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The kinetics of T regulatory cells in shock: beyond sepsisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
During the past decade, there have been an increasing number of studies investigating the precise role of T regulatory cells in human disease. First recognized for their ability to prevent autoimmunity, T regulatory cells control effector CD4+ and CD8+ T lymphocytes and innate immune cells by several different suppressive mechanisms, like cell to cell contact, secretion of inhibitory cytokines and cytolysis. This suppressive function of T regulatory cells could contribute in a similar way to the profound immune dysfunction seen in critical illness whether the latter is due to sepsis or severe injury. (Source: Critical Care)
Source: Critical Care - March 19, 2010 Category: Intensive Care Authors: Eirini ChristakiEleni Patrozou Source Type: journals

Non-invasive ventilation in acute respiratory failure related to 2009 pandemic Influenza A/H1N1 virus infectionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Noninvasive ventilation (NIV) is considered first-line intervention for different causes of acute respiratory failure (ARF). (Source: Critical Care)
Source: Critical Care - March 19, 2010 Category: Intensive Care Authors: João Carlos Winck Source Type: journals

Impact of simulation-based learning on medication error rates in critically ill patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Simulation-based learning provides a significant advantage to patient care through the reduction of medication administration errors compared to lecture style education. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-010-1860-2Authors Daniel G. Ford, Fairfield Department of Pharmacy, NorthBay Medical Center 1200 B. Gale Wilson Blvd Fairfield CA 94533 USAAmy L. Seybert, University of Pittsburgh School of Pharmacy 200 Lothrop Street Suite 302 Pittsburgh PA 15213 USAPamela L. Smithburger, University of Pittsburgh School of Pharmacy 200 Lothrop Street Suite 302 Pittsburgh PA ...
Source: Intensive Care Medicine - March 18, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Algorithmen zur Abklärung von Bewusstseinsstörungen in der Notaufnahmeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Zusammenfassung  Patienten, die wegen einer Bewusstseinsstörung in der Notaufnahme vorstellig werden, sind akut gefährdet. Ziel der ärztlichen Tätigkeit ist es, die Ursache der Bewusstseinsstörung rasch zu erkennen und eine zeitnahe Therapie einzuleiten. Das Management einer Bewusstseinsstörung ist vielschichtig und deshalb insbesondere in der Notaufnahme schwierig. In dieser Übersichtsarbeit wird ein Algorithmus vorgestellt, in dem die rasche Diagnostik und sofortige Therapie im Vordergrund stehen. Dies umfasst neben einer empirischen Erstdiagnostik und -therapie das systematische Herangehen bei der D...
Source: Intensivmedizin und Notfallmedizin - March 18, 2010 Category: Intensive Care Tags: Intensivmedizin und Notfallmedizin Source Type: journals

The Chiu/Park scale for grading intestinal ischemia–reperfusion: if it ain’t broke don’t fix it!email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-010-1811-yAuthors Mihai Oltean, The Institute for Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg Department of Surgery and Transplantation Gothenburg SwedenMichael Olausson, The Institute for Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg Department of Surgery and Transplantation Gothenburg Sweden Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - March 18, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Reply to Oltean and Olaussonemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-010-1813-9Authors Ke Xuan Liu, The First Affiliated Hospital, Sun Yat-Sen University Department of Anesthesiology 58 Zhongshan 2 Road Guangzhou 510080 Guangdong ChinaYun Sheng Li, The First Affiliated Hospital, Sun Yat-Sen University Department of Anesthesiology 58 Zhongshan 2 Road Guangzhou 510080 Guangdong ChinaWen Qi Huang, The First Affiliated Hospital, Sun Yat-Sen University Department of Anesthesiology 58 Zhongshan 2 Road Guangzhou 510080 Guangdong ChinaShu Qin Chen, The First Affiliated Hospital, Sun Yat-Sen University Department of Anesthesio...
Source: Intensive Care Medicine - March 18, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Bolus remifentanil for chest drain removal in ICU: a randomized double-blind comparison of three modes of analgesia in post-cardiac surgical patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Bolus remifentanil at the tested doses delivers excellent analgesia, but 1 μg/kg remifentanil results in respiratory depression. Remifentanil bolus at 0.5 μg/kg is safe and effective for chest drain removal after heart surgery in ICU. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-010-1836-2Authors Eoin Casey, Mater Misericordiae University Hospital Department of Anaesthesia and Critical Care Medicine Dublin IrelandAoife Lane, Mater Misericordiae University Hospital Department of Anaesthesia and Critical Care Medicine Dublin IrelandDinesh Kuriakose, Mater Mise...
Source: Intensive Care Medicine - March 18, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Effectiveness of simple daily sensitization of physicians to the duration of central venous and urinary tract catheterizationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  A simple daily reminder to physicians on the patients’ care sheets decreased the duration of central venous and urinary tract catheterization, and tended to decrease CVC infection rate without affecting UTC infection. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-010-1829-1Authors Philippe Seguin, Université Rennes 1, Hôpital de Pontchaillou Service de Réanimation Chirurgicale, INSERM U991 2, Rue Henri le Guilloux 35033 Rennes Cedex 9 FranceBruno Laviolle, Université Rennes 1, Hôpital de Pontchaillou Service de Pharmacologie et Centre d’Investigation Clinique, I...
Source: Intensive Care Medicine - March 18, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

A European care bundle for prevention of ventilator-associated pneumoniaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Adoption of these care bundles should rationalise VAP prevention practises and improve outcomes, such as length of stay. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-010-1841-5Authors Jordi Rello, Vall d’Hebrón University Hospital, Institut de Recerca Vall d’Hebrón-UAB, CIBERES Critical Care Department Barcelona SpainHartmut Lode, Academic Teaching Hospital of Charite Department of Chest and Infectious Diseases, Heliosklinikum Emil van Behring Berlin GermanyGiuseppe Cornaglia, University of Verona Department of Pathology Verona ItalyRobert Masterton, Ayrshire and Arra...
Source: Intensive Care Medicine - March 18, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

SDD, SOD, or oropharyngeal chlorhexidine to prevent pneumonia and to reduce mortality in ventilated patients: which manoeuvre is evidence-based?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-010-1809-5Authors Luciano Silvestri, Presidio Ospedaliero di Gorizia Unit of Anesthesia and Intensive Care, Department of Emergency Via Fatebenefratelli 34 34170 Gorizia ItalyHendrick K. F. van Saene, University of Liverpool School of Clinical Sciences Liverpool UKDurk F. Zandstra, Onze Lieve Vrouwe Gasthuis Intensive Care Unit Amsterdam The NetherlandsMarino Viviani, Cattinara Hospital Department of Anaesthesia, Intensive Care and Emergency Trieste ItalyDario Gregori, University of Padova Department of Environmental Medicine and Public Health Padua ...
Source: Intensive Care Medicine - March 18, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Post-intubation laryngeal injuries and extubation failure: a fiberoptic endoscopic studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  This study found a high frequency of laryngeal injuries after extubation in ICU, which were associated with intubation duration and patient’s height/ETT size ratio. Edema was not the only injury responsible for PES, and although edema is frequent it is not the only injury associated with reintubation. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-010-1847-zAuthors Jean-Marc Tadié, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou Service de Réanimation Médicale 20-40, rue Leblanc 75908 Paris Cedex 15 FranceEva Behm, Assistance Publique-Hôp...
Source: Intensive Care Medicine - March 18, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Steroids for post extubation stridor: pediatric evidence is still inconclusiveemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-010-1805-9Authors Robinder G. Khemani, Children’s Hospital Los Angeles-Anesthesia and Critical Care Medicine 4650 Sunset Blvd Mailstop 12 Los Angeles 90027 USAAdrienne Randolph, Children’s Hospital Boston-Anesthesia, Perioperative and Pain Medicine Boston Massachusetts USABarry Markovitz, Children’s Hospital Los Angeles-Anesthesia and Critical Care Medicine 4650 Sunset Blvd Mailstop 12 Los Angeles 90027 USA Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - March 18, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Critically ill infants and children with influenza A (H1N1) in pediatric intensive care units in Argentinaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  In children with ARDS, H1N1 as an etiologic agent confers high mortality, and the presence of CCCs in such patients increases the risk of death. Content Type Journal ArticleCategory Pediatric OriginalDOI 10.1007/s00134-010-1853-1Authors Julio A. Farias, Hospital de Niños R Gutiérrez Unidad de Cuidados Intensivos Pediátricos Gallo 1330 CABA 1425 Buenos Aires ArgentinaAnalía Fernández, Hospital de Niños R Gutiérrez Unidad de Cuidados Intensivos Pediátricos Gallo 1330 CABA 1425 Buenos Aires ArgentinaEzequiel Monteverde, Hospital de Niños R Gutiérrez Unidad de Cuidados Intensivos Pe...
Source: Intensive Care Medicine - March 18, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Terlipressin versus adrenaline in an infant animal model of asphyxial cardiac arrestemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  In this infant animal model of cardiac arrest, there was a non-significant trend towards better outcome when terlipressin was combined with adrenaline compared with the use of adrenaline or terlipressin alone. Content Type Journal ArticleCategory ExperimentalDOI 10.1007/s00134-010-1828-2Authors Jesús López-Herce, Hospital General Universitario Gregorio Marañón Pediatric Intensive Care Service Dr Castelo 47 28009 Madrid SpainBárbara Fernández, Hospital General Universitario Gregorio Marañón Pediatric Intensive Care Service Dr Castelo 47 28009 Madrid SpainJavier Urbano, Hospital Gene...
Source: Intensive Care Medicine - March 18, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Genetic polymorphisms in the endotoxin receptor may influence platelet count as part of the acute phase response in critically ill childrenemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Our results show that TLR4 variant alleles are associated with lower platelet counts across a range of ages and precipitating insults but that they do not influence the incidence of SIRS. This result may reflect redundancy and ‘robustness’ in the pathways leading to SIRS or the lack of specificity of this endpoint. Platelet count may vary with TLR4 genotype because it may be sufficiently sensitive and more linearly related to inflammation than other markers or, alternatively, there may be a direct TLR4-mediated platelet effect. Content Type Journal ArticleCategory Pediatric OriginalD...
Source: Intensive Care Medicine - March 18, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Clinical course and mortality risk factors in critically ill children requiring continuous renal replacement therapyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Mortality in children who require CRRT is high. Haemodynamic disturbances and the presence of multiorgan failure at the time of starting the technique are the factors associated with a higher mortality. The clinical severity scores underestimate mortality in children requiring CRRT. Content Type Journal ArticleCategory Pediatric OriginalDOI 10.1007/s00134-010-1858-9Authors Maria J. Santiago, Hospital General Universitario Gregorio Marañón Pediatric Intensive Care Service Dr Castelo 47 28009 Madrid SpainJesús López-Herce, Hospital General Universitario Gregorio Marañón Pediatric Int...
Source: Intensive Care Medicine - March 18, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Effects of preserved spontaneous breathing activity during mechanical ventilation in experimental intra-abdominal hypertensionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  In the presence of severe intra-abdominal hypertension, the addition of unsupported spontaneous breaths to BIPAP did not improve hemodynamic and respiratory function and caused greater histopathologic damage to the lungs. Content Type Journal ArticleCategory ExperimentalDOI 10.1007/s00134-010-1827-3Authors Dietrich Henzler, University Hospital, RWTH Aachen Department of Anesthesiology Aachen GermanyNadine Hochhausen, University Hospital, RWTH Aachen Department of Anesthesiology Aachen GermanyRalf Bensberg, University Hospital, RWTH Aachen Department of Anesthesiology Aachen GermanyAlexand...
Source: Intensive Care Medicine - March 18, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Enoxaparin - effective dosage for intensive care patients: double-blinded, randomised clinical trialemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: Our study confirmed that a standard dose of 40 mg enoxaparin yielded sub- therapeutic levels of aFXa in critically ill patients. Higher doses resulted in better peak aFXa levels, with a ceiling effect observed at 60 mg. The present study seems to suggest inadequate dosage as one of the possible mechanisms for the higher failure rate of enoxaparin in ICU patients.Trial Registration: ISRCTN03037804 (Source: Critical Care)
Source: Critical Care - March 18, 2010 Category: Intensive Care Authors: Sian RobinsonAleksander ZincukThomas StromTorben Bjerregaard LarsenBjarne RasmussenPalle Toft Source Type: journals

Mechanical ventilation with high tidal volume induces inflammation in patients without lung diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: The use of lower tidal volumes may limit pulmonary inflammation in mechanically ventilated patients even without lung injury.Clinical Trial registration: NCT00935896 (Source: Critical Care)
Source: Critical Care - March 18, 2010 Category: Intensive Care Authors: Roselaine OliveiraMarcio HetzelMauro SilvaDaniele DallegraveGilberto Friedman Source Type: journals

Resuscitation with low volume hydroxyethylstarch 130kDa/0.4 is not associated with acute kidney injuryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: Volume expansion with low volume HES 130kDa/0.4 was not associated with AKI. (Source: Critical Care)
Source: Critical Care - March 18, 2010 Category: Intensive Care Authors: Nicolas BoussekeyRaphael DarmonJoachim LangloisSerge AlfandariPatrick DevosAgnes MeybeckArnaud ChicheHugues GeorgesOlivier Leroy Source Type: journals

Cardiopulmonary Bypassemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
No description available (Source: Critical Care)
Source: Critical Care - March 18, 2010 Category: Intensive Care Authors: Luc RondelezPhilippe Van der Linden Source Type: journals

Authors' replyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Singh Harsimran, Tewari Anurag, Kaur Balvinder, Garg SuchitaIndian Journal of Critical Care Medicine 2009 13(4):225-225 (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - March 17, 2010 Category: Intensive Care Authors: Singh Harsimran, Tewari Anurag, Kaur Balvinder, Garg Suchita Source Type: journals

Venous air embolismemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Aggarwal SourabhIndian Journal of Critical Care Medicine 2009 13(4):225-225 (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - March 17, 2010 Category: Intensive Care Authors: Aggarwal Sourabh Source Type: journals

Patient communication (SMS) in ICUemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Haranath P. S. R. KIndian Journal of Critical Care Medicine 2009 13(4):224-225 (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - March 17, 2010 Category: Intensive Care Authors: Haranath P. S. R. K Source Type: journals

Anaphylactoid to polyurethane foam (yellow foam) among architectsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Wiwanitkit VirojIndian Journal of Critical Care Medicine 2009 13(4):224-224 (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - March 17, 2010 Category: Intensive Care Authors: Wiwanitkit Viroj Source Type: journals

Acute renal failure caused by pheniramine maleate induced rhabdomyolysis: An unusual caseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report a case of a suicide attempt in a young male, where ingestion of antihistamine pheniramine maleate was complicated by nontraumatic rhabdomyolysis and oliguric acute renal failure. Rhabdomyolysis and acute renal failure is a rarely reported but potentially serious complication among patients who present to the emergency after intentional overdoses making recognition and prompt intervention essential. We also describe the potential mechanism of muscle injury in antihistamine overdose. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - March 17, 2010 Category: Intensive Care Authors: Paul G, Sood P, Paul B S, Puri S Source Type: journals

Extreme metabolic alkalosis in intensive careemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Tripathy SwagataIndian Journal of Critical Care Medicine 2009 13(4):217-220Metabolic alkalosis is a commonly seen imbalance in the intensive care unit (ICU). Extreme metabolic alkalemia, however, is less common. A pH greater than 7.65 may carry a high risk of mortality (up to 80%). We discuss the entity of life threatening metabolic alkalemia by means of two illustrative cases - both with a pH greater than 7.65 on presentation. The cause, modalities of managing and complications of this condition is discussed from the point of view of both the traditional method of Henderson and Hasselbalch and the mathematical mode...
Source: Indian Journal of Critical Care Medicine - March 17, 2010 Category: Intensive Care Authors: Tripathy Swagata Source Type: journals

Ultrasonography: A novel approach to central venous cannulationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: USG-guided CVC is thus easier, quicker, and safer than landmark approach. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - March 17, 2010 Category: Intensive Care Authors: Agarwal Ankit, Singh Dinesh K, Singh Anil P Source Type: journals

Role of noninvasive ventilation in weaning from mechanical ventilation in patients of chronic obstructive pulmonary disease: An Indian experienceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Prasad Shiva B.N, Chaudhry Dhruva, Khanna RajanIndian Journal of Critical Care Medicine 2009 13(4):207-212Background: Endotracheal intubation and mechanical ventilation (MV) are often needed in patients of chronic obstructive pulmonary disease (COPD) with acute hypercapnic respiratory failure. The rate of weaning failure is high and prolonged MV increases intubation associated complications. Objective: To evaluate the role of Noninvasive ventilation (NIV) in weaning patients of chronic obstructive pulmonary disease (COPD) from MV, after T piece trial failure. Design: A prospective, randomized, controlled study was conducte...
Source: Indian Journal of Critical Care Medicine - March 17, 2010 Category: Intensive Care Authors: Prasad Shiva B.N, Chaudhry Dhruva, Khanna Rajan Source Type: journals

Quality indicators for ICU: ISCCM guidelines for ICUs in Indiaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Ray B, Samaddar D P, Todi S K, Ramakrishnan N, John George, Ramasubban SureshIndian Journal of Critical Care Medicine 2009 13(4):173-206 (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - March 17, 2010 Category: Intensive Care Authors: Ray B, Samaddar D P, Todi S K, Ramakrishnan N, John George, Ramasubban Suresh Source Type: journals

Non-invasive ventilation for critically ill patients with Pandemic H1N1 2009 Influenza A Virus infection.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
N/A (Source: Critical Care)
Source: Critical Care - March 17, 2010 Category: Intensive Care Authors: SILVIO ÑAMENDYS-SILVAMARISOL HERNANDEZ-GARAYEDUARDO RIVERO-SIGARROA Source Type: journals

Attributable mortality of ventilator-associated pneumonia: respective impact of main characteristics at ICU admission and VAP onset using conditional logistic regression and multi-state modelsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  A multistate model that appropriately handled VAP as a time-dependent event produced lower VAP-AM values than conditional logistic regression. VAP-AM varied widely with case-mix. Disease severity at VAP onset markedly influenced VAP-AM; this may contribute to the variability of previous estimates. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-010-1824-6Authors Molière Nguile-Makao, University Grenoble 1, Albert Bonniot Institute INSERM U823 Grenoble FranceJean-Ralph Zahar, University Grenoble 1, Albert Bonniot Institute INSERM U823 Grenoble FranceAdrien Français, Unive...
Source: Intensive Care Medicine - March 16, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Regional lung aeration and ventilation during pressure support and biphasic positive airway pressure ventilation in experimental lung injuryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: In this model of ALI, the reduction of tidal re-aeration and hyperaeration during BIPAP+SBmean compared to PSV is not due to decreased nonaerated areas at end-expiration or different distribution of ventilation, but to lower tidal volumes during BIPAP+SBspont. The ratio between spontaneous to controlled breaths seems to play a pivotal role in reducing tidal re-aeration and hyperaeration during BIPAP+SBmean. (Source: Critical Care)
Source: Critical Care - March 16, 2010 Category: Intensive Care Authors: Marcelo Gama de AbreuMaximiliano CuevasPeter SpiethAlysson CarvalhoVolker HietscholdChristian StroszczynskiBarbel WiedemannThea KochPaolo PelosiEdmund Koch Source Type: journals

Eicosapentaenoic acid preserves diaphragm force generation following endotoxin administrationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study examined the effect of eicosapentaenoic acid (EPA), an immunomodulator that can be safely administered to patients, on diaphragm force generation following endotoxin administration. Methods: Rats were administered the following (n=5/group): (a) saline, (b) endotoxin, 12 mg/kg IP, (c) endotoxin + EPA (1.0 g/kg/d), and (d) EPA alone. Diaphragms were removed and measurements made of the diaphragm force-frequency curve, calpain activation, caspase activation, and protein carbonyl levels. Results: Endotoxin elicited large reductions in diaphragm specific force generation (p (Source: Critical Care)
Source: Critical Care - March 16, 2010 Category: Intensive Care Authors: Gerald SupinskiJonas VanagsLeigh Ann Callahan Source Type: journals

Alveolar fluid clearance in healthy pigs and influence of positive end-expiratory pressureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The objectives were to characterize alveolar fluid clearance (AFC) in pigs with normal lungs and to analyze the effect of immediate application of positive end-expiratory pressure (PEEP). Methods: Animals (n=25) were mechanically ventilated and divided into four groups: small edema (SE) group, producing pulmonary edema (PE) by intratracheal instillation of 4 ml/kg of saline solution; small edema with PEEP (SE+PEEP) group, same as previous but applying PEEP of 10 cmH2O; large edema (LE) group, producing PE by instillation of 10 ml/kg of saline solution; large edema with PEEP (LE+PEEP) group, same as LE group but applying PE...
Source: Critical Care - March 16, 2010 Category: Intensive Care Authors: Manuel Garcia-DelgadoAngel Touma-FernandezVirginia Chamorro-MarinAntonio Ruiz-AguilarEduardo Aguilar-AlonsoEnrique Fernandez-Mondejar Source Type: journals

Accuracy of C-reactive protein, procalcitonin, and mid-regional pro-atrial natriuretic peptide to guide site of care of community-acquired pneumoniaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  In a selected population of CAP with low risk of complication, a single ANP measurement was more accurate than CRP and PCT to predict appropriate admission. These results should be confirmed by additional studies. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-010-1818-4Authors Yann-Erick Claessens, Hôpital Cochin, APHP Department of Emergency Medicine 27 rue du Faubourg Saint-Jacques 75679 Paris Cedex 14 FranceThierry Mathevon, Hôpital Gabriel Montpied Department of Emergency Medicine 58 rue Montalembert 63003 Clermont-Ferrand Cedex 1 FranceGérald Kierzek, Hôpital H...
Source: Intensive Care Medicine - March 15, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Comparison of high-frequency oscillation and tracheal gas insufflation versus standard high-frequency oscillation at two levels of tracheal pressureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  At the same P tr level, HFO-TGI results in superior gas exchange compared with HFO. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-010-1822-8Authors Spyros D. Mentzelopoulos, University of Athens Medical School First Department of Intensive Care Medicine Athens GreeceSotiris Malachias, University of Athens Medical School First Department of Intensive Care Medicine Athens GreeceStelios Kokkoris, University of Athens Medical School First Department of Intensive Care Medicine Athens GreeceCharis Roussos, University of Athens Medical School First Department of Intensive Care ...
Source: Intensive Care Medicine - March 15, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Gastric residual volume during enteral nutrition in ICU patients: the REGANE studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Diet volume ratio of mechanically ventilated patients treated with enteral nutrition is not affected by increasing the limit in GRV. A limit of 500 ml is not associated with adverse effects in gastrointestinal complications or in outcome variables. A value of 500 ml can be equally recommended as a normal limit for GRV. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-010-1856-yAuthors J. C. Montejo, Hospital Universitario 12 de Octubre Medicina Intensiva, Unidad Polivalente, ICU Glorieta de Málaga s/n 28041 Madrid SpainE. Miñambres, Hospital Universitario Marqu...
Source: Intensive Care Medicine - March 15, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Impact of body mass on incidence and prognosis of acute kidney injury requiring renal replacement therapyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Obesity is an independent risk factor for developing AKI. Our results provide further evidence that body mass impacts on survival of patients with AKI requiring renal replacement therapy. Obese patients seem to have a survival benefit compared to underweight or normal weight patients. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-010-1844-2Authors Wilfred Druml, Medical University of Vienna Division of Nephrology, Department of Internal Medicine III Vienna AustriaBarbara Metnitz, Medical University of Vienna Department of Medical Statistics Vienna AustriaEva Schaden, Me...
Source: Intensive Care Medicine - March 15, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

The effect of endotracheal suction on regional tidal ventilation and end-expiratory lung volumeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  ETT suction causes transient loss of EELV and V T throughout the lung. Catheter size exerts a greater influence than suction method, with CS only protecting against derecruitment when a small catheter is used, especially in the non-dependent lung. Content Type Journal ArticleCategory ExperimentalDOI 10.1007/s00134-010-1849-xAuthors D. G. Tingay, Royal Children’s Hospital Department of Neonatology Flemington Rd. Melbourne VIC 3052 AustraliaB. Copnell, Royal Children’s Hospital Department of Neonatology Flemington Rd. Melbourne VIC 3052 AustraliaC. A. Grant, Mater Children’s Hospital...
Source: Intensive Care Medicine - March 15, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Individual patient data meta-analysis in intensive care medicine and contextual effectsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-010-1812-xAuthors James C. Hurley, University of Melbourne School of Rural Health Melbourne VIC Australia Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - March 15, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Tracheal pressure and endotracheal tube obstruction can be detected by continuous cuff pressure monitoring: in vitro pilot studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  This study proposes a new method to predict the degree of ETT obstruction based on differences between P c and P v. The method was proved accurate on simulator, and further studies are needed on intubated patients. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-010-1835-3Authors Shai Efrati, Tel-Aviv University Research and Development Unit, Assaf Harofeh Medical Center, Zerifin, affiliated with the Sackler School of Medicine Zerifin IsraelIsrael Deutsch, Tel-Aviv University Research and Development Unit, Assaf Harofeh Medical Center, Zerifin, affiliated with the Sackler...
Source: Intensive Care Medicine - March 15, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Diagnostic utility of elevated serum soluble triggering receptor expressed on myeloid cells (sTREM)-1 in infected neonatesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Serum sTREM-1 increases in infected neonates. Diagnostic accuracy of sTREM-1 either alone or in combination with IL-6 is not better than that of IL-6. Content Type Journal ArticleCategory Pediatric Brief ReportDOI 10.1007/s00134-010-1819-3Authors Kosmas Sarafidis, University of Thessaloniki, “Hippokration” General Hospital 1st Department of Neonatology of Aristotle Kostantinoupoleos 49 54642 Thessaloniki GreeceVasiliki Soubasi-Griva, University of Thessaloniki, “Hippokration” General Hospital 1st Department of Neonatology of Aristotle Kostantinoupoleos 49 54642 Thessaloniki Greece...
Source: Intensive Care Medicine - March 15, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Imminent brain death: point of departure for potential heart-beating organ donor recognitionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  The definition of imminent brain death can be used as a point of departure for potential heart-beating organ donor recognition on the intensive care unit or retrospective medical chart analysis. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-010-1848-yAuthors Yorick J. de Groot, Erasmus MC University Medical Center Rotterdam Department of Intensive Care P.O. Box 2040 3000 CA Rotterdam The NetherlandsNichon E. Jansen, Dutch Transplant Foundation Leiden The NetherlandsJan Bakker, Erasmus MC University Medical Center Rotterdam Department of Intensive Care P.O. Box 2040 3000 C...
Source: Intensive Care Medicine - March 15, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Do soluble mediators cause ventilator-induced lung injury and multi-organ failure?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Adaptation of Koch’s postulates to the biotrauma hypothesis of VALI could provide important insights. Translation of the acquired knowledge into clinical testing is challenged by the heterogeneity of the patient population (e.g., etiology, co-morbidity, genetics or concomitant therapy) and the specificity and efficacy of the therapeutic intervention on the cellular/molecular level. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00134-010-1850-4Authors Thomas Jaecklin, University of Toronto Physiology and Experimental Medicine Program, Hospital for Sick Children Toronto Canada...
Source: Intensive Care Medicine - March 15, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Surfactant use based on the oxygenation response to lung recruitment during HFOV in VLBW infantsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  First intention HFOV combined with an early attempt at lung volume optimization might allow surfactants to be used more selectively (in relation to disease severity) in VLBW infants presenting with RDS at birth without negatively influencing the outcome. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-010-1838-0Authors Pierre Tissières, University Hospital of Geneva Division of Pediatric and Neonatal Intensive Care, Department of Pediatrics 6, Rue Willy Donzé 1211 Geneva 14 SwitzerlandPatrick Myers, University Hospital of Geneva Division of Pediatric and Neonatal Intensi...
Source: Intensive Care Medicine - March 15, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Correction to “Detection of architectural distortion in prior mammograms using Gabor filters, phase portraits, fractal dimension, and texture analysis [1]”email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s11548-010-0408-9Authors Shantanu Banik, University of Calgary Department of Electrical and Computer Engineering, Schulich School of Engineering Calgary AB T2N 1N4 CanadaRangaraj M. Rangayyan, University of Calgary Department of Electrical and Computer Engineering, Schulich School of Engineering Calgary AB T2N 1N4 Canada Journal International Journal of Computer Assisted Radiology and SurgeryOnline ISSN 1861-6429Print ISSN 1861-6410 (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - March 15, 2010 Category: Intensive Care Tags: International Journal of Computer Assisted Radiology and Surgery Source Type: journals

Endocardial boundary extraction in left ventricular echocardiographic images using fast and adaptive B-spline snake algorithmemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  In sum, the proposed method achieves satisfactory results with low computational complexity. This algorithm provides a robust and feasible technique for echocardiographic image segmentation. Suggestions for future improvements of the method are provided. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11548-010-0404-0Authors Mahdi Marsousi, K.N. Toosi University of Technology Tehran IranArmin Eftekhari, Colorado School of Mines Golden USAArmen Kocharian, Tehran University Tehran IranJavad Alirezaie, Ryerson University Toronto Canada Journal International Journal of...
Source: International Journal of Computer Assisted Radiology and Surgery - March 15, 2010 Category: Intensive Care Tags: International Journal of Computer Assisted Radiology and Surgery Source Type: journals

Reply to Hurleyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-010-1817-5Authors Michael C. Reade, University of Melbourne Intensive Care Medicine Melbourne AustraliaDonald M. Yealy, University of Pittsburgh Emergency Medicine Pittsburgh USAMichael J. Bailey, Monash University Australian and New Zealand Intensive Care Research Centre Melbourne Australia Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - March 15, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Age-dependent effects of gradual decreases in cerebral perfusion pressure on the neurochemical response in swineemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  The lower limit of CBF autoregulation was associated with modifications in neurochemical parameters that clearly occurred before brain oxidative metabolism was compromised. Early indicators for mild to moderate hypoperfusion are elevated levels of lactate and dopamine, but elevated levels of glutamate appear to be an indicator of brain ischemia. The shift to the left of the lower autoregulatory threshold is mainly responsible for the postponed neurochemical response to decrements in the CPP in the immature brain. Content Type Journal ArticleCategory ExperimentalDOI 10.1007/s00134-010-184...
Source: Intensive Care Medicine - March 15, 2010 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals