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This page shows you the most recent publications within this specialty of the MedWorm directory.

Outcomes of expanded use of clinical pharmacist practitioners in addition to team-based care in a community health system intensive care unit.
CONCLUSION: With expanded CPP involvement on the NTICU team, there was a substantial increase in therapeutic optimization interventions and a clinically notable reduction in preventable ADEs, as well as an estimated 30% increase in associated cost savings. PMID: 25511838 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - December 19, 2014 Category: Drugs & Pharmacology Authors: Michalets E, Creger J, Shillinglaw WR Tags: Am J Health Syst Pharm Source Type: research

203: Intensive care admissions in pregnancy: analysis of a level of support scoring system
To apply the Maternal Critical Care Working Group level of support for critical care (MCCWG LOC) scoring to pregnant women admitted to an intensive care unit (ICU) to predict maternal outcomes and to compare it to the Acute Physiology and Chronic Health Evaluation (APACHE) II scoring system. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 19, 2014 Category: OBGYN Authors: Mili Thakur, Bernard Gonik, Navleen Gill, Awoniyi Awonuga, Frederico Rocha, Juan Gonzalez Tags: Poster session I Source Type: research

602: The impact of maternal obesity upon admission to neonatal intensive care
The objective of this investigation was to examine the potential association of maternal obesity and neonatal admission to intensive care. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 19, 2014 Category: OBGYN Authors: Allison Shannon, Myla Ebeling, Thomas Hulsey, Eugene Chang Tags: Poster session IV Source Type: research

793: Patterns of empiric antibiotic use for presumed early onset neonatal sepsis (EONS)
A difficult challenge of modern perinatology is the rapid and accurate diagnosis of EONS (first 72hrs after birth). In the absence of an accurate rapid diagnostic test neonates deemed at risk typically receive antibiotics in a neonatal intensive care unit (NICU). This practice of empirically treating at risk neonates leads to potentially harmful antibiotic exposure for many uninfected infants and adds significant financial pressure to an already prohibitively high health care system. To provide relevant information that can be used to optimize the effectiveness of NICU care, we aimed to determine the practice of antibiotic...
Source: American Journal of Obstetrics and Gynecology - December 19, 2014 Category: OBGYN Authors: Emily Oliver, Patricia Reagan, Jonathan Slaughter, Irina Buhimschi Tags: Poster session V Source Type: research

Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study
Publication date: Available online 18 December 2014 Source:The Lancet Respiratory Medicine Author(s): Anna Rautanen , Tara C Mills , Anthony C Gordon , Paula Hutton , Michael Steffens , Rosamond Nuamah , Jean-Daniel Chiche , Tom Parks , Stephen J Chapman , Emma E Davenport , Katherine S Elliott , Julian Bion , Peter Lichtner , Thomas Meitinger , Thomas F Wienker , Mark J Caulfield , Charles Mein , Frank Bloos , Ilona Bobek , Paolo Cotogni , Vladimir Sramek , Silver Sarapuu , Makbule Kobilay , V Marco Ranieri , Jordi Rello , Gonzalo Sirgo , Yoram G Weiss , Stefan Russwurm , E Marion Schneider , Konrad Reinhart , Paul A H ...
Source: The Lancet Respiratory Medicine - December 19, 2014 Category: Respiratory Medicine Source Type: research

Evaluation of the Impact of a Pertussis Cocooning Program on Infant Pertussis Infection
Conclusions:Postpartum immunization and cocooning did not reduce pertussis illness in infants ≤6 months of age. Efforts should be directed toward increasing tetanus, diphtheria and acellular pertussis immunization during pregnancy, combined with cocooning, to reduce life-threatening young infant pertussis. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - December 18, 2014 Category: Infectious Diseases Tags: Original Studies Source Type: research

Fluid Overload in Patients With Severe Sepsis and Septic Shock Treated With Early Goal-Directed Therapy Is Associated With Increased Acute Need for Fluid-Related Medical Interventions and Hospital Death
ABSTRACT: Early goal-directed therapy (EGDT) consists of early, aggressive fluid resuscitation and is known to improve survival in sepsis. It is unknown how often EGDT leads to subsequent fluid overload and whether post-EGDT fluid overload affects patients’ outcomes. Our hypothesis was that patients with sepsis treated with EGDT were at risk for fluid overload and that fluid overload would be associated with adverse outcomes. We conducted a retrospective cohort of 405 consecutive patients admitted with severe sepsis and septic shock to the medical intensive care unit of a tertiary care academic hospital from January 2008...
Source: Shock - December 18, 2014 Category: Emergency Medicine Tags: Clinical Aspects Source Type: research

The Impact of Serial Lactate Monitoring on Emergency Department Resuscitation Interventions and Clinical Outcomes in Severe Sepsis and Septic Shock: An Observational Cohort Study
ABSTRACT: Monitoring in the setting of critical illness must be linked to beneficial therapy to affect clinical outcome. Elevated serum lactate is associated with an increase in mortality in emergency department (ED) patients with severe sepsis and septic shock. The reduction of lactate levels toward normal during acute resuscitation is associated with improved clinical outcomes. The majority of data demonstrating the interventions used to achieve a reduction in lactate levels and the associated clinical outcomes have been obtained during protocolized randomized trials. We therefore conducted a retrospective observational ...
Source: Shock - December 18, 2014 Category: Emergency Medicine Tags: Clinical Aspects Source Type: research

Prophylactic versus reactive transfusion of thawed plasma in patients undergoing surgical repair of craniosynostosis: a randomized clinical trial
ConclusionA reactive FFP transfusion strategy required less plasma transfusion and was associated with similar rates of blood loss and PRBC transfusion as prophylactic FFP despite improvement in coagulation values in the prophylactic FFP group. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - December 18, 2014 Category: Anesthesiology Authors: Benjamin J. Pieters, Lisa Conley, Jennifer Weiford, Marilyn Hamilton, Brian Wicklund, Adam Booser, Adam Striker, Susan Whitney, Virender Singhal Tags: Original Article Source Type: research

Australia-wide point prevalence survey of the use and appropriateness of antimicrobial prescribing for children in hospital.
CONCLUSION: A point prevalence survey is a useful cross-sectional method for quantifying antimicrobial use in paediatric populations. The value is significantly augmented by adding assessment of prescribing quality. PMID: 25495311 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - December 18, 2014 Category: Journals (General) Tags: Med J Aust Source Type: research

Erratum to: Study of Ventilator-Associated Pneumonia in a Pediatric Intensive Care Unit
(Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - December 18, 2014 Category: Pediatrics Source Type: research

Evaluation of vestibulo-ocular reflex in patients with damage to the central nervous system (GCS score 5–3)
Conclusions The results of our study show the usefulness of performing the vestibulo-ocular test in patients with severe brain injury to predict their survival. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - December 18, 2014 Category: Biomedical Science Source Type: research

Fiscal Implications of Newborn Screening in the Diagnosis of Severe Combined Immunodeficiency
Publication date: November–December 2014 Source:The Journal of Allergy and Clinical Immunology: In Practice, Volume 2, Issue 6 Author(s): Catherine Kubiak , Soma Jyonouchi , Caroline Kuo , Maria Garcia-Lloret , Morna J. Dorsey , John Sleasman , Arthur S. Zbrozek , Elena E. Perez In the United States, newborn screening (NBS) is currently recommended for identification of 31 debilitating and potentially fatal conditions. However, individual states determine which of the recommended conditions are screened. The addition of severe combined immunodeficiency (SCID) screening to the recommended NBS panel has been fully instit...
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 18, 2014 Category: Allergy & Immunology Source Type: research

Prognosis of primary percutaneous coronary intervention in elderly patients with ST- elevation myocardial infarction
Conclusion PPCI has higher survival rate and compared to MT less comorbidity were observed in PPCI group in elderly patients presenting with STEMI. (Source: Journal of the Saudi Heart Association)
Source: Journal of the Saudi Heart Association - December 18, 2014 Category: Cardiology Source Type: research

Interactive simulator for e-Learning environments: a teaching software for health care professionals
There is an established tradition of cardiovascular simulation tools, but the application of this kind of technology in the e-Learning arena is a novel approach. This paper presents an e-Learning environment aimed at teaching the interaction of cardiovascular and lung systems to health-care professionals. Heart-lung interaction must be analyzed while assisting patients with severe respiratory problems or with heart failure in intensive care unit. Such patients can be assisted by mechanical ventilatory assistance or by thoracic artificial lung."In silico" cardiovascular simulator was experimented during a training course gi...
Source: BioMed Central - December 18, 2014 Category: Journals (General) Authors: Claudio De LazzariIgino GenuiniDomenico M PisanelliAlessandra D¿AmbrosiFrancesco Fedele Source Type: research

Nutritional care after critical illness: a qualitative study of patients’ experiences
ConclusionsThe findings from the present study provide a unique contribution to knowledge by offering important insights into patients’ experiences of eating after critical illness. The study has identified numerous nutritional problems and raises questions about the efficacy of current nutritional management in this patient group. Adopting a more individualised approach to nutritional care could ameliorate the nutritional issues experienced by post ICU patients. This will be evaluated in future work. (Source: Journal of Human Nutrition and Dietetics)
Source: Journal of Human Nutrition and Dietetics - December 18, 2014 Category: Nutrition Authors: J. L. Merriweather, L. G. Salisbury, T. S. Walsh, P. Smith Tags: Research Paper Source Type: research

Nonconvulsive Seizures in Children with Infection‐Related Altered Mental Status
ConclusionsApproximately one‐third of the children infected with influenza A(H1N1)pdm09 with altered mental status presented with NCS. Further research is needed to determine if the detection and management of NCS improve outcomes in these children. (Source: Pediatrics International)
Source: Pediatrics International - December 18, 2014 Category: Pediatrics Authors: Kyoko Fujita, Hiroaki Nagase, Taku Nakagawa, Yohsuke Saji, Azusa Maruyama, Yoshiyuki Uetani Tags: Original Article Source Type: research

Risk Factors for Requiring Intensive Care Among Children Admitted to Ward With Bronchiolitis
Conclusions In this multicenter study of children hospitalized with bronchiolitis, low birth weight and tachypnea were significantly associated with subsequent transfer to the ICU and/or use of mechanical ventilation. (Source: Academic Pediatrics)
Source: Academic Pediatrics - December 18, 2014 Category: Pediatrics Source Type: research

Angiotensin II: a new approach for refractory shock management?
Patients with distributive shock still have a high mortality rate and remain an important issue for intensivists. Management of catecholamine-resistant shock in these patients poses a challenging problem. Despite significant advances in the knowledge of its pathophysiology, all innovative therapeutic approaches and interventions have failed to improve outcome. In the previous issue of Critical Care, Chawla and colleagues explored the impact of angiotensin II administration in patients with persistent hypotension despite adapted hemodynamic resuscitation. The authors demonstrate that, in case of distributive shock, angioten...
Source: Critical Care - December 18, 2014 Category: Intensive Care Authors: Antoine KimmounBruno Levy Source Type: research

High Initial Tidal Volumes in ED Patients at Risk for Acute Respiratory Distress Syndrome
Emergency department (ED) patients are at high risk for the acute respiratory distress syndrome (ARDS). Settings only 1mL/kg above recommended tidal volumes confers harm for these patients. The purpose of this study was to determine whether ED physicians routinely initiate mechanical ventilation with low tidal volumes in patients at risk for ARDS. (Source: Journal of Critical Care)
Source: Journal of Critical Care - December 18, 2014 Category: Intensive Care Authors: Michael G. Allison, Michael C. Scott, Kami M. Hu, Michael D. Witting, Michael E. Winters Source Type: research

First plasma glucose value after urgent admission and in-hospital mortality in acutely decompensated heart failure
We used data from three (Source: Heart and Lung)
Source: Heart and Lung - December 18, 2014 Category: Intensive Care Authors: José M. de Miguel-Yanes, Concepción Gonzalo-Hernando, Nuria Muñoz-Rivas, Manuel Méndez-Bailón, Fernando Cava-Valenciano, Juan Torres-Macho Source Type: research

Is It Time to Reprioritize Our Research Focus in Critical Care Medicine? A Call for More Collaboration Between Cardiologists and Intensive Care Specialists*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 17, 2014 Category: Emergency Medicine Tags: Editorials Source Type: research

The Unmet Need for Addressing Cardiac Issues in Intensive Care Research*
Conclusions: These findings highlight the relative paucity of cardiac-specific research in the intensive care setting relative to the high prevalence of acute cardiac diseases and comorbidities. This observed disparity warrants timely attention and should lead to meaningful research opportunities aimed at improving the outcomes of critically ill cardiac patients. (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 17, 2014 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Pregnancy-Related ICU Admissions in France: Trends in Rate and Severity, 2006–2009*
Conclusions: The rate of women with pregnancy-related ICU admissions decreased and the severity of their cases increased. Most ICU admissions remained related to the least severe conditions. This raises the issue of the most appropriate organization of care for women with pregnancy-related conditions who require continuous surveillance but not necessarily intensive care. (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 17, 2014 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Influence of n-3 Polyunsaturated Fatty Acids Enriched Lipid Emulsions on Nosocomial Infections and Clinical Outcomes in Critically Ill Patients: ICU Lipids Study*
Conclusions: The results show that administration of n-3 polyunsaturated fatty acids reduces the risk of nosocomial infections and increases the predicted time free of infections in critically ill medical and surgical patients. The administration of n-3 polyunsaturated fatty acids was safe and well tolerated. (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 17, 2014 Category: Emergency Medicine Tags: Feature Articles Source Type: research

Surviving Sepsis Campaign: Association Between Performance Metrics and Outcomes in a 7.5-Year Study
Conclusions: This analysis demonstrates that increased compliance with sepsis performance bundles was associated with a 25% relative risk reduction in mortality rate. Every 10% increase in compliance and additional quarter of participation in the SSC initiative was associated with a significant decrease in the odds ratio for hospital mortality. These results demonstrate that performance metrics can drive change in clinical behavior, improve quality of care, and may decrease mortality in patients with severe sepsis and septic shock. (Source: Critical Care Medicine)
Source: Critical Care Medicine - December 17, 2014 Category: Emergency Medicine Tags: Special Article Source Type: research

Unpredictable drug reaction in a child with Cornelia de Lange syndrome
Conclusion In our opinion midazolam should be avoided in patients with Cornelia de Lange Syndrome, which we enforced after first unpredictable reaction. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 17, 2014 Category: Drugs & Pharmacology Source Type: research

Successful treatment of aortogastric fistula after esophagectomy
We report a case of an aortogastric fistula due to a peptic ulcer after esophagectomy for esophageal carcinoma, in which treatment with surgery and endovascular stent graft repair was successful. A 67-year-old woman underwent esophagectomy for esophageal carcinoma and reconstruction with a gastric tube through the posterior mediastinal route. Eleven years later, she experienced massive hematemesis and severe shock due to an aortogastric fistula, although there was no evidence of cancer recurrence. The fistula was obliterated surgically and the perforated aorta was directly closed. However, a pseudoaneurysm located at the c...
Source: Esophagus - December 17, 2014 Category: Gastroenterology Source Type: research

Improved nutrient intake following implementation of the consensus standardised parenteral nutrition formulations in preterm neonates ¿ a before-after intervention study
Conclusions: New consensus SPN solutions provided better protein intake in the first 7?days and were associated with greater weight gain in the first 4?weeks. However, protein intake on day 1 was below the consensus goal of 2?g/kg/day. (Source: BMC Pediatrics)
Source: BMC Pediatrics - December 17, 2014 Category: Pediatrics Authors: Srinivas BolisettyPramod PharandeLakshman NirthanakumaranTimothy DoDavid OsbornJohn SmythJohn SinnKei Lui Source Type: research

Palliative Care in the Cardiac Intensive Care Unit
This study examined all admissions to the Mount Sinai Hospital CICU from Jan 1 through Dec 31, 2012. Of the 1,368 patients admitted, there were 117 CICU patient deaths. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - December 17, 2014 Category: Cardiology Authors: Tara Naib, Sopan Lahewala, Shilpkumar Arora, Umesh Gidwani Source Type: research

Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial
Publication date: Available online 17 December 2014 Source:The Lancet Respiratory Medicine Author(s): Jennifer G Wilson , Kathleen D Liu , Hanjing Zhuo , Lizette Caballero , Melanie McMillan , Xiaohui Fang , Katherine Cosgrove , Rosemary Vojnik , Carolyn S Calfee , Jae-Woo Lee , Angela J Rogers , Joseph Levitt , Jeanine Wiener-Kronish , Ednan K Bajwa , Andrew Leavitt , David McKenna , B Taylor Thompson , Michael A Matthay Background No effective pharmacotherapy for acute respiratory distress syndrome (ARDS) exists, and mortality remains high. Preclinical studies support the efficacy of mesenchymal stem (stromal) cells (M...
Source: The Lancet Respiratory Medicine - December 17, 2014 Category: Respiratory Medicine Source Type: research

Impact of Pathogen-Directed Antimicrobial Therapy for Ventilator-Associated Pneumonia in Trauma Patients on Charges and Recurrence
Ventilator-associated pneumonia (VAP) represents one of the driving forces behind antibiotic usage in the intensive care unit. In a previous study (PS), we established a defined algorithm for treatment of hospital-acquired VAP dictated by the causative pathogen. The purpose of the current study (CS) was to evaluate the impact of this algorithm for hospital-acquired VAP on recurrence and charges in trauma patients. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - December 17, 2014 Category: Surgery Authors: John P. Sharpe, Louis J. Magnotti, Jordan A. Weinberg, Joseph M. Swanson, G Christopher Wood, Timothy C. Fabian, Martin A. Croce Source Type: research

Prehospital treatment of sepsis: what really makes the ¿golden hour¿ golden?
The early recognition of severe sepsis is important; however, early identification of severe sepsis can be challenging, especially in the prehospital setting. As previous research has shown, advanced notification of time-sensitive disease states by prehospital personnel can improve outcomes and time to initiation of treatments. Prehospital personnel can potentially impact outcomes in sepsis through early identification and treatment implementations, improving processes of care and transition of care. Further research is needed for a full evaluation of prehospital treatment effects of identification of sepsis and treatment ...
Source: Critical Care - December 17, 2014 Category: Intensive Care Authors: Sarah SterlingMichael PuskarichAlan Jones Source Type: research

N-Terminal pro-Brain Natriuretic Peptide and Cardiac Troponin I for the Prognostic Utility in Elderly Patients with Severe Sepsis or Septic Shock in Intensive Care Unit: a Retrospective Study
Using biomarkers to predict mortality in patient with severe sepsis or septic shock is of importance, as these patients frequently have high mortality and unsatisfied outcome. N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac Troponin I (cTnI) play extremely important roles in prognostic value in the mortality of severe sepsis and septic shock. (Source: Journal of Critical Care)
Source: Journal of Critical Care - December 17, 2014 Category: Intensive Care Authors: Hui Cheng, Wei-Ze Fan, Sheng-Chi Wang, Zhao-Hui Liu, Hui-Ling Zang, Li-Zhong Wang, Hong-Juan Liu, Xiao-Hui Shen, Shao-Qing Liang Source Type: research

Impact of Obesity on Sepsis Mortality: A Systematic review
Sepsis and severe sepsis are the most common cause of death among critically ill patients admitted in non-coronary intensive care units. As over one-third of the adult population of the United States is obese; we undertook a systematic review of the association between obesity and mortality among patients admitted with sepsis, severe sepsis or septic shock. (Source: Journal of Critical Care)
Source: Journal of Critical Care - December 17, 2014 Category: Intensive Care Authors: Vrinda Trivedi, Chirag Bavishi, Raymonde Jean Source Type: research

End-of-Life Care in the Neonatal Intensive Care Unit: Experiences of Staff and Parents
Conclusion End-of-life experiences in the NICU were perceived as variable and end-of-life practices were, at times, perceived as inconsistent among providers. There are areas for improvement, and participants reported that a formalized palliative care team could help. Families desire memory making, follow-up, and bereavement support.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - December 17, 2014 Category: Perinatology & Neonatology Authors: Cortezzo, DonnaMaria E.Sanders, Marilyn R.Brownell, Elizabeth A.Moss, Kerry Tags: Original Article Source Type: research

Amplitude-Integrated Electroencephalography: A Survey of Practices in the United States
Conclusion More than half of neonatologists utilize aEEG, with practice variation by NICU setting. Barriers to wider adoption include education regarding potential benefit, training, and cost.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - December 17, 2014 Category: Perinatology & Neonatology Authors: Shah, Nidhi A.Van Meurs, Krisa P.Davis, Alexis S. Tags: Original Article Source Type: research

Urinary Tract Infections in a Neonatal Intensive Care Unit
Conclusion Renal pelvis dilation was common but not associated with reflux among NICU patients diagnosed with UTI. Diagnostic criteria in this population are not well defined, and guidelines are needed for diagnosis and management of UTIs in NICU patients.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - December 17, 2014 Category: Perinatology & Neonatology Authors: Weems, Mark F.Wei, DanielRamanathan, RangasamyBarton, LorayneVachon, LindaSardesai, Smeeta Tags: Original Article Source Type: research

Complexity of heart rate variability predicts outcome in intensive care unit admitted patients with acute stroke
Conclusions In ICU-admitted patients with acute stroke, early assessment of the complexity of HRV by MSE can help in predicting outcomes in patients without AF. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 17, 2014 Category: Neurosurgery Authors: Tang, S.-C., Jen, H.-I., Lin, Y.-H., Hung, C.-S., Jou, W.-J., Huang, P.-W., Shieh, J.-S., Ho, Y.-L., Lai, D.-M., Wu, A.-Y., Jeng, J.-S., Chen, M.-F. Tags: Stroke Cerebrovascular disease Source Type: research

Acute appearance of a carotid pseudoaneurysm during coughing
An adolescent with Behçet's disease presented after an episode of violent coughing with the sudden appearance of a pulsatile mass on his neck (figure 1A). Since childhood, he had been treated with a coumarin derivative (international normalised ratio at admission: 3.2) after cavernous sinus thrombosis and detection of heterozygous mutations in the prothrombin and homocysteine genes. Neurological examination was unremarkable except for mild hoarseness. Imaging revealed a pseudoaneurysm with common carotid artery dissection (figure 1B, C). Two stents were placed. On follow-up, there was no detectable aneurysm. Beh&cce...
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 17, 2014 Category: Neurosurgery Authors: Enamorado, J. E., Witsch, J., Aviles, A. H., Perez, R. H. Tags: Genetics, Neurological injury, Stroke, Trauma CNS / PNS, Ophthalmology, Radiology, Adult intensive care, Vascularitis, Radiology (diagnostics), Ear, nose and throat/otolaryngology, Trauma, Injury Neurological pictures Source Type: research

Prognosis of critically Ill cirrhotic versus noncirrhotic patients: a comprehensive score-matched study
Conclusions: Score-matched analytical data showed that the SOFA scores significantly differentiated the patients admitted to the ICU with cirrhosis from those without cirrhosis in APACHE III-matched groups, whereas difference in the APACHE III scores between the patients with and without cirrhosis were nonsignificant in the SOFA-matched group. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - December 17, 2014 Category: Anesthesiology Authors: Chung-Ming FuChih-Hsiang ChangPei-Chun FanMing-Hung TsaiShu-Min LinKuo-Chin KaoYa-Chung TianCheng-Chieh HungJi-Tseng FangChih-Wei YangYung-Chang Chen Source Type: research

Diagnosis and antimicrobial therapy of lung infiltrates in febrile neutropenic patients (allogeneic SCT excluded): updated guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)
Up to 25% of patients with profound neutropenia lasting for >10 days develop lung infiltrates, which frequently do not respond to broad-spectrum antibacterial therapy. While a causative pathogen remains undetected in the majority of cases, Aspergillus spp., Pneumocystis jirovecii, multi-resistant Gram-negative pathogens, mycobacteria or respiratory viruses may be involved. In at-risk patients who have received trimethoprim–sulfamethoxazole (TMP/SMX) prophylaxis, filamentous fungal pathogens appear to be predominant, yet commonly not proven at the time of treatment initiation. Pathogens isolated from blood cultures...
Source: Annals of Oncology - December 17, 2014 Category: Cancer & Oncology Authors: Maschmeyer, G., Carratala, J., Buchheidt, D., Hamprecht, A., Heussel, C. P., Kahl, C., Lorenz, J., Neumann, S., Rieger, C., Ruhnke, M., Salwender, H., Schmidt-Hieber, M., Azoulay, E. Tags: reviews Source Type: research

The impact of hospital acquired infections with multidrug-resistant bacterial at an oncological intensive care unit
(Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - December 17, 2014 Category: Infectious Diseases Authors: P Cornejo-Juárez, D Vilar-Compte, C Pérez-Jiménez, SA Ñamendys-Silva, S Sandoval-Hernández, P Volkow-Fernández Source Type: research

Exploring intensive care nurses¿ team performance in a simulation-based emergency situation, ¿ expert raters¿ assessments versus self-assessments: an explorative study
Conclusions: Teams of registered nurses representing specialties with coronary patients exhibit a higher competence in non-technical skills compared to team performance regarding a simulated cardiac arrest. The use of expert raters? assessments and registered nurses? self-assessments are useful in raising awareness of team performance with regard to patient safety. (Source: BMC Nursing)
Source: BMC Nursing - December 17, 2014 Category: Nursing Authors: Randi BallangrudMona PerseniusBirgitta HedelinMarie Hall-Lord Source Type: research

Obstetric and gynecological admissions to the intensive care unit at Khartoum Hospital, Sudan
Indications for admission to the intensive care unit (ICU) are numerous, and high mortality rates among such patients are found in low-resource countries [1–3]. Few published data exist on ICU admission in African countries, including Sudan. The aim of the present study was to investigate the causes of admission to the ICU among obstetric and gynecological patients and their outcomes from January 1 to December 31, 2012, at Khartoum Hospital, Sudan. The study received ethical approval from the Research and Ethics Committee of Khartoum University. (Source: International Journal of Gynaecology and Obstetrics)
Source: International Journal of Gynaecology and Obstetrics - December 17, 2014 Category: OBGYN Authors: Ibrahim A. Ibrahim, Duria A. Rayis, Mohamed A. Alsammani, Ishag Adam Tags: Brief communication Source Type: research

Circuit Life Versus Bleeding Risk: The Impact of Achieved Activated Partial Thromboplastin Time Versus Achieved Filtration Fraction
Abstract Whilst prolonging hemofilter (circuit) life, heparin increases bleeding risk. The impact of achieved activated partial thromboplastin time (APTT) on circuit life and bleeding risk has not been assessed in a modern critically ill cohort. Lowering filtration fraction may be an alternative means of prolonging circuit life, but is often overlooked in critical care. An observational study of 309 consecutive circuits in a general intensive care unit was conducted using a wide target APTT range. Multilevel modeling was used to predict circuit life and bleeding according to achieved APTT and filtration fraction. Independe...
Source: Therapeutic Apheresis and Dialysis - December 16, 2014 Category: Hematology Authors: Clare MacEwen, Peter Watkinson, Christopher Winearls Tags: Original Article Source Type: research

Accuracy of Power Mode Transcranial Doppler in the Diagnosis of Brain Death
Conclusion PMD-TCD is accurate for the diagnosis of BD. (Source: Journal of Medical Ultrasound)
Source: Journal of Medical Ultrasound - December 16, 2014 Category: Radiology Source Type: research

Cronobacter, the emergent bacterial pathogen Enterobacter sakazakii comes of age; MLST and whole genome sequence analysis
Conclusions: The Cronobacter PubMLST database offers a central, open access, reliable sequence-based repository for researchers. It has the capacity to create new analysis schemes 'on the fly', and to integrate metadata (source, geographic distribution, clinical presentation). It is also expandable and adaptable to changes in taxonomy, and able to support the development of reliable detection methods of use to industry and regulatory authorities. Therefore it meets the WHO (2004) request for the establishment of a typing scheme for this emergent bacterial pathogen. Whole genome sequencing has additionally shown a range of ...
Source: BMC Genomics - December 16, 2014 Category: Genetics & Stem Cells Authors: Stephen ForsytheBenjamin DickinsKeith Jolley Source Type: research