi FR Tags: Infect Genet Evol Source Type: journals

Establishment and conventional cytogenetic characterization of three gastric cancer cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Gastric cancer is the fourth most frequent type of cancer and the second most frequent cause of cancer mortality worldwide. Only a modest number of gastric carcinoma cell lines have been isolated thus far. Here we describe the establishment and cytogenetic characterization of three new gastric cancer cell lines obtained from primary gastric adenocarcinoma (ACP02 and ACP03) and cancerous ascitic fluid (AGP01) of individuals from northern Brazil. ACP02, ACP03, and AGP01 cell lines are presently in the 60th passage. The cell lines grew in a disorganized single layer with some agglomerations and heterogeneous divisio...
Source: Cancer Genetics and Cytogenetics - October 19, 2009 Category: Genetics & Stem Cells Authors: Mariana Ferreira Leal, José Luiz Martins do Nascimento, Carla Elvira Araújo da Silva, Maria Fernanda Vita Lamarão, Danielle Queiroz Calcagno, André Salim Khayat, Paulo Pimentel Assumpção, Isabel Rosa Cabral, Marília de Arruda Cardoso Smith, Rommel Tags: Short communications Source Type: journals

The lack of clinical distinction between the hypermobility type of Ehlers-Danlos syndrome and the joint hypermobility syndrome (a.k.a. hypermobility syndrome)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract. (Source: American Journal of Medical Genetics Part A)
Source: American Journal of Medical Genetics Part A - October 18, 2009 Category: Genetics & Stem Cells Authors: Brad T. Tinkle, Howard A. Bird, Rodney Grahame, Mark Lavallee, Howard P. Levy, David Sillence Source Type: journals

Age-Specific Evaluation Of HPV DNA Testing Vs. Cytology ScreeningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human papillomavirus (HPV) DNA testing with cytology triage is more sensitive than conventional cytology screening for detecting cervical lesions, according to a new study published online November 9 in the Journal of the National Cancer Institute. Cytology triage in HPV-positive women can improve specificity. (Source: Genetics News From Medical News Today)
Source: Genetics News From Medical News Today - November 10, 2009 Category: Genetics & Stem Cells Tags: Cervical Cancer / HPV Vaccine Source Type: news

Fusion of EWSR1 with the DUX4 facioscapulohumeral muscular dystrophy region resulting from t(4;22)(q35;q12) in a case of embryonal rhabdomyosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe here a case of embryonal RMS in a 19-year-old female patient. The conventional cytogenetic analysis showed a t(4;22)(q35;q12) translocation as the sole cytogenetic change. Complementary fluorescence in situ hybridization analysis showed that the translocation breakpoints were located in the EWSR1 gene at 22q12 and the region of the DUX4 and FSHMD1A at 4q35. This constitutes a novel example of the high frequency of EWSR1 rearrangements in various types of sarcomas as well as of its ability to fuse with a large variety of partner genes. Because DUX4 is involved in myogenic differentiation and cell-cycle control, ...
Source: Cancer Genetics and Cytogenetics - October 19, 2009 Category: Genetics & Stem Cells Authors: Nicolas Sirvent, Martine Trassard, Nathalie Ebran, Rita Attias, Florence Pedeutour Tags: Original articles Source Type: journals

Gene Dosage, Expression, and Ontology Analysis Identifies Driver Genes in the Carcinogenesis and Chemoradioresistance of Cervical CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author Summary Genetic gains and losses, i.e. changes in gene dosages, are common abnormalities of human cancers. Discovering these defects and understanding the biological meaning can lead to improved therapeutic opportunities. This paper reports a large scale screening of gene dosage alterations in cervical cancer and gives a broader exploration of the expression and function of genes with gains or losses. We have focused on the most frequent gene dosage alterations and the alterations associated with survival after chemoradiotherapy, since these defects are likely to be of major importance for developing disease. The m...
Source: PLoS Genetics - November 13, 2009 Category: Genetics & Stem Cells Authors: Malin Lando et al. Source Type: journals

Mutation prediction models in Lynch syndrome: evaluation in a clinical genetic settingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The Edinburgh and Premm1,2 model were the models with the best performance for an intermediate to high risk setting. These models may well be of use in clinical practice to select patients for further testing of mismatch repair gene mutations. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - October 30, 2009 Category: Genetics & Stem Cells Authors: Ramsoekh, D, van Leerdam, M E, Wagner, A, Kuipers, E J, Steyerberg, E W Tags: Molecular genetics, Colon cancer Original articles Source Type: journals

Phenotype and genotype in 17 patients with Goltz-Gorlin syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PORCN mutations can be found in all classically affected cases of Goltz–Gorlin syndrome, including males. Somatic and germline mosaicism occur. There is no evident genotype–phenotype correlation. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - October 1, 2009 Category: Genetics & Stem Cells Authors: Maas, S M, Lombardi, M P, van Essen, A J, Wakeling, E L, Castle, B, Temple, I K, Kumar, V K A, Writzl, K, Hennekam, R. C M Tags: Urological cancer, Dermatology, Calcium and bone Mutation report Source Type: journals

Baculovirus-Mediated Bispecific Short-Hairpin Small-Interfering RNAs Have Remarkable Ability to Cope With Both Influenza Viruses A and BEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oligonucleotides , Vol. 0, No. 0. (Source: Oligonucleotides)
Source: Oligonucleotides - November 9, 2009 Category: Genetics & Stem Cells Tags: article Source Type: journals

Interview: Acute myeloid leukemia patient genome interviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Personalized Medicine , November 2009, Vol. 6, No. 6, Pages 621-622. (Source: Future Medicine: Personalized Medicine)
Source: Future Medicine: Personalized Medicine - November 5, 2009 Category: Genetics & Stem Cells Tags: article Source Type: journals

Characterisation of psoriasis susceptibility locus 6 (PSORS6) in patients with early onset psoriasis and evidence for interaction with PSORS1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The data establish PSORS6 as a confirmed psoriasis susceptibility locus showing interaction with PSORS1. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - October 30, 2009 Category: Genetics & Stem Cells Authors: Huffmeier, U, Lascorz, J, Becker, T, Schurmeier-Horst, F, Magener, A, Ekici, A B, Endele, S, Thiel, C T, Thoma-Uszynski, S, Mossner, R, Reich, K, Kurrat, W, Wienker, T F, Traupe, H, Reis, A Tags: Genetic screening / counselling, Molecular genetics, Immunology (including allergy), Dermatology Original articles Source Type: journals

Novel SYT–SSX fusion transcript variants in synovial sarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Synovial sarcoma (SS) is characterized by the t(X;18)(p11.2;q11.2) chromosomal translocation detected in >95% of cases. Through this translocation, one of the SYT genes, SYT4 on chromosome 18, is fused to one of the SSX genes on chromosome X. SYT4–SSX1 is the most common fusion subtype, present in approximately two thirds of the cases, followed by SYT4–SSX2 and, very rarely, SYT4–SSX4. Variant fusion transcripts occur less often, and most of the reported cases are the result of small insertions. Described here is a novel fusion variant containing a small deletion resulting in an alternative reading frame of...
Source: Cancer Genetics and Cytogenetics - October 19, 2009 Category: Genetics & Stem Cells Authors: Euthimios Dimitriadis, Demetra Rontogianni, Anastasios Kyriazoglou, Anna Takou, Kostantina Frangia, Nikolaos Pandis, Theoni Trangas Tags: Original articles Source Type: journals

Detailed cytogenetic and array analysis of pediatric primitive sarcomas reveals a recurrent CIC–DUX4 fusion gene eventEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Pediatric undifferentiated soft tissue sarcomas (USTS) are a diagnostically challenging group of neoplasms. Recently, a subcategory of USTS with primitive round cell morphology and a t(4;19)(q35;q13) rearrangement has been defined. The present study applied high-throughput array comparative genomic hybridization together with spectral karyotyping, four-color fluorescence in situ hybridization (FISH), and reverse transcriptase–polymerase chain reaction (RT-PCR) to a series of three pediatric USTS. Two of these had primitive round cell morphology with CD99 positivity; the third had a spindled and myxoid appearanc...
Source: Cancer Genetics and Cytogenetics - October 19, 2009 Category: Genetics & Stem Cells Authors: Maisa Yoshimoto, Cassandra Graham, Susan Chilton-MacNeill, Eric Lee, Mary Shago, Jeremy Squire, Maria Zielenska, Gino R. Somers Tags: Original articles Source Type: journals

Monday, April 19, 2010 -- Lexinome, Proteome, Ima*Genome? New Views of DyslexiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Departments of Pediatrics, Genetics and Investigative Medicine Yale Child Health Research Center Yale University School of Medicine Part of the 2009-2010 NIH Neuroscience Seminar Series Host: Ellen Sidransky, M.D. (Source: NHGRI Events)
Source: NHGRI Events - November 2, 2009 Category: Genetics & Stem Cells Source Type: events