Intensive CareThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory.

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Effects of unilateral decompressive craniectomy on patients with unilateral acute post-traumatic brain swelling after severe traumatic brain injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data suggest that unilateral DC has superiority in lowering ICP, reducing the mortality rate and improving neurological outcomes over unilateral routine temporoparietal craniectomy. However, it increases the incidence of delayed intracranial hematomas and subdural effusion, some of which need secondary surgical intervention. These results provide information important for further large and multicenter clinical trials on the effects of DC in patients with acute post-traumatic BS.Trial registration: ISRCTN14110527 (Source: Critical Care)
Source: Critical Care - November 20, 2009 Category: Intensive Care Authors: Wusi QiuChenchen GuoHong ShenKeyong ChenLiang WenHongjie HuangMin DingLi SunQizhou JiangWeiming Wang Source Type: journals

England Sees Improvement After Investing in ICU ChangesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Survival rates of patients in intensive care have jumped in England since the government boosted spending and reformed critical care services, according to a study published in the British Medical Journal. The Department of Health invested £300 million in 2000 to help fund a 35% increase in beds as well as to implement outreach services and adopt clinical guidelines. The move cut the risk of mortality in critical care units by 11.3% and reduced hospital mortality rates by 13.4%. The cost effectiveness of critical care also increased after 2000, partly as a result of outcomes improvements and smaller increases in the a...
Source: SCCM RSS News - November 19, 2009 Category: Intensive Care Source Type: news

Your Colleagues Are Seeking ProtocolsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion topics include Adult Critical Care, Pediatric Critical Care and Protocols... (Source: SCCM RSS News)
Source: SCCM RSS News - November 19, 2009 Category: Intensive Care Source Type: news

Make a Sweet Escape: Attend the Post-Congress ConferenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Enjoy an extended Congress by attending the Post-Congress Conference, Hyperglycemia and Critical Illness: Adaptive Response or Therapeutic Opportunity?, to be held in Key West, Florida, USA. A faculty of international experts will present a pro/con debate on the Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE-SUGAR) Study. The meeting also will feature case studies on insulin protocols and nutritional guidelines as well as interactive debates on glucose variability and achieving glycemic control. Audience participation will be encouraged to enhance the overall learning expe...
Source: SCCM RSS News - November 19, 2009 Category: Intensive Care Source Type: news

Experience the Complete Congress PackageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pre-register for the Society of Critical Care Medicine’s (SCCM) 39th Critical Care Congress by December 10, 2009. The five continuous days of educational sessions, hands-on workshops, interactive debates, and networking opportunities will provide you with effective solutions to the everyday challenges facing you and your team... (Source: SCCM RSS News)
Source: SCCM RSS News - November 19, 2009 Category: Intensive Care Source Type: news

AMA House of Delegates Address EOL, Healthcare ReformEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The American Medical Association’s House of Delegates last week met for its interim meeting to discuss the ongoing healthcare system debate. Representatives from the Society of Critical Care Medicine attended the meeting, where AMA President J. James Rohack, MD, reiterated the group’s support for the latest bills making their way through Congress, the Affordable Health Care for America Act and the Medicare Physician Payment Reform Act of 2009. Rohack noted the perceived shortcomings of the Affordable Health Care for America Act, namely its lack of coverage for everyone and concerns about access. He stressed that ...
Source: SCCM RSS News - November 19, 2009 Category: Intensive Care Source Type: news

ISCCM Preparing a New Critical Care WorkforceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Nagpur chapter of the Indian Society of Critical Care Medicine (ISCCM) recently was featured in the The Times of India for the group’s efforts to launch a new, hands-on critical care training program for resident and junior physicians, nurses and other members of the multiprofessional team. For many, this will be their first exposure to such training, as critical care management courses usually are not included in the Indian curriculum at the undergraduate or postgraduate levels... (Source: SCCM RSS News)
Source: SCCM RSS News - November 19, 2009 Category: Intensive Care Source Type: news

Get the First Articles from CCM's H1N1 SupplementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A supplement to Critical Care Medicine focused on H1N1 influenza will be released next year, but open-access article proofs are being posted online as they become available, ensuring clinicians receive this information as soon as possible. Read the first supplement article available, "Infection control in mass respiratory failure: Preparing to respond to H1N1."... (Source: SCCM RSS News)
Source: SCCM RSS News - November 19, 2009 Category: Intensive Care Source Type: news

Study Investigates New Pulmonary Embolism ThrombolysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers at Stanford have shown catheter-directed thrombolysis to be an effective procedure in first-line treatment for pulmonary embolism (PE). A meta-analysis published in the Journal of Vascular and Interventional Radiology found that, between 1990 and 2008, the procedure was successful in 86.5% of 594 patients who were at risk of dying of PE. Catheter-directed thrombolysis appeared effective and safer than injecting the high-dose thrombolytic drug into the bloodstream, which can cause bleeding in up to 20% of patients. By targeting blood clots directly, the catheter-based procedure was associated with only a 2.4% ch...
Source: SCCM RSS News - November 19, 2009 Category: Intensive Care Source Type: news

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Critical Care)
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Tags: Frontmatter Source Type: journals

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Critical Care)
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Tags: Frontmatter Source Type: journals

Ranitidine is unable to maintain gastric pH levels above 4 in septic patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Intravenous ranitidine was unable to maintain gastric pH above 4 in septic patients. All cases in the ranitidine group in whom pH remained above 4 had gastric hypotrophy or atrophy. Pantoprazole successfully maintained pH levels above 4. (Source: Journal of Critical Care)
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Authors: Cristina B. Terzi Coelho, Desanka Dragosavac, João S. Coelho Neto, Ciro G. Montes, Fábio Guerrazzi, Nelson Adami Andreollo Tags: Electronic Articles Source Type: journals

Reviewers 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Critical Care)
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Authors: Michelle Rizoli Source Type: journals

Retractions: Guidance from the Committee on Publication EthicsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal editors should consider retracting a publication if: They have clear evidence that the findings are unreliable, either as a result of misconduct (eg, data fabrication) or honest error (eg, miscalculation or experimental error) (Source: Journal of Critical Care)
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Authors: Elizabeth Wager, Virginia Barbour, Steven Yentis, Sabine Kleinert, on behalf of COPE Council Source Type: journals

Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors of this book have taken it upon themselves to present many of the controversial issues that physicians treating the critically ill patient are often faced with. The sections are nicely organized by organ systems and address topics including support of failing organ systems, ventilator management, fluid resuscitation, and sepsis. More recent topics, such as tight glucose control and end-of-life issues, are discussed. Chapters are included on organizational, technological, and ethical considerations. Each chapter has been written by internationally renowned experts in their area and is presented in a clear, conci...
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Authors: Peter Roffey Tags: Book Review Source Type: journals

Effects of propofol and dexmedetomidine on indocyanine green elimination assessed with LİMON to patients with early septic shock: A pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In our study, we found that neither propofol nor dexmedetomidine infusion affected hepatic blood flow. (Source: Journal of Critical Care)
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Authors: Dilek Memiş, M. Kargi, N. Sut Tags: Sepsis/Infection Source Type: journals

World Federation Update: Strategic Initiatives from Florence to DurbanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The 10th Quadrennial Meeting of the World Federation of Societies of Intensive and Critical Care Medicine (WFSICCM) was held in Florence, Italy, last August 28 to September 1, 2009. Hosted by the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Therapy and led by the steering committee chaired by Luciano Gattinoni (Milan), and his associates A Raffaelo De Gaudio (Florence), Antonino Gullo (Catania), and Rosalba Tufano (Naples), the delegates represented 96 countries and numbered more than 2000. The meeting was co-sponsored by the World Federation of Critical Care Nurses and the World Federation of Pedi...
Source: Journal of Critical Care - November 19, 2009 Category: Intensive Care Authors: Philip D. Lumb Tags: Editorial Source Type: journals

Neuroimaging in the Medical Intensive Care Unit: An Essential Complement to the Clinical ExaminationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Intensive Care Medicine)
Source: Journal of Intensive Care Medicine - November 19, 2009 Category: Intensive Care Authors: Lee, K., Badjatia, N. Tags: Articles Source Type: journals

Respect for Persons: Beyond the Mortal WorldEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Intensive Care Medicine)
Source: Journal of Intensive Care Medicine - November 19, 2009 Category: Intensive Care Authors: Bierer, G. Tags: Articles Source Type: journals

Circulatory Arrest in a Brain-Dead Organ Donor: Is the Use of Cardiac Compression Permissible?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Care of the brain-dead patient is common in intensive care practice. Aggressive donor management is advocated to increase supply of viable organs. Significant controversy exists over cardiac resuscitation in patients determined dead by cardiac criteria. The issue, till now, has not been addressed in brain dead patients. We discuss a case of cardiac resuscitation of a brain-dead donor to ensure organ donation. This case allows us to examine the use of brain death criteria to declare death, the controversy regarding cardiac resuscitation in organ donor patients, and the standards for use of cardiac resuscitation in the organ...
Source: Journal of Intensive Care Medicine - November 19, 2009 Category: Intensive Care Authors: Cummings, B., Noviski, N., Moreland, M. P., Paris, J. J. Tags: Articles Source Type: journals

Bi-Level Positive Airway Pressure Ventilation in Pediatric Oncology Patients With Acute Respiratory FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the study was to describe our experience with bi-level positive airway pressure (BiPAP) ventilation in oncology children with acute respiratory failure, hospitalized in a single tertiary pediatric tertiary center. This was a retrospective cohort study of all pediatric oncology patients in our center admitted to the intensive care unit with acute hypoxemic or hypercarbic respiratory failure from January 1999 through May 2006, who required mechanical ventilation with BiPAP. Fourteen patients met the inclusion criteria with a total of 16 events of respiratory failure or impending failure: 12 events were hypoxemic, ...
Source: Journal of Intensive Care Medicine - November 19, 2009 Category: Intensive Care Authors: Schiller, O., Schonfeld, T., Yaniv, I., Stein, J., Kadmon, G., Nahum, E. Tags: Articles Source Type: journals

Acute Hemodynamic Effects of Recruitment Maneuvers in Patients With Acute Respiratory Distress SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A transient decrease in mean BP was observed during the RM, and its degree was correlated with the preload decrease, while cardiac contractility was maintained. (Source: Journal of Intensive Care Medicine)
Source: Journal of Intensive Care Medicine - November 19, 2009 Category: Intensive Care Authors: Kwang Joo Park, , Yoon Jung Oh, , Hyuk Jae Chang, , Seung Soo Sheen, , Choi, J., Keu Sung Lee, , Joo Hun Park, , Sung Chul Hwang, Tags: Articles Source Type: journals

The Role of Head Computer Tomographic Scans on the Management of MICU Patients With Neurological DysfunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests that clinicians should have a low threshold for ordering a CT scan in MICU patients with acute neurological dysfunction. (Source: Journal of Intensive Care Medicine)
Source: Journal of Intensive Care Medicine - November 19, 2009 Category: Intensive Care Authors: Salerno, D., Marik, P. E., Daskalakis, C., Kolm, P., Leone, F. Tags: Articles Source Type: journals

Inhalational Anesthesia: Basic Pharmacology, End Organ Effects, and Applications in the Treatment of Status AsthmaticusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The potent inhalational anesthetic agents are used on a daily basis to provide intraoperative anesthesia. Given their beneficial effects on airway tone and reactivity, they also have a role in the treatment of status asthmaticus that is refractory to standard therapy. Although generally not of clinical significance, these agents can affect various physiological functions. The potent inhalational anesthetic agents decrease mean arterial pressure and myocardial contractility. The decrease in mean arterial pressure reduces renal and hepatic blood flow. Secondary effects on end-organ function may result from the metabolism of ...
Source: Journal of Intensive Care Medicine - November 19, 2009 Category: Intensive Care Authors: Tobias, J. D. Tags: Articles Source Type: journals

A Simple Physiologic Algorithm for Managing Hemodynamics Using Stroke Volume and Stroke Volume Variation: Physiologic Optimization ProgramEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intravascular volume status and volume responsiveness continue to be important questions for the management of critically ill or injured patients. Goal-directed hemodynamic therapy has been shown to be of benefit to patients with severe sepsis and septic shock, acute lung injury and adult respiratory distress syndrome, and for surgical patients in the operating room. Static measures of fluid status, central venous pressure (CVP), and pulmonary artery occlusion pressure (PAOP) are not useful in predicting volume responsiveness. Stroke volume variation and pulse pressure variation related to changes in stroke volume during p...
Source: Journal of Intensive Care Medicine - November 19, 2009 Category: Intensive Care Authors: McGee, W. T. Tags: Articles Source Type: journals

Analytic Review: Hyponatremia in Heart FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hyponatremia is one of the newer and emerging risk factors for an adverse prognosis in chronic heart failure. Why decreased serum sodium is associated with worse prognosis remains unclear. It may reflect worsening heart failure and the deleterious effects of activation of neurohormones. The mechanism of hyponatremia in heart failure also remains unclear. A relatively greater degree of free-water retention compared to sodium retention is probably the major mechanism. The treatment of significant hyponatremia in heart failure is difficult. The conventional treatments such as fluid restriction, infusion of hypertonic saline, ...
Source: Journal of Intensive Care Medicine - November 19, 2009 Category: Intensive Care Authors: Chatterjee, K. Tags: Articles Source Type: journals

Severe Influenza A (H1N1)v in patients without any known risk factorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In Rello et al work 15 out of 32 critical pandemic flu patients did not have any risk factor. A further analysis in this subgroup of patients is needed. Antiviral treatment delay or any other management event differences perhaps were responsible for progressive illness. This data may help management in initial care of pandemic flu patients. (Source: Critical Care)
Source: Critical Care - November 19, 2009 Category: Intensive Care Authors: Carles Alonso-TarresCristina Cortes-LletgetSara PintadoAssumpta Ricart Source Type: journals

Presentation and management of critically ill patients with Influenza A (H1N1) influenza - a UK perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A report of the demographics, presentation and management of patients with influenza A (H1N1) in a general adult intensive care unit in the United Kingdom. (Source: Critical Care)
Source: Critical Care - November 19, 2009 Category: Intensive Care Authors: Joyce YeungMark BaileyGavin PerkinsFang Gao Smith Source Type: journals

PTX3 as a potential biomarker of acute lung injury: supporting evidence from animal experimentationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These results support the clinical finding that PTX3 may be a useful biomarker to the reflect severity of lung injury and provide effective therapies. The interplay between PTX3 and TF could be a potential mechanism that mediates lung injury. Content Type Journal ArticleCategory ExperimentalDOI 10.1007/s00134-009-1720-0Authors Xiaolin He, University Health Network Latner Thoracic Surgery Research Laboratory, Toronto General Research Institute Toronto ON CanadaBing Han, University Health Network Latner Thoracic Surgery Research Laboratory, Toronto General Research Institute Toronto ON CanadaX...
Source: Intensive Care Medicine - November 18, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

An intervention to decrease complications related to endotracheal intubation in the intensive care unit: a prospective, multiple-center studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The implementation of an intubation management protocol can reduce immediate severe life-threatening complications associated with intubation of ICU patients. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1717-8Authors Samir Jaber, Université Montpellier 1 Intensive Care Unit, Anesthesia and Critical Care Department B: DAR B, CHU de Montpellier, Saint Eloi Teaching Hospital 80 avenue Augustin Fliche 34295 Montpellier Cedex 5 FranceBoris Jung, Université Montpellier 1 Intensive Care Unit, Anesthesia and Critical Care Department B: DAR B, CHU de Montpellier, Saint Eloi...
Source: Intensive Care Medicine - November 18, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Effects of reducing beta-lactam antibiotic pressure on intestinal colonization of antibiotic-resistant gram-negative bacteriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion A 35–39% reduction of β-lactam exposure was not associated with reduced acquisition of CRE, whereas a 243% increase of fluoroquinolone use increased acquisition of FCRE. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1714-yAuthors Saskia Nijssen, St. Elisabethziekenhuis Department of Medical Microbiology Hilvarenbeekse Weg 60 5022 GC Tilburg The NetherlandsAd Fluit, University Medical Center Utrecht Department of Medical Microbiology, Julius Center for Health Sciences and Primary Care Heidelberglaan 100 3584 CX Utrecht The NetherlandsDavid van de Vijver, Erasmus Medic...
Source: Intensive Care Medicine - November 18, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

A successful new method for removal of a large foreign body from the airways of an ARDS patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s00134-009-1716-9Authors Veronique Leray, CHU Croix Rousse Medical Intensive Care Unit 103 grande rue de la Croix Rousse 69004 Lyon FrancePascale Nesme, Hôpital de la Croix Rousse, CHU de Lyon Service de Pneumologie Lyon FranceGuillaume Landry, Hôpital de la Croix Rousse, CHU de Lyon Service de Chirurgie ORL Lyon FranceBertrand Pons, Hôpital de la Croix Rousse, CHU de Lyon Service de Réanimation Médicale Lyon FranceJean-christian Pignat, Hôpital de la Croix Rousse, CHU de Lyon Service de Chirurgie ORL Lyon FranceClaude Guerin, Hôpital de la Croix Rou...
Source: Intensive Care Medicine - November 18, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Prevention of acute kidney injury and protection of renal function in the intensive care unitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions and recommendations Several measures are recommended, though none carries grade 1A. We recommend prompt resuscitation of the circulation with special attention to providing adequate hydration whilst avoiding high-molecular-weight hydroxy-ethyl starch (HES) preparations, maintaining adequate blood pressure using vasopressors in vasodilatory shock. We suggest using vasopressors in vasodilatory hypotension, specific vasodilators under strict hemodynamic control, sodium bicarbonate for emergency procedures administering contrast media, and periprocedural hemofiltration in severe chronic renal in...
Source: Intensive Care Medicine - November 18, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Clinical guidelines for the protection of kidney function and prevention of acute kidney injury in the intensive care unit: common sense rather than magic bullets?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s00134-009-1683-1Authors Andrew Davenport, University College London Medical School UCL Center for Nephrology, Royal Free Campus Rowland Hill Street London NW3 2PF UK Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - November 18, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

SCCM Pod-119 PCCM: Does Fellowship Program Size and Rotations Affect Clinical and Research Time?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Wynne Morrison, MD, discusses an article published in the May issue of Pediatric Critical Care Medicine, which highlighted the results of a national survey of pediatric critical care medicine fellowship clinical and research time allocation. (Source: SCCM PodCast - iCritical Care)
Source: SCCM PodCast - iCritical Care - November 17, 2009 Category: Intensive Care Authors: The Society of Critical Care Medicine (SCCM) Tags: Health Source Type: podcasts

The leading causes of death after burn injury in a single pediatric burn centerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
IntroductionSevere thermal injury is characterized by profound morbidity and mortality. Advances in burn and critical care, including early excision and grafting, aggressive resuscitation and advances in antimicrobial therapy have made substantial contributions to decrease morbidity and mortality. Despite these advances, death still occurs. Our aim was to determine the predominant causes of death in burned pediatric patients in order to develop new treatment avenues and future trajectories associated with increased survival. Methods: Primary causes of death were reviewed from 144 pediatric autopsy reports. Percentages of p...
Source: Critical Care - November 17, 2009 Category: Intensive Care Authors: Felicia WilliamsDavid HerndonHal HawkinsJong LeeRobert CoxGabriela KulpCeleste FinnertyDavid ChinkesMarc Jeschke Source Type: journals

The Value of a Risk Model for Early-onset CandidemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Blood stream infections from Candida species are associated with an increased length of stay, increased hospital costs, and higher mortality when compared to bacterial blood stream infections. Delayed or inappropriate therapy in candidemia leads to increased mortality, thus early recognition becomes paramount. With biomarkers showing promise, blood cultures still remain the gold standard but require 24-72 hours for growth. Thus, the reliance on epidemilogic risk factors for the initiation of empiric antifungal therapy provides the best method for early appropriate therapy. Shorr and colleagues have devised a risk score to ...
Source: Critical Care - November 16, 2009 Category: Intensive Care Authors: Christian SandrockJaveed Siddqui Source Type: journals

Ventilator-induced endothelial activation and inflammation in the lung and distal organsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data implicate that MV causes endothelial activation and inflammation in mice without pre-existing pulmonary injury, both in the lung and distal organs. (Source: Critical Care)
Source: Critical Care - November 16, 2009 Category: Intensive Care Authors: Maria HegemanMarije HennusCobi HeijnenPatricia SpechtBurkhard LachmannNicolaas JansenAdrianus van VughtPieter Cobelens Source Type: journals

Evaluation of modernisation of adult critical care services in EnglandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective was to evaluate the impact of a programme of transformation initiated in late 2000, key elements of which included funding for a 35% increase in the number of critical beds, the creation of 29 clinical networks, covering the whole country and sharing agreed protocols, and, within hospitals, the establishment of outreach services and the adoption of care bundles. The main findings reported were as follows (taken from the abstract): . In the six years after 2000, the risk of unit mortality adjusted for case mix fell by 11.3% and hospital ... (Source: NeLM - Intensive Care (ICU))
Source: NeLM - Intensive Care (ICU) - November 13, 2009 Category: Intensive Care Source Type: organizations

Sepsis and multiple organ failure represent a chaotic adaptation to severe stress which must be controlled at nano-scaleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We claim that sepsis and multiple organ failure represent an adaptive process that aims a survival advantage. Dynamic nature of sepsis comprise all of the key properties of a chaotic system. Chaotic and complex systems actually aim order and integrity, and their behaviours cannot be explained by linear statistical methods. That's why pathophysiology of sepsis and multiple organ failure must be re-modeled within the context of chaos and complexity theories. We also claim that one of the underlying reasons of difficulty in bench to bedside transition of experimental data is the difficulty in applying therapies at the propose...
Source: Critical Care - November 12, 2009 Category: Intensive Care Authors: Yusuf KilicIlke KilicMesut Tez Source Type: journals

Unraveling the Role of HMGB1 in Severe TraumaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
High mobility group box protein (HMGB1) has been shown to participate in acute inflammatory reactions, including acute lung injury and sepsis. There is also evidence that circulating levels of HMGB1 are increased after severe trauma and are associated with clinically important outcome parameters, including mortality. Recent studies demonstrated that HMGB1 itself has little or no proinflammatory activity, but is able to potentiate inflammatory responses through binding to mediators, such as endotoxin or cytokines. Important questions are to determine the binding partners for HMGB1 in the setting of severe injury and whether...
Source: Critical Care - November 12, 2009 Category: Intensive Care Authors: Edward Abraham Source Type: journals

Open the doors of the ICU to patients with malignancies and neurological complicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s00134-009-1713-zAuthors Michael Piagnerelli, Erasme University Hospital, Université Libre de Bruxelles Department of Intensive Care 808, route de Lennik 1070 Brussels BelgiumBenjamin Legros, Erasme University Hospital, Université Libre de Bruxelles Department of Neurology 808, route de Lennik 1070 Brussels Belgium Journal Intensive Care MedicineOnline ISSN 1432-1238Print ISSN 0342-4642 (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - November 11, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Central neurological complications in critically ill patients with malignanciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion In cancer patients, central neurological events are mainly related to malignant brain infiltration and drug-related toxicity. Despite advanced severity, a standardized intensive management strategy yields a 55% hospital survival rate. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1709-8Authors Stéphane Legriel, Hôpital Saint-Louis Medical Intensive Care Unit, AP-HP 75010 Paris FranceHélène Marijon, Hôpital Saint-Louis Medical Intensive Care Unit, AP-HP 75010 Paris FranceMichael Darmon, Hôpital Saint-Louis Medical Intensive Care Unit, AP-HP 75010 Paris FranceVirgin...
Source: Intensive Care Medicine - November 11, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

A Proposed Algorithm for Initiation of Renal Replacement Therapy in Adult Critically Ill PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this algorithm is to provide a starting point to guide clinicians on when to initiate RRT in critically ill adult patients. In addition, the proposed algorithm is intended to provide a foundation for prospective evaluation and the development of a broad consensus on when to initiate RRT in critically ill patients. (Source: Critical Care)
Source: Critical Care - November 11, 2009 Category: Intensive Care Authors: Sean BagshawDinna CruzNoel GibneyClaudio Ronco Source Type: journals

Transpulmonary thermodilution-derived cardiac function index identifies cardiac dysfunction in acute heart failure and septic patients: an observational studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Whereas the pulmonary artery catheter (PAC) is still widely used in guiding assessment and treatment of heart failure, controversy surrounding its safety and efficacy has prompted development of newer less invasive techniques. For these purposes, the transpulmonary thermodilution technique (TPT) allows assessment of preload, cardiac output, filling volumes, and metrics of contractility without the need to pass a catheter through the right heart. But these metrics remain relatively untested in heart failure. In this issue of Critical Care, Ritter and colleagues compare metrics of TPT to the PAC in patients with acute heart ...
Source: Critical Care - November 11, 2009 Category: Intensive Care Authors: Christopher VernonCharles Phillips Source Type: journals

Primary graft dysfunction: it's all the RAGE.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19897768 [PubMed - in process] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 10, 2009 Category: Intensive Care Authors: Wilkes DS Tags: Am J Respir Crit Care Med Source Type: journals

Searching for the tuberculosis "needle in the haystack": do we need a new approach to find tuberculosis in countries with a low burden of tuberculosis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19897769 [PubMed - in process] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 10, 2009 Category: Intensive Care Authors: Migliori GB, Weis S Tags: Am J Respir Crit Care Med Source Type: journals

Approaches to achieving universal health care in the United States: where should the American thoracic society stand?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19897770 [PubMed - in process] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 10, 2009 Category: Intensive Care Authors: Brown LK, Marcy TW, Kissner D, Douglas I, Tags: Am J Respir Crit Care Med Source Type: journals

Pro: single-payer health care: simple, fair, and affordable.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19897771 [PubMed - in process] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 10, 2009 Category: Intensive Care Authors: Day JA Tags: Am J Respir Crit Care Med Source Type: journals

Con: single-payer health care: why it's not the best answer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19897772 [PubMed - in process] (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 10, 2009 Category: Intensive Care Authors: Diamond MA Tags: Am J Respir Crit Care Med Source Type: journals