Treatment of septic patients with an arginine-based endotoxin adsorber column improves hemodynamics and reduces oxidative stress: results of a feasibility study
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Blood Purif 2008;26:333-339 (DOI:10.1159/000132464) (Source: Blood Purification)
Source: Blood Purification - May 17, 2008 Category: Hematology Source Type: journals
Strong association between nutritional markers and arterial stiffness in continuous ambulatory peritoneal dialysis patients
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Blood Purif 2008;26:340-346 (DOI:10.1159/000132465) (Source: Blood Purification)
Source: Blood Purification - May 17, 2008 Category: Hematology Source Type: journals
Double-filtration plasmapheresis in the treatment of leg ulcers in cryoglobulinemia
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We describe a case of HCV-positive type I cryoglobulinemia with severe leg ulcers, not responsive to antiviral and immunosuppressive treatment. Thirty sessions of double filtration plasmapheresis were performed, over a period of 6 months, with no other associated treatment. Before and after each session an assessment of immunoglobulins, complement, cryocrit, and fibrinogen was made. HCV RNA levels were determined in serum cryoprecipitate, supernatant before and after each session, and in the collection bag. No differences in pre and postapheresis values were observed in the serum concentrations and the supernatant, whereas...
Source: Journal of Clinical Apheresis - May 17, 2008 Category: Hematology Authors: A. Ramunni, G. Lauletta, P. Brescia, M.T. Saliani, M. Montrone, M. Chironna, D. Sansonno, F. Dammacco, P. Coratelli Source Type: journals
Asco: mtor inhibitor delays progression of metastatic renal cell carcinoma
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NEW YORK -- More than 60% of metastatic kidney cancer patients taking an investigational mTOR inhibitor had a delay in progression of their disease, researchers here said. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - May 16, 2008 Category: Hematology Source Type: info
Missing mutations hold clue to imatinib (gleevec) gist resistance
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PHILADELPHIA -- Some patients with gastrointestinal stromal tumors (GIST) who are imatinib (Gleevec)-resistant don't respond because they are missing the mutations in two genes that are usually integral to the illness. Now researchers here have found out what may be causing their disease. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - May 16, 2008 Category: Hematology Source Type: info
Ons: cancer fatigue is more than just feeling tired
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PHILADELPHIA -- Fatigue associated with cancer radiotherapy is more complex than is generally recognized and should be thoroughly explored in patients reporting fatigue symptoms, a researcher said here. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - May 16, 2008 Category: Hematology Source Type: info
Anaemia and cigarette smoking.
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This article presents an evaluation of the current literature on the impact of cigarette smoking on various forms of anaemia.
PMID: 18479294 [PubMed - in process] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 16, 2008 Category: Hematology Authors: Leifert JA Tags: Int J Lab Hematol Source Type: journals
Conjugation of methotrexate to immunoglobulins kills macrophages by f(c) receptor mediated uptake?
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Conjugation of methotrexate to immunoglobulins kills macrophages by F(c) receptor mediated uptake?
Int J Lab Hematol. 2008 Jun;30(3):185-90
Authors: Wang X, Yao C, Jiang Z
The aim of this study was to conjugate methotrexate (MTX) with intravenous immunoglobulin (IVIG) and investigate whether the conjugate produce selective cytotoxicity on macrophages to provide a new strategy for the management of idiopathic thrombocytopenic purpura. MTX was bound to IVIG via human serum albumin as an intermediary. The binding activity of the F(c) fragment of the conjugate was assayed by flow cytometry. The selective cytotoxici...
Source: International Journal of Laboratory Hematology - May 16, 2008 Category: Hematology Authors: Wang X, Yao C, Jiang Z Tags: Int J Lab Hematol Source Type: journals
Delayed decline of gamma-globin expression in infant age associated with the presence of (g)gamma-158 (c-->t) polymorphism.
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Delayed decline of gamma-globin expression in infant age associated with the presence of (G)gamma-158 (C-->T) polymorphism.
Int J Lab Hematol. 2008 Jun;30(3):191-195
Authors: Grosso M, Amendolara M, Rescigno G, Danise P, Todisco N, Izzo P, Amendola G
Persistent production of fetal hemoglobin (HbF) in adult has ameliorative effects on hemoglobinopathies and great efforts are currently made to achieve an exhaustive understanding of the molecular mechanisms of the switching in globin gene expression. One of the factors reported to be associated with the expression of fetal globin genes is the Xmn I (G)gamma-158...
Source: International Journal of Laboratory Hematology - May 16, 2008 Category: Hematology Authors: Grosso M, Amendolara M, Rescigno G, Danise P, Todisco N, Izzo P, Amendola G Tags: Int J Lab Hematol Source Type: journals
Bio-maleimide as a generic stain for detection and quantitation of microparticles.
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Microparticles (MP) are small fragments of cytoplasm shed from a cell surface and their role in the pathophysiology of disease is being extensively investigated. A novel staining technique for quantifying total MP in peripheral blood was evaluated in this study. Evaluation of Bodipy-maleimide (or bio-maleimide) as a stain for quantifying total MP in peripheral blood by flow cytometry. Samples were obtained from 10 healthy donors after informed consent. Plasma was prepared by sequential centrifugation at 1500 g followed by 13 000 g and stained with Annexin V and bio-maleimide. Enumeration beads were added after 15 min o...
Source: International Journal of Laboratory Hematology - May 16, 2008 Category: Hematology Authors: Enjeti AK, Lincz L, Seldon M Tags: Int J Lab Hematol Source Type: journals
Comparison of an immuno-turbidometric method (stalia((r))d-di) with an established enzyme linked fluorescent assay (vidas((r))) d-dimer for the exclusion of venous thromboembolism.
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In conclusion, 88% (88/100) of patients showed agreement and in the other 12% (12/100), one had a DVT as identified by Compression ultrasonography (CUS). In this study, there were seven patients with a DVT as identified by CUS and they all scored as 'likely' on a pretest clinical probability score and so negative d-dimer would not be used clinically to rule out the disease. The Vidas is a well established instrument for d-dimer measurement in outpatient DVT clinics, and in this small study the STalia((R)) compares very well and therefore would fit into an outpatient setting for d-dimer measurement. But ideally a larger stu...
Source: International Journal of Laboratory Hematology - May 16, 2008 Category: Hematology Authors: Sukhu K, Beavis J, Baker PM, Keeling DM Tags: Int J Lab Hematol Source Type: journals
Performance evaluation of bc-3200 hematology analyzer in a university hospital.
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Performance evaluation of BC-3200 hematology analyzer in a university hospital.
Int J Lab Hematol. 2008 Jun;30(3):205-13
Authors: Peng L, Bai L, Nie L, Wu Z, Yan C
The BC-3200 automated hematology analyzer was evaluated and compared with the Beckman-Coulter AcT (A(c).T diff 2) 3-part differential hematology analyzer. The BC-3200 was evaluated according to guidelines published by the International Committee for Standardization in Hematology (ICSH), Clinical and Laboratory Standards Institute (CLSI), and Department of Food and Drug Administration (FDA). The results demonstrated no background, minimal carryover (&...
Source: International Journal of Laboratory Hematology - May 16, 2008 Category: Hematology Authors: Peng L, Bai L, Nie L, Wu Z, Yan C Tags: Int J Lab Hematol Source Type: journals
Platelet size has diagnostic predictive value for bone marrow metastasis in patients with solid tumors.
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Though not very common, solid tumor involvement of the bone marrow (BM) may have serious consequences. Recent studies have shown that mean platelet volume (MPV) is a good indicator for BM disease in the differential diagnosis of thrombocytopenia. We investigated the significance of MPV in the diagnosis of BM metastasis in patients with solid tumors. Patients with histologically-verified solid tumors for whom BM biopsy specimens were available (n = 121) and healthy controls (n = 62) were included in this retrospective study. A total of 183 individuals were analyzed. Of the patients, 61 had a diagnosis of BM metastasis (...
Source: International Journal of Laboratory Hematology - May 16, 2008 Category: Hematology Authors: Aksoy S, Kilickap S, Hayran M, Harputluoglu H, Koca E, Dede DS, Erman M, Turker A Tags: Int J Lab Hematol Source Type: journals
The effects of thalidomide on chemotactic migration of multiple myeloma cell lines.
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We examined the effect of thalidomide and dexamethasone on the migration of multiple myeloma (MM) cell lines, U266, RPMI8226, and NCI-H929, using chemotaxis chamber plates. U266 underwent chemotactic migration in response to stromal-cell derived factor-1 alpha (SDF-1alpha), and other cell lines underwent random migration in response to SDF-1alpha or monocyte chemotactic protein-1 alpha. Following preincubation with 1 mug/ml thalidomide, the cell lines showed reduced migratory capacity in response to SDF-1alpha. Concerning the corresponding receptors, CXC chemokine receptor 4 was detected only on the surface of U266, by flo...
Source: International Journal of Laboratory Hematology - May 16, 2008 Category: Hematology Authors: Fuchida SI, Shimazaki C, Hirai H, Akamatsu S, Yamada N, Uchida R, Okano A, Okamoto M, Inaba T, Taniwaki M Tags: Int J Lab Hematol Source Type: journals
Correlation of serum il-6, il-8 and il-10 levels with clinicopathological features and prognosis in patients with diffuse large b-cell lymphoma.
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This study aimed to determine the relationship(s) between serum levels of interleukin (IL)-6, IL-8 and IL-10, measured by enzyme-immunoassay, and the clinical characteristics and outcomes in 46 untreated patients with diffuse large B-cell lymphoma (DLBCL). Serum IL-6, IL-8 and IL-10 levels were higher in DLBCL patients than in control subjects. Elevated levels of IL-6, IL-8 and IL-10 correlated with more adverse disease features. Consequently, patients with elevated IL-6, IL-8 and IL-10 levels prior to treatment had a lower response to therapy. Furthermore, those with elevated IL-6 and IL-10 levels had poor median, 3-year ...
Source: International Journal of Laboratory Hematology - May 16, 2008 Category: Hematology Authors: Nacinović-Duletić A, Stifter S, Dvornik S, Skunca Z, Jonjić N Tags: Int J Lab Hematol Source Type: journals
Single nucleotide polymorphisms in the apo(a) kringle iv type 8 domain are not associated with atherothrombotic serum lipoprotein (a) concentration, in a portuguese paediatric population.
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Single nucleotide polymorphisms in the apo(a) kringle IV type 8 domain are not associated with atherothrombotic serum lipoprotein (a) concentration, in a portuguese paediatric population.
Int J Lab Hematol. 2008 Jun;30(3):240-3
Authors: Ferreira H, Costa E, Vieira E, Barbot J, Dos Santos R
Lipoprotein (a) (Lp[a]) is a complex of apolipoprotein (a) (apo[a]) and low-density lipoprotein (LDL), associated with atherothrombotic disease. Most of the interindividual variations in plasma levels of Lp(a) can be attributed to sequence differences linked to the apo(a) gene locus. The aim of this study was to investigate a...
Source: International Journal of Laboratory Hematology - May 16, 2008 Category: Hematology Authors: Ferreira H, Costa E, Vieira E, Barbot J, Dos Santos R Tags: Int J Lab Hematol Source Type: journals
A case of paroxysmal nocturnal hemoglobinuria presenting with intra-abdominal bleeding due to splenic rupture, developing renal infarct.
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This report describes an atypical clinical presentation with problems in the diagnosis and management of a woman who presented with a splenic infarct followed by massive intra-abdominal bleeding due to splenic rupture. She also developed a renal infarct during hospitalization after diagnosis.
PMID: 18479304 [PubMed - in process] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 16, 2008 Category: Hematology Authors: Uzun S, Alpay N, Ozturk GB, Saka B, Yenerel M, Erten N, Karan MA, Taşcioglu C Tags: Int J Lab Hematol Source Type: journals
Evaluation of morpho/immunological telehaematology file exchanges for the inclusion of patients with chronic lymphocytic leukaemia in a therapeutic trial.
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PMID: 18479305 [PubMed - in process] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 16, 2008 Category: Hematology Authors: Lesesve J, Palmiéri A, Brion A, Feugier P, Mahé B, Garand R Tags: Int J Lab Hematol Source Type: journals
Expression of zap-70 in patients with chronic lymphocytic leukemia may change significantly during the course of the disease.
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Expression of ZAP-70 in patients with chronic lymphocytic leukemia may change significantly during the course of the disease.
Int J Lab Hematol. 2008 Jun;30(3):259-60
Authors: Smolej L, Vroblova V, Novosad J
PMID: 18479306 [PubMed - in process] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 16, 2008 Category: Hematology Authors: Smolej L, Vroblova V, Novosad J Tags: Int J Lab Hematol Source Type: journals
New hope for uk follicular lymphoma patients as zevalin(r), [90y]-ibritumomab tiuxetan, licenced for first line consolidation therapy
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Zevalin ([90Y]-ibritumomab tiuxetan) can now be used as first-line consolidation therapy after remission induction in previously untreated patients with follicular lymphoma (FL). (Source: Lymphoma / Leukemia News From Medical News Today)
Source: Lymphoma / Leukemia News From Medical News Today - May 16, 2008 Category: Hematology Source Type: news
Effects of rosiglitazone on contralateral iliac artery after vascular injury in hypercholesterolemic rabbits.
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Conclusions: These findings demonstrate that rosiglitazone given for 6 weeks did not prevent atherogenesis at a vessel distant from the injury site. (Source: Thrombosis Journal)
Source: Thrombosis Journal - May 16, 2008 Category: Hematology Authors: Olimpio RIBEIRO Franca, Dalton BERTOLIM Precoma, Alexandre Alessi, Camila Prim, Ruy FERNANDO KUENZER CAETANO Silva, Lucia Noronha and Liz ANDREA VILLELA Baroncini Source Type: journals
Pleural mesothelioma trial shows no benefit for chemo
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LONDON, May 15 -- Adding chemotherapy to active symptom control in cases of malignant pleural mesothelioma appeared to have little effect in a large randomized trial, researchers here said. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - May 15, 2008 Category: Hematology Source Type: info
A single-nucleotide polymorphism in the human itgb3 gene is associated with the platelet-specific alloantigen vaa (hpa-17bw) involved in fetal maternal alloimmune thrombocytopenia
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Transfusion, Volume 0, Issue 0, Page ???, OnlineEarly Articles.
BACKGROUND: The previously reported platelet (PLT)-specific antigen, Vaa, was defined by an alloantibody detected in the serum sample of a mother who delivered an infant displaying symptoms of severe fetal maternal alloimmune thrombocytopenia (FMAIT). ... (Source: Transfusion)
Source: Transfusion - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Fibrinogen gene variation and ischemic stroke
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 897-904, June 2008.
Summary. Background: Plasma fibrinogen level and fibrin clot structure are heritable traits that may be of importance in the pathogenesis of ischemic stroke. Objectives: To investigate associations between variation in the fibrinogen gamma (FGG), alpha (... (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Prevalence and significance of vitamin d deficiency in multiple myeloma patients
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British Journal of Haematology, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: British Journal of Haematology)
Source: British Journal of Haematology - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Protein c supports platelet binding and activation under flow: role of glycoprotein ib and apolipoprotein e receptor 2
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 995-1002, June 2008.
Summary. Background: Activated protein C (APC) regulates thrombin generation and inhibits apoptosis. Endothelial protein C receptor (EPCR)-bound protein C is activated by thrombomodulin-bound thrombin. APC inactivates coagulation factors (F)Va/VIIIa and ... (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
A contribution to the debate on the laboratory criteria that define the antiphospholipid syndrome
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1048-1049, June 2008. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Tissue factor and il8 production by p-selectin-dependent platelet–monocyte aggregates in whole blood involves phosphorylation of lyn and is inhibited by il10
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 986-994, June 2008.
Summary. Background: P-selectin and CD40L expressed by activated platelets induce tissue factor (TF) and inflammatory cytokines in monocytes, but little is known of the cellular signaling pathways involved. The anti-inflammatory cytokine IL10 reduces ... (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Join isth
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1057, June 2008. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Cytoprotective effect of activated protein c: specificity of par-1 signaling
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 951-953, June 2008. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Ante- and postnatal risk factors of venous thrombosis: a hospital-based case–control study
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 905-912, June 2008.
Summary. Objective: To study ante- and postnatal risk factors of venous thrombosis (VT) in pregnancy. Methods: A hospital-based case–control study. Cases were women with objectively verified VT during pregnancy or postpartum. Two controls were selected ... (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Protease activated receptor 1 activation of platelet is associated with an increase in protein kinase ck2 activity
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1046-1048, June 2008. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Circulating endothelial cells in health and disease: how do we best quantify them?
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1021-1024, June 2008. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Ex vivo inhibition of thrombus formation by an anti-glycoprotein vi fab fragment in non-human primates without modification of glycoprotein vi expression
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1003-1011, June 2008.
Summary. Objectives: Glycoprotein (GP)VI is an attractive target for the development of new antithrombotic drugs. Its deficiency protects animals in several models of thrombosis, arterial stenosis and ischemia-–reperfusion while inducing no major bleeding ... (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Hemostatic effect of recombinant factor viia, nn1731 and recombinant factor viii on needle-induced joint bleeding in hemophilia a mice
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 969-975, June 2008.
Summary. Background: Hemophilia A is the most common serious bleeding disorder, and the hallmark of this disease is joint bleeding episodes. These result in hemophilic synovitis, an inflammatory and proliferative condition of the joint, which progresses ... (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
The src requirement for washed platelet aggregation and dense granule secretion in response to stimulation by a low level γ-thrombin
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1035-1037, June 2008. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Lower factor xii activity is a risk marker rather than a risk factor for cardiovascular disease: a rebuttal
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1053-1054, June 2008. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Continuation of the international standard thromboplastin (human, recombinant, plain) by means of a replacement reconstitution fluid
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1042-1043, June 2008. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Protein s enhances the tissue factor pathway inhibitor inhibition of factor xa but not its inhibition of factor viia–tissue factor
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1044-1046, June 2008. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
The importance of anticoagulant agents in measuring platelet aggregation in patients treated with clopidogrel and aspirin
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1040-1042, June 2008. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
An international multicenter randomized study of computer-assisted oral anticoagulant dosage vs. medical staff dosage
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 935-943, June 2008.
Summary. Background: Increased demand for oral anticoagulants is overwhelming facilities worldwide, resulting in increasing use of computer assistance. A multicenter clinical endpoint study has been performed to compare the safety and effectiveness of ... (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Microparticle-mediated thrombin generation assay: increased activity in patients with recurrent thrombosis
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 913-919, June 2008.
Summary. Background: Circulating cell-derived microparticles (MP) are important players in thrombogenesis, attributed in part to tissue factor (TF) carried on them. We developed MP-mediated thrombin generation assay (TGA) and measured a series of patients ... (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
A first-in-human phase i trial of locally delivered human plasmin for hemodialysis graft occlusion
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 944-950, June 2008.
Summary. Background: Hemodialysis (HD) grafts often fail because of stenosis at the venous anastomosis and thrombotic occlusion. Percutaneous management relies on thrombolysis with plasminogen activators, mechanical removal of thrombus, and angioplasty of ... (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Differential impact of conventional-dose and low-dose postmenopausal hormone therapy, tibolone and raloxifene on c-reactive protein and other inflammatory markers
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 928-934, June 2008.
Summary. Background: Postmenopausal hormone therapy (HT) is associated with an increased risk for arterial and venous thrombosis. Objectives: To compare the impact of HT, tibolone, and raloxifene on C-reactive protein (CRP) and other inflammatory markers, ... (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Non-invasive viral gene transfer of factor ix to colonic epithelial cells in hemophilia b mice
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1033-1035, June 2008. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Lipid raft localization regulates the cleavage specificity of protease activated receptor 1 in endothelial cells
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 954-961, June 2008.
Summary. Background: The endothelial protein C receptor (EPCR)-dependent cleavage of protease activated receptor 1 (PAR-1) by either activated protein C (APC) or thrombin in lipid rafts initiates protective signaling responses in endothelial cells. ... (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: an in vitro study
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 962-968, June 2008.
Summary. Background: Human prothrombin complex concentrates (PCCs) are used for prevention and treatment of bleeding episodes in patients under warfarin therapy. PCCs contain human factor (F) II, FVII, FIX, FX, protein C and protein S. The concentrations ... (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Globular adiponectin induces platelet activation through the collagen receptor gpvi-fc receptor γ chain complex
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1012-1020, June 2008.
Summary. Background: The adipocyte-derived cytokine, adiponectin (Ad), exerts potent vascular effects, although the direct effects of Ad on blood platelets are unclear. Objective: The influence of globular Ad (gAd) on blood platelet function was ... (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
P-selectin polymorphisms’ influences on p-selectin serum concentrations and on their familial correlation: the stanislas family study
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 920-927, June 2008.
Summary. Background: P-selectin is an adhesion molecule known to be involved in the pathogenesis of several diseases through its major role in the initial phase of leukocytes recruitment during inflammation. However, genetic characterization of soluble P-... (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
Acquired von willebrand disease: potential contribution of the von willebrand factor collagen-binding to the identification of functionally inhibiting auto-antibodies to von willebrand factor: a rebuttal
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Journal of Thrombosis and Haemostasis, Volume 6, Issue 6, Page 1051-1052, June 2008. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - May 15, 2008 Category: Hematology Tags: article Source Type: journals
