Genetics 
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This page shows you the most recent publications within this specialty of the MedWorm directory.
188476 records returned
A Teething Problem: Artefactual X-Ray Appearances of Odontoid Fracture due to Superimposed Incisor
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We report a case of artefactual C2 fracture caused by a superimposed incisor tooth in a seven-year-old boy. CT refuted the diagnosis. Trauma clinicians should be aware of this entity to guide correct interpretation of trauma X-rays. (Source: Comparative and Functional Genomics)
Source: Comparative and Functional Genomics - February 6, 2012 Category: Genetics & Stem Cells Source Type: research
Nonoscillatory Solutions of Second-Order Superlinear Dynamic Equations with Integrable CoefficientsEmail this article to a colleague.
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The asymptotic behavior of nonoscillatory solutions of the
superlinear dynamic equation on time scales (r(t)xΔ(t))Δ+p(t)|x(σ(t))|γsgnx(σ(t))=0, γ>1, is discussed under the condition that P(t)=limτ→∞∫tτp(s)Δs exists
and P(t)≥0 for large t. (Source: Comparative and Functional Genomics)
Source: Comparative and Functional Genomics - February 6, 2012 Category: Genetics & Stem Cells Source Type: research
On q-Gevrey Asymptotics for Singularly Perturbed q-Difference-Differential Problems with an Irregular SingularityEmail this article to a colleague.
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We study a q-analog of a singularly perturbed Cauchy problem with irregular singularity
in the complex domain which generalizes a previous result by Malek in (2011). First, we construct solutions defined in open q-spirals to the origin. By means of a q-Gevrey version of Malgrange-Sibuya theorem we show the existence of a formal power series in the perturbation parameter which turns out to be the q-Gevrey asymptotic expansion (of certain type) of the actual solutions. (Source: Comparative and Functional Genomics)
Source: Comparative and Functional Genomics - February 6, 2012 Category: Genetics & Stem Cells Source Type: research
Serum IL-18 Is Closely Associated with Renal Tubulointerstitial Injury and Predicts Renal Prognosis in IgA NephropathyEmail this article to a colleague.
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Background. IgA nephropathy (IgAN) was thought to be benign but recently found it slowly progresses and leads to ESRD eventually. The aim of this research is to investigate the value of serum IL-18 level, a sensitive biomarker for proximal tubule injury, for assessing the histopathological severity and disease progression in IgAN.
Methods. Serum IL-18 levels in 76 IgAN patients and 36 healthy blood donors were measured by ELISA. We evaluated percentage of global and segmental sclerosis (GSS) and extent of tubulointerstitial damage (TID). The correlations between serum IL-18 levels with clinical, histopathological features ...
Source: Comparative and Functional Genomics - February 6, 2012 Category: Genetics & Stem Cells Source Type: research
An Explicit Criterion for the Existence of Positive Solutions of the Linear Delayed Equation x˙(t)=−c(t)x(t−τ(t))Email this article to a colleague.
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The paper investigates an equation with single delay ẋ(t)=-c(t)x(t-τ(t)), where τ:[t0-r,∞)→(0,r], r>0, t0∈R, and c:[t0-r,∞)→(0,∞) are continuous functions, and the difference t-τ(t) is an increasing function. Its purpose is to derive a new explicit integral criterion for the existence of a positive solution in terms of c and τ. An overview of known relevant criteria is provided, and relevant comparisons are also given. (Source: Comparative and Functional Genomics)
Source: Comparative and Functional Genomics - February 6, 2012 Category: Genetics & Stem Cells Source Type: research
Small Interference RNA Targeting TLR4 Gene Effectively Attenuates Pulmonary Inflammation in a Rat ModelEmail this article to a colleague.
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Conclusion. TLR4 plays a critical role in LPS-induced ALI, and transfection of Ad-siTLR4 can effectively downregulate TLR4 expression in vitro and in vivo, accompanied by alleviation of LPS-induced lung injury. These findings suggest that TLR4 may serve as a potential target in the treatment of ALI and RNA interfering targeting TLR4 expression represents a therapeutic strategy. (Source: Comparative and Functional Genomics)
Source: Comparative and Functional Genomics - February 6, 2012 Category: Genetics & Stem Cells Source Type: research
Sympathetic Blocks Provided Sustained Pain Relief in a Patient with Refractory Painful Diabetic NeuropathyEmail this article to a colleague.
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The sympathetic nervous system has been implicated in pain associated with painful diabetic neuropathy. However, therapeutic intervention targeted at the sympathetic nervous system has not been established. We thus tested the hypothesis that sympathetic nerve blocks significantly reduce pain in a patient with painful diabetic neuropathy who has failed multiple pharmacological treatments. The diagnosis of small fiber sensory neuropathy was based on clinical presentations and confirmed by skin biopsies. A series of 9 lumbar sympathetic blocks over a 26-month period provided sustained pain relief in his legs. Additional thora...
Source: Comparative and Functional Genomics - February 6, 2012 Category: Genetics & Stem Cells Source Type: research
Variations of the Game 3-EuclidEmail this article to a colleague.
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We present two variations of the game 3-Euclid. The games involve a triplet of positive integers. Two players move alternately. In the first game, each move is to subtract a positive integer multiple of the smallest integer from one of the other integers as long as the result remains positive. In the second game, each move is to subtract a positive integer multiple of the smallest integer from the largest integer as long as the result remains positive. The player who makes the last move wins. We show that the two games have the same P-positions and positions of Sprague-Grundy value 1. We present three theorems on the perio...
Source: Comparative and Functional Genomics - February 6, 2012 Category: Genetics & Stem Cells Source Type: research
The Impact of Blue Inorganic Pigments on the Microwave Electrical Properties of Polymer CompositesEmail this article to a colleague.
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We present the results of the measurement of complex dielectric permittivity, in the microwave frequency region, on glass reinforced polybutylene terephthalate (PBT) with blue inorganic pigments. The cavity resonant method had been used in order to measure the shift in the resonant frequency of the cavity, caused by the insertion of a sample, which can be related to the real part of the complex permittivity. Also, the quality factor of the cavity decreases with the insertion of a sample. The changes in the inverse of this quality factor give the imaginary part. In order to predict the dielectric behavior of this composite,...
Source: Comparative and Functional Genomics - February 6, 2012 Category: Genetics & Stem Cells Source Type: research
Astrobiological Field Campaign to a Volcanosedimentary Mars Analogue Methane Producing Subsurface Protected Ecosystem: Imuruk Lake (Alaska)Email this article to a colleague.
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Viking missions reported adverse conditions for life in Mars surface. High hydrogen signal obtained by Mars orbiters has increased the interest in subsurface prospection as putative protected Mars environment with life potential. Permafrost has attracted considerable interest from an astrobiological point of view due to the recently reported results from the Mars exploration rovers. Considerable studies have been developed on extreme ecosystems and permafrost in particular, to evaluate the possibility of life on Mars and to test specific automated life detection instruments for space missions. The biodiversity of permafros...
Source: Comparative and Functional Genomics - February 6, 2012 Category: Genetics & Stem Cells Source Type: research
Mathematical Model of Hot Metal Desulfurization by Powder InjectionEmail this article to a colleague.
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Although there have been a numerous number of studies on mathematical model of hot metal desulfurization by deep injection of calcium carbide, the research field as a whole is not well integrated. This paper presents a model that takes into account the kinetics, thermodynamics, and transport processes to predict the sulfur levels in the hot metal throughout a blow. The model could be utilized to assess the influence of the treatment temperature, rate of injection, gas flow rate, and initial concentration of sulfur on the desulfurization kinetics. In the second part of this paper an analysis of the industrial data for injec...
Source: Comparative and Functional Genomics - February 6, 2012 Category: Genetics & Stem Cells Source Type: research
Gastroprotective Efficacy of Coenzyme Q10 in Indomethacin-Induced Gastropathy: Other Potential MechanismsEmail this article to a colleague.
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Tough recently the mitochondrial bioenergetic coenzyme (Co)Q10 has been shown to protect against indomethacin-induced gastric ulceration, yet the full mechanistic cassettes have not been investigated. Therefore, the current investigation assessed further gastroprotective mechanisms of CoQ10 using the indomethacin-induced gastropathy model. While CoQ10 was administered at 3 dose levels to male Wistar rats, the proton pump inhibitor, pantoprazole, was given at 4 dose levels ahead of pyloric ligation and indomethacin administration. Indomethacin evoked gastric ulcerations that were associated by decreased gastric mucosal nitr...
Source: Comparative and Functional Genomics - February 6, 2012 Category: Genetics & Stem Cells Source Type: research
Poor Homologous Synapsis 1 Interacts with Chromatin but Does Not Colocalise with ASYnapsis 1 during Early Meiosis in Bread WheatEmail this article to a colleague.
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Chromosome pairing, synapsis, and DNA recombination are three key processes that occur during early meiosis. A previous study of Poor Homologous Synapsis 1 (PHS1) in maize suggested that PHS1 has a role in coordinating these three processes. Here we report the isolation of wheat (Triticum aestivum) PHS1 (TaPHS1), and its expression profile during and after meiosis. While the TaPHS1 protein has sequence similarity to other plant PHS1/PHS1-like proteins, it also possesses a unique region of oligopeptide repeat units. We show that TaPHS1 interacts with both single- and double-stranded DNA in vitro and provide evidence of the ...
Source: Comparative and Functional Genomics - February 6, 2012 Category: Genetics & Stem Cells Source Type: research
Epidermolysis bullosa simplex with mottled pigmentation.Email this article to a colleague.
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We report a case of a young child with this rare disorder and explain the genetic cause.
PMID: 22301046 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - February 6, 2012 Category: Dermatology Authors: Browning JC, Mohr B Tags: Dermatol Online J Source Type: research
Cause Of Metabolic Disease Identified By Whole Exome SequencingEmail this article to a colleague.
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Sequencing a patient's entire genome to discover the source of his or her disease is not routine - yet. But geneticists are getting close. A case report, published this week in the American Journal of Human Genetics, shows how researchers can combine a simple blood test with an "executive summary" scan of the genome to diagnose a type of severe metabolic disease. Researchers at Emory University School of Medicine and Sanford-Burnham Medical Research Institute used "whole-exome sequencing" to find the mutations causing a glycosylation disorder in a boy born in 2004... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 6, 2012 Category: Consumer Health News Tags: Genetics Source Type: news
Controlling Gene Expression With New RNA-Based Therapeutic StrategiesEmail this article to a colleague.
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Small RNA-based nucleic acid drugs represent a promising new class of therapeutic agents for silencing abnormal or overactive disease-causing genes, and researchers have discovered new mechanisms by which RNA drugs can control gene activity. A comprehensive review article in Nucleic Acid Therapeutics, a peer-reviewed journal published by Mary Ann Liebert, Inc., details these advances. Short strands of nucleic acids, called small RNAs, can be used for targeted gene silencing, making them attractive drug candidates... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 6, 2012 Category: Consumer Health News Tags: Genetics Source Type: news
Gene Related To Fat Preferences In Humans FoundEmail this article to a colleague.
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A preference for fatty foods has a genetic basis, according to researchers, who discovered that people with certain forms of the CD36 gene may like high-fat foods more than those who have other forms of this gene. The results help explain why some people struggle when placed on a low-fat diet and may one day assist people in selecting diets that are easier for them to follow. The results also may help food developers create new low-fat foods that taste better. "Fat is universally palatable to humans," said Kathleen Keller, assistant professor of nutritional sciences, Penn State... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 6, 2012 Category: Consumer Health News Tags: Nutrition / Diet Source Type: news
Medicago truncatula transporter database: a comprehensive database resource for M. truncatula transportersEmail this article to a colleague.
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Conclusions:
In summary, the MTDB enables the exploration and comparative analysis of putative transporters in M. truncatula. A user-friendly web interface and regular updates make MTDB valuable to researchers in related fields. The MTDB is freely available now to all users at http://bioinformatics.cau.edu.cn/MtTransporter/. (Source: BMC Genomics - Latest articles)
Source: BMC Genomics - Latest articles - February 6, 2012 Category: Genetics & Stem Cells Authors: Zhenyan MiaoDaofeng LiZhenhai ZhangJiangli DongZhen SuTao Wang Source Type: research
Ac/Ds-transposon activation tagging in poplar: a powerful tool for gene discoveryEmail this article to a colleague.
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Conclusions:
The novel strategy of first genotyping and then phenotyping a tagging population as proposed here is, in particular, applicable for long-lived, difficult to transform plant species. We could demonstrate the power of the ATDs transposon approach and the simplicity to induce ATDs transposition in vitro. Since a transposon is able to pass chromosomal boundaries, only very few primary transposon-carrying transgenic lines are required for the establishment of large transposon tagging populations. In contrast to T-DNA-based activation tagging, which is plagued by a lack of transformation efficiency and its time cons...
Source: BMC Genomics - Latest articles - February 6, 2012 Category: Genetics & Stem Cells Authors: Matthias FladungOlaf Polak Source Type: research
New virtual tool may provide more accurate diagnosis of genetic mutationsEmail this article to a colleague.
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(Elsevier Health Sciences) DNA sequencing to detect genetic mutations can aid in the diagnosis and selection of treatment for cancer. Current methods of testing DNA samples, Sanger sequencing and pyrosequencing, occasionally produce complex results that can be difficult or impossible to interpret. Scientists at the Johns Hopkins University School of Medicine have developed a free software program, Pyromaker, that can more accurately identify such complex genetic mutations. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 6, 2012 Category: Global & Universal Source Type: news
Personalized therapy of lung cancer.Email this article to a colleague.
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Abstract
The implementation of personalized approaches in the treatment of patients with non-small cell lung cancer (NSCLC) requires a precise understanding of tumor biology, a reorientation of clinical development with a strong focus on genetically stratified early phase 'proof of concept' trials, the availability of high-quality 'realtime' genetic diagnostics, and the establishment of networks for molecular screening of lung cancer patients. To achieve this goal, a close interaction between basic researchers, clinical scientists, molecular pathologists, and pharmaceutical companies is essential. We believe that t...
Source: Onkologie - February 5, 2012 Category: Cancer & Oncology Authors: Thomas R, Wolf J Tags: Onkologie Source Type: research
Targeted therapy of soft tissue sarcomas.Email this article to a colleague.
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Abstract
Soft tissue sarcomas (STS) are rare mesenchymal cancers with a heterogeneous histology. In terms of oncogenesis, sarcomas may be differentiated into diseases with defined molecular events and sarcomas presenting with complex karyotypes lacking identifiable specific genetic changes or expression profile signatures. The former subtype is amenable to therapy with targeted drugs, especially if the tumor carries a consistent causal mutation occurring early in the disease development. While targeted therapy based on tyrosine kinase inhibition such as imatinib and second generation tyrosine kinase inhibitors play...
Source: Onkologie - February 5, 2012 Category: Cancer & Oncology Authors: Wardelmann E, Chemnitz JM, Wendtner CM Tags: Onkologie Source Type: research
Personalized therapy in breast cancer.Email this article to a colleague.
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Abstract
Systemic treatment of non-metastatic breast cancer is based on endocrine therapy, cytotoxic chemotherapy, and molecular targeted therapy - with the major problems of immense overtreatment of patients who would not relapse without systemic therapy and the failure of treatment in others whose disease still recurs. These deficits can only be overcome by the identification of new and better prognostic and predictive markers. Currently, adjuvant treatment stratification is based on a limited number of established factors, namely locoregional tumour stage, age, grade, expression of hormone receptors, HER2, and K...
Source: Onkologie - February 5, 2012 Category: Cancer & Oncology Authors: Marmé F, Schneeweiss A Tags: Onkologie Source Type: research
Mutant gene clue to beat strokesEmail this article to a colleague.
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THOUSANDS of lives could be saved after the discovery of a genetic mutation which dramatically increases the risk of strokes. (Source: Daily Express - Health)
Source: Daily Express - Health - February 5, 2012 Category: Consumer Health News Source Type: news
What Are the Major Diseases Involving Copper Metabolism?Email this article to a colleague.
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Discussion
Nutritional problems can occur in all parts of the world and in all socioeconomic strata. Caloric and/or protein inadequacy unfortunately plagues too many people because of inadequate supplies or availability. Supplemental food programs around the world attempt to provide appropriate nutrition, but can be stymied because of war, political instability, economic instability and many other social factors.
The most common specific nutrient deficiencies are iron and Vitamin D deficiencies. Minerals important for essential nutrition include copper, iodine, selenium and zinc. A typical mixed diet usually provides enou...
Source: PediatricEducation.org - February 5, 2012 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news
Immunology in clinic review series; focus on autoinflammatory diseases: update on monogenic autoinflammatory diseases: the role of interleukin (IL)-1 and an emerging role for cytokines beyond IL-1.Email this article to a colleague.
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Abstract
OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases. SUMMARY: The disease-based discovery of the molecular basis for autoinflammatory diseases has led not only to a rapidly growing number of clinically and genetically identifiable disorders, but has unmantled key inflammatory pathways such as the potent role of the alarm cytokine interleukin (IL)-1 in human disease. Following its initial failures in the treatment of sepsis and the moderate success in the treatment of rheumatoid arthritis, IL-1 blocking therap...
Source: Clinical and Developmental Immunology - February 5, 2012 Category: Allergy & Immunology Authors: Goldbach-Mansky R Tags: Clin Exp Immunol Source Type: research
Complete deficiency of the sixth complement component (C6Q0), susceptibility to Neisseria meningitidis infections and analysis of the frequencies of C6Q0 gene defects in South Africans.Email this article to a colleague.
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Abstract
Complete complement component 6 deficiency (C6Q0) is a co-dominant genetic disease presenting as increased susceptibility to invasive Neisseria meningitidis infections. Affected individuals have two affected alleles which can be homozygous or compound heterozygous for the particular gene defects they carry. This disorder has been diagnosed relatively frequently in Western Cape South Africans. Affected patients are prescribed penicillin prophylaxis. In 2004 we commenced a clinical follow-up study of 46 patients. Of these, 43 had family age-matched C6 sufficient controls. Participants were classified as eith...
Source: Clinical and Developmental Immunology - February 5, 2012 Category: Allergy & Immunology Authors: Orren A, Owen EP, Henderson HE, van der Merwe L, Leisegang F, Stassen C, Potter PC Tags: Clin Exp Immunol Source Type: research
The European internet-based patient and research database for primary immunodeficiencies: update 2011.Email this article to a colleague.
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Abstract
In order to build a common data pool and estimate the disease burden of primary immunodeficiencies (PID) in Europe, the European Society for Immunodeficiencies (ESID) has developed an internet-based database for clinical and research data on patients with PID. This database is a platform for epidemiological analyses as well as the development of new diagnostic and therapeutic strategies and the identification of novel disease-associated genes. Since its start in 2004, 13 708 patients from 41 countries have been documented in the ESID database. Common variable immunodeficiency (CVID) represents the most ...
Source: Clinical and Developmental Immunology - February 5, 2012 Category: Allergy & Immunology Authors: Gathmann B, Binder N, Ehl S, Kindle G, Tags: Clin Exp Immunol Source Type: research
Best Treatment For TB Patients Could Be Determined By 'Goldilocks' GeneEmail this article to a colleague.
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'Tuberculosis patients may receive treatments in the future according to what version they have of a single 'Goldilocks' gene, says an international research team from Oxford University, King's College London, Vietnam and the USA. This is one of the first examples in infectious disease of where an individual's genetic profile can determine which drug will work best for them - the idea of personalised medicine that is gradually becoming familiar in cancer medicine... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 5, 2012 Category: Consumer Health News Tags: Tuberculosis Source Type: news
The fibroblast growth factor signaling axis controls cardiac stem cell differentiation through regulating autophagy.Email this article to a colleague.
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Abstract
The fibroblast growth factor (FGF) signaling axis plays important roles in heart development. Yet, the molecular mechanism by which the FGF regulates cardiogenesis is not fully understood. Using genetically engineered mouse and in vitro cultured embryoid body (EB) models, we demonstrate that FGF signaling suppresses premature differentiation of heart progenitor cells, as well as autophagy in outflow tract (OFT) myocardiac cells. The FGF also promotes mesoderm differentiation in embryonic stem cells (ESCs) but inhibits cardiomyocyte differentiation of the mesoderm cells at later stages. Furthermore, inhibit...
Source: Autophagy - February 5, 2012 Category: Cytology Authors: Zhang J, Liu J, Liu L, McKeehan WL, Wang F Tags: Autophagy Source Type: research
Brassinosteroid regulates stomatal development by GSK3-mediated inhibition of a MAPK pathwayEmail this article to a colleague.
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-Yong Wang
Plants must coordinate the regulation of biochemistry and anatomy to optimize photosynthesis and water-use efficiency. The formation of stomata, epidermal pores that facilitate gas exchange, is highly coordinated with other aspects of photosynthetic development. The signalling pathways controlling stomata development are not fully understood, although mitogen-activated protein kinase (MAPK) signalling is known to have key roles. Here we demonstrate in Arabidopsis that brassinosteroid regulates stomatal development by activating the MAPK kinase kinase (MAPKKK) YDA (also known as YODA). Genetic analyses indicate t...
Source: Nature AOP - February 5, 2012 Category: Research Authors: Tae-Wuk KimMarta MichniewiczDominique C. BergmannZhi-Yong Wang Tags: Letter Source Type: research
DNase I sensitivity QTLs are a major determinant of human expression variationEmail this article to a colleague.
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DNase I sensitivity QTLs are a major determinant of human expression variation
Nature advance online publication 05 February 2012. doi:10.1038/nature10808
Authors: Jacob F. Degner, Athma A. Pai, Roger Pique-Regi, Jean-Baptiste Veyrieras, Daniel J. Gaffney, Joseph K. Pickrell, Sherryl De Leon, Katelyn Michelini, Noah Lewellen, Gregory E. Crawford, Matthew Stephens, Yoav Gilad & Jonathan K. Pritchard
The mapping of expression quantitative trait loci (eQTLs) has emerged as an important tool for linking genetic variation to changes in gene regulation. However, it remains difficult to identify the causal variants un...
Source: Nature AOP - February 5, 2012 Category: Research Authors: Jacob F. DegnerAthma A. PaiRoger Pique-RegiJean-Baptiste VeyrierasDaniel J. GaffneyJoseph K. PickrellSherryl De LeonKatelyn MicheliniNoah LewellenGregory E. CrawfordMatthew StephensYoav GiladJonathan K. Pritchard Tags: Letter Source Type: research
Genetic variant increases risk of common type strokeEmail this article to a colleague.
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(Wellcome Trust) A genetic variant that increases the risk of a common type of stroke has been identified by scientists in a study published online in Nature Genetics today. This is one of the few genetic variants to date to be associated with risk of stroke and the discovery opens up new possibilities for treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 5, 2012 Category: Global & Universal Source Type: news
The association between two polymorphisms in the TS gene and risk of cancer: A systematic review and pooled analysisEmail this article to a colleague.
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AbstractThymidylate synthase (TS) is an important enzyme involved in folate metabolism and catalyzes methylation of dUMP to dTMP, which is essential for DNA replication. TSER and TS1494del6, two functionally important and ethnically diverse polymorphisms mapping to its gene region, are the most extensively studied. Considering the potential influence of altering TS activity, it is plausible that TS polymorphisms might play a role in the development of cancer. Although the effects of TS polymorphisms on susceptibility to human cancer have been investigated in many studies, the results remain conflicting rather than conclusi...
Source: International Journal of Cancer - February 5, 2012 Category: Cancer & Oncology Authors: Jue‐Yu ZhouRong ShiHai‐Lang YuYe ZengWen‐Ling ZhengWen‐Li Ma Tags: Epidemiology Source Type: research
Dynamic Genetics and the SGDP spACE Program (2012-02-08)Email this article to a colleague.
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Recent large-scale genome-wide association studies have been successful in identifying some of the genetic variants associated with complex human disorders. We often assume these associations will hold true within the same population irrespective of age or environmental context. However, twin and family studies tell us that for some traits heritability increases throughout childhood and adolescen (Source: Institute of Psychiatry | Events)
Source: Institute of Psychiatry | Events - February 4, 2012 Category: Psychiatry Tags: seminar Source Type: news
Genetic Connection To Traumatic ExperienceEmail this article to a colleague.
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Rutgers scientists have uncovered genetic clues as to why some mice no longer in danger are still fearful while others are resilient to traumatic experiences - knowledge that could help those suffering with crippling anxiety and PTSD. "Our work with mice demonstrates how genes play a role in developing and extinguishing pathological fear like Post Traumatic Stress Disorder," says Gleb Shumyatsky, an associate professor in the Department of Genetics in the School of Arts and Sciences... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 4, 2012 Category: Consumer Health News Tags: Psychology / Psychiatry Source Type: news
[Seminar] Non-specific low back painEmail this article to a colleague.
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Non-specific low back pain has become a major public health problem worldwide. The lifetime prevalence of low back pain is reported to be as high as 84%, and the prevalence of chronic low back pain is about 23%, with 11–12% of the population being disabled by low back pain. Mechanical factors, such as lifting and carrying, probably do not have a major pathogenic role, but genetic constitution is important. History taking and clinical examination are included in most diagnostic guidelines, but the use of clinical imaging for diagnosis should be restricted. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Federico Balagué, Anne F Mannion, Ferran Pellisé, Christine Cedraschi Tags: Seminar Source Type: research
What Are the Causes of Bipolar Disorder?Email this article to a colleague.
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In Part 2 of Bipolar for Beginners, we take a look at what scientists believe are the causes - genetic, physical and psychological - of bipolar disorder. For whatever reason you want to know more about this illness, here is information in clear English that will answer some of your questions about things like whether bipolar is inherited, the part brain chemistry plays in bipolar, and how researchers believe it all fits together. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - February 4, 2012 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news
Variation at GLCCI1 and FCER2: one step closer to personalized asthma treatmentEmail this article to a colleague.
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Pharmacogenomics , February 2012, Vol. 13, No. 3, Pages 243-245. (Source: Future Medicine: Pharmacogenomics)
Source: Future Medicine: Pharmacogenomics - February 3, 2012 Category: Genetics & Stem Cells Tags: article Source Type: research
Genetic Variation inMMP20Contributes to Higher Caries ExperienceEmail this article to a colleague.
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ConclusionVariation inMMP20may be associated with caries experience mainly in Caucasian subjects with poor oral health habits (Source: Journal of Dentistry)
Source: Journal of Dentistry - February 3, 2012 Category: Dentistry Source Type: research
Response Genetics raises $7.8 million in stock saleEmail this article to a colleague.
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Response Genetics Inc. said it has raised more than $7.8 million through the private placement of 5.3 million in newly issued stock.
The Los Angeles-based company, which makes molecular diagnostic tests for cancer, said it sold the shares to undisclosed investors for $1.50 a share, a premium of 27 percent above its closing stock price of $1.18 a share on Wednesday.
New investors accounted for the majority of the financing, while existing investors, as well as board members and senior management, made up the remainder, Response Genetics said... (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - February 3, 2012 Category: Biotechnology Source Type: research
Response Genetics raises $7.8 million in stock saleEmail this article to a colleague.
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Response Genetics Inc. said it has raised more than $7.8 million through the private placement of 5.3 million in newly issued stock.
The Los Angeles-based company, which makes molecular diagnostic tests for cancer, said it sold the shares to undisclosed investors for $1.50 a share, a premium of 27 percent above its closing stock price of $1.18 a share on Wednesday.
New investors accounted for the majority of the financing, while existing investors, as well as board members and senior management, made up the remainder, Response Genetics said... (Source: bizjournals.com Health Care:Hospitals headlines)
Source: bizjournals.com Health Care:Hospitals headlines - February 3, 2012 Category: Hospital Management Source Type: research
Wide-range protein photo-crosslinking achieved by a genetically encoded N[varepsilon]-(benzyloxycarbonyl)lysine derivative with a diazirinyl moietyEmail this article to a colleague.
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Mol. BioSyst., 2012, Advance ArticleDOI: 10.1039/C2MB05321G, CommunicationTatsuo Yanagisawa, Nobumasa Hino, Fumie Iraha, Takahito Mukai, Kensaku Sakamoto, Shigeyuki YokoyamaA method for wide-range in vivo protein photo-crosslinking has been developed by the site-specific incorporation of a large, photo-crosslinkable, non-natural amino acid into proteins.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - February 3, 2012 Category: Molecular Biology Authors: Tatsuo Yanagisawa Source Type: research
Lab Notes: Wall Street Success GeneticEmail this article to a colleague.
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(MedPage Today) -- A look at why some stockbrokers are successful, a study that brings oncologists' worst nightmare to life, and a timely Eureka moment in the war against parasites highlight this week's collection of Lab Notes. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - February 3, 2012 Category: Cardiology Source Type: news
White House Begins to Map Course toward Bio-Based EconomyEmail this article to a colleague.
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Politicians and pundits clogged the airwaves last year with rhetoric about the state of the nation's economy. Amid this noise, a few economic policy initiatives did begin to take shape. For instance, last fall, the White House Office of Science and Technology Policy (OSTP) issued a request for comments on a draft policy to stimulate the bioeconomy.
Scientists have long asserted that research is an investment that yields economic prosperity. A growing number of scientists and engineers have more recently advised that the biological sciences are poised to inspire transformative discoveries that can solve persistent problems...
Source: Washington Watch - February 3, 2012 Category: Biology Authors: Robert E. Gropp Source Type: news
Hepatitis Research May Benefit From Stem CellsEmail this article to a colleague.
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Hepatitis C is a viral disease that leads to inflammation and organ failure. However, researchers are puzzled as to why some individuals are very susceptible to the disease, while others are not. Researchers believe they could find out how genetic variations produce these different responses by investigating liver cells from different individuals in the lab. However, liver cells are hard to obtain and extremely challenging to grow in a lab dish as they often lose their normal function and structure when removed from the body... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 3, 2012 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news
Genetics: Wrapped Up RightEmail this article to a colleague.
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All eukaryotic chromosomes have a centromere, which ensures that the genomic DNA is shared equally between daughter cells during cell division. Centromeres are defined by the presence of nucleosomes that … [Read more] (Source: Editors' Choice)
Source: Editors' Choice - February 3, 2012 Category: Science Authors: Stewart Wills (mailto:swills at aaas.org) Source Type: research
[News of the Week] NewsmakersEmail this article to a colleague.
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This week's Newsmakers are Janet Rowley of the University of Chicago, Brian Druker of the Oregon Health & Science University, Nicholas Lydon of Blueprint Medicines, and Masato Sagawa of Intermetallics Co., winners of the Japan Prizes; Scott Doney, whose nomination to be chief scientist of the National Oceanic and Atmospheric Administration has been withdrawn by the White House; Johannes Vogel, an expert on fern genetics, who took over as director of Berlin's Natural History Museum this week; and Paul Alivisatos of Lawrence Berkeley National Laboratory, Charles Lieber of Harvard University, Jacob Bekenstein of the Hebrew Un...
Source: Science: Current Issue - February 3, 2012 Category: Science Authors: Stewart Wills (mailto:swills at aaas.org) Source Type: research
Editors' ChoiceEmail this article to a colleague.
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Astronomy: A Comet Dates Jupiter | Sociology: I Liked You From the Start | Genetics: Wrapped Up Right | Climate Science: Here's Looking at You | Cell Biology: Push Me Pull You | Chemistry: Sacrifices at the Surface | Education: Science Illustrated (Source: Science: Current Issue)
Source: Science: Current Issue - February 3, 2012 Category: Science Authors: Stewart Wills (mailto:swills at aaas.org) Source Type: research
