Hematology 
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This page shows you the most recent publications within this specialty of the MedWorm directory.
78466 records returned
Abbreviated Radiotherapy Shows Promise in Prostate Ca
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SAN FRANCISCO (MedPage Today) -- Dramatically condensing radiation treatment for early prostate cancer into just five fractions produces good results without much toxicity, an early-phase study suggested. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - February 5, 2012 Category: Hematology Source Type: news
Vaccine Eyed for Early-Stage Prostate CaEmail this article to a colleague.
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SAN FRANCISCO (MedPage Today) -- The immunotherapy agent sipuleucel-T (Provenge) appears safe for use earlier in prostate cancer, researchers found. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - February 4, 2012 Category: Hematology Source Type: news
Bone Drug Slows Mets in Aggressive Prostate CaEmail this article to a colleague.
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SAN FRANCISCO (MedPage Today) -- Denosumab (Xgeva) delays onset of bone metastases for even the highest risk prostate cancer patients, researchers found. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - February 4, 2012 Category: Hematology Source Type: news
Aspirin, Warfarin Fare Equally for Heart Failure PatientsEmail this article to a colleague.
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Each of these anti-clotting drugs had similar effectiveness in preventing deaths, study found (Source: The Doctors Lounge - Cardiology)
Source: The Doctors Lounge - Cardiology - February 4, 2012 Category: Cardiology Authors: webmaster at doctorslounge.com Tags: Cardiology, Family Medicine, Hematology, Neurology, Nursing, Pharmacy, News, Source Type: news
Myeloproliferative NeoplasmsEmail this article to a colleague.
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Critical Concepts and Managementseries:Hematologic MalignanciesMyeloproliferative neoplasms (MPNs) are clonal stem cell diseases that, under the World Health Organization classification, are subcategorized into eight clinicopathologic entities. The current book focuses on three of these categories: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. A number of important questions regarding the diagnosis, prognosis, and treatment of ... (Source: Springer Medicine titles)
Source: Springer Medicine titles - February 3, 2012 Category: Databases & Libraries Tags: Hematology Source Type: news
Robotic Surgery: Ready for Prime Time in Endometrial Cancer?Robotic Surgery: Ready for Prime Time in Endometrial Cancer?Email this article to a colleague.
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Laparoscopic hysterectomy reduces complications and improves quality of life, but it is still not widely embraced, and the benefits of robotic surgery remain unclear. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 3, 2012 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
World Cancer Day Emphasizes PreventionWorld Cancer Day Emphasizes PreventionEmail this article to a colleague.
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World Cancer Day 2012 will focus on preventing cancer and emphasize that up to one third of common cancers can be prevented by lifestyle changes. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 3, 2012 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Lawmaker Calls for Bipartisan Support for Cancer ResearchLawmaker Calls for Bipartisan Support for Cancer ResearchEmail this article to a colleague.
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According to one researcher, cancer is having its AZT moment. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 3, 2012 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
EMR: Efficiency Mauled Repeatedly EMR: Efficiency Mauled RepeatedlyEmail this article to a colleague.
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Dr. John Marshall says that his efficiency as a clinician is undermined as he spends more and more time entering data into the EMR with less and less administrative support. Is there a way out? Medscape Hematology-Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 3, 2012 Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news
Could a Blood Test Help Spot Depression?Email this article to a colleague.
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Small study suggests 'biomarker' levels might help support a diagnosis, but more research needed (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - February 3, 2012 Category: Psychiatry Authors: webmaster at doctorslounge.com Tags: Hematology, Psychiatry, Research, News, Source Type: news
Lung Tumor Grows, but Must Chemo Change?Lung Tumor Grows, but Must Chemo Change?Email this article to a colleague.
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Dr. Mark Kris discusses cancer progression, as defined by RECIST criteria, and the situations in which increased tumor size in NSCLC need not prompt a change in standard chemotherapy. Medscape Hematology-Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 3, 2012 Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news
Leukopenia and thrombocytopenia induced by etanercept: two case reports and literature reviewEmail this article to a colleague.
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We report two cases of bicytopenia induced by etanercept. Both cases recovered after drug withdrawal. We discuss the need of introduction of routine laboratorial tests in patients using anti-TNF therapy, in order to identify possible hematological changes (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - February 3, 2012 Category: Rheumatology Source Type: research
Caregiver burden among nocturnal home hemodialysis patientsEmail this article to a colleague.
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AbstractRecent studies have suggested improvements in quality of life (QOL) in patients on quotidian dialysis compared with conventional hemodialysis. Few studies have focused on the burden and QOL in caregivers of patients with end‐stage renal disease (ESRD) on nocturnal home hemodialysis (NHD). We aim to assess the caregivers’ burden, QOL, and depressive symptoms and to compare these parameters with their patients’ counterparts. Cross‐sectional surveys were sent to 61 prevalent NHD patients and their caregivers. Surveys assessed demographics, general self‐perceived health using the 12‐Item Short Form Health S...
Source: Hemodialysis International - February 3, 2012 Category: Hematology Authors: Jean‐Philippe RiouxRanjit NarayananChristopher T. Chan Tags: Original Article Source Type: research
Necrotizing fasciitis of thigh associated with EscherichiaColi bacteremia in a patient on chronic hemodialysisEmail this article to a colleague.
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We present a 59‐year‐old male on chronic hemodialysis (HD). We made the diagnosis of necrotizing fasciitis of the right thigh due to the crepitus from physical examination and subcutaneous emphysema from an X film. He was successfully treated with antibiotics and surgical debridement. The blood and surgical drainage cultures showed Escherichia coli, which is less commonly seen in cutaneous infection. The colonoscopic finding revealed adenomatous polyps. Necrotizing fasciitis in patients on HD requires early diagnosis and aggressive treatment to ensure the favorable clinical outcomes. (Source: Hemodialysis International)
Source: Hemodialysis International - February 3, 2012 Category: Hematology Authors: Chung‐Te LiuYen‐Cheng ChenTso‐Hsiao ChenTsong‐Yih Ou Tags: Case Report Source Type: research
Abiraterone for Prostate Cancer Gets a 'No' in the UKAbiraterone for Prostate Cancer Gets a 'No' in the UKEmail this article to a colleague.
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The news has sparked outrage because the drug was developed in the United Kingdom in research funded by public donations. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 2, 2012 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news
Most Common Tx for Prostate Ca Not Best ValueEmail this article to a colleague.
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SAN FRANCISCO (MedPage Today) -- External beam radiation is the most toxic and expensive among common prostate cancer treatments over the long-term, a national registry study suggested. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - February 2, 2012 Category: Hematology Source Type: news
Drug Shortages Are Speeding Cancer Deaths, Survey SaysDrug Shortages Are Speeding Cancer Deaths, Survey SaysEmail this article to a colleague.
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A survey of American oncologists indicates that drug shortages are not a benign commercial problem. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 2, 2012 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Proton Beam No Better than IMRT for Prostate Cancer (CME/CE)Email this article to a colleague.
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SAN FRANCISCO (MedPage Today) -- For localized prostate cancer, proton beam radiation offers no advantage in minimizing recurrences or side effects, study results suggested. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - February 2, 2012 Category: Hematology Source Type: news
Workouts Shape Up Genes, Prognosis in Prostate Ca (with audio)Email this article to a colleague.
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SAN FRANCISCO (MedPage Today) -- Regular vigorous exercise tones down tumor promoter genes and up regulates tumor suppressor genes for men with prostate cancer, researchers found. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - February 2, 2012 Category: Hematology Source Type: news
Efforts to Reduce Stroke in Kids With Sickle Cell Working: StudyEmail this article to a colleague.
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Ultrasound screening, regular blood transfusions have helped reduce strokes in those with the blood disorder (Source: The Doctors Lounge - Hematology)
Source: The Doctors Lounge - Hematology - February 2, 2012 Category: Hematology Authors: webmaster at doctorslounge.com Tags: Cardiology, Hematology, Neurology, Pediatrics, Research, News, Source Type: news
What is the Evidence for the use of Adrenaline in the Treatment of Neonatal Hypotension?Email this article to a colleague.
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(Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents))
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents) - February 2, 2012 Category: Cardiology Authors: Mahoney, LiamCrook, DavidN Walter, KerstinSherman, EllaRabe, Heike Tags: Articles Source Type: research
30 Years Lost in Anesthesia TheoryEmail this article to a colleague.
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(Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents))
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents) - February 2, 2012 Category: Cardiology Authors: S Coleman, Lewis Tags: Articles Source Type: research
Cardiovascular Aspect of Beta-ThalassaemiaEmail this article to a colleague.
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(Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents))
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents) - February 2, 2012 Category: Cardiology Authors: Taksande, AmarPrabhu, ShakuntalaVenkatesh, Sumitra Tags: Articles Source Type: research
Experience with Multiplex ARMS (MARMS)-PCR for the Detection of Common Thalassemia Mutations in IndiaEmail this article to a colleague.
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(Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents))
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents) - February 2, 2012 Category: Cardiology Authors: Thakur Mahadik, Chitra Tags: Articles Source Type: research
Community Expansion and Gene Geography of Sickle Cell Trait and G6PD Deficiency, and Natural Selection against Malaria: Experience from Tribal Land of IndiaEmail this article to a colleague.
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(Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents))
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents) - February 2, 2012 Category: Cardiology Authors: S Balgir, R. Tags: Articles Source Type: research
Editorial from Guest Editor [ Hot Topic:Current Status of Therapeutics and Preventive Measures for Patients with Thalassaemia and Sickle Cell Disease (Guest Editor: P.H. Reddy)]Email this article to a colleague.
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(Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents))
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular and Hematological Agents) - February 2, 2012 Category: Cardiology Authors: Hemachandra Reddy, P. Tags: Articles Source Type: research
Hyperbaric O2 Helps Most Chronic Radiation Injuries: StudyHyperbaric O2 Helps Most Chronic Radiation Injuries: StudyEmail this article to a colleague.
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Hyperbaric oxygen improves most cases of chronic radiation tissue injury, according to a large single-center report. Reuters Health Information (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - February 2, 2012 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Gemcitabine and docetaxel (GEMDOX) for the treatment of relapsed and refractory pediatric sarcomasEmail this article to a colleague.
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ConclusionsThe dismal outcomes for patients with relapsed and refractory sarcomas and the lack of effective sarcoma salvage regimens highlight the need for new approaches. This report of the therapeutic activity of gemcitabine and docetaxel (GEMDOX) in rhabdomyosarcoma and other pediatric reports describing activity in osteosarcoma and Ewing sarcoma suggest that this combination should be considered for formal evaluation in a pediatric specific clinical trial. At a minimum, it appears to offer a reasonable, tolerable, palliative option. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - February 2, 2012 Category: Cancer & Oncology Authors: Louis RapkinMuna QayedPam BrillMelissa MartinDana ClarkBradley A. GeorgeThomas A. OlsonKaren Wasilewski‐MaskerAdina AlazrakiHoward M. Katzenstein Tags: Research Article Source Type: research
Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessmentEmail this article to a colleague.
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Benzene causes acute myeloid leukemia and probably other hematological malignancies. As benzene also causes hematotoxicity even in workers exposed to levels below the US permissible occupational exposure limit of 1 part per million, further assessment of the health risks associated with its exposure, particularly at low levels, is needed. Here, we describe the probable mechanism by which benzene induces leukemia involving the targeting of critical genes and pathways through the induction of genetic, chromosomal or epigenetic abnormalities and genomic instability, in a hematopoietic stem cell (HSC); stromal cell dysregulati...
Source: Carcinogenesis - February 2, 2012 Category: Cancer & Oncology Authors: McHale, C. M., Zhang, L., Smith, M. T. Tags: REVIEWS Source Type: research
Mechanisms of Alloimmunization and Subsequent Bone Marrow Transplantation Rejection Induced by Platelet Transfusion in a Murine ModelEmail this article to a colleague.
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For many nonmalignant hematological disorders, HLA‐matched bone marrow transplantation (BMT) is curative. However, due to lack of neoplasia, the toxicity of stringent conditioning regimens is difficult to justify, and reduced intensity conditioning is used. Unfortunately, current reduced intensity regimens have high rates of BMT rejection. We have recently reported in a murine model that mHAs on transfused platelet products induce subsequent BMT rejection. Most nonmalignant hematological disorders require transfusion support prior to BMT and the rate of BMT rejection in humans correlates with the number of transfusions g...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: S. R. PatelN. H. SmithL. KappJ. C. Zimring Source Type: research
Deregulation of apoptosis-related genes is associated with PRV1 overexpression and JAK2 V617F allele burden in Essential Thrombocythemia and MyelofibrosisEmail this article to a colleague.
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Conclusions:
Our results suggest the participation of intrinsic apoptosis pathway in the MPN physiopathology. In addition, PRV1 and JAK2 V617F allele burden were linked to deregulation of the apoptotic machinery. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - February 2, 2012 Category: Hematology Authors: Raquel TognonElainy GasparottoRenata NevesNatalia NunesAline FerreiraPatricia PalmaSimone KashimaDimas CovasMary SantanaElizabeth SoutoMaria Aparecida ZanichelliBelinda SimoesAna Maria SouzaFabiola Castro Source Type: research
Current status of additive solutions for plateletsEmail this article to a colleague.
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AbstractThe storage of platelets in additive solution (PAS) had lagged behind red cell concentrates, especially in North America. The partial or complete removal of anticoagulated plasma and storage of platelet concentrates in AS presents many advantages. The PAS can be formulated to optimize aerobic metabolism or decrease platelet activation, thus abrogating the platelet storage lesion and potentially improving in vivo viability. Plasma removal has been shown to reduce allergic reactions and the plasma harvested could contribute to the available plasma pool for transfusion or fractionation. PAS coupled to pathogen reducti...
Source: Journal of Clinical Apheresis - February 2, 2012 Category: Hematology Authors: Hiba AlhumaidanJoseph Sweeney Tags: Brief Report Source Type: research
The effective use of plerixafor as a real‐time rescue strategy for patients poorly mobilizing autologous CD34+ cellsEmail this article to a colleague.
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AbstractPlerixafor enhances CD34+ cell mobilization, however, its optimal use is unknown. We hypothesized that plerixafor could “rescue” patients in the midst of mobilization when factors indicated a poor CD34+ yield. Of 295 consecutive autologous peripheral blood mobilization attempts at our center, 39 (13%) used plerixafor as rescue strategy due to a CD34+ cell concentration <10/μl (median 5.95/μl, n = 30), low CD34+ cell yield from prior apheresis day (median 1.06 × 106 CD34+ cells/kg, n = 7), or other (n = 2). Patients received a median of one plerixafor dose (range: 1–4). Thirty‐four (87%) collected =2 ...
Source: Journal of Clinical Apheresis - February 2, 2012 Category: Hematology Authors: Ajay K. GopalMehdi KaramiJoAl MayorMylene MacebeoMichael LinenbergerWilliam I. BensingerLeona Holmberg Tags: Research Article Source Type: research
Predictive factors for inadequate stem cell mobilization in Chinese patients with NHL and HL: 14‐year experience of a single‐center studyEmail this article to a colleague.
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Conclusion: Our analysis showed that high amounts of chemotherapy, radiotherapy, low platelet count, chemosensitive recurrent patients, combination chemotherapy plus G‐CSF and low CD34+ cells in BM prior to mobilization could emerged as important predictive factors for mobilization failure in Chinese patients with NHL and HL. J. Clin. Apheresis, 2012. © 2012 Wiley Periodicals, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - February 2, 2012 Category: Hematology Authors: Xiaohong HanLi MaLingdi ZhaoXiaohui HePeng LiuShengyu ZhouJianliang YangYan QinSheng YangJiarui YaoYuankai Shi Tags: Research Article Source Type: research
Doubts concerning functional endothelial nitric oxide synthase in human erythrocytesEmail this article to a colleague.
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(Source: Blood)
Source: Blood - February 2, 2012 Category: Hematology Authors: Bohmer, A., Beckmann, B., Sandmann, J., Tsikas, D. Tags: CORRESPONDENCE Source Type: research
Response: BH3 mimetics modulate calcium homeostasis in plateletsEmail this article to a colleague.
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(Source: Blood)
Source: Blood - February 2, 2012 Category: Hematology Authors: Vogler, M., Goodall, A. H., Cohen, G. M. Tags: CORRESPONDENCE Source Type: research
Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet functionEmail this article to a colleague.
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(Source: Blood)
Source: Blood - February 2, 2012 Category: Hematology Authors: Schoenwaelder, S. M., Jackson, S. P. Tags: CORRESPONDENCE Source Type: research
Genetic defects in PRC2 components other than EZH2 are not common in myeloid malignanciesEmail this article to a colleague.
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(Source: Blood)
Source: Blood - February 2, 2012 Category: Hematology Authors: Kroeze, L. I., Nikoloski, G., da Silva-Coelho, P., van Hoogen, P., Stevens-Linders, E., Kuiper, R. P., Schnittger, S., Haferlach, T., Pahl, H. L., van der Reijden, B. A., Jansen, J. H. Tags: CORRESPONDENCE Source Type: research
Macrophages have no lineage history of Foxp3 expressionEmail this article to a colleague.
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(Source: Blood)
Source: Blood - February 2, 2012 Category: Hematology Authors: Put, S., Avau, A., Humblet-Baron, S., Schurgers, E., Liston, A., Matthys, P. Tags: CORRESPONDENCE Source Type: research
Lack of Foxp3+ macrophages in both untreated and B16 melanoma-bearing miceEmail this article to a colleague.
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(Source: Blood)
Source: Blood - February 2, 2012 Category: Hematology Authors: Mayer, C. T., Kuhl, A. A., Loddenkemper, C., Sparwasser, T. Tags: CORRESPONDENCE Source Type: research
The recombinant lectin-like domain of thrombomodulin inhibits angiogenesis through interaction with Lewis Y antigenEmail this article to a colleague.
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Lewis Y Ag (LeY) is a cell-surface tetrasaccharide that participates in angiogenesis. Recently, we demonstrated that LeY is a specific ligand of the recombinant lectin-like domain of thrombomodulin (TM). However, the biologic function of interaction between LeY and TM in endothelial cells has never been investigated. Therefore, the role of LeY in tube formation and the role of the recombinant lectin-like domain of TM—TM domain 1 (rTMD1)—in antiangiogenesis were investigated. The recombinant TM ectodomain exhibited lower angiogenic activity than did the recombinant TM domains 2 and 3. rTMD1 interacted with solub...
Source: Blood - February 2, 2012 Category: Hematology Authors: Kuo, C.-H., Chen, P.-K., Chang, B.-I., Sung, M.-C., Shi, C.-S., Lee, J.-S., Chang, C.-F., Shi, G.-Y., Wu, H.-L. Tags: Vascular Biology Source Type: research
GSK-3{beta} regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1{alpha}Email this article to a colleague.
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We report a novel mechanism by which HIF-1α is degraded after glycogen synthase kinase-3 (GSK-3)–induced phosphorylation and recruitment of the ubiquitin ligase and tumor suppressor F-box and WD protein Fbw7. Further, experiments with GSK-3β and Fbw7-deficient cells revealed that GSK-3β and Fbw7-dependent HIF-1α degradation can be antagonized by ubiquitin-specific protease 28 (USP28). In agreement with this, Fbw7 and USP28 reciprocally regulated cell migration and angiogenesis in an HIF-1α–dependent manner. Therefore, we have identified a new pathway that could be targeted at the lev...
Source: Blood - February 2, 2012 Category: Hematology Authors: Flugel, D., Gorlach, A., Kietzmann, T. Tags: Vascular Biology Source Type: research
Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculatureEmail this article to a colleague.
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Recent work has established that heterozygous germline GATA2 mutations predispose carriers to familial myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML), "MonoMAC" syndrome, and DCML deficiency. Here, we describe a previously unreported MDS family carrying a missense GATA2 mutation (p.Thr354Met), one patient with MDS/AML carrying a frameshift GATA2 mutation (p.Leu332Thrfs*53), another with MDS harboring a GATA2 splice site mutation, and 3 patients exhibiting MDS or MDS/AML who have large deletions encompassing the GATA2 locus. Intriguingly, 2 MDS/AML or "MonoMAC" syndrome patients with GATA2 deletions and one wit...
Source: Blood - February 2, 2012 Category: Hematology Authors: Kazenwadel, J., Secker, G. A., Liu, Y. J., Rosenfeld, J. A., Wildin, R. S., Cuellar-Rodriguez, J., Hsu, A. P., Dyack, S., Fernandez, C. V., Chong, C.-E., Babic, M., Bardy, P. G., Shimamura, A., Zhang, M. Y., Walsh, T., Holland, S. M., Hickstein, D. D., Ho Tags: Myeloid Neoplasia, Vascular Biology Source Type: research
Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cellsEmail this article to a colleague.
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Histone methylation is thought to be important for regulating Ag-driven T-cell responses. However, little is known about the effect of modulating histone methylation on inflammatory T-cell responses. We demonstrate that in vivo administration of the histone methylation inhibitor 3-deazaneplanocin A (DZNep) arrests ongoing GVHD in mice after allogeneic BM transplantation. DZNep caused selective apoptosis in alloantigen-activated T cells mediating host tissue injury. This effect was associated with the ability of DZNep to selectively reduce trimethylation of histone H3 lysine 27, deplete the histone methyltransferase Ezh2 sp...
Source: Blood - February 2, 2012 Category: Hematology Authors: He, S., Wang, J., Kato, K., Xie, F., Varambally, S., Mineishi, S., Kuick, R., Mochizuki, K., Liu, Y., Nieves, E., Mani, R.-S., Chinnaiyan, A. M., Marquez, V. E., Zhang, Y. Tags: Transplantation Source Type: research
Desialylation accelerates platelet clearance after refrigeration and initiates GPIb{alpha} metalloproteinase-mediated cleavage in miceEmail this article to a colleague.
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When refrigerated platelets are rewarmed, they secrete active sialidases, including the lysosomal sialidase Neu1, and express surface Neu3 that remove sialic acid from platelet von Willebrand factor receptor (VWFR), specifically the GPIbα subunit. The recovery and circulation of refrigerated platelets is greatly improved by storage in the presence of inhibitors of sialidases. Desialylated VWFR is also a target for metalloproteinases (MPs), because GPIbα and GPV are cleaved from the surface of refrigerated platelets. Receptor shedding is inhibited by the MP inhibitor GM6001 and does not occur in Adam17Zn/Zn plat...
Source: Blood - February 2, 2012 Category: Hematology Authors: Jansen, A. J. G., Josefsson, E. C., Rumjantseva, V., Liu, Q. P., Falet, H., Bergmeier, W., Cifuni, S. M., Sackstein, R., von Andrian, U. H., Wagner, D. D., Hartwig, J. H., Hoffmeister, K. M. Tags: Transfusion Medicine, Platelets and Thrombopoiesis Source Type: research
TFPI{beta} is the GPI-anchored TFPI isoform on human endothelial cells and placental microsomesEmail this article to a colleague.
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Tissue factor pathway inhibitor (TFPI) produces factor Xa-dependent feedback inhibition of factor VIIa/tissue factor-induced coagulation. Messages for 2 isoforms of TFPI have been identified. TFPIα mRNA encodes a protein with an acidic N-terminus, 3 Kunitz-type protease inhibitor domains and a basic C-terminus that has been purified from plasma and culture media. TFPIβ mRNA encodes a form in which the Kunitz-3 and C-terminal domains of TFPIα are replaced with an alternative C-terminus that directs the attachment of a glycosylphosphatidylinositol (GPI) anchor, but whether TFPIβ protein is actually expr...
Source: Blood - February 2, 2012 Category: Hematology Authors: Girard, T. J., Tuley, E., Broze, G. J. Tags: Thrombosis and Hemostasis, Vascular Biology Source Type: research
Heparin-induced thrombocytopenia: in vitro studies on the interaction of dabigatran, rivaroxaban, and low-sulfated heparin, with platelet factor 4 and anti-PF4/heparin antibodiesEmail this article to a colleague.
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Heparin is a widely used anticoagulant. Because of its negative charge, it forms complexes with positively charged platelet factor 4 (PF4). This can induce anti-PF4/heparin IgG Abs. Resulting immune complexes activate platelets, leading to the prothrombotic adverse drug reaction heparin-induced thrombocytopenia (HIT). HIT requires treatment with alternative anticoagulants. Approved for HIT are 2 direct thrombin inhibitors (DTI; lepirudin, argatroban) and danaparoid. They are niche products with limitations. We assessed the effects of the DTI dabigatran, the direct factor Xa-inhibitor rivaroxaban, and of 2-O, 3-O desulfated...
Source: Blood - February 2, 2012 Category: Hematology Authors: Krauel, K., Hackbarth, C., Furll, B., Greinacher, A. Tags: Thrombosis and Hemostasis Source Type: research
Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabineEmail this article to a colleague.
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The deoxycytidine analog decitabine (DAC) can deplete DNA methyl-transferase 1 (DNMT1) and thereby modify cellular epigenetics, gene expression, and differentiation. However, a barrier to efficacious and accessible DNMT1-targeted therapy is cytidine deaminase, an enzyme highly expressed in the intestine and liver that rapidly metabolizes DAC into inactive uridine counterparts, severely limiting exposure time and oral bioavailability. In the present study, the effects of tetrahydrouridine (THU), a competitive inhibitor of cytidine deaminase, on the pharmacokinetics and pharmacodynamics of oral DAC were evaluated in mice and...
Source: Blood - February 2, 2012 Category: Hematology Authors: Lavelle, D., Vaitkus, K., Ling, Y., Ruiz, M. A., Mahfouz, R., Ng, K. P., Negrotto, S., Smith, N., Terse, P., Engelke, K. J., Covey, J., Chan, K. K., DeSimone, J., Saunthararajah, Y. Tags: Red Cells, Iron, and Erythropoiesis Source Type: research
Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathwaysEmail this article to a colleague.
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Survival signaling by the erythropoietin (Epo) receptor (EpoR) is essential for erythropoiesis and for its acceleration in hypoxic stress. Several apparently redundant EpoR survival pathways were identified in vitro, raising the possibility of their functional specialization in vivo. Here we used mouse models of acute and chronic stress, including a hypoxic environment and β-thalassemia, to identify two markedly different response dynamics for two erythroblast survival pathways in vivo. Induction of the antiapoptotic protein Bcl-xL is rapid but transient, while suppression of the proapoptotic protein Bim is slower but...
Source: Blood - February 2, 2012 Category: Hematology Authors: Koulnis, M., Porpiglia, E., Porpiglia, P. A., Liu, Y., Hallstrom, K., Hidalgo, D., Socolovsky, M. Tags: Red Cells, Iron, and Erythropoiesis Source Type: research
Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endotheliumEmail this article to a colleague.
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The core pathology of sickle cell disease (SCD) starts with the erythrocyte (RBC). Aberration in MAPK/ERK1/2 signaling, which can regulate cell adhesion, occurs in diverse pathologies. Because RBCs contain abundant ERK1/2, we predicted that ERK1/2 is functional in sickle (SS) RBCs and promotes adherence, a hallmark of SCD. ERK1/2 remained active in SS but not normal RBCs. β2-adrenergic receptor stimulation by epinephrine can enhance ERK1/2 activity only in SS RBCs via PKA- and tyrosine kinase p72syk-dependent pathways. ERK signaling is implicated in RBC ICAM-4 phosphorylation, promoting SS RBC adhesion to the endothel...
Source: Blood - February 2, 2012 Category: Hematology Authors: Zennadi, R., Whalen, E. J., Soderblom, E. J., Alexander, S. C., Thompson, J. W., Dubois, L. G., Moseley, M. A., Telen, M. J. Tags: Red Cells, Iron, and Erythropoiesis Source Type: research
