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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 3.

Adrenal haemorrhage due to heparin-induced thrombocytopenia.
In conclusion, AH is an important but seldom recognised presumed thrombotic complication of HIT, which usually occurs in the postoperative period, especially after orthopaedic procedures. This syndrome can occur in the apparent absence of heparin exposure, especially following major joint replacement surgery. PMID: 23389301 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Authors: Ketha S, Smithedajkul P, Vella A, Pruthi R, Wysokinski W, McBane R Tags: Thromb Haemost Source Type: research

Dabigatran elimination: is haemodialysis effective?
PMID: 23389392 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Authors: McLellan AJ, Schlaich MP Tags: Thromb Haemost Source Type: research

Function of eltrombopag-induced platelets compared to platelets from control patients with immune thrombocytopenia.
Abstract Data on the in vivo function of platelets induced by the thrombopoietin receptor agonist eltrombopag are scarce. To assess a possible influence of eltrombopag we compared platelet function of eltrombopag-treated immune thrombocytopenia (ITP) patients (group 1; n=10) after treatment response to that from control ITP patients (group 2; n=12). We further analysed platelet function at baseline and after one, three, and four weeks of eltrombopag treatment and estimated daily changes of platelet function during the eltrombopag-induced platelet rise. The formation of platelet-monocyte aggregates (PMA), P-selectin...
Source: Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Authors: Haselboeck J, Kaider A, Pabinger I, Panzer S Tags: Thromb Haemost Source Type: research

Effective elimination of dabigatran by haemodialysis. A phase I single-centre study in patients with end-stage renal disease.
In conclusion, a 4 hour haemodialysis session can rapidly eliminate a substantial amount of dabigatran from the central compartment with a concomitant marked reduction in its anticoagulant activity. There was a clinically negligible redistribution of dabigatran after haemodialysis. These results demonstrate that haemodialysis can be a suitable approach to eliminate dabigatran in emergency situations. PMID: 23389759 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Authors: Khadzhynov D, Wagner F, Formella S, Wiegert E, Moschetti V, Slowinski T, Neumayer HH, Liesenfeld KH, Lehr T, Härtter S, Friedman J, Peters H, Clemens A Tags: Thromb Haemost Source Type: research

Acute heart failure after thrombotic thrombocytopenic purpura successfully treated by ECLS
Source: Transfusion Medicine - February 7, 2013 Category: Hematology Authors: Q. De Landtsheer, L. Labriola, F. Houssiau, L.‐M. Jacquet, P. Hantson Tags: LETTER TO THE EDITOR Source Type: research

Anaemia and transfusion in nonagenarians undergoing emergency, non‐traumatic surgery: a prospective observational study
ConclusionsThe independent transfusion predictors in nonagenarians should be taken into account for cross‐matching. Transfusional policy being similar between nonagenarians and third‐aged patients; the differences in thresholds were due to the differences in the populations.
Source: Transfusion Medicine - February 7, 2013 Category: Hematology Authors: A. D. Pelavski, M. Miguel, A. Lacasta, M. I. Rochera, M. Roca Tags: ORIGINAL ARTICLE Source Type: research

Join ISTH
Source: Journal of Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Tags: ANNOUNCEMENTS Source Type: research

Erratum
Source: Journal of Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Tags: Erratum Source Type: research

Clinical characteristics and risk factors of pulmonary embolism: data from a Saudi tertiary‐care center
Source: Journal of Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Authors: F. H. AlGAHTANI, N. BAYOUMI, A. ABDELGADIR, N. AL‐NAKSHABANDI, Z. AL ASERI, M. AL GHAMDI, E. AL SAEED Tags: Letters to the Editor Source Type: research

Pretreatment platelet reactivity contribution to residual, post‐treatment platelet reactivity in prasugrel‐treated and ticagrelor‐treated patients
Source: Journal of Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Authors: D. Alexopoulos, I. Xanthopoulou, P. Davlouros, G. Tsigkas, A. Damelou, K. C. Theodoropoulos, V. Gkizas, G. Hahalis Tags: Letters to the Editor Source Type: research

Assessment of high on‐treatment platelet reactivity in patients with ischemic heart disease: concordance between the Multiplate and VerifyNow assays
Source: Journal of Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Authors: L. CONSUEGRA‐SÁNCHEZ, R. LÓPEZ‐PALOP, P. CANO, P. CARRILLO, F. PICÓ, M. VILLEGAS, J. SANCHIS, J. C. KASKI Tags: Letters to the Editor Source Type: research

Protein Z, protein Z‐dependent protease inhibitor (serpinA10), and the acute‐phase response
Source: Journal of Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Authors: T. J. GIRARD, N. M. LASKY, E. A. TULEY, G. J. BROZE Tags: Letters to the Editor Source Type: research

The VKORC1 and CYP2C9 genotypes are associated with over‐anticoagulation during initiation of warfarin therapy in children
Source: Journal of Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Authors: T. T. BISS, P. J. AVERY, M. D. WILLIAMS, L. R. BRANDÃO, J. D. GRAINGER, F. KAMALI Tags: Letters to the Editor Source Type: research

Recommendations for point‐of‐care home International Normalized Ratio testing in children on vitamin K antagonist therapy
Source: Journal of Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Authors: M. E. BAUMAN, A. BRUCE, S. JONES, F. NEWALL, M. P. MASSICOTTE, P. MONAGLE Tags: Official Communication of the SSC Source Type: research

Induction of platelet aggregation after a direct physical interaction with diesel exhaust particles
Conclusions: DEP associate physically with platelets in parallel with a Ca2+‐mediated aggregation response displaying the conventional features of agonist‐induced aggregation. The ability of DEP to enhance the aggregation response to platelet stimuli would be expected to increase the incidence of platelet‐driven cardiovascular events should they be inhaled and translocate into the blood. This study provides a potential mechanism for the increased thrombotic risk associated with exposure to ambient particulate air pollution.
Source: Journal of Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Authors: A. SOLOMON, E. SMYTH, N. MITHA, S. PITCHFORD, A. VYDYANATH, P. K. LUTHER, A. J. THORLEY, T. D. TETLEY, M. EMERSON Tags: ORIGINAL ARTICLE Source Type: research

Nuclear factor (NF)‐κB and its associated pathways are major molecular regulators of blood‐induced joint damage in a murine model of hemophilia
ConclusionsThese data suggest that NF‐κB‐associated signaling pathways are involved in the development of hemophilic arthropathy.
Source: Journal of Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Authors: D. Sen, A. Chapla, N. Walter, V. Daniel, A. Srivastava, G. R. Jayandharan Tags: Original Article Source Type: research

Anti‐PF4/heparin antibodies and venous graft occlusion in postcoronary artery bypass surgery patients randomized to postoperative unfractionated heparin or fondaparinux thromboprophylaxis
ConclusionsFondaparinux vs. UFH thromboprophylaxis postCABG does not reduce anti‐PF4/heparin antibody formation. Non‐platelet‐activating anti‐PF4/heparin IgG antibodies generated post operatively are associated with early venous graft occlusion.
Source: Journal of Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Authors: T. E. WARKENTIN, J. I. SHEPPARD, J. C. J. SUN, H. JUNG, J. W. EIKELBOOM Tags: Original Article Source Type: research

Presence of the JAK2 V617F Mutation in a Patient with Chronic Neutrophilic Leukemia and Effective Response to Interferon Alfa-2b.
Abstract Chronic neutrophilic leukemia (CNL) is a rare type of leukemia characterized by a proliferation mainly of mature neutrophils, elevated neutrophil-alkaline phosphatase activity, and no presence of the Philadelphia chromosome. The prognosis is generally poor and there is no consensus therapeutic strategy for the treatment of this disease. The JAK2 V617F mutation has been detected in patients with classical myeloproliferative disorders (MPD) including polycythemia vera and essential thrombocythemia and idiopathic myelofibrosis. In contrast, this same mutation has been detected in only 4 patients with CNL to d...
Source: Acta Haematologica - February 7, 2013 Category: Hematology Authors: Zhang X, Pan J, Guo J Tags: Acta Haematol Source Type: research

Novel Immunosuppression Compounds and Experimental Therapies for Chronic Graft-Versus-Host Disease.
Abstract Chronic graft-versus-host disease (GVHD) is a severe complication of allogeneic stem cell transplantation, with a substantial impact on the quality of life and survival, still lacking with regard to an optimal therapeutic strategy. Corticosteroids are considered the standard of care for first-line treatment of chronic GVHD, but only a minority of the patients responds to them durably. Management of steroid-refractory chronic GVHD is not well defined. This review surveys novel treatment strategies, such as therapies that expand regulatory T cells, target B cells or target the processes implicated in fibrosi...
Source: Acta Haematologica - February 7, 2013 Category: Hematology Authors: Michael M, Shimoni A, Nagler A Tags: Acta Haematol Source Type: research

JAK2 V617F mutation positive primary myelofibrosis with concomitant t(9;11;22)(q34;p15;q11.2) but no BCR/ABL fusion.
PMID: 23389763 [PubMed - as supplied by publisher]
Source: International Journal of Hematology - February 7, 2013 Category: Hematology Authors: Au WY, Wan TS, Ma ES Tags: Int J Hematol Source Type: research

New autoimmune diseases after cord blood transplantation: a retrospective study of EUROCORD and the Autoimmune Disease Working Party of the European Group for Blood and Marrow Transplantation
Key Points Autoimmune diseases do occur after CBT in approximately 5% of patients. Of these, AIHA or ITP were observed the most often and were treated with prednisone, CSA, and RTX.
Source: Blood - February 7, 2013 Category: Hematology Authors: Daikeler, T., Labopin, M., Ruggeri, A., Crotta, A., Abinun, M., Hussein, A. A., Carlson, K., Cornillon, J., Diez-Martin, J. L., Gandemer, V., Faraci, M., Lindemans, C., O'Meara, A., Mialou, V., Renard, M., Sedlacek, P., Sirvent, A., Socie, G., Sora, F., V Tags: Pediatric Hematology, Transplantation, Free Research Articles Source Type: research

Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy
Key Points Restricting transgenic antigen expression to differentiated antigen-presenting cells protects hematopoietic progenitors from immune attack. Restricting transgenic antigen expression to differentiated antigen-presenting cells promotes tolerogenic outcomes.
Source: Blood - February 7, 2013 Category: Hematology Authors: Coleman, M. A., Bridge, J. A., Lane, S. W., Dixon, C. M., Hill, G. R., Wells, J. W., Thomas, R., Steptoe, R. J. Tags: Transplantation Source Type: research

Distinct characteristics of antibody responses against factor VIII in healthy individuals and in different cohorts of hemophilia A patients
Key Points Antibodies against factor VIII show distinct characteristics in healthy individuals and different cohorts of hemophilia A patients. IgG4 antibodies against FVIII are only found in patients with inhibitors but not in healthy individuals or patients without inhibitors.
Source: Blood - February 7, 2013 Category: Hematology Authors: Whelan, S. F. J., Hofbauer, C. J., Horling, F. M., Allacher, P., Wolfsegger, M. J., Oldenburg, J., Male, C., Windyga, J., Tiede, A., Schwarz, H. P., Scheiflinger, F., Reipert, B. M. Tags: Free Research Articles, Thrombosis and Hemostasis Source Type: research

Aberrant 3' oligoadenylation of spliceosomal U6 small nuclear RNA in poikiloderma with neutropenia
Key Points Crystal structure of human USB1 identifies it as a member of the LigT-like superfamily of 2H phosphoesterases. USB1 protects spliceosomal U6 small nuclear RNA from aberrant 3' oligoadenylation.
Source: Blood - February 7, 2013 Category: Hematology Authors: Hilcenko, C., Simpson, P. J., Finch, A. J., Bowler, F. R., Churcher, M. J., Jin, L., Packman, L. C., Shlien, A., Campbell, P., Kirwan, M., Dokal, I., Warren, A. J. Tags: Pediatric Hematology, Phagocytes, Granulocytes, and Myelopoiesis Source Type: research

Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis
Key Points Ex vivo isolated myeloid populations of the mononuclear phagocyte network display specific microRNA expression signatures. miR-142–deficient mice display a reduction of splenic CD4+ dendritic cells resulting in impaired priming of CD4 T-cell responses.
Source: Blood - February 7, 2013 Category: Hematology Authors: Mildner, A., Chapnik, E., Manor, O., Yona, S., Kim, K.-W., Aychek, T., Varol, D., Beck, G., Itzhaki, Z. B., Feldmesser, E., Amit, I., Hornstein, E., Jung, S. Tags: Phagocytes, Granulocytes, and Myelopoiesis Source Type: research

Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice
Key Points During inflammation, serotonin released by platelets activates vessel wall promoting leukocyte adhesion and recruitment. Absence of platelet serotonin improves survival after lipopolysaccharide-induced endotoxic shock.
Source: Blood - February 7, 2013 Category: Hematology Authors: Duerschmied, D., Suidan, G. L., Demers, M., Herr, N., Carbo, C., Brill, A., Cifuni, S. M., Mauler, M., Cicko, S., Bader, M., Idzko, M., Bode, C., Wagner, D. D. Tags: Phagocytes, Granulocytes, and Myelopoiesis, Platelets and Thrombopoiesis Source Type: research

Retinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in vitro and in a neutropenic mouse model
Key Points Neutrophils mobilized by Am80 display greater bactericidal activity than those by G-CSF. These findings suggest a molecular rationale for developing new therapy for neutropenia by using Am80 as a cost-effective treatment option.
Source: Blood - February 7, 2013 Category: Hematology Authors: Ding, W., Shimada, H., Li, L., Mittal, R., Zhang, X., Shudo, K., He, Q., Prasadarao, N. V., Wu, L. Tags: Phagocytes, Granulocytes, and Myelopoiesis Source Type: research

Macrophage microvesicles induce macrophage differentiation and miR-223 transfer
Key Points Macrophage-derived microvesicles induced cellular differentiation in naive monocytes. Macrophage-derived microvesicles shuttle of miRNAs to target cells.
Source: Blood - February 7, 2013 Category: Hematology Authors: Ismail, N., Wang, Y., Dakhlallah, D., Moldovan, L., Agarwal, K., Batte, K., Shah, P., Wisler, J., Eubank, T. D., Tridandapani, S., Paulaitis, M. E., Piper, M. G., Marsh, C. B. Tags: Phagocytes, Granulocytes, and Myelopoiesis Source Type: research

CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia
Key Points CUX1 is a transcription factor encoded on a region of chromosome 7 that is frequently deleted in high-risk acute myeloid leukemia. Haploinsufficiency of CUX1/cut promotes hematopoietic overgrowth in both Drosophila melanogaster and human xenograft mouse models in vivo.
Source: Blood - February 7, 2013 Category: Hematology Authors: McNerney, M. E., Brown, C. D., Wang, X., Bartom, E. T., Karmakar, S., Bandlamudi, C., Yu, S., Ko, J., Sandall, B. P., Stricker, T., Anastasi, J., Grossman, R. L., Cunningham, J. M., Le Beau, M. M., White, K. P. Tags: Myeloid Neoplasia Source Type: research

Impact of oxygen concentration on growth of mesenchymal stromal cells from the marrow of patients with chronic lymphocytic leukemia
Key Points Physiologic O2 levels in vitro enhance the propagation and function of mesenchymal stromal cells from chronic lymphocytic leukemia patients.
Source: Blood - February 7, 2013 Category: Hematology Authors: Fecteau, J.-F., Messmer, D., Zhang, S., Cui, B., Chen, L., Kipps, T. J. Tags: Lymphoid Neoplasia, Brief Reports Source Type: research

PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells
Key Points PU.1 is a potent tumor suppressor in cHL cells and the induction of PU.1 is a possible therapeutic option for patients with cHL.
Source: Blood - February 7, 2013 Category: Hematology Authors: Yuki, H., Ueno, S., Tatetsu, H., Niiro, H., Iino, T., Endo, S., Kawano, Y., Komohara, Y., Takeya, M., Hata, H., Okada, S., Watanabe, T., Akashi, K., Mitsuya, H., Okuno, Y. Tags: Lymphoid Neoplasia Source Type: research

Early and nonreversible decrease of CD161++/MAIT cells in HIV infection
Key Points The frequency of CD161++ MAIT cells is dramatically decreased in the blood of HIV-infected patients, and they are nonrecoverable with HAART. Gut sequestration and apoptosis in response to bacterial signals may, amongst others, be mechanisms that contribute to this.
Source: Blood - February 7, 2013 Category: Hematology Authors: Cosgrove, C., Ussher, J. E., Rauch, A., Gartner, K., Kurioka, A., Huhn, M. H., Adelmann, K., Kang, Y.-H., Fergusson, J. R., Simmonds, P., Goulder, P., Hansen, T. H., Fox, J., Gunthard, H. F., Khanna, N., Powrie, F., Steel, A., Gazzard, B., Phillips, R. E. Tags: Immunobiology Source Type: research

Platelets support a protective immune response to LCMV by preventing splenic necrosis
Key Points Levels of circulating platelets determine the degree of pathology observed during arenavirus infections. While moderate platelet drops result in deficient immune control of an LCMV infection, severe platelet-drops result in systemic hemorrhages.
Source: Blood - February 7, 2013 Category: Hematology Authors: Loria, G. D., Romagnoli, P. A., Moseley, N. B., Rucavado, A., Altman, J. D. Tags: Immunobiology, Platelets and Thrombopoiesis Source Type: research

Myelopoiesis is regulated by osteocytes through Gs{alpha}-dependent signaling
Key Points Deletion of Gsα in osteocytes induces severe osteopenia and a dramatic expansion of cells of the myeloid lineage. Osteocytes regulate hematopoiesis and specifically contribute to myelopoiesis by secreting proliferative factors such as G-CSF.
Source: Blood - February 7, 2013 Category: Hematology Authors: Fulzele, K., Krause, D. S., Panaroni, C., Saini, V., Barry, K. J., Liu, X., Lotinun, S., Baron, R., Bonewald, L., Feng, J. Q., Chen, M., Weinstein, L. S., Wu, J. Y., Kronenberg, H. M., Scadden, D. T., Divieti Pajevic, P. Tags: Hematopoiesis and Stem Cells Source Type: research

LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance
Key Points Notch1/DII4-mediated signals are normally suppressed by LRF, preventing HSCs from premature T-cell differentiation in the bone marrow. Erythroblastic islands may have the capacity to regulate the fate and function of HSCs.
Source: Blood - February 7, 2013 Category: Hematology Authors: Lee, S.-U., Maeda, M., Ishikawa, Y., Li, S. M., Wilson, A., Jubb, A. M., Sakurai, N., Weng, L., Fiorini, E., Radtke, F., Yan, M., MacDonald, H. R., Chen, C.-C., Maeda, T. Tags: Hematopoiesis and Stem Cells Source Type: research

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells
Key Points Supraphysiologic Notch signals that maintain T-ALL self-renewal promote HSC differentiation at the expense of HSC self-renewal.
Source: Blood - February 7, 2013 Category: Hematology Authors: Chiang, M. Y., Shestova, O., Xu, L., Aster, J. C., Pear, W. S. Tags: Hematopoiesis and Stem Cells, Lymphoid Neoplasia Source Type: research

Genome-wide study of methotrexate clearance replicates SLCO1B1
Key Points A genome-wide study of the association of over 5 million SNPs with methotrexate clearance in 1279 patients treated with HDMTX in multicenter COG trials 9904 and 9905. We replicated the finding that inherited variations in SLCO1B1 are the most important genetic variations influencing methotrexate clearance.
Source: Blood - February 7, 2013 Category: Hematology Authors: Ramsey, L. B., Panetta, J. C., Smith, C., Yang, W., Fan, Y., Winick, N. J., Martin, P. L., Cheng, C., Devidas, M., Pui, C.-H., Evans, W. E., Hunger, S. P., Loh, M., Relling, M. V. Tags: Pediatric Hematology, Clinical Trials and Observations Source Type: research

Carfilzomib
This spotlight review focuses on the second-generation proteasome inhibitor carfilzomib, which was recently approved by the US Food and Drug Administration for treatment of relapsed and refractory multiple myeloma patients who have received at least 2 prior therapies, including bortezomib and an immunomodulatory agent, and have demonstrated disease progression on or within 60 days of the completion of the last therapy. This review focuses on clinical trial data leading to drug approval and provides advice for treating physicians who are now accessing this drug for patients.
Source: Blood - February 7, 2013 Category: Hematology Authors: Kortuem, K. M., Stewart, A. K. Tags: Free Research Articles, Lymphoid Neoplasia, 50 Most Cited Articles BLOOD SPOTLIGHT Source Type: research

Improving overall survival and overcoming adverse prognosis in the treatment of cytogenetically high-risk multiple myeloma
Multiple myeloma (MM) is a heterogeneous disease with certain genetic features [eg, t(4;14), del17p] associated with worse outcome. The introduction of thalidomide, lenalidomide, and bortezomib has dramatically improved the outlook for patients with MM, but their relative benefit (or harm) for different genetic patient subgroups remains unclear. Unfortunately, the small number of patients in each subgroup frequently limits the analysis of high-risk patients enrolled in clinical trials. Strategies that result in survival of high-risk genetic subgroups approximating that of patients lacking high-risk features are said to ove...
Source: Blood - February 7, 2013 Category: Hematology Authors: Bergsagel, P. L., Mateos, M.-V., Gutierrez, N. C., Rajkumar, S. V., San Miguel, J. F. Tags: Perspectives, Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research

Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes
Key Points High mortality rates are observed in patients with XIAP deficiency treated with myeloablative conditioning regimens for hematopoietic cell transplantation.
Source: Blood - February 7, 2013 Category: Hematology Authors: Marsh, R. A., Rao, K., Satwani, P., Lehmberg, K., Muller, I., Li, D., Kim, M.-O., Fischer, A., Latour, S., Sedlacek, P., Barlogis, V., Hamamoto, K., Kanegane, H., Milanovich, S., Margolis, D. A., Dimmock, D., Casper, J., Douglas, D. N., Amrolia, P. J., Ve Tags: Pediatric Hematology, Transplantation, Plenary Papers, Free Research Articles, Clinical Trials and Observations Source Type: research

On a WHIM
Source: Blood - February 7, 2013 Category: Hematology Authors: van Slambrouck, C. M., Gurbuxani, S. Tags: Blood Work, Phagocytes, Granulocytes, and Myelopoiesis Source Type: research

Poikiloderma with neutropenia: beginning at the end
Source: Blood - February 7, 2013 Category: Hematology Authors: Mason, P. J., Bessler, M. Tags: INSIDE BLOOD Source Type: research

miR-142 keeps CD4+ DCs in balance
Source: Blood - February 7, 2013 Category: Hematology Authors: Belz, G. T. Tags: INSIDE BLOOD Source Type: research

CUX1 in leukemia: dosage matters
Source: Blood - February 7, 2013 Category: Hematology Authors: Boultwood, J. Tags: INSIDE BLOOD Source Type: research

Arenaviruses bite the "dust"
Source: Blood - February 7, 2013 Category: Hematology Authors: Gomez, R. M., Schattner, M. Tags: INSIDE BLOOD Source Type: research

Osteocytes link bone maintenance to blood homeostasis
Source: Blood - February 7, 2013 Category: Hematology Authors: Link, D. C. Tags: INSIDE BLOOD Source Type: research

Ontogeny of erythroid gene expression
Key Points Comparative global gene expression analysis of primary murine primitive, fetal definitive, and adult definitive erythroid precursors. Primitive erythroblasts contain and accumulate high ROS levels and uniquely express the H2O2 transporting aquaporins 3 and 8.
Source: Blood - February 7, 2013 Category: Hematology Authors: Kingsley, P. D., Greenfest-Allen, E., Frame, J. M., Bushnell, T. P., Malik, J., McGrath, K. E., Stoeckert, C. J., Palis, J. Tags: Red Cells, Iron, and Erythropoiesis, e-Blood Source Type: research

Prognostic factors in gemcitabine‐cisplatin polychemotherapy regimens in pancreatic cancer: XPD‐Lys751Gln polymorphism strikes back
Abstract The use of platinated agents in combination chemotherapy regimens for advanced pancreatic cancer is controversial due to the lack of an outstanding impact on the outcome and a substantial increase in hematologic and extra‐hematologic toxicities. Pharmacogenetic studies to identify patients who could benefit most from such therapies are urgently needed. The Xeroderma‐Pigmentosum group‐D polymorphism at codon‐751 (XPD‐Lys751Gln) emerged as the most significant independent predictor for death‐ and progression‐risk in our previous study on functional polymorphisms in 122 advanced pancreatic cancer patien...
Source: International Journal of Cancer - February 7, 2013 Category: Cancer & Oncology Authors: Amir Avan, Paola Pacetti, Michele Reni, Michele Milella, Enrico Vasile, Andrea Mambrini, Vanja Vaccaro, Sara Caponi, Stefano Cereda, Godefridus J. Peters, Maurizio Cantore, Elisa Giovannetti Tags: Short Report Source Type: research

Fluorine-18 fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography scan contributes to the diagnosis and management of brucellar spondylodiskitis
Conclusions: Our study suggests that in patients with brucellar spondylodiskitis F-18 FDG PET/CT scan can provide additional information on the spread of the infection, compared to MRI. Successful treatment is associated with a significant decrease in SUVmax values; thus, PET/CT scan may be a complementary method for determining the efficacy of treatment.
Source: BMC Infectious Diseases - February 7, 2013 Category: Infectious Diseases Authors: Savvas IoannouSofia ChatziioannouSpiros PneumaticosAlexandra ZormpalaNikolaos Sipsas Source Type: research

Genetic variants associated with protein C levels
ConclusionsWe identified four genes at chromosome 5q14.1 that might influence normal PC levels. BHMT2 seems the most likely candidate to regulate PC levels via homocysteine, a competitive inhibitor to thrombin. Failure to replicate our findings in LETS might be due to differences between the studies in genetic background and linkage disequilibrium patterns.© 2013 International Society on Thrombosis and Haemostasis
Source: Journal of Thrombosis and Haemostasis - February 7, 2013 Category: Hematology Authors: C.Y. Vossen, B.P. Koeleman, S.J. Hasstedt, I.J. Nijman, I.J. Renkens, P.W. Callas, F.R. Rosendaal, E.G. Bovill Tags: Original Article ‐ Coagulation Source Type: research