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Silent PE raises risk for early symptomatic PE in DVT patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Patients with silent pulmonary embolism at the time of deep vein thrombosis diagnosis have an increased risk for symptomatic PE during the first 2 weeks of therapy, study findings indicate. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - February 6, 2012 Category: Internal Medicine Source Type: news

Response to letter to the editor by Caturelli and Ghittoniemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Hepatology)
Source: Hepatology - February 6, 2012 Category: Internal Medicine Authors: Korosh KhaliliMorris Sherman Tags: Correspondence Source Type: research

I148M PNPLA3 variant and progressive liver disease: A new paradigm in hepatologyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Hepatology)
Source: Hepatology - February 6, 2012 Category: Internal Medicine Authors: Luca ValentiAnna AlisiValerio Nobili Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Presence of precore and core promoter mutants limits the probability of response to peginterferon in HBeAg‐positive chronic hepatitis Bemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion:Presence of only WT virus at baseline is a strong predictor of response (HBeAg loss with HBV DNA <10,000 copies/mL) to PEG‐IFN for HBeAg‐positive CHB. Patients with detectable PC and/or BCP mutants have a lower probability of response and are less optimal candidates for PEG‐IFN therapy. (HEPATOLOGY 2012.) (Source: Hepatology)
Source: Hepatology - February 6, 2012 Category: Internal Medicine Authors: Milan J. SonneveldVincent RijckborstStefan ZeuzemE. Jenny HeathcoteKrzysztof SimonHakan SenturkSuzan D. PasBettina E. HansenHarry L.A. Janssen Tags: Viral Hepatitis Source Type: research

Diarrhea predicts a positive response to sorafenib in patients with advanced hepatocellular carcinomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Hepatology)
Source: Hepatology - February 6, 2012 Category: Internal Medicine Authors: Dominik BettingerMichael SchultheißEva KnüppelRobert ThimmeHubert E. BlumHans Christian Spangenberg Tags: Correspondence Source Type: research

Assessment by fibroscan of fibrosis in NAFLD: XL vs. M probe?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Hepatology)
Source: Hepatology - February 6, 2012 Category: Internal Medicine Authors: Salvatore PettaAntonio Craxì Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Drug‐related adverse events may predict efficacy in sorafenib therapy for hepatocellular carcinomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Hepatology)
Source: Hepatology - February 6, 2012 Category: Internal Medicine Authors: Yan ZhaoMan YangXingshun QiGuohong HanDaiming Fan Tags: Correspondence Source Type: research

MRC sum‐score in the ICU: Good reliability does not necessarily reflect ‘true reliability’email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Muscle and Nerve)
Source: Muscle and Nerve - February 6, 2012 Category: Internal Medicine Authors: Els Karla VanhoutteCatharina Gerritdina FaberIngemar Sergio José Merkies Tags: Letter to the Editor Source Type: research

Effect of stimulation intensity on assessment of voluntary activationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Discussion:Submaximal muscle stimulation can be used to estimate VA in the knee extensors. It is less painful, and overestimation of VA may be less compared to maximal nerve stimulation. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve)
Source: Muscle and Nerve - February 6, 2012 Category: Internal Medicine Authors: Daniël M. van LeeuwenCornelis J. de RuiterArnold de Haan Tags: Research Article Source Type: research

Zoster‐associated mononeuropathies (ZAMs): A retrospective seriesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions:While ZAM is an uncommon occurrence following cutaneous HZ, it is associated with significant weakness, high rates of post‐herpetic neuralgia, and prolonged morbidity. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve)
Source: Muscle and Nerve - February 6, 2012 Category: Internal Medicine Authors: Haatem RedaJames C. WatsonLyell K. Jones Tags: Research Article Source Type: research

A new model of experimental fibrosis in hindlimb skeletal muscle of adult mdx mouse mimicking muscular dystrophyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Discussion.This induced fibrotic dystrophic model may be useful to study mechanisms of fibrosis in dystrophinopathies and to evaluate antifibrotic treatments. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve)
Source: Muscle and Nerve - February 6, 2012 Category: Internal Medicine Authors: Isabelle DesguerreLudovic ArnoldAlban VignaudSylvain CuvellierHouda Yacoub‐YoussefRomain K GherardiJamel ChellyFabrice ChretienRémi MounierArnaud FerryBénédicte Chazaud Tags: Research Article Source Type: research

New motor outcome function measures in evaluation of late‐onset Pompe disease before and after ERTemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
DISCUSSION.GSGC is a group of functional tests that require only few minutes to perform, therefore, this score might be a good indicator to be used in future studies. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve)
Source: Muscle and Nerve - February 6, 2012 Category: Internal Medicine Authors: Corrado AngeliniClaudio SempliciniSabrina RavagliaMaurizio MoggioGiacomo P. ComiOlimpia MusumeciElena PegoraroPaola ToninMassimiliano FilostoSerenella ServideiLucia MorandiGrazia CrescimannoGiovanni MarrosuGabriele SicilianoTiziana MonginiAntonio Toscano Tags: Research Article Source Type: research

Chronic inflammatory demyelinating polyneuropathy associated with alopecia totalis and Sjögren's syndromeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Muscle and Nerve)
Source: Muscle and Nerve - February 6, 2012 Category: Internal Medicine Authors: Lara SanvitoSiew L. WongYusuf A. Rajabally Tags: Letter to the Editor Source Type: research

Goya and a possible first visual representation of Charcot‐Marie‐Tooth diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Muscle and Nerve)
Source: Muscle and Nerve - February 6, 2012 Category: Internal Medicine Authors: José María Pérez‐TrullénAlvaro Giménez‐MuñozJose Carlos RocheIsabel CampelloMaría José García GomaraSara Sánchez Valiente Tags: Letter to the Editor Source Type: research

The French Paradox and Other Ecological FallaciesThe French Paradox and Other Ecological Fallaciesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A historical perspective of ecological fallacies in medicine, which arise when disease differences identified between countries are assumed to be caused by factors that are found to also differ. International Journal of Epidemiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 5, 2012 Category: Consumer Health News Tags: Internal Medicine Journal Article Source Type: news

National Briefing | Health: Officials Recommend the HPV Vaccine for All Boysemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Federal health officials recommended on Thursday that all boys be routinely vaccinated against infection with human papillomavirus, or HPV. (Source: NYT)
Source: NYT - February 3, 2012 Category: American Health Authors: By ANAHAD O’CONNOR Tags: Human Papilloma Virus (HPV) Vaccination and Immunization Sexually Transmitted Diseases Centers for Disease Control and Prevention Annals of Internal Medicine Children and Childhood Men and Boys Source Type: news

Single dose NTBC-treatment of hereditary tyrosinemia type Iemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  NTBC (2-(2-nitro-4-trifluoromethylbenzoyl)-1,3cyclohexanedione) is the mainstay of treatment in tyrosinemia type 1 (HT 1). The current recommendation is to divide the total daily dose of NTBC into two doses. We monitored the plasma NTBC concentrations in a series of seven patients who were changed from multiple divided doses to a single daily dose of NTBC. Two additional patients were started on a single daily dose of NTBC after the diagnosis of HT 1 was established. In three patients, NTBC kinetics were performed over 6 and 24 hours, respectively. The use of multiple divided doses or a single daily...
Source: Journal of Inherited Metabolic Disease - February 3, 2012 Category: Internal Medicine Tags: Journal of Inherited Metabolic Disease Source Type: research

Protein farnesylation and diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Prenylation consists of the addition of an isoprenoid group to a cysteine residue located near the carboxyl terminal of a protein. This enzymatic posttranslational modification is important for the maturation and processing of proteins. Both processes are necessary to mediate protein-protein and membrane-protein associations, in addition to regulating the localisation and function of proteins. The severe phenotype of animals deficient in enzymes involved in both prenylation and maturation highlights the significance of these processes. Moreover, alterations in the genes coding for isoprenylated prot...
Source: Journal of Inherited Metabolic Disease - February 3, 2012 Category: Internal Medicine Tags: Journal of Inherited Metabolic Disease Source Type: research

Over 10% of lower extremity DVT cases isolated to calfemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
More than one in 10 cases of lower extremity deep vein thrombosis are isolated to the distal calf, results of a community-based study show. (Source: MedWire News - Thrombosis)
Source: MedWire News - Thrombosis - February 3, 2012 Category: Internal Medicine Source Type: news

Two Studies Find that Patients Want Access to their Health Records, Including Clinical Pathology Test Dataemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Patients are ready to ready access to their medical records; but physicians are wary Data from two studies here in the United States affirms that patients want access to their health records. Consequently, health systems are increasingly making it easier for patients to get access to prescription lists, medical laboratory test results and now even [...] (Source: Dark Daily)
Source: Dark Daily - February 3, 2012 Category: Laboratory Medicine Authors: jude Tags: Laboratory News Laboratory Pathology Annals of Internal Medicine Beth Israel Deaconess Medical Center clinical laboratory Donna Zulman Geisinger Health System Harborview Medical Center harvard medical school kaiser permanente Kenneth S Source Type: news

From the Editors’ Desk: Improving Performance Through Coaching, Incentives, Feedback, and Practiceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticlePages 1-2DOI 10.1007/s11606-012-1999-3Authors Richard L. Kravitz, Division of General Medicine, University of California Davis, Sacramento, CA, USA Journal Journal of General Internal MedicineOnline ISSN 1525-1497Print ISSN 0884-8734 (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - February 3, 2012 Category: Internal Medicine Tags: Journal of General Internal Medicine Source Type: research

Enhancing Care for Hospitalized Older Adults with Cognitive Impairment: A Randomized Controlled Trialemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  A simple screening program for CI followed by a CDSS did not change physician prescribing behaviors or improve the process of care for hospitalized older adults with CI. Content Type Journal ArticleCategory Original ResearchPages 1-7DOI 10.1007/s11606-012-1994-8Authors Malaz A. Boustani, Indiana University Center for Aging Research, Indianapolis, IN, USANoll L. Campbell, Indiana University Center for Aging Research, Indianapolis, IN, USABabar A. Khan, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USAGreg Abernathy, Regenstrief Institute, Inc, 410 West 10t...
Source: Journal of General Internal Medicine - February 3, 2012 Category: Internal Medicine Tags: Journal of General Internal Medicine Source Type: research

Inappropriate Medication in Home Health Careemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory LettersPages 1-1DOI 10.1007/s11606-012-1997-5Authors Yuhua Bao, Department of Public Health, Weill Cornell Medical College, 402 E. 67th St., New York, NY 10065, USAHuibo Shao, Department of Public Health, Weill Cornell Medical College, 402 E. 67th St., New York, NY 10065, USATara F. Bishop, Departments of Public Health and Medicine, Weill Cornell Medical College, New York, NY, USABruce R. Schackman, Department of Public Health, Weill Cornell Medical College, 402 E. 67th St., New York, NY 10065, USAMartha L. Bruce, Department of Psychiatry, Weill Cornell Medical College, White Plains...
Source: Journal of General Internal Medicine - February 3, 2012 Category: Internal Medicine Tags: Journal of General Internal Medicine Source Type: research

Communication and Behavior Change Challenges to Limiting the Development of Antibiotic Resistanceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory EditorialsPages 1-2DOI 10.1007/s11606-012-2000-1Authors Timothy Edgar, Department of Communication Sciences and Disorders, Emerson College, 120 Boylston Street, Boston, MA 02116, USA Journal Journal of General Internal MedicineOnline ISSN 1525-1497Print ISSN 0884-8734 (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - February 3, 2012 Category: Internal Medicine Tags: Journal of General Internal Medicine Source Type: research

Improving test properties for neonatal cystic fibrosis screening in the Netherlands before the nationwide start by May 1st 2011email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  When new technical possibilities arise in health care, often attunement is needed between different actors from the perspectives of research, health care providers, patients, ethics and policy. For cystic fibrosis (CF) such a process of attunement in the Netherlands started in a committee of the Health Council on neonatal screening in 2005. In the balancing of pros and cons according to Wilson and Jungner criteria, the advantages for the CF patient were considered clear, even though CF remains a severe health problem with treatment. Nevertheless, screening was not started then, mainly since the spec...
Source: Journal of Inherited Metabolic Disease - February 3, 2012 Category: Internal Medicine Tags: Journal of Inherited Metabolic Disease Source Type: research

Inflammation and related biomarkers in cardiovascular diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Biomarkers in Medicine , February 2012, Vol. 6, No. 1, Pages 1-3. (Source: Future Medicine: Biomarkers in Medicine)
Source: Future Medicine: Biomarkers in Medicine - February 2, 2012 Category: Internal Medicine Tags: article Source Type: research

National Briefing | Health: Officials Recommend the HPV Vaccine for All Boysemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Federal health officials recommended on Thursday that all boys be routinely vaccinated against infection with human papillomavirus, or HPV. (Source: NYT Health)
Source: NYT Health - February 2, 2012 Category: Consumer Health News Authors: By ANAHAD O'CONNOR Tags: Human Papilloma Virus (HPV) Vaccination and Immunization Sexually Transmitted Diseases Centers for Disease Control and Prevention Annals of Internal Medicine Children and Childhood Source Type: news

Matrix metalloproteinases in metabolic syndrome.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract Metabolic syndrome is commonly accompanied by an elevated cardiovascular risk with high morbidity and mortality. The alterations of the arterial vasculature begin with endothelial dysfunction and lead to micro- and macrovascular complications. The remodeling of the endothelial basal membrane, that promotes erosion and thrombosis, has a multifactorial pathogenesis that includes leukocyte activation, increased oxidative stress and also an altered matrix metalloproteinases (MMPs) expression. MMPs are endopeptidases which degrade extracellular matrix proteins, such as collagen, gelatins, fibronectin and lamini...
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Hopps E, Caimi G Tags: Eur J Intern Med Source Type: research

On the nature of sarcoidosis.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract More than 140years since its recognition as a clinical entity, sarcoidosis remains enigmatic. Its classification as a disease vs. a syndrome is uncertain. Its etiology remains undefined. The "immune paradox" (delayed type hypersensitivity anergy in a setting of exuberant systemic granulomatous response) resists explanation. Its relationship to the Kveim test is poorly understood. Its prognostic determinants and treatment indications are among the unsolved or disputed problems. Immunological investigations generated the thesis that the characterizing systemic granuloma arise as a fallback reaction to ineffi...
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Reich JM Tags: Eur J Intern Med Source Type: research

Excessive daytime sleepiness and narcolepsy - An approach to investigation and management.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract Excessive daytime sleepiness is a common presentation to physicians both in general practice and hospital settings. In this review, we provide an update on the latest theories on the pathogenesis of the condition, and discuss the approach to investigation of the sleepy patient, with particular reference to narcolepsy. Recommended therapy is reviewed for both narcolepsy and cataplexy, to provide physicians with an important reference on the investigation and management of these troubling conditions. PMID: 22284238 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Morrison I, Riha RL Tags: Eur J Intern Med Source Type: research

The frailty dilemma. Review of the predictive accuracy of major frailty scores.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: As the number of false positive values of most available tests is substantial, these frailty scores are of limited value for both screening and diagnostic purposes in daily practice. As diagnostic instruments they can best be used to exclude frailty. The false-positive rate of currently available tests is too high to allow major decisions on medical care to be made on the basis of a positive test. PMID: 22284239 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Pijpers E, Ferreira I, Stehouwer CD, Nieuwenhuijzen Kruseman AC Tags: Eur J Intern Med Source Type: research

Prevention of delirium in demented hospitalized patients.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
PMID: 22284240 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Andro M, Comps E, Estivin S, Gentric A Tags: Eur J Intern Med Source Type: research

Dipeptidylpeptidase-4 (DPP-4) inhibitors are favourable to glucagon-like peptide-1 (GLP-1) receptor agonists: Yes.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract The pharmacological treatment of type 2 diabetes (T2DM) is becoming increasingly complex, especially since the availability of incretin-based therapies. Compared with other glucose-lowering strategies, these novel drugs offer some advantages such as an absence of weight gain and a negligible risk of hypoglycaemia and, possibly, better cardiovascular and β-cell protection. The physician has now multiple choices to manage his/her patient after secondary failure of metformin, and the question whether it is preferable to add an oral dipeptidylpeptidase-4 (DPP-4) inhibitor (gliptin) or an injectable glucagon-l...
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Scheen AJ Tags: Eur J Intern Med Source Type: research

Dipeptidyl peptidase-4 (DPP-4) inhibitors are favourable to Glucagon-Like Peptide-1 (GLP-1) agonists: No.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract Incretin-based therapies, which include the GLP-1 receptor agonists and DPP-4 inhibitors, use the antidiabetic properties of potentiating the GLP-1 receptor signalling via the regulation of insulin and glucagon secretion, inhibition of gastric emptying and suppression of appetite. Most physicians will start antidiabetic treatment with metformin, but adding a GLP-1 receptor agonist as the second drug seems to be optimal since more patients will reach an HbA1c below 7% than with a DPP-4 inhibitor or another oral antidiabetic agents and with minimal risk of hypoglycaemia. The GLP-1 receptor agonists are also ...
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Madsbad S Tags: Eur J Intern Med Source Type: research

The association of physical activity with novel adipokines in patients with type 2 diabetes.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: Self-controlled physical activity of, even, moderate intensity ameliorates adipokines, such as visfatin, apelin and adiponectin, in patients with T2DM. Prospective interventional studies will confirm our results. The ClinicalTrials.gov identifier is: NCT00306176. PMID: 22284243 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Kadoglou NP, Vrabas IS, Kapelouzou A, Angelopoulou N Tags: Eur J Intern Med Source Type: research

Quality of life in type 2 diabetes mellitus after a very low calorie diet and exercise.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSION: A 16-week VLCD induces considerable weight loss, metabolic amelioration, and major improvements in QoL in obese T2DM patients. The addition of exercise is of paramount importance for the maintenance of better QoL. PMID: 22284244 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Snel M, Sleddering MA, Vd Peijl ID, Romijn JA, Pijl H, Edo Meinders A, Jazet IM Tags: Eur J Intern Med Source Type: research

Erythrocyte mechanical fragility is increased in patients with type 2 diabetes.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: Our data suggest that patients with type 2 diabetes have a significantly higher erythrocyte mechanical fragility than matched nondiabetic subjects, and that fasting plasma glucose is the strongest correlate of increased mechanical fragility of erythrocytes in this patients group. PMID: 22284245 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Lippi G, Mercadanti M, Aloe R, Targher G Tags: Eur J Intern Med Source Type: research

Anemia as a risk factor for low bone mineral density in postmenopausal Turkish women.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSION: We have found that the presence of anemia was as an independent predictor of LBM for spine after adjusting for body mass index and other confounders in postmenopausal Turkish women. PMID: 22284246 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Korkmaz U, Korkmaz N, Yazici S, Erkan M, Baki AE, Yazici M, Ozhan H, Ataoğlu S Tags: Eur J Intern Med Source Type: research

Quick diagnosis units or conventional hospitalisation for the diagnostic evaluation of severe anaemia: A paradigm shift in public health systems?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: For diagnostic purposes, patients with severe anaemia can be managed similarly in a QDU or in-hospital setting, but the QDU model is more cost-saving than traditional hospitalisation. Most QDU patients preferred the QDU model to hospital admission. PMID: 22284247 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Bosch X, Palacios F, Inclán-Iríbar G, Castañeda M, Jordán A, Moreno P, Coca A, López-Soto A Tags: Eur J Intern Med Source Type: research

Comparison of levofloxacin-containing sequential and standard triple therapies for the eradication of Helicobacter pylori.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSION: The levofloxacin-containing sequential therapy is a significantly better strategy than the standard triple treatment for H. pylori eradication. Standard triple treatment is no more effective for H. pylori in our population and levofloxacin-containing sequential regimen might be used as a first-line eradication option. PMID: 22284248 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Polat Z, Kadayifci A, Kantarcioglu M, Ozcan A, Emer O, Uygun A Tags: Eur J Intern Med Source Type: research

Growth differentiation factor-15, a novel biomarker related with disease severity in patients with hypertrophic cardiomyopathy.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: The present results show that higher levels of GDF-15 are associated to conditions of severe disease in HCM. Hence, GDF-15 is suggested as a novel marker related to the severity and could represent a further useful tool in monitoring functional capacity of HCM patients. PMID: 22284249 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Montoro-García S, Hernández-Romero D, Jover E, García-Honrubia A, Vilchez JA, Casas T, Martínez P, Climent V, Caballero L, Valdés M, Marín F Tags: Eur J Intern Med Source Type: research

Association between the polymorphism of estrogen receptor α and coronary artery disease in a Chinese population.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: The ERa PvuII polymorphism is associated with the increased risk of CAD in men of a Chinese population. Further research is needed to investigate the mechanism underlying the association between ERα polymorphism and CAD. PMID: 22284250 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Shen C, Chen J, Fan S, Li Z, Hu Y, Zhong Q Tags: Eur J Intern Med Source Type: research

Effects of renin-angiotensin blockers/inhibitors and statins on mortality and functional impairment in polypathological patients.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: The prescription of statins, alone or in combination with other drugs, may impact the survival and functional decline in polypathological patients. Further prospective blinded randomised assays are needed to confirm these observations. PMID: 22284251 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Galindo-Ocaña J, Bernabeu-Wittel M, Formiga F, Fuertes-Martín A, Barón-Franco B, Murcia-Zaragoza JM, Moreno-Gaviño L, Ollero-Baturone M, Tags: Eur J Intern Med Source Type: research

Routinely adding ultrasound examinations by pocket-sized ultrasound devices improves inpatient diagnostics in a medical department.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSION: By adding a pocket-sized ultrasound examination of <10min to usual care, we corrected the diagnosis in almost 1 of 5 patients admitted to a medical department, resulting in a completely different treatment strategy without delay in many of the patients. Routinely adding a cardiac and abdominal ultrasound screening has the potential to rearrange inpatients workflow and diagnosis. PMID: 22284252 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Mjolstad OC, Dalen H, Graven T, Kleinau JO, Salvesen O, Haugen BO Tags: Eur J Intern Med Source Type: research

An observational study on bloodstream extended-spectrum beta-lactamase infection in critical care unit: Incidence, risk factors and its impact on outcome.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSION: There is a high incidence of ESBL producing organisms causing blood stream infections in critically ill patients. Transfer from other hospitals and previous antibiotic usage are important risk factors for ESBL production. However ESBL production may not be associated with a poorer outcome if appropriate early antibiotic therapy is instituted. PMID: 22284253 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Nasa P, Juneja D, Singh O, Dang R, Singh A Tags: Eur J Intern Med Source Type: research

Serum osmolarity as an outcome predictor in hospital emergency medical admissions.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSION: Admission osmolarity, a simple calculation, is associated with the risk of mortality in acutely ill medical patients; deviations outside the normal range are relevant. A useful clinical predictive algorithm requires the incorporation of additional predictors. PMID: 22284254 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Nicholson T, Bennett K, Silke B Tags: Eur J Intern Med Source Type: research

Prevalence of thoracic vertebral fractures in Spanish patients hospitalized in Internal Medicine Departments. Assessment of the clinical inertia. (PREFRAMI study).email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS: A high prevalence of asymptomatic VF is verified in medical inpatients ≥50years of age. The FRAX index did not turn out to be predictive of the presence of VF in this population. There is an underdiagnosis of osteoporotic VF in the coding at hospital discharge. Action protocols are necessary to avoid clinical inactivity regarding this entity. PMID: 22284255 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Fernández SS, Miralles F, Serrato AR, Alegría JG, Cantero AR, Ordoñez MA, Terán CM, Zorzano EG, Gómez-Huelgas R Tags: Eur J Intern Med Source Type: research

The prevalence of Neurally Mediated Syncope in older patients presenting with unexplained falls.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSION: Falls are unexplained in a significant number of older patients presenting to acute hospitals. The assessment of unexplained fallers for NMS is clinically important as this may be aetiologically related in nearly a quarter of these patients. PMID: 22284256 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Anpalahan M, Gibson S Tags: Eur J Intern Med Source Type: research

Emergency visits and hospital admissions in aged people living close to a gas-fired power plant.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
DISCUSSION: Combustion of natural gas for energy generation produces a rise in air concentration of PM10 and NO(2) close to the plant, with a concentration-dependent increment of daily emergency visits and hospital admissions in elderly people, and with an age-dependent susceptibility. PMID: 22284257 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Di Ciaula A Tags: Eur J Intern Med Source Type: research

Human papillomavirus detected in esophageal squamous cell carcinoma in Iran.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSION: In conclusion, the present study showed that a small proportion of ESCC specimens from Iran harbor HPV16, 18 genome using a highly sensitive method. As different rates have been reported from Iran, a more widespread study with more precise definition of geographical differences could delineate the potential involvement of HPV in the development of ESCC in Iranian population. PMID: 22284258 [PubMed - in process] (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Abdirad A, Eram N, Behzadi AH, Koriyama C, Parvaneh N, Akiba S, Kato T, Kahn N, Ghofrani M, Sadigh N Tags: Eur J Intern Med Source Type: research