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Intensive Care

This page shows you the most recent publications within this specialty of the MedWorm directory.

[Electroconvulsion therapy for neuroleptic malignant syndrome].
Abstract A 64-year-old man, diagnosed with recurrent depression, developed a neuroleptic malignant syndrome (nms) during treatment with olanzapine and mirtazapine. Psychotropic drugs were discontinued. Supportive therapy in an intensive care setting was initiated and electroconvulsive therapy (ect) was administered, after which the patient recovered. This case report discusses the place of ect in the treatment of nms. PMID: 25222100 [PubMed - in process] (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - September 19, 2014 Category: Psychiatry Authors: Buggenhout S, Vandenberghe J, Sienaert P Tags: Tijdschr Psychiatr Source Type: research

Determinants of mortality, intensive care requirement and prolonged hospitalization in malaria - a tertiary care hospital based cohort study from South-Western India
The paper deals with the important topic of determinants of severe malaria. (Source: Malaria Journal)
Source: Malaria Journal - September 19, 2014 Category: Infectious Diseases Authors: Kavitha SaravuKumar RishikeshAsha Kamath Source Type: research

Demographics, clinical characteristics and neonatal outcomes in a rural Ugandan NICU
Background: Ninety-six percent of the world's 3 million neonatal deaths occur in developing countries where the majority of births occur outside of a facility. Community-based approaches to the identification and management of neonatal illness have reduced neonatal mortality over the last decade. To further expand life-saving services, improvements in access to quality facility-based neonatal care are required. Evaluation of rural neonatal intensive care unit referral centers provides opportunities to further understand determinants of neonatal mortality in developing countries. Our objective was to describe demographics, ...
Source: BMC Pregnancy and Childbirth - Latest articles - September 19, 2014 Category: OBGYN Authors: Anna HedstromTove RymanChristine OtaiJames NyonyintonoRyan McAdamsDeborah LesterManeesh Batra Source Type: research

From high risk to low risk, WakeMed says it has services to meet all pregnancies
When the freestanding birthing center in Cary opens in October, it will broaden WakeMed’s bookends on its continuum of pregnancy and baby care. WakeMed Health & Hospitals partnered with Baby+Company to open a freestanding birth center in Cary, which offers new mothers with low-risk pregnancies an alternative to a hospital birth. Read: WakeMed to open freestanding birthing center with Baby+Co Already, WakeMed has an impressive neonatal intensive care unit, which provides developmentally supportive… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - September 18, 2014 Category: Biotechnology Authors: Jason deBruyn Source Type: research

From high risk to low risk, WakeMed says it has services to meet all pregnancies
When the freestanding birthing center in Cary opens in October, it will broaden WakeMed’s bookends on its continuum of pregnancy and baby care. WakeMed Health & Hospitals partnered with Baby+Company to open a freestanding birth center in Cary, which offers new mothers with low-risk pregnancies an alternative to a hospital birth. Read: WakeMed to open freestanding birthing center with Baby+Co Already, WakeMed has an impressive neonatal intensive care unit, which provides developmentally supportive… (Source: bizjournals.com Health Care:Hospitals headlines)
Source: bizjournals.com Health Care:Hospitals headlines - September 18, 2014 Category: Hospital Management Authors: Jason deBruyn Source Type: research

In-hospital Clinical Outcomes of the Oldest-old Patients Over 90 Years Old with Acute Heart Failure
A total of 720 consecutive patients with acute heart failure (AHF) admitted to our intensive care unit between January 2009 and June 2013 were enrolled. The in-hospital mortality was compared between the oldest-old group (group-A: >90 years old, 84 patients, 11.7%, 93.5 ± 3.5 years) and the younger group (group-B: 70.3 ± 12.4 years). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 18, 2014 Category: Cardiology Authors: Tetsuo Yamaguchi, Noriko Watanabe, Takamichi Miyamoto, Toru Obayashi, Mitsuaki Isobe Source Type: research

Importance of Aortic Valve Opening Under Percutaneous Cardiopulmonary Support (PCPS) in Patients with Fulminant Myocarditis; from the 2 Distinctive Cases
A 48-year-old male, who was diagnosed as fulminant myocarditis was transferred to the intensive-care unit in our hospital. Echocardiography showed progressive decline of left ventricular function after admission. The 2nd day, intraaortic balloon pumping (IABP) and PCPS were introduced due to cardiogenic shock. Under cardiopulmonary support, we paid careful attention to keeping aortic valve open in systole to prevent thromboembolic complications. After 10 days of cardiopulmonary support, his cardiac function improved gradually and he weaned from IABP and PCPS. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - September 18, 2014 Category: Cardiology Authors: Masao Yamaguchi, Taro Sasaoka, Kensuke Hirasawa, Mie Seya, Syunji Yoshikawa, Yasuhiro Maejima, Masahiko Goya, Takashi Ashikaga, Kenzo Hirao, Mitsuaki Isobe Source Type: research

Traditional landmark versus ultrasound guided tracheal puncture during percutaneous dilatational tracheostomy in adult intensive care patients: a randomised controlled trial
Conclusions: Ultrasound guidance significantly improved the rate of first-pass puncture and puncture accuracy. Fewer procedural complications were observed however this did not reach statistical significance. These results support wider general use of real-time ultrasound guidance as an additional tool to improve PDT.Trial registrationAustralia and New Zealand Clinical Trials Registry ACTRN12611000237987, registered 04 March 2011 (Source: Critical Care)
Source: Critical Care - September 18, 2014 Category: Intensive Care Authors: Máté RudasIan SeppeltRobert HerkesRobert HislopDorrilyn RajbhandariLeonie Weisbrodt Source Type: research

Intraoperative bispectral index monitoring and time to extubation after cardiac surgery: secondary analysis of a randomized controlled trial
Conclusions: The use of intraoperative BIS monitoring during cardiac surgery did not change time to extubation, ICU length of stay or hospital length of stay. Data regarding BIS monitoring and recovery in an exclusively cardiac surgery population are consistent with recent effectiveness studies in the general surgical population.Trial registration: ClinicalTrials.gov number NCT00689091. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - September 18, 2014 Category: Epidemiology Authors: Jennifer L VanceAmy M ShanksDerek T Woodrum Source Type: research

Selective decontamination of the digestive tract: time to implement it in all UK intensive care units? Maybe not yet
(Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - September 18, 2014 Category: Anesthesiology Authors: Philips, B. J. Tags: Editorials Source Type: research

5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: protocol, methods, and analysis of data
Conclusions The NAP5 methodology may be used to assess new reports of AAGA in a standardized manner, especially for the development of an ongoing database of case reporting. This paper is a shortened version describing the protocols, methods, and data analysis from NAP5—the full report can be found at http://www.nationalauditprojects.org.uk/NAP5_home. (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - September 18, 2014 Category: Anesthesiology Authors: Pandit, J. J., Andrade, J., Bogod, D. G., Hitchman, J. M., Jonker, W. R., Lucas, N., Mackay, J. H., Nimmo, A. F., O'Connor, K., O'Sullivan, E. P., Paul, R. G., Palmer, J. H. M., Plaat, F., Radcliffe, J. J., Sury, M. R. J., Torevell, H. E., Wang, M., Cook, Tags: Special Articles Source Type: research

Observational study of current use of selective decontamination of the digestive tract in UK Critical Care units
Conclusions Use of SDD in UK critical care is very low. The rate of unit-acquired infections in blood was significantly lower in SDD units using an i.v. component, but did not translate into a difference in acute hospital mortality or length of stay. There is a need to better understand the barriers to adoption of SDD into clinical practice and such work is underway. (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - September 18, 2014 Category: Anesthesiology Authors: Canter, R. R., Harvey, S. E., Harrison, D. A., Campbell, M. K., Rowan, K. M., Cuthbertson, B. H., Duncan, Prior, Bellingan, Campbell, Eccles, Johnston, MacLennan, Ramsay, Rose, Rowan, Shulman, Dombromski, Cuthbertson, [on behalf of the Selective Decontami Tags: Critical Care Source Type: research

Risk factors for obstetric morbidity in patients with uterine atony undergoing Caesarean delivery
Conclusions Among patients with UA undergoing Caesarean delivery, the risk of haemorrhage-related morbidity is increased in African-Americans, Hispanics, patients with multiple gestations, placenta praevia, ASA class III or IV, ≥2 prior Caesarean deliveries and those undergoing GA. (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - September 18, 2014 Category: Anesthesiology Authors: Butwick, A. J., Carvalho, B., El-Sayed, Y. Y. Tags: Obstetrics Source Type: research

Influence of intensive care treatment on the protein binding of sufentanil and hydromorphone during pain therapy in postoperative cardiac surgery patients
Conclusions Sufentanil protein binding was significantly dependent on changes in the total drug concentration and volume balance addressing the importance of adequate dosing and fluid-guided therapy. Hydromorphone protein binding was nearly constant throughout the study period. Clinical trial registration EudraCT 2011-003648-31 and ClinicalTrials.gov: NCT01490268. (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - September 18, 2014 Category: Anesthesiology Authors: Saari, T. I., Ihmsen, H., Mell, J., Frohlich, K., Fechner, J., Schuttler, J., Jeleazcov, C. Tags: Pain Source Type: research

Does diagnosis influence end-of-life decisions in the neonatal intensive care unit?
Does diagnosis influence end-of-life decisions in the neonatal intensive care unit? Journal of Perinatology advance online publication, September 18 2014. doi:10.1038/jp.2014.170 Authors: J Weiner, J Sharma, J Lantos & H Kilbride (Source: Journal of Perinatology)
Source: Journal of Perinatology - September 18, 2014 Category: Perinatology & Neonatology Authors: J WeinerJ SharmaJ LantosH Kilbride Source Type: research

Shades of grey
Last year I cared for Jamesi, an infant who had been born extremely prematurely. James was very sick in the first week or two of life, but had recovered and convalesced over the ensuing months. He was due to be discharged from hospital in the near future. One morning, when the medical team came to his bedside to review him, we found that he unexpectedly looked extremely unwell and was having difficulty breathing. Only half an hour previously he had seemed fine. James was whisked to the intensive care unit. He was intubated, resuscitated aggressively and received broad-spectrum antibiotics. Later that morning X-rays reveale...
Source: Journal of Medical Ethics - September 18, 2014 Category: Medical Ethics Authors: Wilkinson, D. J. C. Tags: Child health, Hospice, Transplantation, Artificial and donated transplantation, Informed consent, Legal and forensic medicine Clinical ethics Source Type: research

[From fishing trip to the critical care unit : Successful resuscitation after a near drowning accident.]
DISCUSSION: Section 8 of the ERC guidelines provides additional information for resuscitation under specific conditions. In this case report, hypothermia was one of the main criteria leading to an adjusted pharmacological therapy. Furthermore, selection of the appropriate hospital for an optimal advanced treatment including controlled warming of the patient and management of hypothermia-induced complications had to be evaluated. PMID: 25227882 [PubMed - as supplied by publisher] (Source: Der Anaesthesist)
Source: Der Anaesthesist - September 18, 2014 Category: Anesthesiology Authors: Kippnich M, Keller D, Jokinen J, Kilgenstein C, Muellenbach RM, Markus C, Roewer N, Kranke P Tags: Anaesthesist Source Type: research

Family‐centred care and traumatic symptoms in parents of children admitted to PICU
ConclusionThe fathers and mothers were very pleased with the perceived care at the unit. The experienced care was positively associated with acute stress, but not with illness severity, or fear of losing the child. More research is needed to understand the dynamics of family‐centred care. (Source: Scandinavian Journal of Caring Sciences)
Source: Scandinavian Journal of Caring Sciences - September 18, 2014 Category: Nursing Authors: Jesper Mortensen, Birgitte Olesen Simonsen, Sara Bek Eriksen, Pernille Skovby, Rolf Dall, Ask Elklit Tags: Empirical Studies Source Type: research

[Correspondence] Sepsis-associated encephalopathy versus sepsis-induced encephalopathy
We read with interest the Review by Widmann and Heneka on the long-term consequences of sepsis. Sepsis and its associated complications are thought to be the foremost causes of morbidity and mortality in patients in intensive-care units (ICU) worldwide. Sepsis, a potentially fatal sequel to infection, results from a cascade of pro-inflammatory compounds released in response to infection. Consequently, multiple-organ systems might be affected, leading to their failure. (Source: Lancet Neurology)
Source: Lancet Neurology - September 16, 2014 Category: Neurology Authors: Samad EJ Golzari, Ata Mahmoodpoor Tags: Correspondence Source Type: research

Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture
Conclusions: Based on the studies in eNOS mice, we conclude that the lack of endothelial nitric oxide production, on its own, may be sufficient to markedly exacerbate the severity of septic shock. Aging markedly worsens the degree of endothelial dysfunction in sepsis, yielding a significant worsening of the overall outcome. Thus, endothelial dysfunction may constitute an early predictor and independent contributor to sepsis-associated MODS and mortality in aged mice. (Source: Critical Care)
Source: Critical Care - September 16, 2014 Category: Intensive Care Authors: Ciro ColettaKatalin MódisGábor OláhAttila BrunyánszkiDaniela HerzigEdward SherwoodZoltán UngváriCsaba Szabo Source Type: research

Efficacy of dexmedetomidine for the control of junctional ectopic tachycardia after repair of tetralogy of Fallot
Conclusion: DEX had a therapeutic role in the prevention of junctional ectopic tachycardia in patients undergoing repair for TOF. (Source: Annals of Pediatric Cardiology)
Source: Annals of Pediatric Cardiology - September 16, 2014 Category: Cardiology Authors: Randhir S RajputSambhunath DasNeeti MakhijaBalram Airan Source Type: research

THERM: the Resuscitation Management score. A prognostic tool to identify critically ill patients in the emergency department
Conclusions PEDS is at least as good as other scores, including NEWS. However, it is unwieldy and relies on results not immediately accessible in the ED. THERM is a new score, derived and validated in an ED setting, using variables readily available, and simple to calculate and stratify. THERM outperforms NEWS and could be used in preference in critically ill ED patients. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - September 16, 2014 Category: Emergency Medicine Authors: Cattermole, G. N., Liow, E. C. H., Graham, C. A., Rainer, T. H. Tags: Resuscitation Original article Source Type: research

Effect of elevated serum alcohol level on the outcome of severely injured patients
Conclusions Severely injured patients with a raised BAL have a higher incidence of severe traumatic brain injury and worse initial physiological parameters. However, the survival rate and in-hospital stay is not influenced. This supports the theory of a neuroprotective role of alcohol. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - September 16, 2014 Category: Emergency Medicine Authors: Scheyerer, M. J., Dutschler, J., Billeter, A., Zimmermann, S. M., Sprengel, K., Werner, C. M. L., Simmen, H.-P., Wanner, G. A. Tags: Coma and raised intracranial pressure, Stroke, Trauma CNS / PNS, Hypertension, Adult intensive care, Trauma Original article Source Type: research

Outcomes after surgery in patients with previous stroke
ConclusionPatients with previous stroke had a higher risk of adverse postoperative outcomes; their 30‐day in‐hospital mortality rate was nearly twice that of patients without previous stroke. (Source: British Journal of Surgery)
Source: British Journal of Surgery - September 16, 2014 Category: Surgery Authors: C. C. Liao, P. Y. Chang, C. C. Yeh, C. J. Hu, C. H. Wu, T. L. Chen Tags: Original article Source Type: research

Burnout in the NICU setting and its relation to safety culture
Conclusions NICU caregiver burnout appears to have ‘climate-like’ features, is prevalent, and associated with lower perceptions of patient safety culture. (Source: Quality and Safety in Health Care)
Source: Quality and Safety in Health Care - September 16, 2014 Category: Health Management Authors: Profit, J., Sharek, P. J., Amspoker, A. B., Kowalkowski, M. A., Nisbet, C. C., Thomas, E. J., Chadwick, W. A., Sexton, J. B. Tags: Original research Source Type: research

Exposure to Leadership WalkRounds in neonatal intensive care units is associated with a better patient safety culture and less caregiver burnout
Conclusions WR are linked to patient safety and burnout. In NICUs, where they occurred more often, the workplace appears to be a better place to deliver and to receive care. (Source: Quality and Safety in Health Care)
Source: Quality and Safety in Health Care - September 16, 2014 Category: Health Management Authors: Sexton, J. B., Sharek, P. J., Thomas, E. J., Gould, J. B., Nisbet, C. C., Amspoker, A. B., Kowalkowski, M. A., Schwendimann, R., Profit, J. Tags: Original research Source Type: research

Influence of early goal-directed therapy using arterial waveform analysis on major complications after high-risk abdominal surgery: study protocol for a multicenter randomized controlled superiority trial
DiscussionBefore the start of the study, hemodynamic optimization by early goal-directed therapy with arterial waveform analysis had only been investigated in small, single-center studies, including minor complications as primary endpoint. Moreover, these studies did not include quality of life, healthcare costs, and long-term outcome in their analysis. As a result, the definitive role of arterial waveform analysis in the perioperative hemodynamic assessment and care for high-risk surgical patients is unknown, which gave rise to the present trial. Patient inclusion started in May 2012 and is expected to end in 2016.Trial r...
Source: Trials - September 16, 2014 Category: Journals (General) Authors: Leonard MontenijEric de WaalMichael FrankPaul van BeestArdine de WitCas KruitwagenWolfgang BuhreThomas Scheeren Source Type: research

Cost Savings of Universal Decolonization to Prevent Intensive Care Unit Infection: Implications of the REDUCE MRSA Trial
Infection Control and Hospital Epidemiology, Volume 35, Issue S3, Page S23-S31, October 2014. (Source: Infect Control Hosp Epidemiol Latest Issue)
Source: Infect Control Hosp Epidemiol Latest Issue - September 15, 2014 Category: Epidemiology Tags: article Source Type: research

Does Chlorhexidine Bathing in Adult Intensive Care Units Reduce Blood Culture Contamination? A Pragmatic Cluster-Randomized Trial
Infection Control and Hospital Epidemiology, Volume 35, Issue S3, Page S17-S22, October 2014. (Source: Infect Control Hosp Epidemiol Latest Issue)
Source: Infect Control Hosp Epidemiol Latest Issue - September 15, 2014 Category: Epidemiology Tags: article Source Type: research

Anthropometric indicators of nutritional status and growth in very low birth-weight premature infants hospitalized in a neonatal intensive care unit.
Conclusion: Weight/age in the VLBW/AGA premature infants could reflect growth, nutritional status and energy stored as fat, but in the VLBW/SGA premature infants, thigh circumference and mid arm circumference would be better indicators just of nutritional status. PMID: 25208797 [PubMed - as supplied by publisher] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - September 15, 2014 Category: Nutrition Authors: Vásquez-Garibay EM, Larios Del Toro YE, Larrosa-Haro A, Troyo-Sanromán R Tags: Nutr Hosp Source Type: research

Healthcare professionals may not be maintaining person-centred care for people with dementia hospitalised on acute wards
Commentary on: Clissett P, Porock D, Harwood RH, et al.. The challenges of achieving person-centred care in acute hospitals: a qualitative study of people with dementia and their families. Int J Nurs Stud 2013;50:1495–503. Implications for practice and research Healthcare professionals in acute care require additional education to implement person-centred care of persons with dementia. Person-centred care in hospital settings can be enhanced through the promotion of attachment, inclusion, identity, occupation and comfort. Organisational factors, such as productivity goals, may influence the implementation of person-c...
Source: Evidence-Based Nursing - September 15, 2014 Category: Nursing Authors: Gaugler, J. E., Wocken, K. M. Tags: Long term care, Care of the older person, Dementia, Memory disorders (psychiatry), Adult intensive care, Screening (public health) Source Type: research

Therapeutic drug monitoring: linezolid too?
Numerous factors interfere with the ability to achieve optimal pharmacokinetic and pharmacodynamic targets and this has been associated with greater mortality and lower cure rates. The recent study by Zoller and colleagues examining linezolid levels in critically ill patients emphasises this point. Their study is unique in the description of the intra-patient and inter-patient variability that occurs and in the degree to which therapy is inadequate; 63% of patients had insufficient levels and only 17% maintained optimal trough values (between 2 and 10 mg/l) throughout the 4 study days. Precisely why this result occurred i...
Source: Critical Care - September 15, 2014 Category: Intensive Care Authors: Guy RichardsAdrian Brink Source Type: research

Efficacy and bleeding risk of antithrombin supplementation in septic disseminated intravascular coagulation: a secondary survey
Conclusion: The AT3000 group exhibited significantly improved rates of survival and recovery from DIC without an increased risk of bleeding, compared with the AT1500 group, among the patients with sepsis-associated DIC and an AT activity (Source: Critical Care)
Source: Critical Care - September 15, 2014 Category: Intensive Care Authors: Toshiaki IbaDaizoh SaitohHideo WadaHidesaku Asakura Source Type: research

Frontal electroencephalogram variables are associated with the outcome and stage of hepatic encephalopathy in acute liver failure
In conclusion, EEG variables are useful for the monitoring of HE and can be used to predict outcomes of ALF. TCD measurements do not predict patient outcomes. Liver Transpl, 2014. © 2014 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - September 15, 2014 Category: Transplant Surgery Authors: Juhani Stewart, Mika Särkelä, Anna‐Maria Koivusalo, Johanna Wennervirta, Tapani Salmi, Helena Isoniemi, Ulf‐Håkan Stenman, Hanna Viertiö‐Oja, Petteri Lapinlampi, Leena Lindgren, Ulla‐Stina Salminen, Anne Vakkuri Tags: Original Article Source Type: research

Characterization of pFOX-7a, a conjugative IncL/M plasmid encoding the FOX-7 AmpC-type {beta}-lactamase, involved in a large outbreak in a neonatal intensive care unit
Conclusions pFOX-7a is the first completely characterized plasmid encoding a FOX-type β-lactamase. The blaFOX-7 gene was associated with a putative transposable element of original structure, which was likely involved in its mobilization from the Aeromonas metagenome. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - September 15, 2014 Category: Microbiology Authors: Di Pilato, V., Arena, F., Giani, T., Conte, V., Cresti, S., Rossolini, G. M. Tags: Original research Source Type: research

Assessing the impact of bibliographical support on the quality of medical care in patients admitted to an internal medicine service: a prospective clinical, open, randomised two-arm parallel study
To assess and quantify the impact of the literature in diagnostic decisions and treatment of patients admitted to an internal medicine service using the methodology of evidence-based medicine. From November 2012 to February 2013, patients who were hospitalised in the internal medicine service of Regional Hospital of Lugano (Switzerland) and generated questions on medical care were randomly assigned to two groups: an ‘intervention group’ (supported by the literature research) and a ‘control group’ (not supported by the literature research). The information obtained from the literature was submitted b...
Source: Evidence-Based Medicine - September 15, 2014 Category: Internal Medicine Authors: Pastori, M. M., Sarti, M., Pons, M., Barazzoni, F. Tags: EBM Quality improvement, Medical management, Editor's choice Original EBM research Source Type: research

Parents' views on care of their very premature babies in neonatal intensive care units: a qualitative study
Providing information, support and increased involvement contributes positively to parents satisfaction with their baby's neonatal intensive care unit stay and treatment (Source: BMC Pediatrics - Latest articles)
Source: BMC Pediatrics - Latest articles - September 13, 2014 Category: Pediatrics Authors: Gillian RussellAlexandra SawyerHeike RabeJane BlissGillian GyteLelia DuleySusan Ayers Source Type: research

Covariates of intravenous paracetamol pharmacokinetics in adults
Conclusions: Size and age are important covariates for paracetamol pharmacokinetics explaining approximately 40% of clearance and V2 variability. Dose individualization in adult subpopulations would achieve little benefit in the scenarios explored. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - September 13, 2014 Category: Anesthesiology Authors: Karel AllegaertKlaus OlkkolaKatie OwensMarc Van de VeldeMonique de MaatBrian Anderson Source Type: research

Techniques to ascertain correct endotracheal tube placement in neonates.
CONCLUSIONS: There is insufficient evidence to determine the most effective technique for the assessment of correct ETT placement either in the delivery room or the neonatal intensive care unit. Randomised clinical trials comparing either of these techniques with chest radiography are warranted. PMID: 25217732 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - September 13, 2014 Category: Journals (General) Authors: Schmölzer GM, Roehr CC Tags: Cochrane Database Syst Rev Source Type: research

St. David's investing $16M in pediatric center at North Austin facility
St. David’s HealthCare will launch a new pediatric program at St. David’s North Austin Medical Center that will provide emergency, inpatient and intensive care services for children. The center, which represents a $16 million investment for the health care group, is scheduled to open in December. The program will feature a 10-bed emergency department, eight beds in its surgical inpatient unit and a six-bed pediatric intensive care unit. Staff will include pediatric physicians, nurses and assorted… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - September 12, 2014 Category: American Health Authors: Chad Swiatecki Source Type: research

Positive end-expiratory airway pressure does not aggravate ventilator-induced diaphragmatic dysfunction in rabbits
IntroductionImmobilization of hindlimb muscles in a shortened position results in an accelerated rate of inactivity-induced muscle atrophy and contractile dysfunction. Similarly, prolonged controlled mechanical ventilation (CMV) results in diaphragm inactivity and induces diaphragm muscle atrophy and contractile dysfunction. Further, the application of positive end-expiratory airway pressure (PEEP) during mechanical ventilation would result in shortened diaphragm muscle fibers throughout the respiratory cycle. Therefore, we tested the hypothesis that compared to CMV without PEEP; the combination of PEEP and CMV would accel...
Source: Critical Care - September 12, 2014 Category: Intensive Care Authors: Catherine SassoonErcheng ZhuLiwei FangGary SieckScott Powers Source Type: research

Sodium bicarbonate in the prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis
IntroductionSodium bicarbonate (SBIC) was reported to be a promising approach to prevent cardiac surgery-associated acute kidney injury (CSA-AKI). However, the results remain controversial. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of SBIC on the prevention of CSA-AKI in adult patients undergoing cardiac surgery. Methods: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of SBIC versus placebo on the prevention of CSA-AKI in adult patients undergoing cardiac surgery were in...
Source: Critical Care - September 12, 2014 Category: Intensive Care Authors: Hong-Tao TieMing-Zhu LuoMing-Jing LuoMin ZhangQing-Chen WuJing-Yuan Wan Source Type: research

Heart-lung interactions during neurally adjusted ventilatory assist
IntroductionAssist in unison to the patient?s inspiratory neural effort and feedback- controlled limitation of lung distension with neurally adjusted ventilatory assist (NAVA) may reduce the negative effects of mechanical ventilation on right ventricular function. Methods: Heart-lung interaction was evaluated in 10 intubated patients with impaired cardiac function using esophageal balloons, pulmonary artery catheters and echocardiography. Adequate NAVA level identified by a titration procedure to breathing pattern (NAVAal), 50% NAVAal, and 200% NAVAal and adequate pressure support (PSVal, defined clinically), 50% PSVal, an...
Source: Critical Care - September 12, 2014 Category: Intensive Care Authors: David BergerStefan BloechlingerJukka TakalaChrister SinderbyLukas Brander Source Type: research

In-hospital mortality following treatment with red blood cell transfusion or inotropic therapy during early goal-directed therapy for septic shock: a retrospective propensity-adjusted analysis
IntroductionWe sought to investigate whether treatment of subnormal ( (Source: Critical Care)
Source: Critical Care - September 12, 2014 Category: Intensive Care Authors: Dustin MarkJohn MorehouseYun-Yi HungMamata KeneAndrew ElmsVincent LiuDustin BallardDavid Vinson Source Type: research

Hand-Hygiene Compliance Does Not Predict Rates of Resistant Infections in Critically Ill Surgical Patients.
Conclusions: The 2011 outbreak of MDRA at our institution occurred despite high rates of HHC. Notwithstanding stable rates of HHC, the rates of infection with MRSA, VRE and C. difficile decreased in the general surgical ICU after the outbreak. This suggests that infection control tactics other than HHC play a crucial role in preventing the transmission of nosocomial pathogens, especially when rates of HHC have been maximized. PMID: 25215463 [PubMed - as supplied by publisher] (Source: Hand Surgery)
Source: Hand Surgery - September 12, 2014 Category: Surgery Authors: Jayaraman SP, Klompas M, Bascom M, Liu X, Piszcz R, Rogers SO, Askari R Tags: Surg Infect (Larchmt) Source Type: research

Severe respiratory illness associated with enterovirus d68 - missouri and illinois, 2014.
Abstract On August 19, 2014, CDC was notified by Children's Mercy Hospital in Kansas City, Missouri, of an increase (relative to the same period in previous years) in patients examined and hospitalized with severe respiratory illness, including some admitted to the pediatric intensive care unit. An increase also was noted in detections of rhinovirus/enterovirus by a multiplex polymerase chain reaction assay in nasopharyngeal specimens obtained during August 5-19. On August 23, CDC was notified by the University of Chicago Medicine Comer Children's Hospital in Illinois of an increase in patients similar to those see...
Source: MMWR Morb Mortal Wkl... - September 12, 2014 Category: Epidemiology Authors: Midgley CM, Jackson MA, Selvarangan R, Turabelidze G, Obringer E, Johnson D, Giles BL, Patel A, Echols F, Oberste MS, Nix WA, Watson JT, Gerber SI Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Am J Respir Crit Care Med; +29 new citations
29 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Respir Crit Care Med These pubmed results were generated on 2014/09/11PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - September 11, 2014 Category: Intensive Care Tags: Report Source Type: research

Scoring systems for 6‐month mortality in critically ill cirrhotic patients: a prospective analysis of chronic liver failure – sequential organ failure assessment score (CLIF‐SOFA)
ConclusionBoth CLIF‐SOFA and APACHE III scores are excellent prognosis evaluation tools for critically ill cirrhotic patients. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 11, 2014 Category: Drugs & Pharmacology Authors: H.‐C. Pan, C.‐C. Jenq, M.‐H. Tsai, P.‐C. Fan, C.‐H. Chang, M.‐Y. Chang, Y.‐C. Tian, C.‐C. Hung, J.‐T. Fang, C.‐W. Yang, Y.‐C. Chen Tags: Original Article Source Type: research

Can non‐invasive positive pressure ventilation prevent endotracheal intubation in acute lung injury/acute respiratory distress syndrome? A meta‐analysis
In conclusion, the early use of NIPPV can decrease the endotracheal intubation rate in patients with ALI/ARDS, but does not change the mortality of these patients. (Source: Respirology)
Source: Respirology - September 11, 2014 Category: Respiratory Medicine Authors: Jian Luo, Mao‐yun Wang, Hui Zhu, Bin‐miao Liang, Dan Liu, Xia‐ying Peng, Rong‐chun Wang, Chun‐tao Li, Chen‐yun He, Zong‐an Liang Tags: Review Source Type: research