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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

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You may have wondered why this journal is the Archives of Gerontology and Geriatrics. Around two and a half thousand years ago Hippocrates pondered on whether old age was a natural or pathological condition (see , for a historical perspective from antiquity to the mid-twentieth century). In modern times, led by the UK, an increasing distinction has been made between medical treatment of older adults and the process of aging (, describe the development of modern geriatric medicine in the UK in some detail). Overshadowing this development were what became to be known as Bernard Isaac's “Geriatric Giants” of Instability, ...
Source: Archives of Gerontology and Geriatrics - January 25, 2013 Category: Geriatrics Authors: John M. Starr Source Type: research

Flexible‐Dose Fesoterodine in Elderly Adults with Overactive Bladder: Results of the Randomized, Double‐Blind, Placebo‐Controlled Study of Fesoterodine in an Aging Population Trial
ConclusionFesoterodine was associated with significantly greater improvements in most diary variables and participant‐reported outcomes than placebo and was generally well tolerated in older people.
Source: Journal of the American Geriatrics Society - January 25, 2013 Category: Geriatrics Authors: Adrian Wagg, Vik Khullar, Daniela Marschall‐Kehrel, Martin C. Michel, Matthias Oelke, Amanda Darekar, Caty E. Bitoun, David Weinstein, Ian Osterloh Tags: Clinical Investigations Source Type: research

Associations Between Visual, Hearing, and Dual Sensory Impairments and History of Motor Vehicle Collision Involvement of Older Drivers
ConclusionOlder drivers with dual sensory impairment are at greater MVC risk than those with a visual acuity or hearing deficit alone. A combined screening approach of screening for hearing and visual impairment may be a useful tool to identify older drivers at risk of MVC involvement.
Source: Journal of the American Geriatrics Society - January 25, 2013 Category: Geriatrics Authors: Kimberly A. Green, Gerald McGwin, Cynthia Owsley Tags: Brief Reports Source Type: research

Advance Care Planning and the Quality of End‐of‐Life Care in Older Adults
ConclusionACP was associated with improved quality of care at the end of life, including less in‐hospital death and increased use of hospice. Having an AD, assigning a DPOA and conducting ACP discussions are all important elements of ACP.
Source: Journal of the American Geriatrics Society - January 25, 2013 Category: Geriatrics Authors: Kara E. Bischoff, Rebecca Sudore, Yinghui Miao, Walter John Boscardin, Alexander K. Smith Tags: Clinical Investigations Source Type: research

Discriminative Ability and Predictive Validity of the Timed Up and Go Test in Identifying Older People Who Fall: Systematic Review and Meta‐Analysis
ConclusionThe findings suggest that the TUG is not useful for discriminating fallers from non‐fallers in healthy, high‐functioning older people but is of more value in less‐healthy, lower‐functioning older people. Overall, the predictive ability and diagnostic accuracy of the TUG are at best moderate. No cut‐point can be recommended. Quick, multifactorial fall risk screens should be considered to provide additional information for identifying older people at risk of falls.
Source: Journal of the American Geriatrics Society - January 25, 2013 Category: Geriatrics Authors: Daniel Schoene, Sandy M.‐S. Wu, A. Stefanie Mikolaizak, Jasmine C. Menant, Stuart T. Smith, Kim Delbaere, Stephen R. Lord Tags: Clinical Investigations Source Type: research

The Unknown Profession: A Geriatrician
The term “plastic surgeon” is oddly uninformative, although it seems likely that most people know what plastic surgeons do. How well can a sample of individuals encountered on the street describe what geriatricians do? To answer this question, we strolled through downtown Baltimore's Inner Harbor, armed with a video camera and picture identification cards to ask the following question: “What is a geriatrician?” Two of us (PA, JY), from the Johns Hopkins Division of Geriatric Medicine and Gerontology, surveyed a convenience sample of people aged 18–80. To further enhance this survey, a video of the interviews was...
Source: Journal of the American Geriatrics Society - January 25, 2013 Category: Geriatrics Authors: Jean Y. Campbell, Samuel C. Durso, Lynsey E. Brandt, Thomas E. Finucane, Peter M. Abadir Tags: Special Articles Source Type: research

Antihypertensive Therapy and Cerebral Hemodynamics in Executive Mild Cognitive Impairment: Results of a Pilot Randomized Clinical Trial
ConclusionAngiotensin receptor blockers may preferentially preserve cerebral hemodynamics and executive function in individuals with executive dysfunction. These findings warrant further investigation in a larger trial.
Source: Journal of the American Geriatrics Society - January 25, 2013 Category: Geriatrics Authors: Ihab Hajjar, Meaghan Hart, Yu‐Ling Chen, Wendy Mack, Vera Novak, Helena C. Chui, Lewis Lipsitz Tags: Clinical Investigations Source Type: research

Frailty and Fracture, Disability, and Falls: A Multiple Country Study From the Global Longitudinal Study of Osteoporosis in Women
ConclusionGreater evidence of a frailty phenotype is associated with greater risk of fracture, disability, and falls in women aged 55 and older in 10 countries, with similar patterns across age and geographic region.
Source: Journal of the American Geriatrics Society - January 25, 2013 Category: Geriatrics Authors: Sarah E. Tom, Jonathan D. Adachi, Frederick A. Anderson, Steven Boonen, Roland D. Chapurlat, Juliet E. Compston, Cyrus Cooper, Stephen H. Gehlbach, Susan L. Greenspan, Frederick H. Hooven, Jeri W. Nieves, Johannes Pfeilschifter, Christian Roux, Stuart Sil Tags: Clinical Investigations Source Type: research

[Early detection and prevention of elder abuse and neglect in family care giving : Development of the PURFAM assessment.]
[Early detection and prevention of elder abuse and neglect in family care giving : Development of the PURFAM assessment.] Z Gerontol Geriatr. 2013 Jan 25; Authors: Heidenblut S, Schacke C, Zank S Abstract The purpose of the PURFAM ("potentials and risk factors of family caregiving for older people") project is to support staff members of home care services in preventing elder abuse by facilitating an assessment instrument for early recognition and a standard for action. During a pilot phase of the project nursing staff of home services were presented with training sessions in which the use of the PURFAM ass...
Source: Zeitschrift fur Gerontologie und Geriatrie - January 25, 2013 Category: Geriatrics Authors: Heidenblut S, Schacke C, Zank S Tags: Z Gerontol Geriatr Source Type: research

[Psychotherapy of depression in old age.]
Abstract Depression in old age is common and also dangerous due to somatic comorbidity and suicide; however, it is often not recognized and not adequately treated. Psychotherapy is almost never offered to the elderly. However, clinical experience, single-case studies and some controlled trials show effectiveness-at least to the age of 75. The psychotherapist must be aware of unusual transference and countertransference between a younger therapist and elderly patient. Psychotherapy in old age requires some modifications, especially concerning special interest in biography and history, strong empathy, "container func...
Source: Zeitschrift fur Gerontologie und Geriatrie - January 25, 2013 Category: Geriatrics Authors: Wächtler C Tags: Z Gerontol Geriatr Source Type: research

[Neurobiological subtypes of geriatric depression : Their importance for diagnosis and treatment.]
[Neurobiological subtypes of geriatric depression : Their importance for diagnosis and treatment.] Z Gerontol Geriatr. 2013 Jan 25; Authors: Rapp MA Abstract With age, increasing biological constraints on functioning are often aggravated by increases in multimorbidity. These effects, however, not only have an impact on somatic, but also psychological processes. In geriatric depression, for instance, there are both effects of recurrent depressive episodes on the neurobiology of the disorder as well as effects of cardiovascular comorbidity that interact with brain areas associated with the perception and regu...
Source: Zeitschrift fur Gerontologie und Geriatrie - January 25, 2013 Category: Geriatrics Authors: Rapp MA Tags: Z Gerontol Geriatr Source Type: research

[Depression in late life.]
PMID: 23344222 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Gerontologie und Geriatrie - January 25, 2013 Category: Geriatrics Authors: Hewer W, Kopf D Tags: Z Gerontol Geriatr Source Type: research

Mutations in the profilin 1 gene are not common in amyotrophic lateral sclerosis of Chinese origin.
Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily involving the corticospinal tract, brainstem, and anterior cells of the spinal cord. Mutations in the profilin 1 gene (PFN1) were recently described in ALS families. To investigate the spectrum and frequency of PFN1 mutations further, we sequenced all 3 exons of the PFN1 gene in 20 familial ALS index cases, 324 sporadic ALS patients, and 355 healthy control subjects. No nonsynonymous coding variants were identified. Our findings suggest that mutations in the PFN1 gene are not a common cause of ALS in the Chinese popula...
Source: Neurobiology of Aging - January 25, 2013 Category: Geriatrics Authors: Zou ZY, Sun Q, Liu MS, Li XG, Cui LY Tags: Neurobiol Aging Source Type: research

Comparison of Disease Clusters in Two Elderly Populations Hospitalized in 2008 and 2010
Gerontology (DOI:10.1159/000346353)
Source: Gerontology - January 24, 2013 Category: Geriatrics Source Type: research

Community pharmacists and people with dementia: a cross‐sectional survey exploring experiences, attitudes, and knowledge of pain and its management
ConclusionsThe study has revealed that community pharmacists often encounter people with dementia, especially those living in their own homes, and they have positive attitudes towards the patient population. However, training in the assessment and management of pain in people with dementia must be developed to further improve their knowledge in this area. Copyright © 2013 John Wiley & Sons, Ltd.
Source: International Journal of Geriatric Psychiatry - January 24, 2013 Category: Geriatrics Authors: Heather E. Barry, Carole Parsons, A. Peter Passmore, Carmel M. Hughes Tags: Research Article Source Type: research

Comparison of Disease Clusters in Two Elderly Populations Hospitalized in 2008 and 2010
Gerontology (DOI:10.1159/000346353)
Source: Karger Publishers - January 24, 2013 Category: Cancer & Oncology Source Type: research

Tiger Tradeoffs: Balancing Medical and Psychological Well-Being in Zoos
Among animal welfare professionals, those who work at zoos might have the toughest jobs. Keepers and curators at zoo must alternately serve as biologists, psychologists, trainers, chefs, janitors, and educators. Often, those hardworking individuals take on multiple roles at once. Another important job that keepers and curators perform at the zoo is that of gerontologist. Gerontology , or the study of aging, is a field that has only been formally defined for forty years, and is becoming a more important consideration for the welfare of captive animals. [More]
Source: Scientific American - Official RSS Feed - January 24, 2013 Category: Science Tags: Health,Mind & Brain Source Type: research

Patterns of Functional Decline in Hospice: What Can Individuals and Their Families Expect?
ConclusionAlthough functional status generally declines in individuals in hospice, this decline is heterogeneous. Some individuals retain some physical and cognitive function until the last day of life.
Source: Journal of the American Geriatrics Society - January 24, 2013 Category: Geriatrics Authors: Pamela Harris, Esther Wong, Sue Farrington, Teresa R. Craig, Joan K. Harrold, Betty Oldanie, Joan M. Teno, David J. Casarett Tags: Brief Reports Source Type: research

Quality of life in nursing homes following the group-living principle : A pilot study measuring the quality of life from the subjective perspective of dependent-living elderly.
CONCLUSION: The results of the first pilot study in the research field of subjective quality of life in group-living nursing homes are presented. The study focused on very old people with age-specific reduced physical and mental abilities. The NHP should also be considered as a reliable, valid and useful alternative to resident satisfaction surveys. PMID: 23340872 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Gerontologie und Geriatrie - January 24, 2013 Category: Geriatrics Authors: Simon A, Berwig M, Heinrich S Tags: Z Gerontol Geriatr Source Type: research

C9orf72 G(4)C(2) repeat expansions in Alzheimer's disease and mild cognitive impairment.
Abstract C9orf72 G(4)C(2) repeat expansion is a major cause of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Its role in Alzheimer's disease (AD) is less clear. We assessed the prevalence of G(4)C(2) pathogenic repeat expansions in Flanders-Belgian patients with clinical AD or mild cognitive impairment (MCI). In addition, we studied the effect of non-pathogenic G(4)C(2) repeat length variability on susceptibility to AD, and on AD cerebrospinal fluid (CSF) biomarker levels. A pathogenic repeat expansion was identified in 5 of 1217 AD patients (frequency <1%). No pathogenic expansions were o...
Source: Neurobiology of Aging - January 24, 2013 Category: Geriatrics Authors: Cacace R, Van Cauwenberghe C, Bettens K, Gijselinck I, van der Zee J, Engelborghs S, Vandenbulcke M, Van Dongen J, Bäumer V, Dillen L, Mattheijssens M, Peeters K, Cruts M, Vandenberghe R, De Deyn PP, Van Broeckhoven C, Sleegers K Tags: Neurobiol Aging Source Type: research

Physical activity and cardiovascular risk factors at menopause: The Nord-Trøndelag health study.
Conclusion: Increased PA may reduce the risk of adverse outcomes and use of pharmacological management in women of menopausal age. PMID: 23347190 [PubMed - as supplied by publisher]
Source: Climacteric - January 24, 2013 Category: Geriatrics Authors: Gudmundsdottir SL, Flanders WD, Augestad LB Tags: Climacteric Source Type: research

The effect of age and menopausal status on musculoskeletal symptoms in Chinese women aged 35-64 years.
Conclusion: Menopause was known to be a time of increased musculoskeletal symptoms, but the association of musculoskeletal symptoms with age and BMI also should be considered. PMID: 23347340 [PubMed - as supplied by publisher]
Source: Climacteric - January 24, 2013 Category: Geriatrics Authors: Gao HL, Lin SQ, Wei Y, Chen Y, Wu ZL Tags: Climacteric Source Type: research

Does the combined intervention of soy isoflavones extract with mechanical vibration exert synergistic and trophic effects on bone tissue in rats?
Conclusion: the mechanical vibration treatment is more efficient than soy isoflavones in improving bone quality by the increase of bone density, the content sulfated GAGs and the presence of mature collagen fibers. In addition, the combined interventions have partial trophic and synergistic effects that are bone site specific in ovariectomized rats. PMID: 23347380 [PubMed - as supplied by publisher]
Source: Climacteric - January 24, 2013 Category: Geriatrics Authors: Silva RF, Santos MA, Medeiros VP, Nader HB, Nonaka KO, Simões MJ, Reginato RD Tags: Climacteric Source Type: research

Ultra-low-dose estriol and lactobacilli in the local treatment of postmenopausal vaginal atrophy: a double-blind randomized trial followed by open-label maintenance therapy.
Conclusions: The ultra-low dose vaginal 0.03 mg-estriol-lactobacilli combination (Gynoflor(®)) was superior to placebo with respect to change in VMI after the 12-day initial therapy and the maintenance therapy of 2 tablets weekly was sufficient to prevent the relapse of vaginal atrophy. PMID: 23347400 [PubMed - as supplied by publisher]
Source: Climacteric - January 24, 2013 Category: Geriatrics Authors: Jaisamrarn U, Triratanachat S, Chaikittisilpa S, Grob P, Prasauskas V, Taechakraichana N Tags: Climacteric Source Type: research

Violence against rural older women: Promoting community awareness and action
ConclusionsThe insights generated during this project produced a framework on which rural communities can build to address the hidden and growing problem of late life IPV.
Source: Australasian Journal on Ageing: - January 24, 2013 Category: Geriatrics Authors: Karen A Roberto, Nancy Brossoie, Marya C McPherson, Mary Beth Pulsifer, Patricia N Brown Tags: Research Article Source Type: research

Social Ties in the Context of the Continuing Care Retirement Community
In this article, we evaluate social ties in the context of the continuing care retirement community (CCRC). We interviewed 29 CCRC residents and 19 adult children about the transition to the CCRC. We analyzed the interviews thematically, while searching for consistencies and differences regarding social ties within and across interviews. Three major themes were identified: a time dimension, representing the perceived qualities of relationships based on the time during which the relationships were first formed; and two spatial dimensions, representing the CCRC vs. the community at large and private vs. public space and iden...
Source: Qualitative Health Research - January 24, 2013 Category: Global & Universal Authors: Ayalon, L., Green, V. Tags: Articles Source Type: research

White matter fractional anisotropy is inversely related to anxious symptoms in older adults with atherosclerosis
ConclusionsAnxiety symptoms uniquely correlated with low FA in older adults with atherosclerosis. These findings may have implications for future research on the topic of anxiety in aging and vascular disease and warrant replication. Copyright © 2013 John Wiley & Sons, Ltd.
Source: International Journal of Geriatric Psychiatry - January 24, 2013 Category: Geriatrics Authors: Kelly R. Bijanki, Ashley N. Stillman, Stephan Arndt, Vincent A. Magnotta, Jess G. Fiedorowicz, William G. Haynes, Joy T. Matsui, Hans J. Johnson, David J. Moser Tags: Research Article Source Type: research

Bayesian networks: a new method for the modeling of bibliographic knowledge : Application to fall risk assessment in geriatric patients - Lalande L, Bourguignon L, Carlier C, Ducher M.
Falls in geriatry are associated with important morbidity, mortality and high healthcare costs. Because of the large number of variables related to the risk of falling, determining patients at risk is a difficult challenge. The aim of this work was to vali...
Source: SafetyLit: All (Unduplicated) - January 23, 2013 Category: Global & Universal Tags: Age: Elder Adults Source Type: news

NEW: CDC Influenza Update for Geriatricians and Other Clinicians Caring for People 65 and Older
Source: CDC Flu updates - January 23, 2013 Category: Infectious Diseases Source Type: news

'All aboard!' for Ipswich fundraising in aid of Alzheimer's Society
Ipswich bus drivers have supported Alzheimer's Society as their charity of the year.
Source: Alzheimers Society - January 23, 2013 Category: Geriatrics Source Type: news

New Geriatric Assessments Aid Cancer Treatment Decisions
SAN ANTONIO (IMNG) - Breast cancer outcomes haven't improved to nearly the same impressive extent in older women as in younger women, according to Dr. Hyman B. Muss.The reasons for this age-related disparity...
Source: OncologySTAT Latest News - January 23, 2013 Category: Cancer & Oncology Source Type: news

Many thanks to the fundraisers of East Anglia and Central
We want to say a big thank you to our hard-working fundraisers.
Source: Alzheimers Society - January 23, 2013 Category: Geriatrics Source Type: news

'Memorial to Mum' in aid of Alzheimer's Society
An enthusiastic fundraiser in Southend-on-Sea surpasses fundraising targets with even more to come.
Source: Alzheimers Society - January 23, 2013 Category: Geriatrics Source Type: news

Hearing Loss Linked to Mental Decline in Elderly
Title: Hearing Loss Linked to Mental Decline in ElderlyCategory: Health NewsCreated: 1/23/2013 11:00:00 AMLast Editorial Review: 1/23/2013 12:00:00 AM
Source: MedicineNet Alzheimer - January 23, 2013 Category: Geriatrics Source Type: news

Re: Can We Avoid Percutaneous Nephrolithotomy in High-Risk Elderly Patients Using the Charlson Comorbidity Index?
B. Resorlu, A. Diri, A. F. Atmaca, C. Tuygun, D. Oztuna, O. F. Bozkurt and A. Unsal Department of Urology, Kecioren Training and Research Hospital, Ankara, Turkey
Source: The Journal of Urology - January 23, 2013 Category: Urology & Nephrology Authors: Tomas L. Griebling Tags: Geriatrics Source Type: research

Re: Asymptomatic Bacteriuria Among the Elderly Living in the Community: Prevalence, Risk Factors and Characteristics
M. Varli, H. Guruz, S. Aras, A. Yalcin, T. Atli and M. Turgay Department of Geriatric Medicine, Ankara University School of Medicine, Ankara, Turkey
Source: The Journal of Urology - January 23, 2013 Category: Urology & Nephrology Authors: Tomas L. Griebling Tags: Geriatrics Source Type: research

Usefulness of the Geriatric Depression Scale 15-item version among very old people with and without cognitive impairment.
Conclusions: The GDS-15 seems to have an overall usefulness to assess depressive symptoms among very old people with an MMSE score of 10 or more. More studies are needed to strengthen the validity of GDS-15 among older people with MMSE scores of 10-14. For older people with MMSE scores lower than 10, there is a need to develop and validate other measurements. PMID: 23339600 [PubMed - as supplied by publisher]
Source: Aging and Mental Health - January 23, 2013 Category: Geriatrics Authors: Conradsson M, Rosendahl E, Littbrand H, Gustafson Y, Olofsson B, Lövheim H Tags: Aging Ment Health Source Type: research

Person-Centered Care Training in Long-Term Care Settings: Usefulness and Facility of Transfer into Practice.
This study analyzed caregivers' assessment of this approach's usefulness and their capacity, after training, to apply it to care practices. Questionnaires with open-ended questions were administered to caregivers (n= 392) one month after training. Caregivers' answers were categorized using a qualitative approach. Respondents perceive some features of this approach are beyond their reach or in opposition to their beliefs. They reported feeling pressure related to time constraints, their peers and the families of residents. These results indicate that training itself is insufficient to transform practice. Institutions wishin...
Source: Canadian Journal on Aging - January 23, 2013 Category: Geriatrics Authors: Viau-Guay A, Bellemare M, Feillou I, Trudel L, Desrosiers J, Robitaille MJ Tags: Can J Aging Source Type: research

Working memory deficits and related disinhibition of the cAMP/PKA/CREB are alleviated by prefrontal α4β2*-nAChRs stimulation in aged mice.
Abstract The present study investigates in aged mice the working memory (WM) enhancing potential of the selective α4β2* nicotinic receptor agonist S 38232 as compared with the cholinesterase inhibitor donepezil, and their effect on cAMP response element binding protein (CREB) phosphorylation (pCREB) as a marker of neuronal activity. We first showed that aged mice exhibit a WM deficit and an increase of pCREB in the prelimbic cortex (PL) as compared with young mice, whereas no modification appears in the CA1. Further, we showed that systemic administration of S 38232 restored WM in aged mice and alleviated PL CREB...
Source: Neurobiology of Aging - January 23, 2013 Category: Geriatrics Authors: Vandesquille M, Baudonnat M, Decorte L, Louis C, Lestage P, Béracochéa D Tags: Neurobiol Aging Source Type: research

Mutational analysis of FBXO7 gene in Parkinson's disease in a Taiwanese population.
Abstract Mutations in the FBXO7 gene cause an autosomal-recessive early-onset parkinsonism with pyramidal tract signs. Its role in typical Parkinson's disease (PD) without pyramidal features is unclear. We assayed FBXO7 gene in 900 participants comprising 448 PD patients and 452 age- and sex-matched control subjects from Taiwan. The entire FBXO7 coding region and intron-exon boundaries were sequenced. We identified 2 novel missense substitutions, p.Ile87Thr and p.Asp328Arg, in a single heterozygous state in 2 early-onset PD patients individually (1.1% early-onset PD). These 2 variants were not observed in control ...
Source: Neurobiology of Aging - January 23, 2013 Category: Geriatrics Authors: Lin CH, Chen ML, Lai TT, Tai CH, Wu RM Tags: Neurobiol Aging Source Type: research

Longevity for free? Increased reproduction with limited trade-offs in Drosophila melanogaster selected for increased life span.
Abstract Selection for increased life span in Drosophila melanogaster has been shown to correlate with decreased early fecundity and increased fecundity later in life. This phenomenon has been ascribed to the existence of trade-offs in which limited resources can be invested in either somatic maintenance or reproduction. In our longevity selection lines, we did not find such a trade-off. Rather, we find that females have similar or higher fecundity throughout life compared to non-selected controls. To determine whether increased longevity affects responses in other traits, we looked at several stress resistance tra...
Source: Experimental Gerontology - January 23, 2013 Category: Geriatrics Authors: Wit J, Sarup P, Lupsa N, Malte H, Frydenberg J, Loeschcke V Tags: Exp Gerontol Source Type: research

Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans
In this study we demonstrate that leptin activates and induces significantly greater amount of IL-6, TNF-α, and IL-10 by B cells from aged humans as compared to young controls. This is associated with increased leptin-induced phosphorylation of STAT3 (signal transducer and activator of transcription-3) in B cells from aged humans as compared to young subjects. These data suggest that leptin-induced B cell-derived proinflammatory cytokines may play a role in chronic inflammation associated with human aging.
Source: Immunity and Aging - January 23, 2013 Category: Geriatrics Authors: Sudhir GuptaSudhanshu AgrawalSastry Gollapudi Source Type: research

Assessment and Diagnosis of Dementia in Hispanic and Non-Hispanic White Outpatients.
We examined whether (a) neuropsychological test performance (NP) or (b) informant reports of patients' functional abilities or (c) behavioral and psychological symptoms (BPS) predicted dementia diagnoses to different degrees among Hispanic and non-Hispanic Whites (NHWs). DESIGN AND METHODS: Our sample included 444 Hispanic and 444 (randomly selected from 11,081) NHW outpatients diagnosed with normal cognition or dementia at their initial evaluations. We tested for significant ethnic-group differences in dementia diagnosis predictors using NP and the 2 informant reports, covarying for age, sex, and education. RESULTS: When ...
Source: The Gerontologist - January 23, 2013 Category: Geriatrics Authors: Sayegh P, Knight BG Tags: Gerontologist Source Type: research

Improving adjustments for older age in pre-hospital assessment and care
Population estimates projects a significant increase in the geriatric population making elderly trauma patients more common. The geriatric trauma patients experience higher incidence of pre-existing medical conditions, impaired age-dependent physiologic reserve, use potent drugs and suffer from trauma system related shortcomings that influence outcomes. To improve adjustments for older age in pre-hospital assessment and care, several initiatives should be implemented. Decision-makers should make system revisions and introduce advanced point-of-care initiatives to improve outcome after trauma for the elderly.
Source: BioMed Central - January 23, 2013 Category: Journals (General) Authors: Marius Rehn Source Type: research

Ophthalmic drugs as part of polypharmacy in nursing home residents with glaucoma
Source: Drugs and Aging Area: Evidence > Medicines Management > References Background: Glaucoma comprises age-related neurodegenerative diseases of retinal ganglion cells, the worldwide prevalence of which is increasing. Local pharmacotherapy is the primary treatment option, especially in the elderly. But this therapeutic approach may include risks for adverse drug effects and drug-drug interactions, of particular importance in frail nursing home resident populations. Objective: The aim of the present study was to investigate anti-glaucoma pharmacotherapy in nursing home residents in the context of m...
Source: NeLM - Care of Older People - January 23, 2013 Category: Geriatrics Source Type: news

Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans
In this study we demonstrate that leptin activates and induces significantlygreater amount of IL-6, TNF-alpha, and IL-10 by B cells from aged humans as compared toyoung controls. This is associated with increased leptin-induced phosphorylation of STAT3(signal transducer and activator of transcription-3) in B cells from aged humans as comparedto young subjects. These data suggest that leptin-induced B cell-derived proinflammatorycytokines may play a role in chronic inflammation associated with human aging.
Source: Immunity and Aging - January 23, 2013 Category: Geriatrics Authors: Sudhir GuptaSudhanshu AgrawalSastry Gollapudi Source Type: research

Community-based intervention to improve dietary habits and promote physical activity among older adults: a cluster randomized trial
Conclusions: The social health program resulted in improved dietary habits, as measured by food intake frequency, FFS, and DVS, and may improve self-rated health among community-dwelling older adults.Trial registration number: UMIN000007357
Source: BMC Geriatrics - January 23, 2013 Category: Geriatrics Authors: Mika KimuraAi MoriyasuShu KumagaiTaketo FurunaShigeko AkitaShuichi KimuraTakao Suzuki Source Type: research

CTE in Brain Scans of Five Retired NFL Players - Now What?
A paper (PDF) to appear in the February 2013 issue of the American Journal of Geriatric Psychiatry confirms that brain scans (positron-emission tomography or PET) consistent with chronic traumatic encephalopathy have been observed in five former NFL players.
Source: Forbes.com Healthcare News - January 22, 2013 Category: Pharmaceuticals Authors: David Kroll Source Type: news

UCLA study first to image concussion-related abnormal brain proteins in retired NFL players
(For more video clips, visit http://bit.ly/XUGLFI.) Sports-related concussions and mild traumatic brain injuries have grabbed headlines in recent months, as the long-term damage they can cause becomes increasingly evident among both current and former athletes. The Centers for Disease Control and Prevention estimates that millions of these injuries occur each year. Despite the devastating consequences of traumatic brain injury and the large number of athletes playing contact sports who are at risk, no method has been developed for early detection or tracking of the brain pathology associated with these injuri...
Source: UCLA Newsroom: Health Sciences - January 22, 2013 Category: Universities & Medical Training Source Type: news

NFL: PET Scan IDs Brain Damage in Players (CME/CE)
(MedPage Today) -- A new imaging technique has allowed detection of tau protein abnormalities in brains of living retired football players that are identical to the autopsy findings of chronic traumatic encephalopathy (CTE) in deceased athletes, researchers reported.
Source: MedPage Today Geriatrics - January 22, 2013 Category: Geriatrics Source Type: news