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ACOG Calls for Later and Fewer Pap Tests (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women can wait longer to have a first Pap smear and repeat the test less frequently, according to recommendations from the American College of Obstetricians and Gynecologists. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - November 20, 2009 Category: Hematology Source Type: news

Time Breast MRI by Progesterone Level (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Measurement of serum progesterone concentrations can aid in scheduling breast MRI in premenopausal women who do not have regular menses, a small retrospective study found. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - November 20, 2009 Category: Hematology Source Type: news

Surveillance is Safe for Probable Benign Breast Masses (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Short-term follow-up is a reasonable alternative to biopsy of palpable breast lesions with benign imaging features, researchers say. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - November 20, 2009 Category: Hematology Source Type: news

Long-term plasma exchange for severe refractory hypertriglyceridemia: A decade of experience demonstrates safety and efficacyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hypertriglyceridemia (hyperTG) is a common form of dyslipidemia and is frequently associated with premature coronary disease, and when severe, recurrent events of pancreatitis may occur. The management of hyperTG is generally medical (life style modification, medications). Plasma exchange (PE) has been reported to be useful in emergency situations particularly when acute pancreatitis results from extreme hyperTG. To our knowledge, there is only one report on long-term use of PE for hyperTG. We here report our results of long-term treatment of hyperTG in 6 patients with Frederickson Type V hyperlipidemia who had recurrent a...
Source: Journal of Clinical Apheresis - November 20, 2009 Category: Hematology Authors: Michal Schaap-Fogler, Daniel Schurr, Tova Schaap, Eran Leitersdorf, Deborah Rund Source Type: journals

Breast Cancer Screening: New Fuel for an Old War of Words and DataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A controversy that has alternately simmered and boiled for more than 40 years reached a flash point this week when the U.S. Preventive Services Task Force published recommendations for breast cancer screening with mammography. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - November 19, 2009 Category: Hematology Source Type: news

Response: MHC class I chain-related gene A (MICA) in unrelated donor transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Blood)
Source: Blood - November 19, 2009 Category: Hematology Authors: Fernandez-Vina, M., Parmar, S., Champlin, R., de Lima, M. Tags: CORRESPONDENCE Source Type: journals

Limited role of MHC class I chain-related gene A (MICA) typing in assessing graft-versus-host disease risk after fully human leukocyte antigen-matched unrelated donor transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Blood)
Source: Blood - November 19, 2009 Category: Hematology Authors: Anderson, E., Grzywacz, B., Wang, H., Wang, T., Haagenson, M., Spellman, S., Blazar, B. R., Miller, J. S., Verneris, M. R. Tags: CORRESPONDENCE Source Type: journals

Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpuraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study the functional and structural role of a recently identified ADAMTS13 metalloprotease domain mutation S119F was investigated. Secretion from heterologous cells was hampered but not completely eliminated. Secreted S119F was active toward multimeric VWF and FRETS-VWF73 but with abnormal kinetics, having a significantly reduced overall catalytic rate (kcat; 0.88 ± 0.04 s–1 vs 2.78 ± 0.11 s–1) and slightly smaller Michaelis constant (KM; 1.4 ± 0.2µM vs 2.3 ± 0.3µM). A computational model of the metalloprotease domain demonstrates both steric and polar interaction...
Source: Blood - November 19, 2009 Category: Hematology Authors: Feys, H. B., Pareyn, I., Vancraenenbroeck, R., De Maeyer, M., Deckmyn, H., Van Geet, C., Vanhoorelbeke, K. Tags: Thrombosis and Hemostasis, Brief Reports Source Type: journals

A role for thrombin in the initiation of the immune response to therapeutic factor VIIIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Administration of human factor VIII (FVIII) to FVIII knockout hemophilia mice is a useful small animal model to study the physiologic response in patients iatrogenically immunized to this therapeutic protein. These mice manifest a robust, T cell–dependent, antibody response to exogenous FVIII treatment, even when encountered through traditionally tolerogenic routes. Thus, FVIII given via these routes elicits both T- and B-cell responses, whereas a control, foreign protein, such as ovalbumin (OVA), is poorly immunogenic. When FVIII is heat inactivated, it loses function and much of its immunogenicity. This suggests th...
Source: Blood - November 19, 2009 Category: Hematology Authors: Skupsky, J., Zhang, A.-H., Su, Y., Scott, D. W. Tags: Immunobiology, Thrombosis and Hemostasis Source Type: journals

Platelet protein disulfide isomerase is localized in the dense tubular system and does not become surface expressed after activationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Evidence is accumulating that circulating tissue factor (TF) contributes to the initiation of coagulation and the formation of fibrin. The majority of circulating TF is cryptic, and it has been suggested that close vicinity with anionic phospholipids on the cell surface increases the active conformation of TF. Two recent papers have shown that encryption of TF and initiation of coagulation are facilitated by the enzyme protein disulfide isomerase (PDI), possibly on the surface of activated platelets or endothelial cells. In this brief report, we demonstrate that the majority of PDI in platelets is intracellular where it is...
Source: Blood - November 19, 2009 Category: Hematology Authors: van Nispen tot Pannerden, H. E., van Dijk, S. M., Du, V., Heijnen, H. F. G. Tags: Platelets and Thrombopoiesis, Thrombosis and Hemostasis, Brief Reports Source Type: journals

Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIPEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The role of the Wiskott-Aldrich syndrome protein (WASp) in platelet function is unclear because platelets that lack WASp function normally. WASp constitutively associates with WASp-interacting protein (WIP) in resting and activated platelets. The role of WIP in platelet function was investigated using mice that lack WIP or WASp. WIP knockout (KO) platelets lack WASp and thus are double deficient. WIP KO mice have a thrombocytopenia, similar to WASp KO mice, resulting in part from enhanced platelet clearance. Most WIP KO, but not WASp KO, mice evolved platelet-associated immunoglobulins (Ig) of the IgA class, which normaliz...
Source: Blood - November 19, 2009 Category: Hematology Authors: Falet, H., Marchetti, M. P., Hoffmeister, K. M., Massaad, M. J., Geha, R. S., Hartwig, J. H. Tags: Platelets and Thrombopoiesis Source Type: journals

The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neutrophils play a vital role in the immune defense, which is evident by the severity of neutropenia causing life-threatening infections. Granulocyte macrophage-colony stimulating factor (GM-CSF) controls homeostatic and emergency development of granulocytes. However, little is known about the contribution of the downstream mediating transcription factors signal transducer and activator of transcription 5A and 5B (STAT5A/B). To elucidate the function of this pathway, we generated mice with complete deletion of both Stat5a/b genes in hematopoietic cells. In homeostasis, peripheral neutrophils were markedly decreased in thes...
Source: Blood - November 19, 2009 Category: Hematology Authors: Kimura, A., Rieger, M. A., Simone, J. M., Chen, W., Wickre, M. C., Zhu, B.-M., Hoppe, P. S., O'Shea, J. J., Schroeder, T., Hennighausen, L. Tags: Hematopoiesis and Stem Cells, Phagocytes, Granulocytes, and Myelopoiesis Source Type: journals

Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: implications for the tumor microenvironment and immunotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An important hallmark of cancer progression is the ability of tumor cells to evade immune recognition. Understanding the relationship between neoplastic cells and the immune microenvironment should facilitate the design of improved immunotherapies. Here we identify impaired T-cell immunologic synapse formation as an active immunosuppressive mechanism in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). We found a significant reduction in formation of the F-actin immune synapse in tumor-infiltrating T cells (P < .01) from lymphoma patients compared with age-matched healthy donor cells. Peripheral blood ...
Source: Blood - November 19, 2009 Category: Hematology Authors: Ramsay, A. G., Clear, A. J., Kelly, G., Fatah, R., Matthews, J., MacDougall, F., Lister, T. A., Lee, A. M., Calaminici, M., Gribben, J. G. Tags: Immunobiology, Lymphoid Neoplasia Source Type: journals

TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined whether TAPP can regulate cell adhesion, a known function of utrophin/syntrophin in other cell types. Expression of membrane-targeted TAPP2 enhanced B-cell adhesion to fibronectin and laminin, whereas PH domain–mutant TAPP2 inhibited adhesion. siRNA knockdown of TAPP2 or utrophin, or treatment with PI3K inhibitors, significantly inhibited adhesion. These findings identify TAPP2 as a novel link between PI3K signaling and the cytoskeleton with potential relevance for leukemia progression. (Source: Blood)
Source: Blood - November 19, 2009 Category: Hematology Authors: Costantini, J. L., Cheung, S. M. S., Hou, S., Li, H., Kung, S. K., Johnston, J. B., Wilkins, J. A., Gibson, S. B., Marshall, A. J. Tags: Lymphoid Neoplasia Source Type: journals

Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single-agent cladribine and with more aggressive behaviorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hairy cell leukemia (HCL) is generally responsive to single-agent cladribine, and only a minority of patients are refractory and with poor prognosis. HCLs generally express mutated (M) and, in a minority, unmutated (UM) IGHV. In a multicenter clinical trial in newly diagnosed HCL, we prospectively investigated clinical and molecular parameters predicting response and event-free survival after single-agent cladribine. Of 58 HCLs, 6 expressed UM-IGHV (UM-HCL) and 52 M-IGHV (M-HCL). Beneficial responses were obtained in 53 of 58 patients (91%), whereas treatment failures were observed in 5 of 58 patients (9%). Failures were a...
Source: Blood - November 19, 2009 Category: Hematology Authors: Forconi, F., Sozzi, E., Cencini, E., Zaja, F., Intermesoli, T., Stelitano, C., Rigacci, L., Gherlinzoni, F., Cantaffa, R., Baraldi, A., Gallamini, A., Zaccaria, A., Pulsoni, A., Gobbi, M., Tassi, M., Raspadori, D., Leoncini, L., Rinaldi, A., Sabattini, E. Tags: Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: journals

VH4-34+ hairy cell leukemia, a new variant with poor prognosis despite standard therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hairy cell leukemia variant (HCLv) presents with high disease burden, lack of typical antigens like CD25, and poor response to standard treatments like cladribine. Occasionally, patients with classic HCL respond poorly. Clinical and molecular features of HCL and HCLv has not been compared. Rearrangements expressing immunoglobulin VH chain were sequenced, including 22 from 20 patients with HCLv and 63 from 62 patients with classic HCL. Most patients were seeking relapsed/refractory trials, representing a poor-prognosis population. VH4-34, a gene commonly used in autoimmune disorders, was observed in 8 (40%) HCLv and 6 (10%)...
Source: Blood - November 19, 2009 Category: Hematology Authors: Arons, E., Suntum, T., Stetler-Stevenson, M., Kreitman, R. J. Tags: Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: journals

High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although activation of the B-cell receptor (BCR) signaling pathway is implicated in the pathogenesis of chronic lymphocytic leukemia (CLL), its clinical impact and the molecular correlates of such response are not clearly defined. T-cell leukemia 1 (TCL1), the AKT modulator and proto-oncogene, is differentially expressed in CLL and linked to its pathogenesis based on CD5+ B-cell expansions arising in TCL1-transgenic mice. We studied here the association of TCL1 levels and its intracellular dynamics with the in vitro responses to BCR stimulation in 70 CLL cases. The growth kinetics after BCR engagement correlated strongly w...
Source: Blood - November 19, 2009 Category: Hematology Authors: Herling, M., Patel, K. A., Weit, N., Lilienthal, N., Hallek, M., Keating, M. J., Jones, D. Tags: Lymphoid Neoplasia, Clinical Trials and Observations Source Type: journals

Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study identifies the E-cadherin/catenin complex as a discriminative, partly polyamine-regulated feature of IL-4/IL-13–exposed alternatively activated macrophages that contributes to homotypic and heterotypic cellular interactions. (Source: Blood)
Source: Blood - November 19, 2009 Category: Hematology Authors: Van den Bossche, J., Bogaert, P., van Hengel, J., Guerin, C. J., Berx, G., Movahedi, K., Van den Bergh, R., Pereira-Fernandes, A., Geuns, J. M. C., Pircher, H., Dorny, P., Grooten, J., De Baetselier, P., Van Ginderachter, J. A. Tags: Immunobiology, Phagocytes, Granulocytes, and Myelopoiesis Source Type: journals

The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafishEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The nuclear protein FOG-1 binds transcription factor GATA-1 to facilitate erythroid and megakaryocytic maturation. However, little is known about the function of FOG-1 during myeloid and lymphoid development or how FOG-1 expression is regulated in any tissue. We used in situ hybridization, gain- and loss-of-function studies in zebrafish to address these problems. Zebrafish FOG-1 is expressed in early hematopoietic cells, as well as heart, viscera, and paraspinal neurons, suggesting that it has multifaceted functions in organogenesis. We found that FOG-1 is dispensable for endoderm specification but is required for endoderm...
Source: Blood - November 19, 2009 Category: Hematology Authors: Amigo, J. D., Ackermann, G. E., Cope, J. J., Yu, M., Cooney, J. D., Ma, D., Langer, N. B., Shafizadeh, E., Shaw, G. C., Horsely, W., Trede, N. S., Davidson, A. J., Barut, B. A., Zhou, Y., Wojiski, S. A., Traver, D., Moran, T. B., Kourkoulis, G., Hsu, K., Tags: Hematopoiesis and Stem Cells Source Type: journals

Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profilingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The first adult-repopulating hematopoietic stem cells (HSCs) are detected starting at day 10.5 of gestation in the aorta-gonads-mesonephros (AGM) region of the mouse embryo. Despite the importance of the AGM in initiating HSC production, very little is currently known about the regulators that control HSC emergence in this region. We have therefore further defined the location of HSCs in the AGM and incorporated this information into a spatial and temporal comparative gene expression analysis of the AGM. The comparisons included gene expression profiling (1) in the newly identified HSC-containing region compared with the r...
Source: Blood - November 19, 2009 Category: Hematology Authors: Mascarenhas, M. I., Parker, A., Dzierzak, E., Ottersbach, K. Tags: Hematopoiesis and Stem Cells Source Type: journals

Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, increase in hemoglobin F in sickle cell disease may be associated with relatively lower tissue oxygen delivery as reflected in higher erythropoietin concentration. Greater levels of erythropoietin or hemoglobin F were independently associated with higher tricuspid regurgitation velocity after adjustment for degree of hemolysis, suggesting an independent relationship of hypoxia with higher systolic pulmonary artery pressure. The hemolysis-lowering and hemoglobin F–augmenting effects of hydroxyurea may exert countervailing influences on pulmonary blood pressure in sickle cell disease. (Source: Blood)
Source: Blood - November 19, 2009 Category: Hematology Authors: Gordeuk, V. R., Campbell, A., Rana, S., Nouraie, M., Niu, X., Minniti, C. P., Sable, C., Darbari, D., Dham, N., Onyekwere, O., Ammosova, T., Nekhai, S., Kato, G. J., Gladwin, M. T., Castro, O. L. Tags: Free Research Articles, Red Cells, Iron, and Erythropoiesis, Clinical Trials and Observations Source Type: journals

Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic blood transfusion is increasingly indicated in patients with sickle cell disease. Measuring resulting iron overload remains a challenge. Children without viral hepatitis enrolled in 2 trials for stroke prevention were examined for iron overload (STOP and STOP2; n = 271). Most received desferrioxamine chelation. Serum ferritin (SF) changes appeared nonlinear compared with prechelation estimated transfusion iron load (TIL) or with liver iron concentrations (LICs). Averaged correlation coefficient between SF and TIL (patients/observations, 26 of 164) was r = 0.70; between SF and LIC (patients/observations, 33 of 47) w...
Source: Blood - November 19, 2009 Category: Hematology Authors: Adamkiewicz, T. V., Abboud, M. R., Paley, C., Olivieri, N., Kirby-Allen, M., Vichinsky, E., Casella, J. F., Alvarez, O. A., Barredo, J. C., Lee, M. T., Iyer, R. V., Kutlar, A., McKie, K. M., McKie, V., Odo, N., Gee, B., Kwiatkowski, J. L., Woods, G. M., C Tags: Free Research Articles, Red Cells, Iron, and Erythropoiesis, Clinical Trials and Observations Source Type: journals

How I treat postthrombotic syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Postthrombotic syndrome (PTS) is a chronic complication of deep venous thrombosis (DVT) that reduces quality of life and has important socioeconomic consequences. More than one-third of patients with DVT will develop PTS, and 5% to 10% of patients will develop severe PTS, which may manifest as venous ulceration. The principal risk factors for PTS are persistent leg symptoms 1 month after the acute episode of DVT, extensive DVT, recurrent ipsilateral DVT, obesity, and older age. Daily use of elastic compression stockings (ECSs) for 2 years after proximal DVT appears to reduce the risk of PTS; however, there is uncertainty a...
Source: Blood - November 19, 2009 Category: Hematology Authors: Kahn, S. R. Tags: How I Treat, Free Research Articles, Thrombosis and Hemostasis Source Type: journals

Mechanisms underlying neutrophil-mediated monocyte recruitmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Extravasation of polymorphonuclear leukocytes (PMNs) to the site of inflammation precedes a second wave of emigrating monocytes. That these events are causally connected has been established a long time ago. However, we are now just beginning to understand the molecular mechanisms underlying this cellular switch, which has become even more complex considering the emergence of monocyte subsets, which are affected differently by signals generated from PMNs. PMN granule proteins induce adhesion as well as emigration of inflammatory monocytes to the site of inflammation involving β2-integrins and formyl-peptide receptors....
Source: Blood - November 19, 2009 Category: Hematology Authors: Soehnlein, O., Lindbom, L., Weber, C. Tags: Immunobiology, Phagocytes, Granulocytes, and Myelopoiesis, Review Articles Source Type: journals

Cracking the platelet WIPEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Blood)
Source: Blood - November 19, 2009 Category: Hematology Authors: Poole, A. W. Tags: INSIDE BLOOD Source Type: journals

IG genes and hairy cell leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Blood)
Source: Blood - November 19, 2009 Category: Hematology Authors: Caligaris-Cappio, F. Tags: INSIDE BLOOD Source Type: journals

Macrophage fusion cuisineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Blood)
Source: Blood - November 19, 2009 Category: Hematology Authors: Sica, A., Mantovani, A. Tags: INSIDE BLOOD Source Type: journals

Millennium Initiates First Clinical Trial With The First Oral Proteasome InhibitorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Millennium: The Takeda Oncology Company announced it has further expanded its protein homeostasis program with the initiation of a Phase I clinical trial for an oral formulation of MLN9708, the Company's second-generation proteasome inhibitor. An intravenous formulation of MLN9708 entered clinical trials in March. MLN9708 is the third molecule Millennium has developed from its innovative research in protein homeostasis. (Source: Lymphoma / Leukemia News From Medical News Today)
Source: Lymphoma / Leukemia News From Medical News Today - November 19, 2009 Category: Hematology Tags: Lymphoma / Leukemia / Myeloma Source Type: news

Clinical and Applied Thrombosis/Hemostasis: Instructions for AuthorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Tags: Articles Source Type: journals

A Platelet Defect Modulates Bleeding in Mild Hemophilia: The Tale of 2 BrothersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Lapecorella, M., Santacroce, R., Napolitano, M., Bafunno, V., Favuzzi, G., Longo, V., Grandone, E., Mariani, G., Margaglione, M. Tags: Articles Source Type: journals

Book Review: New Therapeutic Agents in Thrombosis and Thrombolysis. Jane E. Freedman and Joseph Loscalzo, Editors. 3rd ed. New York, London: Informa Healthcare, 2009. 690 pp. $299.95. USBM 13 1420069235. IllustratedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Messmore, H. L., Wehrmacher, W. H. Tags: Articles Source Type: journals

Book Review: Coagulation in Cancer. David Green and Hau C. Kwaan, Editors. New York, NY: Springer Science + Business Media LCC, 2009. 339 pp. Price $129.00Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Messmore, H. L., Wehrmacher, W. H. Tags: Articles Source Type: journals

A Woman With Rectal Sinus and Left Transversal Sinus Thrombosis After Ovarian Stimulation: Case ReportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of dual cerebral vein thrombosis in a woman with prothrombin mutation homozygosity and ovarian hyperstimulation syndrome. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Santoro, R. Tags: Articles Source Type: journals

Acute Massive Pulmonary Embolism With Hemodynamic Compromise Treated Successfully With Thrombolytic Therapy SelcukEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 78 year-old woman presented with a history of 15 days of dyspnea and tachypnea at rest. A distended right ventricle with free-wall hypokinesis and displacement of the interventricular septum toward the left ventricle were shown on echocardiography. The patient suddenly arrested. She underwent cardiac catheterization and selective pulmonary angiography for suspected pulmonary embolism while undergoing cardiopulmonary resuscitation. With the diagnosis of pulmonary embolism confirmed, recombinant tissue plasminogen activator was given immediately in the catheterization room. This case shows how pulmonary embolism can be dia...
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Pala, S., Kahveci, G., Bozok, S. Tags: Articles Source Type: journals

Diffuse Cerebral Infarct Associated With Factor V Leiden and Prothrombin 20210A Mutations in a Patient With Tetralogy of FallotEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 2-year-old girl with tetralogy of Fallot presented with diffuse cranial infarct after cardiac angiography. Heterozygosity for factor V Leiden and prothrombin 20210A mutations were detected. The authors suggest that if thrombosis develops in patients with congenital heart disease, genetic risk factors should be evaluated. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Sipahi, T., Karademir, S., Kuybulu, A., Akar, N. Tags: Articles Source Type: journals

Single Nucleotide Polymorphisms That Affect Homocysteine Levels in Turkish PopulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, single nucleotide polymorphisms (SNPs) involved in homocysteine metabolism such as CT replacement in the 677th nucleotide in 5,10-methylenetetrahydrofolate reductase (MTHFR) enzyme; 68-bp insertion in the 844th nucleotide of cystathionine β-synthase (CBS) enzyme; 6-bp insertion/deletion in the region of 3'UTR in thymidylate synthase (TYMS) enzyme and 19-bp deletion in dihydrofolate reductase (DHFR) enzyme were investigated. The effects of these mutations on homocysteine levels were studied. As a result; we found that TT genotype of MTHFR 677 CT is an influencing factor on homocysteine levels in Turkish ...
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Koc, Y. L., Akar, N. Tags: Articles Source Type: journals

Oxidative Stress and Total Antioxidant Capacity in Diabetic and Nondiabetic Acute Ischemic Stroke PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Free radical formation is the pivotal mechanism of neuronal injury of ischemic and reperfused brain tissue. In healthy individuals, antioxidant activity counterbalances free radical production, but in the case of ischemia, the balance between reactive oxygen species and antioxidant activity is shifted toward free radicals, causing oxidative stress. The aim of this study is to assess total antioxidant capacity (TAC) and oxidative stress in diabetic and nondiabetic acute stroke patients with 2 different stroke subtypes: large and small vessel disease stroke. Sixty-five acute ischemic stroke patients (29 diabetic and 36 nondi...
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Guldiken, B., Demir, M., Guldiken, S., Turgut, N., Turgut, B., Tugrul, A. Tags: Articles Source Type: journals

Effects of rhG-CSF Plus Dexamethasone on Hemostatic Parameters in Healthy Granulocyte Donors: Role of u-PA and Nitric OxideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Granulocyte colony-stimulating factor (G-CSF) is widely used to reduce the risk of infection resulting from neutropenias and to mobilize and collect CD34+ hematopoetic progenitor cells (HPCs) for autologous and allogenic transplantation. The safety of recombinant human G-CSF (rhG-CSF) administration in healthy donors has been investigated in several studies. However, there are limited cumulative data about the effects of rhG-CSF on hemostasis. Hemostatic parameters, including urokinase-type plasminogen activator antigen (u-PA:Ag) and nitric oxide in 17 healthy granulocyte apheresis donors who donated for neutropenic patien...
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Ekmekci, O. B., Ozturk, G., Ekmekci, H., Atay, D., Yanasik, M., Anak, S., Devecioglu, O. Tags: Articles Source Type: journals

Relative Purity of Different Bovine Thrombin PreparationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to compare the relative purity of bovine crude thrombin and its purified forms, namely, thrombin 4A and thrombin 4B (the products of King Pharma, Middleton, Wisconsin) by virtue of the detection of bovine prothrombin-related antigens in these preparations. Bovine prothrombin was administered intravenously to 3 individual rabbits on days 0, 21, 42, 91, 123, and 151 using standard immunologic method. Blood was drawn from each rabbit on days 30, 50, 105, 137, and 165, and the pooled antisera from 3 rabbits were purified to isolate immunoglobulin G (IgG) using protein G affinity columns. Using Western...
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Zhu, H., Hoppensteadt, D., Iqbal, O., Litinas, E., Adiguzel, C., Fareed, J. Tags: Articles Source Type: journals

Venous Thromboembolism in Patients Hospitalized With Thyroid DysfunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, an increased risk of PE, DVT, and VTE was shown in patients with hypothyroidism but not hyperthyroidism. Antithrombotic prophylaxis in patients with severe hypothyroidism, however, should be viewed with caution because of a possible hyperfibrinolytic state in such patients. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Danescu, L. G., Badshah, A., Danescu, S. C., Janjua, M., Marandici, A. M., Matta, F., Yaekoub, A. Y., Malloy, D. J., Stein, P. D. Tags: Articles Source Type: journals

D-Dimers, Thrombin--Antithrombin Complexes, and Risk Factors for Thromboembolism in Hospitalized PatientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions (a) this study is the first to describe the variations of hypercoagulability markers according to a systematic screening of RFs for VTE in inpatients without suspicion of acute VTE, (b) TAT appeared as a less relevant marker of hypercoagulability than D-dimers in internal medicine inpatients, (d) the chronological classification of RFs identified clearly groups at risk for the prethrombotic state, and (d) an increased hypercoagulability state was demonstrated in patients with an association between a recent immobility and increased inflammatory markers. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Pottier, P., Fouassier, M., Hardouin, J.-B., Volteau, C., Planchon, B. Tags: Articles Source Type: journals

The Impact of Prothrombotic Mutations on Factor Consumption in Adult Patients with Severe HemophiliaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
About 10% of patients with severe hemophilia exhibit a milder clinical phenotype with less frequent bleeds. Among many other factors, coinheritance of prothrombotic mutations have been proposed to act as modulators of clinical severity in severe hemophilia. We conducted a study to evaluate the impact of 3 prothrombotic mutations (factor V Leiden, factor II, and methylenetetrahydrofolate reductase mutations) on clinical phenotype of patients with severe hemophilia in our institution. For this purpose we compared the average annual factor concentrate consumption between carriers and noncarriers of prothrombotic mutations. A ...
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Ar, M. C., Baykara, O., Buyru, A. N., Baslar, Z. Tags: Articles Source Type: journals

Utility of the PFA-100 Instrument and the Novel Multiplate Analyzer for the Assessment of Aspirin and Clopidogrel Effects on Platelet Function in Patients With Cardiovascular DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study evaluated the utility of the PFA-100 and the Multiplate analyzer for the assessment of aspirin and clopidogrel effects on platelet function in patients with cardiovascular disease. Platelet function was determined with the PFA-100 using collagen+epinephrine (CEPI) and collagen+adenosine-5’-diphosphate (CADP) cartridges, and with whole blood impedance aggregometry using the Multiplate ASPI and ADP+PG tests (aggregation triggered with arachidonic acid and ADP+ prostaglandin E1, respectively). Four study groups were identified from the 154 patients enrolled: patients without antiplatelet therapy, patients wit...
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Mueller, T., Dieplinger, B., Poelz, W., Haltmayer, M. Tags: Articles Source Type: journals

European Community and US-FDA Approval of Recombinant Human Antithrombin Produced in Genetically Altered GoatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thrombin and factor Xa play a central role in thrombogenesis in both medical and surgical patients. Antithrombin (AT) is the key inhibitor, which controls the action of these enzymes in hypercoagulable states. The AT concentrates prepared from human blood have been used to treat patients with thrombotic disorders and heparin resistance. The AT concentrates are prepared from pooled human plasma and beside limited supply, suffer from viral and other biological contaminants. The availability of recombinant human AT (rhAT) obtained from genetically engineered goats provide a biologically equivalent product that can be used in ...
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Adiguzel, C., Iqbal, O., Demir, M., Fareed, J. Tags: Articles Source Type: journals

Use of Heparin in Women With Early and Late Miscarriages With and Without ThrombophiliaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data support the notion that LMWH is efficacious in patients with recurrent abortions and thrombophilia. We demonstrated the same effect of LMWH in women with unexplained abortions without thrombophilia. The potential mechanism of action of LMWH in early and late abortions warrants further study. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Monien, S., Kadecki, O., Baumgarten, S., Salama, A., Dorner, T., Kiesewetter, H. Tags: Articles Source Type: journals

Effect of Recombinant Activated Factor VII in Critical Bleeding: Clinical Experience of a Single CenterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recombinant activated factor VII (rFVIIa) has been successfully used ‘‘off-label’’ in patients with refractory life-threatening hemorrhage. Intravenous rFVIIa was given to 31 patients unresponsive to standard therapy with blood products and surgical reexploration, who were bleeding due to trauma, surgery, organ transplantation, liver cirrhosis, ruptured uterus. We recorded their coagulation and hematologic profiles, acid-base balance, blood loss, number of red blood cells (RBC), plasma and platelet transfusions, complications, and survival. rFVIIa (mean dose 132.2 ± 56.3 µg/kg) effectiv...
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Sartori, M. T., Imbergamo, S., Zanon, E., Bonaccorso, G., Pittoni, G., Feltracco, P., Ori, C., Pagnan, A., Cella, G. Tags: Articles Source Type: journals

Unexplained Discrepancies in the Activity--Antigen Ratio in Congenital FX Deficiencies With Defects in the Catalytic DomainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Studies on molecular biology have considerably enhanced our understanding of congenital coagulation disorders but have failed so far to supply tools for an adequate classification of defects. In fact, mutations in the same domain may give rise to different phenotypes. Conversely, mutations in different domains, controlled by different exons, may cause similar patterns. The 37 kindreds with congenital factor X (FX) deficiency, known to have a defect in the catalytic domain, have been evaluated in an attempt to investigate the genotype—phenotype relation. Discrepant results were obtained because about half kindreds sho...
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Girolami, A., Scarparo, P., Vettore, S., Candeo, N., Scandellari, R., Lombardi, A.M. Tags: Articles Source Type: journals

Rivaroxaban in Orthopedic Surgery -- A Change of Paradigm?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two selective, orally available anticoagulant agents, although with different targets in the coagulation cascade, have recently been approved in many countries on the indication of prophylaxis against venous thromboembolism (VTE) after major joint arthroplasty. This review discusses mainly the antifactor Xa drug, rivaroxaban, with a focus on the orthopedic trials. Pharmacokinetic characteristics and other clinical development programs with rivaroxaban are briefly reviewed. Although the aim of this article is not to review the direct thrombin inhibitor, dabigatran etexilate, some comparisons are made. For clinical results, ...
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Schulman, S. Tags: Articles Source Type: journals

Anticoagulant Therapy for Acute Venous Thromboembolism: What We Think We Know and What the Data Show for the Timing of Recurrent EventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although heparin is administered to prevent early recurrences of venous thromboembolism (VTE) by preventing new thrombi, allowing old thrombi to attach to venous walls, and covering warfarin until it is therapeutic, heparin largely prevents late recurrences of VTE (after 5 days). The dreaded early occurrence of pulmonary embolism (PE) (on or before day 5) while waiting for the vitamin K antagonist to become antithrombotic did not occur among patients with deep venous thrombosis (DVT), who received acencoumarol alone. Fewer total recurrences resulted if a therapeutic level of heparin was reached within the first 24 hours of...
Source: Clinical and Applied Thrombosis/Hemostasis - November 19, 2009 Category: Hematology Authors: Stein, P. D., Hull, R. D., Matta, F., Yaekoub, A. Y. Tags: Articles Source Type: journals

Neuropathy and Nutritional Supplements SurveyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Drs. Brian Durie and Paul Richardson are conducting a survey of myeloma patients to try and learn more about experience with neuropathy and nutritional supplements. If you would like to help by participating in the survey, click the More button. All responses are anonyomous. No personal identifying information is being collected. Your help would very much be appreciated. Many thanks! (Source: International Myeloma Foundation)
Source: International Myeloma Foundation - November 19, 2009 Category: Hematology Source Type: organizations