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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 11.

My Dad on Exercise
Bullseye has walked four to six miles for exercise almost every day, for 25 years. When home, he’ll walk the same route around the neighborhood or on the treadmill if the weather is poor. He’ll also walk the same route when he’s on vacation at the beach (at the same hotel every year). At the last job he held for over 30 years, he walked the same blocks, or the same hallways if the weather was poor. Despite spending more time in Washington, D.C., than almost any other location throughout his life, he couldn’t tell me about his surroundings, where landmarks are, or how to get anywhere. “What do I care where you y...
Source: I've Still Got Both My Nuts: A True Cancer Blog - February 17, 2013 Category: Cancer Tags: family Source Type: blogs

Continuous beta lactam infusion
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - February 16, 2013 Category: Internists and Doctors of Medicine Tags: infectious disease Source Type: blogs

Top stories in health and medicine, February 15, 2013
This series is brought to you by MedPage Today.1. Repealing SGR Raises Questions for Congress. Opinions on what to replace Medicare’s sustainable growth rate (SGR) formula with and how to get there vary greatly.2. Depression May Lower Response to Shingles Vax. Untreated major depression may hamper the protective effect of varicella zoster virus (VZV) vaccine against herpes zoster — shingles — in older individuals.3. Contraception: Condoms Are King, Plan B Takes Hold. In the realm of contraception, the condom reigns supreme, but one in 10 have used emergency contraception such as Plan B. Manage your online...
Source: Kevin, M.D. - Medical Weblog - February 15, 2013 Category: Family Physicians Tags: News Infectious disease OB/GYN Source Type: blogs

2013 edition of GIDEON eBooks with maps
The 2013 edition of GIDEON eBooks has been released. This new edition includes distribution maps for each disease. A example of the distribution map of Tuberculosis is included below. The entire series now contains 105,467 pages of text, graphs and maps in 419 eBooks. The GIDEON eBook titles are divided into two series. The country series, offers a complete text devoted to the Infectious Diseases of every individual country. In addition there are 2 other eBooks. Infectious Diseases of the World covers the worldwide status of every disease including distribution maps. Infectious Diseases and Bioterrorism includes all Infect...
Source: GIDEON blog - February 13, 2013 Category: Databases & Libraries Authors: Uri Blackman Tags: Ebooks Source Type: blogs

Policy-based evidence. Department of Health and Prince’s Foundation censor accurate information about magic medicines
This report is really quite contentious and we may well be subject to quite a lot of challenge from the Homeopathic community if published. What on earth? The DH seems to think that that its job is not to present the evidence, but to avoid challenges from the homeopathic community! And true enough, this piece is missing from the final version. A bit later, the NHS Choices draft was censored again “A 2010 Science and Technology Committee report said that scientific tests had shown that homeopathic treatments don’t work” But again this doesn’t appear in the final version. The comment, apparently fr...
Source: DC's goodscience - February 13, 2013 Category: Professors and Educators Authors: David Colquhoun Tags: CAM CNHC College of Medicine Department of Health George Lewith homeopathy Michael Dixon National Health Service Prince of Wales Prince's Foundation Academia alternative medicine badscience David Mattin Sunjai Gupta Source Type: blogs

Update: February 13, 2013
GIDEON what’s new summary: February 8 to February 13, 2013 Infectious Diseases – Outbreaks (2 updates) 2 DiseasesMap Infectious Diseases – Diseases (582 updates) 117 Diseases465 Country notesMap Infectious Diseases – Drugs (4 updates) 2 Drugs2 Interacting drugs – New Infectious Diseases – Vaccines (1 updates) 1 New Vaccine Synonyms Added (Source: GIDEON blog)
Source: GIDEON blog - February 13, 2013 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: What's New Source Type: blogs

Shire to Forest on Deal List for AstraZeneca: Real M&A - Bloomberg
For AstraZeneca Plc to reverse its worst profit slide, the drugmaker needs to make its biggest purchase since at least 2007. AstraZeneca reported a 37 percent drop in 2012 earnings and forecast profit this year will decline “significantly more than revenue” after the $59 billion company suffered setbacks in developing new therapies to replace best-selling drugs that are losing patent protection. While Chief Executive Officer Pascal Soriot said he will focus on internal efforts and purchases of $3 billion to $4 billion to help boost the lowest valuations in the industry, Exane BNP Paribas said only a “transformational...
Source: PharmaGossip - February 12, 2013 Category: Pharma Commentators Authors: insider Source Type: blogs

Needle exchanges: When the perfect is the enemy of the good
Between 7:30 and 10 a.m. on a glacial late November morning, a tall white van lingers at a street corner in Boston’s South End. I consult my iPhone one more time to confirm that I’m in the right place and knock on the vehicle’s glass-paned door. Ritchie, with his oversized Las Vegas baseball cap and faint smell of cigarettes, ushers me inside and I settle in across from him on one of the grey-upholstered seats to await the van’s more typical visitors.Continue reading ... Manage your online reputation: A complete social media guide. Read the book by KevinMD. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 11, 2013 Category: Family Physicians Tags: Physician Infectious disease Primary care Source Type: blogs

Healthcare Update — 02-11-2013
Patients gone wild. Also, a perfect example of why doctors shouldn’t play security guard. Iowa man attempts to leave emergency department, doctor doesn’t allow him to do so. Patient then slams doctor against wall and puts doctor into a choke hold before being pulled off and restrained. Who gets paid to study this stuff? “Researchers” find that number of ED visits for pubic hair grooming injuries is on the rise. I had a couple of snarky comments, but I’ll have to leave those to you all. Possible hope in battling drug-resistant superbugs? Scientists discover how to manipulate genes in bacteria to prevent bacteria f...
Source: WhiteCoat's Call Room - February 11, 2013 Category: Emergency Medicine Doctors Authors: WhiteCoat Tags: Healthcare Update Source Type: blogs

TWiV 219: Fauci pharmacy
On episode #219 of the science show This Week in Virology, Vincent and Rich meet up with Anthony S. Fauci, MD, Director of the National Institute of Allergy and Infectious Diseases. You can find TWiV #219 at www.twiv.tv. (Source: virology blog)
Source: virology blog - February 10, 2013 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology AIDS Anthony S. Fauci hepatitis C virus HIV influenza niaid NIH SARS viral Source Type: blogs

A virtual office visit for your cold is not a good idea
A version of this column was published on January 13, 2013 in USA Today.Like many other primary care doctors across the country, I’m seeing my fair share of patients with runny noses during this winter season.I recently saw a patient for a sinus infection whom asked, “Why did I have to come in to see you? Couldn’t you have given me an antibiotic over the Internet?”If health insurers had their way, more doctors would be seeing patients and possibly prescribing medications online. However, I would be wary of this scenario.Continue reading ... Manage your online reputation: A complete social media guide. Read the boo...
Source: Kevin, M.D. - Medical Weblog - February 10, 2013 Category: Family Physicians Tags: Kevin's Take Infectious disease Primary care Source Type: blogs

The Cricket Symphony: Surviving Childhood Without Social Skills
Every cricket had a job all throughout my childhood. Each time my mouth opened, the symphony began. People would look at me quizzically, alarmed by my nonsensical humor and lack of social understanding. One time, during Peter Pan practice rehearsal (I was Tootles, one of the lost boys), a girl complained of a mosquito bite. She reached over to scratch it as I laughed. What I wanted to say is “I am sorry you hurt your leg. That must really hurt.” But what came out was a short, tight, laugh. She looked at me with a pained expression on her face, noting out loud that I was weird. I felt bad, but I grinned at her exaggerat...
Source: Occupational Therapy Students (B)e(LO)n(G) - February 10, 2013 Category: Occupational Therapists Source Type: blogs

Sunday News Round-Up – Dolly Parton Flips the Bird Edition
Tennessee state Senator Stacey Campfield brought back the “Don’t say gay” bill to forbid teachers from discussing sexualities other than heterosexuality. He was rightfully mocked on the Colbert Report for this and other bills he’s filed. The bill (SB 234) technically forbids discussion of anything “inconsistent with natural human reproduction” – because, you know, all sex results in reproduction and all straight people are capable of reproducing. Worst, though, is that it requires teachers and school counselors who talk to a student who might be questioning their sexuality to notif...
Source: Women's Health News - February 10, 2013 Category: Medical Librarians Authors: Rachel Tags: Abortion Abuse, Rape, & Safety Access, Rights, & Choice Adolescent Health Birth Breastfeeding Ethics Government Infectious Diseases Laws, Legislation, & Courts Miscellaneous News Round-Ups Sex & Sex Education Armenia birth cent Source Type: blogs

Death by Infection, the End of Modern Medicine
A post-antibiotic era means, in effect, an end to modern medicine as we know it. Things as common as strep throat or a child’s scratched knee could once again kill. ~ Dr Margaret Chan, Director-General of the World Health Organization Alzheimer's Reading Room In its recent annual report on global risks, the World Economic Forum (WEF) concluded that “arguably the greatest risk . . . to human health comes in the form of antibiotic-resistant bacteria. We live in a bacterial world where we will never be able to stay ahead of the mutation curve. A test of our resilience is how far behind the curve we allow ourselves t...
Source: Alzheimer's Reading Room, The - February 10, 2013 Category: Dementia Authors: Bob DeMarco Source Type: blogs

Why Am I Still Here?
It's a question I hear from time to time: "I've been in therapy for years.  How come I'm not better by now?"   Okay, so psychiatric conditions are not like infections, at least not for some people; you can take a week of antibiotics and your urinary tract infection is all gone.   Your bipolar disorder may take a wee bit longer to stabilize. ~ Not only that, but this is something that's different for everyone, some people seek treatment for a single episode of depression, for a help coping with a stressful life event, or for help to change a maladaptive pattern, and they come for a short time, fig...
Source: Shrink Rap - February 10, 2013 Category: Psychiatrists and Psychologists Authors: Dinah Source Type: blogs

Why I hold off on antibiotics for my cough
For as long as I can remember I have tended to develop a bad cough nearly every time I get sick in the cold and flu season. I’m not sure if I have a minor tendency to bronchospasm or if my years of passive smoke exposure as a child somehow damaged my lungs. Who knows, but I seem to have the tendency for every URI become a lingering brohchitic cough.Continue reading ... Manage your online reputation: A complete social media guide. Read the book by KevinMD. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 9, 2013 Category: Family Physicians Tags: Meds Infectious disease Medications Primary care Source Type: blogs

Update: February 8, 2013
GIDEON what’s new summary: February 6 to February 8, 2013 Infectious Diseases – Outbreaks (3 updates) 3 DiseasesMap Infectious Diseases – Diseases (361 updates) 1 Clinical note53 Diseases307 Country notesMap (Source: GIDEON blog)
Source: GIDEON blog - February 8, 2013 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: What's New Source Type: blogs

Thomas Stossel: Honored with Brigham and Women’s Humanitarian Award
Each year, members of the Hippocrates Society present a Humanitarian Award to a physician or scientist practicing at Brigham and Women’s Hospital (BWH) in recognition of his or her contributions to the institution and the community.  Candidates are nominated and voted on by members of the Hippocrates Society, and members are eligible to receive the award.   The Humanitarian Award is the highest honor handed down by the Hippocrates Society, which is comprised of BWH physicians and scientists who make philanthropic gifts to BWH.  It is presented annually in recognition of outstanding contributions to the local and glob...
Source: Policy and Medicine - February 8, 2013 Category: Health Medicine and Bioethics Commentators Authors: Thomas Sullivan Source Type: blogs

Job Posting: Medical Officer
Medical Officer The Henry M. Jackson Foundation Bethesda, MD HJF is seeking a Medical Officer to provide support under the an NIH-funded contract to the Division of AIDS (DAIDS) at the National Institute of Allergy and Infectious Diseases (NIAID), a component of NIH, located on Rockledge Drive in Bethesda, Maryland. Under the NIH Contract, HJF’s seperate operating division, HJF-DAIDS, provides scientific and operations support to DAIDS including the Therapeutics Research Program. The incumbent will provide clinical research support to the of as part of the HJF-DAIDS Program. Responsible for assisting DAIDS in the prep...
Source: Non-Clinical Physician Jobs, Careers, and Opportunities - February 7, 2013 Category: Technology Consultants Authors: Joseph Kim, MD, MPH Source Type: blogs

Answers to common vaccine questions from patients
One of the true joys of being a primary care doctor is partnering and educating patients to make the best decision for themselves and their families. Though they may not always agree with what I have to say, at least I know I’ve done my best to give them the information they need to be informed. What follows are common conversations I have with patients. The bolded statements are what a few patients say when they first decline getting vaccinated.What reasons have you heard?Continue reading ... Manage your online reputation: A complete social media guide. Read the book by KevinMD. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 6, 2013 Category: Family Physicians Tags: Meds Infectious disease Primary care Source Type: blogs

Update: February 6, 2013
GIDEON what’s new summary: February 6 to February 6, 2013 Infectious Diseases – Diseases (2 updates) 1 Disease1 Country noteMap (Source: GIDEON blog)
Source: GIDEON blog - February 6, 2013 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: What's New Source Type: blogs

Clostridium difficile: A fecal transplant when all else fails
The bacteria that live in our healthy guts are a garden of cooperating and competing species that help to determine our intestinal health. When we take antibiotics, we kill countless bystander bacteria in our guts and sometimes develop changes in our digestion which can be severe. Clostridium difficile infection is one of these conditions, a superinfection with a bacterium which is pretty resistant to antibiotics and causes infection of the colon with diarrhea, sometimes fever, nausea and vomiting and occasionally death. We treat Clostridium difficile (C. diff) diarrhea with a couple of antibiotics to which it is sensitive...
Source: Kevin, M.D. - Medical Weblog - February 6, 2013 Category: Family Physicians Tags: Conditions GI Infectious disease Source Type: blogs

Update: February 6, 2013
GIDEON what’s new summary: February 6 to February 6, 2013 Infectious Diseases – Diseases (2 updates) 1 Disease1 Country noteMap (Source: GIDEON blog)
Source: GIDEON blog - February 6, 2013 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: What's New Source Type: blogs

Update: February 6, 2013
GIDEON what’s new summary: January 31 to February 6, 2013 Infectious Diseases – Outbreaks (10 updates) 10 DiseasesMap Infectious Diseases – Diseases (513 updates) 104 Diseases409 Country notesMap Infectious Diseases – Drugs (2 updates) 1 Drug1 Interacting drugs – New (Source: GIDEON blog)
Source: GIDEON blog - February 6, 2013 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: What's New Source Type: blogs

Why doctors and nurses should be required to have flu shots
I was recently speaking to the clinical leaders of a mid-sized hospital, and a senior administrator posed the question, “should we require our doctors and nurses to get flu shots?” The answer, I said, is yes, and it isn’t just to prevent the flu. It’s to get into the habit of making our folks do the right thing when it comes to patient safety.Continue reading ... Manage your online reputation: A complete social media guide. Read the book by KevinMD. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 5, 2013 Category: Family Physicians Tags: Physician Infectious disease Palliative care Source Type: blogs

Angiostrongyliasis in Taiwan
The following background on angiostrongyliasis in Taiwan was abstracted from Gideon www.GideonOnline.com and the Gideon e-book series. [1,2] =Time and Place: - Angiostrongyliasis was first reported in Taiwan in 1945. - The disease is most common among children, with highest rates during the summer rainy season. - Infection is often diagnosed among Thai laborers who ingest raw snails (Ampullarium canaliculatus, Achatina fulica). - Angiostrongyliasis has been reported in a child who raised snails (Ampullarium canaliculatus) as pets. - 125 cases of angiostrongyliasis were reported in southern Taiwan during 1968 to 1969, with ...
Source: GIDEON blog - February 5, 2013 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: Ebooks Epidemiology ProMED angiostrongyliasis Taiwan Source Type: blogs

Towards a Goal that Can Never Be Attained
It is a polite fiction in some parts of the aging research community that the goal of the scientists' work is to improve health in the old without improving longevity. Like all the best polite fictions, it survives because many people have come to actually believe this line. It arose during the period when researchers couldn't talk openly about extending human life without risking their funding and their careers: proposing improvements to health in the old was the way to raise funds when you couldn't talk about extending healthy and overall life span. Sad to say, but the research and funding community was, up until compara...
Source: Fight Aging! - February 5, 2013 Category: Health Medicine and Bioethics Commentators Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

AMA News: Dangers of "EHR Sloppy and Paste" - And Why Was An Informatics Expert Apparently For "Anecdotes" Before He Was Against Them?
In the AMA News an article by Kevin O'Reilly appeared entitled "EHRs: “Sloppy and paste” endures despite patient safety risk."It addresses the dangers of a common feature of EHR's used recklessly:  copy-and-paste. EHRs: “Sloppy and paste” endures despite patient safety riskCopying and pasting information is common within EHRs, but the practice sometimes can lead to confusion and endanger patient care. By Kevin B. O'Reilly, amednews staff. Posted Feb. 4, 2013.During the winter holidays, a patient at Yale-New Haven Hospital in Connecticut had a large pressure ulcer with an abscess. A surgical intern made a note ...
Source: Health Care Renewal - February 4, 2013 Category: Health Medicine and Bioethics Commentators Tags: AMA News healthcare IT note cloning healthcare IT note copying Kevin O'Reilly healthcare IT anecdote Bill Hersh healthcare IT risks Source Type: blogs

New report: Strategies to Move from Sick Care to Health Care in Four Years
The Trust for America’s Health has released a new report entitled A Healthier America 2013: Strategies to Move from Sick Care to Health Care in Four Years.  The report provides high-impact prevention recommendations in 10 public health areas. reversing the obesity epidemic preventing tobacco use and exposure encouraging healthy aging improving the health of low-income and minority communities strengthening healthy women, healthy babies reducing environmental health threats enhancing injury prevention preventing and controlling infectious diseases prioritizing health emergencies and bioterrorism preparedness fixing...
Source: BHIC - February 4, 2013 Category: Databases & Libraries Authors: Kate Flewelling Tags: Articles Public Health Source Type: blogs

Continuous infusion Zosyn (Pip/Tazo)
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - February 3, 2013 Category: Internists and Doctors of Medicine Tags: pharmacology infectious disease Source Type: blogs

Expanding the Range of Low-Cost Molecular Diagnostics: Interview with Gregory Mouchka, Product Manager, Engineering & Applications, Rheonix Inc.
Here at Medgadget we’ve covered dozens of molecular and genetic diagnostics that utilize novel screening tools to identify disease. However, integrating these tools into the clinic is difficult: according to recent research by UnitedHealth, 77 percent of physicians say that the largest barrier to conducting genetic testing is the cost of tests for patients. Innovations cannot succeed on a large-scale unless they are affordable for patients. Thus, the push to develop lower-cost tests is more important than ever.Enter Rheonix, Inc., a maker of molecular diagnostic equipment based in Ithaca, N.Y. Rheonix has developed the...
Source: Medgadget - February 1, 2013 Category: Technology Consultants Authors: Ravi Parikh Tags: Diagnostics Medgadget Exclusive Source Type: blogs

Gram Positive Cockeye vs Cocci Explained.
Here's a letter I wrote to the National Academy of Nursing Vocabulary last week regarding my concerns about an epidemic of gram positive cockeye sweeping our hospitals.  You think the flu was bad this year?  You think C diff is bad.  You have no idea how aggressive the cockeye has been. Dear Academy, I have been a practicing hospitalist now for ten years.  I want to commend your organization's mission to improve nursing vocabulary.  Helping nurses achieve proficiency in medical terminology is important for doctor-nurse and nurse-nurse communication of critical patient information.  Quite obvi...
Source: The Happy Hospitalist - February 1, 2013 Category: Internists and Doctors of Medicine Authors: Tamer Mahrous Source Type: blogs

What is Killer Number 1 ?
If you ask people what the number one cause of death is, you will get a variety of answers. Some doctors will say it’s heart disease; others with a more global perspective will claim it’s infectious diseases; while social scists will say it’s poverty.However, I believe the single largest killer is health illiteracy. Let me explain. While some of us are fortunate enough to will die happily in our own beds of old age, most of us will suffer from an illness,  which will cause death as it progresses. When we are ill, we seek medical attention, and this means that the terminal event for most people in the developed w...
Source: The Patient's Doctor - February 1, 2013 Category: Obstetricians and Gynecologists Tags: Heart disease Health United States patient American Heart Association Conditions and Diseases List of causes of death by rate Infectious disease Source Type: blogs

Update: January 31, 2013
GIDEON what’s new summary: January 31 to January 31, 2013 Infectious Diseases – Diseases (19 updates) 7 Diseases12 Country notesMap Infectious Diseases – Drugs (2 updates) 2 Susceptibility database – New Microbiology – Bacteria (2 updates) 2 New Bacteria Added (Source: GIDEON blog)
Source: GIDEON blog - January 31, 2013 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: What's New Source Type: blogs

Update: January 31, 2013
GIDEON what’s new summary: January 21 to January 31, 2013 Infectious Diseases – Outbreaks (13 updates) 13 DiseasesMap Infectious Diseases – Diseases (767 updates) 141 Diseases626 Country notesMap Infectious Diseases – Drugs (1 updates) 1 Drug (Source: GIDEON blog)
Source: GIDEON blog - January 31, 2013 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: What's New Source Type: blogs

7 reasons to boycott the Super Bowl from a medical standpoint
You’ve probably watched the Super Bowl as I have many times, faithfully, elevating the occasion to some kind of macabre family tradition. It is a spectacle of athletic agility, drama, and struggle; the pinnacle of American sporting contests. Despite the heavy onslaught of commercialism, faux halftime culture, and evident violence on the field, we suspend our awareness that this event may not be a magical moment worth our time and validation, even as its winners call out to some magical Disney kingdom.Continue reading ... Read KevinMD's book: Establishing, Managing and Protecting Your Online Reputation: A Social Media Gu...
Source: Kevin, M.D. - Medical Weblog - January 30, 2013 Category: Family Physicians Tags: Physician Infectious disease Neurology Source Type: blogs

Top stories in health and medicine, January 27, 2013
This series is brought to you by MedPage Today.1. Statins May Lower Death Risk in Liver Ca. Statin use seemed to reduce the risk of death in patients with hepatocellular cancer.2. FDA Panel Votes for Tighter Controls on Vicodin. An FDA advisory committee voted 19 to 10 on Friday in favor of moving hydrocodone combination drugs such as Vicodin, Lortab, and Norco into the more restrictive schedule II category of controlled substances.3. Chlorhexidine Baths in PICU Cut Infections. Scrubbing children in intensive care units with chlorhexidine daily cut the incidence of bacteremia by more than 35% in a randomized, crossover tri...
Source: Kevin, M.D. - Medical Weblog - January 28, 2013 Category: Family Physicians Tags: News GI Infectious disease Source Type: blogs

Fossil perspective on economic growth
A paper from a researcher at Fukushima University caught my eye recently. Not least because it was from that university, but also because the city was in the news again because of proposals to plant a wind farm off the coast there. Moreover, the paper is about how fossil fuels drive economic growth…multiple ironies I’d say. Engineer Hazuki Ishida of the Faculty of Symbiotic Systems Science at the university begins his paper with the statement: “Fossil fuels are major sources of energy, and have several advantages over other primary energy sources. Without extensive dependence on fossil fuels, it is questi...
Source: Sciencebase Science Blog - January 27, 2013 Category: Medical Scientists Authors: David Bradley Tags: Science economic fossil growth perspective Source Type: blogs

Babesia Infection – Signs, Symptoms, and Treatment
Pathophysiology of Babesia Infection 1) Babesiosis is caused by the intracellular protozoan parasite Babesia microti and in Europe B. divergens 2) most severe symptoms occur in immunosuppressed, diabet6ic, splenectomized, and elderly 3) now clinically important in the USA and Candada as a coinfection of Lyme disease, ehrlichiosis, and Bartonella (which are all transmitted via the bite of the Ixodes tick) Signs and Symptoms 1) acute flu-like symptoms – fever, chills, sweats, muscle pain, fatigue, arthralgias, and headache 2) petechiae 3) jaundice/dark urine 4) if occurs as coinfection with Lyme disease, the clinical ...
Source: Inside Surgery - January 27, 2013 Category: Surgeons Authors: Editor Tags: Infectious Disease atovaquone babesia babesiosis bartonella coinfection ixodes Lyme microti tick Source Type: blogs

IBM will save the planet with this magical hydrogel - NOT
Well, press releases can drive me crazy.  And this one is one of the worst I have seen in a while: IBM News room - 2013-01-24 IBM and The Institute of Bioengineering and Nanotechnology Develop New Antimicrobial Hydrogel to Fight Superbugs and Drug-Resistant Biofilms - United States This new fangled gel they have made they are very proud of.  That is good.  Pride in ones work is a good thing.  But getting the science wrong and making misleading statements is not.  Some statements I have issues with include Able to colonize on almost any tissue or surface, microbial biofilms - which are adhes...
Source: The Tree of Life - January 26, 2013 Category: Medical Scientists Authors: Jonathan Eisen Source Type: blogs

Varicella-Zoster Virus Signs, Symptoms, and Treatment
Pathophysiology of Varicella-Zoster Virus Varicella-Zoster causes two separate disease 2) initial disease is chickenpox 3) after a latency period (can be decades) patients can develop zoster (shingles) Signs and Symptoms Chickenpox – 1) fever 2) malaise 3) painful vesicular rash, starting on head and spreading to limbs, mouth, vagina, and trunk that ulcerates and crusts over in 3-5 days 4) vesicles appear in crops (different areas of body have lesions in different stages) 5) in older children and adults, causes life-threatening interstitial (as opposed to a bacterial intra-alveolar) pneumonia with lung hemorrhage, co...
Source: Inside Surgery - January 25, 2013 Category: Surgeons Authors: Editor Tags: Infectious Disease Source Type: blogs

Big Joe: Living proof of our fallibility
When I think of Big Joe, I see his overalls, and how he filled them. And how a couple of months after I operated on him, there was room for both of us in there. Big Joe: farmer, salt of the earth, tough, stoic. On the day I met him, if it’d been Halloween, I might have tried to stick a candle in him. That’s how orange he was. My initial recommendation, while probably justified, damn near killed him.Continue reading ... Follow KevinMD.com on Facebook, Twitter, Google+, and LinkedIn. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 25, 2013 Category: Family Physicians Tags: Physician GI Infectious disease Surgery Source Type: blogs

Three Rings in a Row
Here's a structure that caught me eye, in this paper from Georgia State and Purdue. That's a nice-looking group stuck on the side of their HIV protease inhibitor; I don't think I've ever seen three fused THF rings before, and if I have, it certainly wasn't in a drug candidate. From the X-ray structure, it seems to be making some beneficial interactions out in the P2 site. This is an analog these are analogs of darunavir, which has two THFs fused in similar fashion. That compound's behavior in vivo is well worked out - most of the metabolism is cleavage of the carbamate. Both with and without that, there's a bunch of scatt...
Source: In the Pipeline - January 24, 2013 Category: Chemists Tags: Infectious Diseases Source Type: blogs

The LITFL Review 092
Welcome to the mind-blowing  92nd edition! The LITFL Review is your regular and reliable source for the highest highlights, sneakiest sneak peaks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the best and brightest from the blogosphere, the podcast video/audiosphere and the rest of the Web 2.0 social media jungle to find the most fantastic EM/CC FOAM (Free Open Access Meducation) around. The Most Fair Dinkum Ripper Beaut of the Week The Short Coat Top Spot this week is a ripper By Lauren looking at hypertension in the ED. Check our M...
Source: Life in the Fast Lane - January 23, 2013 Category: Emergency Medicine Doctors Authors: Kane Guthrie Tags: Education Emergency Medicine Featured Intensive Care LITFL review Trauma LITFL R/V Source Type: blogs

The LITFL Review 092
Welcome to the mind-blowing  92nd edition! The LITFL Review is your regular and reliable source for the highest highlights, sneakiest sneak peaks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the best and brightest from the blogosphere, the podcast video/audiosphere and the rest of the Web 2.0 social media jungle to find the most fantastic EM/CC FOAM (Free Open Access Meducation) around. The Most Fair Dinkum Ripper Beaut of the Week The Short Coat Top Spot this week is a ripper By Lauren looking at hypertension in the ED. Check our M...
Source: Life in the Fast Lane - January 23, 2013 Category: Emergency Medicine Doctors Authors: Kane Guthrie Tags: Education Emergency Medicine Featured Intensive Care LITFL review Trauma LITFL R/V Source Type: blogs

We cannot be complacent about drug resistant bacteria
This little cartoon, courtesy of xkcd, highlights a problem we have had for some time, but which is getting worse–highly antibiotic-resistant bacteria. Soon after the first antibiotics appeared, especially penicillin, doctors noticed the phenomenon of developing bacterial resistance to them. The cause is evolution in action. The replication time for bacteria is extremely fast, as short as twenty minutes in some cases. So the process of evolution, of random mutation and passing new traits on to offspring, happens in minutes rather than years.Continue reading ... Follow KevinMD.com on Facebook, Twitter, Google+, and Li...
Source: Kevin, M.D. - Medical Weblog - January 22, 2013 Category: Family Physicians Tags: Conditions Infectious disease Source Type: blogs

Viruses on Time
Poliovirus recently made the cover of Time magazine. Prompted by a reader question, I searched the Time archive to find out if there have been other virology-themed covers. I found fifteen in all, depicting poliovirus (3), herpesvirus (1), HIV/AIDS (4), influenza (5), and SARS coronavirus (2) (I did not distinguish between US and international editions). The earliest virus-themed cover that I found has Jonas Salk on the cover of the 29 March 1954 issue. Behind Salk is an image of poliovirus particles, probably drawn from an electron micrograph. Salk’s field trial of inactivated poliovirus vaccine had begun in 1954, a...
Source: virology blog - January 21, 2013 Category: Virology Authors: Vincent Racaniello Tags: Information AIDS H5N1 herpesvirus HIV influenza poliovirus SARS coronavirus Time magazine cover viral virology Source Type: blogs

Update: January 21, 2013
GIDEON what’s new summary: January 16 to January 21, 2013 Infectious Diseases – Outbreaks (4 updates) 4 DiseasesMap Infectious Diseases – Diseases (636 updates) 7 Clinical notes122 Diseases505 Country notes1 New Disease Synonym Added1 New Vectors AddedMap Infectious Diseases – Drugs (2 updates) 1 Drug1 Interacting drugs – New (Source: GIDEON blog)
Source: GIDEON blog - January 21, 2013 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: What's New Source Type: blogs

That Many Compounds in Development? Really?
So PhRMA has a press release out on the state of drug research, but it's a little hard to believe. This part, especially: The report, developed by the Analysis Group and supported by PhRMA, reveals that more than 5,000 new medicines are in the pipeline globally. Of these medicines in various phases of clinical development, 70 percent are potential first-in-class medicines, which could provide exciting new approaches to treating disease for patients. This set off discussion on Twitter and elsewhere about how these number could have been arrived at. Here's the report itself (PDF), and looking through it provides a few more...
Source: In the Pipeline - January 21, 2013 Category: Chemists Tags: Drug Development Source Type: blogs

Top stories in health and medicine, January 21, 2013
This series is brought to you by MedPage Today.1. Weight Stays Off Long Term After Bariatric Surgery. Obese patients maintained about 50% excess weight loss for as long as 15 years after laparoscopic adjustable gastric banding, (LAGB).2. Obama Take 2: Tobacco, Obesity Key in Second Term. The second term of an Obama administration will be marked for implementing key provisions of the Affordable Care Act (ACA), but the president also wants to focus on lowering tobacco use and obesity rates, a senior administration official said.3. Flu Epidemic: Fact or Fiction? Good hygiene might help keep the flu at bay, but there are some ...
Source: Kevin, M.D. - Medical Weblog - January 21, 2013 Category: Family Physicians Tags: News Infectious disease Obesity Source Type: blogs