Internal Medicine Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.

Management of suspected Lyme borreliosis: experience from an outpatient parenteral antibiotic therapy service
Conclusions: These results show the complexity of translating well-substantiated regimens from clinical trials to actual clinical practice. OPAT was an effective way of administering parenteral therapy for Lyme disease but should not be undertaken lightly due to the rate of adverse events and low rates of success in certain patient groups seen in this study. In view of this, stricter criteria for inclusion to OPAT in line with published guidance should be applied to minimize patient harm and optimize success.
Source: QJM - January 21, 2013 Category: Internal Medicine Authors: White, B., Seaton, R. A., Evans, T. J. Tags: Original papers Source Type: research

Indications, stains and techniques in chromoendoscopy
Early detection of malignancies within the gastrointestinal tract is essential to improve the prognosis and outcome of affected patients. However, conventional white light endoscopy has a miss rate of up to 25% for gastrointestinal pathology, specifically in the context of small and flat lesions within the colon. Chromoendoscopy and other advanced imaging techniques aim at facilitating the visualization and detection of neoplastic lesions and have been applied throughout the gastrointestinal tract. Chromoendoscopy, particularly in combination with magnifying endoscopy has significantly improved means to detect neoplastic l...
Source: QJM - January 21, 2013 Category: Internal Medicine Authors: Trivedi, P. J., Braden, B. Tags: Reviews Source Type: research

A critical overview on ticagrelor in acute coronary syndromes
Until a few years ago, the mainstay of anti-platelet therapy in patients with acute coronary syndrome (ACS) was the combination of aspirin and clopidogrel, a P2Y12 receptor inhibitor. However, current clinical practice has now changed with the introduction of ticagrelor, a more potent cardiovascular drug than clopidogrel, without the limitations related to clopidogrel therapy. In this review, we provide a critical overview of ticagrelor in ACS, highlight the results with ticagrelor in several subgroups of patients and discuss the future trials.
Source: QJM - January 21, 2013 Category: Internal Medicine Authors: Navarese, E. P., Buffon, A., Kozinski, M., Obonska, K., Rychter, M., Kunadian, V., Austin, D., De Servi, S., Sukiennik, A., Kubica, J. Tags: Reviews Source Type: research

Elements: in this month's issue
Source: QJM - January 21, 2013 Category: Internal Medicine Authors: Donnelly, S. C. Tags: Elements: in this month ' s issue Source Type: research

Dewey K. Ziegler, MD (1920-2012)
Dewey K. Ziegler led the Section of Neurology at the University of Kansas from 1966 until it became the Department of Neurology in 1974, when he became the founding Chairman, serving until 1985. He became Professor Emeritus in 1990. He was among the neurologists who established the field as an independent field, rather than a subsidiary of either internal medicine or psychiatry. Indeed, he and his generation of neurologists who trained in New York and Boston then spanned across the nation to create departments of neurology from coast to coast. He was one of the first specialists in headache neurology and was an inspiration...
Source: Neurology - January 21, 2013 Category: Neurology Authors: Barohn, R. J., Rowland, L. P. Tags: IN MEMORIAM Source Type: research

Shortening the ‘short‐course’ therapy: insights into host immunity may contribute to new treatment strategies for tuberculosis
Abstract Achieving global control of tuberculosis (TB) is a great challenge considering the current increases in multi‐drug resistance and mortality rate. Considerable efforts are therefore being made to develop new effective vaccines, more effective and rapid diagnostic tools as well as new drugs. Shortening the duration of TB treatment with revised regimens and modes of delivery of existing drugs, as well as development of new antimicrobial agents and optimization of the host response with adjuvant immunotherapy could have a profound impact on TB cure rates. Recent data show that chronic worm infection and deficiencies...
Source: Journal of Internal Medicine - January 20, 2013 Category: Internal Medicine Authors: T. Schön, M. Lerm, O. Stendahl Tags: Review Source Type: research

Sitagliptin improves beta‐cell function in patients with acute coronary syndromes and newly diagnosed glucose abnormalities: the BEGAMI study
ConclusionSitagliptin improved beta‐cell function and glucose perturbations in patients with ACS and newly diagnosed glucose disturbances.© 2013 The Association for the Publication of the Journal of Internal Medicine
Source: Journal of Internal Medicine - January 19, 2013 Category: Internal Medicine Authors: Camilla Hage, Kerstin Brismar, Suad Efendic, Pia Lundman, Lars Rydén, Linda Mellbin Tags: Original Article Source Type: research

Toxic neurofilamentous axonopathies: Accumulation of neurofilaments and axonal degeneration
Abstract A number of neurotoxic chemicals induce accumulation of neurofilaments in axonal swellings that appear at varying distances from the cell body. This pathology is associated with axonal degeneration of different degrees. The clinical manifestation is most commonly that of a mixed motor–sensory peripheral axonopathy with a disto‐proximal pattern of progression, as in cases of chronic exposure to n‐hexane and carbon disulfide. It has been demonstrated that protein adduct formation is a primary molecular mechanism of toxicity in these axonopathies, but how this mechanism leads to neurofilament accumulation and a...
Source: Journal of Internal Medicine - January 19, 2013 Category: Internal Medicine Authors: Jordi Llorens Tags: Review‐Symposium Source Type: research

Regenerative medicine for the treatment of heart disease
Abstract Heart failure is a major cause of mortality worldwide with a steady increase in prevalence. There is currently no available cure beyond orthotopic heart transplantation, which for a number of reasons is an option only for a small fraction of all patients. Considerable hope has therefore been placed on the possibility of treating a failing heart by replacing lost cardiomyocytes, either through transplantation of various types of stem cells or by boosting endogenous regenerative mechanisms in the heart. Here, we review the current status of stem and progenitor cell‐based therapies for heart disease. We discuss the...
Source: Journal of Internal Medicine - January 19, 2013 Category: Internal Medicine Authors: Emil M. Hansson, Urban Lendahl Tags: Review Source Type: research

Postural orthostatic tachycardia syndrome as a clinically important subgroup of chronic fatigue syndrome: further evidence for central nervous system dysfunctioning
Abstract In this issue of the Journal of Internal Medicine, Lewis and colleagues [1] provide compelling data for a novel subgroup within the chronic fatigue syndrome (CFS) population. They show that approximately 13% (24/179) of CFS patients have postural orthostatic tachycardia syndrome (POTS), a form of dysautonomia implying that when patients change their body position from supine to upright, their heart rate will increase abnormally (tachycardia). POTS is associated with several symptoms often seen in CFS patients: fatigue, lightheadedness, dizziness, neurocognitive deficits and exercise intolerance. Importantly, this ...
Source: Journal of Internal Medicine - January 19, 2013 Category: Internal Medicine Authors: Jo Nijs, Kelly Ickmans Tags: Editorial Comment Source Type: research

Identifying Cardiovascular Disease Risk and Outcome: Use of the Plasma Triglyceride/High‐Density Lipoprotein Cholesterol Concentration Ratio versus Metabolic Syndrome Criteria
ConclusionsAn elevated TG/HDL‐C ratio appears to be just as effective as the MetS diagnosis in predicting the development of CVD.© 2013 The Association for the Publication of the Journal of Internal Medicine
Source: Journal of Internal Medicine - January 19, 2013 Category: Internal Medicine Authors: Martin R. Salazar, Horacio A. Carbajal, Walter G. Espeche, Marcelo Aizpurúa, Carlos E. Leiva Sisnieguez, Carlos E. March, Eduardo Balbín, Rodolfo N. Stavile, Gerald M. Reaven Tags: Original Source Type: research

Opioid use for non‐cancer pain and risk of myocardial infarction among adults
ConclusionsCurrent use of any opioids and cumulative use of 11 or more prescriptions are associated with a small increased risk for MI compared to non‐use and the risk was greater in morphine, meperidine and polytherapy users. Residual confounding, particularly confounding by indication, should be considered in interpreting our results.© 2013 The Association for the Publication of the Journal of Internal Medicine
Source: Journal of Internal Medicine - January 19, 2013 Category: Internal Medicine Authors: Lin Li, Soko Setoguchi, Howard Cabral, Susan Jick Tags: Original Article Source Type: research

Symposium: Vascular Biology, Metabolism and Cancer
Source: Journal of Internal Medicine - January 19, 2013 Category: Internal Medicine Tags: Symposium Source Type: research

Increased susceptibility of natural killer T‐cell‐deficient mice to acetaminophen‐induced liver injury
Conclusion: Our data revealed a novel role of NKT cells in regulating responses to starvation‐induced metabolic stress. Elevated ketone body production in NKT cell‐deficient mice resulted in increased CYP2E1‐mediated APAP biotransformation and susceptibility to AILI. (HEPATOLOGY 2012)
Source: Hepatology - January 18, 2013 Category: Internal Medicine Authors: Brittany V. Martin‐Murphy, Douglas J. Kominsky, David J. Orlicky, Terrence M. Donohue, Cynthia Ju Tags: Liver Injury/Regeneration Source Type: research

Macrophage migration inhibitory factor contributes to ethanol‐induced liver injury by mediating cell injury, steatohepatitis, and steatosis
Conclusion: Taken together, these data indicate that MIF is an important mediator in the regulation of chemokine production and immune cell infiltration in the liver during ethanol feeding and promotes ethanol‐induced steatosis and hepatocyte damage. (HEPATOLOGY 2013)
Source: Hepatology - January 18, 2013 Category: Internal Medicine Authors: Mark A. Barnes, Megan R. McMullen, Sanjoy Roychowdhury, Sorana G. Pisano, Xiuli Liu, Abram B. Stavitsky, Laura E. Nagy Tags: Liver Injury/Regeneration Source Type: research

Hemorrhagic events in hepatocellular carcinoma patients treated with antiangiogenic therapies
Conclusion: This analysis of both randomized and nonrandomized studies evaluating an antiangiogenic agent in HCC showed that whereas the use of sorafenib was associated with an increased risk of bleeding in HCC, this was primarily for lower‐grade events and similar in magnitude to the risk encountered in RCC. (HEPATOLOGY 2012)
Source: Hepatology - January 18, 2013 Category: Internal Medicine Authors: Austin Duffy, Julia Wilkerson, Tim F. Greten Tags: Hepatobiliary Malignancies Source Type: research

Hepatic fat loss in advanced nonalcoholic steatohepatitis: Are alterations in serum adiponectin the cause?
Conclusion: Serum adiponectin levels in advanced NASH are independently associated with hepatic fat loss. Adiponectin may in part be responsible for the paradox of burnt‐out NASH. (HEPATOLOGY 2012)
Source: Hepatology - January 18, 2013 Category: Internal Medicine Authors: David van der Poorten, Caroline F. Samer, Mehdi Ramezani‐Moghadam, Sally Coulter, Marina Kacevska, Dennis Schrijnders, Lindsay E. Wu, Duncan McLeod, Elisabetta Bugianesi, Mina Komuta, Tania Roskams, Christopher Liddle, Lionel Hebbard, Jacob George Tags: Steatohepatitis/Metabolic Liver Disease Source Type: research

Single determination of C‐reactive protein at the time of diagnosis predicts long‐term outcome of patients with hepatocellular carcinoma
Conclusion: Elevated CRP is associated with a dismal prognosis in HCC patients and may become a useful marker for patient selection in HCC management. (HEPATOLOGY 2012)
Source: Hepatology - January 18, 2013 Category: Internal Medicine Authors: Wolfgang Sieghart, Matthias Pinter, Florian Hucke, Ivo Graziadei, Maximilian Schöniger‐Hekele, Christian Müller, Wolfgang Vogel, Michael Trauner, Markus Peck‐Radosavljevic Tags: Hepatobiliary Malignancies Source Type: research

Neuropeptide PACAP in mouse liver ischemia and reperfusion injury: Immunomodulation by the cAMP‐PKA pathway
Conclusion: Our novel findings document the importance of PACAP‐mediated cAMP‐PKA signaling in hepatic homeostasis and cytoprotection in vivo. Because the enhancement of neural modulation differentially regulates local inflammation and prevents hepatocyte death, these results provide the rationale for novel approaches to manage liver inflammation and IRI in transplant patients. (HEPATOLOGY 2012)
Source: Hepatology - January 18, 2013 Category: Internal Medicine Authors: Haofeng Ji, Yu Zhang, Xiu‐da Shen, Feng Gao, Cynthia Y. Huang, Catalina Abad, Ronald W. Busuttil, James A. Waschek, Jerzy W. Kupiec‐Weglinski Tags: Liver Injury/Regeneration Source Type: research

Monocyte/macrophage‐elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions
Conclusion: These data reveal that human NK cells are regulated by a fine‐tuned collaborative action between different types of immune cells, which may reflect a novel immune‐escape mechanism by which tumors dynamically regulate their functions at distinct tumor microenvironments. (HEPATOLOGY 2012)
Source: Hepatology - January 18, 2013 Category: Internal Medicine Authors: Yan Wu, Dong‐Ming Kuang, Wei‐Dong Pan, Yun‐Le Wan, Xiang‐Ming Lao, Dian Wang, Xue‐Feng Li, Limin Zheng Tags: Hepatobiliary Malignancies Source Type: research

CD81/CD9 tetraspanins aid plasmacytoid dendritic cells in recognition of hepatitis C virus–infected cells and induction of interferon‐alpha
Conclusion: Our novel data show that recognition of HCV‐infected hepatoma cells by pDCs involves CD81‐ and CD9‐associated membrane microdomains and induces potent IFN‐α production. (HEPATOLOGY 2012)
Source: Hepatology - January 18, 2013 Category: Internal Medicine Authors: Shuye Zhang, Karen Kodys, Gregory J. Babcock, Gyongyi Szabo Tags: Viral Hepatitis Source Type: research

Leucine‐rich repeat‐containing G protein‐coupled receptor 5 expression in ductular reactions after chemotherapy for metastatic colorectal cancer
Conclusion: These findings suggest that LGR5 may be involved in maintaining DR in damaged liver.
Source: Hepatology Research - January 18, 2013 Category: Internal Medicine Authors: Susumu Saigusa, Koji Tanaka, Yuji Toiyama, Kohei Matsushita, Mikio Kawamura, Yoshinaga Okugawa, Keiichi Uchida, Yasuhiro Inoue, Yasuhiko Mohri, Masato Kusunoki Tags: Short Communication Source Type: research

Prophylaxis for recurrent hepatitis B virus infection following liver transplantation
Source: Hepatology Research - January 18, 2013 Category: Internal Medicine Authors: Takuya Genda Tags: Editorial Source Type: research

A multicenter survey of re‐treatment with pegylated interferon plus ribavirin combination therapy for patients with chronic hepatitis C in Japan
Conclusion: Relapse after previous treatment and a low baseline HCV RNA level have predictive values for a favorable response of PEG IFN plus ribavirin re‐treatment for HCV genotype 1 patients. Re‐treatment for 72 weeks may lead to clinical improvement for genotype 1 patients with complete early virological response and without rapid virological response on re‐treatment.
Source: Hepatology Research - January 18, 2013 Category: Internal Medicine Authors: Tsugiko Oze, Naoki Hiramatsu, Eiji Mita, Norio Akuta, Naoya Sakamoto, Hiroaki Nagano, Yoshito Itoh, Shuichi Kaneko, Namiki Izumi, Hideyuki Nomura, Norio Hayashi, Tetsuo Takehara Tags: Special Report Source Type: research

Guidelines for the Management of Hepatitis C Virus Infection
Source: Hepatology Research - January 18, 2013 Category: Internal Medicine Tags: Special Report Source Type: research

Autosomal dominant cerebellar ataxia type III: a review of the phenotypic and genotypic characteristics
Autosomal Dominant Cerebellar Ataxia (ADCA) Type III is a type of spinocerebellar ataxia (SCA) classically characterized by pure cerebellar ataxia and occasionally, by non-cerebellar signs such as pyramidal signs, ophthalmoplegia, and tremor. The onset of symptoms typically occurs in adulthood; however, a minority of patients develop clinical features in adolescence. The incidence of ADCA Type III is unknown. ADCA Type III consists of six subtypes, SCA5, SCA6, SCA11, SCA26, SCA30, and SCA31. The subtype SCA6 is the most common. These subtypes are associated with four causative genes and two loci. The severity of symptoms a...
Source: Orphanet Journal of Rare Diseases - January 18, 2013 Category: Internal Medicine Authors: Shinsuke FujiokaChristina SundalZbigniew Wszolek Source Type: research

The young osteoarthritic knee: dilemmas in management
The prevalence of osteoarthritis (OA) in the knees is increasing in younger patients due to modern lifestyles; Paul Sutton and Edward Holloway discuss the considerations orthopedic surgeons should take into account when treating this specific age group.
Source: BMC Medicine - January 18, 2013 Category: Internal Medicine Authors: Paul SuttonEdward Holloway Source Type: research

Health Education Materials for Arab Patients: Content and Design Preferences
Med Princ Pract (DOI:10.1159/000346276)
Source: Medical Principles and Practice : Last 20 articles - January 17, 2013 Category: Internal Medicine Source Type: research

Clinical Errors and Medical Negligence
Med Princ Pract (DOI:10.1159/000346296)
Source: Medical Principles and Practice : Last 20 articles - January 17, 2013 Category: Internal Medicine Source Type: research

Fecal Microbiota Transplantation — An Old Therapy Comes of Age
New England Journal of Medicine, Volume 0, Issue 0, Ahead of Print.
Source: New England Journal of Medicine - January 17, 2013 Category: Internal Medicine Tags: article Source Type: research

Heart failure and anti tumor necrosis factor-alpha in systemic chronic inflammatory diseases.
Abstract Tumor necrosis factor alpha (TNF-alpha) antagonists have emerged as an effective therapy for patients with diseases as Crohn's disease, rheumatoid arthritis, and other chronic systemic inflammatory diseases. In the last years, there has been a growing interest in the role that inflammatory cytokines, which sustain the pathogenesis of these diseases, plays in regulating cardiac structure and function, particularly in the progression of chronic heart failure. In fact there is an increase of anti-TNF alpha levels in advanced heart failure but the treatment with anti-TNF alpha has been shown to worsen the prog...
Source: European Journal of Internal Medicine - January 17, 2013 Category: Internal Medicine Authors: Sinagra E, Perricone G, Romano C, Cottone M Tags: Eur J Intern Med Source Type: research

[Ten years' German Protection against Infection Act : Evaluation of the implementation of infection control visits in the ambulatory medical setting.]
[Ten years' German Protection against Infection Act : Evaluation of the implementation of infection control visits in the ambulatory medical setting.] Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013 Jan 17; Authors: Heudorf U, Eikmann T, Exner M Abstract In 2001, the German Protection against Infection Act came into force, implementing a variety of new regulations. For the first time, obligatory infection control visits of the public health departments in surgical ambulatory practices were implemented, as well as optional infection control visits in all medical, dental and paramedical pr...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - January 17, 2013 Category: Global & Universal Authors: Heudorf U, Eikmann T, Exner M Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research

Genome‐wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
Conclusion: By refining the analysis of a PSC GWAS by parallel assessments in a UC GWAS, we were able to detect two novel risk loci at genome‐wide significance levels. GPR35 shows associations in both UC and PSC, whereas TCF4 represents a PSC risk locus not associated with UC. Both loci may represent previously unexplored aspects of PSC pathogenesis. (HEPATOLOGY 2012)
Source: Hepatology - January 17, 2013 Category: Internal Medicine Authors: David Ellinghaus, Trine Folseraas, Kristian Holm, Eva Ellinghaus, Espen Melum, Tobias Balschun, Jon K. Laerdahl, Alexey Shiryaev, Daniel N. Gotthardt, Tobias J. Weismüller, Christoph Schramm, Michael Wittig, Annika Bergquist, Einar Björnsson, Hanns‐Ul Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research

Errata
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Tags: Errata Source Type: research

Reply
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: M. Pasquier Tags: Letter to the Editor Source Type: research

Drug‐related long QT interval in medical inpatients ‐ just the tip of an iceberg
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: J. C. Lee, W. W. B. Chik Tags: Letter to the Editor Source Type: research

Rash in an octogenarian
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: S. Thompson, T. McPherson, J. D. Price, C. Conlon, S. Cooper Tags: Letters to the Editor Source Type: research

Purpura fulminans in a patient with paroxysmal nocturnal haemoglobinuria
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: C. May, K. O'Rourke, K. Jackson, L. Francis, G. A. Kennedy Tags: Letters to the Editor Source Type: research

A rare cause of high anion gap metabolic acidosis
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: S. Milosevic, K. Tran, B. O'Brien Tags: Letters to the Editor Source Type: research

Junior doctor training in pleural procedures: a quality survey
This study was conducted to ascertain the level of junior doctor (physician‐in‐training) training, knowledge and supervision in the management of pleural effusion. The information was collected with the help of a proforma, from 49 junior medical doctors working in a metropolitan health service. All the doctors who participated in the survey had come across pleural effusion in their practice, but only 67% of doctors had any experience with the procedure of diagnostic thoracentesis. Sixty‐seven percent of doctors conveyed that they will refer the majority of cases (75–100%) for radiological‐guided thoracentesis. Th...
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: V. Aiyappan, A. Munawar, F. Thien Tags: Brief Communication Source Type: research

First documented case of imported tick‐borne encephalitis in Australia
This report aims to make physicians from non‐endemic regions aware that tick‐borne encephalitis can be imported and to familiarise them with its clinical course.
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: A. Chaudhuri, D. Růžek Tags: Brief Communications Source Type: research

Selective use of the insulin tolerance test to diagnose hypopituitarism
Abstract The insulin tolerance test is considered the gold standard for assessing the hypothalamic‐pituitary‐adrenal and growth hormone (GH) axes, but its use varies considerably among different endocrine units. We recommend using the insulin tolerance test to assess the hypothalamic‐pituitary‐adrenal axis within 3 months of pituitary surgery, where adrenocorticotropic hormone 1–24 testing is equivocal, and to assess for GH deficiency where the patient is being considered for GH replacement therapy. We also discuss safety issues, how to ensure adequate hypoglycaemia and possible alternative tests, such as the ove...
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: S. Sarlos, W. J. Inder Tags: How I Treat Source Type: research

Survey of practices and policies relating to the use of complementary and alternative medicines and therapies in New South Wales cancer services
ConclusionMost cancer services in NSW recognise potential CAM use by patients and expect medical staff to ask patients about their use of CAM. While few cancer services provided or prescribed CAM, over half permitted inpatients to bring their own CAM into hospital. There was little control over the use of CAM, however, and monitoring was lax. Given the wide usage of CAM by patients with cancer, this lack of control may compromise clinical outcomes, with potentially dangerous consequences.
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: V. M. Raszeja, C. F. C. Jordens, I. H. Kerridge Tags: Ethics in Medicine Source Type: research

Clinical model for ethical cardiopulmonary resuscitation decision‐making
ConclusionsApplying ethical principles commonly used in medicine, a model for ethical CPR decision‐making has been developed that identifies four patient groups, each with a different discussion aim. This approach simplifies the complexities of the CPR decision, providing a structured way to teach CPR decision‐making to doctors and thereby achieve greater consistency in the decisions made.
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: B. Hayes Tags: Original Article Source Type: research

Aprepitant plus palonosetron and dexamethasone for prevention of chemotherapy‐induced nausea and vomiting in patients receiving multiple‐day cisplatin chemotherapy
ConclusionThis study shows aprepitant in combination with palonosetron and dex‐amethasone is safe and effectively controls chemotherapy‐induced nausea and vomiting in patients undergoing 3‐day cisplatin‐based chemotherapy, moreover, the efficacy is maintained during multiple cycles.
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: H. F. Gao, Y. Liang, N. N. Zhou, D. S. Zhang, H. Y. Wu Tags: Original Article Source Type: research

How many life years are lost in patients with rheumatoid arthritis? Secular cause‐specific and all‐cause mortality in rheumatoid arthritis, and their predictors in a long‐term Australian cohort study
ConclusionsWithin a period of 14 years, median life expectancy of patients with RA with disease onset in the early 1990s is reduced by 6–7 years. However, our results also suggest a secular reduction in excess mortality.
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: M. N. Lassere, J. Rappo, I. J. Portek, A. Sturgess, J. P. Edmonds Tags: Original Article Source Type: research

Comparison of plain vertebral X‐ray and dual‐energy X‐ray absorptiometry for the identification of older women for fracture prevention in primary care
ConclusionsThe use of either DXA or X‐ray will identify approximately two‐thirds of women aged 70 years and over who would be eligible for fracture prevention. The use of X‐ray would identify a marginally larger number of women and at lower financial cost but involve substantially greater radiation exposure.
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: P. J. Robinson, R. J. Bell, A. Lanzafame, L. Segal, C. Kirby, L. Piterman, S. R. Davis Tags: Original Article Source Type: research

Screening and treating pulmonary arterial hypertension in a tertiary hospital‐based multidisciplinary clinic: the first 200 patients
ConclusionA multidisciplinary clinic can provide efficient diagnosis and rapid triage to PAH‐specific therapy, if appropriate. Retention rates remain high, at follow up.
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: A. J. Low, D. Fowler, M. K. Manghani, I. Young, R. Garsia, P. Torzillo, P. Youssef, D. S. Celermajer Tags: Original Article Source Type: research

Treatment with unfunded drugs in oncology: the impact of access programmes and clinical trials
ConclusionsPatients' age and gender in older patients impacted on participation in the IAP. Both the IAP and the CO20 trial contributed to a substantial proportion of Australian patients accessing an unfunded treatment, with an estimated 50% of the eligible patient population receiving cetuximab.
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: J. Tie, P. Gibbs Tags: Original Articles Source Type: research

Coronary artery revascularisation: selecting the appropriate strategy
Abstract Advances in interventional cardiology, particularly in better efficacy and safety of drug‐eluting stents, have made percutaneous coronary revascularisation practical for most patients requiring revascularisation. While this has reduced the perceived need for coronary bypass surgery, it has also focused attention on the appropriate use of coronary stents and the complexity of choosing the right revascularisation strategy. To achieve the best outcomes, it would seem that collaboration rather than competition between cardiac surgeons and interventional cardiologists is necessary.
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: M. R. Adams Tags: Clinical Perspectives Source Type: research