Genetics Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.
Find the best Christmas presents and January Sales in the UK with this simple shopping directory.
This page shows you the most recent publications within this specialty of the MedWorm directory.
Rapid multiplexed genotyping of simple tandem repeats using capture and high‐throughput sequencing
This article is protected by copyright. All rights reserved (Source: Human Mutation)
Source: Human Mutation - May 21, 2013 Category: Genetics & Stem Cells Authors: Audrey Guilmatre, Gareth Highnam, Christelle Borel, David Mittelman, Andrew J. Sharp Tags: Methods Source Type: research
This Month in AJKD
See Olden et al, pages 889-898; and Rao, pages 851-854. Cardiovascular disease (CVD) is the major complication of CKD, and most people with kidney disease die of CVD before kidney failure; however, the mechanisms of excess cardiovascular risk in CKD patients are not fully understood. In this month's AJKD, Olden et al test the hypothesis that genetic kidney variants might increase the risk of vascular disease and that these vascular variants might be associated with kidney disease traits. The authors report that while they confirmed one locus (SH2B3) as associated with both kidney and cardiovascular disease, the primary fi...
Source: American Journal of Kidney Diseases - May 20, 2013 Category: Urology & Nephrology Source Type: research
How was Angelina Jolie's breast cancer risk calculated?
Breast cancer geneticist Allison Kurian explains how lifetime risk for invasive cancer is determined and used to guide treatment (Source: New Scientist - Genetics)
Source: New Scientist - Genetics - May 20, 2013 Category: Genetics & Stem Cells Source Type: research
Human “Monogenic” Disease Gene Discovery: When Models of Inheritance Go Wrong
(Source: Human Mutation)
Source: Human Mutation - May 20, 2013 Category: Genetics & Stem Cells Authors: Hamish S. Scott Tags: In This Issue Source Type: research
New Tools of the Trade for Large‐scale Collaborative Genome Analysis
(Source: Human Mutation)
Source: Human Mutation - May 20, 2013 Category: Genetics & Stem Cells Authors: Madhuri Hegde Tags: In This Issue Source Type: research
Exome Resequencing Identifies Potential Tumor‐Suppressor Genes that Predispose to Colorectal Cancer
ABSTRACT Inherited factors account for around one third of all colorectal cancers (CRCs) and include rare high penetrance mutations in APC, MSH2, MSH6, and POLE. Here, we sought novel tumor‐suppressor genes that predispose to CRC by exome resequencing 50 sporadic patients with advanced CRC (18 diagnosed ≤35 years of age) at a mean coverage of 30×. To help identify potentially pathogenic alleles, we initially sought rare or novel germline truncating mutations in 1,138 genes that were likely to play a role in colorectal tumorigenesis. In total, 32 such mutations were identified and confirmed, and included an insertion i...
Source: Human Mutation - May 20, 2013 Category: Genetics & Stem Cells Authors: Christopher G. Smith, Marc Naven, Rebecca Harris, James Colley, Hannah West, Ning Li, Yuan Liu, Richard Adams, Timothy S. Maughan, Laura Nichols, Richard Kaplan, Michael J. Wagner, Howard L. McLeod, Jeremy P. Cheadle Tags: Research Article Source Type: research
HAPLOFIND: A New Method for High‐Throughput mtDNA Haplogroup Assignment
This article is protected by copyright. All rights reserved (Source: Human Mutation)
Source: Human Mutation - May 20, 2013 Category: Genetics & Stem Cells Authors: Dario Vianello, Federica Sevini, Gastone Castellani, Lomartire Laura, Miriam Capri, Claudio Franceschi Tags: Informatics Source Type: research
Pathogenic mitochondrial tRNA point mutations: nine novel mutations affirm their importance as a cause of mitochondrial disease
This article is protected by copyright. All rights reserved (Source: Human Mutation)
Source: Human Mutation - May 20, 2013 Category: Genetics & Stem Cells Authors: Emma L. Blakely, John W. Yarham, Charlotte L. Alston, Kate Craig, Joanna Poulton, Charlotte Brierley, Soo‐Mi Park, Andrew Dean, John H. Xuereb, Kirstie N. Anderson, Alistair Compston, Chris Allen, Saba Sharif, Peter Enevoldson, Martin Wilson, Simon R. H Tags: Research Article Source Type: research
Human alpha‐ and beta‐NRXN1 isoforms rescue behavioral impairments of Caenorhabditis elegans neurexin‐deficient mutants
Neurexins are cell adhesion proteins that interact with neuroligin and other ligands at the synapse. In humans, mutations in neurexin or neuroligin genes have been associated with autism and other mental disorders. The human neurexin and neuroligin genes are orthologous to the Caenorhabditis elegans genes nrx‐1 and nlg‐1, respectively. Here we show that nrx‐1‐deficient mutants are defective in exploratory capacity, sinusoidal postural movements and gentle touch response. Interestingly, the exploratory behavioral phenotype observed in nrx‐1 mutants was markedly different to nlg‐1‐deficient mutants; thus, while...
Source: Genes, Brain and Behavior - May 20, 2013 Category: Genetics & Stem Cells Authors: F. Calahorro, M. Ruiz‐Rubio Tags: Original Article Source Type: research
Characterization of 2 Genetic Variants of Nav1.5‐Arginine 689 Found in Patients with Cardiac Arrhythmias
In conclusion, despite the fact that the causality link between p.R689H and the phenotype of the studied family cannot be demonstrated, this study supports the notion that subtle alterations of Nav1.5 variants may increase the risk for cardiac arrhythmias. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - May 20, 2013 Category: Cardiology Authors: VALENTIN SOTTAS, JEAN‐SÉBASTIEN ROUGIER, FLORIAN JOUSSET, JAN P. KUCERA, ANNA SHESTAK, LEONID M. MAKAROV, ELENA V. ZAKLYAZMINSKAYA, HUGUES ABRIEL Tags: Original Article Source Type: research
Molecular ecology of the Neotropical otter (Lontra longicaudis): non‐invasive sampling yields insights into local population dynamics
Non‐invasive genetic analysis has been frequently employed to estimate ecological and population parameters for many secretive and/or threatened species. However, Neotropical carnivores have so far been scarcely targeted by such studies. The Neotropical otter (Lontra longicaudis) is a poorly‐known species for which local levels of genetic diversity and demographic parameters are virtually absent. We employed non‐invasive sampling and amplification of microsatellite loci to investigate population size and density, spatial organization, and relatedness of a wild Neotropical otter population in an Atlantic forest area i...
Source: Biological Journal of the Linnean Society - May 20, 2013 Category: Research Authors: Cristine Silveira Trinca, Camila Fernandes Jaeger, Eduardo Eizirik Tags: Research Article Source Type: research
PCR on yeast colonies: an improved method for glyco-engineered Saccharomyces cerevisiae
Conclusions: The developed protocol enables by-passing of many of the difficulties associated with PCR caused by phenotypic modifications brought about by humanisation of the glycosylation in yeast and allows rapid validation of glyco-engineered Saccharomyces cerevisiae cells. It has the potential to be extended to other yeast strains presenting cell wall structure modifications. (Source: BMC Research Notes)
Source: BMC Research Notes - May 20, 2013 Category: Research Authors: Christine BonnetCéline RigaudEmilie ChanteclaireClaire BlandaisEmilie Tassy-FrechesChristelle AricoChristophe Javaud Source Type: research
Reintroductions and genetic introgression from domestic pigs have shaped the genetic population structure of Northwest European wild boar
Conclusions: Our results demonstrate that wildlife and landscape management by humans are shaping the genetic diversity of an iconic wildlife species. Historical reintroductions, translocation and recent restocking activities with farmed wild boar have all influenced wild boar genetic population structure. The current trend of wild boar population growth and range expansion has recently led to a number of contact zones between clusters, and further admixture between the different wild boar clusters is to be expected. (Source: BMC Genetics - Latest articles)
Source: BMC Genetics - Latest articles - May 20, 2013 Category: Genetics & Stem Cells Authors: Daniel GoedbloedPim van HooftHendrik-Jan MegensKatharina LangenbeckWalburga LutzRichard CrooijmansSip van WierenRon YdenbergHerbert Prins Source Type: research
Risk interaction of obesity, insulin resistance and hormone-sensitive lipase promoter polymorphisms (LIPE-60 C > G) in the development of fatty liver
Conclusion: Adipo-IR, rather than HOMA-IR, appears to be a consistent insulin resistance index in the study of NAFLD. G allele of the HSL promoter polymorphism may contribute the greatest impact raising serum triglyceride in a state of glucose intolerance. (Source: BMC Medical Genetics - Latest articles)
Source: BMC Medical Genetics - Latest articles - May 20, 2013 Category: Genetics & Stem Cells Authors: Pi-Jung HsiaoZhih-Cherg ChenWei-Wen HungYi-Hsin YangMei-Yueh LeeJee-Fu HuangKung-Kai Kuo Source Type: research
Disease-modifying factors in hereditary angioedema: an RNA expression-based screening
Conclusion: We found no evidence for a common altered PBMC expression pattern linked to HAE symptoms in the three families analyzed. All the data considered, differential gene expression in PBMCs do not seem to play a significant role in the predisposition or protection against HAE in the basal -between crises- conditions analyzed. Although the RNA expression pattern associated to the response to viral infections observed in the DR family supports the idea of infectious diseases as a modifying factor for HAE severity, large-scale studies would be needed to statistically associate such expression pattern to the development ...
Source: Orphanet Journal of Rare Diseases - May 20, 2013 Category: Internal Medicine Authors: Alberto López-LeraFátima Sánchez CaboSofía GarridoAna DopazoMargarita López-Trascasa Source Type: research
The role of microRNAs in the pathogenesis of MMPi-induced skin fibrodysplasia
Conclusions: Our data reveal significant perturbations in canine skin miRNA expression in response to MMPi administration. Furthermore, we have identified dysregulated miRNAs that are associated with processes relevant to the key histopathological events of MMPi-induced FD. (Source: BMC Genomics - Latest articles)
Source: BMC Genomics - Latest articles - May 20, 2013 Category: Genetics & Stem Cells Authors: Daniel TongeJonathan TugwoodJanet KelsallTimothy Gant Source Type: research
Vitamin D nuclear receptor deficiency promotes cholestatic liver injury by disruption of biliary epithelial cell junctions in mice
Conclusion: Biliary‐type liver injury is exacerbated in Vdr‐/‐mice by limited adaptive response and increased bile duct rupture. These results indicate that loss of VDR restricts the adaptation to cholestasis and diminishes bile duct integrity in the setting of biliary‐type liver injury. (HEPATOLOGY2013.) (Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Delphine Firrincieli, Silvia Zúñiga, Colette Rey, Dominique Wendum, Elisabeth Lasnier, Dominique Rainteau, Thomas Braescu, Thomas Falguières, Mathieu Boissan, Axelle Cadoret, Chantal Housset, Nicolas Chignard Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research
Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis
Conclusions: Characterization of the gene cluster provides a blueprint for engineering new pneumocandin derivatives with improved pharmacological properties. Whole genome estimation of the secondary metabolite-encoding genes from G. lozoyensis provides yet another example of the huge potential for drug discovery from natural products from the fungal kingdom. (Source: BMC Genomics - Latest articles)
Source: BMC Genomics - Latest articles - May 20, 2013 Category: Genetics & Stem Cells Authors: Li ChenQun YueXinyu ZhangMeichun XiangChengshu WangShaojie LiYongsheng CheFrancisco Ortiz-LópezGerald BillsXingzhong LiuZhiqiang An Source Type: research
Multiple genetic pathways regulate replicative senescence in telomerase‐deficient yeast
This article is protected by copyright. All rights reserved. (Source: Aging Cell)
Source: Aging Cell - May 18, 2013 Category: Cytology Authors: Bari J. Ballew, Victoria Lundblad Tags: Original Article Source Type: research
Genetic analysis of sudden unexplained death: A multidisciplinary approach
This study demonstrates that molecular genetic screening needs to become an inherent part of the postmortem examination. This will enhance the ability of screening family members of SUD victims who may be at risk. The present data also illustrate that detection and follow up of familial cases of sudden death is challenging and requires a close multidisciplinary collaboration between different medical disciplines, with great responsibility for the forensic pathologist. (Source: Forensic Science International)
Source: Forensic Science International - May 17, 2013 Category: Forensic Medicine Authors: Silke Kauferstein, Nadine Kiehne, Tina Jenewein, Stephanie Biel, Marnie Kopp, Rainer König, Damir Erkapic, Markus Rothschild, Thomas Neumann Tags: Research Articles Source Type: research
Suicidal behaviour is a disease, psychiatrists argue
Evidence from brain and genetic studies suggests we should regard suicidal behaviour as a disease in its own right, a move that may help prevent suicides (Source: New Scientist - Health)
Source: New Scientist - Health - May 17, 2013 Category: Consumer Health News Source Type: research
PrePrint: Stochastic Model Simulation Using Kronecker Product Analysis and Zassenhaus Formula Approximation
Probabilistic Models are regularly applied in Genetic Regulatory Network modeling to capture the stochastic behavior observed in the generation of biological entities such as mRNAs or proteins. Several approaches including Stochastic Master Equation (SME) and Probabilistic Boolean Network (PBN) have been proposed to model the stochastic behavior in genetic regulatory networks. It is generally accepted that SME is a fundamental model that can describe the system being investigated in fine detail, but the application of this model is computationally enormously expensive. On the other hand, PBN captures only the coarse-scale ...
Source: IEEE/ACM Transactions on Computational Biology and Bioinformatics - May 17, 2013 Category: Bioinformatics Source Type: research
Wavelet adaptation for automatic voice disorders sorting
Abstract: Early diagnosis of voice disorders and abnormalities by means of digital speech processing is a subject of interest for many researchers. Various methods are introduced in the literature, some of which are able to extensively discriminate pathological voices from normal ones. Voice disorders sorting, on the other hand, has received less attention due to the complexity of the problem. Although, previous publications show satisfactory results in classifying one type of disordered voice from normal cases, or two different types of abnormalities from each other, no comprehensive approach for automatic sorting of voca...
Source: Computers in Biology and Medicine - May 17, 2013 Category: Bioinformatics Authors: Nafise Erfanian Saeedi, Farshad Almasganj Source Type: research
An ensemble of SVM classifiers based on gene pairs
Abstract: In this paper, a genetic algorithm (GA) based ensemble support vector machine (SVM) classifier built on gene pairs (GA-ESP) is proposed. The SVMs (base classifiers of the ensemble system) are trained on different informative gene pairs. These gene pairs are selected by the top scoring pair (TSP) criterion. Each of these pairs projects the original microarray expression onto a 2-D space. Extensive permutation of gene pairs may reveal more useful information and potentially lead to an ensemble classifier with satisfactory accuracy and interpretability. GA is further applied to select an optimized combination of bas...
Source: Computers in Biology and Medicine - May 17, 2013 Category: Bioinformatics Authors: Muchenxuan Tong, Kun-Hong K.-H. Liu, Chungui Xu, Wenbin Ju Source Type: research
Genome‐wide sequencing of Phytophthora lateralis reveals genetic variation among isolates from Lawson cypress (Chamaecyparis lawsoniana) in Northern Ireland
This article is protected by copyright. All rights reserved. (Source: FEMS Microbiology Letters)
Source: FEMS Microbiology Letters - May 17, 2013 Category: Microbiology Authors: Lisa Quinn, Paul A. O'Neill, James Harrison, Konrad H. Paskiewicz, Alistair R. McCracken, Louise R. Cooke, Murray R. Grant, David J. Studholme Tags: Research Letter Source Type: research
Chemical-genetic identification of the biochemical targets of polyalkylguanidinium biocides
Org. Biomol. Chem., 2013, Accepted ManuscriptDOI: 10.1039/C3OB40593A, PaperDrew Bowie, Paria Parvizi, Dustin Duncan, Christopher J. Nelson, T M FylesAlkylated guanidinium compounds exhibit microbiocidal activity in marine environments, yet the mode of action of these compounds has not been defined. A comprehensive chemical-genetic approach in budding yeast was used...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)
Source: RSC - Organic Biomolecular Chemistry - May 17, 2013 Category: Molecular Biology Authors: Drew Bowie Source Type: research
Heme‐related gene expression signatures of meat intakes in lung cancer tissues
Abstract Lung cancer causes more deaths worldwide than any other cancer. In addition to cigarette smoking, dietary factors may contribute to lung carcinogenesis. Epidemiologic studies, including the environment and genetics in lung cancer etiology (EAGLE), have reported increased consumption of red/processed meats to be associated with higher risk of lung cancer. Heme–iron toxicity may link meat intake with cancer. We investigated this hypothesis in meat‐related lung carcinogenesis using whole genome expression. We measured genome‐wide expression (HG‐U133A) in 49 tumor and 42 non‐involved fresh frozen lung tissue...
Source: Molecular Carcinogenesis - May 17, 2013 Category: Molecular Biology Authors: Tram Kim Lam, Melissa Rotunno, Brid M. Ryan, Angela C. Pesatori, Pier Alberto Bertazzi, Margaret Spitz, Neil E. Caporaso, Maria Teresa Landi Tags: Research Article Source Type: research
Cortical‐striatal gene expression in neonatal hippocampal lesion‐amplified cocaine sensitization
Abstract Cortical‐striatal circuit dysfunction in mental illness may enhance addiction vulnerability. Neonatal ventral hippocampal lesions (NVHL) model this dual diagnosis causality by producing a schizophrenia syndrome with enhanced responsiveness to addictive drugs. Rat genome‐wide microarrays containing >24,000 probsets were used to examine separate and co‐occurring effects of NVHLs and cocaine sensitization (15 mg/kg/day x 5 days) on gene expression within medial prefrontal cortex (MPFC), nucleus accumbens (NAC), and caudate‐putamen (CAPU). Two weeks after NVHLs robustly amplified cocaine behavioral sens...
Source: Genes, Brain and Behavior - May 17, 2013 Category: Genetics & Stem Cells Authors: R. Andrew Chambers, Jeanette N. McClintick, Alena M. Sentir, Sarah A. Berg, Matthew Runyan, Kwang Ho Choi, Howard J. Edenberg Tags: Original Article Source Type: research
Progress in understanding mood disorders: optogenetic dissection of neural circuits
Abstract Major depression is characterized by a cluster of symptoms that includes hopelessness, low mood, feelings of worthlessness, and inability to experience pleasure. The lifetime prevalence of major depression approaches 20%, yet current treatments are often inadequate both because of associated side effects and because they are ineffective for many people. In basic research, animal models are often used to study depression. Typically, experimental animals are exposed to acute or chronic stress to generate a variety of depression‐like symptoms. Despite its clinical importance, very little is known about the cellular...
Source: Genes, Brain and Behavior - May 17, 2013 Category: Genetics & Stem Cells Authors: Stephan Lammel, Kay M. Tye, Melissa R. Warden Tags: Review Article Source Type: research
Characterization of X‐linked Hypohidrotic Ectodermal Dysplasia (XL‐HED) Hair and Sweat Gland Phenotypes Using Phototrichogram Analysis and Live Confocal Imaging
Abstract Hypohidrotic ectodermal dysplasia (HED) is the most common type of ectodermal dysplasia (ED), which encompasses a large group of syndromes that share several phenotypic features such as missing or malformed ectodermal structures, including skin, hair, sweat glands, and teeth. X‐linked hypohidrotic ectodermal dysplasia (XL‐HED) is associated with mutations in ectodysplasin (EDA1). Hypohidrosis due to hypoplastic sweat glands and thin, sparse hair are phenotypic features that significantly affect the daily lives of XL‐HED individuals and therefore require systematic analysis. We sought to determine the quality...
Source: American Journal of Medical Genetics Part A - May 17, 2013 Category: Genetics & Stem Cells Authors: Kyle B. Jones, Alice F. Goodwin, Maya Landan, Kerstin Seidel, Dong‐Kha Tran, Jacob Hogue, Miquella Chavez, Mary Fete, Wenli Yu, Tarek Hussein, Ramsey Johnson, Kenneth Huttner, Andrew H. Jheon, Ophir D. Klein Tags: Research Article Source Type: research
Invariant NKT cell activation induces neutrophil accumulation and hepatitis: Oppositely regulated by IL‐4 and IFN‐γ
Conclusions: Our results propose a model in which activated iNKT cells rapidly release IL‐4, which promotes neutrophil survival and hepatitis but also sequentially produce IFN‐γ, which acts in a negative feedback loop to ameliorate iNKT hepatitis by inducing neutrophil apoptosis. Thus, modification of iNKT production of IL‐4 and IFN‐γ may have the potential to improve the efficacy of α‐Galcer in the treatment of liver disease. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - May 17, 2013 Category: Internal Medicine Authors: Hua Wang, Dechun Feng, Ogyi Park, Shi Yin, Bin Gao Tags: Liver Biology and Pathobiology Source Type: research
Molecular genetic testing and the future of clinical genomics
Nature Reviews Genetics 14, 415 (2013). doi:10.1038/nrg3493 Authors: Sara Huston Katsanis & Nicholas Katsanis Genomic technologies are reaching the point of being able to detect genetic variation in patients at high accuracy and reduced cost, offering the promise of fundamentally altering medicine. Still, although scientists and policy advisers grapple with how to interpret and how to handle the onslaught (Source: Nature Reviews Genetics)
Source: Nature Reviews Genetics - May 17, 2013 Category: Genetics & Stem Cells Authors: Sara Huston KatsanisNicholas Katsanis Tags: Review Source Type: research
Mechanisms and models of somatic cell reprogramming
Nature Reviews Genetics 14, 427 (2013). doi:10.1038/nrg3473 Authors: Yosef Buganim, Dina A. Faddah & Rudolf Jaenisch Conversion of somatic cells to pluripotency by defined factors is a long and complex process that yields embryonic-stem-cell-like cells that vary in their developmental potential. To improve the quality of resulting induced pluripotent stem cells (iPSCs), which is important for potential therapeutic applications, and to (Source: Nature Reviews Genetics)
Source: Nature Reviews Genetics - May 17, 2013 Category: Genetics & Stem Cells Authors: Yosef BuganimDina A. FaddahRudolf Jaenisch Tags: Review Source Type: research
Adjuvant gemcitabine therapy improves survival in a locally induced, r0‐resectable model of metastatic intrahepatic cholangiocarcinoma
Conclusion: we have developed a murine model of single, R0‐resectable ICC with favorable characteristics for the study of recurrence patterns and mechanisms of metastasis after resection. This model holds great promise for preclinical evaluation of novel multimodal or adjuvant therapies to prevent recurrence and metastasis after R0‐resection. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - May 17, 2013 Category: Internal Medicine Authors: Engin Gürlevik, Bettina Fleischmann‐Mundt, Nina Armbrecht, Thomas Longerich, Norman Woller, Arnold Kloos, Dirk Hoffmann, Axel Schambach, Thomas C. Wirth, Michael P. Manns, Lars Zender, Stefan Kubicka, Florian Kühnel Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research
Genetic and functional characterization of culturable plant‐beneficial actinobacteria associated with yam rhizosphere
Abstract Actinobacteria were isolated from the rhizosphere of yam plants from agricultural fields from Yeoju, South Korea and analyzed for their genetic and plant‐beneficial functional diversity. A total of 29 highly occurring actinobacterial isolates from the yam rhizosphere were screened for various plant‐beneficial traits such as antimicrobial activity on fungi and bacteria; biocontrol traits such as production of siderophore, protease, chitinase, endo‐cellulase, and β‐glucanase. The isolates were also screened for plant growth‐promoting (PGP) traits such as auxin production, phosphate solubilization, 1‐ami...
Source: Journal of Basic Microbiology - May 17, 2013 Category: Microbiology Authors: Sasikumar Arunachalam Palaniyandi, Seung Hwan Yang, Karthiyaini Damodharan, Joo‐Won Suh Tags: Research Paper Source Type: research
Genetic and functional diversity of fluorescent Pseudomonas from rhizospheric soils of wheat crop
Abstract Wheat rhizospheric soils were collected from different part of northern and eastern Indo‐Gangetic plains, which is being irrigated from water of Ganga River. Isolation of fluorescent Pseudomonas species was carried out from the soil samples collected. The percentage of isolates positive for indolic compound, P‐solubilisation, siderophore production and ACC deaminase activity were 64.0, 38.6, 63.5, and 19.7, respectively. A total of 543 isolates were randomly selected for studies based on the genus specific confirmation by the Pseudomonas specific primer. Among the 543 isolates, 26 different clusters were forme...
Source: Journal of Basic Microbiology - May 17, 2013 Category: Microbiology Authors: Subhash Yadav, Shivani Yadav, Rajeev Kaushik, Anil K. Saxena, Dilip K. Arora Tags: Research Paper Source Type: research
HTLV-1 cosmopolitan and HTLV-2 subtype b among pregnant women of non-endemic areas of Argentina
Conclusions HTLV-1/2, which have been associated with different diseases, are circulating among PW of Argentina, even in non-endemic areas. Therefore, testing should be recommended in women who have risk factors for these infections given that the majority of HTLV-1/2 mother to child transmission can be prevented by the avoidance of breast feeding. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - May 17, 2013 Category: Sexual Medicine Authors: Berini, C. A., Delfino, C., Torres, O., Garcia, G., Espejo, R., Pianciola, L., Juarez, M., Arribere, G., Nadal, M., Eirin, M. E., Biglione, M. M. Tags: Liver disease, Drugs: infectious diseases, Hepatitis and other GI infections, HIV/AIDS, Travel medicine, Tropical medicine (infectious diseases), Pregnancy, Reproductive medicine, Child health, Hepatitis (sexual health), HIV / AIDS, HIV infections Epide Source Type: research
Riding the wave of ependymal cilia: Genetic susceptibility to hydrocephalus in primary ciliary dyskinesia
Congenital hydrocephalus is a relatively common and debilitating birth defect with several known physiological causes. Dysfunction of motile cilia on the ependymal cells that line the ventricular surface of the brain can result in hydrocephalus by hindering the proper flow of cerebrospinal fluid. As a result, hydrocephalus can be associated with primary ciliary dyskinesia, a rare pediatric syndrome resulting from defects in ciliary and flagellar motility. Although the prevalence of hydrocephalus in primary ciliary dyskinesia patients is low, it is a common hallmark of the disease in mouse models, suggesting that distinct g...
Source: Journal of Neuroscience Research - May 17, 2013 Category: Neuroscience Authors: Lance Lee Tags: Review Source Type: research
Genomics-Driven Oncology: Framework for an Emerging Paradigm [REVIEW ARTICLES]
A majority of cancers are driven by genomic alterations that dysregulate key oncogenic pathways influencing cell growth and survival. However, the ability to harness tumor genetic information for its full clinical potential has only recently become manifest. Over the past several years, the convergence of discovery, technology, and therapeutic development has created an unparalleled opportunity to test the hypothesis that systematic knowledge of genomic information from individual tumors can improve clinical outcomes for many patients with cancer. Rigorous evaluation of this genomics-driven cancer medicine hypothesis will ...
Source: Journal of Clinical Oncology - May 17, 2013 Category: Cancer & Oncology Authors: Garraway Tags: Chromosomal Abnormalities, Gene Expression and Profiling, Growth Factors & Receptor, Immunology/Immunobiology REVIEW ARTICLES Source Type: research
Existing and Emerging Technologies for Tumor Genomic Profiling [REVIEW ARTICLES]
Ongoing global genome characterization efforts are revolutionizing our knowledge of cancer genomics and tumor biology. In parallel, information gleaned from these studies on driver cancer gene alterations—mutations, copy number alterations, translocations, and/or chromosomal rearrangements—can be leveraged, in principle, to develop a cohesive framework for individualized cancer treatment. These possibilities have been enabled, to a large degree, by revolutionary advances in genomic technologies that facilitate systematic profiling for hallmark cancer genetic alterations at increasingly fine resolutions. Ongoing...
Source: Journal of Clinical Oncology - May 17, 2013 Category: Cancer & Oncology Authors: MacConaill Tags: REVIEW ARTICLES Source Type: research
Clinical Analysis and Interpretation of Cancer Genome Data [REVIEW ARTICLES]
We describe existing knowledge bases, databases, algorithms, and tools for identification and visualization of tumor variants and their actionable subsets. With the decreasing cost of tumor gene mutation testing and the increasing number of actionable therapeutics, we expect the methods for analysis and interpretation of cancer genomes to continue to evolve to meet the needs of patient-centered clinical decision making. The science of computational cancer medicine is still in its infancy; however, there is a clear need to continue the development of knowledge bases, best practices, tools, and validation experiments for suc...
Source: Journal of Clinical Oncology - May 17, 2013 Category: Cancer & Oncology Authors: Van Allen, Wagle, Levy Tags: Cancer Biomarkers, Chromosomal Abnormalities, Gene Expression and Profiling, Growth Factors & Receptor REVIEW ARTICLES Source Type: research
Ethical, Legal, and Counseling Challenges Surrounding the Return of Genetic Results in Oncology [REVIEW ARTICLES]
In the last decade, an overwhelming number of genetic aberrations have been discovered and linked to the development of treatment for cancer. With the rapid advancement of next-generation sequencing (NGS) techniques, it is expected that large-scale DNA analyses will increasingly be used to select patients for treatment with specific anticancer agents. Personalizing cancer treatment has many advantages, but sequencing germline DNA as reference material for interpreting cancer genetics may have consequences that extend beyond providing cancer care for an individual patient. In sequencing germline DNA, mutations may be encoun...
Source: Journal of Clinical Oncology - May 17, 2013 Category: Cancer & Oncology Authors: Lolkema, Gadellaa-van Hooijdonk, Bredenoord, Kapitein, Roach, Cuppen, Knoers, Voest Tags: Ethics REVIEW ARTICLES Source Type: research
Building a Personalized Medicine Infrastructure at a Major Cancer Center [REVIEW ARTICLES]
This article will focus on the challenges and opportunities that accompany the building of infrastructure for personalized cancer therapy. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 17, 2013 Category: Cancer & Oncology Authors: Meric-Bernstam, Farhangfar, Mendelsohn, Mills Tags: REVIEW ARTICLES Source Type: research