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This page shows you the most recent publications within this specialty of the MedWorm directory.

Efficiency of gas transfer in venovenous extracorporeal membrane oxygenation: analysis of 317 cases with four different ECMO systems
Conclusion Our analysis suggests that patients with severe hypoxemia and need for high flow ECMO benefit more from the PLS/CH or Hilite 7000 LT system. The ECC.05 system is advisable for patients with moderate hypoxemia and/or hypercapnia. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - November 21, 2014 Category: Intensive Care Source Type: research

Risk of bloodstream infection in children admitted to paediatric intensive care units in England and Wales following emergency inter-hospital transfer
Conclusions Nationally, inter-hospital transfer is no longer a significant risk factor for PICU-acquired BSI. Given the large proportion of infection occurring in the second week of admission, initiatives to further reduce PICU-acquired BSI should focus on maintaining sterile procedures after admission. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - November 21, 2014 Category: Intensive Care Source Type: research

A revival for immunoglobulin therapy in septic shock?
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - November 21, 2014 Category: Intensive Care Source Type: research

Outcome measures report different aspects of patient function three months following critical care
Conclusions The 6MWT and TUG may both be acceptable measures of PF performance 3 months after ICU. Performance-based tests measure different constructs than self-report measures and choice of outcome variables should be aligned with study aims to ensure the most appropriate measure is used. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - November 21, 2014 Category: Intensive Care Source Type: research

The limitations of extracorporeal membrane oxygenation as a bridge to allogeneic hematopoietic stem cell transplantation
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - November 21, 2014 Category: Intensive Care Source Type: research

Family presence during cardiopulmonary resuscitation: an opportunity for meaning-making in bereavement
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - November 21, 2014 Category: Intensive Care Source Type: research

Venovenous extracorporeal CO 2 removal for early extubation in COPD exacerbations requiring invasive mechanical ventilation
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - November 21, 2014 Category: Intensive Care Source Type: research

Plight
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - November 21, 2014 Category: Intensive Care Source Type: research

Pathergy phenomenon: huge pyoderma gangrenosum following tube thoracostomy
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - November 21, 2014 Category: Intensive Care Source Type: research

A large vertebral artery pseudoaneurysm due to percutaneous internal jugular vein cannulation
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - November 21, 2014 Category: Intensive Care Source Type: research

Acute Cervical Myelopathy Due to Presumed Fibrocartilaginous Embolism: A Case Report and Systematic Review of the Literature
Conclusions:FCE is an unusual cause of spinal cord and cerebral ischemia with unknown incidence. Implementation of diagnostic imaging techniques and initial management of acute spinal disorders care in intensive care units might increase the incidence of disease antemortem. FCE should be considered in the differential diagnosis of ischemic spinal cord injury when no other causes can be identified and especially when the onset is progressive over several hours. (Source: Journal of Spinal Disorders and Techniques)
Source: Journal of Spinal Disorders and Techniques - November 21, 2014 Category: Surgery Tags: Original Articles Source Type: research

Family participation during intensive care unit rounds
In an earlier study, published in The Journal, Stickney et al from Boston Children’s Hospital evaluated the level of parental satisfaction with family attendance during pediatric intensive care unit rounds (J Pediatr 2014;164:404-6.e4). They found a high degree of parental satisfaction but a lower degree of healthcare provider satisfaction. In the current issue of The Journal, they report a new study of the goals and expectations of parents and healthcare providers in this setting. This was performed using qualitative methods; the parents were interviewed at bedside, and the healthcare providers participated in focus gro...
Source: The Journal of Pediatrics - November 21, 2014 Category: Pediatrics Authors: Robert W. Wilmott Tags: The Editors' Perspective Source Type: research

[Analysis of the Cochrane Review: Use of Systemic Corticosteroids for Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Cochrane Database Syst Rev. 2014, 9:CD001288.]
Authors: Azevedo P, Costa J, Vaz-Carneiro A Abstract Acute exacerbations of chronic obstructive pulmonary disease are a major cause of hospital admissions and mortality, contributing to the decline in lung function, exercise capacity and quality of life. Infections are the major cause of exacerbations and treatment includes antibiotics, bronchodilators and systemic corticosteroids as anti- inflammatory agents. This Cochrane review compared: 1. use of oral and parenteral corticosteroids with placebo use; 2. routes of administration among themselves. The results indicate that there is evidence for the use of corticos...
Source: Acta Medica Portuguesa - November 21, 2014 Category: Journals (General) Tags: Acta Med Port Source Type: research

Endogenous glycosaminoglycan anticoagulation in extracorporeal membrane oxygenation
A heparin-like effect was recently described in infants, children, and adults receiving bivalirudin while supported on extracorporeal membrane oxygenation following cardiopulmonary bypass. This is most likely due to endogenous release of glycosaminoglycans from vascular endothelium and mast cells and is associated with longer duration of extracorporeal membrane oxygenation and an increased incidence of sepsis. Further investigation into this effect should include patients without recent cardiopulmonary bypass, exclude the presence of covalent antithrombin-heparin complexes, and employ a variety of different heparinases for...
Source: Critical Care - November 21, 2014 Category: Intensive Care Authors: Graeme MacLarenPaul Monagle Source Type: research

The fluid management of adults with severe malaria
Fluid resuscitation has long been considered a key intervention in the treatment of adults with severe falciparum malaria. Profound hypovolemia is common in these patients and has the potential to exacerbate the acidosis and acute kidney injury that are independent predictors of death. However, new microvascular imaging techniques have shown that disease severity correlates more strongly with obstruction of the microcirculation by parasitized erythrocytes - a process termed sequestration. Fluid loading has little effect on sequestration and increases the risk of complications, particularly pulmonary edema, a condition that...
Source: Critical Care - November 21, 2014 Category: Intensive Care Authors: Josh HansonNicholas AnsteyDavid BihariNicholas WhiteNicholas DayArjen Dondorp Source Type: research

Atrial ejection force and brain natriuretic peptide as markers for mortality in sepsis
Conclusion Atrial ejection force on the first day of admission, unlike BNP level, might not be used as an independent predictor of mortality in patients with sepsis. BNP level correlates with the severity of sepsis. According to our study, AEF in the third day may be a good predictor for survival of patients presenting with sepsis. (Source: The Egyptian Journal of Critical Care Medicine)
Source: The Egyptian Journal of Critical Care Medicine - November 21, 2014 Category: Intensive Care Source Type: research

Etomidate is Still a Valid Anesthetic for Electroconvulsive Therapy
AbstractKomatsu et al have recently written that the use of etomidate as an anesthetic induction agent for surgery is associated with increased 30-day mortality and cardiovascular morbidity, compared with propofol. Etomidate has long been recognized as suppressing adrenocortical function and, as an infusion over days, has been indicted in increasing intensive care unit patient mortality. Even in single doses, etomidate causes a reduction in cortisol production, although recovery from single-dose suppression is generally prompt. In prospectively evaluating etomidate as an anesthetic for electroconvulsive therapy, Lebowitz e...
Source: The Journal of ECT - November 20, 2014 Category: Psychiatry Tags: Commentary Source Type: research

Prediction of Death in Less Than 60 Minutes After Withdrawal of Cardiorespiratory Support in Potential Organ Donors After Circulatory Death
ConclusionThis best predictive model missed only 18% of all potential donors. A positive prediction would be incorrect on only 20% of occasions, meaning there is an acceptable level of lost opportunity costs involved in the unnecessary assembly of transplantation teams and theatres. (Source: Transplantation)
Source: Transplantation - November 20, 2014 Category: Transplant Surgery Tags: Clinical and Translational Research Source Type: research

Volume: 21 Issue: 5
This article describes the presentation, work-up, diagnosis and treatment of a 50-year-old man who presented to the respiratory clinic with a two-year history of vocal hoarseness and progressive exertional dyspnea. History of respiratory medicine in Canada: A new Canadian Respiratory Journal series Hypersensitivity pneumonitis (extrinsic allergic alveolitis): A Canadian historical perspective Allergen-induced asthma Evaluation of an internal review process for grants and manuscripts in the Canadian Critical Care Trials GroupSeveral previous studies have evaluated the peer review process for journals or grant agencies. Howe...
Source: Canadian Respiratory Journal - November 20, 2014 Category: Respiratory Medicine Source Type: research

Removal of a Malpositioned Central Venous Catheter from a Direct Main Pulmonary Artery Puncture with Transthoracic Temporary Balloon Occlusion
An institutional review board exemption was obtained to publish this report. A 71-year-old man required a central venous catheter (CVC) in the intensive care unit after developing hypotension following elective endoscopic biopsy of a laryngeal mass. His comorbidities included severe obstructive pulmonary disease, sternotomy for removal of a malignant thymoma with right-sided phrenic nerve palsy, and a right lower lobectomy. (Source: Journal of Vascular and Interventional Radiology : JVIR)
Source: Journal of Vascular and Interventional Radiology : JVIR - November 20, 2014 Category: Radiology Authors: Ramanan Daniel, Vikram Patil, Ashutosh Hardikar, Scott Parkes, Jens J. Froelich Tags: Letter to the Editor Source Type: research

Understanding the Hematocrit Effect on Glucose Testing Using Popular Point-of-Care Testing Devices
AbstractThe use of point-of-care testing (PoCT) blood glucose meters has spread from their intended purpose in the home environment to hospital wards often without appropriate evaluation or understanding of the meter’s limitations. There is substantial evidence that many of the commonly used PoCT blood glucose meters are adversely affected by hematocrit, and their use in intensive care units or on neonates may potentially lead to errors in patient care and an increased risk of iatrogenic or undetected hypoglycemia or hyperglycemia.We explored the hematocrit interference on 3 glucose meters commonly used in hospital care:...
Source: Point of Care: The Journal of Near-Patient Testing and Technology - November 20, 2014 Category: Pathology Tags: Original Articles Source Type: research

Initial and Extended Use of Femoral Versus Nonfemoral Double-Lumen Vascular Catheters and Catheter-Related Infection During Continuous Renal Replacement Therapy
Conclusions CRCOL and CRBSI rates in patients on CRRT are low and not influenced significantly by initial or serial femoral catheterizations with guidewire exchange or new venipuncture. CRCOL risk is higher in older and heavier patients, the latter especially so with femoral sites. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - November 20, 2014 Category: Urology & Nephrology Source Type: research

Toxic epidermal necrolysis associated with deflazacort therapy with nephrotic syndrome
This report describes two cases of TEN, associated with deflazacort (DFZ), in two boys, aged 4 years and 14 years, with nephrotic syndrome (NS). The 14-year-old male teenager received DFZ following NS relapse. After 17 days, pruritic papules appeared on the lower extremities. Another case involved a 4-year-old boy receiving DFZ and enalapril. After a 41-day DFZ treatment period, erythematous papules appeared on the palms and soles. Within 3 days, both boys developed widespread skin lesions (>50%) and were admitted to the intensive care unit for resuscitative and supportive treatment. The patients showed improvement ...
Source: Kidney Research and Clinical Practice - November 20, 2014 Category: Urology & Nephrology Source Type: research

Search for biomarkers in critically ill patients: a new approach based on nuclear magnetic resonance spectroscopy of mini-bronchoalveolar lavage fluid
No abstract (Source: Critical Care)
Source: Critical Care - November 20, 2014 Category: Intensive Care Authors: Chandan SinghRatan RaiAfzal AzimNeeraj SinhaArvind Baronia Source Type: research

The NifTK software platform for image-guided interventions: platform overview and NiftyLink messaging
Conclusion These packages form part of the NifTK platform and have proven to be successful in a variety of image-guided surgery projects. Code and documentation for the NifTK platform are available from http://www.niftk.org. NiftyLink is provided open-source under a BSD license and available from http://github.com/NifTK/NiftyLink. The code for this paper is tagged IJCARS-2014. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - November 20, 2014 Category: Intensive Care Source Type: research

Morphometry-based measurements of the structural response to whole-brain radiation
Conclusion The presented study has developed an image processing pipeline for morphometric monitoring of brain tissue volume changes as a response to radiation therapy. Results indicate that quantitative morphometric monitoring is feasible and may provide additional information in assessing response. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - November 20, 2014 Category: Intensive Care Source Type: research

The role of automatic computer-aided surgical trajectory planning in improving the expected safety of stereotactic neurosurgery
Conclusions Computer-based patient-specific preoperative planning of surgical trajectories that minimize the expected risk of vascular and neurological damage due to incorrect tool placement is a promising technique that yields consistent improvements. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - November 20, 2014 Category: Intensive Care Source Type: research

Diffusion tensor tractography of normal facial and vestibulocochlear nerves
Conclusion Seed ROI modification and FA thresholding can improve the visualization of cranial nerve VII–VIII locations in DTT. This technique is promising for its potential to determine the relationship of cranial nerves VII–VIII to VS. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - November 20, 2014 Category: Intensive Care Source Type: research

Depletion of high affinity corticosteroid‐binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications
ConclusionsIncreasing illness severity in sepsis and septic shock is associated with markedly reduced circulating haCBG concentrations in vivo. We propose that low levels of haCBG in chronic inflammation may limit the availability of cortisol to inflammatory sites, perpetuating the inflammatory process.This article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - November 20, 2014 Category: Endocrinology Authors: MA Nenke, W Rankin, MJ Chapman, NE Stevens, KR Diener, JD Hayball, JG Lewis, DJ Torpy Tags: Original Article Source Type: research

Whole-genome analysis of an extensively drug-resistant clinical isolate of AC12: insights into the mechanisms of resistance of an ST195 clone from Malaysia
Acinetobacter baumannii has been implicated in a number of nosocomial infections, and the therapeutic options for these Acinetobacter infections have been a problem for clinicians, especially when the infections are caused by multidrug-resistant (MDR) isolates that produce carbapenemases [1]. Carbapenemase-producing A. baumannii has been extremely difficult to treat and has become a serious issue in intensive care units where carbapenems were among the last-resort treatments. This led to the re-introduction of an older class of drugs, the polymyxins, such as polymyxin B and colistin (polymyxin E). (Source: International Jo...
Source: International Journal of Antimicrobial Agents - November 20, 2014 Category: Drugs & Pharmacology Authors: Soo-Sum Lean, Chew Chieng Yeo, Zarizal Suhaili, Kwai-Lin Thong Tags: Short Communication Source Type: research

Comparison of recombinant human thrombomodulin and gabexate mesylate for treatment of disseminated intravascular coagulation (DIC) with sepsis following emergent gastrointestinal surgery: a retrospective study
Conclusion rTM may be an effective therapeutic drug for the treatment of septic patients with DIC following emergent gastrointestinal surgery. (Source: European Journal of Trauma and Emergency Surgery)
Source: European Journal of Trauma and Emergency Surgery - November 20, 2014 Category: Emergency Medicine Source Type: research

Evaluation of the surveillance system for undiagnosed serious infectious illness (USII) in intensive care units, England, 2011 to 2013
(Source: Eurosurveillance)
Source: Eurosurveillance - November 20, 2014 Category: Infectious Diseases Source Type: research

Health care workers' knowledge and practices regarding the prevention of central venous catheter-related infection
Conclusion The results of the present study revealed health care worker's low knowledge regarding the prevention of CVC-RI and low compliance with the standard guidelines of CVC care. Therefore, health care workers should be periodically evaluated for their knowledge and practices regarding guidelines for the prevention of CVC-RI. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - November 20, 2014 Category: Infectious Diseases Source Type: research

Acute ischemic stroke prognostication, comparison between Glasgow Coma Score, NIHS Scale and Full Outline of UnResponsiveness Score in intensive care unit
Conclusions The GCS and the FOUR score are accurate predictors of mortality after acute ischemic stroke, and are equal in prediction to the NIHSS. The NIHSS is more accurate than the GCS and the FOUR score in predicting poor neurologic outcome. (Source: Alexandria Journal of Medicine)
Source: Alexandria Journal of Medicine - November 20, 2014 Category: Journals (General) Source Type: research

Maternal outcomes of hypertensive disorders in pregnancy at Korle Bu Teaching Hospital, Ghana
Conclusion Hypertensive disorders in pregnancy are associated with high incidences of adverse maternal outcomes in Ghana, with significantly increased frequencies in women with pre-eclampsia. (Source: International Journal of Gynecology and Obstetrics)
Source: International Journal of Gynecology and Obstetrics - November 20, 2014 Category: OBGYN Source Type: research

Predictive models for kidney disease: improving global outcomes (KDIGO) defined acute kidney injury in UK cardiac surgery
Conclusions: This is the first risk score that accurately identifies patients at risk of any stage AKI. This score will be useful in the perioperative management of high risk patients as well as in clinical trial design. (Source: Critical Care)
Source: Critical Care - November 20, 2014 Category: Intensive Care Authors: Kate BirnieVeerle VerheydenDomenico PaganoMoninder BhabraKate TillingJonathan SterneGavin Murphyon behalf of the UK AKI in Cardiac Surgery Collaborators Source Type: research

A comparison of the health status and psychological distress of partners of patients with a left ventricular assist device versus an implantable cardioverter defibrillator: A preliminary study
To examine if the caregiving for patients with a left ventricular assist device (LVAD) is related to a poorer health status and more distress compared to patients with an implantable cardioverter defibrillator (ICD). (Source: Heart and Lung)
Source: Heart and Lung - November 20, 2014 Category: Intensive Care Authors: Corline Brouwers, Kadir Caliskan, Nicolaas de Jonge, Dominic A.J.M. Theuns, A. Constantinescu, Quincy-Robyn Young, Colleen Cannon, Johan D. denollet, Susanne S. Pedersen Source Type: research

Intermittent positive pressure ventilation increases diastolic pulmonary arterial pressure in advanced COPD
To measure the impact of intermittent positive pressure ventilation (IPPV) on diastolic pulmonary arterial pressure (dPAP) and pulmonary pulse pressure in patients with advanced COPD. (Source: Heart and Lung)
Source: Heart and Lung - November 20, 2014 Category: Intensive Care Authors: Jeremy P. Wrobel, Bruce R. Thompson, Christopher R. Stuart-Andrews, Kirk Kee, Gregory I. Snell, Mark Buckland, Trevor J. Williams Source Type: research

Postoperative Hyperoxia (60%) Worsens Hepatic Injury in Mice
Conclusion: Liver injury after ischemia was significantly aggravated by hyperoxia as a consequence of immune cell-mediated oxidative burst. Further studies are needed to elucidate whether routine delivery of high inspirational oxygen concentrations postoperatively should be limited. (Source: Anesthesiology)
Source: Anesthesiology - November 19, 2014 Category: Anesthesiology Tags: Perioperative Medicine: Basic Science Source Type: research

Application of Abbreviated Injury Scale and Injury Severity Score in Fatal Cases With Abdominopelvic Injuries
AbstractIn forensic casework, investigation of injury severity is important in evaluating the mortality, occasionally in terms of the adequacy of clinical management. The study was conducted with an objective to study the relationship of severity of the injuries using Abbreviated Injury Scale and Injury Severity Score (ISS) with survival period and place of death among fatal cases with abdominopelvic trauma.The total number of cases studied was 80. The injuries in all the body parts were allotted using the Abbreviated Injury Scale 2005, Update 2008, and the ISS was calculated. The male/female ratio was 4:1, and the mean (S...
Source: The American Journal of Forensic Medicine and Pathology - November 19, 2014 Category: Forensic Medicine Tags: Original Articles Source Type: research