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Clot Remover Proves Mettle in Ischemic Stroke (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NEW ORLEANS (MedPage Today) -- A newer cerebral revascularization device not yet approved in the U.S. outperformed the FDA-approved Merci retriever, a randomized trial showed. (Source: MedPage Today Meeting Coverage)
Source: MedPage Today Meeting Coverage - February 5, 2012 Category: Journals (General) Source Type: news

Stereotactic Surgery Plus tPA Shrinks Clots in Stroke (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NEW ORLEANS (MedPage Today) -- Reducing the size of an intracerebral hemorrhage through a minimally invasive surgical technique and thrombolytic therapy may help improve clinical outcomes, a phase II trial showed. (Source: MedPage Today Meeting Coverage)
Source: MedPage Today Meeting Coverage - February 5, 2012 Category: Journals (General) Source Type: news

FDA approves extended-release tablets for type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
FDA approved sitagliptin and metformin hydrochloride (HCl) extended-release (Janumet XR, Merck) tablets, a new treatment for type 2 diabetes that combines sitagliptin, which is the active component of Januvia (sitagliptin), with extended-release metformin. (Source: Modern Medicine)
Source: Modern Medicine - February 5, 2012 Category: Journals (General) Source Type: news

Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase a oncogeneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PTPRD has a tumor suppressor function in neuroblastoma through AURKA dephosphorylation and destabilization and a downstream destabilization of MYCN protein, representing a novel mechanism for the function of PTPRD in neuroblastoma. (Source: BioMed Central)
Source: BioMed Central - February 5, 2012 Category: Journals (General) Authors: Maria MeehanLaavanya ParthasarathiNiamh MoranCaroline A JefferiesNiamh FoleyElisa LazzariDerek MurphyJacqueline RyanBerenice OrtizArmida W M FabiusTimothy A ChanRaymond L Stallings Source Type: research

Heritable genome-wide variation of gene expression and promoter methylation between wild and domesticated chickensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results show that epigenetic variation is inherited in chickens, and we suggest that selection of favourable epigenomes, either by selection of genotypes affecting epigenetic states, or by selection of methylation states which are inherited independently of sequence differences, may have been an important aspect of chicken domestication. (Source: BioMed Central)
Source: BioMed Central - February 4, 2012 Category: Journals (General) Authors: Daniel NattCarl-Johan RubinDominic WrightMartin JohnssonJohan BeltekyLeif AnderssonPer Jensen Source Type: research

MS/MS library facilitated MRM quantification of native peptides prepared by denaturing ultrafiltrationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Naturally occurring native peptides provide important information about physiological states of an organism and its changes in disease conditions but protocols and methods for assessing their abundance are not well-developed. In this paper, we describe a simple procedure for the quantification of non-tryptic peptides in body fluids. The workflow includes an enrichment step followed by two-dimensional fractionation of native peptides and MS/MS data management facilitating the design and validation of LC- MRM MS assays. The added value of the workflow is demonstrated in the development of a triplex LC-MRM MS assay used for q...
Source: BioMed Central - February 4, 2012 Category: Journals (General) Authors: Juraj LencoRenny LanNathan EdwardsRadoslav Goldman Source Type: research

Chronic pneumonia in calves after experimental infection with Mycoplasma bovis strain 1067: Characterization of lung pathology, persistence of variable surface protein antigens and local immune responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results from this study show that infection of calves with M. bovis results in various lung lesions including caseonecrotic pneumonia originating from bronchioli and bronchi. There is long-term persistence of M. bovis as demonstrated by bacteriology and immunohistochemistry for M. bovis antigens, i.e. Vsp antigens and pMB67. The persistence of the pathogen and its ability to evade the specific immune response may in part result from local downregulation of antigen presenting mechanisms and an ineffective humoral immune response with prevalence of IgG1 antibodies that, compared to IgG2 antibodies, are poor ...
Source: BioMed Central - February 4, 2012 Category: Journals (General) Authors: Kathrin HermeyerInka BuchenauAnne ThomasmeyerBerit BaumJoachim SpergserRenate RosengartenMarion Hewicker-Trautwein Source Type: research

Poor food and nutrient intake among Indigenous and non-Indigenous rural Australian childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The nutrient intake and excessive EDNP food consumption levels of Australian rural children from disadvantaged areas are cause for concern regarding their future health and wellbeing, particularly for Indigenous boys. Targeted intervention strategies should address the high consumption of these foods. (Source: BioMed Central)
Source: BioMed Central - February 4, 2012 Category: Journals (General) Authors: Josephine D GwynnVictoria M FloodCatherine A D'EsteJohn R AttiaNicole TurnerJanine CochraneJimmy Chun-Yu LouieJohn H Wiggers Source Type: research

Identification of Avian Wax SynthasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We provide direct evidence that avian preen glands possess both monofunctional and bifunctional WS proteins which have different expression patterns and WS activities with different substrate specificities. (Source: BioMed Central)
Source: BioMed Central - February 4, 2012 Category: Journals (General) Authors: Eva-Maria BiesterJanine HellenbrandJens GruberMats HambergMargrit Frentzen Source Type: research

Clinical experience with power injectable peripherally inserted central catheters in intensive care patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Power injectable peripherally inserted central catheters can be used successfully in most intensive care unit patients with few contraindications and low rates of complications, similar to central venous catheters (CVC). (Source: BioMed Central)
Source: BioMed Central - February 4, 2012 Category: Journals (General) Authors: Mauro PittirutiAlberto BruttiDavide CelentanoMassimiliano PomponiDaniele G BiasucciMaria G AnnettaGiancarlo Scoppettuolo Source Type: research

Cytoplasmic p21 induced by p65 prevents Doxorubicin-induced cell death in Pancreatic Carcinoma cell lineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data suggested p65 could increase p53-mediated cell death in response to DOX in PANC1 cells. Thus, it is worth noting that in p53 null or defective tumors, targeting in down-regulation of p65 may well be useful, leading to the potentiality of chemotherapeutic drugs. (Source: BioMed Central)
Source: BioMed Central - February 4, 2012 Category: Journals (General) Authors: YingQi ZhouGang LiYuan JiChen LiuJingping ZhuYanjun Lu Source Type: research

[Case Report] A lethal injection?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In October, 2010, a 29-year-old man initially presented to a primary care clinic with fevers, sore throat, and odynophagia, and was treated with oral phenoxymethylpenicillin 250 mg four times daily for tonsillitis. He re-presented 72 h later with persisting symptoms and fever of 38·4°C, and was administered 1 000 000 units of intramuscular procaine benzylpenicillin. 4–5 min later, he collapsed with no cardiac output, and cardiopulmonary resuscitation was commenced. Paramedic staff arrived within 20 min and monitoring showed ventricular fibrillation. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Deepak Arumugam, John J Atherton, Paul T Martin Tags: Case Report Source Type: research

[Seminar] Non-specific low back painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Non-specific low back pain has become a major public health problem worldwide. The lifetime prevalence of low back pain is reported to be as high as 84%, and the prevalence of chronic low back pain is about 23%, with 11–12% of the population being disabled by low back pain. Mechanical factors, such as lifting and carrying, probably do not have a major pathogenic role, but genetic constitution is important. History taking and clinical examination are included in most diagnostic guidelines, but the use of clinical imaging for diagnosis should be restricted. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Federico Balagué, Anne F Mannion, Ferran Pellisé, Christine Cedraschi Tags: Seminar Source Type: research

[Seminar] Hereditary angio-oedemaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hereditary angio-oedema is caused by a heterozygous deficiency of C1 inhibitor. This inhibitor regulates several inflammatory pathways, and patients with hereditary angio-oedema have intermittent cutaneous or mucosal swellings because of a failure to control local production of bradykinin. Swellings typically evolve in several hours and persist for a few days. In addition to orofacial angio-oedema, painless swellings affect peripheries, which causes disfigurement or interference with work and other activities of daily living. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Hilary Longhurst, Marco Cicardi Tags: Seminar Source Type: research

[Seminar] Lyme borreliosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lyme borreliosis (Lyme disease) is caused by spirochaetes of the Borrelia burgdorferi sensu lato species complex, which are transmitted by ticks. The most common clinical manifestation is erythema migrans, which eventually resolves, even without antibiotic treatment. However, the infecting pathogen can spread to other tissues and organs, causing more severe manifestations that can involve a patient's skin, nervous system, joints, or heart. The incidence of this disease is increasing in many countries. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Gerold Stanek, Gary P Wormser, Jeremy Gray, Franc Strle Tags: Seminar Source Type: research

[Articles] Cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary heart disease (CE-MARC): a prospective trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CE-MARC is the largest, prospective, real world evaluation of CMR and has established CMR's high diagnostic accuracy in coronary heart disease and CMR's superiority over SPECT. It should be adopted more widely than at present for the investigation of coronary heart disease. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: John P Greenwood, Neil Maredia, John F Younger, Julia M Brown, Jane Nixon, Colin C Everett, Petra Bijsterveld, John P Ridgway, Aleksandra Radjenovic, Catherine J Dickinson, Stephen G Ball, Sven Plein Tags: Articles Source Type: research

[Articles] Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intrauterine and neonatal insults have a high risk of causing substantial long-term neurological morbidity. Comparable cohort studies in resource-poor regions should be done to properly assess the burden of these conditions, and long-term outcomes, such as chronic disease, and to inform policy and programme investments. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Michael K Mwaniki, Maurine Atieno, Joy E Lawn, Charles RJC Newton Tags: Articles Source Type: research

[Articles] Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100 000 women in 123 randomised trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
10-year gains from a one-third breast cancer mortality reduction depend on absolute risks without chemotherapy (which, for oestrogen-receptor-positive disease, are the risks remaining with appropriate endocrine therapy). Low absolute risk implies low absolute benefit, but information was lacking about tumour gene expression markers or quantitative immunohistochemistry that might help to predict risk, chemosensitivity, or both. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Early Breast Cancer Trialists' Collaborative Group (EBCTCG) Tags: Articles Source Type: research

[Articles] Global malaria mortality between 1980 and 2010: a systematic analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Our findings show that the malaria mortality burden is larger than previously estimated, especially in adults. There has been a rapid decrease in malaria mortality in Africa because of the scaling up of control activities supported by international donors. Donor support, however, needs to be increased if malaria elimination and eradication and broader health and development goals are to be met. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Christopher JL Murray, Lisa C Rosenfeld, Stephen S Lim, Kathryn G Andrews, Kyle J Foreman, Diana Haring, Nancy Fullman, Mohsen Naghavi, Rafael Lozano, Alan D Lopez Tags: Articles Source Type: research

[Department of Error] Department of ErrorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glazener C, Boachie C, Buckley B, et al. Urinary incontinence in men after formal one-to-one pelvic-floor muscle training following radical prostatectomy or transurethral resection of the prostate (MAPS): two parallel randomised controlled trials. Lancet 2011; 378: 328–37—This Article (July 23) should have contained the following conflicts of interest statement: “BB has received travel expenses from Astellas, Medtronic, and Pfizer. All other authors declare no conflicts of interest”. This correction has been made to the online version as of Feb 3, 2012. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: The Lancet Tags: Department of Error Source Type: research

[Department of Error] Department of ErrorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abraham WT, Adamson PB, Bourge RC, et al. Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial. Lancet 2011; 377: 658–66—In this Article (Feb 19), the first sentence of the fifth paragraph in the Statistical analysis section on page 661 should have started: “Prespecified supplementary analyses were heart-failure-related hospitalisations during the entire randomised follow-up (Andersen-Gill model)…” Additionally, during internal auditing of this study in preparation for data presentation to regulatory authorities, a small number of unreported events were uncovered. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: The Lancet Tags: Department of Error Source Type: research

[Correspondence] McCoy's syndrome: a new medical entityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 40-year-old woman was sent to our service for a bronchoscopy owing to multiple interstitial pulmonary infiltrates. She complained of a dry cough, dyspnoea, and wheezing of 4 months' duration. She also reported bronchospasm episodes in childhood. The patient had already been seen by three different clinicians and brought with her several test results, including a thorax CT. She had been treated with antibiotics, bronchodilators, and steroids, without improvement. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: José Baddini Martinez, Adriana Ignacio de Padua Tags: Correspondence Source Type: research

[Correspondence] The growing threat to medical independence in conflict zonesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Your Editorial “Torture in Syria's hospitals” (Nov 5, p 1606) relays the allegation of Amnesty International's report that patients in state-run hospitals were being targeted and tortured by authorities to “quell dissent”. The undermining of the independence and work of medical personnel has unfortunately been a theme of recent conflicts. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Dev Kevat, Fiona Lander, Bebe Loff Tags: Correspondence Source Type: research

[Correspondence] Editorial code of conductEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
I fully agree with Syed Wamique Yusuf that the governance of journals should be taken seriously. This is one of the functions of the Committee on Publication Ethics ( COPE). Since 2003, COPE has promoted a Code of Conduct among our members (which now number almost 7000 journal editors worldwide). If anybody feels that a member has not followed this code, they can bring a complaint against them which COPE will consider. The code states that journals should “preclude business needs from compromising intellectual standards” and goes on to state that “editors should make decisions on which articles to publish based on qu...
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Elizabeth Wager Tags: Correspondence Source Type: research

[Correspondence] Editorial code of conductEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In his Correspondence (Nov 5, p 1626), Syed Wamique Yusuf reports the fact that, after acceptance and revision of the proofs, one of his case reports was deemed no longer suitable for publication when he did not comply with the obligatory subscription to the journal. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Francois G Brivet Tags: Correspondence Source Type: research

[Correspondence] Call for a World Dengue DayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dengue fever is a mosquito-borne disease caused by dengue viruses—members of the family Flaviviridae. Severe forms of dengue infection can be fatal and are a leading cause of hospital admission in many parts of the world, placing tremendous pressure on medical resources and having a heavy economic and societal effect. There has been a 30-fold increase in the number of dengue cases over the past 50 years. Recent studies estimate 50–100 million infections each year, although, owing to under-reporting, this figure could be even higher. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Sai Kit Lam, Donald Burke, Duane Gubler, Jorge Méndez-Gálvan, Laurent Thomas Tags: Correspondence Source Type: research

[Correspondence] The Integrated Academic Training programme at OxfordEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In 2006, the Integrated Academic Training programme was initiated in the UK as a result of the Walport report on the crisis of decreasing clinical academic numbers. In Oxford, we decided that the most effective way to manage the programme would be to create a dedicated Oxford University Clinical Academic Graduate School ( OUCAGS). We wish to highlight both some advantages of this approach and challenges within the overall programme. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Kenneth A Fleming, Denise Best Tags: Correspondence Source Type: research

[Correspondence] Non-communicable diseases and the food and beverage industryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The International Food & Beverage Alliance (IFBA) includes ten global food and non-alcoholic beverage manufacturers (Coca-Cola Company, Ferrero, General Mills, Grupo Bimbo, Kellogg's, Kraft Foods, Mars, Nestlé, PepsiCo, and Unilever). Although we cannot speak for the entire food and non-alcoholic beverage industry, nor any other industry, our member companies support initiatives to address the global non-communicable disease (NCD) problem and commend the UN for bringing global attention to this issue, particularly in developing countries. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Janet Voûte, Anne Heughan, Jorge Casimiro Tags: Correspondence Source Type: research

[Correspondence] Improving health: can Pakistan prioritise?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pakistan lags far behind in meeting the Millennium Development Goals. Neonatal mortality is responsible for 57% of all deaths in children younger than 5 years in the country, and Pakistan has the highest neonatal mortality rate in the region. The under-5 mortality rate has decreased by 24% since 1990. However, both rates have remained more or less static in the poorest income quintile. With the devolution of the Ministry of Health last year, Pakistan faces the challenge of developing the much needed provincial infrastructure that would integrate the comprehensive efforts of various stakeholders in promoting better health o...
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Sabeena Jalal Tags: Correspondence Source Type: research

[Correspondence] A tale of devolution, abolition, and performanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sania Nishtar and Ahmed Mehboob's discussion of the abolition of the Health Ministry in Pakistan raises the question of whether the health care problems in Pakistan could be solved by such a move. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Sunita Dodani, Rashid A Chotani Tags: Correspondence Source Type: research

[Correspondence] A tale of devolution, abolition, and performanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sania Nishtar and Ahmed Mehboob (Aug 20, p 648) make a convincing case for retaining a federal institution to take care of national responsibilities in health in Pakistan. Despite the technical appeal of alternative options, the most striking feature of this debate is the low level of response from stakeholders to the threatened abolition of the Ministry of Health, compared with the vigorous backlash against the proposed devolution of the Higher Education Commission. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Asmat Ullah Malik, Moazzam Khalil, Anar Ulikpan, Ahsan Maqbool Ahmad Tags: Correspondence Source Type: research

[Correspondence] Treatment of Helicobacter pylori in Latin America – Authors' replyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Claire Slater and Alexander Ford note that all three treatments compared in our trial achieved eradication probabilities similar to those reported from previous community-based programmes of Helicobacter pylori screening and treatment and that the less-expensive concomitant regimen might be preferable to the more effective, but more costly, triple therapy regimen in a low-resource environment. We agree with both of these points and said as much in our report. The purchase price of the three regimens varied widely between the seven study sites, with a range of US$12–120 for 14-day triple therapy, $7–56 for 10-day sequen...
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: E Robert Greenberg, Garnet L Anderson, Douglas R Morgan, Javier Torres, William D Chey, for the SWOG H pylori Eradication Trial investigators Tags: Correspondence Source Type: research

[Correspondence] Treatment of Helicobacter pylori in Latin AmericaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In their multisite study, Robert Greenberg and colleagues attempted to identify a reliably effective treatment for Helicobacter pylori for use in Latin America. Each study site used locally available drugs and the regimens all contained clarithromycin or clarithromycin–metronidazole, despite the unacceptably low success of triple therapies elsewhere and a high expected prevalence of metronidazole resistance. The success of treatments for infectious diseases is mainly related to the absence of antimicrobial resistance and is predictable if one knows the pattern of resistance and the effect of resistance on the regimens te...
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: David Y Graham, Alba A Trespalacios Tags: Correspondence Source Type: research

[Correspondence] Treatment of Helicobacter pylori in Latin AmericaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Robert Greenberg and colleagues found that, in seven Latin American sites, the probability of Helicobacter pylori eradication with triple therapy lasting 14 days (TT-14) was 82·2%, which was 8·6% higher than with concomitant therapy lasting 5 days (CT-5) and 5·6% higher than with sequential therapy (ST). However, these data deserve further analysis. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Luigi Gatta, Nimish Vakil, Dino Vaira Tags: Correspondence Source Type: research

[Correspondence] Treatment of Helicobacter pylori in Latin AmericaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Robert Greenberg and colleagues (Aug 6, p 507) are to be commended for doing a mass screening and treatment trial for Helicobacter pylori in the general population of Latin America. There is evidence to suggest that population screening and treatment can reduce the incidence of gastric cancer and lessen the economic burden from dyspepsia. However, we are not sure that Greenberg and colleagues' conclusion that 14-day triple therapy is preferable to 5-day concomitant therapy in this setting is warranted. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Claire M Slater, Alexander C Ford Tags: Correspondence Source Type: research

[Obituary] Thomas E BryantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Alison Snyder Tags: Obituary Source Type: research

[Perspectives] Charles Dickens, The Lancet, and Oliver TwistEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The place that for many years served London's Middlesex Hospital as its Outpatient Department is not a beautiful building. Yet it's the oldest element of that great London hospital still standing on Cleveland Street, diagonally across from the vast field the institution used to fill, now sadly strewn with dust and broken bricks. This building has recently been the subject of a very public tussle: the owner intent on its replacement by a huge apartment block; locals and others (myself among them) equally determined to preserve it. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Ruth Richardson Tags: Perspectives Source Type: research

[Perspectives] Joseph Lau: mastering the meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Tony Kirby Tags: Perspectives Source Type: research

[Perspectives] The sound of silenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Desmond O'Neill Tags: Perspectives Source Type: research

[Perspectives] America's plague of incarcerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Arriving at Washington DC's Reagan National airport last year, I, like other visitors, was greeted with large signs featuring the Statue of Liberty and the words: “Welcome to America, home to 5% of the world's people and 25% of the world's prisoners.” The posters were produced by the National Association for the Advancement of Colored People (NAACP) to help publicise their “Misplaced Priority: Over Incarcerate, Under Educate” campaign. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: George J Annas Tags: Perspectives Source Type: research

[World Report] Cuts in Portugal's NHS could compromise careEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Portugal's debt crisis is forcing hospital closures and hasty reform of the National Health Service, causing some observers to raise concerns about patient care. Gonçalo Figueiredo Augusto reports. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Gonçalo Figueiredo Augusto Tags: World Report Source Type: research

[World Report] NICE epilepsy guidance “may be detrimental to patient care”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New NICE guidelines on epilepsies have come under fire by several experts who say that they do not reflect clinical experience and focus too much on drug cost effectiveness. David Holmes reports. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: David Holmes Tags: World Report Source Type: research

[World Report] Regulation failing to keep up with India's trials boomEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ethical violations in clinical trials in India have exposed gaping holes in the country's regulatory system, which has struggled to oversee the booming industry. Amy Yee reports from New Delhi. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Amy Yee Tags: World Report Source Type: research

[Comment] Effects of education on harm-reduction programmesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Harm-reduction programmes are remarkably successful in controlling HIV in injecting drug users worldwide, but more effort is needed to prevent even more HIV infections in this group. Recent reviews individual behavioural approaches, and medical treatment and care. Still, little is known about evidence-based educational intervention effects of harm-reduction programmes for injecting drug users. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Shu-Yu Lyu, Lien-Wen Su, Yi-Ming Arthur Chen Tags: Comment Source Type: research

[Comment] XMRV and CFS—the sad end of a storyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientific papers on chronic fatigue syndrome (CFS) often evoke much debate and emotional reaction, as exemplified by the recent discussions in The Lancet on the PACE trial. Also, the potential role of a retrovirus in CFS kindled a fierce controversy which has recently culminated. In 2009, in Science, Lombardi and colleagues described the occurrence of the xenotropic murine leukaemia virus (MLV)-related virus (XMRV), a gammaretrovirus, in white blood cells in 67% of patients with CFS and in 3·7% of healthy controls. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Frank JM van Kuppeveld, Jos WM van der Meer Tags: Comment Source Type: research

[Comment] Offline: Small acts of kindnessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Seen on a plate somewhere in Italy. Brains. Quite a delicacy. Not a chance. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Richard Horton Tags: Comment Source Type: research

[Comment] Born to be wild?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antisocial behaviour in adolescence can be associated with ill health in the form of self-harm, drug abuse, and mental disorders, and may presage criminal activity later in life. This is a worldwide problem with far-reaching social and economic implications, for individuals as well as for society as a whole. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Thomas Fletcher Tags: Comment Source Type: research

[Comment] What's past is prologue: advances in cardiovascular imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
“The rapid advances in cardiology during the first half of the 20th century may be fairly ascribed to the introduction of new techniques.”Paul Wood, 1951 (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Robert O Bonow Tags: Comment Source Type: research

[Comment] Behavioural problems from perinatal and neonatal insultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The nature, scale, and interactions of behavioural disorders after neonatal and perinatal insults, including preterm birth and infectious diseases, are not well understood. In The Lancet, Michael Mwaniki and colleagues present a broad systematic review of the type and probability of development of a range of neurodevelopmental sequelae, in which they have included 153 research studies and 22 161 liveborn children. The authors report a very high overall prevalence of at least one deficit in any domain (median risk 39·4%, IQR 20·0–54·8%). (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Lucy C Thompson, Christopher Gillberg Tags: Comment Source Type: research

[Comment] The 2011 EBCTCG polychemotherapy overviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study comes 35 years after the first report of the benefit of adjuvant chemotherapy, and is the 16th publication in the group's 28-year history of bringing together individual patient data from all randomised trials worldwide. (Source: LANCET)
Source: LANCET - February 4, 2012 Category: Journals (General) Authors: Carlo Palmieri, Alison Jones Tags: Comment Source Type: research