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FDA: Plavix does not work in 2-14% of patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The FDA has put a new "black box" warning on the anti-clotting drug Plavix, the second best-selling drug in the world.The new label warns that normal doses of Plavix have a potentially deadly lack of effect in 2% to 14% of patients.Such patients are so-called "poor metabolizers" who carry a variant CYP2C19 gene affecting the enzyme that converts Plavix into its active form. The frequency is about 2% of Caucasians, 4% of blacks, and 14% of Chinese.References:New Plavix Warning: Lack of Effect in Many People. WebMD.Image source: A box of Plavix. Wikipedia, Trounce, Creative Commons Attribution-Share Alike 2.5 Generic license...
Source: Clinical Cases and Images - March 20, 2010 Category: Journals (General) Tags: Medications Cardiology Source Type: info

EJPH president's column: in partnership for the public health response to the environmental change * EUPHA office: listen and learn (Objective 1) * Message from the WHO Regional Director for EuropeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Tarkowski, S., Paget, D. Z., Jakab, Z. Tags: European Public Health News Source Type: journals

Johanna Gibson. Intellectual Property, Medicine and Health.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Smith, R. Tags: Book Reviews Source Type: journals

Jan Able Olsen. Principles in health economics and policy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Normand, C. Tags: Book Reviews Source Type: journals

Indices of Multiple Deprivation predict breastfeeding duration in England and WalesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Deprivation, as assessed by the IMD is predictive of breastfeeding duration. Postcode and thus deprivation level can be used as a non-intrusive way to identify women most at risk of low breastfeeding rates. Service provision can be targeted directly at women in areas recognized at being high in deprivation. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Brown, A. E., Raynor, P., Benton, D., Lee, M. D. Tags: Miscellaneous Source Type: journals

Belief in complementary and alternative medicine is related to age and paranormal beliefs in adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Support of CAM was very prevalent in this Flemish adult population. CAM beliefs were strongly associated with paranormal beliefs. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Van den Bulck, J., Custers, K. Tags: Miscellaneous Source Type: journals

The contribution of qualitative research to the development of tailor-made community-based interventions in primary care: a reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Pragmatic trials seem to be oxymoronic. Although the pragmatic trial methodology establishes the effectiveness of interventions under natural, non-experimental conditions, no pragmatic fit is allowed. Qualitative research's contribution to the development of tailor-made community-based interventions lies in providing ongoing evaluations of the dilemmas faced in pragmatic trials and allowing for the development of true tailor-made interventions. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Jansen, Y. J. F. M., Foets, M. M. E., de Bont, A. A. Tags: Miscellaneous Source Type: journals

A cost-utility analysis of adding a bivalent or quadrivalent HPV vaccine to the Irish cervical screening programmeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HPV vaccination has the potential to be very cost effective in Ireland. The quadrivalent vaccine is more cost effective than the bivalent vaccine. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Dee, A., Howell, F. Tags: Sexually transmitted infections Source Type: journals

Increased sexually transmitted infection incidence in a low risk population: Identifying the risk factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Age, condom use and number of sexual partners are important risk factors for STI diagnosis. Contrary to international STI literature, having multiple sexual partners does not increase STI incidence. Age specific behavioural interventions that target increased condom use may be effective in reducing STIs in Ireland. At policy level, a reduction in the taxation on condoms from 13.5 to 5% is needed to lower the prohibitive cost and increase their use. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Shiely, F., Horgan, M., Hayes, K. Tags: Sexually transmitted infections Source Type: journals

HIV transmission risk behaviours among HIV seropositive sexually transmitted infection clinic patients in Cape Town, South AfricaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: People living with HIV/AIDS who contract co-occurring STI are at significant risk for transmitting HIV to uninfected partners. Positive prevention interventions are urgently needed for South Africa. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Kalichman, S. C., Simbayi, L. C., Cain, D. Tags: Sexually transmitted infections Source Type: journals

Organizational capacity for chronic disease prevention: A survey of Canadian public health organizationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data provide an evidence base to identify strengths and gaps in organizational capacity and involvement in chronic disease prevention programming in the organizations that comprise the Canadian public health system. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Hanusaik, N., O'Loughlin, J. L, Kishchuk, N., Paradis, G., Cameron, R. Tags: Policy and planning Source Type: journals

Nursing home policies regarding advance care planning in Flanders, BelgiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: By the end of 2006, almost all NHs in Flanders (Belgium) had an ACP policy. The implementation of ACP policies in Flemish NHs lagged behind other countries, but has developed rapidly since 2000. However, some NHs appear to ban some end-of-life options which are actually legal in Belgium. Further research is needed to investigate whether ACP policies have much impact on the quality of end-of-life care in NHs. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: De Gendt, C., Bilsen, J., Stichele, R. V., Deliens, L. Tags: Policy and planning Source Type: journals

School health promotion: organization of services and roles of health professionals in seven European countriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: All countries had health education and health promotion services but the provision of these services varied considerably from country to country. They were provided either by a specific category of professionals (health personnel or teachers) or considered to be the responsibility of the educational community as a whole. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Pommier, J., Jourdan, D., Berger, D., Vandoorne, C., Piorecka, B., De Carvalho, G. S. Tags: Policy and planning Source Type: journals

Is health recognized in the EU's policy process? An analysis of the European Commission's impact assessmentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results partly support concerns about the potential neglect of health impacts. The results also suggest that health is not considered an important factor when discussing alternative policy choices, and neither does it seem to be an important objective. There is a clear need for further exploration on ways in which health could be more appropriately considered when impacts of other policies are considered by the various DGs. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Stahl, T. P. Tags: Policy and planning Source Type: journals

Intimate partner violence: last year prevalence and association with socio-economic factors among women in Madrid, SpainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Spanish women in our study, experienced past year partner violence at a similar level as in other industrialized countries. Unemployment and low occupational status are associated with physical and psychological-only violence, respectively. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Zorrilla, B., Pires, M., Lasheras, L., Morant, C., Seoane, L., Sanchez, L. M., Galan, I., Aguirre, R., Ramirez, R., Durban, M. Tags: Intimate partner violence Source Type: journals

The hidden figure: sexual intimate partner violence among Pakistani womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: One in five women reported spousal sexual abuse in their married life. Women having more than five children, unwanted pregnancies or reporting differences with in-laws are more likely to be subjected to such abuse. Social support protects women from sexual abuse by intimate partner. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Kapadia, M. Z., Saleem, S., Karim, M. S. Tags: Intimate partner violence Source Type: journals

Influence of cannabis use trajectories, grade repetition and family background on the school-dropout rate at the age of 17 years in FranceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Cannabis use is rarely a trigger for grade repetition but can have either damaging or positive effects on school attainment depending of the level of use. Positive social competence reflected by peer initiation should be investigated to understand this paradoxical effect. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Legleye, S., Obradovic, I., Janssen, E., Spilka, S., Le Nezet, O., Beck, F. Tags: Alcohol, smoking, substance abuse Source Type: journals

Prevalence of tobacco smoking in teachers following anti-smoking policies: results from two French surveys (1999 and 2005)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Anti-smoking policies resulted in a decrease of teachers’ tobacco consumption between 1999 and 2005. However, people with more difficulties in quitting smoking, in particular people with depressive episodes or problems with alcohol, might benefit from comprehensive programmes, including training of health professionals. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Launay, M., Le Faou, A.-L., Sevilla-Dedieu, C., Pitrou, I., Gilbert, F., Kovess-Masfety, V. Tags: Alcohol, smoking, substance abuse Source Type: journals

Reduction of smoking in Dutch adolescents over the past decade and its health gains: a repeated cross-sectional studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study found that, in the past decade, smoking prevalence among adolescents has declined by almost 50%, potentially resulting in a considerable reduction in new cases of COPD or lung cancer. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Gielkens-Sijstermans, C. M., Mommers, M. A., Hoogenveen, R. T., Feenstra, T. L., de Vreede, J., Bovens, F. M., van Schayck, O. C. Tags: Alcohol, smoking, substance abuse Source Type: journals

Correlates of intensive alcohol and drug use in men who have sex with men in Catalonia, SpainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The high percentage of MSM who use alcohol and drugs before and during sex and association between these substances and sexual risk behaviours reveals the need to intensify interventions to reduce their levels of use and/or to reduce the associated damage and risks. These programs must try to cover MSM-specific psychosocial aspects and include prevention for HIV-positive men. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Folch, C., Esteve, A., Zaragoza, K., Munoz, R., Casabona, J. Tags: Alcohol, smoking, substance abuse Source Type: journals

Changes in alcohol consumption and drinking patterns during 11 years of follow-up among ageing men: the FinDrink studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Finnish men born in 1926–1946 do not seem to decrease drinking while ageing. In contrast those born in 1944–1946 increase drinking until their 60’s. This should be taken into consideration in planning health services for aged men in the near future. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Ilomaki, J., Korhonen, M. J., Lavikainen, P., Lipton, R., Enlund, H., Kauhanen, J. Tags: Alcohol, smoking, substance abuse Source Type: journals

Rethinking 'Mental Health Stigma'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: West, K., Hewstone, M., Holmes, E. A. Tags: Viewpoints Source Type: journals

Challenging mental health-related stigma through social contactEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: London, J., Evans-Lacko, S. E. Tags: Viewpoints Source Type: journals

EU cross-border health care and public healthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Muscat, N. A. Tags: Editorials Source Type: journals

From 'Public Health in Europe' to 'European Public Health'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 20, 2010 Category: Journals (General) Authors: Brand, H. Tags: Editorials Source Type: journals

Patches of different types for carotid patch angioplasty.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The number of outcome events is too small to allow reliable conclusions to be drawn and more trial data are required to establish whether any differences do exist. Nevertheless, there is some evidence that other synthetic (e.g. PTFE) patches may be superior to collagen impregnated Dacron grafts in terms of perioperative stroke rates and restenosis. Pseudoaneurysm formation may be more common after use of a vein patch compared with a synthetic patch. PMID: 20238308 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Rerkasem K, Rothwell PM Tags: Cochrane Database Syst Rev Source Type: journals

Anthelmintics for people with neurocysticercosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In patients with viable lesions, evidence from trials of adults suggests albendazole may reduce the number of lesions. In trials of non-viable lesions, seizure recurrence was substantially lower with albendazole, which is counter-intuitive. It may be that steroids influence headache during treatment, but further research is needed to test this. PMID: 20238309 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Abba K, Ramaratnam S, Ranganathan LN Tags: Cochrane Database Syst Rev Source Type: journals

Antibiotic prophylaxis for surgery for proximal femoral and other closed long bone fractures.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Antibiotic prophylaxis should be offered to those undergoing surgery for closed fracture fixation. PMID: 20238310 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Gillespie WJ, Walenkamp GH Tags: Cochrane Database Syst Rev Source Type: journals

Interventions to change the behaviour of health professionals and the organisation of care to promote weight reduction in overweight and obese people.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Most of the included trials had methodological or reporting weaknesses and were heterogeneous in terms of participants, interventions, outcomes, and settings, so we cannot draw any firm conclusions about the effectiveness of the interventions. All of the evaluated interventions would need further investigation before it was possible to recommend them as effective strategies. PMID: 20238311 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Flodgren G, Deane K, Dickinson HO, Kirk S, Alberti H, Beyer FR, Brown JG, Penney TL, Summerbell CD, Eccles MP Tags: Cochrane Database Syst Rev Source Type: journals

Tamoxifen for relapse of ovarian cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We are unable to make any evidence-based recommendations as we found no comparative studies assessing the effectiveness of tamoxifen in women with recurrent ovarian cancer. There is limited evidence on anti-tumour activity from phase 2 studies, but these contain no data on the effect of tamoxifen on symptom control, QOL or the prolongation of life. PMID: 20238312 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Williams C, Simera I, Bryant A Tags: Cochrane Database Syst Rev Source Type: journals

Fibrinolytic agents for peripheral arterial occlusion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: There is some evidence to suggest that intra-arterial rt-PA is more effective than intra-arterial streptokinase or intravenous rt-PA in improving vessel patency in people with peripheral arterial occlusion. There was no evidence that rt-PA was more effective than urokinase for patients with peripheral arterial occlusion and some evidence that initial lysis may be more rapid with rt-PA, depending on the regime. Incidences of haemorrhagic complications were not statistically significantly greater with rt-PA than with other regimes. However, all of the findings come from small studies and a general paucity of res...
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Robertson I, Kessel DO, Berridge DC Tags: Cochrane Database Syst Rev Source Type: journals

Dornase alfa for cystic fibrosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: There is evidence to show that therapy with dornase alfa over a one-month period is associated with an improvement in lung function in CF; results from a trial lasting six months also showed the same effect. Therapy over a two-year period (based on one trial) significantly improved FEV(1) in children and there was a non-significant reduction in the risk of infective exacerbations. Voice alteration and rash appear to be the only adverse events reported with increased frequency in randomised controlled trials. PMID: 20238314 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Jones AP, Wallis C Tags: Cochrane Database Syst Rev Source Type: journals

Intravenous immunoglobulin for suspected or subsequently proven infection in neonates.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Because of concerns about study quality, there is still insufficient evidence to support the routine administration of IVIG to prevent mortality in infants with suspected or subsequently proved neonatal infection. A large study of the effectiveness of IVIG in neonates with suspected infection has recently been completed. Results of the International Neonatal Immunotherapy Study (INIS trial), which enrolled 3,493 infants, are expected to be published in 2010 (http://www.npeu.ox.ac.uk). The results of that trial should establish the usefulness of IVIG for suspected infection in newborns. PMID: 20238315 [PubM...
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Ohlsson A, Lacy J Tags: Cochrane Database Syst Rev Source Type: journals

Cell salvage for minimising perioperative allogeneic blood transfusion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The results suggest cell salvage is efficacious in reducing the need for allogeneic red cell transfusion in adult elective cardiac and orthopaedic surgery. The use of cell salvage did not appear to impact adversely on clinical outcomes. However, the methodological quality of trials was poor. As the trials were unblinded and lacked adequate concealment of treatment allocation, transfusion practices may have been influenced by knowledge of the patients' treatment status potentially biasing the results in favour of cell salvage. PMID: 20238316 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Carless PA, Henry DA, Moxey AJ, O'Connell D, Brown T, Fergusson DA Tags: Cochrane Database Syst Rev Source Type: journals

Corticosteroids for Bell's palsy (idiopathic facial paralysis).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The available evidence from randomised controlled trials shows significant benefit from treating Bell's palsy with corticosteroids. PMID: 20238317 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Salinas RA, Alvarez G, Daly F, Ferreira J Tags: Cochrane Database Syst Rev Source Type: journals

Emergency sclerotherapy versus vasoactive drugs for bleeding oesophageal varices in cirrhotic patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We found no convincing evidence to support the use of emergency sclerotherapy for variceal bleeding in cirrhosis as the first, single treatment when compared with vasoactive drugs. Vasoactive drugs may be safe and effective whenever endoscopic therapy is not promptly available and seems to be associated with less adverse events than emergency sclerotherapy. Other meta-analyses and guidelines advocate that combined vasoactive drugs and endoscopic therapy is superior to either intervention alone. PMID: 20238318 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: D'Amico G, Pagliaro L, Pietrosi G, Tarantino I Tags: Cochrane Database Syst Rev Source Type: journals

Pit and fissure sealants versus fluoride varnishes for preventing dental decay in children and adolescents.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: There was some evidence on the superiority of pit and fissure sealants over fluoride varnish application in the prevention of occlusal decays. However, current scarce data limit recommendations on whether to apply pit and fissure sealants or fluoride varnishes on occlusal surfaces. PMID: 20238319 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Hiiri A, Ahovuo-Saloranta A, Nordblad A, Mäkelä M Tags: Cochrane Database Syst Rev Source Type: journals

Bisphosphonates in multiple myeloma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Adding bisphosphonates to the treatment of MM reduces pathological vertebral fractures, SREs and pain but not mortality. Assuming the baseline risk of 20% to 50% for vertebral fracture without treatment, we estimate that between eight and 20 MM patients should be treated to prevent vertebral fracture(s) in one patient. Assuming the baseline risk of 31% to 76% for pain amelioration without treatment, we estimate that between five to 13 MM patients should be treated to reduce pain in one patient. Also, with the baseline risk of 35% to 86% for SREs without treatment, we estimate that between six and 15 MM patient...
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Mhaskar R, Redzepovic J, Wheatley K, Clark OA, Miladinovic B, Glasmacher A, Kumar A, Djulbegovic B Tags: Cochrane Database Syst Rev Source Type: journals

Medical versus surgical management for gastro-oesophageal reflux disease (GORD) in adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: There is evidence that laparoscopic fundoplication surgery is more effective than medical management for the treatment of GORD at least in the short to medium term. Surgery does carry some risk and whether the benefits of surgery are sustained in the long term remains uncertain. Treatment decisions for GORD should be based on patient and surgeon preference. PMID: 20238321 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Wileman SM, McCann S, Grant AM, Krukowski ZH, Bruce J Tags: Cochrane Database Syst Rev Source Type: journals

Preventive staff-support interventions for health workers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: There is insufficient evidence for the effectiveness of stress management training interventions to reduce job stress and prevent burnout among healthcare workers beyond the intervention period. Low quality evidence suggests that longer-term interventions with refresher or booster sessions may have more sustained positive effect, but this needs to be rigorously evaluated in further trials.Low quality evidence exists to show that management interventions may improve some measures of job satisfaction. However, further trials are needed to assess whether this finding is replicable in other settings. There was ins...
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: van Wyk BE, Pillay-Van Wyk V Tags: Cochrane Database Syst Rev Source Type: journals

Skin patch and vaginal ring versus combined oral contraceptives for contraception.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Effectiveness was similar for the methods compared. The patch could lead to more discontinuation while the vaginal ring showed little difference. The patch group had better compliance than the COC group but more side effects. Ring users generally had fewer adverse events than COC users but more vaginal irritation and discharge. High losses to follow up can affect the validity of the results. PMID: 20238323 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Lopez LM, Grimes DA, Gallo MF, Schulz KF Tags: Cochrane Database Syst Rev Source Type: journals

Group-based parent-training programmes for improving emotional and behavioural adjustment in children from birth to three years old.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The findings of this review provide some support for the use of group-based parenting programmes to improve the emotional and behavioural adjustment of children with a maximum mean age of three years eleven months. There is, insufficient evidence to reach firm conclusions regarding the role that such programmes might play in the primary prevention of such problems. There are also limited data available concerning the long-term effectiveness of these programmes. Further research is needed. PMID: 20238324 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Barlow J, Smailagic N, Ferriter M, Bennett C, Jones H Tags: Cochrane Database Syst Rev Source Type: journals

Washout policies in long-term indwelling urinary catheterisation in adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The data from five trials comparing differing washout policies were sparse and trials were generally of poor quality or poorly reported. The evidence was too scanty to conclude whether or not washouts were beneficial. In the first instance we require further rigorous, high quality trials with adequate power to detect any benefit from washout being performed as opposed to none. Then trials comparing different washout solutions, washout volumes, frequencies/timings and routes of administration are needed. PMID: 20238325 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Hagen S, Sinclair L, Cross S Tags: Cochrane Database Syst Rev Source Type: journals

Lay health workers in primary and community health care for maternal and child health and the management of infectious diseases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: LHWs provide promising benefits in promoting immunisation uptake and breastfeeding, improving TB treatment outcomes, and reducing child morbidity and mortality when compared to usual care. For other health issues, evidence is insufficient to draw conclusions about the effects of LHWs. PMID: 20238326 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Lewin S, Munabi-Babigumira S, Glenton C, Daniels K, Bosch-Capblanch X, van Wyk BE, Odgaard-Jensen J, Johansen M, Aja GN, Zwarenstein M, Scheel IB Tags: Cochrane Database Syst Rev Source Type: journals

Chemotherapy for advanced gastric cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Chemotherapy significantly improves survival in comparison to best supportive care. In addition, combination chemotherapy improves survival compared to single-agent 5-FU. All patients should be tested for their HER-2 status and trastuzumab should be added to a standard fluoropyrimidine/cisplatin regimen in patients with HER-2 positive tumours. Two and three-drug regimens including 5-FU, cisplatin, with or without an anthracycline, as well as irinotecan or docetaxel-containing regimens are reasonable treatment options for HER-2 negative patients. PMID: 20238327 [PubMed - in process] (Source: Cochrane Databa...
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Wagner AD, Unverzagt S, Grothe W, Kleber G, Grothey A, Haerting J, Fleig WE Tags: Cochrane Database Syst Rev Source Type: journals

Non-surgical interventions for eosinophilic esophagitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: As only three relevant RCTs were identified, we have limited capacity to compare the benefits and harms of medical interventions currently used for treating EE. Further RCTs on therapies for EE are required. PMID: 20238328 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Elliott EJ, Thomas D, Markowitz JE Tags: Cochrane Database Syst Rev Source Type: journals

Interventions to prevent hypothermia at birth in preterm and/or low birthweight infants.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Plastic wraps or bags, plastic caps, SSC and transwarmer mattresses all keep preterm infants warmer leading to higher temperatures on admission to neonatal units and less hypothermia. However, the small numbers of infants and studies and the absence of long-term follow-up mean that firm recommendations for clinical practice cannot be given. PMID: 20238329 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: McCall EM, Alderdice F, Halliday HL, Jenkins JG, Vohra S Tags: Cochrane Database Syst Rev Source Type: journals

Continuous passive motion following total knee arthroplasty in people with arthritis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The effects of continuous passive motion on knee range of motion are too small to justify its use. There is weak evidence that continuous passive motion reduces the subsequent need for manipulation under anaesthesia. PMID: 20238330 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Harvey LA, Brosseau L, Herbert RD Tags: Cochrane Database Syst Rev Source Type: journals

Interventions to improve adherence to lipid lowering medication.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: At this stage, reminding patients seems the most promising intervention to increase adherence to lipid lowering drugs. The lack of a gold standard method of measuring adherence is one major barrier in adherence research. More reliable data might be achieved by newer methods of measurement, more consistency in adherence assessment and longer duration of follow up. More recent studies have started using more reliable methods for data collection but follow-up periods remain too short. Increased patient-centredness with emphasis on the patient's perspective and shared decision-making might lead to more conclusive ...
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Schedlbauer A, Davies P, Fahey T Tags: Cochrane Database Syst Rev Source Type: journals

Planned early birth versus expectant management for women with preterm prelabour rupture of membranes prior to 37 weeks' gestation for improving pregnancy outcome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: There is insufficient evidence to guide clinical practice on the benefits and harms of immediate delivery compared with expectant management for women with PPROM. To date all of the clinical trials have had methodological weaknesses and have been underpowered to detect meaningful measures of infant and maternal morbidity. PMID: 20238332 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 20, 2010 Category: Journals (General) Authors: Buchanan SL, Crowther CA, Levett KM, Middleton P, Morris J Tags: Cochrane Database Syst Rev Source Type: journals