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Intensive Care

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(Source: Anaesthesia and intensive care medicine)
Source: Anaesthesia and intensive care medicine - July 22, 2014 Category: Anesthesiology Source Type: research

Editorial Board
(Source: Anaesthesia and intensive care medicine)
Source: Anaesthesia and intensive care medicine - July 22, 2014 Category: Anesthesiology Source Type: research

Molecular characterisation and control of
Conclusions: The common utilization of the blood gas device among ICU was the reason for the contamination. AB strains can remain stable for a long period of time, although due to the disinfection procedures applied in hospitals, there is a small chance that the same clone might reappear and cause another epidemic. For that reason, the resistance profiles of the strains must be continuously followed with amplification-based methods, and these methods should be used to support the PFGE method in the short term. (Source: Annals of Clinical Microbiology and Antimicrobials)
Source: Annals of Clinical Microbiology and Antimicrobials - July 22, 2014 Category: Microbiology Authors: Ay¿e ErtürkAy¿egül ÇiçekAziz Gümü¿Erkan CüreAhmet ¿enAysel KurtAlper KaragözNebahat Aydo¿anCemal Sandall¿R¿za Durmaz Source Type: research

The impact of performance status and comorbidities on the short-term prognosis of very elderly patients admitted to the ICU
Conclusions: Performance status and comorbidities are important determinants of short-term outcome in critically ill elderly patients >=80 years old. The addition of simple background information may increase the calibration of the SAPS3 score in this population. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - July 22, 2014 Category: Anesthesiology Authors: Fernando ZampieriFernando Colombari Source Type: research

The characterization of noise levels in a neonatal intensive care unit and the implications for noise management
Conclusions: The statistical analysis revealed a clear correlation between the noise level, the kind of care room, and the time of the day. The results show that the values recommended by international bodies and agencies (AAP, WHO) are surpassed by a large margin, thus making it crucial that certain norms are followed in order to reduce the noise level in the NICU, by means of physical alterations to the layout, and raising awareness of health care personnel and visitors in order to encourage noise prevention in the daily care work and conversation. And finally, has been demonstrated that by applying the t-Student test th...
Source: BioMed Central - July 22, 2014 Category: Journals (General) Authors: Juan Carlos Fortes-GarridoAndres Manuel Velez-PereiraManuel GázquezMontserrat Hidalgo-HidalgoJuan Pedro Bolívar Source Type: research

Modeling the economic impact of linezolid versus vancomycin in confirmed nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus
Conclusion: The model results showed that linezolid has a favorable incremental cost effectiveness ratio compared to vancomycin for MRSA-confirmed nosocomial pneumonia, largely attributable to the higher clinical trial response rate of patients treated with linezolid. The higher drug acquisition cost of linezolid was offset by lower treatment failure-related costs and fewer days of hospitalization. (Source: Critical Care)
Source: Critical Care - July 22, 2014 Category: Intensive Care Authors: Dipen PatelAndrew ShorrJean ChastreMichael NiedermanAndrew SimorJennifer StephensClaudie CharbonneauXin GaoDilip Nathwani Source Type: research

Early sedation and clinical outcomes of mechanically ventilated patients: a prospective multicenter cohort study
Conclusions: Early deep sedation is associated with adverse outcomes and constitutes an independent predictor of hospital mortality in mechanically ventilated patients. (Source: Critical Care)
Source: Critical Care - July 21, 2014 Category: Intensive Care Authors: Lilian TanakaLuciano AzevedoMarcelo ParkGuilherme SchettinoAntonio NassarAlvaro Réa-NetoLuana TannousVicente de Souza-DantasAndré TorellyThiago LisboaClaudio PirasFrederico CarvalhoMarcelo MaiaFabio GianiniFlavia MachadoFelipe Dal-PizzolAlexandre de Car Source Type: research

A multiplex nested PCR for the detection and identification of Candida species in blood samples of critically ill paediatric patients
Conclusions: Our proposed PCR method may represent an effective tool for the detection and identification of Candida species in the context of candidaemia diagnosis in children, showing highly sensitive detection and the ability to identify the major species involved in this infection. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - July 21, 2014 Category: Infectious Diseases Authors: Cleison TairaThelma OkayArtur DelgadoMaria CecconMargarete de AlmeidaGilda Del Negro Source Type: research

An evaluation of enteral nutrition practices and nutritional provision in children during the entire length of stay in critical care
This study evaluated exclusive enteral nutrition (EN) provision practices and explored predictors of energy intake and delay of EN advancement in critically ill children. Methods: Data on intake and EN practices were collected on a daily basis and compared against predefined targets and dietary reference values in a paediatric intensive care unit. Factors associated with intake and advancement of EN were explored. Results: Data were collected from 130 patients and 887 nutritional support days (NSDs). Delay to initiate EN was longer in patients from both the General Surgical and congenital heart defect (CHD) Surgical groups...
Source: BMC Pediatrics - Latest articles - July 21, 2014 Category: Pediatrics Authors: Jackie MaraEmma GentlesHani AlfheeaidKrystalia DiamantidiNeil SpenceleyMark DavidsonDavid YoungKonstantinos Gerasimidis Source Type: research

Am J Respir Crit Care Med; +24 new citations
24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Respir Crit Care Med These pubmed results were generated on 2014/07/20PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - July 20, 2014 Category: Intensive Care Tags: Report Source Type: research

Pediatric Index of Mortality and PIM2 Scores Have Good Calibration in a Large Cohort of Children from a Developing Country.
Conclusion. PIM and PIM2 scores had good calibration in our setup. PMID: 25025075 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - July 19, 2014 Category: Research Authors: Sankar J, Singh A, Sankar MJ, Joghee S, Dewangan S, Dubey N Tags: Biomed Res Int Source Type: research

The management of substance abuse in the critically ill
Substance abuse continues to increase the burden on the health care system. In Diagnostic and Statistical Manual of Mental Health Disorders, 5th edition, text revision (DSM-IV-TR), substance abuse and dependence disorders are now combined into substance use disorders. Substance abuse refers to a maladaptive pattern of substance use leading to clinically significant impairment or distress manifested by at least 1 symptom that interferes with life functioning within a 12-month period. A diagnostic criterion for substance dependence requires at least 3 of the following within a 12-month period: development of tolerance to the...
Source: Disease a Month - July 18, 2014 Category: Infectious Diseases Authors: Gourang Patel Source Type: research

Effect of intraoperative brain protection with propofol on postoperative cognition in patients undergoing temporary clipping during intracranial aneurysm surgery
Conclusions: Pharmacologic neuroprotection with propofol at the time of temporary clipping during surgery for aneurysmal SAH did not offer any advantage as far as preservation of cognition is concerned. (Source: Neurology India)
Source: Neurology India - July 18, 2014 Category: Neurology Authors: Charu MahajanRajendra Singh ChouhanGirija Prasad RathHari Hara DashAshish SuriP Sarat ChandraAman Mahajan Source Type: research

Tight glycaemic control does not improve mortality or morbidity in critically ill children
Commentary on: Macrae D, Grieve R, Allen E, et al.. A randomized trial of hyperglycemic control in pediatric intensive care. N Engl J Med 2014;370:107–18. Context With tight glycaemic control (TGC), blood glucose is maintained at normal fasting levels with intravenous insulin. The efficacy and safety of TGC in critically ill patients is unclear. One study showed that TGC in the surgical intensive care unit reduced mortality and organ failure in critically ill adults1; however, subsequent trials failed to replicate these results. In fact, one multicentre trial showed higher mortality in critically ill adults undergoin...
Source: Evidence-Based Medicine - July 18, 2014 Category: Internal Medicine Authors: Kandil, S. B., Faustino, E. V. S. Tags: Clinical trials (epidemiology), Epidemiologic studies, Diet, Interventional cardiology, Ethics, Diabetes Therapeutics Source Type: research

The emergence of carbapenem resistant Acinetobacter baumannii as the major cause of ventilator associated pneumonia in intensive care patients at an infectious disease hospital in southern Vietnam.
Yen L, Dang Trung Nghia H, Tien Hien T, Thwaites L, Thwaites G, Van Vinh Chau N, Baker S Abstract Ventilator associated pneumonia (VAP) is a serious hospital acquired infection that affects up to 30% of intubated patients on intensive care units (ICUs) worldwide. The aetiology of VAP is highly variable and can differ between countries, national provinces, and even between different wards in same hospital. We aimed to understand and document changes in the causative agents of VAP and their corresponding antimicrobial susceptibility profiles retrospectively over an 11 year-period in a major infectious disease hospita...
Source: Journal of Medical Microbiology - July 18, 2014 Category: Microbiology Authors: Thi Khanh Nhu N, Phu Huong Lan N, Campbell JI, Parry CM, Thompson C, Thanh Tuyen H, Van Minh Hoang N, Thi Thanh Tam P, Minh Le V, Vu Thieu Nga T, Do Hoang Nhu T, Van Minh P, Thi Thu Nga N, Thu Thuy C, Thi Dung L, Thi Thu Yen N, Van Hao N, Thi Loan H, Minh Tags: J Med Microbiol Source Type: research

Risk factors for postoperative CSF leakage after elective craniotomy and the efficacy of fleece-bound tissue sealing against dural suturing alone: a randomized controlled trial.
Conclusions Dural leakage after elective craniotomy/durotomy occurs more frequently in association with diabetes mellitus, elevated preoperative CRP levels, and the intraoperative need of a dural patch. This randomized controlled trial showed no statistically significant reduction of postoperative CSF leakage and surgical site infections upon addition of TachoSil on the dural suture, but there was a significant reduction in the length of stay in the IMC unit. Dural augmentation with TachoSil was safe and not related to adverse events. Clinical trial registration no. NCT00999999 ( http://www.ClinicalTrials.gov ). PMID: ...
Source: Journal of Neurosurgery - July 18, 2014 Category: Neurosurgery Authors: Hutter G, von Felten S, Sailer MH, Schulz M, Mariani L Tags: J Neurosurg Source Type: research

An Evaluation of a Zero-Heat-Flux Cutaneous Thermometer in Cardiac Surgical Patients.
CONCLUSIONS:: Core temperature can be noninvasively measured using the zero-heat-flux method. Bias was small, but precision was slightly worse than our designated 0.5°C limits compared with measurements from a pulmonary artery catheter. PMID: 25045862 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - July 18, 2014 Category: Anesthesiology Authors: Eshraghi Y, Nasr V, Parra-Sanchez I, Van Duren A, Botham M, Santoscoy T, Sessler DI Tags: Anesth Analg Source Type: research

Early intensive care unit‐acquired hypernatremia in severe sepsis patients receiving 0.9% saline fluid resuscitation
ConclusionsEarly acquired hypernatremia is a frequent complication in severe sepsis patients and is associated with the volume of 0.9% saline received during the first 48 h of admission. (Source: Acta Anaesthesiologica Scandinavica)
Source: Acta Anaesthesiologica Scandinavica - July 17, 2014 Category: Anesthesiology Authors: A. VAN DE LOUW, C. SHAFFER, E. SCHAEFER Tags: Original Article Source Type: research

Upper gastrointestinal bleeding in hospital inpatients: the role of antithrombotic drugs
Conclusions Subjects who develop NVGIB as inpatients have higher Rockall scores are mainly older females with cardiovascular disease and using antithrombotic drugs. Secondary care clinicians should be mindful of this at-risk group of patients and consider giving them prophylactic antiulcer therapy. (Source: Postgraduate Medical Journal)
Source: Postgraduate Medical Journal - July 17, 2014 Category: Journals (General) Authors: Taha, A. S., Kelly, C., McCloskey, C., Craigen, T., Angerson, W. J. Tags: GI bleeding, Stomach and duodenum, Drugs: cardiovascular system, Stroke, Drugs: musculoskeletal and joint diseases Original article Source Type: research

Procalcitonin as a prognostic marker for sepsis: a prospective observational study
Background: Procalcitonin is useful for the diagnosis of sepsis but its prognostic value regarding mortality is unclear. This prospective observational study was designed to study the prognostic value of procalcitonin in prediction of 28 day mortality in patients of sepsis. Fifty-four consecutive patients of sepsis, severe sepsis and septic shock defined using the 2001 Consensus Conference SCCM/ESICM/ACCP/ATS/SIS criteria from medical Intensive Care Unit (ICU) of a tertiary care center in New Delhi, India were enrolled from July 2011 to June 2013. Procalcitonin (PCT), C-reactive protein (CRP) measurements were recorded on ...
Source: BMC Research Notes - July 17, 2014 Category: Research Authors: Saransh JainSanjeev SinhaSurendra SharmaJ SamantarayPraveen AggrawalNaval VikramAshutosh BiswasSeema SoodManish GoelMadhuchhanda DasSreenivas VishnubhatlaNawaid Khan Source Type: research

Horse-related trauma in children and adults during a two year period
Conclusion: Horse riding is a sport with well known risks. Our results corresponds to the literature, however we have not observed the same incidence of serious injuries. In contrast we find these to be fairly uncommon. The injuries are mainly minor, with a small risk of long term morbidity. Over time regulations and safety equipment seem to have decreased the number of serious accidents. (Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine)
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - July 17, 2014 Category: Emergency Medicine Authors: Jakob AltgärdeStefan RedéenNiclas HildingPeder Drott Source Type: research

Procalcitonin as a prognostic marker for sepsis: a prospective observational study
Background: Procalcitonin is useful for the diagnosis of sepsis but its prognostic value regarding mortality is unclear. This prospective observational study was designed to study the prognostic value of procalcitonin in prediction of 28 day mortality in patients of sepsis. Fifty-four consecutive patients of sepsis, severe sepsis and septic shock defined using the 2001 Consensus Conference SCCM/ESICM/ACCP/ATS/SIS criteria from medical Intensive Care Unit (ICU) of a tertiary care center in New Delhi, India were enrolled from July 2011 to June 2013. Procalcitonin (PCT), C-reactive protein (CRP) measurements were recorded on...
Source: BMC Research Notes - July 17, 2014 Category: Research Authors: Saransh JainSanjeev SinhaSurendra SharmaJ SamantarayPraveen AggrawalNaval VikramAshutosh BiswasSeema SoodManish GoelMadhuchhanda DasSreenivas VishnubhatlaNawaid Khan Source Type: research

Effects of selective digestive decontamination (SDD) on the gut resistome
Conclusions ICU hospitalization and the simultaneous application of SDD has large, but highly individualized, effects on the gut resistome of ICU patients. Selection for transferable antibiotic resistance genes in anaerobic commensal bacteria could impact the risk of transfer of antibiotic resistance genes to opportunistic pathogens. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - July 16, 2014 Category: Microbiology Authors: Buelow, E., Gonzalez, T. B., Versluis, D., Oostdijk, E. A. N., Ogilvie, L. A., van Mourik, M. S. M., Oosterink, E., van Passel, M. W. J., Smidt, H., D'Andrea, M. M., de Been, M., Jones, B. V., Willems, R. J. L., Bonten, M. J. M., van Schaik, W. Tags: Original research Source Type: research

The Effect of Interdisciplinary Team Rounds on Urinary Catheter and Central Venous Catheter Days and Rates of Infection
Interdisciplinary team (IDT) rounds were initiated in the intensive care unit (ICU) in June 2010. All catheters were identified by location, duration, and indication. Catheters with no indication were removed. Data were collected retrospectively on catheter days and associated infections in a 20-month period before and after intervention with an aggregate of 19 207 ICU days before and 23 576 ICU days after institution of rounds. Results showed a statistically significant decrease in the number of indwelling urinary catheter (IUC) days (5304 vs 4541 days, P = .05) and catheter-associated urinary tract infection rates (4.71 ...
Source: American Journal of Medical Quality - July 16, 2014 Category: Health Management Authors: Arora, N., Patel, K., Engell, C. A., LaRosa, J. A. Tags: Articles Source Type: research

Albumin administration in the acutely ill: what is new and where next?
Albumin solutions have been used worldwide for the treatment of critically ill patients since they became commercially available in the 1940s. However, their use has become the subject of criticism and debate in more recent years. Importantly, all fluid solutions have potential benefits and drawbacks. Large multicenter randomized studies have provided valuable data regarding the safety of albumin solutions, and have begun to clarify which groups of patients are most likely to benefit from their use. However, many questions remain related to where exactly albumin fits within our fluid choices. Here, we briefly summarize som...
Source: Critical Care - July 16, 2014 Category: Intensive Care Authors: Jean-Louis VincentJames RussellMatthias JacobGreg MartinBertrand GuidetJan WernermanRicard RocaStuart McCluskeyLuciano Gattinoni Source Type: research

A new device for continuous assessment of gut perfusion: proof of concept on a porcine model of septic shock
Conclusions: PAC and PDC decreased at the onset of shock and were correlated with GM and lactate. These results confirm that PPG signal reliably reflects the early perfusion alteration of the gut. Further studies should assess the clinical use of this device. (Source: Critical Care)
Source: Critical Care - July 16, 2014 Category: Intensive Care Authors: Matthias Jacquet-LagrèzeJeanne-Marie Bonnet-GarinBernard AllaouchicheOlivia VassalDamien RestagnoChristian PaquetJean-Yves AyoubJérôme EtienneFrançois VandeneschOlivier DaulwaderStéphane Junot Source Type: research

Autism spectrum disorder in a term birth neonatal intensive care unit population
(Source: Pediatric Neurology)
Source: Pediatric Neurology - July 16, 2014 Category: Neurology Authors: Alexander Winkler-Schwartz, Jarred Garfinkle, Michael I. Shevell Source Type: research

Fatal Outbreak of Polyclonal Candidemia in a Neonatal Intensive Care Unit
Victor Costa Morais de Oliveira, MD; Valeria Saraceni, MD, PhD; Izabella Picinin Safe, MD; Alessandra Galvão Martins, MD; Tatyana Costa Amorim Ramos; Joao Vicente Braga de Souza, PhD; Marcelo Cordeiro-Santos, MD, PhD Infection Control and Hospital Epidemiology, Volume 35, Issue 8, Page 1077-1079, August 2014. (Source: Infect Control Hosp Epidemiol Latest Issue)
Source: Infect Control Hosp Epidemiol Latest Issue - July 15, 2014 Category: Epidemiology Tags: article Letters to the Editor Source Type: research

Research networks and their contribution to the quality of critical care
(Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - July 15, 2014 Category: Intensive Care Source Type: research

Research networks and clinical trials in critical care in Brazil: current status and future perspectives
(Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - July 15, 2014 Category: Intensive Care Source Type: research

Sedation and memories in critical care
(Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - July 15, 2014 Category: Intensive Care Source Type: research

The use of hypothermia and outcome post cardiopulmonary resuscitation in 2014
(Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - July 15, 2014 Category: Intensive Care Source Type: research

Use of antipsychotics for the treatment of intensive care unit delirium
(Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - July 15, 2014 Category: Intensive Care Source Type: research

Brazilian recommendations of mechanical ventilation 2013. Part I
O suporte ventilatório artificial invasivo e não invasivo ao paciente crítico tem evoluído e inúmeras evidências têm surgido, podendo ter impacto na melhora da sobrevida e da qualidade do atendimento oferecido nas unidades de terapia intensiva no Brasil. Isto posto, a Associação de Medicina Intensiva Brasileira (AMIB) e a Sociedade Brasileira de Pneumonia e Tisiologia (SBPT) - representadas pelo seus Comitê de Ventilação Mecânica e Comissão de Terapia Intensiva, respectivamente, decidiram revisar a literatura e preparar recomendações sobre ventilação mecânica objetivando oferecer aos associados um docume...
Source: Revista Brasileira de Terapia Intensiva - July 15, 2014 Category: Intensive Care Source Type: research

Sedation and memories of patients subjected to mechanical ventilation in an intensive care unit
Conclusion: The probability of the occurrence of illusory memories was greater among the participants who were subjected to deep sedation. Sedation seems to be an additional factor that contributed to the occurrence of illusory memories in severely ill individuals subjected to mechanical ventilation. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - July 15, 2014 Category: Intensive Care Source Type: research

Inflammatory and perfusion markers as risk factors and predictors of critically ill patient readmission
Conclusion: Inflammatory and perfusion parameters were not associated with patient readmission. Increased age and contact isolation because of multidrug-resistant organisms were identified as predictors of readmission to the intensive care unit. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - July 15, 2014 Category: Intensive Care Source Type: research

Ventilatory weaning practices in intensive care units in the city of Cali
Conclusion: Existe una gran variabilidad sobre los métodos y la medición de los parámetros de destete ventilatorio. El método más utilizado fue presión positiva continua en la vía aérea más presión de soporte y los parámetros de destete más usados fueron la medición del volumen corriente y la frecuencia respiratoria. Objective: Early weaning from mechanical ventilation is one of the primary goals in managing critically ill patients. There are various techniques and measurement parameters for such weaning. The objective of this study was to describe the practices of ventilatory weaning in adult intensive care u...
Source: Revista Brasileira de Terapia Intensiva - July 15, 2014 Category: Intensive Care Source Type: research

Fractional excretion of potassium in the course of acute kidney injury in critically ill patients: potential monitoring tool?
Conclusion: Sequential fractional excretion of potassium assessment appears to be useful in critically ill patients at risk for acute kidney injury. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - July 15, 2014 Category: Intensive Care Source Type: research

Sepsis in intensive care unit patients with traumatic brain injury: factors associated with higher mortality
Conclusion: Septic shock and progressive organ (particularly respiratory) dysfunction increases the mortality of patients with traumatic brain injury and sepsis. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - July 15, 2014 Category: Intensive Care Source Type: research

Adequacy of energy and protein balance of enteral nutrition in intensive care: what are the limiting factors?
Conclusion: Early enteral nutritional therapy and the adequacy for both energy and protein of the nutritional volume infused were in accordance with the established guidelines. Possible inadequacies of energy and protein balance appeared to be associated with an acute inflammatory response, which was characterized by elevated C-reactive protein levels. The main cause of interruption of the enteral nutritional therapy was the time spent in extubation. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - July 15, 2014 Category: Intensive Care Source Type: research