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This page shows you the most recent publications within this specialty of the MedWorm directory.

Lipocalin‐2 negatively modulates the EMT in hepatocellular carcinoma through the EGF (TGF‐beta1)/Lcn2/Twist1 pathway
Conclusions: Together, our findings indicate that Lcn2 can negatively modulate the EMT in HCC cells through an EGF (or TGF‐β1)/Lcn2/Twist1 pathway. Thus, Lcn2 may be a candidate metastasis suppressor and a potential therapeutic target in HCC. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Yun‐Peng Wang, Goung‐Ran Yu, Mi‐Jin Lee, Sang‐Yeop Lee, In‐Sun Chu, Sun‐Hee Leem, Dae‐Ghon Kim Tags: Hepatobiliary Malignancies Source Type: research

Role of the inflammasome in inflammatory responses and subsequent injury after hepatic ischemia‐reperfusion injury
(Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Jerzy W. Kupiec‐Weglinski, Naoko Kamo Tags: Correspondence Source Type: research

Chronic hepatitis B infection in adolescents vaccinated at birth: An alarm bell in favor of the need for a booster?
(Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Luisa Romanò, Rita Carsetti, Alberto E Tozzi, Alfonso Mele, Alessandro R Zanetti Tags: Correspondence Source Type: research

Vitamin D nuclear receptor deficiency promotes cholestatic liver injury by disruption of biliary epithelial cell junctions in mice
Conclusion: Biliary‐type liver injury is exacerbated in Vdr‐/‐mice by limited adaptive response and increased bile duct rupture. These results indicate that loss of VDR restricts the adaptation to cholestasis and diminishes bile duct integrity in the setting of biliary‐type liver injury. (HEPATOLOGY2013.) (Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Delphine Firrincieli, Silvia Zúñiga, Colette Rey, Dominique Wendum, Elisabeth Lasnier, Dominique Rainteau, Thomas Braescu, Thomas Falguières, Mathieu Boissan, Axelle Cadoret, Chantal Housset, Nicolas Chignard Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research

Ketamine abuse, biliary tract disease and secondary sclerosing cholangitis
(Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Aaron Turkish, Jean J. Luo, Jay H. Lefkowitch Tags: Clinical Observations in Hepatology Source Type: research

When and for whom should booster hepatitis B vaccination be recommended?
(Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Tzu‐Wei Wu, Hans Hsienhong Lin, Li‐Yu Wang Tags: Correspondence Source Type: research

Regional and global summary estimates of anti‐HCV prevalence in detainee populations: Seeing the forest and the trees?
(Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Amy Jo Harzke Tags: Hepatobiliary Malignancies Source Type: research

Does mild resistance training resemble a similar stimulus than aerobic training?
(Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Dominik Pesta, Martin Burtscher Tags: Correspondence Source Type: research

Cognitive improvement after HCV eradication: Extending the benefits
(Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Jasmohan S Bajaj, Daniel M Forton Tags: Viral Hepatitis Source Type: research

Does mild resistance training resemble a similar stimulus than aerobic training?
(Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Elisabetta Bacchi, Carlo Negri, Giovanni Targher, Massimo Lanza, Federico Schena, Paolo Moghetti Tags: Correspondence Source Type: research

Platelet‐derived growth factor‐D: A new player in the complex crosstalk between cholangiocarcinoma cells and cancer‐associated fibroblasts
(Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Carmen Berasain, Matias A Ávila Tags: Hepatobiliary Malignancies Source Type: research

Donor risk index for african american liver transplant recipients with hepatitis C virus
Abstract African‐American (AA) liver transplant (LT) recipients with hepatitis C virus (HCV) have higher rates of graft loss than other racial/ethnic groups. The Donor Risk Index (DRI) predicts graft loss but is neither race nor disease‐specific and may not be optimal for assessing donor risk for AA HCV‐positive LT recipients. We developed a DRI for AA with HCV with the goal of enhancing graft loss predictions. All U.S. HCV‐positive adult AA first deceased donor LTs surviving ≥30 days from 3/2002 to 12/2009 were included. A total of 1766 AA LT recipients were followed for median 2.8 (IQR 1.3‐4.9) years. Indepen...
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Nathan J Shores, Jennifer L. Dodge, Sandy Feng, Norah A. Terrault Tags: Viral Hepatitis Source Type: research

Intrapulmonary shunt confirmed by intracardic echocardiography in the diagnosis of hepatopulmonary syndrome
We describe the case of a 59‐year‐old man with cirrhosis and hypoxemia whose clinical picture was suspicious for hepatopulmonary syndrome. A transthoracic echocardiogram saline contrast bubble study was unable to decipher between intracardiac and intrapulmonary shunting. Transesophageal echocardiogram could not be done due to esophageal varices. The presence of intrapulmonary shunting was proven by right heart catheterization with direct injection of agitated saline into the pulmonary artery. Bubbles were detected entering the left atrium by intracardiac echocardiogram, thus confirming the diagnosis of hepatopulmonary ...
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Joseph E. Khabbaza, Richard A. Krasuski, Adriano R. Tonelli Tags: Clinical Observations in Hepatology Source Type: research

Hepatic gene therapy using lentiviral vectors: Has safety been established?
(Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: David Dismuke, R. Jude Samulski Tags: Viral Hepatitis Source Type: research

Longitudinal comparison between MRI, MRS and histology‐determined steatosis in NAFLD patients at two‐time points in a randomized trial
Conclusion:In this longitudinal study, MRI‐estimated PDFF correlates well with MRS‐measured‐PDFF and is more sensitive than histology‐determined steatosis grade in quantifying increase or decrease in liver fat content. Therefore, it may be used to quantify changes in liver fat in future clinical trials. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Mazen Noureddin, Jessica Lam, Michael R. Peterson, Michael Middleton, Gavin Hamilton, Thuy‐Anh Le, Ricki Bettencourt, Chris Changchien, David A. Brenner, Claude Sirlin, Rohit Loomba Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Hepatocellular cancer risk in diabetes: Not all diabetics are the same
(Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Siddharth Singh, Preet Paul Singh Tags: Correspondence Source Type: research

Relevance of NK‐mesenchymal stem cell interactions in AN in vivo model of fulminant liver failure
(Source: Hepatology)
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Stefania Bruno, Ciro Tetta, Giovanni Camussi Tags: Correspondence Source Type: research

Disease-modifying factors in hereditary angioedema: an RNA expression-based screening
Conclusion: We found no evidence for a common altered PBMC expression pattern linked to HAE symptoms in the three families analyzed. All the data considered, differential gene expression in PBMCs do not seem to play a significant role in the predisposition or protection against HAE in the basal -between crises- conditions analyzed. Although the RNA expression pattern associated to the response to viral infections observed in the DR family supports the idea of infectious diseases as a modifying factor for HAE severity, large-scale studies would be needed to statistically associate such expression pattern to the development ...
Source: Orphanet Journal of Rare Diseases - May 20, 2013 Category: Internal Medicine Authors: Alberto López-LeraFátima Sánchez CaboSofía GarridoAna DopazoMargarita López-Trascasa Source Type: research

Erratum: Transfusion Strategies for Acute Upper Gastrointestinal Bleeding
New England Journal of Medicine, Volume 0, Issue 0, Ahead of Print. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - May 17, 2013 Category: Internal Medicine Tags: article Source Type: research

Patient advocacy and dsm-5
Dan Stein and Katharine Phillips comment on the patient experience that has helped define the psychiatric classification of obsessive-compulsive spectrum disorders (OCD) in DSM-5, and describe the importance of taking patient opinion into account. (Source: BMC Medicine)
Source: BMC Medicine - May 17, 2013 Category: Internal Medicine Authors: Dan SteinKatharine Phillips Source Type: research

Bevacizumab – finding its niche in the treatment of heart failure secondary to liver vascular malformations in hereditary hemorrhagic telangiectasia
ConclusionIn this preliminary study of patients with HHT associated with severe hepatic vascular malformations and high cardiac output, administration of bevacizumab was associated with a decrease in cardiac output and reduced duration and number of episodes of epistaxis. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - May 17, 2013 Category: Internal Medicine Authors: Lawrence H Young, Katharine J Henderson, Robert I White, Guadalupe Garcia‐Tsao Tags: Hepatology Elsewhere Source Type: research

Invariant NKT cell activation induces neutrophil accumulation and hepatitis: Oppositely regulated by IL‐4 and IFN‐γ
Conclusions: Our results propose a model in which activated iNKT cells rapidly release IL‐4, which promotes neutrophil survival and hepatitis but also sequentially produce IFN‐γ, which acts in a negative feedback loop to ameliorate iNKT hepatitis by inducing neutrophil apoptosis. Thus, modification of iNKT production of IL‐4 and IFN‐γ may have the potential to improve the efficacy of α‐Galcer in the treatment of liver disease. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - May 17, 2013 Category: Internal Medicine Authors: Hua Wang, Dechun Feng, Ogyi Park, Shi Yin, Bin Gao Tags: Liver Biology and Pathobiology Source Type: research

Adipose tissue‐derived stem cells as a regenerative therapy for a murine steatohepatitis‐induced cirrhosis model
Conclusion: These results suggest that ADSC therapy is beneficial in cirrhosis as it can repair and restore the function of the impaired liver. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - May 17, 2013 Category: Internal Medicine Authors: Akihiro Seki, Yoshio Sakai, Takuya Komura, Alessandro Nasti, Keiko Yoshida, Mami Higashimoto, Masao Honda, Soichiro Usui, Masayuki Takamura, Toshinari Takamura, Takahiro Ochiya, Kengo Furuichi, Takashi Wada, Shuichi Kaneko Tags: Liver Injury and Regeneration Source Type: research

Therapeutic advantage of anti‐vascular adhesion protein‐1 over anti‐α4 integrin antibody in concanavalin a‐induced hepatitis
Conclusions: Our findings show that VAP‐1 and α4 integrin have opposing effects in the Con A‐induced hepatic injury, which is associated with blocking the recruitment of CD4 lymphocytes and monocytic MDSCs, respectively. Moreover these data provide the rationale for a potential therapeutic approach to target adhesion molecules in autoimmune hepatitis. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - May 17, 2013 Category: Internal Medicine Authors: Woo‐Yong Lee, Marko Salmi, Margaret Kelly, Sirpa Jalkanen, Paul Kubes Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research

Adjuvant gemcitabine therapy improves survival in a locally induced, r0‐resectable model of metastatic intrahepatic cholangiocarcinoma
Conclusion: we have developed a murine model of single, R0‐resectable ICC with favorable characteristics for the study of recurrence patterns and mechanisms of metastasis after resection. This model holds great promise for preclinical evaluation of novel multimodal or adjuvant therapies to prevent recurrence and metastasis after R0‐resection. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - May 17, 2013 Category: Internal Medicine Authors: Engin Gürlevik, Bettina Fleischmann‐Mundt, Nina Armbrecht, Thomas Longerich, Norman Woller, Arnold Kloos, Dirk Hoffmann, Axel Schambach, Thomas C. Wirth, Michael P. Manns, Lars Zender, Stefan Kubicka, Florian Kühnel Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research

A randomized trial comparing monthly ibandronate and weekly alendronate for osteoporosis in patients with primary biliary cirrhosis
Conclusion: Both regimens, weekly alendronate and monthly ibandronate, improve bone mass and are comparable in safety for osteoporosis therapy in patients with PBC, although adherence is higher with the monthly regimen. Further larger studies are needed for assessing fracture prevention. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - May 17, 2013 Category: Internal Medicine Authors: Núria Guañabens, Anna Monegal, Dacia Cerdá, África Muxí, Laia Gifre, Pilar Peris, Albert Parés Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research

Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients
Conclusions:Elderly patients are more likely to have NASH and advanced fibrosis than non‐elderly patients with NAFLD. Liver biopsy may be considered in elderly patients and treatment should be initiated in those with NASH and advanced fibrosis. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - May 17, 2013 Category: Internal Medicine Authors: Mazen Noureddin, Katherine P Yates, Ivana A Vaughn, Brent A. Neuschwander‐Tetri, Arun J. Sanyal, Arthur McCullough, Raphael Merriman, Bilal Hameed, Edward Doo, David E. Kleiner, Cynthia Behling, Rohit Loomba, Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice
Conclusion. TGR5 is crucial for liver protection against BA overload after PH, primarily through the control of bile hydrophobicity and cytokine secretion. In the absence of TGR5, intrahepatic stasis of abnormally hydrophobic bile and excessive inflammation, in association with impaired bile flow adaptation and deficient urinary BA efflux, lead to BA overload‐induced liver injury and delayed regeneration. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - May 17, 2013 Category: Internal Medicine Authors: Noémie Péan, Isabelle Doignon, Isabelle Garcin, Aurore Besnard, Boris Julien, Bingkaï Liu, Sophie Branchereau, Anne Spraul, Catherine Guettier, Lydie Humbert, Kristina Schoonjans, Dominique Rainteau, Thierry Tordjmann Tags: Liver Injury and Regeneration Source Type: research

Effect of type 2 diabetes on risk for hepatocellular carcinoma in chronic hepatitis C
(Source: Hepatology)
Source: Hepatology - May 17, 2013 Category: Internal Medicine Authors: Yasuji Arase, Mariko Kobayashi, Hiromitsu Kumada Tags: Hepatobiliary Malignancies Source Type: research

Primary sclerosing cholangitis, autoimmune hepatitis and overlap in utah children: Epidemiology and natural history
Conclusion:Immune mediated liver diseases are important sources of morbidity in children. Using a population based design, this study quantifies the burden and natural history of immune mediated liver disease in children. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - May 17, 2013 Category: Internal Medicine Authors: Mark Deneau, M. Kyle Jensen, John Holmen, Marc S. Williams, Linda S. Book, Stephen L. Guthery Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research

Heart failure in patients treated with bisphosphonates
ConclusionsBisphosphonate users were at increased risk of heart failure compared to age‐ and gender‐matched control subjects. However, users of alendronate showed a dose‐dependent reduction of this risk, suggesting that alendronate may reduce the risk of heart failure.This article is protected by copyright. All rights reserved. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - May 16, 2013 Category: Internal Medicine Authors: Erik Lerkevang Grove, Bo Abrahamsen, Peter Vestergaard Tags: Original Article Source Type: research

The Role of the NIH in Nurturing Clinician-Scientists
New England Journal of Medicine, Volume 0, Issue 0, Ahead of Print. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - May 16, 2013 Category: Internal Medicine Tags: article Source Type: research

Personalized medicine in psychiatry: problems and promises
The central theme of personalized medicine is the premise that an individual's unique physiologic characteristics play a significant role in both disease vulnerability and in response to specific therapies. The major goals of personalized medicine are therefore to predict an individual's susceptibility to developing an illness, achieve accurate diagnosis, and optimize the most efficient and favorable response to treatment. The goal of achieving personalized medicine in psychiatry is a laudable one, because its attainment should be associated with a marked reduction in morbidity and mortality. In this review, we summarize a...
Source: BMC Medicine - May 16, 2013 Category: Internal Medicine Authors: Uzoezi OzomaroClaes WahlestedtCharles Nemeroff Source Type: research

Brunner's Gland Hyperplasia and Adenoma Associated with Colic in an Aged Arabian Mare
(Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - May 16, 2013 Category: Veterinary Research Authors: A. Kullmann, H.C. Schott, V.L. Cook, R.C. Smedley Tags: Case Report Source Type: research

Prognostic Importance of Myocardial Injury in Critically Ill Dogs with Systemic Inflammation
Conclusions and Clinical ImportanceMarkers of myocardial injury predict short‐term death in dogs with systemic inflammation and cTnI significantly contributes to the APPLE score. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - May 16, 2013 Category: Veterinary Research Authors: R. Langhorn, M.A. Oyama, L.G. King, M.C. Machen, D.J. Trafny, V. Thawley, J.L. Willesen, I. Tarnow, M. Kjelgaard‐Hansen Tags: Original Article Source Type: research

Prognostic Value of 24‐Hour Ambulatory ECG (Holter) Monitoring in Boxer Dogs
Conclusions and Clinical ImportanceHolter monitoring in Boxer dogs provides valuable prognostic information. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - May 16, 2013 Category: Veterinary Research Authors: P.F. Mõtsküla, C. Linney, V. Palermo, D.J. Connolly, A. French, J. Dukes McEwan, V. Luis Fuentes Tags: Original Article Source Type: research

Neuromuscular ultrasound in common entrapment neuropathies
Abstract Neuromuscular ultrasound involves the use of high‐resolution ultrasound to image the peripheral nervous system of patients with suspected neuromuscular diseases. It complements electrodiagnostic studies well by providing anatomic information regarding nerves, muscles, vessels, tendons, ligaments, bones, and other structures that cannot be obtained with nerve conduction studies and electromyography. Neuromuscular ultrasound has been studied closely over the past 10 years and has been used most often in the assessment of entrapment neuropathies. This review focuses on the use of neuromuscular ultrasound in 4 of th...
Source: Muscle and Nerve - May 16, 2013 Category: Internal Medicine Authors: Michael S. Cartwright, Francis O. Walker Tags: AANEM Minimonograph Source Type: research

Neurophysiological techniques to detect early small‐fiber dysfunction in transthyretin amyloid polyneuropathy
Conclusions: Plantar SSR and LEPs have similar diagnostic performance in detecting small‐fiber dysfunction in early TTR‐FAP; we propose that both tests should be used to investigate this population. © 2013 Wiley Periodicals, Inc. (Source: Muscle and Nerve)
Source: Muscle and Nerve - May 16, 2013 Category: Internal Medicine Authors: Isabel Conceição, João Costa, José Castro, Mamede de Carvalho Tags: Research Article Source Type: research

The 6‐minute walk test and other endpoints in Duchenne muscular dystrophy: Longitudinal natural history observations over 48 weeks from a multicenter study
Discussion: Findings confirm the clinical meaningfulness of the 6MWD as the most accepted primary clinical endpoint in ambulatory DMD trials. © 2013 Wiley Periodicals, Inc. (Source: Muscle and Nerve)
Source: Muscle and Nerve - May 16, 2013 Category: Internal Medicine Authors: Craig M McDonald, Erik K Henricson, R Ted Abresch, Julaine Florence, Michelle Eagle, Eduard Gappmaier, Allan M. Glanzman, , Robert Spiegel, Jay Barth, Gary Elfring, Allen Reha, Stuart Peltz Tags: Research Article Source Type: research

SMA VALIANT Trial: A prospective, double‐blind, placebo controlled trial of valproic acid in ambulatory adults with spinal muscular atrophy
Conclusions: VPA did not improve strength or function in SMA adults. The outcomes used are feasible and reliable and can be employed in future trials in SMA adults. © 2013 Wiley Periodicals, Inc. (Source: Muscle and Nerve)
Source: Muscle and Nerve - May 16, 2013 Category: Internal Medicine Authors: John T. Kissel, Bakri Elsheikh, Wendy M. King, Miriam Freimer, Charles B. Scott, Stephen Kolb, Sandra P. Reyna, Thomas O. Crawford, Louise R. Simard, Kristin J. Krosschell, Gyula Acsadi, Mary K. Schroth, Guy D'Anjou, Bernard LaSalle, Thomas W. Prior, Susa Tags: Research Article Source Type: research

The internet user profile of Italian families of patients with rare diseases: a web survey
Conclusion: Italian parents of patients with rare diseases are active Internet users, engaged in information search and in online communities.Physicians, health care facilities and health agencies have a great opportunity to engage in online interactions for empowering families of patients of children affected with rare diseases. (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - May 16, 2013 Category: Internal Medicine Authors: Alberto TozziRita MingarelliEleonora AgricolaMichaela GonfiantiniElisabetta PandolfiEmanuela CarloniFrancesco GesualdoBruno Dallapiccola Source Type: research

Dandy-Walker malformation and Wisconsin syndrome: novel cases add further insight into the genotype-phenotype correlations of 3q23q25 deletions
Conclusions: Our data indicate that the 3q deletion is a rare defect associated with DWM, and suggest that the hemizygosity of ZIC1-ZIC4 genes is neither necessary nor sufficient per se to cause this condition. Furthermore, based on a detailed comparison of clinical features and molecular data from 3q deleted patients, we propose clinical diagnostic criteria and refine the critical region for WS. (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - May 16, 2013 Category: Internal Medicine Authors: Alessandro FerrarisLaura BernardiniVesna Sabolic AvramovskaGinevra ZanniSara LoddoElena Sukarova-AngelovskaValentina ParisiAnna CapalboStefano TuminiLorena TravagliniFrancesca ManciniFilip DumaSabina BarresiAntonio NovelliEugenio MercuriLuigi TaraniEnrico Source Type: research

A combination of mutations in AKR1D1 and SKIV2L in a family with severe infantile liver disease
Infantile cholestatic diseases can be caused by mutations in a number of genes involved in different hepatocyte molecular pathways. Whilst some of the essential pathways have a well understood function, such as bile biosynthesis and transport, the role of the others is not known. Here we report the findings of a clinical, biochemical and molecular study of a family with three patients affected with a severe infantile cholestatic disease. A novel homozygous frameshift germline mutation (c.587delG) in the AKR1D1 gene; which encodes the enzyme Δ 4-3-oxosteroid 5β–reductase that is required for synthesis of primary bile ac...
Source: Orphanet Journal of Rare Diseases - May 16, 2013 Category: Internal Medicine Authors: Neil MorganJane HartleyKenneth SetchellMichael SimpsonRachel BrownLouise TeeSian KirkhamShanaz PashaRichard TrembathEamonn MaherPaul GissenDeirdre Kelly Source Type: research

Men's health: Is your willy working?
(Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - May 16, 2013 Category: Internal Medicine Authors: G. Jackson Tags: Editorial Source Type: research

Is tigecycline drug of choice for cIAI and cSSTI?
Linked Comment: Avkan‐Oguz et al. Int J Clin Pract 2013; 67: 505–11. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - May 16, 2013 Category: Internal Medicine Authors: M. Hosgor‐Limoncu Tags: Editorial Source Type: research

Troponin, D‐dimer and … Copeptin?
Linked Comment: Lagi et al. Int J Clin Pract 2013; 67: 512–5. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - May 16, 2013 Category: Internal Medicine Authors: N. Gall Tags: Editorial Source Type: research

Impact of behaviour and lifestyle on bladder health
Bladder conditions, including UTI, UI, and bladder cancer, are highly prevalent and affect a wide range of populations. There are a variety of modifiable behavioral and lifestyle factors that influence bladder health. Some factors, such as smoking and obesity, increase the risk or severity of bladder conditions, whereas other factors, such as pelvic floor muscle exercise, are protective. Although clinical practice may be assumed to be the most appropriate ground for education on behavioral and lifestyle factors that influence bladder health, it is also crucial to extend these messages into the general population through pu...
Source: International Journal of Clinical Practice - May 16, 2013 Category: Internal Medicine Authors: K. L. Burgio, D. K. Newman, M. T. Rosenberg, C. Sampselle Tags: Perspective Source Type: research

Clinical and microbiological efficacy of tigecycline for complicated skin‐soft‐tissue and intra‐abdominal infections in a Turkish university hospital
Conclusion: As a result, tigecycline can be safely used in the treatment of different infections. Compared with cSSTIs, the treatment response is better and the duration of treatment is shorter in cIAIs. However, MIC value must be determined at any rate if tigecycline is to be used in the treatment of Acinetobacter (MDR Acinetobacter, in particular) infections. Clinical cure and microbiological eradication rate of tigecycline therapy changes according to different clinical diagnosis and microorganism. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - May 16, 2013 Category: Internal Medicine Authors: V. Avkan‐Oguz, N. Yapar, S. Alp‐Cavus, K. Demir Onder, E. Aktas, Z. Gulay, N. Cakır Tags: ORIGINAL PAPER Source Type: research

Copeptin: a blood test marker of syncope
ConclusionCopeptin is an efficient marker of syncope. It is useful for confirming or ruling out a diagnosis of syncope in patients who are unable to provide a definite history or when the event is unwitnessed. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - May 16, 2013 Category: Internal Medicine Authors: A. Lagi, A. Cuomo, F. Veneziani, S. Cencetti Tags: Original Paper Source Type: research