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Intensive Care

This page shows you the most recent publications within this specialty of the MedWorm directory.

Systemic matrix metalloproteinase‐8 and tissue inhibitor of metalloproteinases‐1 levels in severe sepsis‐associated coagulopathy
ConclusionIn this first human study, we could show that TIMP‐1 is elevated in the early phase of sepsis‐induced overt DIC, and it correlates both with degree of coagulopathy and disease severity. These findings suggest that TIMP‐1 may play a role in the pathogenesis of DIC in septic patients. (Source: Acta Anaesthesiologica Scandinavica)
Source: Acta Anaesthesiologica Scandinavica - October 20, 2014 Category: Anesthesiology Authors: M. SIVULA, J. HÄSTBACKA, A. KUITUNEN, R. LASSILA, T. TERVAHARTIALA, T. SORSA, V. PETTILÄ Tags: Original Article Source Type: research

The effect of goal-directed therapy on mortality in patients with sepsis - earlier is better: a meta-analysis of randomized controlled trials
Conclusions: The current meta-analysis suggests that GDT significantly reduces overall mortality in patients with sepsis, especially when initiated early. However, due to the variable quality of the studies, strong and definitive recommendations can not be made. (Source: Critical Care)
Source: Critical Care - October 20, 2014 Category: Intensive Care Authors: Wan-Jie GuFei WangJan BakkerLu TangJing-Chen Liu Source Type: research

Diagnosing external ventricular drain-related ventriculitis by means of local inflammatory response: soluble triggering receptor expressed on myeloid cells-1
IntroductionExternal ventricular drainage (EVD)-related ventriculitis is one of the most severe complications associated with the use of EVDs. Establishing an early and certain diagnosis can be difficult in critically ill patients. We performed this prospective study to evaluate the usefulness of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) determination in cerebrospinal fluid (CSF) in the diagnosis of ventriculitis. Methods: Prospective observational study of seventy-three consecutive patients with EVDs. Samples of CSF for culture, cytobiochemical analysis and sTREM-1 determination were extracted thr...
Source: Critical Care - October 20, 2014 Category: Intensive Care Authors: Monica GordonPaula RamirezAlex SorianoManuel PalomoCristina Lopez-FerrazEsther VillarrealSalome MeseguerMaria GomezCarlos FolgadoJuan Bonastre Source Type: research

A 'spicy' encephalopathy: synthetic cannabinoids as cause of encephalopathy and seizure
No abstract (Source: Critical Care)
Source: Critical Care - October 20, 2014 Category: Intensive Care Authors: Irene LouhWilliam Freeman Source Type: research

Circulating cytokines in predicting development of severe acute pancreatitis
Acute pancreatitis is an inflammatory disease process which may present with clinical manifestations ranging from benign self-limited disease to overwhelming sepsis. The ability to predict outcome would be helpful in developing treatment plans, and possibly in stratifying patients for clinical trials. (Source: Critical Care)
Source: Critical Care - October 20, 2014 Category: Intensive Care Authors: Ori Rotstein Source Type: research

The ProVent model learns to speak French
This study is noteworthy because it is the first to describe the performance of the ProVent model both outside the US and in a community hospital-based setting. (Source: Critical Care)
Source: Critical Care - October 20, 2014 Category: Intensive Care Authors: Christopher Cox Source Type: research

[Nocebo effects and negative suggestion in anesthesia.]
Abstract Anesthetists have an impact on patients and healing processes not only through drugs, interventions and therapy but also significantly by their words and personality. A substantial part of observed side effects is caused by nocebo effects and negative suggestion, i.e. by the doctor and the medical surroundings. Every symptom of an illness, side effect or complication can also be induced by the wrong way of talking about it. Patients perceive medical situations, such as an emergency, anesthesia or intensive care as extreme or even as life-threatening. This can induce a natural trance, an altered state of co...
Source: Der Anaesthesist - October 19, 2014 Category: Anesthesiology Authors: Zech N, Seemann M, Hansen E Tags: Anaesthesist Source Type: research

Elective Decompression of the Left Ventricle in Pediatric Patients May Reduce the Duration of Venoarterial Extracorporeal Membrane Oxygenation
Abstract We aimed to determine the effect of elective left heart decompression at the time of initiation of central venoarterial extracorporeal membrane oxygenation (VA ECMO) on VA ECMO duration and clinical outcomes in children in a single tertiary ECMO referral center with a large pediatric population from a national referral center for pediatric cardiac surgery. We studied 51 episodes of VA ECMO in a historical cohort of 49 pediatric patients treated between the years 1990 and 2013 in the Paediatric Intensive Care Unit (PICU) of the Royal Children's Hospital, Melbourne. The cases had a variety of diagnoses including con...
Source: Artificial Organs - October 19, 2014 Category: Transplant Surgery Authors: Douglas F. Hacking, Derek Best, Yves d'Udekem, Christian P. Brizard, Igor E. Konstantinov, Johnny Millar, Warwick Butt Tags: Main Text Article Source Type: research

[Correspondence] Syrian refugees in Turkey: effects on intensive care
Since the civilian war in Syria began, millions of Syrian refugees have migrated to neighbouring countries. According to the Disaster and Emergency Management Agency of the Turkish Government, by July 18, 2014, 1 000 103 Syrian refugees were registered in and outside of the 22 camps in 11 provinces in Turkey. By April 19, 2014, 43 197 surgical operations, excluding caesarean sections and spontaneous deliveries, were done in the Syrian refugee population. Thousands of seriously injured trauma patients from Syria were brought to Turkey for emergency operations and postoperative intensive care. (Source: LANCET)
Source: LANCET - October 18, 2014 Category: Journals (General) Authors: Hatice K Ozdogan, Faruk Karateke, Mehmet Ozdogan, Salim Satar Tags: Correspondence Source Type: research

[Series] Postinjury abdominal compartment syndrome: from recognition to prevention
Postinjury abdominal compartment syndrome (ACS) is an example of a deadly clinical occurrence that was eliminated by strategic research and focused preventions. In the 1990s, the syndrome emerged with the widespread use of damage control surgery and aggressive crystalloid-based resuscitation. Patients who previously exsanguinated on the operating made it to intensive care units, but then developed highly lethal hyperacute respiratory, renal, and cardiac failure due to increased abdominal pressure. (Source: LANCET)
Source: LANCET - October 18, 2014 Category: Journals (General) Authors: Zsolt J Balogh, William Lumsdaine, Ernest E Moore, Frederick A Moore Tags: Series Source Type: research

Mode of delivery and other risk factors for Escherichia coli infections in very low birth weight infants
Background: Infections in newborns remain one of the most significant problems in modern medicine. Escherichia coli is an important cause of neonatal bloodstream and respiratory tract infections and is associated with high mortality. The aim of our study was to investigate the epidemiology of E. coli infection in Polish neonatal intensive care units (NICUs) and resistance to antibiotics, with particular reference to the safety of very low birth weight infants. Methods: Continuous prospective infection surveillance was conducted in 2009-2012 in five NICUs, including 1,768 newborns whose birth weight was (Source: BMC Pediatrics)
Source: BMC Pediatrics - October 18, 2014 Category: Pediatrics Authors: Agnieszka ChmielarczykJadwiga Wójkowska-MachDorota RomaniszynPawe¿ AdamskiEwa HelwichRyszard LauterbachMonika PobiegaMaria Borszewska-KornackaEwa Gulczy¿skaAgnieszka KordekPiotr Heczko Source Type: research

Am J Respir Crit Care Med; +48 new citations
48 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Respir Crit Care Med These pubmed results were generated on 2014/10/17PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - October 17, 2014 Category: Intensive Care Tags: Report Source Type: research

Evaluation of neuromotor development by means of the Harris Infant Neuromotor Test
Conclusion: The test allowed nurses to assess infant development, identify deviations early, and plan interventions.Objetivo: Investigar el desarrollo neuromotor de los niños en riesgo entre tres y 12 meses de vida, por medio de la versión brasileña del Harris Infant Neuromotor Test (HINT). Método: Estudio longitudinal con 78 niños y 76 padres egresados ​​de una Unidad de Cuidados Intensivos Neonatales en Fortaleza-CE, Brasil. Se aplicaron dos instrumentos: HINT y un cuestionario socioeconómico, entre los meses de julio de 2009 a agosto de 2010. Se analizaron 55 niños prematuros y 23 niños nacidos de término. ...
Source: Revista da Escola de Enfermagem da USP - October 17, 2014 Category: Nursing Source Type: research

The Effect of Ex Vivo CDDO-Me Activation on Nuclear Factor Erythroid 2–Related Factor 2 Pathway in White Blood Cells From Patients With Septic Shock
The objective of this study was to test the hypothesis that ex vivo methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate (CDDO-Me) activates NRF2-regulated antioxidant genes in white blood cells from patients with septic shock and protects against LPS-induced inflammation and reactive oxidative species production. Peripheral blood was collected from 18 patients with septic shock who were being treated in medical and surgical intensive care units. Real-time polymerase chain reaction was used to quantify the expression of NRF2 target genes (NQO1, HO-1, GCLM, and FTL) and IL-6 in peripheral blood mononuclear cells (PBMCs), monocyt...
Source: Shock - October 17, 2014 Category: Emergency Medicine Tags: Clinical Aspects Source Type: research

Persistent Lymphopenia After Diagnosis of Sepsis Predicts Mortality
Conclusions: Persistent lymphopenia on the fourth day following the diagnosis of sepsis predicts early and late mortality and may serve as a biomarker for sepsis-induced immunosuppression. (Source: Shock)
Source: Shock - October 17, 2014 Category: Emergency Medicine Tags: Clinical Aspects Source Type: research

Pure motor monoparesis of the leg after carbon monoxide intoxication
A woman in her late 40s with no medical history presented as comatose (Glasgow Coma Scale (GCS) score, 8) after a suicide attempt, where she inhaled the fumes of burning charcoal for approximately 4 h. On admission, her blood pressure was 108/70 mm Hg, and her heart rate was 118 bpm. Her carbon monoxide (CO)–haemoglobin concentration was 34%. Blood examinations did not show any evidence of drug overdose. Supportive mechanical ventilation was employed, and she became alert after 48 h. A physical examination revealed no abnormal findings except for left leg weakness, and a neurological examinat...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 17, 2014 Category: Neurosurgery Authors: Tajima, Y., Satoh, C., Yaguchi, H., Mito, Y. Tags: Coma and raised intracranial pressure, Neurological injury, Stroke, Trauma CNS / PNS, Hypertension, Unwanted effects / adverse reactions, Drugs misuse (including addiction), Suicide (psychiatry), Radiology, Adult intensive care, Mechanical ventilation, Me Source Type: research

Platelet count and function in paediatric cardiac surgery: a prospective observational study
Conclusions Platelet count and platelet aggregation are markedly reduced during and immediately after paediatric cardiac surgery, especially in neonates. The recovery in aggregation is faster than that in platelet count. Intraoperative platelet dysfunction is associated with increased transfusion requirements. (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - October 17, 2014 Category: Anesthesiology Authors: Romlin, B. S., Soderlund, F., Wahlander, H., Nilsson, B., Baghaei, F., Jeppsson, A. Tags: Paediatrics Source Type: research

Predictive accuracy of triage nurses evaluation in risk stratification of syncope in the emergency department
Conclusions Nursing triage was characterised by a low predictive accuracy in identifying high-risk individuals. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - October 17, 2014 Category: Emergency Medicine Authors: Bonzi, M., Fiorelli, E. M., Angaroni, L., Furlan, L., Solbiati, M., Colombo, C., Dipaola, F., Montano, N., Furlan, R., Costantino, G. Tags: Resuscitation Original article Source Type: research

RE: Incidence and outcome of in-hospital cardiac arrest in the United Kingdom Cardiac Arrest Audit–can we clarify our purpose and shift the paradigm?
We note with interest the NCCA audit report which describes a national cardiac arrest rate of 1.6/1000 admissions within a United Kingdom context. We believe that cardiac arrests (with resuscitation attempts) in acutely unwell adult in-patients (excluding intensive care units, coronary care units and accident and emergency departments) often represent avoidable harm and that prevention is better than cure. This is especially relevant for cardiac arrests where outcomes are particularly poor.1 (Source: Resuscitation)
Source: Resuscitation - October 17, 2014 Category: Emergency Medicine Authors: Charlotte Hopkins Tags: Letter to the Editor Source Type: research

Choosing Wisely® in Critical Care: Maximizing Value in the Intensive Care Unit
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 16, 2014 Category: Emergency Medicine Tags: Special Editorial Source Type: research

The Changing Role of Palliative Care in the ICU
Conclusions: Palliative care is increasingly accepted as an essential component of comprehensive care for critically ill patients, regardless of diagnosis or prognosis. A variety of strategies to improve ICU palliative care appear to be effective, and resources including technical assistance and tools are available to support improvement efforts. As the longer-term impact of intensive care on those surviving acute critical illness is increasingly documented, palliative care can help prepare and support patients and families for challenges after ICU discharge. Further research is needed to inform efforts to integrate pallia...
Source: Critical Care Medicine - October 16, 2014 Category: Emergency Medicine Tags: Concise Definitive Review Source Type: research

ICU Physician-Based Determinants of Life-Sustaining Therapy During Nights and Weekends: French Multicenter Study From the Outcomerea Research Group*
Conclusions: Patients admitted during nights/weekends were younger and had fewer comorbidities. Age, specialty, ICU experience, and religious beliefs of the physicians were significantly associated life-sustaining treatments used. (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 16, 2014 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Error in Intensive Care: Psychological Repercussions and Defense Mechanisms Among Health Professionals
Conclusions: It is important to take into account the psychological experience of error and the defense mechanisms developed following an error because they appear to determine the professional’s capacity to acknowledge and disclose his/her error and to learn from it. (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 16, 2014 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

The Pediatrix BabySteps® Data Warehouse — A Unique National Resource for Improving Outcomes for Neonates
Abstract The Pediatrix Medical Group Clinical Data Warehouse represents a unique electronic data capture system for the assessment of outcomes, the management of quality improvement (CQI) initiatives, and the resolution of important research questions in the neonatal intensive care unit (NICU). This system is described in detail and the manner in which the Data Warehouse has been used to measure and improve patient outcomes through CQI projects and research is outlined. The Pediatrix Data Warehouse now contains more than 1 million patients, serving as an exceptional tool for evaluating NICU care. Examples are prov...
Source: Indian Journal of Pediatrics - October 16, 2014 Category: Pediatrics Source Type: research

Ventilator-Associated Pneumonia in Pediatric Intensive Care Unit
(Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - October 16, 2014 Category: Pediatrics Source Type: research

Outbreak of adenovirus type 1 severe pneumonia in a French intensive care unit, September-October 2012.
PMID: 25306980 [PubMed - in process] (Source: Euro Surveill)
Source: Euro Surveill - October 16, 2014 Category: Infectious Diseases Authors: Cassir N, Hraiech S, Nougairede A, Zandotti C, Fournier P, Papazian L Tags: Euro Surveill Source Type: research

Design and prospective validation of a dosing instrument for continuous infusion of vancomycin: a within-population approach
Conclusions An easy method to design and validate an eGFR-derived dosing algorithm for the continuous infusion of vancomycin to switch from intermittent to continuous dosing of vancomycin was developed. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 16, 2014 Category: Drugs & Pharmacology Source Type: research

Beyond the evidence: treating pulmonary hypertension in the intensive care unit
Most patients with pulmonary arterial hypertension succumb to their disease in the ICU; however, limited evidence-based information exists to guide treatment in those that present with advanced right ventricular failure. Critical care physicians should be aware of the complexities of the treatment of patients with pulmonary arterial hypertension and should develop a strategy for their care. Current management is based on the pathophysiology of the disease and involves a multidisciplinary team supported by institutional polices directed at optimizing patient safety. (Source: BioMed Central)
Source: BioMed Central - October 16, 2014 Category: Journals (General) Authors: Seth R BauerAdriano R Tonelli Source Type: research

Heparin therapy reduces 28-day mortality in adult severe sepsis patients: a systematic review and meta-analysis
IntroductionThere are approximately 19 million new cases of sepsis worldwide each year. Among them, more than one-quarter of patients die. We aimed to assess the effects of heparin on short term mortality in adult patients with sepsis and severe sepsis. Methods: We searched electronic databases (Medline, Embase, and Cochrane Library databases; the Cochrane Controlled Trials Register) and conference proceedings (Web of Knowledge (Conference Proceedings Citation Index - Science, Conference Proceedings Citation Index - Social Sciences & Humanities)) from inception to July 2014, expert contacts and relevant websites. Controlle...
Source: Critical Care - October 16, 2014 Category: Intensive Care Authors: Changsong WangChunjie ChiLei GuoXiaoyang WangLibo GuoJiaxiao SunBo SunShanshan LiuXuenan ChangEnyou Li Source Type: research

Magnesium sulfate exposure and neonatal intensive care unit admission at term
amp; D J Lyell (Source: Journal of Perinatology)
Source: Journal of Perinatology - October 16, 2014 Category: Perinatology & Neonatology Authors: A I GirsenM B GreenbergY Y El-SayedH LeeB CarvalhoD J Lyell Source Type: research

Clinical outcome and cost of treatment and care for neonates less than 1000 grams admitted to Vali-e ASR Hospital
Conclusion: Medication, medical supplies and equipment cost was significantly high. This is especially due to the fact that the present types of insurances do not cover such expenses very well, forcing parents to pay themselves. Insurance systems are expected to take this issue into immediate account. (Source: Health Economics Review)
Source: Health Economics Review - October 16, 2014 Category: Health Management Authors: Hosein DaliliMohaddese FallahiSaeid MoradiFatemeh NayeriMamak ShariatArash Rashidian Source Type: research

Morbid obesity in liver transplant recipients adversely affects longterm graft and patient survival in a single‐institution analysis
ConclusionsObesity increasingly impacts outcomes in liver transplantation. Although the present data are limited by the fact that they were sourced from a single institution, they suggest that morbid obesity adversely affects longterm outcomes despite providing similar short‐term results. Further analysis is indicated to identify risk factors for poor outcomes in morbidly obese patients. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 16, 2014 Category: Gastroenterology Authors: Kendra D. Conzen, Neeta Vachharajani, Kelly M. Collins, Christopher D. Anderson, Yiing Lin, Jason R. Wellen, Surendra Shenoy, Jeffrey A. Lowell, M. B. Majella Doyle, William C. Chapman Tags: Original Article Source Type: research

Effect of PEEP on breath sound power spectra in experimental lung injury
Conclusions: We confirm a gravity-related spectral amplitude increase of basic flow-induced breath sounds recorded over lung regions affected by permeability-type pulmonary edema and show that such changes are reversible by alveolar recruitment with PEEP. (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - October 16, 2014 Category: Surgery Authors: Jukka RäsänenMichael NemergutNoam Gavriely Source Type: research

Understanding clinical trials: emerging methodological issues
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 15, 2014 Category: Intensive Care Source Type: research

What’s new in management of traumatic coagulopathy?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 15, 2014 Category: Intensive Care Source Type: research

Predictors of difficult intubation in ICU: are children and adults alike?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 15, 2014 Category: Intensive Care Source Type: research

My paper 20 years later: effects of dobutamine on the VO 2 /DO 2 relationship
Conclusion The relationship between VO2 and DO2 remains an important concept. Abnormal global VO2/DO2 dependency does not exist in stable, critically ill patients, but can exist in circulatory shock of all etiologies. It can also occur regionally in septic patients, and microcirculatory alterations may contribute. Patient management should be titrated individually with careful assessment to identify those who will benefit from increased DO2. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 15, 2014 Category: Intensive Care Source Type: research

Comparison of two repositioning schedules for the prevention of pressure ulcers in patients on mechanical ventilation with alternating pressure air mattresses
Conclusions A strategy aimed at increasing repositioning frequency (2 versus 4 h) in patients under MV and on an APAM did not reduce the incidence of pressure ulcers. However, it did increase device-related adverse events and daily nursing workload. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 15, 2014 Category: Intensive Care Source Type: research

Big babies and big adults surprise us by their outcomes: why?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 15, 2014 Category: Intensive Care Source Type: research

A meaningful closure
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 15, 2014 Category: Intensive Care Source Type: research

What’s new in ECMO: scoring the bad indications
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 15, 2014 Category: Intensive Care Source Type: research

Prevalence, risk factors and consequences of severe burnout syndrome in ICU
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - October 15, 2014 Category: Intensive Care Source Type: research