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This page shows you the most recent publications within this specialty of the MedWorm directory.

Automated pulmonary nodule CT image characterization in lung cancer screening
Conclusion Nodule classification in the context of low-resolution low-dose whole-chest CT images for the clinically relevant size range in the context of lung cancer screening is highly challenging, and results are moderate compared to what has been reported in the literature for other clinical contexts. Nodule class size distribution imbalance needs to be considered in the training and evaluation of computer-aided diagnostic systems for producing patient-relevant outcomes. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - June 29, 2015 Category: Intensive Care Source Type: research

Enriching 3D optical surface scans with prior knowledge: tissue thickness computation by exploiting local neighborhoods
Abstract Purpose Patient immobilization and X-ray-based imaging provide neither a convenient nor a very accurate way to ensure low repositioning errors or to compensate for motion in cranial radiotherapy. We therefore propose an optical tracking device that exploits subcutaneous structures as landmarks in addition to merely spatial registration. To develop such head tracking algorithms, precise and robust computation of these structures is necessary. Here, we show that the tissue thickness can be predicted with high accuracy and moreover exploit local neighborhood information within the laser ...
Source: International Journal of Computer Assisted Radiology and Surgery - June 29, 2015 Category: Intensive Care Source Type: research

The Influence of Fluid Overload on the Length of Mechanical Ventilation in Pediatric Congenital Heart Surgery
This study is a retrospective chart review of patients who underwent congenital heart surgery between June 2010 and December 2013. Univariate and multivariate associations between maximum cumulative fluid balance and length of mechanical ventilation and OI were tested using the Spearman correlation test and multiple linear regression models, respectively. There were 85 eligible patients. Maximum cumulative fluid balance was associated with duration of mechanical ventilation (adjusted analysis beta coefficient = 0.53, CI 0.38–0.66, P < 0.001), length of stay in the pediatric intensive care unit (Spearman’s correl...
Source: Mammalian Genome - June 29, 2015 Category: Genetics & Stem Cells Source Type: research

Sciatic Neuropathy Caused by Focal Venous Engorgement Associated with Deep Vein Thrombosis: A Case Report
Publication date: Available online 14 June 2015 Source:PM&amp;R Author(s): Young-ah Choi , Keewon Kim A 69-year-old woman complained of severe left leg weakness with paresthesia. Electrodiagnostic tests revealed sciatic neuropathy, and imaging studies showed venous engorgement around the sciatic nerve. After anticoagulant therapy and intensive rehabilitation, the patient’s muscle strength improved from 1 to 3 on the Medical Research Council scale. The diagnosis of sciatic neuropathy caused by DVT is extremely rare; however, it should be considered in the differential diagnosis of unilateral lower extremity weakness...
Source: PMandR - June 29, 2015 Category: Rehabilitation Source Type: research

Association between prehospital vitamin D status and incident acute respiratory failure in critically ill patients: a retrospective cohort study.
CONCLUSIONS: Prehospital 25(OH)D was associated with the risk of acute respiratory failure in our critically ill patient cohort. PMID: 26113982 [PubMed] (Source: Respiratory Care)
Source: Respiratory Care - June 28, 2015 Category: Respiratory Medicine Authors: Thickett DR, Moromizato T, Litonjua AA, Amrein K, Quraishi SA, Lee-Sarwar KA, Mogensen KM, Purtle SW, Gibbons FK, Camargo CA, Giovannucci E, Christopher KB Tags: BMJ Open Respir Res Source Type: research

[Etiology, clinical presentation and outcome of severe viral acute childhood encephalitis (ECOVE study)].
CONCLUSIONS: In the Spanish PICU etiological diagnosis was established only in a third of cases of children with suspected acute viral encephalitis. Despite the clinical severity we observed a low mortality and morbidity rate. At discharge from the PICU, most children had no neurological sequelae or were mild. PMID: 26108903 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - June 28, 2015 Category: Neurology Authors: Flores-Gonzalez JC, Jordan-Garcia I, Turon-Vinas E, Montero-Valladares C, Tellez-Gonzalez C, Fernandez-Carrion F, Garcia-Iniguez JP, Onate-Vergara E, Rodriguez-Nunez A Tags: Rev Neurol Source Type: research

Effects of various antimicrobial stewardship programs on antimicrobial usage and resistance among common gram-negative bacilli causing healthcare-associated infections: a multicenter comparison
Conclusions This inter-hospital comparison suggested that hospital-wide pre-authorization program is the most effective to reduce key gram-negative bacilli resistance, with the exception of carbapenem-resistant A. baumannii. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - June 28, 2015 Category: Microbiology Source Type: research

Pressure Measurement Techniques for Abdominal Hypertension: Conclusions from an Experimental Model.
Conclusions from an Experimental Model. Crit Care Res Pract. 2015;2015:278139 Authors: Chopra SS, Wolf S, Rohde V, Freimann FB Abstract Introduction. Intra-abdominal pressure (IAP) measurement is an indispensable tool for the diagnosis of abdominal hypertension. Different techniques have been described in the literature and applied in the clinical setting. Methods. A porcine model was created to simulate an abdominal compartment syndrome ranging from baseline IAP to 30 mmHg. Three different measurement techniques were applied, comprising telemetric piezoresistive probes at two different sites (epigas...
Source: Critical Care Research and Practice - June 27, 2015 Category: Intensive Care Tags: Crit Care Res Pract Source Type: research

A 2015 Update on Ventilator-Associated Pneumonia: New Insights on Its Prevention, Diagnosis, and Treatment
Abstract Ventilator-associated pneumonia (VAP), an infection of the lower respiratory tract which occurs in association with mechanical ventilation, is one of the most common causes of nosocomial infection in the intensive care unit (ICU). VAP causes significant morbidity and mortality in critically ill patients including increased duration of mechanical ventilation, ICU stay and hospitalization. Current knowledge for its prevention, diagnosis and management is therefore important clinically and is the basis for this review. We discuss recent changes in VAP surveillance nomenclature incorporating ventilator-assoc...
Source: Current Infectious Disease Reports - June 27, 2015 Category: Infectious Diseases Source Type: research

Prevalence of Klebsiella pneumoniae strains producing carbapenemases and increase of resistance to colistin in an Italian teaching hospital from January 2012 To December 2014
This study was performed from January 1, 2012 to December 31, 2014. In 2012, a survey was conducted in the Intensive Care Department. In autumn 2013, active monitoring was extended to the Surgery Department, and since mid-2014, the surveillance has included the Medical Department as well. Only the first isolated strain from each patient was included. Antimicrobial susceptibility testing was performed on CPKP isolates: Klebsiella pneumoniae carbapenemase, oxacillinase-48, Verona integron-encoded metallo-β-lactamase and New Delhi metallo-β-lactamase were detected using a validated in-house PCR method, and multilocus sequen...
Source: BMC Infectious Diseases - June 27, 2015 Category: Infectious Diseases Authors: Saverio ParisiAndrea BartoliniErica SantacatterinaElena CastellaniRoberto GhirardoAlessandro BertoElisa FranchinNicola MenegottoEttore De CanaleTiziana TommasiniRoberto RinaldiMonica BassoStefania StefaniGiorgio Palù Source Type: research

Oral malodorous gases and oral microbiota: From halitosis to carcinogenesis
Conclusion Further analysis of oral malodor might be useful in accessing the risk of aspiration pneumonia and oral cancer. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 27, 2015 Category: Biomedical Science Source Type: research

Pediatric Palliative Care in the Intensive Care Unit
The chronicity of illness that afflicts children in Pediatric Palliative Care and the medical technology that has improved their lifespan and quality of life make prognostication extremely difficult. The uncertainty of prognostication and the available medical technologies make both the neonatal intensive care unit and the pediatric intensive care unit locations where many children will receive Pediatric Palliative Care. Health care providers in the neonatal intensive care unit and pediatric intensive care unit should integrate fundamental Pediatric Palliative Care principles into their everyday practice. (Source: Critical...
Source: Critical Care Nursing Clinics of North America - June 27, 2015 Category: Nursing Authors: Kevin Madden, Joanne Wolfe, Christopher Collura Source Type: research

Predicting Which Patients Will Benefit From Palliative Care
Intensive care units provide a wide range of care to patients with serious or life-threatening conditions. This care provides excellent state-of-the-art interventions, often concentrated on meeting national health priorities and performance measures. Overall patient care and the resultant outcomes in the intensive care unit are superb. However, one area that needs improvement is the provision of high-quality palliative care (PC) and end-of-life care. Many providers and administrators now realize implementing PC in the critical care setting is vital to optimal patient outcomes. PC improves patient and family satisfaction an...
Source: Critical Care Nursing Clinics of North America - June 27, 2015 Category: Nursing Authors: Tonja Hartjes Source Type: research

Management of Right Heart Failure in the Intensive Care Unit
Right heart failure is a clinical syndrome of various causes that commonly involves failure of the right ventricle (RV). The hemodynamic hallmark of the syndrome is increasing central venous pressure and worsening cardiac output with a rising RV end-diastolic pressure. When dealing with RV failure, clinicians must assess and optimize the intravascular volume state, support RV contractility, and address any pathologic elevations of afterload so that systemic perfusion is preserved. Despite these measures, there may still be a need to offer rescue interventions to the failing RV in carefully selected patients. (Source: Clini...
Source: Clinics in Chest Medicine - June 27, 2015 Category: Respiratory Medicine Authors: Cyrus A. Kholdani, Wassim H. Fares Source Type: research

Integration of Palliative Care Services in the Intensive Care Unit
This article discusses the benefits and barriers to integration of ICU and palliative care services, and a stepwise approach to implementation of palliative care services. Integration of palliative care services into ICU workflow is increasingly seen as essential to providing high-quality, comprehensive critical care. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - June 27, 2015 Category: Respiratory Medicine Authors: Mary Baker, Jim Luce, Gabriel T. Bosslet Source Type: research

Adverse Event Reporting and Quality Improvement in the Intensive Care Unit
Patients in the intensive care unit are at high risk for experiencing adverse events and errors. The high-acuity health care needs of these vulnerable patients expose them to numerous medications, procedures, and health care providers. The occurrence of adverse events is associated with detriments to patient outcomes including increased mortality. Adverse event reporting is the most commonly used event-detection tool, but it should also be complimented with other tools such as trigger tools, chart review, and direct observation. Although adverse event reporting is essential for continuous improvement processes and is assoc...
Source: Clinics in Chest Medicine - June 27, 2015 Category: Respiratory Medicine Authors: Jason J. Heavner, Jonathan M. Siner Source Type: research

ICU Telemedicine Solutions
During the last 15 years, critical care services provided via telemedicine have expanded to now be incorporated into the care of 13% of patients in intensive care units (ICUs) in the United States. A response to shortfalls in the availability of critical care–trained providers has evolved into integrated programs of ICU care with contributions to improved outcomes through proactive management, population oversight, and standardization of care processes. The most impactful characteristics of successful ICU telemedicine programs are now better understood with more than a decade of national experience and the accrued benef...
Source: Clinics in Chest Medicine - June 27, 2015 Category: Respiratory Medicine Authors: Steven A. Fuhrman, Craig M. Lilly Source Type: research

Postoperative Complications After Distal Pancreatectomy Performed During Cytoreductive Surgery for Gynecologic Malignancies
Conclusion: In this series, the rate of pancreatic leak was lower than previously reported with no perioperative mortality or surgical reexploration. However, the time to initiation of chemotherapy was delayed in those who developed pancreatic leak. These data are important in patient counseling and decision making at the time of debulking surgery. Gynecologic oncologists considering distal pancreatectomy should be familiar with perioperative management of these patients. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - June 26, 2015 Category: Cancer & Oncology Tags: Surgeon's Corner Source Type: research

Cost-Effectiveness of Conventional vs Robotic-Assisted Laparoscopy in Gynecologic Oncologic Indications
Conclusions: The main driver of additional costs is the fixed cost of the robot, which is not compensated by the lower hospital room costs. The robot would be more cost-effective if robotic interventions were performed on a larger number of patients per year or if the purchase price of the robot was reduced. A shorter learning curve would also no doubt decrease the operating theater costs, resulting in financial benefits to society. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - June 26, 2015 Category: Cancer & Oncology Tags: Surgeon's Corner Source Type: research

Underuse of guideline-recommended long-term asthma management in children hospitalized to the intensive care unit: a multicenter observational study
Despite the significant burden of childhood asthma, little is known about prevention-oriented management before and after hospitalizations for asthma exacerbation. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - June 26, 2015 Category: Allergy & Immunology Authors: Kohei Hasegawa, Jason Ahn, Mark A. Brown, Valerie G. Press, Susan Gabriel, Vivian Herrera, Jane C. Bittner, Carlos A. Camargo, MARC-37 Investigators Tags: Original article Source Type: research

Sleep Neurobiology and Critical Care Illness
This article discusses elements of sleep neurobiology affecting the specificity of sleep patterns and sleep alterations in patients admitted to the ICU. (Source: Critical Care Clinics)
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Authors: Xavier Drouot, Solene Quentin Source Type: research

Neuromuscular Disorders and Sleep in Critically Ill Patients
Sleep-disordered breathing (SDB) is a frequent presenting manifestation of neuromuscular disorders and can lead to significant morbidity and mortality. If not recognized and addressed early in the clinical course, SDB can lead to clinical deterioration with respiratory failure. The pathophysiologic basis of SDB in neuromuscular disorders, clinical features encountered in specific neuromuscular diseases, and diagnostic and management strategies for SDB in neuromuscular patients in the critical care setting are reviewed. Noninvasive positive pressure ventilation has been a crucial advance in critical care management, improvi...
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Authors: Muna Irfan, Bernardo Selim, Alejandro A. Rabinstein, Erik K. St. Louis Source Type: research

Circadian Dysrhythmias in the Intensive Care Unit
Circadian rhythms underlie nearly all physiologic functions and organ systems. Circadian abnormalities have attendant implications for critical illness survival. The intensive care unit (ICU) environment, with its lack of diurnal variation in sound, light, and social cues, may precipitate circadian dysrhythmias. Additional features of critical care, including mechanical ventilation and sedation, likely perpetuate circadian misalignment. Critical illness itself, from sepsis to severe brain injury, can compromise circadian health. Use of daylight, time-restricted feedings, and administration of melatonin can possibly restore...
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Authors: Martha E. Billings, Nathaniel F. Watson Source Type: research

Congestive Heart Failure and Central Sleep Apnea
Congestive heart failure (CHF) is among the most common causes of admission to hospitals in the United States, especially in those over age 65. Few data exist regarding the prevalence CHF of Cheyne–Stokes respiration (CSR) owing to congestive heart failure in the intensive care unit (ICU). Nevertheless, CSR is expected to be highly prevalent among those with CHF. Treatment should focus on the underlying mechanisms by which CHF increases loop gain and promotes unstable breathing. Few data are available to determine prevalence of CSR in the ICU, or how CSR might affect clinical management and weaning from mechanical ventil...
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Authors: Scott A. Sands, Robert L. Owens Source Type: research

Sleep and the Endocrine System
In this article, the effect of sleep and sleep disorders on endocrine function and the influence of endocrine abnormalities on sleep are discussed. Sleep disruption and its associated endocrine consequences in the critically ill patient are also reviewed. (Source: Critical Care Clinics)
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Authors: Dionne Morgan, Sheila C. Tsai Source Type: research

Noninvasive Ventilation in Critically Ill Patients
This article provides physicians and respiratory therapists with a comprehensive, practical guideline for using NIV in critical care. (Source: Critical Care Clinics)
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Authors: Cesare Gregoretti, Lara Pisani, Andrea Cortegiani, Vito Marco Ranieri Source Type: research

Sleep and Circadian Rhythms in the ICU
CRITICAL CARE CLINICS (Source: Critical Care Clinics)
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Authors: Vipin Malik Source Type: research

Sedation in Critically Ill Patients
Sedation in the intensive care unit (ICU) is a topic that has been frequently researched, and debate still exists as to what are the best sedative agents for critically ill patients. There is increasing interest in sleep and circadian rhythm disturbances in the ICU and how they may impact on outcomes. In addition to patient-related and ICU environmental factors that likely impact sleep and circadian rhythm in the ICU, sedative and analgesic medications may also play a role. (Source: Critical Care Clinics)
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Authors: Mark Oldham, Margaret A. Pisani Source Type: research

Seizures in Sleep
Sleep is disrupted in most patients hospitalized in the intensive care unit and the disturbances are even more profound in patients impacted by epilepsy. Nocturnal seizures must be differentiated from other common nocturnal events, such as delirium, parasomnias, and sedation. Many antiepileptic drugs produce undesirable side effects on sleep architecture that may further predispose patients to insomnia during the night and excessive sedation and hypersomnolence during the day. Failure to recognize, correctly diagnose, and adequately manage these disturbances may lead to more prolonged hospitalization, increased risk for no...
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Authors: Dawn Eliashiv, Alon Y. Avidan Source Type: research

Perioperative Issues and Sleep-Disordered Breathing
Sleep-disordered breathing in the perioperative setting poses an increase in both perceived and demonstrated challenges for health care providers. Some of these challenges relate to identifying patients at high risk for obstructive sleep apnea prior to surgery. Other management challenges include identifying the proper monitoring techniques, using the correct mix of pharmacologic and nonpharmacologic strategies to manage these patients, and identifying the proper and safe disposition strategy after surgery. Additional populations, such as pediatrics and the morbidly obese, are also highlighted, which may help address quest...
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Authors: Karen L. Wood, Beth Y. Besecker Source Type: research

Contents
Vipin Malik (Source: Critical Care Clinics)
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Source Type: research

Contributors
RICHARD W. CARLSON, MD, PhD (Source: Critical Care Clinics)
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Source Type: research

Copyright
ELSEVIER (Source: Critical Care Clinics)
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Source Type: research

Index
Note: Page numbers of article titles are in boldface type. (Source: Critical Care Clinics)
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Source Type: research

Forthcoming Issues
Nephrology (Source: Critical Care Clinics)
Source: Critical Care Clinics - June 26, 2015 Category: Intensive Care Source Type: research

Supporting Play Exploration and Early Development Intervention From NICU to Home: A Feasibility Study
Conclusions: SPEEDI is a feasible intervention and appropriate for future clinical trials. Video Abstract: For more insights from the authors, see Supplemental Digital Content 1, available at http://links.lww.com/PPT/A83 . (Source: Pediatric Physical Therapy)
Source: Pediatric Physical Therapy - June 26, 2015 Category: Pediatrics Tags: Research Article Source Type: research

Review of chronic obstructive airway disease patients admitted at Maamoura Chest Hospital from 2009 to 2012
Conclusions COPD is a very dangerous disease that affects the lives of many people. The overall aim of management of stable COPD is to ensure good control of symptoms, to slow down the progression of the disease and to prevent further deterioration or complications. The sooner the diagnosis is made and interventions implemented, the more the long-term prognosis is improved. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - June 26, 2015 Category: Respiratory Medicine Source Type: research

Stress among nurses working in emergency, anesthesiology and intensive care units depends on qualification: a Job Demand-Control survey
Conclusions In an acute care setting, a high level of education was a key factor for high job stress and was associated with a perception of a low control in the workplace, both of which may be predictors of adverse mental health. In particular, the lack of control has been associated with moral distress, a frequently reported characteristic of acute care settings. To enhance the personal and professional outcomes of the advanced registered nurses, strategies for supporting nurses manage daily stressors in acute care are urgently required. (Source: International Archives of Occupational and Environmental Health)
Source: International Archives of Occupational and Environmental Health - June 26, 2015 Category: Occupational Health Source Type: research

Persistently elevated Osteopontin serum levels predict mortality in critically ill patients
Conclusion: Persistently elevated OPN serum concentrations are associated with an unfavorable outcome in patients with critical illness, independent of the presence of sepsis. Besides a possible pathogenic role of OPN in critical illness, our study indicates a potential value for OPN as a prognostic biomarker in critically ill patients during the early course of ICU treatment. (Source: Critical Care)
Source: Critical Care - June 26, 2015 Category: Intensive Care Authors: Christoph RoderburgFabian BenzDavid Vargas CardenasMatthias LutzHans-Joerg HippeTom LueddeChristian TrautweinNorbert FreyAlexander KochFrank TackeMark Luedde Source Type: research

Nebulized colistin for treatment of ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: we still need to straighten out the dose!
No description available (Source: Critical Care)
Source: Critical Care - June 26, 2015 Category: Intensive Care Authors: Patrick HonoreRita JacobsInne HendrickxElisabeth De WaeleJouke De RegtHerbert Spapen Source Type: research

Heart donation and transplantation after circulatory death: ethical issues after Europe’s first case
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 26, 2015 Category: Intensive Care Source Type: research

Mass chemical casualties: Treatment of 41 patients with burns by anhydrous ammonia
Conclusion This mass casualty incident of anhydrous ammonia leakage caused potential devastating effects to the society, especially to the victims and their families. Early first-aid organization, emergency management, triage, and evacuation were of paramount importance, especially rapid evaluation of the severity of inhalation injury, and subsequent corresponding medical treatment. The prognosis of ammonia burns was poor and the sequelae were severe. Management and treatment lessons were drawn from this mass casualty chemical burn incident. (Source: Burns)
Source: Burns - June 26, 2015 Category: Dermatology Source Type: research

Hypoxia inhibits semicarbazide-sensitive amine oxidase activity in adipocytes
Publication date: 15 August 2015 Source:Molecular and Cellular Endocrinology, Volume 411 Author(s): Xavier Repessé , Marthe Moldes , Adeline Muscat , Camille Vatier , Gérard Chetrite , Thomas Gille , Carole Planes , Anna Filip , Nathalie Mercier , Jacques Duranteau , Bruno Fève Semicarbazide-sensitive amine oxidase (SSAO), an enzyme highly expressed on adipocyte plasma membranes, converts primary amines into aldehydes, ammonium and hydrogen peroxide, and is likely involved in endothelial damage during the course of diabetes and obesity. We investigated whether in vitro, adipocyte SSAO was modulated under hypoxic condi...
Source: Molecular and Cellular Endocrinology - June 26, 2015 Category: Endocrinology Source Type: research